National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/16019

TDMS Study 60855-02 Pathology Tables

NTP Experiment-Test: 60855-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04
Route: GAVAGE                                                                                                     Time: 14:16:34




       Facility:  BIORELIANCE

       Chemical CAS #:  7166-19-0

       Lock Date:  04/23/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 60855-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:16:34    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.037        0.075        0.150        0.300        0.600           
                                                                G/KG         G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Dosing Accident                                                                           1                                     
    Natural Death                                                                                                       6           
    Moribund Sacrifice                                                                                                  4           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10            9           10                        
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (10)                                   (1)          (10)         (10)         
      Inflammation                                                                            1 (100%)                              
   Gallbladder                                        (8)          (10)         (10)         (8)          (7)          (9)          
      Hemorrhage                                                                                                        1 (11%)     
      Inflammation                                                                                         2 (29%)      7 (78%)     
      Necrosis                                                                                             1 (14%)      2 (22%)     
   Intestine Large, Colon                             (10)                                   (1)          (10)         (9)          
      Inflammation                                                                                                      1 (11%)     
   Intestine Large, Cecum                             (10)                                                (10)         (6)          
      Inflammation                                                                                                      1 (17%)     
   Liver                                              (10)                                   (1)          (10)         (10)         
      Depletion Glycogen                                                                      1 (100%)                  9 (90%)     
      Inflammation                                                                                                      2 (20%)     
      Necrosis                                                                                             1 (10%)      4 (40%)     
   Pancreas                                           (10)                                   (1)          (10)         (10)         
      Inflammation                                                                                         1 (10%)      4 (40%)     
      Necrosis                                                                                                          1 (10%)     
   Salivary Glands                                    (10)                                   (1)          (10)         (10)         
      Atrophy                                                                                                           1 (10%)     
      Inflammation                                                                                         1 (10%)                  
   Stomach, Forestomach                               (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation                                                                                                      8 (80%)     
      Necrosis                                                                                                          4 (40%)     
      Epithelium, Hyperkeratosis                                                                           2 (20%)                  
      Epithelium, Hyperplasia                                                                             10 (100%)                 
   Stomach, Glandular                                 (10)                                   (10)         (10)         (10)         
      Hemorrhage                                       1 (10%)                                                                      
      Inflammation                                                                                                      2 (20%)     
      Necrosis                                                                                                          1 (10%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:16:34    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.037        0.075        0.150        0.300        0.600           
                                                                G/KG         G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Uterus                                             (10)                                   (1)          (10)         (10)         
      Hydrometra                                       1 (10%)                                                                      
      Inflammation                                                                                         1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)                                   (1)          (10)         (10)         
      Erythroid Cell, Depletion Cellular                                                                                5 (50%)     
   Lymph Node, Mandibular                             (10)                                   (1)          (10)         (9)          
      Hemorrhage                                                                                           1 (10%)                  
      Necrosis                                                                                                          1 (11%)     
   Lymph Node, Mesenteric                             (10)                                                (10)         (9)          
      Atrophy                                                                                                           1 (11%)     
      Hyperplasia                                                                                          1 (10%)                  
      Necrosis                                                                                                          1 (11%)     
   Spleen                                             (10)                                   (2)          (10)         (10)         
      Atrophy                                                                                                           1 (10%)     
      Congestion                                                                                                        4 (40%)     
      Hematopoietic Cell Proliferation                                                                                  2 (20%)     
      Inflammation                                                                                                      2 (20%)     
      Necrosis                                                                                                          1 (10%)     
      Pigmentation                                                                            1 (50%)                               
   Thymus                                             (9)                                    (1)          (10)         (8)          
      Atrophy                                                                                                           2 (25%)     
      Necrosis                                                                                                          6 (75%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:16:34    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.037        0.075        0.150        0.300        0.600           
                                                                G/KG         G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                   (1)          (10)         (10)         
      Congestion                                                                              1 (100%)                  1 (10%)     
      Hemorrhage                                                                                           2 (20%)      1 (10%)     
      Mediastinum, Foreign Body                                                               1 (100%)                              
      Mediastinum, Inflammation                                                               1 (100%)                              
      Serosa, Foreign Body                                                                    1 (100%)                              
      Serosa, Inflammation                                                                    1 (100%)                              
   Nose                                               (10)                                   (1)          (10)         (10)         
      Inflammation                                                                                         1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                   (1)          (10)         (10)         
      Congestion                                                                                                        3 (30%)     
   Urinary Bladder                                    (10)                                   (1)          (10)         (10)         
      Hemorrhage                                                                                                        1 (10%)     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:16:34    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.037        0.075        0.150        0.300        0.600           
                                                                G/KG         G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                          1            4           
    Moribund Sacrifice                                                                                                  6           
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9            9           10            9                        
    Accidently Killed                                  1            1            1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (10)                                                (10)         (9)          
      Inflammation                                     1 (10%)                                             1 (10%)                  
   Gallbladder                                        (9)          (10)         (10)         (10)         (8)          (5)          
      Degeneration                                                                                         1 (13%)      4 (80%)     
      Hemorrhage                                                                                           1 (13%)                  
      Inflammation                                                                                         3 (38%)      5 (100%)    
   Intestine Small, Jejunum                           (10)                                                (9)          (10)         
      Hemorrhage                                                                                                        1 (10%)     
      Inflammation                                                                                                      4 (40%)     
      Peyer's Patch, Necrosis                                                                                           1 (10%)     
   Liver                                              (10)                                                (10)         (10)         
      Depletion Glycogen                                                                                   1 (10%)     10 (100%)    
      Necrosis                                                                                                          2 (20%)     
   Pancreas                                           (10)                                                (10)         (10)         
      Inflammation                                                                                                      6 (60%)     
      Necrosis                                                                                                          3 (30%)     
   Stomach, Forestomach                               (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation                                                                                                      1 (10%)     
      Ulcer                                                                                                2 (20%)                  
      Epithelium, Hyperkeratosis                                                                           9 (90%)                  
      Epithelium, Hyperplasia                                                                              9 (90%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:16:34    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.037        0.075        0.150        0.300        0.600           
                                                                G/KG         G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)                                                (10)         (10)         
      Granuloma Sperm                                                                                                   1 (10%)     
   Testes                                             (10)                                                (10)         (10)         
      Degeneration                                                                                                      6 (60%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)                                                (10)         (10)         
      Erythroid Cell, Depletion Cellular                                                                                5 (50%)     
   Lymph Node, Mandibular                             (9)                                                 (7)          (9)          
      Atrophy                                                                                                           2 (22%)     
      Necrosis                                                                                                          1 (11%)     
   Lymph Node, Mesenteric                             (10)                                                (10)         (10)         
      Atrophy                                                                                                           3 (30%)     
      Inflammation                                                                                                      1 (10%)     
      Necrosis                                                                                                          2 (20%)     
   Spleen                                             (10)                                                (10)         (10)         
      Atrophy                                                                                                           6 (60%)     
      Congestion                                                                                                        3 (30%)     
      Lymphoid Follicle, Necrosis                                                                                       1 (10%)     
   Thymus                                             (10)                                                (10)         (10)         
      Atrophy                                                                                                           3 (30%)     
      Hemorrhage                                                                                           1 (10%)                  
      Necrosis                                                                                                          8 (80%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 60855-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 18-33 DAYS                                 BETA-BROMO-BETA-NITROSTYRENE                               Date: 10/19/04    
Route: GAVAGE                                                                                                     Time: 14:16:34    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.037        0.075        0.150        0.300        0.600           
                                                                G/KG         G/KG         G/KG         G/KG         G/KG            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                (10)         (10)         
      Congestion                                                                                                        3 (30%)     
      Hemorrhage                                       1 (10%)                                                          1 (10%)     
   Nose                                               (10)                                                (10)         (10)         
      Inflammation                                                                                         1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                (10)         (10)         
      Congestion                                                                                           1 (10%)      5 (50%)     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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