National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/16015

TDMS Study 60855-01 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: BIORELIANCE                                      BETA-BROMO-BETA-NITROSTYRENE                             DATE: 10/19/04       
EXPERIMENT: 60855 TEST: 01                                                                                     TIME: 14:14:02       
TEST TYPE:  18-33 DAYS                                                                                         PAGE:       1        
CONT: NO1-ES-15319                              ROUTE: GAVAGE                                                  NTP C#: C60855       
PATHOLOGIST: MISSING                                                                                           CAS: 7166-19-0       
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: BIORELIANCE                                      BETA-BROMO-BETA-NITROSTYRENE                             DATE: 10/19/04       
EXPERIMENT: 60855 TEST: 01                                                                                     TIME: 14:14:02       
TEST TYPE:  18-33 DAYS                                                                                                              
CONT: NO1-ES-15319                              ROUTE: GAVAGE                                                  NTP C#: C60855       
PATHOLOGIST: MISSING                                                                                           CAS: 7166-19-0       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF              BETA-BROMO-BETA-NITROSTYRENE                                                                        
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Intestine Large, Cecum                 Inflammation                                                                                 
Lung                                   Congestion                                                                                   
                                       Hemorrhage                                                                                   
                                       Inflammation Focal                                                                           
Lymph Node, Mesenteric                 Hemorrhage                                                                                   
Nose                                   Congestion                                                                                   
                                       Inflammation                                                                                 
                                       Necrosis                                                                                     
Pancreas                               Inflammation                                                                                 
Preputial Gland                        Inflammation                                                                                 
Prostate                               Inflammation                                                                                 
Spleen: Lymphoid Follicle              Depletion Cellular                                                                           
Stomach, Forestomach                   Hemorrhage                                                                                   
                                       Inflammation                                                                                 
                                       Necrosis                                                                                     
                                       Ulcer                                                                                        
Stomach, Forestomach: Epithelium       Hyperkeratosis                                                                               
                                       Hyperplasia                                                                                  
Stomach, Glandular                     Inflammation                                                                                 
Testes                                 Degeneration                                                                                 
Thymus                                 Atrophy                                                                                      
                                       Hemorrhage                                                                                   
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Intestine Large, Cecum                 Inflammation                                                                                 
Kidney                                 Mineralization                                                                               
Liver                                  Hepatodiaphragmatic Nodule                                                                   
                                       Inflammation                                                                                 
                                       Necrosis Focal                                                                               
Lung                                   Congestion                                                                                   
                                       Hemorrhage                                                                                   
Lymph Node, Mesenteric                 Hemorrhage                                                                                   
Nose                                   Inflammation                                                                                 
                                       Necrosis                                                                                     
Nose: Respiratory Epithelium           Metaplasia                                                                                   
Pancreas                               Inflammation                                                                                 
Spleen                                 Inflammation                                                                                 
Stomach, Forestomach                   Hemorrhage                                                                                   
                                       Inflammation                                                                                 
                                       Necrosis                                                                                     
                                       Ulcer                                                                                        
Stomach, Forestomach: Epithelium       Hyperkeratosis                                                                               
                                       Hyperplasia                                                                                  
Stomach, Glandular                     Inflammation                                                                                 
Thymus                                 Atrophy                                                                                      
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: BIORELIANCE                                      BETA-BROMO-BETA-NITROSTYRENE                             DATE: 10/19/04       
EXPERIMENT: 60855 TEST: 01                                                                                     TIME: 14:14:02       
TEST TYPE:  18-33 DAYS                                                                                                              
CONT: NO1-ES-15319                              ROUTE: GAVAGE                                                  NTP C#: C60855       
PATHOLOGIST: MISSING                                                                                           CAS: 7166-19-0       
                                       Hemorrhage                                                                                   
Uterus                                 Hydrometra                                                                                   
Uterus: Bilateral                      Hydrometra                                                                                   
===============================================================                                                                     
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE            
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|INT SACRIFICE 1 (c)|                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         5/10 (50%)       1/10 (10%)      | 
|POLY-3 RATE (b)    |        3/10.00          0/0.00           0/0.00           0/0.00           5/10.00          1/1.06          | 
|POLY-3 PERCENT (g) |        30.0%            0.0%             0.0%             0.0%             50.0%            94.1%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        3/10 (30%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         4/9 (44%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           ---              ---              ---              6                6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.080          P=1.000N         P=1.000N         P=1.000N         P=0.282          P=0.455         | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.329          P=0.457         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.329          P=0.531         | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.329          P=0.449         | 
|LOGISTIC REGRESSION|        P=0.656N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.232N         P=1.000          P=1.000          P=1.000          P=0.325          P=0.291N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       0/0 (0%)         0/0 (0%)         0/2 (0%)         1/10 (10%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        3/10.00          0/0.00           0/0.00           0/0.06           1/9.11           0/0.03          | 
|POLY-3 PERCENT (g) |        30.0%            0.0%             0.0%             0.0%             11.0%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        3/10 (30%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           ---              ---              ---              29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.333N         P=1.000          P=1.000N         P=1.000          P=0.333N         P=1.000N        | 
|POLY 3             |        (e)              (e)              (e)              P=0.773N         P=0.328N         P=0.675N        | 
|POLY 1.5           |        (e)              (e)              (e)              P=0.738N         P=0.318N         P=0.639N        | 
|POLY 6             |        (e)              (e)              (e)              P=0.780N         P=0.332N         P=0.678N        | 
|LOGISTIC REGRESSION|        P=0.333N         (e)              (e)              (e)              P=0.333N         (e)             | 
|COCH-ARM / FISHERS |        P=0.056N         P=1.000          P=1.000          P=0.545N         P=0.291N         P=0.105N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        1/10.00          0/0.00           0/0.00           0/0.00           1/9.01           0/0.07          | 
|POLY-3 PERCENT (g) |        10.0%            0.0%             0.0%             0.0%             11.1%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        1/10 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           ---              ---              ---              29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.743          P=1.000N         P=1.000N         P=1.000N         P=0.743          P=1.000N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.737          P=0.759N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.739          P=0.742N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.737          P=0.760N        | 
|LOGISTIC REGRESSION|        P=0.749          (e)              (e)              (e)              P=0.749          (e)             | 
|COCH-ARM / FISHERS |        P=0.327N         P=1.000          P=1.000          P=1.000          P=0.763N         P=0.500N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        1/10 (10%)       4/10 (40%)       6/10 (60%)       9/10 (90%)       2/8 (25%)       | 
|POLY-3 RATE (b)    |        0/10.00          1/10.00          4/10.00          6/10.00          9/10.00          2/2.02          | 
|POLY-3 PERCENT (g) |        0.0%             10.0%            40.0%            60.0%            90.0%            99.2%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        1/10 (10%)       4/10 (40%)       4/8 (50%)        8/9 (89%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              29 (T)           29 (T)           9                14               6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.500          P=0.051          P=0.008 **       P<0.001 **       P=0.004 **      | 
|POLY 3             |        P<0.001 **       P=0.500          P=0.033 *        P<0.001 **       P<0.001 **       P=0.029 *       | 
|POLY 1.5           |        P<0.001 **       P=0.500          P=0.033 *        P<0.001 **       P<0.001 **       P=0.033 *       | 
|POLY 6             |        P<0.001 **       P=0.500          P=0.033 *        P<0.001 **       P<0.001 **       P=0.029 *       | 
|LOGISTIC REGRESSION|        P=0.011 *        P=0.500          P=0.051          (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.075          P=0.500          P=0.043 *        P=0.005 **       P<0.001 **       P=0.183         | 
|ORDER RESTRICTED   |        P=0.068          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        8/10 (80%)       1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          8/10.00          1/1.06          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             80.0%            94.1%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        7/9 (78%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              6                6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P=0.455         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P=0.245         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P=0.265         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P=0.243         | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.026 *        (e)              (e)              (e)              P<0.001 **       P=0.500         | 
|ORDER RESTRICTED   |        P=0.096          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/2 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.06           0/9.11           0/0.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/10 (40%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         5/10 (50%)       7/10 (70%)      | 
|POLY-3 RATE (b)    |        4/10.00          0/0.00           0/0.00           0/0.00           5/10.00          7/7.01          | 
|POLY-3 PERCENT (g) |        40.0%            0.0%             0.0%             0.0%             50.0%            99.9%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        4/10 (40%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         4/9 (44%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           ---              ---              ---              6                6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=1.000N         P=1.000N         P=1.000N         P=0.431          P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.500          P=0.012 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.500          P=0.015 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.500          P=0.012 *       | 
|LOGISTIC REGRESSION|        P=0.569          (e)              (e)              (e)              (e)              P=0.996         | 
|COCH-ARM / FISHERS |        P=0.131          P=1.000          P=1.000          P=1.000          P=0.500          P=0.185         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         1/1 (100%)       0/2 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           1/1.00           0/0.06           0/9.11           0/0.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             100.0%           0.0%             0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         1/1 (100%)       0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              29 (T)           ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.722N         (e)              P=0.077          (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              P=0.091          (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              P=0.091          (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              P=0.091          (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.077          (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.401N         (e)              P=0.091          (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        1/1 (100%)       3/3 (100%)       1/1 (100%)       0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          1/1.00           3/3.00           1/1.00           0/9.01           0/0.07          | 
|POLY-3 PERCENT (g) |        0.0%             100.0%           100.0%           100.0%           0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        1/1 (100%)       3/3 (100%)       1/1 (100%)       0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              29 (T)           29 (T)           29 (T)           ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.378N         P=0.077          P=0.003 **       P=0.077          (e)              (e)             | 
|POLY 3             |        P<0.001N**       P=0.091N         P=0.003 **       P=0.091          (e)              (e)             | 
|POLY 1.5           |        P<0.001N**       P=0.091N         P=0.003 **       P=0.091          (e)              (e)             | 
|POLY 6             |        P<0.001N**       P=0.091N         P=0.003 **       P=0.091          (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              P=0.077          P=0.003 **       P=0.077          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.057N         P=0.091          P=0.003 **       P=0.091          (e)              (e)             | 
|ORDER RESTRICTED   |        P=0.815          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/1 (0%)         0/2 (0%)         1/10 (10%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/1.00           0/0.06           1/9.11           0/0.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             11.0%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/1 (0%)         0/0 (0%)         1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.469          (e)              (e)              (e)              P=0.479          (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.481          (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.486          (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.479          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.479          (e)             | 
|COCH-ARM / FISHERS |        P=0.715          (e)              (e)              (e)              P=0.500          (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/1 (0%)         0/3 (0%)         0/1 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/1.00           0/3.00           0/1.00           0/9.01           2/2.05          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             97.4%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/1 (0%)         0/3 (0%)         0/1 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       (e)              (e)              (e)              (e)              P=0.185         | 
|POLY 3             |        P=0.210          (e)              (e)              (e)              (e)              P=0.041 *       | 
|POLY 1.5           |        P=0.149          (e)              (e)              (e)              (e)              P=0.050         | 
|POLY 6             |        P=0.218          (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        P=0.707          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.060          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/1 (0%)         0/2 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/1.00           0/0.06           0/9.11           0/0.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/1 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/1 (0%)         0/3 (0%)         0/1 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/1.00           0/3.00           0/1.00           0/9.01           2/2.05          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             97.4%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/1 (0%)         0/3 (0%)         0/1 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       (e)              (e)              (e)              (e)              P=0.185         | 
|POLY 3             |        P=0.210          (e)              (e)              (e)              (e)              P=0.041 *       | 
|POLY 1.5           |        P=0.149          (e)              (e)              (e)              (e)              P=0.050         | 
|POLY 6             |        P=0.218          (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        P=0.707          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.060          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/2 (0%)         0/10 (0%)        4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.06           0/9.11           4/4.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.2%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.024 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.043 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        3/10 (30%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           3/3.06          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.0%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.046 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.004 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.006 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.031 *        (e)              (e)              (e)              (e)              P=0.105         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       0/0 (0%)         0/0 (0%)         0/2 (0%)         2/10 (20%)       3/10 (30%)      | 
|POLY-3 RATE (b)    |        3/10.00          0/0.00           0/0.00           0/0.06           2/9.11           3/3.03          | 
|POLY-3 PERCENT (g) |        30.0%            0.0%             0.0%             0.0%             22.0%            99.1%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        3/10 (30%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         2/9 (22%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           ---              ---              ---              29 (T)           2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       P=1.000          P=1.000N         P=1.000N         P=0.553N         P=0.036 *       | 
|POLY 3             |        (e)              (e)              (e)              P=0.773N         P=0.546N         P=0.131         | 
|POLY 1.5           |        (e)              (e)              (e)              P=0.738N         P=0.534N         P=0.156         | 
|POLY 6             |        (e)              (e)              (e)              P=0.780N         P=0.551N         P=0.129         | 
|LOGISTIC REGRESSION|        P=0.593          (e)              (e)              (e)              P=0.553N         (e)             | 
|COCH-ARM / FISHERS |        P=0.551          P=1.000          P=1.000          P=0.545N         P=0.500N         P=0.686N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)       1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           2/9.01           1/1.06          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             22.2%            94.1%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         2/9 (22%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.019 *        (e)              (e)              (e)              P=0.210          P=0.455         | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.202          P=0.245         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.204          P=0.265         | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.202          P=0.243         | 
|LOGISTIC REGRESSION|        P=0.172          (e)              (e)              (e)              P=0.204          (e)             | 
|COCH-ARM / FISHERS |        P=0.355          (e)              (e)              (e)              P=0.237          P=0.500         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       0/0 (0%)         0/0 (0%)         0/2 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        3/10.00          0/0.00           0/0.00           0/0.06           0/9.11           0/0.03          | 
|POLY-3 PERCENT (g) |        30.0%            0.0%             0.0%             0.0%             0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        3/10 (30%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.129N         P=1.000          P=1.000N         P=1.000N         P=0.129N         P=1.000N        | 
|POLY 3             |        (e)              (e)              (e)              P=0.773N         P=0.113N         P=0.675N        | 
|POLY 1.5           |        (e)              (e)              (e)              P=0.738N         P=0.108N         P=0.639N        | 
|POLY 6             |        (e)              (e)              (e)              P=0.780N         P=0.115N         P=0.678N        | 
|LOGISTIC REGRESSION|        P=0.129N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.034N*        P=1.000          P=1.000          P=0.545N         P=0.105N         P=0.105N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           0/0.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         1/2 (50%)        1/10 (10%)       0/9 (0%)        | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           1/1.03           1/9.11           0/0.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             97.1%            11.0%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              9                29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.393          (e)              (e)              P=0.500          P=0.479          (e)             | 
|POLY 3             |        (e)              (e)              (e)              P=0.065          P=0.481          (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              P=0.072          P=0.486          (e)             | 
|POLY 6             |        (e)              (e)              (e)              P=0.063          P=0.479          (e)             | 
|LOGISTIC REGRESSION|        P=0.522N         (e)              (e)              (e)              P=0.479          (e)             | 
|COCH-ARM / FISHERS |        P=0.547N         (e)              (e)              P=0.167          P=0.500          (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         2/9 (22%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           2/9.00           0/0.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             22.2%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         2/9 (22%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.210          (e)              (e)              (e)              P=0.210          (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.201          (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.201          (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.201          (e)             | 
|LOGISTIC REGRESSION|        P=0.204          (e)              (e)              (e)              P=0.210          (e)             | 
|COCH-ARM / FISHERS |        P=0.670          (e)              (e)              (e)              P=0.211          (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/2 (0%)         2/10 (20%)       0/9 (0%)        | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.06           2/10.00          0/0.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             20.0%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              14               ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.143          (e)              (e)              (e)              P=0.228          (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.227          (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.227          (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.227          (e)             | 
|LOGISTIC REGRESSION|        P=0.616          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.634          (e)              (e)              (e)              P=0.237          (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/9 (11%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           1/9.00           0/0.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             11.1%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.479          (e)              (e)              (e)              P=0.479          (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.479          (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.479          (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.479          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.479          (e)             | 
|COCH-ARM / FISHERS |        P=0.730          (e)              (e)              (e)              P=0.474          (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/2 (0%)         2/10 (20%)       4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.06           2/9.11           4/4.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             22.0%            100.0%          | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         2/9 (22%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           5               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.210          P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.204          P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.210          P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.202          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.035 *        (e)              (e)              (e)              P=0.210          P=0.861         | 
|COCH-ARM / FISHERS |        P=0.018 *        (e)              (e)              (e)              P=0.237          P=0.043 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)       7/10 (70%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           1/9.01           7/7.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             11.1%            99.9%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.479          P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.479          P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.481          P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.479          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.082          (e)              (e)              (e)              P=0.479          P=0.995         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.002 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/8.06           0/9.11           2/2.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.4%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/8 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.004 **       (e)              (e)              (e)              (e)              P=0.162         | 
|POLY 3             |        P=0.154          (e)              (e)              (e)              (e)              P=0.041 *       | 
|POLY 1.5           |        P=0.109          (e)              (e)              (e)              (e)              P=0.047 *       | 
|POLY 6             |        P=0.156          (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.010 *        (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/9.01           0/0.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       1/10 (10%)       2/10 (20%)       6/10 (60%)       2/10 (20%)       4/10 (40%)      | 
|POLY-3 RATE (b)    |        2/10.00          1/10.00          2/10.00          6/10.00          2/10.00          4/4.03          | 
|POLY-3 PERCENT (g) |        20.0%            10.0%            20.0%            60.0%            20.0%            99.3%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        2/10 (20%)       1/10 (10%)       2/10 (20%)       4/8 (50%)        1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           29 (T)           29 (T)           9                14               2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.500N         P=0.707          P=0.069          P=0.670          P=0.014 *       | 
|POLY 3             |        P=0.038 *        P=0.500N         P=0.702          P=0.077          P=0.702          P=0.022 *       | 
|POLY 1.5           |        P=0.038 *        P=0.500N         P=0.702          P=0.077          P=0.702          P=0.029 *       | 
|POLY 6             |        P=0.038 *        P=0.500N         P=0.702          P=0.077          P=0.702          P=0.022 *       | 
|LOGISTIC REGRESSION|        P=0.207N         P=0.500N         P=0.707          (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.185          P=0.500N         P=0.709N         P=0.085          P=0.709N         P=0.314         | 
|ORDER RESTRICTED   |        P=0.011 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       3/10 (30%)       4/10 (40%)       6/10 (60%)       3/10 (30%)       1/10 (10%)      | 
|POLY-3 RATE (b)    |        1/10.00          3/10.00          4/10.00          6/10.00          3/10.00          1/1.06          | 
|POLY-3 PERCENT (g) |        10.0%            30.0%            40.0%            60.0%            30.0%            94.1%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        1/10 (10%)       3/10 (30%)       4/10 (40%)       6/10 (60%)       2/9 (22%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           29 (T)           29 (T)           29 (T)           6                6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.099          P=0.293          P=0.157          P=0.034 *        P=0.272          P=0.455         | 
|POLY 3             |        P=0.221          P=0.292          P=0.148          P=0.018 *        P=0.292          P=0.356         | 
|POLY 1.5           |        P=0.227          P=0.292          P=0.148          P=0.018 *        P=0.292          P=0.397         | 
|POLY 6             |        P=0.221          P=0.292          P=0.148          P=0.018 *        P=0.292          P=0.352         | 
|LOGISTIC REGRESSION|        P=0.616N         P=0.293          P=0.157          P=0.034 *        (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.236N         P=0.291          P=0.152          P=0.029 *        P=0.291          P=0.763N        | 
|ORDER RESTRICTED   |        P=0.475          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/8.06           1/10.00          2/2.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             10.0%            98.4%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/8 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              14               2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.162         | 
|POLY 3             |        P=0.035 *        (e)              (e)              (e)              P=0.500          P=0.041 *       | 
|POLY 1.5           |        P=0.025 *        (e)              (e)              (e)              P=0.500          P=0.047 *       | 
|POLY 6             |        P=0.036 *        (e)              (e)              (e)              P=0.500          P=0.040 *       | 
|LOGISTIC REGRESSION|        P=0.729N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.013 *        (e)              (e)              (e)              P=0.500          P=0.237         | 
|ORDER RESTRICTED   |        P=0.002 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          2/10.00          0/0.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             20.0%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              6                ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.232          (e)              (e)              (e)              P=0.228          (e)             | 
|POLY 3             |        P=0.010 *        (e)              (e)              (e)              P=0.227          (e)             | 
|POLY 1.5           |        P=0.011 *        (e)              (e)              (e)              P=0.227          (e)             | 
|POLY 6             |        P=0.010 *        (e)              (e)              (e)              P=0.227          (e)             | 
|LOGISTIC REGRESSION|        P=0.739N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.413          (e)              (e)              (e)              P=0.237          (e)             | 
|ORDER RESTRICTED   |        P=0.820          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        2/10 (20%)       2/10 (20%)       1/10 (10%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          2/10.00          2/10.00          1/9.11           0/0.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             20.0%            20.0%            11.0%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        2/10 (20%)       0/8 (0%)         1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              29 (T)           9                29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.393          (e)              P=0.234          P=0.237          P=0.479          (e)             | 
|POLY 3             |        P=0.241          (e)              P=0.227          P=0.227          P=0.481          (e)             | 
|POLY 1.5           |        P=0.256          (e)              P=0.227          P=0.227          P=0.486          (e)             | 
|POLY 6             |        P=0.235          (e)              P=0.227          P=0.227          P=0.479          (e)             | 
|LOGISTIC REGRESSION|        P=0.095N         (e)              P=0.234          (e)              P=0.479          (e)             | 
|COCH-ARM / FISHERS |        P=0.438N         (e)              P=0.237          P=0.237          P=0.500          (e)             | 
|ORDER RESTRICTED   |        P=0.828          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        3/10 (30%)       0/10 (0%)        0/10 (0%)        2/10 (20%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          3/10.00          0/10.00          0/10.00          2/9.01           0/0.07          | 
|POLY-3 PERCENT (g) |        0.0%             30.0%            0.0%             0.0%             22.2%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        3/10 (30%)       0/10 (0%)        0/10 (0%)        2/9 (22%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              29 (T)           ---              ---              29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.467          P=0.111          (e)              (e)              P=0.210          (e)             | 
|POLY 3             |        P=0.328          P=0.095          (e)              (e)              P=0.202          (e)             | 
|POLY 1.5           |        P=0.338          P=0.095          (e)              (e)              P=0.204          (e)             | 
|POLY 6             |        P=0.328          P=0.095          (e)              (e)              P=0.202          (e)             | 
|LOGISTIC REGRESSION|        (e)              P=0.111          (e)              (e)              P=0.204          (e)             | 
|COCH-ARM / FISHERS |        P=0.404N         P=0.105          (e)              (e)              P=0.237          (e)             | 
|ORDER RESTRICTED   |        P=0.823          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       1/10 (10%)       0/10 (0%)        1/10 (10%)       0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        1/10.00          1/10.00          0/10.00          1/8.06           0/9.11           0/0.03          | 
|POLY-3 PERCENT (g) |        10.0%            10.0%            0.0%             12.4%            0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        1/10 (10%)       1/10 (10%)       0/10 (0%)        1/8 (13%)        0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           29 (T)           ---              29 (T)           ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.537N         P=0.766          P=0.500N         P=0.716          P=0.521N         P=1.000N        | 
|POLY 3             |        P=0.355N         P=0.760          P=0.500N         P=0.711          P=0.518N         P=0.760N        | 
|POLY 1.5           |        P=0.348N         P=0.760          P=0.500N         P=0.719          P=0.514N         P=0.750N        | 
|POLY 6             |        P=0.357N         P=0.760          P=0.500N         P=0.709          P=0.521N         P=0.760N        | 
|LOGISTIC REGRESSION|        P=0.537N         P=0.766          (e)              P=0.721          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.241N         P=0.763N         P=0.500N         P=0.763N         P=0.500N         P=0.500N        | 
|ORDER RESTRICTED   |        P=0.829N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        1/10 (10%)       4/10 (40%)       2/10 (20%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          1/10.00          4/10.00          2/9.01           0/0.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             10.0%            40.0%            22.2%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        1/10 (10%)       4/10 (40%)       2/9 (22%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              29 (T)           29 (T)           29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.078          (e)              P=0.500          P=0.051          P=0.210          (e)             | 
|POLY 3             |        P=0.019 *        (e)              P=0.500          P=0.033 *        P=0.202          (e)             | 
|POLY 1.5           |        P=0.023 *        (e)              P=0.500          P=0.033 *        P=0.204          (e)             | 
|POLY 6             |        P=0.019 *        (e)              P=0.500          P=0.033 *        P=0.202          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.500          P=0.051          P=0.204          (e)             | 
|COCH-ARM / FISHERS |        P=0.554N         (e)              P=0.500          P=0.043 *        P=0.237          (e)             | 
|ORDER RESTRICTED   |        P=0.821          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/2 (0%)         0/10 (0%)        1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.06           0/9.11           1/1.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             97.6%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007 **       (e)              (e)              (e)              (e)              P=0.136         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.244         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.255         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.243         | 
|LOGISTIC REGRESSION|        P=0.733          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.250          (e)              (e)              (e)              (e)              P=0.500         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        3/10 (30%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           3/3.05          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.5%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.074         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.004 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.005 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|LOGISTIC REGRESSION|        P=0.559          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.031 *        (e)              (e)              (e)              (e)              P=0.105         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       0/0 (0%)         0/0 (0%)         0/2 (0%)         1/10 (10%)       4/10 (40%)      | 
|POLY-3 RATE (b)    |        2/10.00          0/0.00           0/0.00           0/0.06           1/9.11           4/4.02          | 
|POLY-3 PERCENT (g) |        20.0%            0.0%             0.0%             0.0%             11.0%            99.4%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        2/10 (20%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           ---              ---              ---              29 (T)           2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=1.000          P=1.000N         P=1.000N         P=0.539N         P=0.008 **      | 
|POLY 3             |        (e)              (e)              (e)              P=0.807N         P=0.533N         P=0.022 *       | 
|POLY 1.5           |        (e)              (e)              (e)              P=0.785N         P=0.525N         P=0.029 *       | 
|POLY 6             |        (e)              (e)              (e)              P=0.811N         P=0.537N         P=0.022 *       | 
|LOGISTIC REGRESSION|        P=0.591          (e)              (e)              (e)              P=0.539N         (e)             | 
|COCH-ARM / FISHERS |        P=0.179          P=1.000          P=1.000          P=0.682N         P=0.500N         P=0.314         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|INT SACRIFICE 1 (c)|                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/2 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.06           0/9.11           2/2.02          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.0%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              5               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.017 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.041 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.045 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        P=0.505          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.077          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|INT SACRIFICE 1 (c)|                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/2 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.06           0/9.11           0/0.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           2/2.05          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             97.4%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       (e)              (e)              (e)              (e)              P=0.185         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.041 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.050         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        P=0.709          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.089          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/2 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.06           0/9.11           2/2.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.6%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.093         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.041 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.046 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        P=0.787          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.077          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           0/0.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        6/10 (60%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/8.06           0/9.11           6/6.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/8 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.192          (e)              (e)              (e)              (e)              P=0.974         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.005 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/9.01           4/4.04          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.1%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.028 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.414          (e)              (e)              (e)              (e)              P=0.999         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.043 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        4/10 (40%)       9/10 (90%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/8.06           4/10.00          9/9.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             40.0%            100.0%          | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/8 (0%)         3/9 (33%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              14               2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.049 *        P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.033 *        P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.033 *        P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.033 *        P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.043 *        P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        7/10 (70%)       9/10 (90%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          7/10.00          9/9.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             70.0%            100.0%          | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        6/9 (67%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              6                2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.003 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.002 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       3/10 (30%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/8.06           1/10.00          3/3.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             10.0%            99.8%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/8 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              14               6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|POLY 3             |        P=0.003 **       (e)              (e)              (e)              P=0.500          P=0.003 **      | 
|POLY 1.5           |        P=0.003 **       (e)              (e)              (e)              P=0.500          P=0.004 **      | 
|POLY 6             |        P=0.003 **       (e)              (e)              (e)              P=0.500          P=0.003 **      | 
|LOGISTIC REGRESSION|        P=0.423          (e)              (e)              (e)              (e)              P=0.969         | 
|COCH-ARM / FISHERS |        P=0.002 **       (e)              (e)              (e)              P=0.500          P=0.105         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        8/10 (80%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/9.01           8/8.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.091          (e)              (e)              (e)              (e)              P=0.996         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/8.06           3/9.11           0/0.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             32.9%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/8 (0%)         3/9 (33%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008 **       (e)              (e)              (e)              P=0.093          (e)             | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.078          (e)             | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.082          (e)             | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.076          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.093          (e)             | 
|COCH-ARM / FISHERS |        P=0.313          (e)              (e)              (e)              P=0.105          (e)             | 
|ORDER RESTRICTED   |        P=0.823          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          3/10.00          0/0.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             30.0%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/9 (22%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              6                ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.073          (e)              (e)              (e)              P=0.108          (e)             | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.095          (e)             | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.095          (e)             | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.095          (e)             | 
|LOGISTIC REGRESSION|        P=0.559          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.313          (e)              (e)              (e)              P=0.105          (e)             | 
|ORDER RESTRICTED   |        P=0.817          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        4/10 (40%)       9/10 (90%)       9/10 (90%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          4/10.00          9/9.03           9/9.11           0/0.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             40.0%            99.7%            98.8%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        4/10 (40%)       8/8 (100%)       9/9 (100%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              29 (T)           9                29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.051          P<0.001 **       P<0.001 **       (e)             | 
|POLY 3             |        P<0.001 **       (e)              P=0.033 *        P<0.001 **       P<0.001 **       (e)             | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.033 *        P<0.001 **       P<0.001 **       (e)             | 
|POLY 6             |        P<0.001 **       (e)              P=0.033 *        P<0.001 **       P<0.001 **       (e)             | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.051          P<0.001 **       P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P=0.531          (e)              P=0.043 *        P<0.001 **       P<0.001 **       (e)             | 
|ORDER RESTRICTED   |        P=0.812          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        10/10 (100%)     8/10 (80%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          10/10.00         8/10.00          0/0.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             100.0%           80.0%            0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        10/10 (100%)     7/9 (78%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              29 (T)           6                ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       (e)             | 
|POLY 3             |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       (e)             | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       (e)             | 
|POLY 6             |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       (e)             | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P<0.001 **       (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.359          (e)              (e)              P<0.001 **       P<0.001 **       (e)             | 
|ORDER RESTRICTED   |        P=0.777          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        3/10 (30%)       7/10 (70%)       10/10 (100%)     0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          3/10.00          7/9.03           10/10.00         0/0.03          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             30.0%            77.5%            100.0%           0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        3/10 (30%)       6/8 (75%)        9/9 (100%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              29 (T)           9                14               ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.111          P=0.002 **       P<0.001 **       (e)             | 
|POLY 3             |        P<0.001 **       (e)              P=0.095          P<0.001 **       P<0.001 **       (e)             | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.095          P<0.001 **       P<0.001 **       (e)             | 
|POLY 6             |        P<0.001 **       (e)              P=0.095          P<0.001 **       P<0.001 **       (e)             | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.111          P=0.002 **       (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.369          (e)              P=0.105          P=0.002 **       P<0.001 **       (e)             | 
|ORDER RESTRICTED   |        P=0.814          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        8/10 (80%)       10/10 (100%)     0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          8/10.00          10/10.00         0/0.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             80.0%            100.0%           0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        8/10 (80%)       9/9 (100%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              29 (T)           6                ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       (e)             | 
|POLY 3             |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       (e)             | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       (e)             | 
|POLY 6             |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **       (e)             | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P<0.001 **       (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.220          (e)              (e)              P<0.001 **       P<0.001 **       (e)             | 
|ORDER RESTRICTED   |        P=0.770          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/8.06           0/9.11           4/4.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/8 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              5               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.185          (e)              (e)              (e)              (e)              P=0.861         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.043 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        6/10 (60%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/9.01           6/6.02          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.7%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.003 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.226          (e)              (e)              (e)              (e)              P=0.996         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.005 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/10 (0%)        2/10 (20%)       1/10 (10%)       9/10 (90%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/10.00          2/10.00          1/9.11           9/9.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             20.0%            11.0%            99.9%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/10 (0%)        0/8 (0%)         1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              9                29 (T)           2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.237          P=0.479          P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              P=0.227          P=0.481          P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              P=0.227          P=0.486          P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              P=0.227          P=0.479          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.724          (e)              (e)              (e)              P=0.479          (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.237          P=0.500          P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|INT SACRIFICE 1 (c)|                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         1/3 (33%)        0/10 (0%)        4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           1/2.03           0/9.11           4/4.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             49.3%            0.0%             100.0%          | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              9                ---              5               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.500          (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              P=0.181          (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              P=0.189          (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              P=0.180          (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.727          (e)              (e)              (e)              (e)              P=0.861         | 
|COCH-ARM / FISHERS |        P=0.024 *        (e)              (e)              P=0.231          (e)              P=0.043 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)       2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           1/9.01           2/2.05          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             11.1%            97.4%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           6               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       (e)              (e)              (e)              P=0.479          P=0.185         | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.479          P=0.041 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.481          P=0.050         | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.479          P=0.040 *       | 
|LOGISTIC REGRESSION|        P=0.312          (e)              (e)              (e)              P=0.479          (e)             | 
|COCH-ARM / FISHERS |        P=0.132          (e)              (e)              (e)              P=0.500          P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       0/0 (0%)         0/0 (0%)         0/3 (0%)         3/10 (30%)       5/10 (50%)      | 
|POLY-3 RATE (b)    |        2/10.00          0/0.00           0/0.00           0/1.06           3/10.00          5/5.03          | 
|POLY-3 PERCENT (g) |        20.0%            0.0%             0.0%             0.0%             30.0%            99.4%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        2/10 (20%)       0/0 (0%)         0/0 (0%)         0/1 (0%)         2/9 (22%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           ---              ---              ---              14               2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=1.000          P=1.000N         P=0.795N         P=0.460          P=0.009 **      | 
|POLY 3             |        (e)              (e)              (e)              P=0.693N         P=0.500          P=0.005 **      | 
|POLY 1.5           |        (e)              (e)              (e)              P=0.669N         P=0.500          P=0.008 **      | 
|POLY 6             |        (e)              (e)              (e)              P=0.698N         P=0.500          P=0.005 **      | 
|LOGISTIC REGRESSION|        P=0.524          (e)              (e)              (e)              (e)              P=0.977N        | 
|COCH-ARM / FISHERS |        P=0.079          P=1.000          P=1.000          P=0.577N         P=0.500          P=0.175         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           2/2.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             96.6%           | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.102         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.041 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.052         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.089          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|INT SACRIFICE 1 (c)|                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       1/1 (100%)       0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        2/10.00          1/1.00           0/0.00           0/0.00           0/9.01           0/0.07          | 
|POLY-3 PERCENT (g) |        20.0%            100.0%           0.0%             0.0%             0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        2/10 (20%)       1/1 (100%)       0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           29 (T)           ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.178N         P=0.305          P=1.000N         P=1.000N         P=0.257N         P=1.000N        | 
|POLY 3             |        (e)              P=0.286          (e)              (e)              P=0.252N         P=0.698N        | 
|POLY 1.5           |        (e)              P=0.286          (e)              (e)              P=0.249N         P=0.657N        | 
|POLY 6             |        (e)              P=0.286          (e)              (e)              P=0.252N         P=0.702N        | 
|LOGISTIC REGRESSION|        P=0.172N         P=0.305          (e)              (e)              P=0.251N         (e)             | 
|COCH-ARM / FISHERS |        P=0.044N*        P=0.273          P=1.000          P=1.000          P=0.237N         P=0.237N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 01                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -               BETA-BROMO-BETA-NITROSTYRENE             
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Bilateral                                                                                                                | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|INT SACRIFICE 1 (c)|                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Bilateral                                                                                                                | 
|     Hydrometra                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       1/1 (100%)       0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        2/10.00          1/1.00           0/0.00           0/0.00           0/9.01           0/0.07          | 
|POLY-3 PERCENT (g) |        20.0%            100.0%           0.0%             0.0%             0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|TERMINAL (d)       |        2/10 (20%)       1/1 (100%)       0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           29 (T)           ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.178N         P=0.305          P=1.000N         P=1.000N         P=0.257N         P=1.000N        | 
|POLY 3             |        (e)              P=0.286          (e)              (e)              P=0.252N         P=0.698N        | 
|POLY 1.5           |        (e)              P=0.286          (e)              (e)              P=0.249N         P=0.657N        | 
|POLY 6             |        (e)              P=0.286          (e)              (e)              P=0.252N         P=0.702N        | 
|LOGISTIC REGRESSION|        P=0.172N         P=0.305          (e)              (e)              P=0.251N         (e)             | 
|COCH-ARM / FISHERS |        P=0.044N*        P=0.273          P=1.000          P=1.000          P=0.237N         P=0.237N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.