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TDMS Study 88138-01 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 10/25/04       
EXPERIMENT: 88138 TEST: 01                                                                                     TIME: 13:30:25       
TEST TYPE:  SUBCHRON 90-DAY                                                                                    PAGE:       1        
CONT: NO1-ES-15320                              ROUTE: DOSED FEED                                              NTP C#: C88138       
PATHOLOGIST: YARRINGTON, J.                  YARRINGTON, JOHN                                                  CAS: 119-61-9        
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 10/25/04       
EXPERIMENT: 88138 TEST: 01                                                                                     TIME: 13:30:25       
TEST TYPE:  SUBCHRON 90-DAY                                                                                                         
CONT: NO1-ES-15320                              ROUTE: DOSED FEED                                              NTP C#: C88138       
PATHOLOGIST: YARRINGTON, J.                  YARRINGTON, JOHN                                                  CAS: 119-61-9        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                      BENZOPHENONE                                                                                
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Bone Marrow                            Atrophy                                                                                      
Heart: Myocardium                      Inflammation Chronic                                                                         
Kidney                                 Inflammation Chronic                                                                         
                                       Mineralization                                                                               
Kidney: Papilla                        Necrosis                                                                                     
Kidney: Renal Tubule                   Casts Protein                                                                                
                                       Dilatation                                                                                   
                                       Regeneration                                                                                 
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Hepatocyte                      Hypertrophy                                                                                  
                                       Vacuolization Cytoplasmic                                                                    
Lung                                   Inflammation Chronic                                                                         
Preputial Gland                        Inflammation Chronic                                                                         
Seminal Vesicle                        Atrophy                                                                                      
Testes: Germinal Epithelium            Degeneration                                                                                 
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Bone Marrow                            Atrophy                                                                                      
Clitoral Gland                         Inflammation Chronic                                                                         
Kidney: Papilla                        Necrosis                                                                                     
Kidney: Renal Tubule                   Casts Protein                                                                                
                                       Dilatation                                                                                   
                                       Regeneration                                                                                 
Liver                                  Inflammation Chronic                                                                         
                                       Inflammation Granulomatous                                                                   
Liver: Hepatocyte                      Hypertrophy                                                                                  
                                       Vacuolization Cytoplasmic                                                                    
Lung                                   Inflammation Chronic                                                                         
Ovary: Periovarian Tissue              Cyst                                                                                         
===============================================================                                                                     
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                       BENZOPHENONE                    
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/10.00          10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001N**      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001N**      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001N**      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          2/10.00          10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             20.0%            100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           12              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.234          P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.227          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.227          P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.227          P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.234          (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.237          P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/10 (40%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         4/10 (40%)       0/9 (0%)        | 
|POLY-3 RATE (b)    |        4/10.00          0/0.00           0/0.00           0/0.00           4/10.00          0/0.69          | 
|POLY-3 PERCENT (g) |        40.0%            0.0%             0.0%             0.0%             40.0%            0.0%            | 
|TERMINAL (d)       |        4/10 (40%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         4/10 (40%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.672          P=1.000N         P=1.000          P=1.000          P=0.672          P=1.000N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.667          P=0.591N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.667          P=0.376N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.667          P=0.665N        | 
|LOGISTIC REGRESSION|        P=0.672          (e)              (e)              (e)              P=0.672          (e)             | 
|COCH-ARM / FISHERS |        P=0.049N*        P=1.000          P=1.000          P=1.000          P=0.675N         P=0.054N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/10 (60%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        6/10.00          0/0.00           0/0.00           0/0.00           3/10.00          0/0.82          | 
|POLY-3 PERCENT (g) |        60.0%            0.0%             0.0%             0.0%             30.0%            0.0%            | 
|TERMINAL (d)       |        6/10 (60%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.190N         P=1.000N         P=1.000N         P=1.000N         P=0.190N         P=1.000N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.186N         P=0.517N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.186N         P=0.185N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.186N         P=0.656N        | 
|LOGISTIC REGRESSION|        P=0.190N         (e)              (e)              (e)              P=0.190N         (e)             | 
|COCH-ARM / FISHERS |        P=0.004N**       P=1.000          P=1.000          P=1.000          P=0.185N         P=0.005N**      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)       1/9 (11%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           1/10.00          1/1.61          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             10.0%            62.1%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           39              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.050          (e)              (e)              (e)              P=0.500          P=0.479         | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.500          P=0.256         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.500          P=0.310         | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.500          P=0.238         | 
|LOGISTIC REGRESSION|        P=0.500          (e)              (e)              (e)              P=0.500          (e)             | 
|COCH-ARM / FISHERS |        P=0.303          (e)              (e)              (e)              P=0.500          P=0.474         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        2/10 (20%)       3/10 (30%)       4/10 (40%)       2/10 (20%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          2/10.00          3/10.00          4/10.00          2/10.00          0/0.82          | 
|POLY-3 PERCENT (g) |        0.0%             20.0%            30.0%            40.0%            20.0%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        2/10 (20%)       3/10 (30%)       4/10 (40%)       2/10 (20%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              92 (T)           92 (T)           92 (T)           92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.360          P=0.234          P=0.111          P=0.051          P=0.234          (e)             | 
|POLY 3             |        P=0.265          P=0.227          P=0.095          P=0.033 *        P=0.227          (e)             | 
|POLY 1.5           |        P=0.379          P=0.227          P=0.095          P=0.033 *        P=0.227          (e)             | 
|POLY 6             |        P=0.254          P=0.227          P=0.095          P=0.033 *        P=0.227          (e)             | 
|LOGISTIC REGRESSION|        (e)              P=0.234          P=0.111          P=0.051          P=0.234          (e)             | 
|COCH-ARM / FISHERS |        P=0.218N         P=0.237          P=0.105          P=0.043 *        P=0.237          (e)             | 
|ORDER RESTRICTED   |        P=0.732          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       2/10 (20%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)        | 
|POLY-3 RATE (b)    |        2/10.00          2/10.00          0/10.00          0/10.00          0/10.00          0/0.69          | 
|POLY-3 PERCENT (g) |        20.0%            20.0%            0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        2/10 (20%)       2/10 (20%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.137N         P=0.707          P=0.234N         P=0.234N         P=0.234N         P=1.000N        | 
|POLY 3             |        P=0.052N         P=0.702          P=0.227N         P=0.227N         P=0.227N         P=0.667N        | 
|POLY 1.5           |        P=0.059N         P=0.702          P=0.227N         P=0.227N         P=0.227N         P=0.553N        | 
|POLY 6             |        P=0.052N         P=0.702          P=0.227N         P=0.227N         P=0.227N         P=0.704N        | 
|LOGISTIC REGRESSION|        P=0.137N         P=0.707          (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.089N         P=0.709N         P=0.237N         P=0.237N         P=0.237N         P=0.263N        | 
|ORDER RESTRICTED   |        P=0.745N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        5/10 (50%)       10/10 (100%)     0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          5/10.00          10/10.00         0/0.82          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             50.0%            100.0%           0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        5/10 (50%)       10/10 (100%)     0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              92 (T)           92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.022 *        P<0.001 **       (e)             | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.008 **       P<0.001 **       (e)             | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.008 **       P<0.001 **       (e)             | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.008 **       P<0.001 **       (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.022 *        P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P=0.158          (e)              (e)              P=0.016 *        P<0.001 **       (e)             | 
|ORDER RESTRICTED   |        P=0.233          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     9/9 (100%)      | 
|POLY-3 RATE (b)    |        10/10.00         10/10.00         10/10.00         10/10.00         10/10.00         9/9.00          | 
|POLY-3 PERCENT (g) |        100.0%           100.0%           100.0%           100.0%           100.0%           100.0%          | 
|TERMINAL (d)       |        10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           39              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Papilla                                                                                                                  | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       6/10 (60%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          2/10.00          6/6.33          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             20.0%            94.8%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.234          P=0.009 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.227          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.227          P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.227          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.063          (e)              (e)              (e)              P=0.234          (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.237          P=0.005 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Papilla                                                                                                                  | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/9 (33%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/10.00          3/3.46          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             86.8%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              39              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.093         | 
|POLY 3             |        P=0.003 **       (e)              (e)              (e)              (e)              P=0.004 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.010 *       | 
|POLY 6             |        P=0.006 **       (e)              (e)              (e)              (e)              P=0.002 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.087         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Casts Protein                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        8/10 (80%)       8/10 (80%)       9/10 (90%)       10/10 (100%)     0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          8/10.00          8/10.00          9/10.00          10/10.00         0/0.82          | 
|POLY-3 PERCENT (g) |        0.0%             80.0%            80.0%            90.0%            100.0%           0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        8/10 (80%)       8/10 (80%)       9/10 (90%)       10/10 (100%)     0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              92 (T)           92 (T)           92 (T)           92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       (e)             | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       (e)             | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       (e)             | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       (e)             | 
|LOGISTIC REGRESSION|        (e)              P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P=0.039N*        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       (e)             | 
|ORDER RESTRICTED   |        P=0.347          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Casts Protein                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        2/10 (20%)       0/10 (0%)        4/10 (40%)       0/9 (0%)        | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          2/10.00          0/10.00          4/10.00          0/0.69          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             20.0%            0.0%             40.0%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        2/10 (20%)       0/10 (0%)        4/10 (40%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              92 (T)           ---              92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.016 *        (e)              P=0.234          (e)              P=0.051          (e)             | 
|POLY 3             |        P=0.002 **       (e)              P=0.227          (e)              P=0.033 *        (e)             | 
|POLY 1.5           |        P=0.008 **       (e)              P=0.227          (e)              P=0.033 *        (e)             | 
|POLY 6             |        P=0.002 **       (e)              P=0.227          (e)              P=0.033 *        (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.234          (e)              P=0.051          (e)             | 
|COCH-ARM / FISHERS |        P=0.433          (e)              P=0.237          (e)              P=0.043 *        (e)             | 
|ORDER RESTRICTED   |        P=0.679          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        6/10 (60%)       8/10 (80%)       9/10 (90%)       8/10 (80%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          6/10.00          8/10.00          9/10.00          8/8.16          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             60.0%            80.0%            90.0%            98.0%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        6/10 (60%)       8/10 (80%)       9/10 (90%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              92 (T)           92 (T)           92 (T)           40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.009 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.009 **       P<0.001 **       P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.005 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       5/9 (56%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          3/10.00          5/5.31          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             30.0%            94.3%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           39              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.111          P=0.015 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.095          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.095          P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.095          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.010 *        (e)              (e)              (e)              P=0.111          (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.105          P=0.011 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Regeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     8/10 (80%)      | 
|POLY-3 RATE (b)    |        10/10.00         10/10.00         10/10.00         10/10.00         10/10.00         8/8.16          | 
|POLY-3 PERCENT (g) |        100.0%           100.0%           100.0%           100.0%           100.0%           98.0%           | 
|TERMINAL (d)       |        10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        P=0.995N         (e)              (e)              (e)              (e)              P=1.000N        | 
|POLY 1.5           |        P=0.111N         (e)              (e)              (e)              (e)              P=0.823N        | 
|POLY 6             |        P=1.000N         (e)              (e)              (e)              (e)              P=1.000N        | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.010N*        (e)              (e)              (e)              (e)              P=0.237N        | 
|ORDER RESTRICTED   |        P=0.004N**       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Regeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       8/10 (80%)       6/10 (60%)       6/10 (60%)       9/10 (90%)       7/9 (78%)       | 
|POLY-3 RATE (b)    |        3/10.00          8/10.00          6/10.00          6/10.00          9/10.00          7/7.15          | 
|POLY-3 PERCENT (g) |        30.0%            80.0%            60.0%            60.0%            90.0%            97.9%           | 
|TERMINAL (d)       |        3/10 (30%)       8/10 (80%)       6/10 (60%)       6/10 (60%)       9/10 (90%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           39              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.040 *        P=0.190          P=0.190          P=0.013 *        P=0.002 **      | 
|POLY 3             |        P=0.004 **       P=0.024 *        P=0.186          P=0.186          P=0.003 **       P=0.002 **      | 
|POLY 1.5           |        P=0.008 **       P=0.024 *        P=0.186          P=0.186          P=0.003 **       P=0.005 **      | 
|POLY 6             |        P=0.003 **       P=0.024 *        P=0.186          P=0.186          P=0.003 **       P=0.002 **      | 
|LOGISTIC REGRESSION|        P=0.048 *        P=0.040 *        P=0.190          P=0.190          P=0.013 *        (e)             | 
|COCH-ARM / FISHERS |        P=0.064          P=0.035 *        P=0.185          P=0.185          P=0.010 *        P=0.051         | 
|ORDER RESTRICTED   |        P=0.002 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       2/10 (20%)       3/10 (30%)       2/10 (20%)       1/10 (10%)       1/10 (10%)      | 
|POLY-3 RATE (b)    |        1/10.00          2/10.00          3/10.00          2/10.00          1/10.00          1/1.74          | 
|POLY-3 PERCENT (g) |        10.0%            20.0%            30.0%            20.0%            10.0%            57.5%           | 
|TERMINAL (d)       |        1/10 (10%)       2/10 (20%)       3/10 (30%)       2/10 (20%)       1/10 (10%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.343          P=0.500          P=0.293          P=0.500          P=0.766          P=0.500         | 
|POLY 3             |        P=0.527N         P=0.500          P=0.292          P=0.500          P=0.760          P=0.400         | 
|POLY 1.5           |        P=0.526N         P=0.500          P=0.292          P=0.500          P=0.760          P=0.515         | 
|POLY 6             |        P=0.506N         P=0.500          P=0.292          P=0.500          P=0.760          P=0.355         | 
|LOGISTIC REGRESSION|        P=0.552N         P=0.500          P=0.293          P=0.500          P=0.766          (e)             | 
|COCH-ARM / FISHERS |        P=0.314N         P=0.500          P=0.291          P=0.500          P=0.763N         P=0.763N        | 
|ORDER RESTRICTED   |        P=0.453          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       4/10 (40%)       2/10 (20%)       3/10 (30%)       1/10 (10%)       2/9 (22%)       | 
|POLY-3 RATE (b)    |        1/10.00          4/10.00          2/10.00          3/10.00          1/10.00          2/2.53          | 
|POLY-3 PERCENT (g) |        10.0%            40.0%            20.0%            30.0%            10.0%            79.0%           | 
|TERMINAL (d)       |        1/10 (10%)       4/10 (40%)       2/10 (20%)       3/10 (30%)       1/10 (10%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           39              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.123          P=0.157          P=0.500          P=0.293          P=0.766          P=0.210         | 
|POLY 3             |        P=0.577          P=0.148          P=0.500          P=0.292          P=0.760          P=0.137         | 
|POLY 1.5           |        P=0.529          P=0.148          P=0.500          P=0.292          P=0.760          P=0.207         | 
|POLY 6             |        P=0.568N         P=0.148          P=0.500          P=0.292          P=0.760          P=0.115         | 
|LOGISTIC REGRESSION|        P=0.452N         P=0.157          P=0.500          P=0.293          P=0.766          (e)             | 
|COCH-ARM / FISHERS |        P=0.482N         P=0.152          P=0.500          P=0.291          P=0.763N         P=0.458         | 
|ORDER RESTRICTED   |        P=0.157          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          1/10.00          0/0.82          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             10.0%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.362          (e)              (e)              (e)              P=0.500          (e)             | 
|POLY 3             |        P=0.127          (e)              (e)              (e)              P=0.500          (e)             | 
|POLY 1.5           |        P=0.175          (e)              (e)              (e)              P=0.500          (e)             | 
|POLY 6             |        P=0.123          (e)              (e)              (e)              P=0.500          (e)             | 
|LOGISTIC REGRESSION|        P=0.360          (e)              (e)              (e)              P=0.500          (e)             | 
|COCH-ARM / FISHERS |        P=0.585          (e)              (e)              (e)              P=0.500          (e)             | 
|ORDER RESTRICTED   |        P=0.741          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)        | 
|POLY-3 RATE (b)    |        3/10.00          0/10.00          0/10.00          0/10.00          0/10.00          0/0.69          | 
|POLY-3 PERCENT (g) |        30.0%            0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        3/10 (30%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.149N         P=0.111N         P=0.111N         P=0.111N         P=0.111N         P=1.000N        | 
|POLY 3             |        P=0.040N*        P=0.095N         P=0.095N         P=0.095N         P=0.095N         P=0.622N        | 
|POLY 1.5           |        P=0.048N*        P=0.095N         P=0.095N         P=0.095N         P=0.095N         P=0.456N        | 
|POLY 6             |        P=0.039N*        P=0.095N         P=0.095N         P=0.095N         P=0.095N         P=0.678N        | 
|LOGISTIC REGRESSION|        P=0.149N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.113N         P=0.105N         P=0.105N         P=0.105N         P=0.105N         P=0.124N        | 
|ORDER RESTRICTED   |        P=0.661N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/10.00          0/0.82          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       4/10 (40%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)        | 
|POLY-3 RATE (b)    |        2/10.00          4/10.00          0/10.00          0/10.00          0/10.00          0/0.69          | 
|POLY-3 PERCENT (g) |        20.0%            40.0%            0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        2/10 (20%)       4/10 (40%)       0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.064N         P=0.317          P=0.234N         P=0.234N         P=0.234N         P=1.000N        | 
|POLY 3             |        P=0.015N*        P=0.318          P=0.227N         P=0.227N         P=0.227N         P=0.667N        | 
|POLY 1.5           |        P=0.018N*        P=0.318          P=0.227N         P=0.227N         P=0.227N         P=0.553N        | 
|POLY 6             |        P=0.014N*        P=0.318          P=0.227N         P=0.227N         P=0.227N         P=0.704N        | 
|LOGISTIC REGRESSION|        P=0.064N         P=0.317          (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.039N*        P=0.314          P=0.237N         P=0.237N         P=0.237N         P=0.263N        | 
|ORDER RESTRICTED   |        P=0.711N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        9/10 (90%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/10.00          9/9.08          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.1%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)        | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/10.00          0/0.69          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        5/10 (50%)       7/10 (70%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          5/10.00          7/7.25          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             50.0%            96.6%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        5/10 (50%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.022 *        P=0.003 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.008 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.008 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.008 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P=0.022 *        (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.016 *        P=0.002 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        2/10 (20%)       8/10 (80%)       10/10 (100%)     10/10 (100%)     7/9 (78%)       | 
|POLY-3 RATE (b)    |        0/10.00          2/10.00          8/10.00          10/10.00         10/10.00         7/7.15          | 
|POLY-3 PERCENT (g) |        0.0%             20.0%            80.0%            100.0%           100.0%           97.9%           | 
|TERMINAL (d)       |        0/10 (0%)        2/10 (20%)       8/10 (80%)       10/10 (100%)     10/10 (100%)     0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              92 (T)           92 (T)           92 (T)           92 (T)           39              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.234          P<0.001 **       P<0.001 **       P<0.001 **       P=0.002 **      | 
|POLY 3             |        P<0.001 **       P=0.227          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.227          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.227          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.234          P<0.001 **       P<0.001 **       P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.237          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)    | 
|POLY-3 RATE (b)    |        1/10.00          10/10.00         10/10.00         10/10.00         10/10.00         10/10.00        | 
|POLY-3 PERCENT (g) |        10.0%            100.0%           100.0%           100.0%           100.0%           100.0%          | 
|TERMINAL (d)       |        1/10 (10%)       10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P=0.003 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        9/10 (90%)       10/10 (100%)     7/9 (78%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          9/10.00          10/10.00         7/7.15          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             90.0%            100.0%           97.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        9/10 (90%)       10/10 (100%)     0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              92 (T)           92 (T)           39              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       P=0.002 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       0/0 (0%)         2/2 (100%)       3/3 (100%)       1/10 (10%)       5/10 (50%)      | 
|POLY-3 RATE (b)    |        1/10.00          0/0.00           2/2.00           3/3.00           1/10.00          5/5.41          | 
|POLY-3 PERCENT (g) |        10.0%            0.0%             100.0%           100.0%           10.0%            92.4%           | 
|TERMINAL (d)       |        1/10 (10%)       0/0 (0%)         2/2 (100%)       3/3 (100%)       1/10 (10%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           ---              92 (T)           92 (T)           92 (T)           40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=1.000N         P=0.043 *        P=0.015 *        P=0.766          P=0.022 *       | 
|POLY 3             |        (e)              (e)              P=0.005 **       P<0.001 **       P=0.760          P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              P=0.005 **       P<0.001 **       P=0.760          P=0.004 **      | 
|POLY 6             |        (e)              (e)              P=0.005 **       P<0.001 **       P=0.760          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.555N         (e)              P=0.043 *        P=0.015 *        P=0.766          (e)             | 
|COCH-ARM / FISHERS |        P=0.244          P=1.000          P=0.045 *        P=0.014 *        P=0.763N         P=0.070         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        1/1 (100%)       0/0 (0%)         5/5 (100%)       3/10 (30%)       6/9 (67%)       | 
|POLY-3 RATE (b)    |        0/10.00          1/1.00           0/0.00           5/5.00           3/10.00          6/6.23          | 
|POLY-3 PERCENT (g) |        0.0%             100.0%           0.0%             100.0%           30.0%            96.3%           | 
|TERMINAL (d)       |        0/10 (0%)        1/1 (100%)       0/0 (0%)         5/5 (100%)       3/10 (30%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              92 (T)           ---              92 (T)           92 (T)           39              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.077          (e)              P<0.001 **       P=0.111          P=0.005 **      | 
|POLY 3             |        (e)              P=0.091          (e)              P<0.001N**       P=0.095          P<0.001 **      | 
|POLY 1.5           |        (e)              P=0.091          (e)              P<0.001N**       P=0.095          P<0.001 **      | 
|POLY 6             |        (e)              P=0.091          (e)              P<0.001N**       P=0.095          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.242          P=0.077          (e)              P<0.001 **       P=0.111          (e)             | 
|COCH-ARM / FISHERS |        P=0.037 *        P=0.091          (e)              P<0.001 **       P=0.105          P=0.003 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary: Periovarian Tissue                                                                                                        | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary: Periovarian Tissue                                                                                                        | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       2/2 (100%)       1/1 (100%)       0/0 (0%)         0/10 (0%)        0/9 (0%)        | 
|POLY-3 RATE (b)    |        3/10.00          2/2.00           1/1.00           0/0.00           0/10.00          0/0.69          | 
|POLY-3 PERCENT (g) |        30.0%            100.0%           100.0%           0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        3/10 (30%)       2/2 (100%)       1/1 (100%)       0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.046N*        P=0.158          P=0.388          P=1.000N         P=0.111N         P=1.000N        | 
|POLY 3             |        (e)              P=0.130          P=0.384          (e)              P=0.095N         P=0.622N        | 
|POLY 1.5           |        (e)              P=0.130          P=0.384          (e)              P=0.095N         P=0.456N        | 
|POLY 6             |        (e)              P=0.130          P=0.384          (e)              P=0.095N         P=0.678N        | 
|LOGISTIC REGRESSION|        P=0.046N*        P=0.158          P=0.388          (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.007N**       P=0.152          P=0.364          P=1.000          P=0.105N         P=0.124N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         6/10 (60%)       4/10 (40%)      | 
|POLY-3 RATE (b)    |        2/10.00          0/0.00           0/0.00           0/0.00           6/10.00          4/4.49          | 
|POLY-3 PERCENT (g) |        20.0%            0.0%             0.0%             0.0%             60.0%            89.0%           | 
|TERMINAL (d)       |        2/10 (20%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         6/10 (60%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              92 (T)           40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=1.000N         P=1.000N         P=1.000N         P=0.091          P=0.051         | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.077          P=0.034 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.077          P=0.077         | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.077          P=0.023 *       | 
|LOGISTIC REGRESSION|        P=0.085          (e)              (e)              (e)              P=0.091          (e)             | 
|COCH-ARM / FISHERS |        P=0.247          P=1.000          P=1.000          P=1.000          P=0.085          P=0.314         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        3/9 (33%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          3/3.49          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             85.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.093         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.004 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.011 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.002 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.025 *        (e)              (e)              (e)              (e)              P=0.087         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/10.00          10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          0/0.82          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Ultimobranchial Cyst                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)       0/9 (0%)        | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           2/10.00          0/0.69          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             20.0%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.234          (e)              (e)              (e)              P=0.234          (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.227          (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.227          (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.227          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.234          (e)             | 
|COCH-ARM / FISHERS |        P=0.652          (e)              (e)              (e)              P=0.237          (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 01                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                       BENZOPHENONE
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ureter: Transitional Epithelium                                                                                                  | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/2 (100%)      | 
|POLY-3 RATE (b)    |        0/0.00           0/0.00           0/0.00           0/0.00           0/0.00           2/2.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              40              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ureter: Transitional Epithelium                                                                                                  | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|POLY-3 RATE (b)    |        0/0.00           0/0.00           0/0.00           0/0.00           0/0.00           0/0.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).