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TDMS Study 97013-95 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                   WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                            DATE: 10/08/03  
EXPERIMENT: 97013 TEST: 95                                                                                        TIME: 10:13:08    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: 26-39 WEEKS                              ROUTE: DOSED WATER                                            NTP:  C97013J     
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                                                             FINAL/MICE                                                             
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)             DATE: 10/08/03    
EXPERIMENT: 97013 TEST: 95                                                                                        TIME: 10:17:56    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: 26                                       ROUTE: DOSED WATER                                            NTP:  97013J      
CONT: NO1-ES-65406                                                                                                CAS: 75-27-4      
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                                26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                             
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     8.7    22.4       2.4     22.7    0.28       18      1.0     23.2    0.11       15      0.8     22.8    0.09       24       
  2     5.5    23.7       2.9     24.0    0.53       21      2.5     23.3    0.45       37      1.9     20.6    0.35       66       
  3     7.4    25.0       2.9     26.1    0.39       19      2.8     25.0    0.38       39      2.0     23.8    0.27       60       
  4     5.7    25.6       3.3     27.5    0.58       21      2.9     26.5    0.51       38      2.6     25.6    0.46       71       
  5     5.0    27.2       3.1     28.6    0.62       19      2.7     27.6    0.54       35      2.5     26.3    0.50       68       
  6     4.7    27.9       3.1     29.1    0.66       19      2.8     28.5    0.60       34      2.6     27.0    0.55       67       
  7     4.2    28.5       3.2     29.4    0.76       19      2.9     28.7    0.69       36      2.4     27.6    0.57       61       
  8     4.1    28.1       3.6     30.6    0.88       20      3.1     29.5    0.76       37      2.7     27.4    0.66       69       
  9     3.0    28.7       3.9     32.0    1.30       21      3.1     30.8    1.03       35      3.0     28.7    1.00       72       
 10     4.6    29.4       3.4     33.1    0.74       18      3.1     31.8    0.67       34      2.9     29.5    0.63       68       
 11     4.3    30.8       3.6     33.5    0.84       19      3.1     32.5    0.72       34      2.7     30.5    0.63       63       
 12     4.2    31.2       3.4     34.0    0.81       18      3.3     33.0    0.79       35      3.1     31.3    0.74       70       
 13     4.3    31.4       3.4     33.9    0.79       17      3.3     33.1    0.77       35      3.0     30.4    0.70       68       
 14     3.4    31.7       3.8     34.7    1.12       19      3.1     33.1    0.91       33      3.2     30.7    0.94       74       
 15     4.0    31.6       4.2     34.6    1.05       21      3.5     33.6    0.88       37      3.1     31.0    0.78       70       
 16     4.8    32.4       4.0     35.2    0.83       20      3.2     34.3    0.67       33      3.3     31.9    0.69       72       
 17     4.7    32.2       4.2     35.5    0.89       20      3.3     34.5    0.70       33      3.6     32.5    0.77       78       
 18     5.1    32.5       3.8     36.0    0.75       19      3.6     35.2    0.71       35      3.4     32.3    0.67       73       
 19     4.5    33.4       3.3     36.3    0.73       16      3.3     35.6    0.73       32      3.3     33.2    0.73       69       
 20     5.4    34.2       3.5     39.1    0.65       16      3.3     37.0    0.61       31      2.9     34.3    0.54       60       
 21     4.3    35.1       3.5     39.2    0.81       16      3.4     36.8    0.79       32      2.8     33.0    0.65       60       
 22     4.9    35.3       3.8     40.2    0.78       16      3.7     37.5    0.76       34      3.1     35.1    0.63       62       
 23     5.5    36.3       3.8     40.5    0.69       16      3.8     37.2    0.69       35      3.0     35.2    0.55       59       
 24     5.2    36.6       3.7     41.6    0.71       16      3.5     37.9    0.67       32      2.9     36.0    0.56       56       
 25     3.7    36.7       3.5     42.0    0.95       15      3.5     37.0    0.95       33      3.2     36.2    0.86       61       
 26     5.0    36.9       3.8     42.2    0.76       16      3.2     38.6    0.64       29      3.1     36.7    0.62       58       
 27     4.1    36.9       3.6     42.2    0.88       15      3.5     39.4    0.85       31      3.2     35.4    0.78       63       
 28     4.4    37.6       3.8     42.4    0.86       16      3.4     40.2    0.77       30      3.5     35.0    0.80       70       
 29     5.4    37.5       3.7     42.9    0.69       15      3.6     39.8    0.67       31      3.5     35.1    0.65       69       
 30     5.0    37.5       4.1     42.6    0.82       17      4.0     40.2    0.80       35      3.6     36.3    0.72       69       
 31     5.2    37.6       4.0     42.8    0.77       16      3.7     40.6    0.71       32      3.0     36.6    0.58       57       
 32     3.7    37.0       3.9     43.1    1.05       16      3.6     40.4    0.97       31      3.2     37.1    0.86       61       
 33     5.0    38.9       4.0     42.8    0.80       16      3.5     40.0    0.70       30      3.2     37.5    0.64       59       
 34     3.9    37.6       3.6     42.2    0.92       15      3.2     40.5    0.82       28      3.1     37.1    0.79       58       
 35     4.2    37.2       3.9     40.7    0.93       17      3.4     40.3    0.81       29      3.2     36.8    0.76       61       
 36     4.0    35.8       3.9     40.5    0.98       17      3.3     39.5    0.83       29      3.6     37.3    0.90       67       
 37     4.5    37.2       3.8     41.3    0.84       16      3.6     38.8    0.80       32      3.4     37.5    0.76       63       
 38     4.7    38.2       3.9     41.6    0.83       16      3.2     39.1    0.68       28      3.4     37.9    0.72       62       
 39     4.1    38.9       3.8     41.8    0.93       16      3.1     39.3    0.76       27      3.0     38.3    0.73       56       
==================================================================================================================================  
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                                26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                             
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
 40     4.2    39.9       3.8     42.0     0.90      16      3.4     39.1     0.81      30      2.9     38.1     0.69      53       
 41     4.1    41.7       4.0     40.8     0.98      17      3.4     38.5     0.83      31      3.4     37.8     0.83      63       
 42     4.0    42.4       4.1     41.8     1.03      17      3.2     39.1     0.80      29      3.2     38.3     0.80      58       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    5.0    27.7       3.2     29.6     0.71      19      2.8     28.7     0.62      34      2.5     27.0     0.55      64       
SD(D)   1.5               0.4              0.25       1      0.6              0.23       6      0.6              0.23      13       
CV(E)  29.7              11.8             35.7      6.7     21.6             36.7     17.9     24.9             41.6     19.7       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.5    36.4       3.8     40.3     0.86      17      3.4     38.0     0.77      32      3.2     35.5     0.72      64       
SD(D)   0.6               0.2              0.12       2      0.2              0.09       2      0.2              0.11       6       
CV(E)  12.7               5.3             14.0      9.8      6.1             11.8      7.5      6.8             14.6     10.0       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                                26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                             
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1                       2.3     19.1               21      1.4     18.9               26      0.9     19.3               32       
  2     6.6    20.0       3.8     20.6     0.58      32      3.3     20.0     0.50      58      2.6     18.8     0.39      98       
  3     8.9    21.2       4.5     22.2     0.51      35      4.5     21.6     0.51      73      3.6     20.8     0.40     121       
  4     6.0    22.0       4.5     22.9     0.75      34      4.1     22.4     0.68      64      4.3     21.9     0.72     137       
  5     4.5    23.3       4.4     23.7     0.98      33      4.2     23.1     0.93      64      4.0     23.2     0.89     122       
  6                       4.3     24.0               32      4.6     23.8               67      4.7     23.1              142       
  7     6.2    24.2       4.6     23.8     0.74      34      4.5     23.4     0.73      68      4.4     23.3     0.71     132       
  8     6.8    24.8       5.0     25.1     0.74      35      5.0     24.1     0.74      72      5.2     24.5     0.76     149       
  9     5.4    25.2       5.4     25.9     1.00      37      4.0     24.7     0.74      57      5.2     24.8     0.96     147       
 10     5.3    26.4       5.4     26.1     1.02      36      5.0     25.4     0.94      69      5.1     24.8     0.96     143       
 11     6.8    26.9       5.0     27.0     0.74      33      4.8     26.5     0.71      63      6.1     25.8     0.90     166       
 12     6.0    26.7       5.5     26.2     0.92      36      4.6     26.2     0.77      61      5.7     26.5     0.95     152       
 13     5.0    27.3       5.1     26.7     1.02      34      4.1     26.2     0.82      55      5.2     26.8     1.04     136       
 14     4.8    27.8       4.7     27.1     0.98      30      4.4     27.1     0.92      57      5.1     26.7     1.06     134       
 15     5.1    28.1       4.7     27.3     0.92      30      4.9     27.9     0.96      61      5.1     27.4     1.00     130       
 16     4.1    28.9       4.6     27.6     1.12      29      4.3     28.4     1.05      54      4.8     27.6     1.17     122       
 17     5.7    28.5       4.9     27.9     0.86      30      4.8     29.2     0.84      57      4.8     27.4     0.84     123       
 18     5.1    28.2       5.0     28.6     0.98      30      5.0     29.4     0.98      60      5.1     27.8     1.00     128       
 19     4.3    29.3       4.8     29.0     1.12      29      5.1     30.4     1.19      58      4.4     29.2     1.02     105       
 20     4.8    29.9       4.7     29.8     0.98      28      4.1     31.4     0.85      45      4.6     29.6     0.96     109       
 21     5.2    30.3       4.8     29.5     0.92      29      4.9     30.6     0.94      56      4.8     30.5     0.92     111       
 22     5.5    30.2       4.9     30.3     0.89      28      4.9     32.0     0.89      54      4.6     31.7     0.84     102       
 23     5.8    31.3       4.6     30.2     0.79      27      4.7     33.1     0.81      49      4.2     32.6     0.72      91       
 24     6.2    30.4       4.3     30.9     0.69      24      4.3     33.9     0.69      45      4.8     33.4     0.77     101       
 25     5.1    31.5       4.8     32.7     0.94      26      4.5     35.0     0.88      45      4.1     33.7     0.80      86       
 26     5.6    31.8       4.5     33.6     0.80      24      4.4     35.8     0.79      43      4.5     33.9     0.80      93       
 27     4.9    31.5       4.7     33.9     0.96      24      4.0     37.2     0.82      38      4.6     35.0     0.94      93       
 28     5.3    31.3       4.3     34.0     0.81      22      3.5     37.5     0.66      33      4.6     34.8     0.87      93       
 29     5.4    32.7       4.6     34.2     0.85      24      3.6     37.9     0.67      34      4.8     35.1     0.89      95       
 30     5.5    32.9       4.3     34.6     0.78      22      4.1     38.1     0.75      38      4.2     33.2     0.76      89       
 31     5.2    32.6       4.6     34.0     0.88      23      4.0     38.3     0.77      37      3.9     33.1     0.75      83       
 32     4.5    32.9       4.7     32.2     1.04      26      3.6     36.6     0.80      34      4.9     32.9     1.09     105       
 33     4.5    32.9       5.3     32.0     1.18      29      3.7     37.7     0.82      34      4.4     32.9     0.98      93       
 34     5.9    33.2       4.9     33.3     0.83      26      3.8     36.6     0.64      37      4.4     33.3     0.75      93       
 35     4.9    33.5       4.8     33.7     0.98      25      4.2     38.3     0.86      39      5.4     32.3     1.10     117       
 36     5.5    32.7       5.3     34.0     0.96      27      4.6     39.2     0.84      41      5.1     33.0     0.93     108       
 37     5.0    33.3       5.2     32.8     1.04      28      4.5     41.0     0.90      38      4.8     33.2     0.96     101       
 38     5.6    34.8       5.3     33.5     0.95      28      4.5     42.3     0.80      38      5.0     32.8     0.89     107       
 39     6.1    35.3       5.1     34.2     0.84      26      4.9     42.7     0.80      40      4.4     33.2     0.72      93       
==================================================================================================================================  
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                                26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                             
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
 40     5.6    35.7       5.0     34.8     0.89      25      4.7     41.9     0.84      39      4.1     36.5     0.73      79       
 41     6.1    36.6       5.0     34.9     0.82      25      4.9     41.2     0.80      42      4.5     35.8     0.74      88       
 42     6.4    35.7       4.8     35.8     0.75      24      4.7     42.8     0.73      38      5.4     34.9     0.84     108       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    6.1    24.4       4.6     24.1     0.82      33      4.2     23.6     0.73      61      4.4     23.3     0.79     129       
SD(D)   1.2               0.9              0.18       4      0.9              0.14      12      1.4              0.22      34       
CV(E)  19.2              18.6             22.3     12.1     22.8             19.4     19.6     31.9             27.9     26.1       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    5.3    31.8       4.8     31.9     0.92      26      4.4     35.6     0.84      44      4.7     32.2     0.89     103       
SD(D)   0.6               0.3              0.12       3      0.5              0.12       9      0.4              0.13      15       
CV(E)  10.9               6.0             12.6      9.9     10.6             13.9     20.4      8.1             14.3     14.2       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                   DIAGNOSTIC TRAILER REPORT                                                                                        
                   WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                               
                   26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                                          
=========================================================================================================                           
           0 MG/L                  175 MG/L                 350 MG/L                 700 MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               22.4  10                 22.7  10                 23.2  10                 22.8  10                               
  1   8.7   280   22.4  10     2.4   585   22.7  10     1.0   576   23.2  10     0.8   646   22.8  10                               
  2   5.5   218   23.7  10     2.9  1671   24.0  10     2.5  1607   23.3  10     1.9  1678   20.6  10                               
  3   7.4   632   25.0  10     2.9  1613   26.1  10     2.8  1585   25.0  10     2.0  1608   23.8  10                               
  4   5.7   828   25.6  10     3.3  1650   27.5  10     2.9  1590   26.5  10     2.6  1665   25.6  10                               
  5   5.0   650   27.2  10     3.1  1690   28.6  10     2.7  1596   27.6  10     2.5  1141   26.3  10                               
  6   4.7   878   27.9  10     3.1  1582   29.1  10     2.8  1640   28.5  10     2.6  1360   27.0  10                               
  7   4.2   566   28.5  10     3.2  1515   29.4  10     2.9  1720   28.7  10     2.4  1490   27.6  10                               
  8   4.1   261   28.1  10     3.6  1650   30.6  10     3.1  1561   29.5  10     2.7  1556   27.4  10                               
  9   3.0   245   28.7  10     3.9  1654   32.0  10     3.1  1650   30.8  10     3.0  1650   28.7  10                               
 10   4.6   334   29.4  10     3.4  1680   33.1  10     3.1  1609   31.8  10     2.9  1534   29.5  10                               
 11   4.3   311   30.8  10     3.6  1690   33.5  10     3.1  1693   32.5  10     2.7  1497   30.5  10                               
 12   4.2   385   31.2  10     3.4  1680   34.0  10     3.3  1619   33.0  10     3.1  1615   31.3  10                               
 13   4.3   336   31.4  10     3.4  1581   33.9  10     3.3  1578   33.1  10     3.0  1480   30.4  10                               
 14   3.4   389   31.7  10     3.8  1633   34.7  10     3.1  1700   33.1  10     3.2  1700   30.7  10                               
 15   4.0   266   31.6  10     4.2  1650   34.6  10     3.5  1533   33.6  10     3.1  1568   31.0  10                               
 16   4.8   295   32.4  10     4.0  1639   35.2  10     3.2  1705   34.3  10     3.3  1506   31.9  10                               
 17   4.7   246   32.2  10     4.2  1680   35.5  10     3.3  1494   34.5  10     3.6  1610   32.5  10                               
 18   5.1   542   32.5  10     3.8  1554   36.0  10     3.6  1581   35.2  10     3.4  1511   32.3  10                               
 19   4.5   560   33.4  10     3.3  1705   36.3  10     3.3  1710   35.6  10     3.3  1705   33.2  10                               
 20   5.4   648   34.2  10     3.5  1246   39.1   9     3.3  1675   37.0  10     2.9  1679   34.3  10                               
 21   4.3   553   35.1  10     3.5  1516   39.2   9     3.4  1447   36.8  10     2.8  1690   33.0  10                               
 22   4.9   338   35.3  10     3.8  1521   40.2   9     3.7  1687   37.5  10     3.1  1644   35.1  10                               
 23   5.5   172   36.3   8     3.8  1507   40.5   9     3.8  1603   37.2  10     3.0  1672   35.2  10                               
 24   5.2   265   36.6   8     3.7  1512   41.6   9     3.5  1488   37.9  10     2.9  1685   36.0  10                               
 25   3.7   320   36.7   8     3.5  1381   42.0   9     3.5  1384   37.0  10     3.2  1675   36.2  10                               
 26   5.0   814   36.9   8     3.8  1516   42.2   9     3.2  1517   38.6  10     3.1  1680   36.7  10                               
 27   4.1   727   36.9   8     3.6  1373   42.2   9     3.5  1452   39.4   9     3.2  1378   35.4  10                               
 28   4.4   536   37.6   8     3.8  1432   42.4   9     3.4  1432   40.2   9     3.5  1550   35.0  10                               
 29   5.4   559   37.5   8     3.7  1503   42.9   9     3.6  1503   39.8   9     3.5  1479   35.1  10                               
 30   5.0   658   37.5   8     4.1  1485   42.6   9     4.0  1386   40.2   9     3.6  1386   36.3  10                               
 31   5.2   609   37.6   8     4.0  1526   42.8   9     3.7  1459   40.6   9     3.0  1495   36.6  10                               
 32   3.7   870   37.0   8     3.9  1439   43.1   9     3.6  1289   40.4   9     3.2  1442   37.1  10                               
 33   5.0   650   38.9   8     4.0  1512   42.8   9     3.5  1421   40.0   9     3.2  1680   37.5  10                               
 34   3.9  1094   37.6   8     3.6  1490   42.2   9     3.2  1489   40.5   9     3.1  1562   37.1  10                               
 35   4.2   964   37.2   8     3.9  1548   40.7   9     3.4  1477   40.3   9     3.2  1666   36.8  10                               
 36   4.0   642   35.8   8     3.9  1424   40.5   9     3.3  1277   39.5   8     3.6  1602   37.3  10                               
 37   4.5   826   37.2   7     3.8  1342   41.3   9     3.6  1084   38.8   8     3.4  1583   37.5  10                               
 38   4.7   973   38.2   7     3.9  1512   41.6   9     3.2  1344   39.1   8     3.4  1659   37.9  10                               
 39   4.1   845   38.9   7     3.8  1529   41.8   9     3.1  1356   39.3   8     3.0  1666   38.3  10                               
 40   4.2  1008   39.9   7     3.8  1513   42.0   9     3.4  1230   39.1   8     2.9  1397   38.1  10                               
 41   4.1   623   41.7   6     4.0  1507   40.8   9     3.4  1337   38.5   8     3.4  1483   37.8   9                               
 42   4.0   903   42.4   6     4.1  1425   41.8   9     3.2  1333   39.1   8     3.2  1262   38.3   9                               
 43   4.0   576                3.8   864                3.1   768                3.3   864                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           27.7                     29.6                     28.7                     27.0                                   
14 TO 52          36.4                     40.3                     38.0                     35.5                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                   DIAGNOSTIC TRAILER REPORT                                                                                        
                   WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                             
                   26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                                          
=========================================================================================================                           
           0 MG/L                  175 MG/L                 350 MG/L                 700 MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               19.2  10                 19.1  10                 18.9  10                 19.3  10                               
  1               19.2  10     2.3   621   19.1  10     1.4   621   18.9  10     0.9   621   19.3  10                               
  2   6.6   347   20.0  10     3.8  1670   20.6  10     3.3  1673   20.0  10     2.6  1650   18.8  10                               
  3   8.9   748   21.2  10     4.5  1680   22.2  10     4.5  1512   21.6  10     3.6  1605   20.8  10                               
  4   6.0   364   22.0  10     4.5  1521   22.9  10     4.1  1334   22.4  10     4.3  1333   21.9  10                               
  5   4.5   510   23.3  10     4.4  1625   23.7  10     4.2  1355   23.1  10     4.0  1343   23.2  10                               
  6   7.6    70   23.8  10     4.3  1333   24.0  10     4.6  1572   23.8  10     4.7  1331   23.1  10                               
  7   6.2   325   24.2  10     4.6  1428   23.8  10     4.5  1517   23.4  10     4.4  1127   23.3  10                               
  8   6.8   225   24.8  10     5.0  1324   25.1  10     5.0  1344   24.1  10     5.2  1068   24.5  10                               
  9   5.4   150   25.2  10     5.4  1317   25.9  10     4.0   919   24.7  10     5.2   733   24.8  10                               
 10   5.3   196   26.4  10     5.4  1176   26.1  10     5.0   864   25.4  10     5.1   840   24.8  10                               
 11   6.8   213   26.9  10     5.0  1304   27.0  10     4.8   818   26.5  10     6.1   894   25.8  10                               
 12   6.0   340   26.7  10     5.5  1333   26.2  10     4.6   700   26.2  10     5.7  1089   26.5  10                               
 13   5.0   734   27.3  10     5.1  1369   26.7  10     4.1   668   26.2  10     5.2  1097   26.8  10                               
 14   4.8   706   27.8  10     4.7  1385   27.1  10     4.4   776   27.1  10     5.1  1187   26.7  10                               
 15   5.1   523   28.1  10     4.7   994   27.3  10     4.9   763   27.9   9     5.1  1159   27.4  10                               
 16   4.1   288   28.9  10     4.6  1102   27.6  10     4.3   680   28.4   9     4.8  1222   27.6  10                               
 17   5.7   817   28.5  10     4.9  1317   27.9  10     4.8   787   29.2   9     4.8  1150   27.4  10                               
 18   5.1   767   28.2  10     5.0  1319   28.6  10     5.0   989   29.4   9     5.1  1057   27.8  10                               
 19   4.3   564   29.3   9     4.8  1370   29.0  10     5.1  1053   30.4   9     4.4  1365   29.2  10                               
 20   4.8   783   29.9   9     4.7  1341   29.8  10     4.1  1319   31.4   9     4.6  1435   29.6  10                               
 21   5.2   652   30.3   8     4.8  1210   29.5  10     4.9  1372   30.6   9     4.8  1446   30.5   9                               
 22   5.5   504   30.2   8     4.9  1689   30.3  10     4.9  1337   32.0   9     4.6  1352   31.7   9                               
 23   5.8   356   31.3   8     4.6  1536   30.2  10     4.7  1241   33.1   9     4.2   907   32.6   8                               
 24   6.2   576   30.4   8     4.3  1272   30.9  10     4.3  1175   33.9   9     4.8  1150   33.4   8                               
 25   5.1   598   31.5   8     4.8  1130   32.7   9     4.5  1337   35.0   9     4.1  1031   33.7   8                               
 26   5.6   556   31.8   8     4.5  1010   33.6   9     4.4  1396   35.8   9     4.5  1251   33.9   8                               
 27   4.9   476   31.5   8     4.7  1180   33.9   9     4.0  1371   37.2   9     4.6  1181   35.0   7                               
 28   5.3   724   31.3   8     4.3  1249   34.0   9     3.5  1352   37.5   9     4.6  1098   34.8   7                               
 29   5.4   524   32.7   8     4.6  1265   34.2   9     3.6  1383   37.9   9     4.8  1048   35.1   7                               
 30   5.5   448   32.9   8     4.3  1130   34.6   9     4.1  1480   38.1   9     4.2  1083   33.2   7                               
 31   5.2   617   32.6   8     4.6  1287   34.0   9     4.0  1320   38.3   9     3.9  1120   33.1   7                               
 32   4.5   390   32.9   8     4.7  1372   32.2   9     3.6  1172   36.6   9     4.9  1172   32.9   7                               
 33   4.5   745   32.9   8     5.3  1348   32.0   9     3.7  1439   37.7   9     4.4  1176   32.9   7                               
 34   5.9   763   33.2   7     4.9  1328   33.3   9     3.8  1356   36.6   9     4.4  1092   33.3   7                               
 35   4.9   416   33.5   7     4.8  1133   33.7   8     4.2  1376   38.3   8     5.4  1204   32.3   7                               
 36   5.5   734   32.7   7     5.3  1352   34.0   8     4.6  1265   39.2   8     5.1  1105   33.0   7                               
 37   5.0   830   33.3   7     5.2  1152   32.8   8     4.5   992   41.0   7     4.8   990   33.2   7                               
 38   5.6   654   34.8   6     5.3  1059   33.5   8     4.5   822   42.3   5     5.0  1008   32.8   7                               
 39   6.1   506   35.3   6     5.1  1262   34.2   8     4.9   677   42.7   5     4.4   848   33.2   7                               
 40   5.6   768   35.7   6     5.0  1158   34.8   8     4.7   555   41.9   4     4.1   576   36.5   5                               
 41   6.1   727   36.6   6     5.0  1055   34.9   8     4.9   669   41.2   4     4.5   720   35.8   5                               
 42   6.4   365   35.7   5     4.8  1167   35.8   8     4.7   600   42.8   4     5.4   598   34.9   5                               
 43   6.1   384                4.4   672                4.6   384                5.1   384                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           23.9                     24.1                     23.6                     23.3                                   
14 TO 52          31.8                     31.9                     35.6                     32.2                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.