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TDMS Study 97013-94 Pathology Tables

NTP Experiment-Test: 97013-94         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03
Route: DOSED WATER                                                                                                Time: 14:40:44

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7789-38-0

       Lock Date:  07/30/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-94         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:40:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 3            4            4            7                                     
    Natural Death                                                   1            2            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 7            5            4            2                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 3 (30%)      4 (40%)      6 (60%)      1 (10%)                               
      Inflammation, Chronic Active                    10 (100%)     6 (60%)      7 (70%)      5 (50%)                               
      Mineralization                                   1 (10%)                                                                      
      Hepatocyte, Fatty Change                                                   1 (10%)                                            
      Hepatocyte, Necrosis                             1 (10%)      1 (10%)                   1 (10%)                               
      Hepatocyte, Vacuolization Cytoplasmic            7 (70%)      4 (40%)      4 (40%)      3 (30%)                               
   Mesentery                                          (2)                                                                           
      Fat, Fibrosis                                    1 (50%)                                                                      
      Fat, Necrosis                                    2 (100%)                                                                     
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Epithelium, Hyperkeratosis                       1 (10%)      2 (20%)      1 (10%)      7 (70%)                               
      Epithelium, Hyperplasia                          5 (50%)      6 (60%)      4 (40%)      8 (80%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                             1 (10%)                   1 (10%)                               
      Mineralization                                   1 (10%)      2 (20%)                                                         
      Subcapsular, Hyperplasia                         5 (50%)      6 (60%)      1 (10%)                                            
   Parathyroid Gland                                                                         (1)                                    
      Necrosis                                                                                1 (100%)                              
   Pituitary Gland                                    (10)         (10)         (9)          (10)                                   
      Pars Distalis, Cyst                              3 (30%)      2 (20%)                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-94         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:40:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hypertrophy                                                 2 (22%)      6 (60%)                               
      Pars Distalis, Mineralization                                                           1 (10%)                               
   Thyroid Gland                                      (10)         (9)          (10)         (10)                                   
      Infiltration Cellular, Lymphocyte                             2 (22%)      7 (70%)      8 (80%)                               
      Follicle, Degeneration                                        1 (11%)                                                         
      Follicle, Depletion Secretory                    1 (10%)      8 (89%)      9 (90%)     10 (100%)                              
      Follicular Cell, Hypertrophy                                  8 (89%)     10 (100%)    10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (9)          (10)         (10)                                   
      Atrophy                                          1 (10%)                   1 (10%)      2 (20%)                               
      Cyst                                             1 (10%)      1 (11%)                                                         
      Inflammation, Chronic Active                     1 (10%)      3 (33%)      1 (10%)                                            
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Inflammation, Suppurative                                     3 (30%)                                                         
      Endometrium, Hyperplasia, Cystic                 8 (80%)      7 (70%)      5 (50%)      2 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (1)          (2)                                                              
      Mediastinal, Hyperplasia, Lymphoid                            1 (50%)                                                         
   Lymph Node, Mandibular                             (9)          (10)         (10)         (9)                                    
      Hyperplasia, Lymphoid                            2 (22%)      4 (40%)      2 (20%)      2 (22%)                               
      Inflammation, Chronic Active                                               1 (10%)                                            
   Lymph Node, Mesenteric                             (9)          (9)          (10)         (10)                                   
      Hyperplasia, Lymphoid                                         1 (11%)                                                         
      Infiltration Cellular, Polymorphonuclear                      1 (11%)                                                         
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                                 1 (10%)                               
      Hematopoietic Cell Proliferation                 3 (30%)      3 (30%)      6 (60%)      4 (40%)                               
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          2 (20%)      5 (50%)      6 (60%)      9 (90%)                               
      Cyst                                                                       1 (10%)      1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-94         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:40:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (6)          (8)          (8)          (4)                                    
      Inflammation, Chronic Active                     1 (17%)      1 (13%)                                                         
      Epidermis, Hyperplasia, Focal                    5 (83%)      3 (38%)      2 (25%)      3 (75%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Alveolar Epithelium, Hyperplasia                                           1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Mineralization                                                             1 (10%)      2 (20%)                               
      Nephropathy                                      6 (60%)      6 (60%)      8 (80%)      8 (80%)                               
      Cortex, Cyst                                                  2 (20%)                                                         
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                                       1 (10%)      2 (20%)      1 (10%)                               
      Renal Tubule, Degeneration                                                              7 (70%)                               
      Renal Tubule, Hypertrophy                                                  2 (20%)      5 (50%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-94         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:40:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            2            4            3                                     
    Natural Death                                      2            1                         3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 6            7            6            4                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 (10%)                   2 (20%)      1 (10%)                               
      Inflammation, Chronic Active                     5 (50%)      5 (50%)      7 (70%)      4 (40%)                               
      Hepatocyte, Fatty Change                         2 (20%)                   1 (10%)                                            
      Hepatocyte, Necrosis                             1 (10%)                                                                      
      Hepatocyte, Vacuolization Cytoplasmic            5 (50%)      6 (60%)      6 (60%)      3 (30%)                               
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Epithelium, Hyperkeratosis                       2 (20%)      2 (20%)      1 (10%)      2 (20%)                               
      Epithelium, Hyperplasia                          4 (40%)      2 (20%)      3 (30%)      5 (50%)                               
      Epithelium, Hyperplasia, Focal                                1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hypertrophy                                      5 (50%)      7 (70%)      6 (60%)      1 (10%)                               
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Cyst                              1 (10%)                                                                      
      Pars Distalis, Hypertrophy                                                              2 (20%)                               
   Thyroid Gland                                      (10)         (10)         (10)         (9)                                    
      Infiltration Cellular, Lymphocyte                                                       4 (44%)                               
      Follicle, Cyst                                                1 (10%)                                                         
      Follicle, Depletion Secretory                    3 (30%)      4 (40%)      4 (40%)      7 (78%)                               
      Follicular Cell, Hypertrophy                                  6 (60%)      8 (80%)      8 (89%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-94         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:40:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
      Cyst                                             1 (10%)                                                                      
      Degeneration                                     1 (10%)      1 (10%)                   7 (70%)                               
      Granuloma Sperm                                                            1 (10%)                                            
      Inflammation, Chronic Active                     1 (10%)                                                                      
   Preputial Gland                                                 (2)          (3)          (1)                                    
      Atrophy                                                       1 (50%)      1 (33%)                                            
      Duct, Ectasia                                                 2 (100%)     2 (67%)      1 (100%)                              
   Testes                                             (10)         (10)         (10)         (10)                                   
      Mineralization                                                1 (10%)                                                         
      Bilateral, Germinal Epithelium, Degeneration                               3 (30%)      8 (80%)                               
      Germinal Epithelium, Degeneration                1 (10%)      1 (10%)      2 (20%)                                            
      Interstitial Cell, Hyperplasia                                                          3 (30%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (9)          (10)         (10)         (7)                                    
      Hyperplasia, Lymphoid                            2 (22%)                   4 (40%)      1 (14%)                               
   Lymph Node, Mesenteric                             (9)          (10)         (10)         (9)                                    
      Hyperplasia, Lymphoid                                                      1 (10%)                                            
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                                 1 (10%)                               
      Hematopoietic Cell Proliferation                              1 (10%)      2 (20%)                                            
   Thymus                                             (10)         (10)         (9)          (9)                                    
      Atrophy                                          5 (50%)      1 (10%)      3 (33%)      6 (67%)                               
      Cyst                                             3 (30%)      1 (10%)                   1 (11%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (9)          (9)          (9)          (8)                                    
      Inflammation, Chronic Active                     1 (11%)      1 (11%)                                                         
      Epidermis, Hyperplasia, Focal                    3 (33%)      4 (44%)      3 (33%)      1 (13%)                               
      Hair Follicle, Sebaceous Gland, Atrophy                       1 (11%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-94         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:40:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                                  1 (10%)      1 (10%)                                            
      Thrombosis                                       1 (10%)                                                                      
      Alveolar Epithelium, Hyperplasia                                                        1 (10%)                               
      Alveolus, Infiltration Cellular, Histiocyte      1 (10%)                                                                      
      Perivascular, Infiltration Cellular,                                                                                          
        Lymphocyte                                     1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Hydronephrosis                                                                          2 (20%)                               
      Inflammation                                                               1 (10%)                                            
      Mineralization                                                                          1 (10%)                               
      Nephropathy                                      7 (70%)      6 (60%)      7 (70%)     10 (100%)                              
      Cortex, Cyst                                     1 (10%)                                1 (10%)                               
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                          2 (20%)                                2 (20%)                               
      Renal Tubule, Degeneration                                                 1 (10%)      8 (80%)                               
      Renal Tubule, Hypertrophy                                                  1 (10%)      6 (60%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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