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TDMS Study 60855-01 Pathology Tables

NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04
Route: GAVAGE                                                                                                     Time: 14:10:50




       Facility:  BIORELIANCE

       Chemical CAS #:  7166-19-0

       Lock Date:  04/23/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      0.037        0.037        0.075        0.075           
                                                                                          G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
                                                                                                                                    
  Scheduled Sacrifice                                              10                        10                        10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10                        10                        10                        
                                                                                                                                    
  Animals Examined Microscopically                    10                        10                        10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                      (1)                       (3)                       
      Hepatodiaphragmatic Nodule                                                 1 (100%)                  3 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                                          
      Inflammation                                     1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (10)                                                                          
      Inflammation                                     3 (30%)                                                                      
   Uterus                                             (10)                      (1)                                                 
      Bilateral, Hydrometra                            2 (20%)                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      CONTROL      0.037        0.037        0.075        0.075           
                                                                                          G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Nose                                               (10)                      (10)                      (10)                      
      Foreign Body                                     1 (10%)                                                                      
      Inflammation                                     1 (10%)                   3 (30%)                   4 (40%)                  
      Olfactory Epithelium, Degeneration                                         3 (30%)                                            
      Olfactory Epithelium, Metaplasia                                                                     1 (10%)                  
      Respiratory Epithelium, Degeneration                                       1 (10%)                   1 (10%)                  
      Respiratory Epithelium, Metaplasia, Squamous                                                         1 (10%)                  
      Respiratory Epithelium, Necrosis                                                                     1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                                          
      Mineralization                                   4 (40%)                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG         G/KG         G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
                                                                                                                                    
  Scheduled Sacrifice                                              10                        10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                           1                         7            6           
    Natural Death                                                                                          3            4           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10                         9                                                  
                                                                                                                                    
  Animals Examined Microscopically                    10                        10                        10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (10)                      (10)                      (10)                      
      Inflammation                                                               8 (80%)                   1 (10%)                  
   Liver                                              (1)                       (10)                      (10)                      
      Congestion                                                                 1 (10%)                                            
      Cytoplasmic Alteration                                                     1 (10%)                                            
      Hepatodiaphragmatic Nodule                       1 (100%)                                                                     
      Inflammation                                                                                         2 (20%)                  
      Necrosis, Focal                                                                                      2 (20%)                  
      Centrilobular, Vacuolization Cytoplasmic                                                             1 (10%)                  
   Pancreas                                                                     (10)                      (10)                      
      Inflammation                                                                                         3 (30%)                  
   Stomach, Forestomach                               (10)                      (10)                      (10)                      
      Hemorrhage                                                                                           4 (40%)                  
      Inflammation                                                               7 (70%)                   9 (90%)                  
      Necrosis                                                                                             8 (80%)                  
      Ulcer                                                                      3 (30%)                                            
      Epithelium, Hyperkeratosis                      10 (100%)                  8 (80%)                                            
      Epithelium, Hyperplasia                          8 (80%)                  10 (100%)                                           
   Stomach, Glandular                                 (10)                      (10)                      (10)                      
      Inflammation                                                                                         6 (60%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                                                        (10)                      (10)                      
      Hemorrhage                                                                                           1 (10%)                  
      Inflammation                                                               1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG         G/KG         G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Medulla                                                              (10)                      (7)                       
      Degeneration                                                               1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                               (10)                      (10)                      
      Inflammation                                                               5 (50%)                   1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                                                  (10)                      (10)                      
      Depletion Cellular                                                         1 (10%)                                            
      Hemorrhage                                                                 1 (10%)                   1 (10%)                  
      Myeloid Cell, Hyperplasia                                                  1 (10%)                                            
   Lymph Node, Mandibular                                                       (9)                       (10)                      
      Hemorrhage                                                                 2 (22%)                                            
      Hyperplasia, Lymphoid                                                      1 (11%)                                            
   Lymph Node, Mesenteric                                                       (10)                      (10)                      
      Atrophy                                                                    1 (10%)                                            
      Hemorrhage                                                                 1 (10%)                   7 (70%)                  
   Spleen                                                                       (10)                      (10)                      
      Atrophy                                                                    1 (10%)                                            
      Inflammation                                                                                         2 (20%)                  
   Thymus                                                                       (10)                      (10)                      
      Atrophy                                                                    1 (10%)                   2 (20%)                  
      Hemorrhage                                                                                           2 (20%)                  
      Necrosis                                                                   1 (10%)                   1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG         G/KG         G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
      Atrophy, Focal                                   1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                                                         (10)                      (10)                      
      Congestion                                                                                           3 (30%)                  
      Hemorrhage                                                                 2 (20%)                   1 (10%)                  
      Inflammation                                                               1 (10%)                                            
   Nose                                               (10)                      (10)                      (10)                      
      Inflammation                                     6 (60%)                   3 (30%)                   1 (10%)                  
      Necrosis                                                                   2 (20%)                                            
      Olfactory Epithelium, Degeneration                                         2 (20%)                                            
      Olfactory Epithelium, Metaplasia                 1 (10%)                                                                      
      Olfactory Epithelium, Necrosis                   1 (10%)                                                                      
      Respiratory Epithelium, Degeneration             1 (10%)                   1 (10%)                                            
      Respiratory Epithelium, Metaplasia, Squamous     4 (40%)                   2 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                                                       (10)                      (10)                      
      Mineralization                                                             5 (50%)                   7 (70%)                  
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      0.037        0.037        0.075        0.075           
                                                                             G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
                                                                                                                                    
  Scheduled Sacrifice                                              10                        10                        10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10                        10                        10                        
                                                                                                                                    
  Animals Examined Microscopically                    10                        10                        10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (10)                      (10)                      (10)                      
      Inflammation                                                               1 (10%)                   4 (40%)                  
   Liver                                              (10)                                                (1)                       
      Hepatodiaphragmatic Nodule                                                                           1 (100%)                 
   Stomach, Forestomach                               (10)                      (10)                      (10)                      
      Epithelium, Hyperkeratosis                                                                           4 (40%)                  
      Epithelium, Hyperplasia                                                                              3 (30%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                                          
      Inflammation                                     3 (30%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)                                                                          
      Inflammation                                     2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      CONTROL      0.037        0.037        0.075        0.075           
                                                                             G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Thymus                                             (10)                                                                          
      Hemorrhage                                       2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                                          
      Hemorrhage                                       3 (30%)                                                                      
      Inflammation, Focal                              3 (30%)                                                                      
   Nose                                               (10)                      (10)                      (10)                      
      Inflammation                                     2 (20%)                   1 (10%)                   2 (20%)                  
      Olfactory Epithelium, Degeneration                                                                   2 (20%)                  
      Respiratory Epithelium, Metaplasia, Squamous     1 (10%)                   1 (10%)                                            
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG                      G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
                                                                                                                                    
  Scheduled Sacrifice                                              10                         8                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2                                                   4            2           
    Natural Death                                                                1            2            6            8           
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8                         9                                                  
                                                                                                                                    
  Animals Examined Microscopically                    10                        10                        10                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (2)                       (10)                      (9)                       
      Inflammation                                     1 (50%)                                                                      
   Intestine Large, Cecum                             (10)                      (10)                      (8)                       
      Inflammation                                     6 (60%)                   9 (90%)                   2 (25%)                  
   Intestine Small, Jejunum                           (2)                       (10)                      (7)                       
      Inflammation                                     1 (50%)                                                                      
   Intestine Small, Ileum                             (2)                       (10)                      (9)                       
      Inflammation                                     1 (50%)                                                                      
   Liver                                              (2)                       (10)                      (10)                      
      Congestion                                                                                           1 (10%)                  
      Inflammation                                                               1 (10%)                                            
      Centrilobular, Necrosis                                                    1 (10%)                                            
      Centrilobular, Vacuolization Cytoplasmic                                   1 (10%)                                            
   Pancreas                                           (2)                       (10)                      (10)                      
      Inflammation                                                                                         1 (10%)                  
   Stomach, Forestomach                               (10)                      (10)                      (10)                      
      Foreign Body                                                               1 (10%)                                            
      Hemorrhage                                                                                           6 (60%)                  
      Inflammation                                                               4 (40%)                   9 (90%)                  
      Necrosis                                                                   1 (10%)                   3 (30%)                  
      Ulcer                                                                      3 (30%)                                            
      Epithelium, Hyperkeratosis                       9 (90%)                   9 (90%)                                            
      Epithelium, Hyperplasia                          7 (70%)                  10 (100%)                                           
   Stomach, Glandular                                 (10)                      (10)                      (10)                      
      Congestion                                                                                           1 (10%)                  
      Hemorrhage                                                                                           1 (10%)                  
      Inflammation                                                                                         4 (40%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG                      G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (2)                       (10)                      (10)                      
      Inflammation                                                               1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (2)                       (10)                      (10)                      
      Inflammation                                                               1 (10%)                   4 (40%)                  
   Prostate                                           (2)                       (10)                      (10)                      
      Inflammation                                                                                         2 (20%)                  
   Testes                                             (10)                      (10)                      (10)                      
      Degeneration                                     2 (20%)                   1 (10%)                   9 (90%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (2)                       (10)                      (10)                      
      Depletion Cellular                                                         1 (10%)                   1 (10%)                  
      Hyperplasia                                                                                          1 (10%)                  
      Myeloid Cell, Depletion Cellular                                           1 (10%)                                            
      Myeloid Cell, Hyperplasia                                                  1 (10%)                                            
   Lymph Node, Mandibular                             (2)                       (10)                      (9)                       
      Hemorrhage                                       1 (50%)                   1 (10%)                                            
      Hyperplasia, Lymphoid                                                      2 (20%)                                            
      Hyperplasia, Plasma Cell                         1 (50%)                                                                      
   Lymph Node, Mesenteric                             (2)                       (10)                      (10)                      
      Hemorrhage                                                                 2 (20%)                   4 (40%)                  
   Spleen                                             (2)                       (10)                      (10)                      
      Atrophy                                          1 (50%)                                                                      
      Congestion                                                                 1 (10%)                                            
      Lymphoid Follicle, Depletion Cellular                                                                2 (20%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG                      G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Thymus                                             (3)                       (10)                      (10)                      
      Atrophy                                          1 (33%)                                             4 (40%)                  
      Hemorrhage                                                                 3 (30%)                   5 (50%)                  
      Necrosis                                                                                             1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (2)                       (10)                      (10)                      
      Congestion                                                                                           1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (2)                       (10)                      (10)                      
      Congestion                                                                                           4 (40%)                  
      Hemorrhage                                                                 2 (20%)                   3 (30%)                  
      Inflammation                                                                                         1 (10%)                  
   Nose                                               (10)                      (10)                      (10)                      
      Congestion                                                                                           2 (20%)                  
      Hemorrhage                                       1 (10%)                                                                      
      Inflammation                                     6 (60%)                   2 (20%)                   4 (40%)                  
      Necrosis                                                                   1 (10%)                   2 (20%)                  
      Olfactory Epithelium, Degeneration               2 (20%)                   1 (10%)                                            
      Respiratory Epithelium, Degeneration             1 (10%)                                                                      
      Respiratory Epithelium, Metaplasia, Squamous     1 (10%)                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:10:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0.150        0.150        0.300        0.300        0.600        0.600           
                                                   G/KG                      G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                      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