National Toxicology Program

National Toxicology Program
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TDMS Study 97013-98 Pathology Tables

NTP  EXP/TEST: 97013-98                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 1
TEST TYPE: 26-39 WEEKS                          INITIAL AND CURRENT BODY WEIGHT                                   DATE: 11/04/03
ROUTE: GAVAGE                                                                                                     TIME: 12:14:15

                                                         EIS REPORT 03


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013K

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  75-27-4

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-98                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 2
TEST TYPE: 26-39 WEEKS                          INITIAL AND CURRENT BODY WEIGHT                                   DATE: 11/04/03
ROUTE: GAVAGE                                               EISRPT03                                              TIME: 12:14:15
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 SPECIES-STRAIN: P53(C57BL/6)-MICE          SEX: FEMALE      WEEK ON DOSE: 42     FIRST DOSE: 09/16/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            10     19.3    1.3         9     38.8    8.9                      9     19.5    7.9

 25 MG/KG           10     18.9    1.1         9     34.5    8.6        88.9          9     15.6    7.7

 50 MG/KG           10     19.4    1.4         8     36.4    6.9        93.8          8     16.8    5.8

 100     MG/KG      10     19.2    1.0         9     35.2    8.9        90.7          9     16.0    8.0




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 SPECIES-STRAIN: P53(C57BL/6)-MICE          SEX: MALE        WEEK ON DOSE: 42     FIRST DOSE: 09/16/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            10     23.7    1.4        10     50.5    4.5                     10     26.7    4.3

 25 MG/KG           10     23.4    1.5         9     46.6    5.0        92.2          9     23.3    4.2

 50 MG/KG           10     23.4    1.8        10     43.8    7.4        86.7         10     20.5    6.4

 100     MG/KG      10     23.5    1.8        10     40.2    4.5        79.6         10     16.7    3.7

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