https://ntp.niehs.nih.gov/go/16009

TDMS Study 60855-01 Pathology Tables

NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04
Route: GAVAGE                                                                                                     Time: 14:10:50
       Facility:  BIORELIANCE
       Chemical CAS #:  7166-19-0
       Lock Date:  04/23/92
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      0.037        0.037        0.075        0.075           
                                                                                          G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Scheduled Sacrifice                                              10                        10                        10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10                        10                        10                        
  Animals Examined Microscopically                    10                        10                        10                        
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)                      (1)                       (3)                       
      Hepatodiaphragmatic Nodule                                                 1 (100%)                  3 (100%)                 
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)                                                                          
      Inflammation                                     1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Clitoral Gland                                     (10)                                                                          
      Inflammation                                     3 (30%)                                                                      
   Uterus                                             (10)                      (1)                                                 
      Bilateral, Hydrometra                            2 (20%)                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      0.037        0.037        0.075        0.075           
                                                                                          G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Nose                                               (10)                      (10)                      (10)                      
      Foreign Body                                     1 (10%)                                                                      
      Inflammation                                     1 (10%)                   3 (30%)                   4 (40%)                  
      Olfactory Epithelium, Degeneration                                         3 (30%)                                            
      Olfactory Epithelium, Metaplasia                                                                     1 (10%)                  
      Respiratory Epithelium, Degeneration                                       1 (10%)                   1 (10%)                  
      Respiratory Epithelium, Metaplasia, Squamous                                                         1 (10%)                  
      Respiratory Epithelium, Necrosis                                                                     1 (10%)                  
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)                                                                          
      Mineralization                                   4 (40%)                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG         G/KG         G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Scheduled Sacrifice                                              10                        10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                           1                         7            6           
    Natural Death                                                                                          3            4           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10                         9                                                  
  Animals Examined Microscopically                    10                        10                        10                        
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Cecum                             (10)                      (10)                      (10)                      
      Inflammation                                                               8 (80%)                   1 (10%)                  
   Liver                                              (1)                       (10)                      (10)                      
      Congestion                                                                 1 (10%)                                            
      Cytoplasmic Alteration                                                     1 (10%)                                            
      Hepatodiaphragmatic Nodule                       1 (100%)                                                                     
      Inflammation                                                                                         2 (20%)                  
      Necrosis, Focal                                                                                      2 (20%)                  
      Centrilobular, Vacuolization Cytoplasmic                                                             1 (10%)                  
   Pancreas                                                                     (10)                      (10)                      
      Inflammation                                                                                         3 (30%)                  
   Stomach, Forestomach                               (10)                      (10)                      (10)                      
      Hemorrhage                                                                                           4 (40%)                  
      Inflammation                                                               7 (70%)                   9 (90%)                  
      Necrosis                                                                                             8 (80%)                  
      Ulcer                                                                      3 (30%)                                            
      Epithelium, Hyperkeratosis                      10 (100%)                  8 (80%)                                            
      Epithelium, Hyperplasia                          8 (80%)                  10 (100%)                                           
   Stomach, Glandular                                 (10)                      (10)                      (10)                      
      Inflammation                                                                                         6 (60%)                  
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                                                        (10)                      (10)                      
      Hemorrhage                                                                                           1 (10%)                  
      Inflammation                                                               1 (10%)                                            
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG         G/KG         G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Medulla                                                              (10)                      (7)                       
      Degeneration                                                               1 (10%)                                            
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Clitoral Gland                                                               (10)                      (10)                      
      Inflammation                                                               5 (50%)                   1 (10%)                  
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                                                  (10)                      (10)                      
      Depletion Cellular                                                         1 (10%)                                            
      Hemorrhage                                                                 1 (10%)                   1 (10%)                  
      Myeloid Cell, Hyperplasia                                                  1 (10%)                                            
   Lymph Node, Mandibular                                                       (9)                       (10)                      
      Hemorrhage                                                                 2 (22%)                                            
      Hyperplasia, Lymphoid                                                      1 (11%)                                            
   Lymph Node, Mesenteric                                                       (10)                      (10)                      
      Atrophy                                                                    1 (10%)                                            
      Hemorrhage                                                                 1 (10%)                   7 (70%)                  
   Spleen                                                                       (10)                      (10)                      
      Atrophy                                                                    1 (10%)                                            
      Inflammation                                                                                         2 (20%)                  
   Thymus                                                                       (10)                      (10)                      
      Atrophy                                                                    1 (10%)                   2 (20%)                  
      Hemorrhage                                                                                           2 (20%)                  
      Necrosis                                                                   1 (10%)                   1 (10%)                  
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG         G/KG         G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Skeletal Muscle                                    (1)                                                                           
      Atrophy, Focal                                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                                                         (10)                      (10)                      
      Congestion                                                                                           3 (30%)                  
      Hemorrhage                                                                 2 (20%)                   1 (10%)                  
      Inflammation                                                               1 (10%)                                            
   Nose                                               (10)                      (10)                      (10)                      
      Inflammation                                     6 (60%)                   3 (30%)                   1 (10%)                  
      Necrosis                                                                   2 (20%)                                            
      Olfactory Epithelium, Degeneration                                         2 (20%)                                            
      Olfactory Epithelium, Metaplasia                 1 (10%)                                                                      
      Olfactory Epithelium, Necrosis                   1 (10%)                                                                      
      Respiratory Epithelium, Degeneration             1 (10%)                   1 (10%)                                            
      Respiratory Epithelium, Metaplasia, Squamous     4 (40%)                   2 (20%)                                            
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                                                       (10)                      (10)                      
      Mineralization                                                             5 (50%)                   7 (70%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      0.037        0.037        0.075        0.075           
                                                                             G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Scheduled Sacrifice                                              10                        10                        10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10                        10                        10                        
  Animals Examined Microscopically                    10                        10                        10                        
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Cecum                             (10)                      (10)                      (10)                      
      Inflammation                                                               1 (10%)                   4 (40%)                  
   Liver                                              (10)                                                (1)                       
      Hepatodiaphragmatic Nodule                                                                           1 (100%)                 
   Stomach, Forestomach                               (10)                      (10)                      (10)                      
      Epithelium, Hyperkeratosis                                                                           4 (40%)                  
      Epithelium, Hyperplasia                                                                              3 (30%)                  
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)                                                                          
      Inflammation                                     3 (30%)                                                                      
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Preputial Gland                                    (10)                                                                          
      Inflammation                                     2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      0.037        0.037        0.075        0.075           
                                                                             G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Thymus                                             (10)                                                                          
      Hemorrhage                                       2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)                                                                          
      Hemorrhage                                       3 (30%)                                                                      
      Inflammation, Focal                              3 (30%)                                                                      
   Nose                                               (10)                      (10)                      (10)                      
      Inflammation                                     2 (20%)                   1 (10%)                   2 (20%)                  
      Olfactory Epithelium, Degeneration                                                                   2 (20%)                  
      Respiratory Epithelium, Metaplasia, Squamous     1 (10%)                   1 (10%)                                            
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG                      G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Scheduled Sacrifice                                              10                         8                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2                                                   4            2           
    Natural Death                                                                1            2            6            8           
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8                         9                                                  
  Animals Examined Microscopically                    10                        10                        10                        
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Colon                             (2)                       (10)                      (9)                       
      Inflammation                                     1 (50%)                                                                      
   Intestine Large, Cecum                             (10)                      (10)                      (8)                       
      Inflammation                                     6 (60%)                   9 (90%)                   2 (25%)                  
   Intestine Small, Jejunum                           (2)                       (10)                      (7)                       
      Inflammation                                     1 (50%)                                                                      
   Intestine Small, Ileum                             (2)                       (10)                      (9)                       
      Inflammation                                     1 (50%)                                                                      
   Liver                                              (2)                       (10)                      (10)                      
      Congestion                                                                                           1 (10%)                  
      Inflammation                                                               1 (10%)                                            
      Centrilobular, Necrosis                                                    1 (10%)                                            
      Centrilobular, Vacuolization Cytoplasmic                                   1 (10%)                                            
   Pancreas                                           (2)                       (10)                      (10)                      
      Inflammation                                                                                         1 (10%)                  
   Stomach, Forestomach                               (10)                      (10)                      (10)                      
      Foreign Body                                                               1 (10%)                                            
      Hemorrhage                                                                                           6 (60%)                  
      Inflammation                                                               4 (40%)                   9 (90%)                  
      Necrosis                                                                   1 (10%)                   3 (30%)                  
      Ulcer                                                                      3 (30%)                                            
      Epithelium, Hyperkeratosis                       9 (90%)                   9 (90%)                                            
      Epithelium, Hyperplasia                          7 (70%)                  10 (100%)                                           
   Stomach, Glandular                                 (10)                      (10)                      (10)                      
      Congestion                                                                                           1 (10%)                  
      Hemorrhage                                                                                           1 (10%)                  
      Inflammation                                                                                         4 (40%)                  
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG                      G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (2)                       (10)                      (10)                      
      Inflammation                                                               1 (10%)                                            
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Preputial Gland                                    (2)                       (10)                      (10)                      
      Inflammation                                                               1 (10%)                   4 (40%)                  
   Prostate                                           (2)                       (10)                      (10)                      
      Inflammation                                                                                         2 (20%)                  
   Testes                                             (10)                      (10)                      (10)                      
      Degeneration                                     2 (20%)                   1 (10%)                   9 (90%)                  
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (2)                       (10)                      (10)                      
      Depletion Cellular                                                         1 (10%)                   1 (10%)                  
      Hyperplasia                                                                                          1 (10%)                  
      Myeloid Cell, Depletion Cellular                                           1 (10%)                                            
      Myeloid Cell, Hyperplasia                                                  1 (10%)                                            
   Lymph Node, Mandibular                             (2)                       (10)                      (9)                       
      Hemorrhage                                       1 (50%)                   1 (10%)                                            
      Hyperplasia, Lymphoid                                                      2 (20%)                                            
      Hyperplasia, Plasma Cell                         1 (50%)                                                                      
   Lymph Node, Mesenteric                             (2)                       (10)                      (10)                      
      Hemorrhage                                                                 2 (20%)                   4 (40%)                  
   Spleen                                             (2)                       (10)                      (10)                      
      Atrophy                                          1 (50%)                                                                      
      Congestion                                                                 1 (10%)                                            
      Lymphoid Follicle, Depletion Cellular                                                                2 (20%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG                      G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Thymus                                             (3)                       (10)                      (10)                      
      Atrophy                                          1 (33%)                                             4 (40%)                  
      Hemorrhage                                                                 3 (30%)                   5 (50%)                  
      Necrosis                                                                                             1 (10%)                  
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (2)                       (10)                      (10)                      
      Congestion                                                                                           1 (10%)                  
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (2)                       (10)                      (10)                      
      Congestion                                                                                           4 (40%)                  
      Hemorrhage                                                                 2 (20%)                   3 (30%)                  
      Inflammation                                                                                         1 (10%)                  
   Nose                                               (10)                      (10)                      (10)                      
      Congestion                                                                                           2 (20%)                  
      Hemorrhage                                       1 (10%)                                                                      
      Inflammation                                     6 (60%)                   2 (20%)                   4 (40%)                  
      Necrosis                                                                   1 (10%)                   2 (20%)                  
      Olfactory Epithelium, Degeneration               2 (20%)                   1 (10%)                                            
      Respiratory Epithelium, Degeneration             1 (10%)                                                                      
      Respiratory Epithelium, Metaplasia, Squamous     1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG                      G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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