https://ntp.niehs.nih.gov/go/18193

TDMS Study 88138-01 Pathology Tables

NTP Experiment-Test: 88138-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                    BENZOPHENONE                                       Date: 10/25/04
Route: DOSED FEED                                                                                                 Time: 13:28:04
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  119-61-9
       Lock Date:  08/17/93
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 88138-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                    BENZOPHENONE                                       Date: 10/25/04    
Route: DOSED FEED                                                                                                 Time: 13:28:04    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0%           0.125%       0.25%        0.5%         1.0%         2.0%            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                                                                  9           
    Natural Death                                                                                                       1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10                        
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Cecum                             (9)                                                 (10)         (9)          
      Inflammation, Chronic Active                     1 (11%)                                                                      
   Liver                                              (10)         (10)         (10)         (10)         (10)         (9)          
      Hepatodiaphragmatic Nodule                       1 (10%)      4 (40%)      2 (20%)      3 (30%)      1 (10%)      2 (22%)     
      Inflammation, Chronic Active                     3 (30%)                                                                      
      Inflammation, Granulomatous                      2 (20%)      4 (40%)                                                         
      Hepatocyte, Hypertrophy                                       2 (20%)      8 (80%)     10 (100%)    10 (100%)     7 (78%)     
      Hepatocyte, Vacuolization Cytoplasmic                                                   9 (90%)     10 (100%)     7 (78%)     
   Mesentery                                          (1)                       (1)                                    (1)          
      Inflammation, Granulomatous                                                1 (100%)                                           
      Necrosis                                                                   1 (100%)                                           
      Fat, Inflammation, Chronic Active                1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)                                                (10)         (9)          
      Myocardium, Inflammation, Chronic Active                                                             1 (10%)      1 (11%)     
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)                                                (10)         (9)          
      Accessory Adrenal Cortical Nodule                1 (10%)                                                                      
      Inflammation                                     1 (10%)                                                                      
   Thyroid Gland                                      (10)                                                (10)         (9)          
      Ultimobranchial Cyst                                                                                 2 (20%)                  
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 88138-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                    BENZOPHENONE                                       Date: 10/25/04    
Route: DOSED FEED                                                                                                 Time: 13:28:04    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0%           0.125%       0.25%        0.5%         1.0%         2.0%            
____________________________________________________________________________________________________________________________________
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Clitoral Gland                                     (10)                                                (10)         (9)          
      Inflammation, Chronic Active                     4 (40%)                                             4 (40%)                  
   Ovary                                              (10)         (2)          (1)                       (10)         (9)          
      Periovarian Tissue, Cyst                         3 (30%)      2 (100%)     1 (100%)                                           
      Periovarian Tissue, Inflammation, Chronic                                                                                     
        Active                                                                                                          1 (11%)     
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                              2 (20%)     10 (100%)    
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)         (1)                       (5)          (10)         (9)          
      Inflammation, Chronic Active                                  1 (100%)                  5 (100%)     3 (30%)      6 (67%)     
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 88138-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                    BENZOPHENONE                                       Date: 10/25/04    
Route: DOSED FEED                                                                                                 Time: 13:28:04    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0%           0.125%       0.25%        0.5%         1.0%         2.0%            
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (9)          
      Inflammation, Chronic Active                     2 (20%)      2 (20%)                                                         
      Mineralization                                  10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)     9 (100%)    
      Papilla, Necrosis                                                                                                 3 (33%)     
      Pelvis, Inflammation, Suppurative                                                                    1 (10%)                  
      Renal Tubule, Casts Protein                                                2 (20%)                   4 (40%)                  
      Renal Tubule, Dilatation                                                                             3 (30%)      5 (56%)     
      Renal Tubule, Regeneration                       3 (30%)      8 (80%)      6 (60%)      6 (60%)      9 (90%)      7 (78%)     
   Urinary Bladder                                    (10)                                                (10)         (9)          
      Transitional Epithelium, Hyperplasia                                                                 1 (10%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 88138-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                    BENZOPHENONE                                       Date: 10/25/04    
Route: DOSED FEED                                                                                                 Time: 13:28:04    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0%           0.125%       0.25%        0.5%         1.0%         2.0%            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                                                                                 10           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10                        
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Esophagus                                          (10)                                                (10)         (10)         
      Epithelium, Hyperkeratosis                                                                                        1 (10%)     
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cyst                                                                                                              1 (10%)     
      Hematopoietic Cell Proliferation                                                                     1 (10%)                  
      Hepatodiaphragmatic Nodule                       1 (10%)      2 (20%)      3 (30%)      2 (20%)      1 (10%)      1 (10%)     
      Inflammation, Chronic Active                                                                         1 (10%)                  
      Necrosis                                                                                1 (10%)                               
      Bile Duct, Hyperplasia                                                                                            9 (90%)     
      Bile Duct, Inflammation, Chronic Active                       1 (10%)                                                         
      Hepatocyte, Hypertrophy                                                                              5 (50%)      7 (70%)     
      Hepatocyte, Vacuolization Cytoplasmic            1 (10%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
   Stomach, Glandular                                 (10)                                                (10)         (10)         
      Epithelium, Erosion                                                                                  1 (10%)                  
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)                                                (10)         (10)         
      Myocardium, Inflammation, Chronic Active         6 (60%)                                             3 (30%)                  
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)                                   (3)          (10)         (10)         
      Accessory Adrenal Cortical Nodule                                                                    1 (10%)                  
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 88138-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                    BENZOPHENONE                                       Date: 10/25/04    
Route: DOSED FEED                                                                                                 Time: 13:28:04    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0%           0.125%       0.25%        0.5%         1.0%         2.0%            
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Preputial Gland                                    (10)                                                (10)         (10)         
      Inflammation, Chronic Active                     2 (20%)                                             6 (60%)      4 (40%)     
      Inflammation, Granulomatous                      1 (10%)                                                                      
   Prostate                                           (10)                                                (10)         (9)          
      Inflammation, Chronic Active                                                                         1 (10%)      1 (11%)     
   Seminal Vesicle                                    (10)                                                (10)         (9)          
      Atrophy                                                                                                           3 (33%)     
   Testes                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Mineralization                                                                                       1 (10%)                  
      Germinal Epithelium, Degeneration                                                                                10 (100%)    
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                                                                                          10 (100%)    
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)                      (2)          (3)          (10)         (10)         
      Inflammation, Chronic Active                     1 (10%)                   2 (100%)     3 (100%)     1 (10%)      5 (50%)     
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 88138-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                    BENZOPHENONE                                       Date: 10/25/04    
Route: DOSED FEED                                                                                                 Time: 13:28:04    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0%           0.125%       0.25%        0.5%         1.0%         2.0%            
____________________________________________________________________________________________________________________________________
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic Active                                  2 (20%)      3 (30%)      4 (40%)      2 (20%)                  
      Mineralization                                                                          5 (50%)     10 (100%)                 
      Papilla, Necrosis                                                                                    2 (20%)      6 (60%)     
      Renal Tubule, Accumulation, Hyaline Droplet                   1 (10%)                                                         
      Renal Tubule, Casts Protein                                   8 (80%)      8 (80%)      9 (90%)     10 (100%)                 
      Renal Tubule, Dilatation                                                   6 (60%)      8 (80%)      9 (90%)      8 (80%)     
      Renal Tubule, Regeneration                      10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)     8 (80%)     
      Renal Tubule, Vacuolization Cytoplasmic                                    1 (10%)                                            
   Ureter                                                                                                              (2)          
      Transitional Epithelium, Necrosis                                                                                 2 (100%)    
   Urinary Bladder                                    (10)                                                (10)         (9)          
      Transitional Epithelium, Hyperplasia                                                                 1 (10%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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