National Toxicology Program

National Toxicology Program
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TDMS Study 97013-99 Pathology Tables

NTP  EXP/TEST: 97013-99                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 11/05/03
ROUTE: SKIN APPLICATION                                                                                           TIME: 09:56:54

                                                         EIS REPORT 03


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013F

       CONTRACT NUMBER:  NO1-ES-65406

       CAS NUMBER:  75-27-4

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-99                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 11/05/03
ROUTE: SKIN APPLICATION                                     EISRPT03                                              TIME: 09:56:54
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 SPECIES-STRAIN: TG.AC HEMI-MICE            SEX: FEMALE      WEEK ON DOSE: 40     FIRST DOSE: 08/19/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            10     20.0    1.2         5     27.7    3.0                      5      7.9    3.8

 64 MG/KG           10     20.2    0.8         4     27.9    2.6       100.7          4      8.1    1.7

 128     MG/KG      10     20.0    0.9         7     32.2    6.2       116.2          7     11.9    5.7

 256     MG/KG      10     20.1    1.1         5     28.8    2.3       103.9          5      8.1    2.4




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 SPECIES-STRAIN: TG.AC HEMI-MICE            SEX: MALE        WEEK ON DOSE: 40     FIRST DOSE: 08/19/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            10     24.1    1.2         6     37.7    5.1                      6     13.2    4.9

 64 MG/KG           10     24.5    1.0         8     39.0    5.4       103.4          8     14.4    4.8

 128     MG/KG      10     24.4    0.8         9     37.4    5.2        99.2          9     12.8    5.2

 256     MG/KG      10     24.9    1.0         8     35.6    4.8        94.4          8     10.7    4.8

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