National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/18429

TDMS Study 96021-01 Pathology Tables

NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 06/05/03
Route: GAVAGE                                                                                                     Time: 10:44:59

                                                      31 WEEK SSAC FINAL#1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  35065-27-1

       Lock Date:  01/16/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     03/22/99 - 03/23/99

       Treatment Groups:       Include 001    0 UG/KG
                               Include 002    10 UG/KG
                               Include 003    100     UG/KG
                               Include 004    300     UG/KG
                               Include 005    1000    UG/KG
                               Include 006    3000    UG/KG





























a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 06/05/03    
Route: GAVAGE                                                                                                     Time: 10:44:59    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           86           98           98           98           80           
                                                                                                                                    
  Scheduled Sacrifice                                 16           10           16           16           16           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Eosinophilic Focus                               1 (10%)                                                          1 (10%)     
      Inflammation                                     9 (90%)     10 (100%)    10 (100%)     9 (90%)     10 (100%)    10 (100%)    
      Mixed Cell Focus                                 1 (10%)      1 (10%)      4 (40%)      2 (20%)      2 (20%)                  
      Mixed Cell Focus, Multiple                       1 (10%)                                                          1 (10%)     
      Bile Duct, Hyperplasia                                                                                            1 (10%)     
      Hepatocyte, Hypertrophy                          1 (10%)      1 (10%)                   7 (70%)      9 (90%)     10 (100%)    
   Pancreas                                           (10)                                                             (10)         
      Inflammation, Chronic Active                     1 (10%)                                                                      
      Acinus, Atrophy                                  1 (10%)                                                                      
   Stomach, Glandular                                 (10)                                                             (10)         
      Dysplasia                                                                                                         1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)                                                             (10)         
      Hypertrophy                                      3 (30%)                                                          2 (20%)     
      Vacuolization Cytoplasmic                        1 (10%)                                                          3 (30%)     
   Thyroid Gland                                      (10)         (10)         (10)         (10)         (10)         (10)         
      Follicular Cell, Hypertrophy                     2 (20%)      1 (10%)      1 (10%)      2 (20%)                   1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 06/05/03    
Route: GAVAGE                                                                                                     Time: 10:44:59    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)                                                             (10)         
      Atrophy                                          7 (70%)                                                          7 (70%)     
   Uterus                                             (10)                                   (1)                       (10)         
      Inflammation, Suppurative                        1 (10%)                                1 (100%)                  3 (30%)     
      Metaplasia, Squamous                             7 (70%)                                1 (100%)                  5 (50%)     
      Endometrium, Hyperplasia, Cystic                 2 (20%)                                1 (100%)                  1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (10)                                                             (10)         
      Pigmentation                                    10 (100%)                                                        10 (100%)    
   Thymus                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                          1 (10%)      2 (20%)                   1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Infiltration Cellular, Histiocyte                             1 (10%)                                                         
      Alveolar Epithelium, Hyperplasia                                                        1 (10%)                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96021-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153)                       Date: 06/05/03    
Route: GAVAGE                                                                                                     Time: 10:44:59    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 UG/KG      10 UG/KG     100          300          1000         3000            
                                                                             UG/KG        UG/KG        UG/KG        UG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                      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