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TDMS Study 97013-95 Pathology Tables

NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03
Route: DOSED WATER                                                                                                Time: 10:07:31

                                                           FINAL/MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03    
Route: DOSED WATER                                                                                                Time: 10:07:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2                         1            1                                     
    Moribund Sacrifice                                 3            2            5            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 5            8            4            4                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (10)         (10)         (10)         (10)                                   
      Necrosis                                         1 (10%)                                                                      
      Epithelium, Regeneration                         1 (10%)                                                                      
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 (10%)      3 (30%)      1 (10%)      1 (10%)                               
      Infiltration Cellular                            2 (20%)                                                                      
      Inflammation                                     5 (50%)     10 (100%)     8 (80%)      7 (70%)                               
      Necrosis                                         2 (20%)                   2 (20%)                                            
      Hepatocyte, Fatty Change                                      6 (60%)      6 (60%)      6 (60%)                               
      Hepatocyte, Vacuolization Cytoplasmic            5 (50%)      8 (80%)      8 (80%)      8 (80%)                               
   Mesentery                                          (1)          (1)                       (1)                                    
      Inflammation, Suppurative                        1 (100%)                                                                     
      Artery, Inflammation                                          1 (100%)                  1 (100%)                              
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Hyperkeratosis                                                             1 (10%)                                            
      Epithelium, Hyperplasia                          3 (30%)                   1 (10%)      1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 (10%)                                                                      
      Subcapsular, Hyperplasia                         6 (60%)      5 (50%)      7 (70%)      8 (80%)                               
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                             2 (20%)      3 (30%)      1 (10%)      2 (20%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03    
Route: DOSED WATER                                                                                                Time: 10:07:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 (10%)                                                                      
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Cyst                                                          1 (10%)      1 (10%)                                            
      Inflammation                                     2 (20%)      1 (10%)      1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)                                                                           
      Inflammation                                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Atrophy                                          2 (20%)      2 (20%)      1 (10%)      2 (20%)                               
      Cyst                                             1 (10%)      1 (10%)      1 (10%)                                            
      Inflammation                                                  2 (20%)                                                         
      Inflammation, Suppurative                        2 (20%)                                                                      
   Oviduct                                            (1)                                                                           
      Inflammation                                     1 (100%)                                                                     
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Inflammation                                     1 (10%)                   1 (10%)                                            
      Endometrium, Hyperplasia, Cystic                 7 (70%)      9 (90%)      6 (60%)      6 (60%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (2)                                                                           
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
        Cell                                           1 (50%)                                                                      
      Renal, Hyperplasia                               1 (50%)                                                                      
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                    1 (10%)                                            
      Hyperplasia                                                   1 (10%)      2 (20%)                                            
      Infiltration Cellular, Plasma Cell               1 (10%)      1 (10%)                   2 (20%)                               
   Lymph Node, Mesenteric                             (10)         (10)         (9)          (10)                                   
      Hematopoietic Cell Proliferation                 1 (10%)                                                                      
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                    1 (10%)      1 (10%)                               
      Hematopoietic Cell Proliferation                 3 (30%)      3 (30%)                   2 (20%)                               
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          4 (40%)      2 (20%)      2 (20%)      2 (20%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03    
Route: DOSED WATER                                                                                                Time: 10:07:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Cyst                                             3 (30%)      3 (30%)      3 (30%)      4 (40%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (8)          (8)          (8)          (6)                                    
      Abscess                                                       1 (13%)                                                         
      Hyperkeratosis                                                                          1 (17%)                               
      Hyperplasia, Focal                                                                      1 (17%)                               
      Ulcer                                                                                   1 (17%)                               
      Control Epidermis, Hyperplasia                                1 (13%)                                                         
      Epidermis, Hyperplasia, Focal                                                           1 (17%)                               
      Subcutaneous Tissue, Inflammation                             1 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Inflammation                                                               2 (20%)                                            
      Alveolar Epithelium, Hyperplasia                 1 (10%)                   2 (20%)      1 (10%)                               
      Perivascular, Inflammation                                    1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Casts Protein                                                 1 (10%)                   2 (20%)                               
      Cyst                                                          1 (10%)      5 (50%)      2 (20%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03    
Route: DOSED WATER                                                                                                Time: 10:07:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Hydronephrosis                                   2 (20%)                                                                      
      Infarct                                                                    1 (10%)                                            
      Inflammation                                     1 (10%)                                                                      
      Mineralization                                                                          1 (10%)                               
      Nephropathy                                      4 (40%)      2 (20%)      4 (40%)      2 (20%)                               
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                          1 (10%)                                1 (10%)                               
      Renal Tubule, Accumulation, Hyaline Droplet      1 (10%)                                                                      
      Renal Tubule, Hypertrophy                                                  2 (20%)      1 (10%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03    
Route: DOSED WATER                                                                                                Time: 10:07:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4                                      1                                     
    Natural Death                                                   1            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 6            9            8            9                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                                                    (1)                                                 
      Inflammation                                                               1 (100%)                                           
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              1 (10%)      1 (10%)      1 (10%)                               
      Inflammation                                     5 (50%)      4 (40%)      8 (80%)      7 (70%)                               
      Necrosis                                                                   1 (10%)      1 (10%)                               
      Hepatocyte, Fatty Change                                      3 (30%)      2 (20%)                                            
      Hepatocyte, Vacuolization Cytoplasmic            7 (70%)      9 (90%)      8 (80%)      8 (80%)                               
   Mesentery                                          (1)                       (1)                                                 
      Fat, Necrosis                                    1 (100%)                  1 (100%)                                           
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Hyperkeratosis                                                1 (10%)                                                         
      Epithelium, Hyperplasia                          1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hypertrophy                                      5 (50%)      4 (40%)      4 (40%)      4 (40%)                               
      Subcapsular, Hyperplasia                         1 (10%)      1 (10%)      2 (20%)                                            
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                             2 (20%)      3 (30%)      1 (10%)                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Cyst                                             2 (20%)      2 (20%)      1 (10%)      2 (20%)                               
      Follicle, Cyst                                                1 (10%)                   1 (10%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03    
Route: DOSED WATER                                                                                                Time: 10:07:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (1)                                                                           
      Duct, Ectasia                                    1 (100%)                                                                     
   Testes                                             (10)         (10)         (10)         (10)                                   
      Mineralization                                   2 (20%)                                                                      
      Germinal Epithelium, Degeneration                3 (30%)                   1 (10%)      1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Angiectasis                                                                1 (10%)                                            
      Hyperplasia                                                                1 (10%)                                            
      Infiltration Cellular, Plasma Cell               1 (10%)      1 (10%)      1 (10%)      2 (20%)                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                       1 (10%)                                                         
      Hematopoietic Cell Proliferation                              1 (10%)      1 (10%)      1 (10%)                               
   Thymus                                             (9)          (9)          (10)         (10)                                   
      Atrophy                                          1 (11%)      1 (11%)      1 (10%)                                            
      Cyst                                             2 (22%)      3 (33%)      4 (40%)      5 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (8)          (8)          (8)          (8)                                    
      Hyperplasia                                                   2 (25%)      1 (13%)      1 (13%)                               
      Inflammation                                     1 (13%)                                                                      
      Control Epidermis, Hyperplasia                   2 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-95         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 10/08/03    
Route: DOSED WATER                                                                                                Time: 10:07:31    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Histiocyte                1 (10%)                                                                      
      Inflammation                                                  2 (20%)      1 (10%)                                            
      Alveolar Epithelium, Hyperplasia                 1 (10%)                                1 (10%)                               
      Perivascular, Inflammation                                                 1 (10%)      3 (30%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Casts Protein                                    2 (20%)                   1 (10%)      4 (40%)                               
      Cyst                                             3 (30%)      1 (10%)      1 (10%)                                            
      Hydronephrosis                                   1 (10%)                   2 (20%)                                            
      Infiltration Cellular, Plasma Cell                                         1 (10%)                                            
      Mineralization                                                                          2 (20%)                               
      Nephropathy                                      4 (40%)      7 (70%)      8 (80%)      9 (90%)                               
      Artery, Inflammation                                          1 (10%)                                                         
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                                                                 1 (10%)                               
      Renal Tubule, Degeneration                                                 2 (20%)      6 (60%)                               
      Renal Tubule, Dilatation                         1 (10%)      8 (80%)      8 (80%)     10 (100%)                              
      Renal Tubule, Hypertrophy                                                               1 (10%)                               
      Renal Tubule, Vacuolization Cytoplasmic          1 (10%)                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
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