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TDMS Study 61529-02 Pathology Tables

NTP Experiment-Test: 61529-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04
Route: GAVAGE                                                                                                     Time: 11:11:45




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  108-42-09

       Lock Date:  11/16/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 61529-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 11:11:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160             
                                                                                                                    MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Dosing Accident                                    1            1                         2                         1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9           10            8           10            9           
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (10)         (1)                       (2)                       (10)         
      Hemorrhage                                       1 (10%)                                                                      
      Ulcer                                                                                   1 (50%)                               
   Liver                                              (10)         (1)                       (2)          (9)          (10)         
      Hematopoietic Cell Proliferation                                                                     1 (11%)      7 (70%)     
      Necrosis, Focal                                                                                                   1 (10%)     
      Kupffer Cell, Pigmentation                                                                           9 (100%)     9 (90%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (1)                       (2)                       (10)         
      Pericardium, Inflammation, Suppurative                        1 (100%)                  1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                                           (1)          (1)          (2)                                    
      Cyst                                                                       1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
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NTP Experiment-Test: 61529-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 11:11:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160             
                                                                                                                    MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Pigmentation, Hemosiderin                                     4 (40%)      8 (80%)      7 (70%)     10 (100%)     9 (90%)     
      Erythroid Cell, Hyperplasia                                                                                       2 (20%)     
      Myeloid Cell, Hyperplasia, Diffuse                                                      1 (10%)                               
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                              2 (20%)      7 (70%)      7 (70%)     10 (100%)     9 (90%)     
      Pigmentation, Hemosiderin                                     9 (90%)     10 (100%)     8 (80%)     10 (100%)     9 (90%)     
   Thymus                                             (10)         (1)                       (2)                       (10)         
      Atrophy                                                                                 1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (1)                       (2)                       (10)         
      Foreign Body                                                                            2 (100%)                  1 (10%)     
      Hemorrhage                                       1 (10%)                                                                      
      Serosa, Inflammation, Suppurative                             1 (100%)                  2 (100%)                  1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (1)                       (2)                       (10)         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
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NTP Experiment-Test: 61529-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 11:11:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160             
                                                                                                                    MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Hyperplasia, Lymphoid                            1 (10%)                                                                      
      Infarct                                          1 (10%)                                                                      
      Pigmentation                                                                                                      6 (60%)     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 61529-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 11:11:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160             
                                                                                                                    MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Dosing Accident                                    1                         3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9           10            7           10           10           10           
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (10)                      (3)                                    (10)         
      Foreign Body                                                               1 (33%)                                            
      Inflammation, Suppurative                        1 (10%)                                                                      
      Perforation                                      1 (10%)                                                                      
   Liver                                              (10)                      (3)                       (3)          (10)         
      Hematopoietic Cell Proliferation                                                                                  8 (80%)     
      Kupffer Cell, Pigmentation                                                                           3 (100%)     9 (90%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                      (3)                                    (10)         
      Inflammation, Suppurative                                                  2 (67%)                                            
      Myocardium, Degeneration                                                                                          1 (10%)     
      Pericardium, Inflammation, Suppurative           1 (10%)                   1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 61529-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 11:11:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160             
                                                                                                                    MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Pigmentation, Hemosiderin                                                              10 (100%)    10 (100%)    10 (100%)    
      Erythroid Cell, Hyperplasia                                                                                       4 (40%)     
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                                           3 (30%)     10 (100%)    10 (100%)    10 (100%)    
      Pigmentation, Hemosiderin                                     1 (10%)      4 (40%)     10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                      (3)                                    (10)         
      Foreign Body                                     1 (10%)                   1 (33%)                                            
      Serosa, Inflammation, Suppurative                1 (10%)                   3 (100%)                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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