National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17637

TDMS Study 88004-05 Pathology Tables

NTP  EXP/TEST: 88004-05                                  DIVINYLBENZENE                                           PAGE: 1
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 12/17/03
ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                                                            TIME: 11:34:43

                                                         EIS REPORT 03


       FACILITY:  Battelle Northwest

       NTP C#:  88004B

       CONTRACT NUMBER:  NO1-ES-75410

       CAS NUMBER:  1321-74-0

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 88004-05                                  DIVINYLBENZENE                                           PAGE: 2
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 12/17/03
ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                      EISRPT03                                              TIME: 11:34:43
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 SPECIES-STRAIN: F 344-RATS                 SEX: FEMALE      WEEK ON DOSE: 105    FIRST DOSE: 09/13/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 CONTROL            50     80.1    6.8        33    355.3   37.5                     33    274.0   36.3

 100 PPM            50     78.5    7.1        30    342.4   29.3        96.3         30    264.6   32.0

 200 PPM            50     78.6    6.7        33    339.7   29.6        95.6         33    262.4   30.9

 400 PPM            50     78.3    6.6        22    316.7   28.0        89.1         22    237.6   28.1




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 SPECIES-STRAIN: F 344-RATS                 SEX: MALE        WEEK ON DOSE: 105    FIRST DOSE: 09/13/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 CONTROL            50     93.2    8.3        31    508.6   44.7                     31    414.9   44.3

 100 PPM            50     91.4    8.8        35    525.5   44.8       103.3         35    432.9   44.7

 200 PPM            50     91.1    8.3        31    504.0   55.0        99.0         31    412.8   54.4

 400 PPM            50     91.4   10.7        32    471.9   39.4        92.7         32    379.8   38.2

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