National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17683

TDMS Study 92013-05 Pathology Tables

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 1
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                                                                                 TIME: 09:48:49

                                                         EIS REPORT 12


       FACILITY:  Southern Research Institute

       NTP C#:  92013B

       CONTRACT NUMBER:  N01-ES-85420

       CAS NUMBER:  822-36-6

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 2
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 0 PPM              TRT#:  2         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      13      20      27      34      41      48      55      62      69      76      83      90
----------------------------------------------------------------------------------------------------------------------------------

  69    201    99.5   126.3   132.9   143.9   150.6   155.6   162.8   165.5   168.3   169.4   171.7   178.3   176.4
  69    202   111.8   139.2   147.6   155.9   160.2   169.2   176.0   187.5   184.3   189.1   194.9   194.1   198.4
  69    203    98.7   136.4   147.1   154.6   163.2   172.7   179.1   191.9   187.2   195.7   199.3   198.6   203.0
  69    204    95.3   121.5   133.4   139.8   146.4   152.6   157.4   166.5   167.3   171.0   176.8   174.9   179.5
  69    205   107.4   138.7   146.9   158.4   167.1   172.9   183.3   188.7   189.9   194.5   200.0   200.7   203.4
  70    206   102.1   138.3   146.7   157.6   166.4   171.9   179.9   189.7   194.9   196.5   196.0   196.5   196.9
  70    207   108.7   141.4   151.9   163.6   170.8   179.8   185.7   198.1   202.5   203.7   207.8   207.6   213.2
  70    208    89.1   120.3   130.1   135.2   144.7   149.9   155.2   160.9   163.6   167.0   170.1   169.2   174.1
  70    209   106.0   131.9   141.2   151.8   160.2   169.9   176.1   186.1   185.5   187.6   192.6   191.9   195.1
  70    210    86.4   115.9   126.9   137.2   145.4   150.7   156.3   161.6   166.2   168.4   171.1   175.2   176.9
  71    211    93.5   120.3   132.5   141.0   152.8   162.5   172.0   180.3   185.2   184.0   188.7   189.1   192.8
  71    212   103.4   130.0   138.2   149.5   155.6   161.8   174.9   183.9   181.4   183.6   184.3   185.9   189.1
  71    213   108.6   121.1   142.0   147.5   157.5   162.9   175.2   181.4   184.3   182.6   187.0   187.6   191.1
  71    214   103.7   133.8   141.8   153.4   163.1   171.8   181.0   192.4   193.8   197.9   196.5   196.4   203.5
  71    215    94.4   116.1   122.1   130.3   138.3   147.5   152.1   159.4   160.1   160.3   163.9   162.1   163.9
  72    216   112.1   136.1   144.6   151.3   159.3   164.8   174.9   182.3   184.3   186.8   190.1   186.0   191.3
  72    217   102.1   129.2   136.8   150.4   159.2   164.7   169.9   176.8   169.8   178.2   178.7   179.0   183.1
  72    218   102.3   116.5   124.8   131.1   139.6   149.7   152.9   161.0   160.5   165.9   169.6   170.3   171.2
  72    219   101.6   127.2   133.4   140.8   149.2   154.8   166.0   168.7   169.7   172.9   176.8   179.9   180.0
  72    220    85.8   114.4   126.9   136.0   143.5   151.0   159.5   147.3   164.7   171.5   172.9   173.9   174.8
  73    221   101.3   138.3   146.6   158.3   162.4   176.2   177.2   184.2   190.8   193.2   202.4   201.1   206.0
  73    222   112.7   137.4   144.6   159.5   159.7   164.5   172.6   180.8   177.4   187.8   192.8   190.3   192.6
  73    223   110.2   137.2   143.0   153.7   159.9   164.8   172.1   180.6   182.8   189.4   190.1   189.4   194.9
  73    224   106.2   142.3   154.0   165.9   175.8   184.0   187.0   195.4   202.7   204.2   211.1   211.3   213.2
  73    225    87.2   120.2   128.3   137.4   147.2   157.5   163.6   171.2   174.1   178.1   182.7   185.8   189.7
  74    226    99.9   129.2   137.4   151.1   154.4   162.8   169.2   174.1   178.8   184.6   191.5   193.0   196.7
  74    227   109.0   133.2   143.3   154.8   158.7   164.5   167.1   174.4   173.1   176.6   180.0   180.4   184.5
  74    228    85.5   110.9   123.0   131.6   136.8   146.5   149.6   158.6   157.5   162.5   166.4   165.4   172.3
  74    229   104.4   128.3   141.7   151.7   157.2   163.7   169.5   173.6   177.7   180.6   185.9   186.2   191.1
  74    230    86.9   120.0   131.8   145.0   150.9   154.5   160.6   166.0   167.9   172.3   177.2   180.2   184.0
  75    231   110.8   139.1   151.2   162.5   170.3   178.9   181.2   192.7   192.6   192.6   200.9   201.9   204.1
  75    232   102.9   138.6   153.5   166.7   172.1   181.7   186.2   198.0   196.6   201.0   207.7   209.3   212.8
  75    233   102.5   126.3   133.1   145.2   147.6   156.0   158.4   164.3   164.1   167.8   169.2   169.2   170.2
  75    234    94.9   127.9   140.3   147.6   155.5   162.5   163.2   171.8   169.6   175.8   180.0   180.6   184.9
  75    235    95.8   131.4   144.6   156.4   160.7   171.2   178.5   184.8   183.6   191.7   196.4   197.2   199.7
  76    236    93.8   122.5   132.3   141.0   151.0   157.1   162.3   172.5   170.7   173.9   176.1   178.0   180.5
  76    237   109.2   133.5   144.3   158.2   165.2   174.5   176.4   186.9   183.2   192.6   196.0   197.7   198.2
  76    238    95.6   125.6   135.1   146.7   149.4   159.7   163.6   171.1   168.7   176.7   180.4   181.5   186.5
  76    239    99.5   127.8   139.5   147.0   154.1   159.0   164.8   170.9   171.0   176.4   183.8   181.8   188.2
  76    240   111.7   141.5   152.3   168.1   174.3   181.8   188.9   195.8   196.4   202.4   204.3   207.0   206.6
  77    241    97.1   131.6   142.5   155.6   159.9   171.8   177.2   181.9   185.6   189.5   195.8   196.9   202.1
  77    242   105.3   134.8   142.2   150.2   155.1   161.5   164.5   172.8   174.6   181.0   183.6   182.8   190.3
  77    243   104.9   132.2   139.6   151.0   157.7   163.3   167.0   179.0   182.6   189.6   193.8   196.0   194.5
  77    244    99.4   117.8   126.5   134.7   139.2   147.6   146.4   150.6   153.6   158.4   164.1   163.7   166.9
  77    245    89.1    74.1 @
  78    246    99.0   125.8   134.2   145.5   155.7   163.0   167.1   173.1   175.3   180.5   187.3   192.7   194.8
  78    247    91.4   116.8   130.7   141.1   148.5   159.6   157.6   166.3   168.2   173.6   182.3   182.4   185.6

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 3
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 0 PPM              TRT#:  2         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      13      20      27      34      41      48      55      62      69      76      83      90
----------------------------------------------------------------------------------------------------------------------------------

  78    248   106.8   129.5   139.6   150.1   156.6   162.2   168.3   173.2   170.8   180.6   184.4   185.8   189.1
  78    249    79.2   112.1   123.0   133.2   137.6   145.2   149.9   155.7   156.0   160.9   166.9   166.2   170.3
  78    250   101.6   128.4   134.9   147.1   152.0   161.7   165.4   172.2   173.9   176.7   182.3   185.3   186.2
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    100.1   127.4   138.4   148.7   155.5   163.1   168.7   176.0   177.2   181.6   185.8   186.5   189.7

SD              8.2    11.4     8.5     9.8     9.6     9.9    10.7    12.5    12.2    12.0    12.3    12.3    12.4

NO. OBSER.       50      50      49      49      49      49      49      49      49      49      49      49      49

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 4
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 0 PPM              TRT#:  2         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       118     146     174     202     230     258     286     314     342     370     398     426     454
----------------------------------------------------------------------------------------------------------------------------------

  69    201   189.0   200.9   202.8   211.4   216.1   216.3   218.0   230.4   233.3   240.3   243.2   252.6   268.1
  69    202   202.3   214.5   219.5   229.3   229.5   235.0   233.7   244.9   253.7   261.1   273.4   290.9   292.6
  69    203   204.7   212.3   220.6   227.7   228.6   232.8   234.2   246.1   249.9   258.9   273.9   279.1   285.0
  69    204   180.9   189.4   195.9   199.5   200.0   206.1   201.7   210.0   218.3   214.3   226.0   244.7   244.6
  69    205   210.3   217.7   226.5   233.9   238.7   240.5   241.9   255.4   256.0   258.4   265.7   279.0   278.2
  70    206   201.6   207.9   219.0   225.3   235.5   234.2   228.1   237.7   234.9   239.9   240.4   253.0   268.4
  70    207   221.0   229.5   241.2   243.5   256.5   258.1   263.8   271.2   282.1   285.6   296.0   311.9   324.3
  70    208   180.5   191.6   203.5   201.9   213.9   210.1   212.4   215.3   220.2   223.4   230.9   241.0   256.6
  70    209   199.3   209.4   221.9   226.0   233.5   230.6   235.9   246.4   250.0   265.3   270.9   284.5   290.3
  70    210   186.3   192.9   202.0   209.8   217.9   217.8   217.6   226.7   221.8   235.8   238.6   250.5   263.6
  71    211   195.0   208.6   210.8   228.5   230.9   240.3   240.7   257.6   267.2   276.3   284.7   298.1   291.6
  71    212   189.6   197.3   206.2   207.2   220.4   223.1   221.4   233.0   235.4   242.1   246.1   282.7   269.1
  71    213   192.8   199.5   209.1   214.1   225.8   226.6   224.0   232.4   233.6   241.4   240.3   275.8   265.2
  71    214   208.9   213.6   226.7   236.6   244.1   242.1   248.2   255.7   261.7   270.0   278.3   303.0   295.1
  71    215   171.0   179.9   188.0   192.9   200.0   200.4   202.4   208.6   212.3   218.0   220.6   244.6   234.9
  72    216   198.1   206.1   213.9   221.6   229.5   232.2   234.8   239.6   247.1   257.2   273.1   277.8   288.1
  72    217   191.3   197.6   207.6   207.5   212.2   219.5   220.9   227.2   230.0   238.3   238.4   263.3   263.9
  72    218   177.9   182.4   192.0   201.7   201.5   208.8   212.1   213.7   217.3   222.6   229.1   245.6   254.5
  72    219   186.3   194.1   200.7   207.7   209.5   216.1   221.4   219.4   228.0   237.2   237.7   247.8   262.7
  72    220   181.2   192.1   202.4   208.7   209.6   216.0   219.6   225.4   232.2   248.4   264.4   272.4   280.5
  73    221   211.1   221.6   231.0   238.8   245.9   254.1   246.2   271.2   273.0   288.2   303.5   314.4   324.3
  73    222   197.7   207.7   213.2   220.3   224.0   237.6   229.3   251.2   265.4   271.5   275.5   283.5   289.7
  73    223   197.9   206.6   214.3   218.4   222.9   233.1   228.6   243.3   246.2   248.2   256.8   262.3   277.0
  73    224   220.3   233.5   234.1   240.4   247.3   250.7   255.1   275.4   280.8   283.3   292.7   310.7   328.7
  73    225   193.6   206.2   208.7   217.4   224.7   228.2   226.5   242.9   244.9   252.2   262.6   268.4   289.2
  74    226   200.1   208.3   213.0   228.2   224.2   235.6   230.1   239.9   243.3   252.5   260.0   267.6   270.8
  74    227   186.7   197.3   205.7   209.5   216.6   225.4   233.2   235.7   237.9   247.0   248.8   260.2   259.4
  74    228   177.8   189.6   200.7   205.7   208.2   211.9   214.4   223.7   229.1   235.8   243.5   254.3   259.7
  74    229   188.7   199.8   210.2   216.4   217.8   222.9   225.2   233.0   235.7   237.5   242.6   253.9   260.2
  74    230   192.1   197.5   204.2   207.1   210.4   218.2   219.6   224.5   231.2   231.7   235.7   242.0   246.4
  75    231   205.2   213.6   223.0   224.9   233.4   238.8   234.1   246.9   246.5   257.5   258.1   275.1   274.5
  75    232   216.0   230.5   237.5   241.5   249.6   256.7   250.2   272.2   277.0   289.6   308.8   319.2   324.5
  75    233   174.4   185.1   191.1   194.3   200.8   210.0   206.3   217.2   213.5   222.7   226.4   229.5   238.4
  75    234   186.7   196.7   206.8   208.8   214.8   223.5   219.9   230.3   229.4   236.4   238.4   245.9   253.3
  75    235   199.8   211.4   221.2   224.4   233.5   239.5   234.2   254.6   258.4   274.2   243.1   296.5   308.9
  76    236   185.2   195.0   204.5   205.4   214.7   219.2   209.8   225.7   229.1   237.8   244.9   243.9   253.5
  76    237   202.9   211.0   218.2   227.5   230.6   240.5   232.4 @
  76    238   191.8   199.2   210.7   209.5   214.7   219.4   216.3   235.3   238.2   247.1   254.8   270.8   273.1
  76    239   196.3   203.7   211.0   215.3   218.7   223.6   215.5   234.5   233.8   240.7   254.7   269.2   278.8
  76    240   219.3   232.9   234.4   248.4   252.8   262.2   257.6   286.0   304.9   314.7   227.4   334.5   330.1
  77    241   208.2   216.0   210.1   223.2   235.3   244.7   247.3   253.7   262.4   276.9   280.0   286.3   292.8
  77    242   192.9   209.1   218.5   218.3   222.2   236.8   231.5   240.9   247.6   255.3   269.7   284.1   289.0
  77    243   196.7   208.4   217.1   215.8   225.4   227.3   236.6   237.3   239.6   252.2   255.4   267.9   275.8
  77    244   173.6   187.2   191.3   192.1   200.2   207.2   209.3   212.1   213.7   221.7   228.2   233.9   238.0
  77    245
  78    246   196.6   204.1   216.6   228.0   232.4   237.5   237.2   247.9   249.0   259.4   264.5   276.0   277.4
  78    247   187.7   200.9   207.9   212.4   221.4   228.4   228.7   239.3   235.6   249.7   253.8   264.5   275.6

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 5
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 0 PPM              TRT#:  2         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       118     146     174     202     230     258     286     314     342     370     398     426     454
----------------------------------------------------------------------------------------------------------------------------------

  78    248   193.0   201.5   210.8   212.4   219.5   227.6   222.9   230.0   230.3   239.7   238.5   237.2   231.9
  78    249   173.0   183.0   193.7   196.7   204.5   213.0   213.0   219.2   229.8   233.7   241.0   248.2   247.6
  78    250   194.0   195.6   207.4   212.9   212.0   215.4   214.5   223.3   225.6   237.1   246.0   265.4   272.1
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    194.4   203.9   211.8   217.3   223.1   228.5   227.7   238.4   242.4   250.6   254.7   270.1   275.4

SD             12.4    12.8    12.3    13.7    14.3    14.5    14.3    18.0    19.9    21.1    21.4    24.3    24.7

NO. OBSER.       49      49      49      49      49      49      49      48      48      48      48      48      48

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 6
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 0 PPM              TRT#:  2         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       482     510     538     566     594     622     650     678     706
----------------------------------------------------------------------------------------------------------------------------------

  69    201   267.1   275.1   283.0   299.5   299.9   297.7   305.1   316.5   320.6
  69    202   292.4   295.4   305.1   306.5   315.4   313.8   316.0   327.2   329.0
  69    203   292.6   290.2   292.7   305.1   303.9   301.6   303.6   318.8   324.7
  69    204   247.3   248.3   261.6   267.2   270.5   269.0   273.2   277.2   284.8
  69    205   287.8   287.6   296.3   300.2   308.0   306.0   311.0   315.3   314.2
  70    206   261.2   270.4   274.6   280.3   282.4   284.3   289.3   289.6   291.6
  70    207   324.8   327.1   337.0   333.5   338.5   349.1   353.8   344.8   368.7
  70    208   249.8   255.8   262.9   268.2   273.8   281.4   291.3   299.0   309.0
  70    209   292.2   292.7   304.4   305.2   308.3   317.7   319.5   319.8   312.2
  70    210   265.1   269.6   278.7   281.0   288.2   288.1   294.2   291.3   301.1
  71    211   296.7   297.6   304.2   314.5   312.4   320.8   325.2   329.0   329.7
  71    212   272.0   270.9   285.2   287.8   285.6   291.5   295.7   290.5   300.4
  71    213   263.5   258.7   271.6   282.4   273.8   288.5   294.3   296.1   311.5
  71    214   304.8   310.2   312.0   318.8   317.3   317.1   324.1   320.3   329.6
  71    215   235.5   233.6   238.3   244.6   246.8   254.8   265.9   265.7   273.1
  72    216   290.9   292.3   300.8   300.3   295.5   298.4   312.9   318.1   319.6
  72    217   258.5   269.0   276.7   284.7   285.0   294.9   301.9   304.6   312.7
  72    218   250.0   249.1   260.4   261.1   260.2   271.7   274.2   276.7   284.2
  72    219   260.1   263.1   269.7   284.7   285.9   291.3   297.6   302.9   308.1 @
  72    220   281.6   290.0   299.1   309.6   302.2   295.9 @
  73    221   327.4   327.1   332.6   328.5   335.9   331.8   316.4   324.0 @
  73    222   294.7   301.7   310.2   311.6   314.0   322.7   329.0   328.1   329.0
  73    223   277.1   285.6   293.6   303.0   299.7   309.0   315.2   310.5   327.0
  73    224   330.1   333.9   348.1   344.8   352.8   363.0   360.7   309.7   334.9 @
  73    225   289.4   290.2   289.8   295.1   278.6   287.9   288.2   247.7   280.1
  74    226   281.6   286.6   289.7   294.9   299.4   299.1   302.6   258.7   315.2
  74    227   273.1   271.2   277.5   284.8   288.8   301.7   304.8   276.0   319.9
  74    228   267.5   278.3   274.4   281.6   288.3   286.4   293.9   257.5   298.2
  74    229   275.1   280.9   286.2   289.9   281.5   295.2   308.8   268.8   311.7
  74    230   253.8   259.4   262.6   264.4   264.5   267.5   276.8   241.0   278.6
  75    231   281.0   291.7   297.7   301.7   304.1   311.5   317.4   312.4   309.8 @
  75    232   327.2   329.8   335.3   335.5   333.7   335.6   346.8   353.2   355.6
  75    233   241.1   246.7   250.1   265.0   265.0   272.7   274.5   280.3   292.7
  75    234   259.6   261.5   268.0   281.4   280.7   288.3   291.2   290.6   294.9
  75    235   312.9   318.7   318.1   323.2   325.6   332.5   335.1   326.7   349.4
  76    236   263.7   263.6   272.5   280.1   284.2   289.9   275.1 @
  76    237
  76    238   278.2   273.6   279.9   286.4   286.3   286.6   295.8   289.4   305.8
  76    239   288.0   289.2   291.3   303.7   303.2   303.3   308.5   293.9   273.9
  76    240   333.5   344.2   350.8   354.2   342.4   346.1   350.1   338.6   347.6
  77    241   298.0   305.2   311.0   316.6   313.3   310.0   315.7   326.4   326.5
  77    242   248.0   295.3   300.8   310.2   317.3   303.4   274.4   275.4   245.7
  77    243   280.6   278.2   277.5   275.5   271.8   278.4   278.5   286.1   298.7
  77    244   244.9   255.4   256.9   265.6   270.6   279.9   290.7   225.1 @
  77    245
  78    246   290.1   298.7   306.5   311.9   311.5   314.8   324.0   333.5   339.5
  78    247   281.9   290.1   297.1   305.3   309.9   312.1   319.9   324.5   323.0

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 7
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 0 PPM              TRT#:  2         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       482     510     538     566     594     622     650     678     706
----------------------------------------------------------------------------------------------------------------------------------

  78    248   228.3 @
  78    249   253.8   258.7   268.2   280.3   285.4   286.4   291.0   296.3   299.3
  78    250   278.9   288.4   291.0   300.7   300.2   306.3   303.6   300.8   304.0
              -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    278.2   284.1   290.5   296.4   297.1   301.2   305.2   299.5   311.3

SD             25.5    24.7    24.9    22.9    23.1    22.3    22.5    28.5    24.0

NO. OBSER.       48      47      47      47      47      47      46      45      43

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 8
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 1250 PPM           TRT#:  4         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      13      20      27      34      41      48      55      62      69      76      83      90
----------------------------------------------------------------------------------------------------------------------------------

  79    251   108.9   132.5   142.4   153.9   156.4   164.4   169.3   173.2   174.6   176.7   177.9   179.6   183.3
  79    252    90.7   118.0   130.7   141.3   144.2   154.3   156.2   161.7   164.3   164.1   166.4   168.5   173.1
  79    253   109.0   136.8   149.3   161.1   168.4   176.6   183.0   189.7   190.9   194.7   198.6   200.2   205.2
  79    254    93.9   127.0   139.7   153.8   160.0   168.5   175.3   185.3   184.7   187.9   189.7   191.2   196.1
  79    255   101.9   126.5   136.5   146.9   154.4   163.0   167.2   170.6   173.1   175.9   176.7   177.9   182.5
  80    256   102.9   130.6   141.5   152.3   161.1   171.0   172.8   176.0   178.2   178.3   182.3   183.9   185.2
  80    257   103.4   132.5   139.2   152.3   160.0   169.0   173.4   181.2   181.0   178.7   185.2   184.2   185.6
  80    258    98.3   124.6   135.6   146.3   152.2   160.6   164.0   170.5   170.2   170.6   172.9   177.9   178.8
  80    259    83.3   109.3   120.2   132.9   138.6   146.7   148.2   156.7   158.4   163.7   168.5   170.5   173.8
  80    260   103.2   108.8   136.6   146.4   153.2   163.0   166.7   176.5   174.9   172.2   177.0   175.9   177.3
  81    261   103.3   132.0   141.9   154.8   156.1   161.9   166.6   175.4   174.0   176.6   180.8   182.6   185.6
  81    262   103.6   130.0   138.3   152.1   152.5   160.8   162.8   170.1   170.4   168.2   170.9   173.5   179.3
  81    263   102.1   128.2   138.8   150.5   159.4   171.6   176.0   183.6   184.9   187.5   190.4   192.5   194.3
  81    264    98.1   116.1   137.2   146.1   152.8   162.7   167.7   173.9   175.8   176.6   178.8   179.0   178.7
  81    265    86.2   113.9   128.1   140.8   145.2   152.2   157.6   165.6   168.3   168.5   170.4   174.9   174.1
  82    266   106.6   136.0   150.3   162.1   173.0   180.0   184.0   190.3   192.7   194.0   195.6   198.3   196.8
  82    267    99.0   120.8   133.7   144.4   151.6   158.0   163.8   169.5   175.1   177.6   181.2   179.6   179.4
  82    268   107.8   133.4   142.9   152.6   161.7   169.8   171.8   174.9   177.7   176.1   175.2   179.1   186.7
  82    269    94.7   124.5   135.8   145.1   154.3   156.2   162.1   167.4   173.7   179.0   177.2   183.9   187.1
  82    270    94.9   121.0   135.6   146.1   154.7   163.3   169.0   173.6   179.3   182.7   185.9   191.0   190.3
  83    271    94.9   129.1   140.7   152.7   157.7   165.4   171.7   180.1   182.7   184.8   187.4   192.6   194.2
  83    272    95.0   127.9   142.2   154.0   161.4   170.1   175.0   185.7   186.7   187.7   187.4   192.6   194.3
  83    273   105.1   130.9   145.0   155.5   159.6   163.4   168.1   174.5   175.3   176.4   178.4   177.9   182.0
  83    274    98.6   124.1   140.4   147.0   149.6   154.9   156.2   165.7   167.8   168.5   170.2   177.2   178.2
  83    275    88.9   122.0   140.7   153.7   158.7   168.0   172.2   184.1   187.2   187.9   188.5   189.0   194.4
  84    276    99.6   122.6   131.6   144.0   149.0   153.4   157.2   162.8   162.8   165.2   168.1   170.7   173.1
  84    277   106.5   125.4   135.8   145.5   151.1   158.5   159.5   162.9   162.0   164.4   168.7   171.9   172.5
  84    278    85.0   120.1   136.5   151.2   156.5   163.9   168.8   176.3   174.1   178.0   181.2   184.2   187.7
  84    279    87.7   112.7   121.9   135.8   141.3   148.1   153.7   158.8   157.8   160.5   164.6   163.5   167.6
  84    280    84.6   113.6   127.8   142.4   149.5   158.4   163.3   169.7   168.6   173.6   177.8   178.7   180.8
  85    281    83.1   113.3   126.2   139.2   147.8   152.5   156.7   160.4   161.4   165.2   170.0   168.7   171.4
  85    282    91.7   118.2   129.1   144.4   150.1   155.6   154.6   160.3   160.9   163.5   168.7   166.0   168.9
  85    283   108.8   130.7   142.5   152.5   160.7   168.1   174.3   179.8   186.5   191.2   192.6   195.1   196.5
  85    284    98.9   124.2   136.8   150.7   156.9   164.1   167.8   175.7   177.8   178.0   184.7   182.5   184.6
  85    285    95.3   120.6   132.0   146.3   150.4   158.2   165.5   169.9   171.0   174.0   175.6   175.4   177.3
  86    286   100.8   126.2   136.9   140.8   162.6   168.7   171.6   178.7   176.9   178.5   179.7   178.9   180.0
  86    287   102.2   126.5   140.2   152.0   169.4   172.2   176.2   178.1   177.5   179.5   181.3   179.3   182.6
  86    288   104.6   128.1   135.8   141.7   147.4   151.1   155.0   162.9   159.5   164.5   168.0   168.9   170.1
  86    289    95.9   125.2   139.4   153.9   164.2   169.6   175.7   180.2   180.6   183.5   185.8   183.6   184.3
  86    290    87.5   113.8   121.7   134.7   144.0   149.4   149.3   154.1   154.5   158.5   163.4   161.6   161.3
  87    291   101.1   118.4   133.2   142.7   149.5   156.4   160.8   165.7   167.4   171.7   174.2   178.1   181.3
  87    292    91.5   118.3   134.4   144.8   147.7   152.3   156.4   161.5   164.6   165.2   172.3   174.0   174.2
  87    293   106.5   134.0   147.2   153.1   162.0   169.5   174.0   182.2   183.2   185.7   188.2   186.8   188.8
  87    294    99.4   124.7   138.5   149.3   155.0   160.3   163.6   168.1   168.3   169.4   171.4   173.7   177.1
  87    295    94.9   124.2   148.6   150.0   159.6   162.8   164.6   167.5   171.0   173.9   177.4   177.8   181.0
  88    296   101.2   128.3   141.5   152.0   159.2   165.6   171.2   177.9   177.9   181.2   183.9   182.4   185.3
  88    297   109.2   136.4   147.4   159.1   163.8   168.8   174.9   182.4   179.4   184.4   186.2   185.1   187.8

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 9
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 1250 PPM           TRT#:  4         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      13      20      27      34      41      48      55      62      69      76      83      90
----------------------------------------------------------------------------------------------------------------------------------

  88    298    85.9   109.6   121.5   132.0   135.2   142.0   146.4   152.6   151.0   155.5   154.8   159.5   162.7
  88    299   105.3   132.1   144.0   155.1   161.5   169.8   173.8   181.4   179.2   180.8   184.0   181.8   188.2
  88    300    95.9   125.4   135.8   146.4   151.4   159.8   166.0   174.1   174.9   177.1   181.2   180.0   185.2
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)     97.9   124.2   137.0   148.1   154.9   161.9   166.0   172.4   173.4   175.6   178.3   179.6   182.1

SD              7.5     7.4     7.2     6.8     7.7     8.0     8.7     9.2     9.5     9.3     9.0     9.0     9.2

NO. OBSER.       50      50      50      50      50      50      50      50      50      50      50      50      50

AVE. BODY WT
REL. TO CNTL   0.98    0.97    0.99    1.00    1.00    0.99    0.98    0.98    0.98    0.97    0.96    0.96    0.96
(TRT#:    2 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 10
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 1250 PPM           TRT#:  4         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       118     146     174     202     230     258     286     314     342     370     398     426     454
----------------------------------------------------------------------------------------------------------------------------------

  79    251   190.2   196.1   202.7   203.0   210.2   214.7   217.9   221.3   227.1   232.3   236.7   239.3   239.8
  79    252   178.6   183.2   192.7   195.2   202.7   207.1   207.9   211.5   215.5   215.5   220.5   228.3   230.6
  79    253   207.6   217.0   226.1   231.5   238.6   243.2   242.9   245.0   249.2   251.9   254.5   261.3   267.1
  79    254   208.1   211.8   226.6   231.2   236.1   248.3   253.1   262.7   263.9   268.4   269.4   279.5   283.1
  79    255   191.4   191.7   197.8   204.3   210.5   212.6   215.7   215.3   220.4   221.8   228.7   232.1   231.5
  80    256   191.2   194.7   204.0   204.9   209.9   210.6   213.5   215.5   215.6   222.7   220.6 @
  80    257   191.8   193.7   203.6   208.8   211.1   216.1   216.6   222.3   220.5   220.3   224.3   231.2   229.0 @
  80    258   183.5   184.7   193.2   196.5   207.3   211.0   206.2   216.3   214.7   219.2   221.9   233.8   243.2
  80    259   179.4   183.8   194.1   199.3   208.2   213.7   208.5   216.2   219.6   221.3   229.8   230.8   236.9
  80    260   186.2   187.3   196.8   201.5   210.1   215.5   212.4   216.7   218.1   224.6   220.8   222.3   224.7
  81    261   197.9   202.7   205.8   214.8   218.9   221.7   223.4   226.1   228.0   233.4   233.7   236.3   244.1
  81    262   185.7   190.5   193.7   208.0   213.3   215.1   217.1   220.0   224.4   229.7   231.4   241.4   240.1
  81    263   196.2   206.0   211.8   218.7   233.4   230.2   232.5   235.9   231.8   236.9   237.4   247.6   249.8
  81    264   182.6   188.7   194.6   204.7   208.8   209.5   211.6   213.8   217.9   222.2   221.7   228.5   230.7
  81    265   185.2   191.3   198.0   208.2   215.8   216.1   221.7   223.7   226.5   236.5   240.4   252.1   264.8
  82    266   204.8   209.0   217.7   227.2   233.8   242.4   245.2   251.9   259.6   258.6   264.4   274.5   278.9
  82    267   185.8   190.6   199.7   200.8   205.6   214.0   216.1   219.2   225.9   223.9   225.8   229.1   240.5
  82    268   186.3   194.6   200.1   206.5   211.8   221.8   222.4   225.5   228.2   227.8   231.8   237.3   244.0
  82    269   191.3   192.4   199.1   205.5   205.8   217.8   214.6   213.9   220.5   221.2   227.9   228.6   240.6
  82    270   190.1   195.5   203.9   206.7   213.5   219.3   222.9   230.1   234.7   235.8   232.7   233.6   239.3
  83    271   200.9   206.0   217.5   222.9   228.1   233.9   236.9   241.1   248.4   254.3   258.6   254.9   265.6
  83    272   203.1   210.2   220.4   227.8   234.5   243.5   244.5   254.9   260.3   262.3   263.8   271.1   276.4
  83    273   187.3   195.4   204.6   212.4   217.9   221.9   222.5   230.0   227.2   235.7   241.3   241.3   246.6
  83    274   187.5   196.6   202.8   209.7   211.4   212.2   216.6   223.7   225.2   222.7   234.1   232.2   234.9
  83    275   199.8   208.0   213.4   220.2   229.1   234.4   236.1   243.7   244.1   248.9   254.5   250.5   255.1
  84    276   181.2   184.2   191.3   196.3   209.8   206.7   211.9   212.0   215.4   222.5   220.4   208.6 @
  84    277   181.5   189.0   197.5   201.0   208.5   208.5   215.6   215.9   221.1   227.6   228.4   232.3   240.3
  84    278   190.9   197.5   205.8   210.6   220.9   217.1   222.0   226.3   228.4   232.3   234.2   240.0   241.2
  84    279   172.3   179.8   186.8   193.8   205.3   207.7   206.9   208.9   212.1   220.7   217.7   223.5   229.4
  84    280   190.1   195.8   199.9   210.1   215.6   216.6   219.9   224.7   222.0   229.6   230.6   234.7   240.2
  85    281   177.9   184.0   193.0   195.5   197.5   200.1   200.6   198.8   204.6   213.5   212.9   216.5   215.0
  85    282   174.0   181.7   186.2   187.9   190.1   191.5   192.3   191.3   195.5   198.8   204.6   207.2   204.6
  85    283   198.7   203.1   211.7   221.9   226.2   234.9   235.7   236.7   237.0   243.4   244.1   249.3   253.4
  85    284   191.5   199.6   206.0   208.7   215.4   219.3   222.5   226.4   230.2   234.3   233.6   237.6   244.5
  85    285   183.9   189.5   195.4   202.3   206.4   208.5   211.6   211.7   217.8   225.9   230.4   232.6   236.2
  86    286   191.0   199.7   206.3   216.5   221.7   225.3   228.1   233.9   241.4   253.3   248.4   255.9   260.5
  86    287   191.2   197.7   200.4   207.5   214.0   214.9   215.1   216.7   224.5   232.1   229.7   232.1   227.8
  86    288   177.3   177.2   190.7   192.6   195.3   194.6   202.3   195.2   196.1   202.5   207.6   211.7   218.2
  86    289   196.3   208.0   220.6   225.1   228.3   226.5   232.7   236.4   240.4   243.0   238.3   242.7   250.3
  86    290   167.6   175.9   186.1   191.0   194.3   197.3   196.5   205.9   201.0   211.0   214.7   218.8   220.1
  87    291   190.2   199.6   205.7   214.2   219.5   227.6   232.5   235.5   242.5   247.5   254.2   262.8   268.1
  87    292   184.0   187.7   199.3   205.4   208.4   213.6   215.6   210.7   222.6   228.9   229.1   239.3   244.2
  87    293   198.4   201.1   211.7   219.7   221.6   230.5   232.1   231.2   239.8   243.8   245.9   250.8   249.3
  87    294   184.5   189.1   201.9   211.7   219.0   221.9   232.1   239.6   245.3   252.2   257.3   262.3   264.0
  87    295   189.4   195.4   203.9   215.5   216.0   222.9   224.2   226.9   235.7   242.4   243.8   254.2   254.9
  88    296   194.7   197.1   205.6   214.5   225.4   224.5   225.1   225.1   237.5   243.5   243.8   247.2   262.6
  88    297   193.2   198.4   202.4   211.9   218.1   217.0   220.9   218.3   223.7   225.3   228.8   233.2   234.1

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 11
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 1250 PPM           TRT#:  4         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       118     146     174     202     230     258     286     314     342     370     398     426     454
----------------------------------------------------------------------------------------------------------------------------------

  88    298   168.6   175.2   180.2   189.3   197.7   196.1   198.4   199.3   203.1   207.4   211.1   215.9   221.6
  88    299   191.0   197.8   205.9   213.5   221.6   218.2   219.5   218.7   226.4   228.5   226.3   237.3   241.5
  88    300   191.5   195.4   203.1   215.1   223.1   225.9   222.7   225.1   233.0   235.3   241.5   245.5   249.0
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    188.9   194.4   202.4   208.8   214.9   218.3   220.3   223.4   227.3   231.9   234.1   239.0   243.9

SD              9.1     9.5    10.0    10.8    11.1    12.5    12.9    14.6    15.2    15.0    14.9    16.2    16.9

NO. OBSER.       50      50      50      50      50      50      50      50      50      50      50      49      48

AVE. BODY WT
REL. TO CNTL   0.97    0.95    0.96    0.96    0.96    0.96    0.97    0.94    0.94    0.93    0.92    0.88    0.89
(TRT#:    2 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 12
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 1250 PPM           TRT#:  4         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       482     510     538     566     594     622     650     678     706
----------------------------------------------------------------------------------------------------------------------------------

  79    251   242.8   240.3   248.4   254.8   248.6   251.9   260.1   260.6   259.1
  79    252   232.5   232.0   235.5   238.8   234.3   238.5   246.6   252.0   246.5
  79    253   268.9   274.1   276.2   280.5   280.1   287.1   291.4   294.2   299.1
  79    254   288.4   289.5   291.3   291.8   294.9   302.9   305.9   309.7   322.5
  79    255   237.1   233.1   235.2   240.0   231.4   230.3   230.5   225.4   236.4 @
  80    256
  80    257
  80    258   245.8   251.9   258.1   260.3   246.7   205.6   190.6 @
  80    259   245.2   238.5   249.4   253.3   259.2   266.8   273.5   283.5   282.5
  80    260   226.5   234.0   244.0   246.1   249.6   249.4   255.2   256.0   257.0
  81    261   246.0   244.5   250.4   258.7   263.8   266.5   274.3   276.8   280.0
  81    262   240.8   246.7   248.7   252.9   258.8   260.3   267.6   271.3   275.0
  81    263   254.4   249.1   252.5   252.7   252.5   260.0   266.4   264.1   267.2
  81    264   229.7   226.3   230.8   239.6   233.6   237.4   243.8   239.7   248.1
  81    265   269.0   270.0   278.9   288.2   295.5   279.4 @
  82    266   279.2   276.4   280.1   278.4   281.2   285.8   295.0   304.7   297.7
  82    267   248.1   250.5   246.4   242.6   244.1   240.4   244.6   250.3   244.9
  82    268   246.3   243.7   249.9   251.7   250.3   254.5   257.4   263.0   253.8
  82    269   239.3   242.2   235.7   237.6   234.2   224.6   209.9   205.8   189.0
  82    270   224.3   192.6 @
  83    271   265.8   267.1   273.9   275.0   271.8   276.9   278.0   283.7   287.2
  83    272   276.9   282.5   294.0   292.0   294.1   298.5   300.7   305.3   306.3
  83    273   246.2   247.0   257.4   260.3   261.2   261.5   265.2   269.0   269.5
  83    274   231.0   232.7   246.9   241.2   235.4   239.4   241.7   252.3   246.1
  83    275   250.2   252.8   265.8   259.9   259.0   261.1   264.7   272.6   269.4
  84    276
  84    277   278.5   238.4   243.9   239.7   248.8   250.5   251.4   253.7   262.8
  84    278   245.6   240.8   250.9   247.6   256.2   261.1   264.7   263.4   267.6
  84    279   232.4   235.6   241.7   242.1   252.8   255.1   256.3   254.1   252.1
  84    280   243.7   248.5   251.4   249.6   256.7   258.7   261.4   261.1   266.6
  85    281   219.0   223.3   233.1   232.6   238.9   236.7   220.7   248.2   249.2
  85    282   209.0   210.6   214.7   215.1   218.7   222.0   228.5   238.0   239.8
  85    283   258.1   257.8   266.1   265.6   269.3   252.6   268.0 @
  85    284   248.2   252.9   263.3   264.7   269.4   277.1   294.5   326.7 @
  85    285   238.0   246.6   245.4   244.0   245.6   243.9   251.6   257.8   255.1
  86    286   266.2   267.6   267.9   262.3   262.7   268.0   271.1   277.6   283.5
  86    287   232.5   235.7   234.5   238.0   242.8   240.4   242.2   246.2   247.7
  86    288   220.8   219.9   219.9   223.4   225.4   222.6   226.6   223.1   229.4
  86    289   264.0   264.8   260.7   268.9   283.3   270.0   252.0   240.0   236.3
  86    290   226.4   232.1   235.5   240.1   239.1   241.1   242.9   246.3   251.3
  87    291   266.4   276.4   280.4   284.3   293.9   296.7   304.6   303.0   279.8
  87    292   263.9   273.2   279.5   284.3   282.9   290.8   290.1   284.4 @
  87    293   251.4   257.8   260.6   259.0   260.7   263.6   272.3   274.9   282.5
  87    294   268.1   272.1   278.6   280.7   279.6   283.6   289.7   296.7   301.0
  87    295   255.0   239.6   253.4   244.9   248.1   255.9   261.3   260.9   261.2
  88    296   269.8   277.1   280.5   288.5   292.0   284.0   230.1 @
  88    297   234.9   240.6   243.9   240.1   245.4   245.3   252.4   249.9   258.0

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 13
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 1250 PPM           TRT#:  4         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       482     510     538     566     594     622     650     678     706
----------------------------------------------------------------------------------------------------------------------------------

  88    298   227.5   234.0   232.4   228.0   234.5   244.6   246.9   248.9   245.3
  88    299   243.6   250.4   254.6   252.8   254.5   255.4   252.5   251.9   257.1
  88    300   248.0   259.4   261.4   262.3   264.1   265.3   270.2   273.1   277.0
              -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    247.8   248.4   254.4   255.5   257.5   257.9   259.2   264.8   263.5

SD             17.9    19.6    18.4    19.0    20.0    21.8    24.8    24.9    24.3

NO. OBSER.       47      47      46      46      46      46      45      42      40

AVE. BODY WT
REL. TO CNTL   0.89    0.87    0.88    0.86    0.87    0.86    0.85    0.88    0.85
(TRT#:    2 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 14
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 2500 PPM           TRT#:  6         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      13      20      27      34      41      48      55      62      69      76      83      90
----------------------------------------------------------------------------------------------------------------------------------

  89    301    97.6   114.8   130.5   140.7   151.9   161.2   165.0   172.7   179.4   180.6   181.8   184.0   183.1
  89    302   108.7   125.3   138.4   146.9   159.0   169.1   175.2   180.5   183.3   185.5   189.2   191.7   192.6
  89    303    86.4   110.7   124.5   138.5   148.8   155.7   159.6   168.2   171.4   179.1   183.3   184.4   186.0
  89    304   103.9   124.3   138.1   144.7   157.3   163.8   166.6   173.9   178.0   181.0   180.2   186.4   184.8
  89    305   105.2   120.5   134.1   140.8   154.3   159.9   167.4   174.8   175.7   178.0   180.3   175.3   176.8
  90    306   106.4   126.1   139.9   152.8   162.7   167.8   174.0   178.1   180.8   186.2   189.7   193.0   190.3
  90    307    98.6   116.0   131.2   142.5   153.0   162.0   167.5   171.1   175.0   178.2   180.1   182.2   181.0
  90    308    83.3   102.7   117.7   126.4   131.9   137.9   132.9   127.8   148.8   167.6   171.8   175.3   175.0
  90    309    87.9   106.3   122.2   131.8   142.3   150.8   155.3   158.2   163.2   168.6   169.9   166.8   171.3
  90    310   101.0   122.7   140.0   151.0   165.3   175.6   183.3   190.4   191.3   197.1   198.5   202.5   199.0
  91    311   109.9   128.9   142.3   151.5   159.0   166.7   169.0   174.7   178.7   181.4   185.2   184.3   186.6
  91    312    90.6   110.2   123.4   134.4   145.1   152.2   157.3   161.1   166.6   170.5   175.3   175.7   173.1
  91    313   107.4   126.1   137.7   146.2   151.8   161.6   167.1   169.6   174.0   175.0   178.3   177.9   178.8
  91    314   102.9   119.3   134.2   144.1   151.4   161.8   162.2   168.4   176.2   176.3   181.8   183.0   182.9
  91    315    90.6   108.2   122.4   134.8   143.9   153.1   160.2   164.9   168.7   172.8   175.7   174.6   176.3
  92    316   103.8   124.8   140.7   151.0   160.4   171.1   175.1   178.3   181.7   184.1   186.9   189.0   188.9
  92    317    99.4   118.2   131.9   144.8   151.8   161.5   165.6   170.7   172.8   173.4   174.7   176.4   176.5
  92    318    93.8   114.8   130.0   140.5   152.2   166.5   171.4   176.2   178.6   182.2   184.8   187.4   189.3
  92    319   108.1   126.1   139.2   150.4   159.0   163.2   169.2   174.5   177.9   182.4   183.2   182.9   182.4
  92    320   110.1   127.3   142.1   154.5   163.6   173.8   176.5   181.0   185.8   187.8   189.4   189.8   189.8
  93    321    90.9   112.9   125.2   135.1   141.8   149.7   154.0   161.8   165.2   170.3   170.9   173.8   173.7
  93    322   112.3   130.3   145.8   157.4   164.9   171.5   177.6   183.2   186.5   189.1   184.5   190.8   191.6
  93    323   107.3   123.6   140.1   150.9   162.5   172.2   175.1   182.6   183.1   187.7   186.5   188.9   188.9
  93    324   101.6   118.6   138.0   147.8   154.1   166.3   171.3   176.5   179.4   182.5   182.8   187.0   188.0
  93    325    95.2   108.5   125.4   137.7   147.3   157.7   164.2   171.0   171.9   174.3   176.6   174.2   175.6
  94    326   105.4   124.8   140.6   150.8   156.9   165.7   172.9   181.3   181.9   184.4   184.4   184.7   188.0
  94    327    94.7   121.8   137.9   150.4   160.8   170.8   180.1   187.1   190.2   189.3   191.2   195.0   194.0
  94    328   102.8   120.5   134.2   145.7   152.6   163.5   168.7   176.0   176.6   179.8   179.1   180.6   178.5
  94    329   108.3   124.8   137.7   150.6   158.9   167.7   173.4   182.5   183.3   185.6   187.3   187.9   188.3
  94    330    86.4   110.5   126.6   139.4   149.3   157.5   161.0   168.9   170.2   174.1   174.4   174.6   175.2
  95    331    98.1   118.3   135.4   144.3   156.1   166.5   175.6   182.2   182.8   183.7   183.9   180.6   181.8
  95    332   102.3   118.5   135.7   148.6   158.7   164.9   174.5   180.6   184.5   186.3   190.1   187.6   189.2
  95    333   103.7   118.2   131.5   140.4   147.3   155.8   163.2   166.2   163.6   164.9   164.8   164.7   166.2
  95    334    95.7   113.4   128.1   137.9   147.4   158.1   166.6   172.3   174.0   176.8   177.9   175.8   173.5
  95    335   102.7   119.0   132.9   143.7   150.9   161.1   168.6   179.2   176.7   179.4   179.6   176.3   176.4
  96    336   102.6   129.6   144.3   158.0   164.9   175.3   180.4   184.0   187.0   193.3   196.6   196.6   198.2
  96    337   108.1   127.5   143.4   154.6   164.4   171.5   179.4   185.5   189.3   192.2   193.8   195.5   197.1
  96    338   103.0   120.2   135.4   145.0   150.4   160.0   164.4   167.7   166.6   171.8   176.4   175.3   183.1
  96    339    86.2   105.6   120.9   133.8   140.7   149.0   154.3   162.6   161.4   164.8   168.7   165.8   168.0
  96    340    99.0   120.3   135.6   147.3   154.0   165.8   173.7   179.8   181.6   187.6   192.0   192.1   193.4
  97    341    92.9   112.1   128.1   141.4   150.5   159.3   166.1   172.4   172.7   177.5   177.1   175.9   175.0
  97    342   111.9   129.2   140.9   150.3   158.8   166.1   168.8   174.1   178.6   182.2   182.3   180.0   180.6
  97    343    99.9   120.4   134.8   148.0   161.0   167.7   174.2   178.7   181.5   186.1   185.1   186.4   187.3
  97    344   108.6   127.6   139.0   148.5   157.5   165.4   172.4   179.3   180.2   184.7   183.7   184.2   183.7
  97    345    93.0   118.0   133.6   148.5   159.2   168.2   173.2   180.6   185.1   189.1   190.0   189.3   190.4
  98    346   102.8   119.5   135.7   146.7   153.3   165.0   170.3   177.8   181.8   185.5   187.1   187.7   190.0
  98    347   104.5   120.1   134.7   142.6   152.1   158.7   163.5   167.3   168.7   169.5   175.8   174.4   172.9

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 15
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 2500 PPM           TRT#:  6         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      13      20      27      34      41      48      55      62      69      76      83      90
----------------------------------------------------------------------------------------------------------------------------------

  98    348    88.2   107.1   118.6   129.5   134.9   143.1   146.1   150.0   152.7   154.7   154.0   156.3   159.0
  98    349    90.8   104.6   111.0   118.5   119.3   126.9   129.9   128.7   126.8   129.8   128.7   126.4   122.3 @
  98    350    81.2    96.0   106.3   115.0   121.4   128.4   129.4   134.7   139.6   143.4   147.7   152.0   156.5
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)     99.5   118.3   132.8   143.5   152.3   161.1   166.3   171.8   174.6   178.2   179.9   180.5   181.0

SD              8.1     8.0     8.5     8.9    10.0    10.4    11.8    13.2    12.4    12.0    12.0    12.6    12.6

NO. OBSER.       50      50      50      50      50      50      50      50      50      50      50      50      50

AVE. BODY WT
REL. TO CNTL   0.99    0.93    0.96    0.97    0.98    0.99    0.99    0.98    0.99    0.98    0.97    0.97    0.95
(TRT#:    2 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 16
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 2500 PPM           TRT#:  6         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       118     146     174     202     230     258     286     314     342     370     398     426     454
----------------------------------------------------------------------------------------------------------------------------------

  89    301   190.7   197.0   202.2   201.8   208.4   211.2   211.2   216.3   215.2   213.1   216.8   216.4   220.1
  89    302   199.3   204.5   211.9   215.1   221.8   222.0   228.3   231.7   237.9   240.1   243.2   241.8   248.7
  89    303   191.0   194.4   203.3   204.9   212.7   212.9   215.4   218.3   219.6   222.1   219.2   222.2   234.1
  89    304   195.0   192.0   200.0   206.2   208.7   215.9   215.6   214.6   220.4   223.9   222.1   221.2   226.3
  89    305   188.9   186.1   198.9   203.2   205.0   214.3   212.7   217.8   225.5   225.6   228.6   230.6   236.4
  90    306   196.3   205.0   207.1   207.3   215.6   220.6   225.1   228.8   227.1   228.6   227.3   236.8   238.0
  90    307   187.4   190.1   197.6   201.9   211.9   219.6   219.1   223.8   222.2   224.5   225.9   227.5   229.4
  90    308   178.0   174.1   187.5   197.0   149.8   204.8   205.3   200.3   203.3   208.7 @
  90    309   174.7   181.3   189.2   191.5   201.4   202.1   205.2   208.1   208.6   208.8   211.7   217.2   221.4
  90    310   205.3   212.5   219.9   225.4   237.4   239.3   243.9   245.1   250.8   251.3   250.0   254.5   262.7
  91    311   191.3   193.5   198.1   205.1   212.1   208.8   214.2   212.1   219.7   218.3   218.6   222.1   225.1
  91    312   179.9   180.2   191.5   198.8   203.5   206.8   208.7   211.7   214.2   212.6   214.0   217.4   222.5
  91    313   186.5   193.0   206.4   210.0   222.4   219.2   230.1   229.5   230.9   233.4   236.2   240.0   245.9
  91    314   187.3   188.1   199.1   203.2   207.9   210.2   216.6   215.2   219.1   222.4   216.5   219.4   228.1
  91    315   182.6   186.1   194.7   199.9   205.8   208.6   210.8   211.1   214.3   214.1   214.1   218.5   226.0
  92    316   204.6   205.3   214.8   217.6   224.2   227.4   234.2   231.9   233.4   239.5   237.4   240.2   248.1
  92    317   207.9   193.1   198.3   200.5   203.6   204.6   202.9   205.0   208.2   207.8   202.7   206.0   207.0
  92    318   206.7   206.7   210.2   216.8   219.7   226.2   228.7   229.7   231.4   235.5   237.4   240.8   239.1
  92    319   199.7   207.0   205.2   210.5   214.6   217.5   225.2   225.7   229.0   234.9   228.4   230.0   235.8
  92    320   207.2   198.2   209.6   216.7   218.3   217.8   224.6   221.8   228.4   223.6   227.6   226.4   233.3
  93    321   181.6   188.6   197.2   204.2   210.2   213.2   218.6   216.0   220.6   224.1   227.9   234.1   235.7
  93    322   199.9   206.3   212.2   215.3   224.1   225.6   225.5   220.5   226.4   233.1   234.1   242.3   248.1
  93    323   196.3   199.0   204.9   211.9   219.6   217.9   224.5   215.6   226.2   226.0   225.5   230.1   230.0
  93    324   190.7   196.9   205.4   202.6   210.8   211.3   215.7   217.0   222.6   225.3   216.4   222.1   223.1
  93    325   185.0   188.1   198.9   203.0   209.2   207.6   206.4   210.8   212.6   215.8   217.1   221.0   224.6
  94    326   193.3   191.0   204.9   203.8   206.6   211.3   208.4   211.8   215.8   222.1   223.0   218.6   223.9
  94    327   195.8   205.4   216.5   220.0   221.5   226.9   229.2   231.9   237.8   241.6   241.1   241.4   244.1
  94    328   181.4   185.4   195.9   199.3   196.1   203.8   202.9   208.4   212.4   213.8   211.3   219.3   219.8
  94    329   188.9   195.0   207.1   206.4   209.5   214.5   210.1   209.3   211.3   217.9   222.2   226.1   228.1
  94    330   179.3   183.5   196.8   197.6   198.2   204.0   204.5   207.1   207.7   217.2   213.8   215.0   221.8
  95    331   187.7   201.2   207.1   207.1   219.3   218.6   217.1   227.0   223.4   226.9   227.4   232.4   233.6
  95    332   192.8   202.4   213.0   210.8   219.2   221.7   216.2   225.3   227.1   228.9   229.2   230.0   235.1
  95    333   173.1   182.1   190.3   189.6   195.5   199.4   196.8   203.8   206.7   212.1   214.1   216.7   216.6
  95    334   184.7   193.9   194.4   198.7   205.5   206.3   206.7   214.8   214.7   219.2   217.6   217.6   220.8
  95    335   180.5   189.9   198.0   206.3   209.0   212.0   214.7   218.9   223.8   223.5   222.1   224.5   227.3
  96    336   203.9   210.6   213.1   189.3   222.3   226.8   228.0   226.8   236.7   238.7   240.0   241.4   239.1
  96    337   200.6   213.4   222.7   205.7   238.2   240.2   240.9   239.1   249.7   252.3   255.6   260.0   259.1
  96    338   184.2   193.6   199.2   183.6   214.7   215.1   216.0   210.7   214.3   216.9   221.5   220.7   220.5
  96    339   176.7   186.4   187.8   163.4   192.2   199.9   198.4   198.7   206.1   206.9   205.9   206.5   207.2
  96    340   193.2   204.1   209.8   181.3   224.4   224.9   227.6   221.9   232.5   233.5   235.0   232.3   235.9
  97    341   181.7   184.8   195.3   200.7   185.6   214.6   214.6   212.5   217.5   222.9   225.8   227.0   228.4
  97    342   181.6   187.5   200.6   204.3   204.7   216.0   213.5   221.1   223.7   231.2   232.7   237.9   242.9
  97    343   191.4   195.4   201.4   204.1   204.9   215.5   218.7   217.8   221.7   224.9   229.9   231.5   233.1
  97    344   185.3   188.6   196.0   200.5   188.8   213.2   214.3   217.0   222.7   211.9   221.0   220.8   223.4
  97    345   197.6   198.2   208.6   211.2   196.0   228.4   224.1   223.0   231.4   232.1   230.3   235.7   234.7
  98    346   191.9   197.0   208.1   218.3   226.5   230.3   231.9   235.6   238.2   239.9   237.9   248.5   250.1
  98    347   178.7   182.6   192.8   197.5   202.7   203.4   209.6   208.1   212.8   216.5   212.3   224.6   228.9

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 17
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 2500 PPM           TRT#:  6         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       118     146     174     202     230     258     286     314     342     370     398     426     454
----------------------------------------------------------------------------------------------------------------------------------

  98    348   160.3   163.0   177.5   185.7   192.6   188.8   192.6   191.6   194.0   192.3   194.1   200.7   205.7
  98    349
  98    350   159.8   167.3   175.3   181.6   187.8   190.7   193.3   192.3   197.6   197.4   196.4   204.1   210.9
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    188.9   193.3   201.6   202.8   209.0   214.5   216.3   217.4   221.4   223.5   224.1   227.3   230.8

SD             10.9    10.8     9.8    11.3    14.7    10.7    11.5    11.2    11.9    12.3    12.6    12.5    12.5

NO. OBSER.       49      49      49      49      49      49      49      49      49      49      48      48      48

AVE. BODY WT
REL. TO CNTL   0.97    0.95    0.95    0.93    0.94    0.94    0.95    0.91    0.91    0.89    0.88    0.84    0.84
(TRT#:    2 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 18
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 2500 PPM           TRT#:  6         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       482     510     538     566     594     622     650     678     706
----------------------------------------------------------------------------------------------------------------------------------

  89    301   224.0   221.1   228.0   230.5   228.7   229.5   238.6   235.8   238.3
  89    302   249.9   246.7   252.8   257.9   259.6   232.2 @
  89    303   233.1   229.2   235.1   232.7   233.1   241.0   245.3   243.0   251.7
  89    304   225.2   225.5   226.4   229.3   230.2   239.1   239.3   244.3   251.4
  89    305   241.4   235.8   241.7   248.5   247.2   248.9   245.1   237.4   234.4
  90    306   240.6   242.7   248.4   257.8   262.6   258.3   272.1   266.2   275.1
  90    307   229.9   233.6   241.3   241.8   237.7   243.9   249.2   244.7   236.4
  90    308
  90    309   220.8   223.5   228.1   235.5   241.1   244.5   246.7   250.4   244.8
  90    310   266.3   265.7   273.2   272.2   273.8   274.6   285.0   294.3   296.3
  91    311   226.6   224.9   228.5   242.5   231.6   232.9   239.8   239.6   235.6
  91    312   226.2   224.6   229.8   231.1   246.0   242.0   248.2   251.2   250.4
  91    313   223.1   248.2   249.8   254.4   258.9   258.3   261.8   267.0   260.1
  91    314   228.2   225.1   227.5   232.2   239.1   235.5   223.7 @
  91    315   227.1   231.6   231.1 @
  92    316   257.3   238.3   240.1   205.6 @
  92    317   236.1   212.1   212.8   197.3 @
  92    318   206.2   256.0   260.5   264.5   270.2   274.6   281.2   280.9   282.1
  92    319   236.5   237.2   247.7   254.0   253.0   265.7   269.4   272.1   276.6
  92    320   233.4   232.1   233.2   233.1   231.9   238.7   251.5   249.4   255.6
  93    321   239.1   242.1   253.6   256.9   256.8   259.6   265.8   273.8   273.6
  93    322   246.5   227.1   231.0   254.8   257.3   265.4   271.2   277.2   246.7
  93    323   228.2   229.9   231.1   237.1   226.4   245.1   244.0   242.5   274.2
  93    324   220.4   223.8   226.2   227.6   236.3   234.0   240.1   246.9   254.7
  93    325   221.5   226.6   226.2   229.4   229.1   236.8   237.5   235.3   272.0
  94    326   224.5   225.8   224.7   229.0   227.6   227.3 @
  94    327   246.1   248.5   252.5   249.0   240.9   246.0   246.3   248.1   237.5
  94    328   214.0   222.9   219.5   162.1   205.2   222.4   157.9 @
  94    329   228.9   232.9   233.3   235.1   238.5   215.5 @
  94    330   220.5   223.8   228.7   229.7   232.1   244.7   251.0   251.0   267.1
  95    331   237.0   239.0   255.0   243.7   239.7   243.9   246.8   253.2   259.3
  95    332   235.4   238.3   255.0   242.2   239.5   241.1   246.6   243.8   223.0
  95    333   217.5   220.4   226.0   218.4   223.8   222.2   225.1   225.7   227.7
  95    334   221.0   224.0   241.1   232.1   225.4   234.8   234.7   241.4   240.2
  95    335   235.3   235.0   248.0   238.4   241.7   243.7   256.0   251.5   243.7
  96    336   245.0   246.8   245.1   246.1   252.3   253.5   258.9   256.8   258.6 @
  96    337   267.6   267.2   268.1   269.6   271.6   274.5   276.0   227.2 @
  96    338   224.9   226.4   226.7   228.3   231.8   229.8   230.9   232.4   228.8
  96    339   213.7   211.6   214.7   221.1   221.1   222.2   225.0   222.3   225.1
  96    340   243.6   244.2   239.9   246.8   249.2   248.7   254.5   259.2 @
  97    341   226.1   228.5   227.7   227.5   234.1   242.0   244.1   253.0   253.8
  97    342   244.1   243.2   250.6   251.1   259.2   270.8   275.2   292.2   302.8
  97    343   231.6   245.5   241.7   241.9   240.9 @
  97    344   227.9   229.4   228.4   239.2   232.7   238.0   233.1   237.5   233.8
  97    345   234.0   239.0   241.1   226.8   246.5   251.1   253.5   263.9   265.1
  98    346   252.2   258.2   263.2   261.0   273.9   275.4   278.6   276.3   277.2
  98    347   229.2   228.9   231.9 @

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 19
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 2500 PPM           TRT#:  6         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       482     510     538     566     594     622     650     678     706
----------------------------------------------------------------------------------------------------------------------------------

  98    348   201.9   201.9   206.0   211.0   213.8   214.0   218.9   200.4 @
  98    349
  98    350   209.3   209.7   213.9   216.2   210.9   210.9   217.9   214.6   212.1
              -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    231.6   233.2   237.2   236.8   241.0   243.6   247.2   250.1   253.3

SD             13.9    13.5    14.7    19.6    16.4    16.8    22.6    20.2    21.2

NO. OBSER.       48      48      48      46      44      43      40      38      35

AVE. BODY WT
REL. TO CNTL   0.83    0.82    0.82    0.80    0.81    0.81    0.81    0.83    0.81
(TRT#:    2 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 20
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 5000 PPM           TRT#:  8         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      13      20      27      34      41      48      55      62      69      76      83      90
----------------------------------------------------------------------------------------------------------------------------------

  99    351    92.6    91.6   110.3   122.7   134.9   144.1   152.7   158.9   161.7   159.4   162.3   165.2   170.2
  99    352    99.0    87.7    99.0   104.1   109.5   112.2   114.9   115.7   112.5   114.6   114.2   116.2   119.4
  99    353   103.7    98.1   106.5   113.0   121.1   123.9   131.0   135.1   135.9   137.0   136.6   138.7   142.4
  99    354   101.7    98.0   110.0   121.9   131.4   137.6   140.2   148.3   146.8   150.9   149.9   152.5   154.9
  99    355   104.8   108.4   124.5   133.4   141.4   149.5   156.6   162.2   164.9   168.4   169.0   170.3   172.8
 100    356    95.3    89.5    99.9   106.0   115.0   120.9   125.2   131.1   132.3   136.6   131.0   131.4   135.7
 100    357   108.4   105.6   121.8   133.1   141.9   149.5   154.6   158.4   159.2   164.4   163.3   166.1   170.0
 100    358    91.6    89.8   103.5   114.1   124.0   134.6   138.9   144.4   145.0   147.1   145.7   147.2   153.7
 100    359   105.0   103.8   115.7   125.6   137.4   146.4   153.6   158.3   157.0   159.4   157.8   159.1   160.9
 100    360   100.7   101.3   115.5   124.1   134.4   140.3   146.0   150.6   151.5   154.3   152.8   154.5   160.7
 101    361    99.4    99.5   114.1   119.4   127.1   130.8   131.7   131.5   132.2   135.1   134.6   137.4   142.4
 101    362    93.2    96.0   104.0   109.2   115.3   120.7   126.5   128.8   126.9   127.3   133.7   139.7   147.1
 101    363    82.6    82.3    93.5   101.4   105.3   107.3   109.7   113.5   111.1   112.2   112.8   117.6   121.1
 101    364    99.7   101.9   114.6   125.4   130.6   141.2   143.0   149.9   146.6   151.4   152.0   151.3   155.4
 101    365   107.0   106.6   117.1   125.2   133.4   141.6   145.1   153.9   153.6   154.7   156.9   160.0   163.1
 102    366   107.4   108.3   123.9   130.5   137.3   144.1   151.8   154.2   157.2   161.8   161.4   165.1   170.6
 102    367   101.3   106.8   117.7   125.3   133.5   141.8   143.1   145.7   152.0   154.8   156.7   158.8   161.6
 102    368   104.1   101.7   117.2   129.8   135.0   143.3   152.9   159.1   161.5   162.1   162.3   166.9   169.4
 102    369    97.8    95.1   114.0   123.0   136.5   147.1   151.4   156.3   161.0   164.6   165.7   168.1   171.5
 102    370    87.5    91.1   102.4   110.0   118.5   125.7   130.8   133.0   137.8   141.9   141.8   145.0   149.2
 103    371    82.6    79.0    92.4    99.1   105.4   108.1   112.9   116.8   117.0   117.9   118.0   118.0   123.9
 103    372   107.8   103.3   111.5   117.9   126.3   130.8   133.9   137.5   141.0   141.6   140.9   142.9   144.6
 103    373    95.7    90.1   108.3   119.5   131.5   137.1   141.2   149.6   149.7   154.7   153.7   155.9   155.8
 103    374   100.1    97.7   107.1   113.3   119.5   122.7   120.0   122.7   127.4   128.8   126.2   124.4   127.3
 103    375    88.9    83.8    94.8    98.7   105.1   110.1   112.7   113.6   118.4   121.1   119.9   117.1   118.8
 104    376    87.8    84.9   100.1   115.2   123.7   132.4   141.1   144.3   146.9   148.1   142.9   151.0   153.5
 104    377   103.3    94.3   113.4   126.6   133.5   141.4   149.8   160.0   160.6   166.4   164.6   168.5   174.9
 104    378   104.0   100.5   111.0   117.5   126.1   134.6   137.5   137.4   142.5   142.8   148.7   147.0   152.0
 104    379   110.6   104.2   117.7   127.3   137.7   143.6   150.6   156.0   157.8   160.7   161.2   159.5   160.3
 104    380    90.9    91.7   102.5   111.8   121.1   129.8   135.6   145.9   144.6   144.8   146.2   150.2   151.5
 105    381    97.0    82.8   113.4   121.7   130.7   139.5   146.2   149.0   154.2   152.4   154.6   154.5   159.9
 105    382   103.5   101.6   117.5   118.6   138.2   146.9   153.0   159.3   161.1   158.1   158.7   161.4   163.9
 105    383   103.3    95.5   102.6   109.5   119.0   123.1   126.4   133.3   136.8   138.2   140.8   146.0   151.1
 105    384    89.9    91.4   104.4   111.2   114.5   119.1   123.4   130.8   132.7   131.4   132.1   134.7   140.3
 105    385   102.1    99.5   115.6   126.0   132.7   141.7   145.1   150.8   154.2   154.7   157.4   157.4   162.1
 106    386   104.9   100.7   105.5   118.2   122.0   128.6   133.4   143.8   145.6   145.9   148.9   154.4   157.8
 106    387    92.3    92.7   107.3   121.6   131.8   139.3   146.9   154.3   153.3   158.5   156.8   161.5   161.9
 106    388   100.6    96.4   106.3   116.1   120.7   127.9   133.2   135.8   137.7   139.6   142.6   141.5   144.3
 106    389   104.5   100.6   114.3   124.8   132.4   137.8   141.6   135.3   141.2   147.1   157.2   154.7   154.8
 106    390    91.2    91.8   103.8   112.7   121.3   133.2   137.2   142.9   144.9   149.4   150.4   152.3   156.0
 107    391   103.5    94.6   106.4   114.8   120.5   130.2   133.4   139.8   143.0   147.3   148.0   152.1   155.3
 107    392   108.7   103.7   118.1   130.2   140.1   145.4   150.1   155.8   159.2   156.2   163.7   168.5   170.7
 107    393    96.9    88.3   103.7   109.0   113.0   115.1   114.5   116.0   117.2   121.4   124.9   128.1   127.6
 107    394    87.8    81.3    90.7    98.3   104.0   106.4   112.4   115.6   117.8   115.3   120.2   126.9   132.2
 107    395   101.3   102.4   115.3   114.4   116.6   117.2   119.2   123.5   126.1   125.4   130.9   133.8   133.2
 108    396    96.5    90.7   102.3   107.1   117.1   122.6   125.4   132.8   130.0   132.3   132.6   137.7   134.8
 108    397   110.6   105.4   122.8   134.3   140.5   150.1   150.3   156.1   159.5   163.4   162.8   167.4   168.6

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 21
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 5000 PPM           TRT#:  8         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      13      20      27      34      41      48      55      62      69      76      83      90
----------------------------------------------------------------------------------------------------------------------------------

 108    398   110.0   104.7   119.2   129.5   137.9   149.1   150.9   158.0   159.3   162.7   162.9   166.9   170.6
 108    399   101.4    99.9   118.2   131.2   139.8   148.7   154.9   162.9   163.4   165.6   164.1   169.0   169.4
 108    400    88.6    84.4    94.1   102.3   101.9   103.7   108.2   110.2   113.1   111.5   112.6   112.9   114.7
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)     99.0    96.0   109.3   117.9   125.8   132.4   136.8   141.6   143.3   145.2   146.1   148.5   151.7

SD              7.4     7.8     8.6     9.8    11.2    13.1    14.1    15.3    15.5    16.1    15.9    16.3    16.4

NO. OBSER.       50      50      50      50      50      50      50      50      50      50      50      50      50

AVE. BODY WT
REL. TO CNTL   0.99    0.75    0.79    0.79    0.81    0.81    0.81    0.80    0.81    0.80    0.79    0.80    0.80
(TRT#:    2 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 22
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 5000 PPM           TRT#:  8         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       118     146     174     202     230     258     286     314     342     370     398     426     454
----------------------------------------------------------------------------------------------------------------------------------

  99    351   175.4   176.9   181.3   186.9   190.6   191.5   194.4   194.2   202.1   205.5   213.8   216.0   213.0
  99    352   121.2   125.9   127.4   134.6   136.0   133.5   140.2   145.4   151.0   151.2   152.1   162.6   161.1
  99    353   142.9   185.6   145.5   147.2   159.2   154.6   156.5   157.0   167.3   169.3   176.7   188.9   190.0
  99    354   158.5   163.2   164.8   171.8   177.4   175.7   178.6   178.7   183.6   183.5   189.1   197.2   198.5
  99    355   177.1   146.9   189.5   190.8   199.4   194.4   195.1   197.2   199.4   202.0   210.5   218.3   218.4
 100    356   143.8   146.8   152.9   154.1   146.1   162.1   170.4   177.6   185.8   186.9   192.2   194.8   191.1
 100    357   175.8   182.4   186.8   189.7   173.5   191.9   196.7   199.9   203.2   205.8   212.2   219.6   214.0
 100    358   159.8   160.7   162.6   169.9   159.0   174.7   177.6   177.1   183.1   178.7   187.5   192.3   189.4
 100    359   165.2   173.2   177.0   180.6   175.9   186.3   187.8   192.5   197.9   193.9   197.2   204.0   197.4
 100    360   168.9   172.5   181.0   181.2   167.2   184.8   192.7   191.0   196.5   191.7   194.9   196.8   191.0
 101    361   145.8   146.9   160.7   167.9   177.5   184.9   188.2   193.7   203.7   205.7   208.9   210.9   216.1
 101    362   157.7   165.6   173.7   175.6   184.4   184.7   186.2   186.9   193.2   199.3   202.4   209.7   211.7
 101    363   126.5   128.7   134.1   136.1   133.4   135.2   132.6   110.4   155.0   169.2   164.4   161.0   164.2
 101    364   154.6   155.0   160.9   165.2   168.0   167.3   170.6   171.7 @
 101    365   167.5   169.8   175.6   180.1   185.4   185.3   185.4   185.5   189.7   188.8   188.9   195.2   193.6
 102    366   167.5   173.2   180.0   178.5   187.1   185.0   185.7   187.8   193.8   197.3   202.9   203.3   203.8
 102    367   160.0   166.2   177.6   173.3   184.7   183.5   183.4   184.9   190.3   189.3   196.9   201.2   200.8
 102    368   169.3   170.6   184.6   182.3   189.3   189.6   188.3   190.6   192.4   196.8   196.5   196.9   203.1
 102    369   172.6   177.2   183.0   181.2   190.2   188.7   189.6   191.8   190.7   192.7   194.7   197.7   200.0
 102    370   150.5   154.0   164.2   164.8   172.0   172.8   174.6   177.7   184.5   188.1   192.3   198.8   203.7
 103    371   120.8   123.5   128.4   136.6   143.8   142.8   146.6   146.3   153.0   160.5   165.8   176.3   181.6
 103    372   142.1   149.5   157.6   155.9   173.1   173.9   176.4   177.1   182.6   194.8   201.5   206.2   216.2
 103    373   155.4   162.1   168.0   173.3   178.3   175.6   181.8   182.7   182.1   188.9   194.6   199.6   198.6
 103    374   124.1   126.1   131.4   137.1   145.1   136.2   139.5   142.9   143.3   144.7   150.7   153.1   156.1
 103    375   121.1   126.7   136.3   132.2   144.9   134.1   141.7   148.5   148.9   158.5   160.6   168.3   175.0
 104    376   154.4   160.2   166.1   168.8   173.5   177.8   183.4   183.2   185.8   196.9   133.1   172.4   202.7
 104    377   174.0   181.8   182.9   187.9   192.9   195.8   196.0   196.7   191.6   198.7   192.3   198.7   199.4
 104    378   159.1   156.2   168.6   172.9   177.1   180.2   183.8   184.4   188.3   183.8   193.8   200.3   202.4
 104    379   161.3   163.6   165.8   174.6   185.1   191.2   195.3   193.2   188.8   199.4   189.6   198.2   193.1
 104    380   154.9   164.7   169.4   175.6   180.0   185.0   189.9   192.8   195.9   209.6   204.8   211.3   211.4
 105    381   164.1   163.0   168.1   173.6   178.4   181.2   184.2   186.4   193.8   188.7   194.7   198.0   194.9
 105    382   169.9   174.5   179.5   188.1   197.1   200.1   207.2   202.5   204.4   205.6   211.8   212.9   209.1
 105    383   159.1   163.8   167.2   171.2   176.3   178.5   181.6   183.1   181.8   188.4   187.2   194.4   194.5
 105    384   144.3   145.9   156.4   160.6   164.1   174.1   181.0   187.1   185.7   197.6   195.7   203.6   200.1
 105    385   164.4   163.6   171.6   171.4   176.4   182.0   184.0   190.6   189.8   191.9   197.9   204.7   206.8
 106    386   164.6   168.2   174.0   179.9   187.9   196.2   201.6   200.4   205.9   201.9   204.6   207.4   209.1
 106    387   166.7   164.6   174.0   177.7   183.2   181.3   182.7   186.2   188.6   195.4   190.1   200.2   202.4
 106    388   148.6   152.8   156.8   160.1   170.6   172.2   176.5   180.1   184.3   189.9   191.5   195.5   196.0
 106    389   156.9   159.8   168.8   166.1   175.8   180.5   183.6   193.2   199.6 @
 106    390   156.8   162.7   169.9   170.4   174.6   175.5   179.6   174.1   176.9   181.5   176.1   178.8   181.3
 107    391   154.6   157.9   164.2   164.3   168.2   167.3   172.2   170.9   172.5   172.8   167.1   181.5   186.7
 107    392   172.7   180.2   186.9   186.2   193.2   197.3   197.6   197.7   199.8   198.4   198.2   201.2   202.8
 107    393   122.5   127.4   141.8   141.7   149.5   153.0   161.4   169.1   169.4   173.6   180.5   184.9   189.9
 107    394   126.8   134.3   140.2   144.0   149.0   150.9   149.5   154.4   159.7   156.9   161.3   169.5   169.0
 107    395   130.8   128.3   129.3   129.7   134.5   134.9   142.1   143.0   150.4   163.8   165.6   169.8   172.1
 108    396   134.0   138.7   143.5   150.2   152.8   153.6   159.4   161.5   162.8   167.5   172.2   174.1   171.1
 108    397   173.3   171.7   178.6   180.3   185.9   187.7   189.8   191.0   194.5   201.1   198.8   200.1   201.0

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 23
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 5000 PPM           TRT#:  8         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       118     146     174     202     230     258     286     314     342     370     398     426     454
----------------------------------------------------------------------------------------------------------------------------------

 108    398   171.8   181.6   184.3   186.8   196.7   188.7   193.8   191.7   194.2   196.3   189.3   195.7   192.6
 108    399   169.6   173.9   177.8   180.8   187.4   185.6   190.9   192.8   193.8   194.6   187.9   189.0   188.1
 108    400   111.1   116.1   124.3   126.1   136.5   137.3   145.6   149.9   150.5   161.1   162.5   170.6   169.4
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    153.8   157.7   163.9   166.7   171.8   173.9   177.5   178.9   183.3   186.6   187.4   193.4   194.5

SD             17.7    18.1    18.1    17.9    18.1    19.1    18.5    19.2    17.0    16.1    18.0    15.9    15.2

NO. OBSER.       50      50      50      50      50      50      50      50      49      48      48      48      48

AVE. BODY WT
REL. TO CNTL   0.79    0.77    0.77    0.77    0.77    0.76    0.78    0.75    0.76    0.74    0.74    0.72    0.71
(TRT#:    2 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 24
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 5000 PPM           TRT#:  8         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       482     510     538     566     594     622     650     678     706
----------------------------------------------------------------------------------------------------------------------------------

  99    351   221.2   215.3   218.3   223.6   220.9   219.4   217.3   217.9   221.7
  99    352   166.6   169.3   172.1   174.5   169.3   168.5   189.0   163.3 @
  99    353   190.4   182.9   191.4   192.2   189.6   187.6   189.1   189.1   189.4 @
  99    354   202.4   202.5   206.1   202.8   203.3   203.9   212.3   211.0   213.8
  99    355   220.3   213.7   216.7   214.4   203.9   208.1   188.8   204.2   199.3
 100    356   195.4   196.2   201.8   201.3   199.5   200.3   202.4   207.6   209.2
 100    357   221.7   222.6   226.9   229.5   224.6   229.9   226.5   226.4   226.7
 100    358   198.7   200.8   201.9   205.7   206.5   208.4   205.9   205.8   207.0
 100    359   201.3   205.5   175.8 @
 100    360   197.1   198.4   205.7   210.5   209.0   215.0   212.5   212.8   211.3
 101    361   218.6   213.3   211.2   215.7   202.5   212.6   201.4   202.3   199.8
 101    362   213.6   204.6   209.3   208.1   205.4   210.2   206.6   205.4   203.8
 101    363   165.9   161.5   160.5   159.0   164.4   162.3   157.5 @
 101    364
 101    365   193.2   190.2   192.5   192.4   184.6   189.6   192.1   195.9   196.1
 102    366   206.0   210.5   225.3   225.6   219.8   226.5   224.6   234.4   230.6
 102    367   192.5   192.7   134.0 @
 102    368   196.1   202.5   209.2   213.6   202.7   218.5   215.6   223.0   225.9
 102    369   197.4   206.1   216.4   218.9   215.7   219.5   222.6   227.5   224.4
 102    370   195.2   191.3   208.2   205.2   205.1   209.8   211.2   216.9   212.3
 103    371   176.5   183.4   186.8   192.5   180.6   182.5   187.0   187.2   190.9
 103    372   205.3   209.5   215.0   220.9   218.9   225.8   223.7   221.1 @
 103    373   188.4   196.7   203.9   203.0   202.4   208.7   209.3   211.1   218.1
 103    374   151.7   165.2   165.8   172.8   160.3   168.5 @
 103    375   170.8   175.7   175.3   178.0   177.0   179.5   176.5   176.1   179.9
 104    376   198.7   201.6   214.7   219.9   215.7   211.9   222.1   202.9   207.3
 104    377   201.7   207.7   217.2   212.8   209.9   217.3   218.6   217.8   214.8
 104    378   194.5   201.5   204.2   199.9   193.3   200.8   204.1   215.3   200.4
 104    379   195.2   200.0   200.3   205.1   197.7   204.9   210.3   211.6   204.4 @
 104    380   206.6   216.1   188.6 @
 105    381   189.1   195.2   199.2   196.1   196.4   200.7   200.4   195.5   193.5
 105    382   206.2   210.6   215.3   214.0   213.9   213.6   217.4   216.9   216.1
 105    383   193.6   201.3   207.1   209.3   201.8   208.9   210.9   210.7   207.0
 105    384   197.5   194.1   205.5   198.7   193.3   189.7   197.1   192.9   188.4
 105    385   197.8   200.6   206.1   208.4   202.3   202.3   204.1   200.9   199.2
 106    386   205.7   210.1   205.1   205.0   205.2   203.9   207.0   166.7   163.0 @
 106    387   197.1   203.9   206.3   210.7   207.8   208.3   214.5   214.2   218.2
 106    388   193.2   198.0   196.6   201.9   201.1   194.0   196.6   198.5   196.5
 106    389
 106    390   176.2   180.7   186.1   188.4   187.7   193.6   199.1   198.2   196.9
 107    391   177.6   188.0   190.4   190.6   188.6   194.1   197.2   173.3   160.8 @
 107    392   193.7   203.2   206.8   206.3   212.0   220.4   216.9   219.6   217.1
 107    393   178.0   185.3   186.1   184.7   181.3   184.9   176.6 @
 107    394   161.3   163.7   169.8   173.3   165.1   166.1   169.4   171.7 @
 107    395   163.2   172.6   178.6   179.9   177.5   178.3   179.2   179.3   172.9
 108    396   176.3   170.1   172.8   176.2   177.9   176.7   182.8   179.4   174.8
 108    397   189.2   194.8   194.3   195.8   191.3   191.8   196.4   192.2   186.0

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 25
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: FEMALE   TRT: 5000 PPM           TRT#:  8         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       482     510     538     566     594     622     650     678     706
----------------------------------------------------------------------------------------------------------------------------------

 108    398   191.4   195.6   202.3   207.8   212.8   205.5   208.4   211.3   201.1
 108    399   186.9   193.4   196.5   201.2   207.6   215.2 @
 108    400   162.7   167.6   175.1   173.4   172.1   175.0 @
              -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    192.1   195.1   197.0   200.4   197.3   200.3   202.4   202.7   202.1

SD             16.3    15.1    18.6    16.2    16.4    17.4    16.0    17.6    17.2

NO. OBSER.       48      48      48      45      45      45      42      40      37

AVE. BODY WT
REL. TO CNTL   0.69    0.69    0.68    0.68    0.66    0.66    0.66    0.68    0.65
(TRT#:    2 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 26
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 0 PPM              TRT#:  1         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      12      19      26      33      40      47      54      61      68      75      82      89
----------------------------------------------------------------------------------------------------------------------------------

   1      1   140.9   198.6   234.9   264.3   279.3   294.9   308.5   328.7   337.5   350.1   353.1   363.9   367.3
   1      2   130.1   188.5   221.9   255.9   270.0   288.3   301.7   318.4   326.2   338.9   344.4   354.0   360.0
   1      3   115.5   171.3   200.6   232.5   247.5   265.3   276.3   295.9   300.1   316.0   319.9   333.5   334.0
   2      4   121.2   178.1   215.9   248.3   267.2   285.4   304.5   323.8   332.4   349.5   364.2   379.1   387.7
   2      5   134.0   194.7   223.0   253.6   268.1   284.9   302.5   325.9   330.9   345.4   356.0   367.7   368.8
   2      6   126.8   187.1   221.4   250.6   264.2   279.0   293.8   311.7   322.1   334.9   341.0   355.9   353.0
   3      7   105.7   160.2   196.7   234.5   249.8   267.5   277.3   303.9   312.0   328.4   331.1   342.0   345.1
   3      8   138.5   196.0   225.5   259.1   274.4   289.4   299.3   318.9   323.1   335.6   337.3   350.8   352.9
   3      9   120.4   173.5   207.0   239.1   248.9   267.3   280.9   297.1   311.6   324.3   328.6   344.0   345.6
   4     10   134.7   196.6   232.2   266.8   283.4   303.3   320.9   338.1   346.9   362.5   367.2   381.2   382.8
   4     11   129.8   188.8   220.5   257.5   272.0   290.9   306.4   327.8   335.4   349.0   363.4   374.8   379.6
   4     12   115.5   172.8   204.4   240.0   254.3   271.2   284.3   305.1   318.2   327.6   336.3   343.5   343.9
   5     13   121.9   172.4   199.4   224.9   242.3   259.2   271.8   286.8   295.2   306.2   311.1   322.2   322.0
   5     14   112.5   168.7   197.1   219.2   233.4   247.1   260.3   276.8   283.5   297.3   302.9   314.4   320.5
   5     15   119.3   174.7   204.4   234.8   248.5   265.5   279.5   294.2   300.2   312.3   321.8   330.8   331.8
   6     16   131.3   179.5   199.7   223.2   234.1   248.3   262.9   279.0   286.7   299.8   306.1   320.1   321.7
   6     17   115.3   166.1   190.9   217.8   229.8   244.6   260.2   278.4   281.6   295.9   305.2   319.4   320.3
   6     18   142.3   201.2   229.8   258.9   268.3   287.6   302.5   315.6   323.2   338.2   344.4   358.6   361.5
   7     19   131.4   190.7   224.4   256.4   266.2   285.7   304.3   323.9   329.3   339.6   345.7   359.6   364.9
   7     20   117.3   171.3   205.4   232.9   246.9   265.6   281.9   299.4   306.5   318.5   324.4   342.6   345.6
   7     21   129.2   184.8   215.3   247.1   259.0   276.4   290.0   312.6   315.9   330.7   337.2   348.4   346.3
   8     22   130.6   188.3   221.4   251.7   268.1   287.5   301.1   317.6   329.8   342.6   349.4   354.2   355.1
   8     23   131.1   166.0   211.8   243.4   259.7   276.4   285.5   302.1   308.3   315.6   316.8   324.0   329.6
   8     24   119.6   174.1   209.1   241.8   258.0   278.4   294.4   318.1   333.6   339.1   345.8   360.0   366.4
   9     25   130.1   190.9   220.8   248.3   264.8   241.0   288.8   314.0   323.9   333.9   336.7   352.5   349.9
   9     26   107.3   151.9   174.0   197.2   205.8   186.4   221.8   239.1   250.1   258.7   264.4   274.6   282.4
   9     27   121.6   182.7   219.1   250.6   268.3   246.8   289.9   312.8   322.5   329.8   338.4   353.0   363.3
  10     28   121.7   176.1   202.8   228.7   241.7   257.3   270.6   287.6   294.1   303.0   310.1   325.2   330.5
  10     29   117.1   169.3   196.9   223.0   236.2   256.5   272.8   292.8   300.2   312.2   317.2   332.8   335.5
  10     30   135.8   188.5   213.0   240.7   254.3   273.4   282.4   300.0   310.6   322.8   328.0   339.6   343.9
  11     31   124.1   183.5   216.0   248.8   257.5   276.1   286.9   311.9   320.9   329.8   331.3   342.2   349.4
  11     32   102.0   152.1   183.5   211.0   226.0   241.5   256.0   274.5   289.2   301.1   303.5   318.5   323.8
  11     33   133.6   188.8   216.2   244.6   255.0   271.8   288.7   302.1   315.5   329.1   332.3   347.7   351.4
  12     34   119.2   166.8   194.8   223.7   236.3   251.2   269.0   285.1   294.7   305.8   308.3   320.2   326.8
  12     35   113.8   169.4   202.2   234.2   249.3   266.4   285.3   303.5   316.2   331.6   341.0   342.3   347.8
  12     36   127.8   186.9   216.3   248.2   264.6   283.9   302.0   320.9   332.6   336.3   337.1   346.3   354.9
  13     37   126.8   187.8   217.4   249.1   268.7   283.8   300.8   319.0   328.4   331.3   326.8   339.8   344.7
  13     38   132.6   182.9   217.8   256.1   271.6   290.8   307.6   320.1   329.5   338.6   343.4   361.2   366.9
  13     39   123.2   177.1   200.0   228.1   243.9   258.7   272.6   286.7   293.5   300.8   306.8   321.8   322.4
  14     40   134.2   190.4   222.2   252.8   269.8   287.3   305.3   319.1   330.4   343.5   335.4   356.4   363.8
  14     41   125.8   184.9   209.2   242.6   260.0   274.8   287.3   300.7   312.1   318.2   320.3   328.4   331.8
  14     42   112.2   168.2   201.1   234.5   250.4   266.3   280.6   299.2   313.7   321.7   322.8   338.1   339.8
  15     43   118.1   179.3   214.5   247.6   262.3   283.8   300.8   317.6   333.0   340.7   348.2   356.7   362.1
  15     44   105.4   164.2   198.5   231.3   247.5   266.1   283.9   302.0   307.6   313.1   320.2   330.0   334.8
  15     45   134.0   187.4   212.3   238.2   254.5   268.3   285.1   301.4   313.0   320.8   325.7   335.5   338.0
  16     46   141.6   190.4   214.3   243.3   261.7   273.9   283.9   298.9   308.8   317.1   319.1   328.2   329.1
  16     47   124.8   180.3   211.8   243.9   259.6   273.7   285.5   300.7   307.1   316.4   325.7   334.3   339.4

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 27
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 0 PPM              TRT#:  1         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      12      19      26      33      40      47      54      61      68      75      82      89
----------------------------------------------------------------------------------------------------------------------------------

  16     48   125.9   174.0   201.4   232.7   248.5   259.8   276.1   296.2   306.3   318.3   325.6   338.5   344.4
  17     49   115.8   172.4   199.2   234.9   250.4   269.3   279.6   299.6   310.4   320.8   327.6   340.4   343.8
  17     50   118.3   170.4   202.4   231.3   248.5   267.5   282.4   302.8   311.5   320.8   328.9   335.7   338.5
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    124.2   179.2   209.8   240.4   255.0   269.7   285.9   304.2   313.3   324.3   329.6   341.7   345.3

SD              9.7    11.5    12.4    14.1    14.9    19.1    17.0    17.5    17.8    18.1    18.6    18.9    19.0

NO. OBSER.       50      50      50      50      50      50      50      50      50      50      50      50      50

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 28
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 0 PPM              TRT#:  1         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       117     145     173     201     229     257     285     313     341     369     397     425     453
----------------------------------------------------------------------------------------------------------------------------------

   1      1   380.7   393.4   403.8   422.9   430.0   428.8   440.6   442.1   442.5   449.4   451.2   443.9   448.6
   1      2   385.8   404.5   413.0   430.7   437.2   435.3   446.8   446.5   448.1   456.2   458.2   454.1   465.6
   1      3   351.7   366.4   377.3   398.0   403.5   405.8   414.3   418.3   409.7   420.9   421.4   417.8   427.3
   2      4   406.5   421.9   432.3   452.5   445.3   469.3   475.1   469.4   465.6   470.7   471.6   472.6   487.4
   2      5   382.7   399.5   414.0   430.4   429.7   447.8   454.3   452.9   452.6   456.6   456.1   452.1   455.3
   2      6   376.0   386.6   407.0   412.1   417.4   433.8   438.3   446.6   441.8   445.7   451.2   450.8   455.8
   3      7   364.8   379.6   397.3   412.6   410.9   427.2   430.8   428.8   439.1   440.3   438.3   444.8   456.5
   3      8   369.7   392.5   408.2   426.7   434.0   451.7   453.3   448.8   454.9   466.9   468.3   463.3   475.8
   3      9   364.2   381.5   391.6   407.9   415.7   425.8   428.9   428.5   434.1   436.1   443.8   448.3   475.7
   4     10   405.2   425.6   443.9   466.5   471.8   478.7   479.8   470.6   481.3   480.2   477.5   489.0   491.4
   4     11   403.8   415.2   435.1   444.6   459.9   465.9   467.9   470.4   472.7   476.5   476.7   485.5   487.4
   4     12   362.2   392.9   408.4   418.1   434.9   441.5   441.8   445.0   457.0   453.7   455.9   457.5   454.6
   5     13   333.6   359.9   367.9   382.7   390.8   394.9   397.5   405.0   410.4   411.4   412.0   423.8   422.9
   5     14   344.2   366.2   380.3   394.8   401.4   415.4   414.1   425.1   428.8   428.2   430.8   443.4   453.4
   5     15   346.0   361.0   382.8   397.2   403.7   406.8   412.6   411.8   418.1   420.4   427.0   441.8   445.7
   6     16   350.9   372.0   388.0   403.8   418.1   411.1   423.2   427.6   428.0   430.2   427.4   434.2   434.6
   6     17   350.6   374.6   378.9   396.2   405.0   399.7   406.9   414.4   412.3   419.3   420.0   428.0   436.6
   6     18   383.3   407.0   412.6   419.9   430.2   428.9   432.8   434.9   431.8   432.9   433.0   449.1   454.2
   7     19   390.8   405.4   405.4   412.3   437.0   439.2   435.6   445.6   444.8   442.1   429.9   438.1   439.5
   7     20   360.3   374.2   373.3   393.2   410.4   417.9   414.0   424.9   429.4   421.9   416.2   428.2   438.3
   7     21   365.1   387.7   391.5   409.4   415.8   425.5   423.6   433.4   428.1   431.7   425.6   428.3   436.2
   8     22   363.6   381.9   397.5   414.3   429.7   433.9   435.1   460.1   442.7   450.6   449.5   455.4   455.1
   8     23   347.0   370.0   370.0   387.2   392.6   393.2   400.9   407.1   405.1   405.8   401.8   411.5   419.9
   8     24   382.2   400.7   410.4   426.4   431.3   445.0   449.6   457.4   456.2   460.9   465.5   474.8   484.2
   9     25   366.9   392.1   401.0   413.7   421.8   433.8   435.4   438.3   438.2   436.2   431.5   444.7   452.7
   9     26   302.6   329.9   335.9   355.9   364.8   377.2   380.7   386.4   391.0   396.2   391.9   400.3   408.6
   9     27   369.9   404.6   403.9   420.7   429.7   446.1   447.8   457.3   462.3   468.8   465.2   478.8   488.7
  10     28   345.4   367.9   382.6   396.9   403.3   415.0   421.1   431.2   432.3   423.9   428.8   439.4   436.0
  10     29   342.7   364.5   378.5   387.1   387.0   399.6   400.7   408.3   413.8   405.6   413.0   421.8   395.9
  10     30   373.6   385.3   403.4   413.4   426.1   437.2   443.6   455.5   456.2   455.7   461.9   471.6   474.1
  11     31   370.0   381.7   402.2   421.0   433.1   435.4   437.5   447.2   453.4   452.9   454.9   461.2   470.4
  11     32   351.8   370.3   385.9   396.5   403.7   409.7   413.6   418.4   424.6   414.6   412.4   418.3   421.1
  11     33   376.9   383.5   406.1   419.3   430.6   443.1   439.9   448.3   446.7   443.2   446.9   453.1   462.1
  12     34   353.1   367.6   375.8   386.6   395.3   399.0   400.1   397.3   402.6   402.8   406.9   413.8   416.8
  12     35   371.1   385.5   393.5   411.8   429.6   430.9   433.7   437.5   438.5   441.5   443.3   452.4   459.2
  12     36   376.9   396.3   414.7   437.8   446.5   448.2   447.4   440.6   451.7   455.0   459.0   465.1   467.5
  13     37   358.9   375.2   393.8   409.9   412.5   422.0   417.1   422.3   430.8   434.2   437.4   443.0   447.8
  13     38   385.1   399.0   423.0   445.7   449.6   462.6   458.9   453.8   467.7   467.8   474.7   483.2   478.3
  13     39   349.3   359.8   379.8   391.3   389.2   397.6   395.9   402.2   404.1   497.6   406.9   406.1   403.0
  14     40   383.6   375.1   395.4   416.1   424.7   438.9   436.7   431.4   457.4   457.2   451.3   467.3   471.3
  14     41   352.5   360.7   368.8   382.2   380.6   388.4   380.6   379.3   393.0   384.8   376.7   393.8   397.0
  14     42   371.2   373.0   388.2   408.8   413.2   426.1   428.9   426.5   446.8   440.2   441.4   451.3   456.5
  15     43   386.3   405.3   420.0   429.7   434.8   442.8   444.2   444.6   457.7   460.7   456.8   461.2   465.4
  15     44   356.8   372.2   386.0   403.9   403.5   412.3   422.0   432.1   435.9   439.3   437.8   443.8   451.9
  15     45   356.4   377.4   392.5   401.9   402.6   416.9   421.5   423.7   434.7   430.6   430.3   433.5   435.2
  16     46   339.4   348.7   371.5   384.1   390.1   407.7   409.8   411.5   421.7   424.6   417.6   431.9   434.7
  16     47   357.3   375.3   390.4   409.2   416.5   421.5   430.4   433.8   442.9   441.6   435.8   445.4   450.6

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 29
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 0 PPM              TRT#:  1         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       117     145     173     201     229     257     285     313     341     369     397     425     453
----------------------------------------------------------------------------------------------------------------------------------

  16     48   362.7   372.6   398.2   402.1   405.3   421.9   423.0   424.0   439.4   433.6   427.7   432.0   432.3
  17     49   369.4   390.6   398.9   416.8   424.7   435.0   443.2   453.7   469.0   438.3   456.6   465.2   400.4 @
  17     50   361.0   378.9   385.3   397.0   402.1   401.9   408.4   416.2   419.6   418.9   420.7   418.6   418.5
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    365.2   382.3   395.3   410.4   417.5   425.9   428.8   432.7   437.3   439.5   437.9   444.7   448.0

SD             19.2    18.6    19.4    20.0    20.9    21.8    21.8    20.9    21.0    22.8    22.8    22.2    25.1

NO. OBSER.       50      50      50      50      50      50      50      50      50      50      50      50      50

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 30
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 0 PPM              TRT#:  1         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       481     509     537     565     593     621     649     677     705
----------------------------------------------------------------------------------------------------------------------------------

   1      1   434.8   437.2   430.7   438.3   440.2   437.7   434.9   433.0   424.3
   1      2   461.8   455.3   452.7   445.9   437.4   436.9   433.3   429.5   421.3
   1      3   428.4   424.3   425.3   431.4   418.5   414.0   410.6   409.7   374.9 @
   2      4   482.3   478.3   482.3   478.2   481.3   478.9   474.9   478.7   451.4
   2      5   451.7   450.2   447.4   448.7   447.1   444.7   436.0   432.2 @
   2      6   456.3   451.2   444.8   446.6   448.7   446.7   457.7 @
   3      7   444.0   438.8   439.1   435.9   418.5   422.2   420.2   416.2   295.1 @
   3      8   470.1   472.4   473.4   467.6   459.7   462.5   464.3   455.1   443.0
   3      9   428.6   431.7   427.2   414.8   414.5   410.1   375.9 @
   4     10   495.1   485.7   469.4   478.5   464.3   420.5   391.4   329.5 @
   4     11   488.1   481.6   470.6   476.9   473.5   471.5   458.3   420.4 @
   4     12   452.6   486.3   433.7   450.4   430.8   366.3 @
   5     13   427.9   416.5   415.9   424.5   417.8   309.4   403.6   396.5   394.9
   5     14   454.8   463.4   449.3   431.9   424.0   315.2   388.0   298.8 @
   5     15   444.6   431.7   430.1   423.9   423.4   314.5   415.1   406.1   403.5
   6     16   445.8   444.1   438.7   441.7   433.1   423.8   425.6   416.0   430.4
   6     17   438.7   433.9   426.8   413.2   409.3   400.0   407.5   402.0   405.2 @
   6     18   457.0   450.7   453.1   448.7   446.2   435.2   430.8   423.9   428.1
   7     19   436.7   442.7   441.7   440.7   441.9   423.7   421.9   425.2   374.2
   7     20   433.9   426.0   428.6   430.4   428.8   427.8   427.3   424.1   419.1
   7     21   429.1   408.3   415.7   421.0   426.8   429.3   436.6   452.3   437.9
   8     22   455.2   444.3   452.7   435.8   435.6   420.4   423.3   425.6   410.3
   8     23   421.6   416.4   393.2 @
   8     24   477.3   466.6   469.7   462.6   457.0   446.9   439.9   436.5   428.3
   9     25   442.4   431.9   431.6   430.0   430.3   411.3   416.4   423.8   324.2
   9     26   405.6   399.0   398.7   401.0   392.7   382.7   387.7   385.2   293.5
   9     27   480.2   474.8   476.2   473.3   467.9   452.9   460.7   470.0   369.9
  10     28   431.3   424.9   426.5   418.8 @
  10     29   410.4   400.6   400.5   363.5   333.0 @
  10     30   474.2   463.9   465.9   464.9   453.3   428.3   424.3   411.2   401.3
  11     31   458.6   453.2   458.8   457.6   452.9   447.8   451.9   445.4   441.6
  11     32   415.1   404.6   408.6   406.4   402.1   395.6   398.6   391.3   386.2
  11     33   452.1   447.0   450.0   453.6   451.1   456.1   462.2   465.5   462.6
  12     34   413.2   408.3   399.4   404.9   412.7   408.5   410.2   417.8   412.2
  12     35   460.3   455.9   457.1   463.8   469.2   478.1   501.0   506.5 @
  12     36   462.5   450.2   448.6   450.8   446.4   444.5   443.9   438.1   436.7
  13     37   448.2   441.5   441.1   443.9   441.2   444.3   451.6   452.1   401.7
  13     38   472.7   467.7   469.8   472.4   465.1   466.1   462.9   454.2   392.8
  13     39   406.5   499.1   398.4   398.9   396.5   397.9   402.4   400.0   337.4 @
  14     40   460.4   470.8   470.5   477.7   474.1   479.3   486.3   492.1   500.5
  14     41   384.2   386.9   383.2   376.0   376.2   374.3   378.4   379.2   380.6
  14     42   454.9   458.1   454.5   448.2   446.6   441.9   441.3   441.0   439.4
  15     43   462.5   465.9   484.4   498.7 @
  15     44   439.6   435.9   431.8   430.9   430.5   420.9   424.2   425.5   420.6
  15     45   435.6   424.6   410.9   401.9   394.9   392.6   384.4   384.2   375.7
  16     46   435.8   433.1   424.3   427.5   425.5   421.2   331.3 @
  16     47   452.7   457.0   444.7   430.9   446.1   432.0   427.7   420.3   401.0

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 31
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 0 PPM              TRT#:  1         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       481     509     537     565     593     621     649     677     705
----------------------------------------------------------------------------------------------------------------------------------

  16     48   434.9   434.4   432.4   429.8   430.0   426.9   423.1   405.2   307.0 @
  17     49
  17     50   408.3   403.4   394.4   402.5   394.1   390.6   387.4   384.2   380.9
              -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    445.3   443.5   438.3   437.8   432.8   421.2   425.8   422.1   400.2

SD             23.4    25.7    25.7    27.8    28.4    39.7    32.5    38.2    45.9

NO. OBSER.       49      49      49      48      46      45      44      41      36

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 32
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 625 PPM            TRT#:  3         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      12      19      26      33      40      47      54      61      68      75      82      89
----------------------------------------------------------------------------------------------------------------------------------

  18     51   118.8   165.7   195.5   224.2   241.0   254.5   268.3   283.0   288.0   299.8   303.5   315.0   324.6
  18     52   141.1   193.7   222.3   253.7   268.7   282.5   295.5   312.6   320.3   331.3   331.5   341.6   343.0
  18     53   139.6   196.5   230.2   264.9   283.1   296.9   310.0   327.4   338.8   352.0   357.5   368.7   376.5
  19     54   125.5   188.2   222.8   254.6   273.7   289.9   304.9   321.7   334.7   339.0   341.7   351.7   351.9
  19     55   124.6   173.1   198.9   227.3   243.2   256.3   267.6   283.4   294.6   298.5   304.5   309.5   310.6
  19     56   108.3   159.1   192.2   226.3   247.2   260.6   276.5   297.8   310.6   320.3   320.2   334.4   340.0
  20     57   127.0   172.9   202.6   233.0   250.8   264.8   278.8   299.1   310.4   318.0   321.3   331.2   330.3
  20     58   111.6   160.5   188.4   221.1   236.1   250.4   260.1   274.9   282.0   292.0   299.5   311.0   311.6
  20     59   122.7   177.4   210.2   242.7   259.5   277.8   287.1   303.4   314.9   324.3   328.0   338.3   334.3
  21     60   103.3   154.6   189.0   218.2   236.3   250.7   265.8   280.9   290.8   295.2   301.3   311.6   308.6
  21     61   137.5   191.1   221.0   246.7   265.9   283.3   294.1   314.5   321.3   329.0   335.1   344.6   343.0
  21     62   105.3   153.8   182.7   213.8   231.7   248.3   261.7   277.9   289.2   296.9   302.7   310.9   313.0
  22     63   121.6   171.3   203.5   230.6   252.1   265.9   281.7   301.1   313.0   324.1   325.3   335.0   337.8
  22     64   119.3   170.3   203.5   233.4   253.0   272.7   285.5   305.8   313.2   323.9   326.2   334.9   333.0
  22     65   133.3   180.0   207.7   234.8   251.6   263.4   276.6   291.8   302.7   312.8   314.1   320.1   317.2
  23     66   111.7   161.4   190.2   218.5   225.4   238.9   251.7   270.0   285.9   295.7   299.0   307.9   314.8
  23     67   119.9   172.0   202.7   232.5   248.1   274.2   282.2   300.5   314.6   322.1   327.4   333.2   340.9
  23     68   130.3   183.1   222.2   252.1   269.2   285.9   304.0   322.4   329.1   342.5   344.0   360.7   360.6
  24     69   141.2   194.8   226.2   258.6   276.7   293.5   310.7   329.6   341.2   348.9   353.9   368.4   375.9
  24     70   133.3   178.8   209.0   238.4   253.3   275.3   290.7   311.0   320.7   335.6   339.7   347.2   352.4
  24     71   124.3   178.4   206.0   234.4   251.3   263.7   275.0   296.5   301.0   305.0   314.8   324.6   328.2
  25     72   104.1   153.9   187.2   218.5   235.6   252.9   263.2   278.5   286.4   293.2   297.6   300.0   309.0
  25     73   114.7   167.3   202.5   232.1   250.8   265.8   280.1   296.5   306.9   317.8   322.4   323.3   328.7
  25     74   120.8   175.0   208.4   231.8   244.3   260.5   274.5   292.0   303.4   310.1   317.1   320.6   320.2
  26     75   124.6   171.7   201.1   229.1   241.2   257.2   271.7   290.0   299.9   310.5   311.7   318.6   319.8
  26     76   124.3   171.5   203.4   231.7   247.7   263.3   278.6   295.4   301.0   305.9   305.7   310.2   315.2
  26     77   107.3   150.1   178.6   204.5   215.5   226.0   237.9   255.7   263.3   273.8   272.5   276.8   283.3
  27     78   130.0   179.8   213.4   247.7   266.3   284.8   299.4   315.2   326.3   335.0   344.3   356.3   365.5
  27     79   137.7   184.3   211.0   237.8   248.1   258.8   265.2   279.4   289.2   300.0   305.7   315.1   320.7
  27     80   119.4   162.2   189.5   215.4   231.5   248.8   263.4   277.0   285.8   293.3   299.6   310.5   309.7
  28     81   139.6   193.4   226.8   260.6   274.9   292.9   308.0   329.5   337.9   350.4   356.1   365.4   353.6
  28     82   116.9   162.4   194.3   223.3   238.2   254.4   266.7   288.1   302.7   312.4   321.7   328.9   332.1
  28     83   121.9   173.6   207.4   242.9   259.6   280.0   294.5   313.6   328.8   340.1   341.9   351.8   343.7
  29     84   135.5   188.8   221.8   253.7   264.9   277.2   289.9   308.3   314.9   326.6   328.0   338.0   337.6
  29     85   119.6   177.9   218.6   255.6   277.2   298.6   316.7   342.7   355.8   370.6   375.2   391.2   398.8
  29     86   139.0   184.2   211.8   239.2   251.6   263.3   276.2   290.5   297.9   310.2   309.6   320.1   319.2
  30     87   112.6   162.1   196.1   227.2   239.9   257.2   279.7   295.2   300.5   311.0   317.8   329.2   330.2
  30     88   128.5   176.7   205.0   237.9   252.7   267.7   288.0   305.0   311.1   322.7   332.6   344.1   342.7
  30     89   123.7   166.9   194.3   225.1   235.0   245.0   265.8   280.5   288.6   306.7   313.8   320.7   322.1
  31     90   105.2   150.4   183.0   214.2   229.7   247.8   259.2   276.5   282.3   294.0   297.0   304.7   302.7
  31     91   143.9   188.2   216.2   246.4   257.7   272.7   285.1   299.3   310.6   326.8   327.3   332.2   300.4
  31     92   137.9   194.3   223.8   259.8   275.0   291.2   309.4   326.0   333.8   345.5   347.6   363.2   360.8
  32     93   120.3   168.9   202.8   231.8   246.5   259.3   269.4   281.3   289.6   298.0   301.8   309.6   314.6
  32     94   113.6   160.8   191.3   220.5   235.3   251.1   263.8   281.5   291.0   304.4   309.6   321.0   322.2
  32     95   126.2   172.9   201.4   228.9   241.6   259.6   270.5   287.3   296.6   306.0   309.5   318.7   318.8
  33     96   119.0   168.4   199.5   231.7   247.8   262.2   278.1   294.6   306.8   324.0   314.7   335.1   320.7
  33     97   136.6   186.7   213.1   247.0   261.2   281.4   295.2   313.9   323.9   334.5   340.6   348.0   349.2

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 33
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 625 PPM            TRT#:  3         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      12      19      26      33      40      47      54      61      68      75      82      89
----------------------------------------------------------------------------------------------------------------------------------

  33     98   124.3   171.1   202.9   229.5   239.0   253.8   268.8   288.5   297.8   308.1   313.3   323.0   338.3
  34     99   126.0   175.1   205.9   234.8   248.0   265.2   277.6   293.4   305.1   317.8   323.4   339.2   340.3
  34    100   106.7   156.9   188.1   219.4   234.2   253.3   266.8   279.0   287.2   301.5   303.0   316.2   314.6
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    123.6   173.4   204.5   234.8   250.2   266.0   279.8   297.2   306.8   317.2   321.0   330.6   331.7

SD             11.1    12.5    12.9    14.0    15.0    16.0    16.9    18.1    18.7    19.4    19.5    21.3    21.7

NO. OBSER.       50      50      50      50      50      50      50      50      50      50      50      50      50

AVE. BODY WT
REL. TO CNTL   1.00    0.97    0.97    0.98    0.98    0.99    0.98    0.98    0.98    0.98    0.97    0.97    0.96
(TRT#:    1 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 34
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 625 PPM            TRT#:  3         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       117     145     173     201     229     257     285     313     341     369     397     425     453
----------------------------------------------------------------------------------------------------------------------------------

  18     51   340.7   355.4   378.9   383.7   390.3   402.2   398.6   410.1   405.5   419.9   406.5   420.3   424.2
  18     52   360.3   380.0   393.4   396.6   414.5   413.2   422.6   427.4   429.7   432.3   432.2   433.4   438.2
  18     53   393.7   406.9   431.5   433.6   448.6   459.4   455.5   459.5   469.2   472.2   469.6   473.7   482.4
  19     54   373.1   397.6   408.8   419.0   433.3   439.7   441.4   443.3   444.8   452.0   455.3   452.1   457.1
  19     55   319.9   344.6   353.5   360.3   375.5   376.4   379.2   382.5   388.0   496.6   399.9   397.5   406.2
  19     56   355.2   374.4   381.5   394.9   406.5   411.8   417.1   428.0   429.7   429.8   430.2   438.7   449.6
  20     57   354.4   375.2   385.8   399.9   406.3   411.2   413.9   419.3   419.5   435.5   433.3   437.9   443.2
  20     58   326.9   349.5   360.1   361.2   382.7   389.1   396.9   400.5   400.5   406.6   410.8   416.4   425.2
  20     59   352.8   375.5   377.8   391.3   408.8   415.8   413.0   416.8   419.7   426.2   424.7   430.3   436.5
  21     60   328.5   349.4   363.3   376.3   382.7   391.6   393.9   401.8   400.9   405.0   407.7   408.3   417.0
  21     61   359.5   370.8   379.1   390.9   401.6   409.1   405.1   412.5   413.6   418.6   420.1   422.9   428.3
  21     62   339.9   357.4   363.1   379.1   377.8   387.8   393.1   395.6   398.9   402.7   400.0   403.0   403.1
  22     63   358.9   379.4   393.0   404.6   407.8   420.3   429.0   429.9   420.9   422.8   417.7   421.5   427.7
  22     64   355.4   372.6   395.5   407.0   380.3   417.6   413.2   420.7   413.2   427.5   423.4   419.8   430.8
  22     65   336.9   358.6   375.2   382.5   388.5   397.4   399.3   403.0   394.7   409.4   409.7   413.2   417.4
  23     66   338.4   359.9   370.9   381.0   393.4   386.3   396.2   401.0   411.0   417.7   415.8   424.8   427.0
  23     67   356.8   378.2   381.8   397.8   414.2   413.2   418.9   426.5   427.1   429.4   432.5   434.5   439.6
  23     68   378.4   404.5   412.0   436.5   443.9   448.0   453.4   455.1   451.9   460.1   457.2   457.2   463.1
  24     69   402.7   414.6   421.8   437.1   427.8   430.4   443.4   444.7   444.2   445.0   438.8   433.5   440.4
  24     70   380.1   395.7   406.8   425.0   426.8   423.9   432.9   433.5   444.4   447.2   445.9   440.2   457.1
  24     71   357.1   372.6   389.6   404.3   389.4   342.3 @
  25     72   336.6   353.0   365.4   375.3   384.7   391.4   401.4   398.7   409.4   412.2   405.7   407.7   416.7
  25     73   353.4   373.7   389.2   404.7   411.8   409.7   428.7   434.7   438.4   432.4   407.7   416.7   416.9
  25     74   350.3   367.5   381.7   400.2   410.5   416.3   420.9   428.7   437.2   439.9   435.8   450.3   457.0
  26     75   337.1   355.8   367.6   377.1   387.7   391.0   390.2   397.2   401.6   404.5   406.2   407.3   412.3
  26     76   328.4   351.0   365.2   372.6   385.3   386.4   388.4   397.6   393.0   431.0   389.8   391.5   401.9
  26     77   306.0   324.7   337.7   348.6   362.6   361.2   369.0   376.1   382.1   390.3   390.7   398.4   406.3
  27     78   368.6   384.9   401.7   417.7   434.2   440.3   449.4   443.9   449.6   446.3   445.2   448.4   451.8
  27     79   336.8   358.3   364.4   371.9   382.5   386.8   387.5   396.6   406.0   402.3   404.2   417.2   414.9
  27     80   325.3   344.4   349.5   364.3   380.4   387.7   387.9   398.8   400.0   395.2   394.9   398.8   406.8
  28     81   370.4   393.6   392.4   416.9   420.3   417.7   427.4   434.9   440.7   445.5   436.1   447.5   455.9
  28     82   356.9   376.7   381.8   391.2   406.0   411.6   416.4   421.7   425.3   431.8   430.3   437.0   450.8
  28     83   363.1   380.1   391.8   419.5   420.2   425.9   434.6   436.7   439.9   451.3   433.5   443.3   461.3
  29     84   359.3   377.1   390.5   405.7   418.7   425.5   424.4   430.7   427.2   437.0   440.6   450.4   457.4
  29     85   423.0   441.1   454.2   469.9   472.8   480.3   483.7   483.2   479.2   490.8   483.3   483.4   496.9
  29     86   334.4   356.1   368.9   376.2   386.6   392.8   396.7   399.5   402.3   404.7   398.5   396.5   408.0
  30     87   362.1   339.4   385.5   396.5   399.5   420.4   418.0   423.8   421.5   416.1   432.4   426.5   433.7
  30     88   367.4   350.6   400.8   414.9   412.8   432.8   438.9   442.3   444.9   491.3   449.4   451.7   455.5
  30     89   348.6   336.3   380.6   396.4   398.7   422.6   423.5   425.8   433.6   422.1   444.3   444.8   449.6
  31     90   318.4   335.9   349.2   365.5   359.7   343.1 @
  31     91   343.1   355.6   370.0   383.0   367.1   403.3   399.8   404.4   412.0   407.0   406.0   416.0   425.0
  31     92   383.1   394.8   408.7   424.3   406.0   442.2   444.2   434.7   439.1   436.6   436.3   443.0   449.6
  32     93   339.0   353.5   370.8   389.3   394.6   396.7   401.7   410.3   400.8   405.9   405.5   406.5   411.1
  32     94   335.7   344.9   368.9   381.8   390.4   391.8   390.7   388.5   393.8   396.1   398.5   404.2   420.1
  32     95   332.7   295.0   359.5   366.2   381.8   378.5   381.5   384.4   393.5   396.2   397.7   398.2   407.6
  33     96   357.8   366.8   382.3   402.4   412.9   420.9   422.0   434.1   445.0   449.0   450.2   456.7   461.9
  33     97   368.0   391.3   394.8   414.3   421.8   422.3   431.6   433.6   439.1   444.0   460.2   444.2   430.6 @

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 35
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 625 PPM            TRT#:  3         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       117     145     173     201     229     257     285     313     341     369     397     425     453
----------------------------------------------------------------------------------------------------------------------------------

  33     98   343.9   363.8   375.3   390.3   401.7   409.1   407.1   416.7   416.9   421.5   424.2   430.7   434.4
  34     99   365.5   385.7   391.8   408.7   416.2   422.0   425.3   428.3   426.2   432.5   431.1   441.1   444.1
  34    100   334.0   351.4   362.9   377.4   384.4   381.9   392.1   392.0   400.5   397.2   407.7   413.2   426.1
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    352.4   367.5   382.5   395.7   402.3   408.0   414.6   419.0   421.4   428.9   424.5   428.1   435.0

SD             22.1    24.8    21.6    23.5    22.6    26.2    23.3    22.0    21.9    25.3    22.0    21.4    21.7

NO. OBSER.       50      50      50      50      50      50      48      48      48      48      48      48      48

AVE. BODY WT
REL. TO CNTL   0.96    0.96    0.97    0.96    0.96    0.96    0.97    0.97    0.96    0.98    0.97    0.96    0.97
(TRT#:    1 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 36
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 625 PPM            TRT#:  3         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       481     509     537     565     593     621     649     677     705
----------------------------------------------------------------------------------------------------------------------------------

  18     51   415.7   424.0   427.5   422.3   422.9   411.5   416.2   384.3   394.6
  18     52   434.3   421.2   411.6   384.3 @
  18     53   487.0   479.0   485.3   474.5   482.4   470.8   471.1   451.5   454.1
  19     54   441.3   445.1   445.7   441.3   443.5   427.4   436.0   433.2   421.5
  19     55   409.4   408.0   407.6   403.3   404.0   400.2   408.0   391.1   384.3
  19     56   438.3   437.2   443.2   439.4   433.1   426.3   434.6   430.4   411.9
  20     57   440.2   440.3   446.4   421.9   431.7   431.6   439.7   433.4   431.8
  20     58   420.5   418.1   399.1   342.1 @
  20     59   435.9   432.8   434.9   407.4   421.6   418.3   423.0   413.2   409.9
  21     60   412.9   409.8   420.5   412.0   416.6   418.7   419.6   418.3   417.1
  21     61   425.5   420.4   424.0   413.5   412.3   411.8   416.4   412.8   408.4
  21     62   399.4   396.6   399.7   394.4   391.5   387.2   392.6   385.2   387.4
  22     63   424.8   420.2   433.8   423.6   421.9   415.4   424.7   420.4 @
  22     64   435.9   422.1   439.8   425.9   419.2   421.9   430.7   431.1   417.7
  22     65   415.4   411.1   416.8   408.7   426.0   402.4   408.2   404.4   393.0
  23     66   426.1   416.6   415.8   425.5   424.5   415.7   435.4   435.6   427.6
  23     67   438.6   430.0   432.5   432.1   422.7 @
  23     68   460.2   451.2   450.1   447.2   440.7   431.4   444.0   437.5   432.0
  24     69   431.1   423.0   423.0   417.0   343.7   403.4   407.2   407.2   396.2
  24     70   444.7   414.3 @
  24     71
  25     72   412.0   407.9   413.6   410.6   401.9   396.3   399.9   400.0   384.2
  25     73   404.2   396.1   381.7 @
  25     74   450.7   440.2   448.1   435.2   427.7   416.5   428.2   430.5   421.6
  26     75   406.9   408.7   413.4   419.4   404.3   371.8 @
  26     76   398.5   396.4   400.2   404.0   403.2   390.7   404.4   400.1   391.9
  26     77   401.3   396.6   398.8   408.1   396.3   393.6   394.9   392.6   389.7
  27     78   444.6   428.7   436.6   430.7   428.1   425.4   429.2   417.1   395.0
  27     79   393.8   373.6   348.2   376.4   341.2   342.1   336.3   349.5 @
  27     80   409.6   388.5   388.8   390.3   384.0   375.7   384.1   361.7 @
  28     81   450.3   446.3   454.0   439.4   441.2   429.0   440.7   434.5   432.4
  28     82   443.6   433.9   435.0   428.7   423.7   422.1   425.2   415.6   422.3
  28     83   460.2   451.0   452.3   442.8   434.4   431.7   437.5   428.0   422.1
  29     84   467.7   468.1   462.9   424.8 @
  29     85   492.5   481.2   492.8   488.6   473.5   434.0   450.0   429.5   384.2 @
  29     86   411.0   404.1   405.7   396.6   385.5   373.5   389.9   382.7   372.5
  30     87   427.9   423.0   412.6   415.8   415.1   405.7   410.7   405.8   404.4
  30     88   449.2   439.2   436.5   440.2   433.7   419.3   423.8   420.3   404.5
  30     89   447.0   445.2   443.8   440.5   445.1   431.8   443.6   438.8   416.4
  31     90
  31     91   422.8   418.6   410.8   413.9   413.8   403.5   404.2   398.2   390.2
  31     92   444.8   441.8   433.4   442.4   439.2   429.6   440.5   420.9   405.9
  32     93   399.3   397.4   401.5   399.3   392.7   393.4   367.7 @
  32     94   403.6   397.6   398.1   394.6   384.5   377.9   363.2   370.2   367.1
  32     95   404.1   400.6   403.8   396.8   393.1   385.6   364.0   368.3   357.1
  33     96   451.1   451.6   449.0   446.8   440.0   442.8   451.7   411.8   439.1
  33     97

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 37
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 625 PPM            TRT#:  3         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       481     509     537     565     593     621     649     677     705
----------------------------------------------------------------------------------------------------------------------------------

  33     98   424.2   424.5   421.8   424.7   422.1   421.2   423.7   442.8   407.3
  34     99   443.7   434.7   421.3   407.9   390.8   371.6   355.2   326.1 @
  34    100   416.5   408.5   407.6   404.5   402.4   362.5   399.1   387.1   387.2
              -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    430.2   423.9   424.6   419.1   416.1   408.3   414.4   408.2   405.2

SD             22.9    23.0    26.2    25.0    27.5    25.1    29.0    27.6    21.5

NO. OBSER.       47      47      46      45      42      41      40      39      35

AVE. BODY WT
REL. TO CNTL   0.97    0.96    0.97    0.96    0.96    0.97    0.97    0.97    1.01
(TRT#:    1 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 38
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 1250 PPM           TRT#:  5         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      12      19      26      33      40      47      54      61      68      75      82      89
----------------------------------------------------------------------------------------------------------------------------------

  35    101   121.3   163.4   190.0   218.1   235.8   248.5   263.4   276.3   284.1   288.8   288.1   291.7   292.9
  35    102   125.4   168.0   203.1   234.5   254.6   269.5   282.2   299.5   309.7   316.7   318.0   326.4   326.6
  35    103   113.4   153.8   182.2   215.5   237.7   257.1   272.1   288.6   301.0   298.8   297.1   303.9   306.3
  36    104   121.7   162.3   188.6   213.2   228.4   239.2   252.6   265.5   271.1   279.8   279.4   287.0   287.2
  36    105   139.3   182.4   213.0   240.7   256.9   269.0   278.5   287.9   289.6   292.8   300.7   307.7   308.7
  36    106   120.2   161.4   192.2   221.9   242.0   257.5   270.6   285.1   290.4   293.3   293.6   300.9   300.9
  37    107   141.0   186.8   214.8   242.7   263.0   281.3   291.9   305.7   307.5   312.9   312.1   322.0   325.7
  37    108   116.3   160.8   167.4   219.3   239.2   259.2   273.4   286.1   290.4   293.9   297.3   312.1   316.1
  37    109   136.5   181.2   209.0   237.9   256.8   271.3   281.0   290.0   292.0   294.3   294.3   303.7   303.8
  38    110   103.2   146.1   180.2   211.5   226.8   242.9   256.1   269.0   274.6   281.2   287.8   297.8   297.0
  38    111   110.6   161.3   192.1   220.3   235.6   248.6   260.4   276.5   280.2   291.8   290.1   299.5   297.7
  38    112   124.9   168.0   197.7   224.7   243.4   260.3   274.8   288.7   298.2   304.0   309.7   318.9   315.5
  39    113   127.4   173.9   208.5   237.3   252.1   267.1   277.4   296.6   305.9   316.8   314.3   324.8   326.9
  39    114   135.7   183.6   209.3   234.3   248.7   263.0   270.8   288.7   299.9   306.9   308.2   315.8   312.9
  39    115   116.7   148.3   170.1   188.7   200.8   212.2   218.4   228.4   232.6   237.2   238.3   247.3   251.2
  40    116   128.0   172.7   198.0   221.3   236.8   247.1   259.2   274.6   285.5   295.5   302.6   304.3   303.6
  40    117   109.3   148.9   176.5   203.5   213.6   229.5   245.5   261.2   273.3   287.5   297.7   303.7   298.7
  40    118   137.4   176.3   204.1   229.9   244.3   258.5   270.7   287.5   296.2   303.7   304.0   304.2   297.2
  41    119   131.5   172.7   200.7   222.9   242.0   253.3   264.9   278.5   285.0   294.4   294.2   298.5   298.0
  41    120   118.8   158.6   185.7   213.3   230.9   244.6   254.4   272.3   281.4   287.8   296.5   300.5   305.2
  41    121   127.6   164.7   189.5   211.3   227.5   241.0   251.4   266.5   276.6   287.0   287.8   294.2   293.6
  42    122   109.1   151.0   181.6   212.5   230.0   245.8   257.3   276.4   286.9   299.9   303.2   316.2   318.5
  42    123   137.8   181.5   205.6   233.3   243.5   257.5   267.7   283.6   289.0   294.3   291.9   302.8   301.5
  42    124   118.6   161.5   188.5   216.7   232.7   246.6   257.7   275.0   286.8   295.7   292.0   297.7   296.5
  43    125   115.5   155.9   184.1   211.2   225.5   242.9   249.3   259.8   263.0   265.5   270.9   277.1   280.9
  43    126   112.2   157.5   181.6   207.0   221.2   233.1   246.5   262.1   268.9   273.8   273.6   284.0   284.7
  43    127   111.6   155.4   188.0   214.9   231.8   248.2   260.3   269.8   276.4   280.3   280.9   291.2   290.9
  44    128   125.2   170.5   198.0   225.7   238.4   253.8   263.5   279.8   289.5   298.2   301.1   310.0   309.4
  44    129   136.0   179.6   204.4   232.2   248.6   264.8   279.3   294.5   304.5   304.7   304.7   311.6   310.0
  44    130   130.6   177.5   209.1   241.9   256.9   273.3   289.6   306.9   320.1   329.4   330.1   341.1   342.2
  45    131   128.8   169.0   197.4   223.9   240.9   259.1   274.4   291.5   303.2   312.8   311.0   316.6   319.7
  45    132   130.7   171.6   197.0   221.9   237.8   251.7   265.0   280.7   287.2   295.0   292.7   303.9   305.3
  45    133   107.9   141.6   167.9   190.1   206.5   219.4   229.7   240.6   247.5   259.3   260.4   267.8   273.0
  46    134   135.3   180.8   204.5   233.1   246.3   262.9   274.4   293.0   304.6   309.7   312.0   319.8   318.6
  46    135   111.7   153.0   185.4   215.1   230.3   245.3   257.9   279.9   286.3   294.5   297.0   305.7   301.2
  46    136   106.5   148.8   179.7   211.3   232.3   254.5   268.5   289.3   298.3   309.5   309.8   317.3   315.4
  47    137   128.2   173.7   204.9   230.2   247.8   262.0   271.2   286.2   290.4   294.2   299.4   311.0   314.9
  47    138   127.1   164.0   194.6   223.5   239.6   255.4   270.5   288.0   293.7   297.9   296.7   304.8   305.0
  47    139   121.6   157.5   189.1   217.7   233.2   250.7   261.5   277.1   283.9   288.5   288.6   298.4   301.0
  48    140   123.5   161.6   187.1   215.7   231.0   244.2   261.3   275.1   284.3   288.2   293.3   297.9   256.7
  48    141   116.9   160.5   191.5   223.8   241.6   258.0   274.1   293.4   302.0   305.8   305.4   310.1   306.8
  48    142   138.7   181.5   209.6   238.5   248.8   266.0   276.8   295.1   304.1   307.5   310.4   314.6   306.0
  49    143   113.2   158.7   192.6   222.7   238.7   251.9   266.5   280.0   289.2   298.0   298.4   306.5   301.8
  49    144   101.3   145.0   178.6   208.1   226.7   243.8   258.7   278.2   289.2   295.5   295.7   306.3   305.1
  49    145   128.3   170.2   199.8   226.3   240.6   254.7   267.0   285.0   294.8   303.5   302.9   312.5   312.1
  50    146   127.2   168.4   193.8   223.3   237.4   253.5   266.4   281.5   294.1   301.4   300.2   268.9   298.4
  50    147   116.4   157.5   186.1   214.4   226.5   239.6   253.3   270.4   280.3   290.5   290.8   301.8   299.0

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 39
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 1250 PPM           TRT#:  5         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      12      19      26      33      40      47      54      61      68      75      82      89
----------------------------------------------------------------------------------------------------------------------------------

  50    148   114.7   149.2   176.7   199.0   213.7   223.5   231.9   246.3   253.5   258.8   261.1   268.4   271.6
  51    149   139.2   182.4   215.3   238.7   254.3   269.3   280.1   296.8   305.9   317.5   321.4   327.2   320.7
  51    150   131.6   173.4   205.6   236.9   247.2   265.1   273.0   295.9   306.7   321.1   325.6   333.3   328.1
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    123.0   165.1   193.4   221.4   237.3   252.3   264.5   280.1   288.2   295.1   296.7   303.8   303.2

SD             10.6    11.8    12.3    12.5    12.9    13.8    14.3    15.4    16.2    16.6    16.4    17.3    17.0

NO. OBSER.       50      50      50      50      50      50      50      50      50      50      50      50      50

AVE. BODY WT
REL. TO CNTL   0.99    0.92    0.92    0.92    0.93    0.94    0.92    0.92    0.92    0.91    0.90    0.89    0.88
(TRT#:    1 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 40
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 1250 PPM           TRT#:  5         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       117     145     173     201     229     257     285     313     341     369     397     425     453
----------------------------------------------------------------------------------------------------------------------------------

  35    101   312.8   326.3   342.3   332.3   347.1   370.6   374.9   372.7   379.9   382.8   381.1   388.1   393.5
  35    102   334.4   346.7   353.0   364.1   361.6   382.9   380.2   383.9   386.8   388.4   384.2   391.0   401.5
  35    103   328.4   337.6   354.3   367.5   365.3   381.3   383.4   387.5   387.4   397.1   391.6   397.7   403.3
  36    104   306.5   323.4   331.8   349.5   351.2   356.0   356.4   360.1   369.6   366.9   366.2   377.1   379.3
  36    105   334.0   355.4   363.8   379.7   386.2   394.8   394.6   400.2   403.2   406.9   407.2   413.6   414.7
  36    106   318.7   335.2   343.6   358.3   369.0   375.3   372.2   376.4   384.0   386.3   380.8   390.3   388.2
  37    107   347.0   360.0   373.9   383.4   396.1   400.7   408.7   413.4   420.9   421.3   413.8   425.2   432.9
  37    108   333.3   354.2   365.7   375.2   389.3   386.0   382.0   394.6   395.2   395.2   391.7   398.6   407.2
  37    109   323.7   344.0   348.4   359.4   370.1   370.8   371.2   374.4   381.6   379.3   376.5   382.1   390.0
  38    110   314.8   332.3   345.9   354.4   361.8   372.0   367.9   379.1   388.7   384.3   391.0   392.8   397.8
  38    111   311.2   326.6   335.6   345.7   323.3   362.9   358.7   360.6   372.1   369.8   371.2   368.6   370.7
  38    112   335.3   356.7   368.0   374.8   380.1   396.8   398.7   400.3   409.2   408.9   409.2   409.1   415.1
  39    113   338.4   354.7   365.2   366.4   379.2   383.3   382.5   396.0   404.6   400.5   405.7   406.6   409.8
  39    114   324.0   336.0   349.3   360.5   378.8   387.8   383.2   392.0   399.7   400.3   403.7   413.7   413.2
  39    115   278.1   301.3   314.5   326.8   339.2   344.9   345.9   352.0   358.7   358.4   360.7   369.7   374.5
  40    116   324.4   339.5   342.1   354.6   360.6   369.3   377.0   379.0   385.8   382.9   381.5   389.3   395.4
  40    117   332.2   344.2   346.1   361.7   368.6   374.3   385.6   382.1   388.7   389.2   388.9   401.0   405.4
  40    118   330.4   346.9   351.9   366.7   370.9   368.3   372.4   372.5   378.3   384.4   379.7   384.3   386.9
  41    119   314.8   333.4   341.5   349.0   357.1   361.9   365.6   368.8   375.6   371.0   373.6   379.3   353.1
  41    120   319.5   335.0   350.2   363.8   374.3   378.6   382.2   383.2   397.7   399.2   399.2   400.5   371.9
  41    121   305.8   320.6   325.9   339.7   344.7   349.0   358.6   359.0   364.7   361.9   364.3   369.4   350.4
  42    122   332.4   346.3   360.7   374.3   383.0   390.4   393.0   391.2   401.7   391.1   388.0   398.5   397.2
  42    123   315.8   328.1   342.3   353.3   358.7   368.4   370.7   370.9   380.9   378.9   378.4   382.9   326.1
  42    124   314.2   326.0   331.6   344.2   353.3   356.5   364.9   362.9   364.9   364.4   367.0   377.3   369.7
  43    125   298.2   311.4   323.1   341.0   346.5   355.3   356.3   361.9   366.2   369.7   365.0   372.0   319.6
  43    126   304.5   331.1   344.7   355.0   358.6   369.1   361.5   361.5   369.4   364.3   366.5   377.1   374.9
  43    127   306.2   323.9   330.8   347.4   351.6   358.1   358.7   360.2   362.7   365.8   367.2   369.4   373.1
  44    128   326.2   342.2   355.0   372.3   373.7   384.7   383.4   384.3   392.1   393.3   393.7   403.2   396.5
  44    129   333.0   342.3   357.0   376.8   381.3   386.7   391.6   391.9   397.8   398.9   405.6   408.1   405.1
  44    130   355.2   378.4   393.9   413.4   422.8   435.4   432.5   429.2   441.3   440.2   449.5   455.1   446.0
  45    131   341.4   359.4   376.3   393.7   394.7   403.9   403.7   411.6   417.0   421.8   430.0   431.8   437.4
  45    132   331.7   348.2   357.6   372.9   377.5   389.4   364.4   396.8   397.7   394.7   400.7   406.6   410.1
  45    133   293.6   311.6   320.2   335.4   339.0   351.3   331.9   356.1   361.4   364.8   369.6   373.4   381.1
  46    134   327.4   354.2   358.2   373.9   374.9   392.3   396.1   397.8   401.7   398.3   389.4   404.4   411.3
  46    135   323.7   341.1   349.0   360.7   367.0   378.9   377.8   374.1   378.1   376.5   377.7   382.7   444.1
  46    136   340.0   366.3   374.1   390.2   399.8   411.4   419.9   420.4   422.0   426.2   432.2   433.9   388.7
  47    137   329.4   345.6   359.2   373.0   378.2   385.7   385.2   388.7   385.0   377.9   391.0   386.1   379.7
  47    138   331.1   346.1   361.7   377.7   384.0   392.9   392.6   396.9   395.2   333.0   398.1   408.0   410.8
  47    139   318.6   337.1   350.1   365.1   375.3   384.1   388.4   388.2   384.4   378.4   392.7   398.1   404.4
  48    140   310.8   336.6   349.5   356.5   364.1   374.0   372.9   378.8   306.6   350.2   380.8   386.0   397.9
  48    141   316.3   342.5   358.6   372.7   384.8   401.3   403.3   399.6   307.1   371.5   408.5   417.5   425.9
  48    142   324.2   350.8   366.8   373.9   385.4   396.7   392.7   395.6   364.5   382.5   402.9   406.8   412.6
  49    143   315.0   336.3   351.5   362.4   369.1   378.7   377.7   385.4   393.6   389.9   394.8   403.1   408.8
  49    144   319.5   340.1   353.0   363.9   378.9   388.6   388.2   389.9   399.7   389.6   402.0   404.0   411.7
  49    145   314.7   348.5   361.8   375.2   383.7   395.1   389.5   399.0   404.2   391.8   404.9   407.1   408.2
  50    146   316.5   335.4   345.1   354.8   365.4   372.3   374.1   380.3   383.5   389.5   386.1   390.9   400.1
  50    147   322.6   340.8   351.9   362.4   362.7   374.5   376.8   376.1   376.1   383.5   382.6   384.2   390.8

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 41
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 1250 PPM           TRT#:  5         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       117     145     173     201     229     257     285     313     341     369     397     425     453
----------------------------------------------------------------------------------------------------------------------------------

  50    148   291.6   313.1   320.8   332.9   333.1   343.6   346.2   349.4   359.6   359.4   361.8   359.7   370.2
  51    149   338.7   353.4   364.0   372.1   382.6   386.9   394.2   402.1   401.2   405.4   399.9   405.1   407.4
  51    150   347.6   366.7   365.8   377.0   386.7   394.5   394.3   403.7   403.3   400.6   398.9   406.3   414.1
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    322.2   340.3   350.9   363.2   369.8   379.4   379.7   383.8   385.0   385.7   390.1   395.7   395.6

SD             15.0    15.1    15.8    16.6    18.4    17.9    18.7    17.9    24.0    20.0    18.8    18.8    25.6

NO. OBSER.       50      50      50      50      50      50      50      50      50      50      50      50      50

AVE. BODY WT
REL. TO CNTL   0.88    0.89    0.89    0.88    0.89    0.89    0.89    0.89    0.88    0.88    0.89    0.89    0.88
(TRT#:    1 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 42
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 1250 PPM           TRT#:  5         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       481     509     537     565     593     621     649     677     705
----------------------------------------------------------------------------------------------------------------------------------

  35    101   392.4   390.2   394.6   379.6   361.8   389.9   385.2   388.2   386.6
  35    102   396.8   389.5   393.6   382.9   380.8   390.3   389.4   389.6   383.8
  35    103   405.3   398.6   400.0   400.2   389.6   393.1   389.4   363.5 @
  36    104   381.3   374.5   381.2   307.8   387.9   383.6   382.1   374.1   376.4
  36    105   417.2   403.8   408.0   357.4   401.4   372.2 @
  36    106   387.6   372.2   381.3   266.9   367.8   372.1   368.3   364.1   360.6
  37    107   429.4   421.1   425.7   426.2   414.4   405.0   407.4   402.7   399.0
  37    108   406.3   403.2   404.9   412.1   412.4   404.8   404.3   412.0   414.5
  37    109   390.4   382.1   386.0   388.8   322.4 @
  38    110   387.2   372.4   342.3 @
  38    111   366.2   363.1   361.1   301.1   355.1   345.9   351.3   346.6   330.6
  38    112   416.6   414.3   415.7   403.5   411.9   397.8   398.0   398.8   389.5
  39    113   497.9 @
  39    114   414.0   404.3   407.4   388.3   337.5 @
  39    115   380.9   371.3   375.0   364.1   366.4   338.5 @
  40    116   397.0   382.5   392.3   382.3   373.7   380.4   377.4   377.2   349.5 @
  40    117   410.8   400.7   411.9   401.5   409.7   412.1   414.7   413.1   417.8
  40    118   390.2   380.9   391.9   378.3   387.2   384.4   383.9   386.1   385.3
  41    119   379.7   381.6   380.4   380.3   381.0   371.3   375.2   376.1   367.5
  41    120   404.0   404.2   403.7   400.8   404.1   400.5   403.9   408.7   400.8
  41    121   365.4   370.1   371.0   369.9   374.9   371.9   366.0   373.5   365.5
  42    122   402.6   406.2   406.1   397.2   385.7   369.0   283.6 @
  42    123   392.0   392.0   398.9   393.1   392.5   384.9   387.7   387.9   376.2
  42    124   379.5   375.3   367.6   357.3   367.3   362.6   373.5   371.1   339.7 @
  43    125   370.5   370.1   370.0   372.3   373.7   365.8   364.1   356.5   331.3
  43    126   375.0   374.0   367.6   363.5   356.9   326.0   275.7 @
  43    127   377.5   369.8   372.5   373.3   376.3   383.2   403.1   443.9 @
  44    128   404.1   406.1   409.3   398.5   396.3   398.1   396.4   394.0   391.4
  44    129   409.3   407.8   411.1   404.8   409.6   408.3   407.1   406.8   400.7
  44    130   453.2   437.1   443.3   435.3   436.5   425.4   412.4   404.8   399.6
  45    131   443.1   433.4   436.7   433.4   432.5   430.7   432.7   428.9   424.2
  45    132   410.1   412.1   404.8   406.5   396.8   390.9   391.7   388.9   381.1
  45    133   387.9   379.3   381.2   379.1   378.3   377.2 @
  46    134   413.8   408.2   406.1   396.8   395.4   376.1   370.6   366.1   328.4 @
  46    135   384.6   382.9   379.7   375.6   376.4   374.1   374.8   375.4   352.7
  46    136   448.1   445.0   436.0   424.4   432.9   430.5   414.0   417.0   403.0
  47    137   380.1   377.5   375.7   371.6   368.5   372.7   367.2   373.0   362.4
  47    138   412.1   408.3   405.4   406.6   402.3   398.7   390.5   401.0   385.9
  47    139   407.5   404.0   406.1   402.4   401.8   403.2   395.4   396.6   394.1
  48    140   400.1   398.9   395.4   394.4   396.7   387.7   392.5   395.0   391.6
  48    141   420.6   413.2   412.2   404.7   407.9   401.8   399.0   404.4   403.3
  48    142   412.5   407.0   403.5   399.8   393.0   389.5   383.5   382.7   372.2
  49    143   401.5   405.3   395.7   399.8   390.7   396.1   389.8   383.2   360.8
  49    144   408.2   402.7   409.3   410.0   402.1   404.6   395.7   394.1   389.5
  49    145   384.5 @
  50    146   406.9   398.9   401.3   409.3   405.3   394.7   395.5   289.3 @
  50    147   395.3   394.4   395.2   399.2   389.4   383.6   379.3   288.5   371.9

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 43
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 1250 PPM           TRT#:  5         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       481     509     537     565     593     621     649     677     705
----------------------------------------------------------------------------------------------------------------------------------

  50    148   369.7   369.2   371.2   373.2   370.4   366.7   363.6   258.2   343.1
  51    149   415.3   413.9   404.0   401.4   393.1   388.4   367.6   386.4   380.7
  51    150   412.5   404.3 @
              -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    401.9   395.4   395.6   386.4   388.4   386.5   383.0   381.2   378.1

SD             24.1    19.2    20.5    31.7    23.0    21.4    29.1    36.0    24.8

NO. OBSER.       50      48      47      46      46      44      41      39      36

AVE. BODY WT
REL. TO CNTL   0.90    0.89    0.90    0.88    0.90    0.92    0.90    0.90    0.94
(TRT#:    1 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 44
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 2500 PPM           TRT#:  7         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      12      19      26      33      40      47      54      61      68      75      82      89
----------------------------------------------------------------------------------------------------------------------------------

  52    151   107.2    21.9   170.7   203.3   219.7   238.4   251.6   269.0   279.4   289.4   286.3   290.9   300.0
  52    152    99.6   133.5   157.2   181.2   198.9   212.3   225.5   241.8   249.7   261.2   264.0   267.6   263.6
  52    153   126.4   162.0   190.3   219.0   242.2   258.5   276.9   286.4   294.4   306.4   309.3   312.8   317.1
  53    154   128.7   162.0   188.5   213.7   228.6   246.0   261.6   276.1   288.6   294.8   296.1   308.3   309.2
  53    155    99.8   129.2   153.6   176.2   193.1   208.1   214.7   227.9   234.0   242.3   242.6   249.7   251.4
  53    156   128.0   160.9   189.1   215.6   231.6   246.8   260.3   275.1   282.5   291.0   291.4   295.8   297.6
  54    157   122.4   148.0   180.4   208.3   226.8   245.8   260.6   274.6   280.2   293.1   298.9   304.1   304.2
  54    158   116.2   148.7   177.2   201.6   220.1   240.2   250.2   267.1   274.0   282.4   286.9   287.8   289.8
  54    159   109.1   135.8   163.1   190.8   205.0   225.7   236.4   250.3   259.5   263.1   262.9   267.3   265.2
  55    160   115.0   147.2   171.6   201.8   222.1   234.4   251.1   265.7   277.9   285.7   291.8   297.9   294.0
  55    161   109.0   133.8   159.1   187.0   208.6   221.3   226.6   233.6   243.0   247.7   250.7   258.4   257.8
  55    162   136.6   168.6   191.7   220.4   235.4   250.4   262.1   274.9   280.7   287.6   286.5   287.8   288.7
  56    163   123.4   150.8   178.2   203.8   224.5   243.7   257.0   273.3   278.9   289.4   291.3   292.1   289.1
  56    164   133.7   168.0   196.4   219.2   233.9   249.0   262.3   274.3   282.0   287.6   288.2   289.8   271.2
  56    165   121.5   147.1   169.8   193.7   215.7   233.8   248.7   263.6   275.7   285.7   290.3   299.7   295.9
  57    166   137.0   164.6   187.5   212.3   229.8   246.6   256.2   269.5   279.1   289.6   294.6   297.8   291.9
  57    167   113.4   143.3   168.6   199.2   215.7   234.2   246.6   259.3   267.0   274.6   273.1   276.3   273.8
  57    168   112.9   145.8   173.9   199.0   215.9   233.5   247.8   260.2   269.3   282.6   282.0   285.4   281.7
  58    169   135.2   162.7   191.9   215.0   230.3   243.2   251.8   261.5   271.0   279.9   280.4   285.1   285.0
  58    170   130.7   162.4   187.6   207.9   225.1   237.7   245.8   257.3   265.1   275.6   276.6   283.9   287.2
  58    171   129.1   161.4   190.1   212.9   230.8   244.7   251.6   261.9   268.4   276.0   278.8   282.7   280.2
  59    172   135.2   164.4   196.5   217.1   236.0   249.6   261.8   273.2   280.3   291.0   292.8   303.1   300.8
  59    173   132.4   156.9   183.0   211.0   227.7   242.0   252.8   264.1   272.5   279.2   281.5   289.2   292.6
  59    174   132.9   160.4   186.8   210.4   229.0   247.5   254.0   266.5   272.6   276.7   278.2   285.6   281.3
  60    175   115.4   141.9   169.2   192.7   206.6   218.1   227.6   241.4   250.9   256.7   265.6   269.8   267.9
  60    176   119.0   145.5   175.7   194.5   213.0   233.4   243.4   250.2   256.2   259.4   263.2   262.1   265.4
  60    177   118.2   147.2   174.9   197.9   216.1   235.2   243.6   253.0   254.1   254.6   257.5   261.4   263.1
  61    178   140.5   169.9   199.8   227.8   243.4   258.5   268.1   276.7   287.2   289.6   294.3   296.1   297.4
  61    179   131.4   154.8   185.6   210.1   227.8   244.3   258.3   268.9   281.3   288.9   292.6   299.1   300.2
  61    180   132.1   158.1   188.2   215.9   237.0   251.3   262.5   270.6   277.9   276.2   278.2   282.1   281.7
  62    181   114.3   135.6   158.1   180.7   195.1   211.5   220.9   228.1   237.7   243.1   246.8   248.7   249.4
  62    182   136.0   165.5   195.0   219.8   236.6   254.8   264.3   274.4   284.0   294.5   298.6   306.1   311.1
  62    183   116.9   146.7   173.6   197.2   215.2   231.9   243.6   252.8   262.8   270.3   272.9   281.9   284.2
  63    184   127.2   155.0   183.1   210.2   229.9   246.2   258.9   267.7   273.4   280.2   277.9   281.4   279.5
  63    185   130.9   157.3   183.9   206.2   224.7   239.4   248.1   257.4   264.2   269.6   273.7   276.9   276.3
  63    186   107.4   138.4   168.9   194.7   216.5   232.4   249.3   257.7   271.0   281.9   284.4   293.5   293.4
  64    187   111.4   138.8   156.8   183.9   201.8   223.1   235.9   247.2   254.5   263.6   270.9   278.0   273.6
  64    188   128.5   158.1   183.8   209.0   227.4   240.0   252.4   265.6   273.2   284.9   282.6   286.5   280.8
  64    189   137.2   161.9   190.9   213.6   228.8   242.9   255.8   265.8   272.5   282.2   284.9   291.1   286.0
  65    190   112.9   139.0   168.5   193.1   215.8   228.7   241.1   253.6   264.2   273.3   278.6   285.5   286.4
  65    191   120.6   145.1   173.8   196.8   214.8   227.4   237.9   252.6   259.2   263.5   263.2   266.2   265.5
  65    192   136.9   161.7   183.0   208.4   227.4   242.0   254.4   269.8   275.2   280.1   284.4   290.1   286.6
  66    193   117.6   146.0   175.5   199.7   215.9   235.6   248.5   260.0   271.3   280.8   284.0   290.6   288.0
  66    194   128.4   156.1   185.4   207.6   224.0   238.5   250.0   263.0   271.5   278.6   279.9   287.7   286.4
  66    195   145.4   170.6   196.8   219.3   234.3   251.1   265.1   275.8   281.3   292.9   292.2   292.5   290.2
  67    196   122.4   154.1   182.7   204.7   221.0   238.6   250.5   261.2   268.5   272.5   275.7   278.6   277.0
  67    197   132.3   165.3   191.8   215.1   230.7   245.1   257.5   266.7   274.4   281.3   284.5   289.3   289.9

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 45
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 2500 PPM           TRT#:  7         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID         1      12      19      26      33      40      47      54      61      68      75      82      89
----------------------------------------------------------------------------------------------------------------------------------

  67    198   135.8   159.6   186.2   208.5   223.1   237.6   250.0   260.6   263.9   269.0   269.7   273.2   266.6
  68    199   121.8   149.5   180.1   205.1   224.6   241.7   253.6   262.7   273.6   279.8   281.8   284.2   282.1
  68    200   135.0   165.8   191.9   219.4   236.8   251.7   265.4   272.1   280.1   289.2   284.0   286.2   283.4
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    124.2   150.5   180.1   205.0   222.7   238.7   250.4   262.1   270.2   277.8   279.9   284.8   283.6

SD             11.0    21.5    11.8    11.7    11.6    11.5    12.4    12.5    12.7    13.8    13.6    14.1    14.7

NO. OBSER.       50      50      50      50      50      50      50      50      50      50      50      50      50

AVE. BODY WT
REL. TO CNTL   1.00    0.84    0.86    0.85    0.87    0.88    0.88    0.86    0.86    0.86    0.85    0.83    0.82
(TRT#:    1 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 46
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 2500 PPM           TRT#:  7         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       117     145     173     201     229     257     285     313     341     369     397     425     453
----------------------------------------------------------------------------------------------------------------------------------

  52    151   311.7   329.4   336.5   350.7   356.2   358.3   369.6   366.3   365.8   371.2   366.7   366.7   372.3
  52    152   281.9   296.9   306.2   325.8   329.0   335.2   345.4   346.1   351.9   357.6   356.5   357.5   363.0
  52    153   329.8   349.6   359.8   373.3   381.1   383.7   388.2   390.8   389.7   399.8   402.2   399.9   404.3
  53    154   270.6   336.0   344.6   365.6   361.6   376.6   380.1   377.1   384.0   375.4   368.0   378.7   383.6
  53    155   230.6   283.2   294.8   312.6   312.4   321.0   325.6   324.8   328.4   330.8   327.0   334.8   345.0
  53    156   284.3   327.0   337.2   350.9   358.7   365.6   370.1   369.4   372.2   376.1 @
  54    157   322.5   336.3   352.8   366.6   364.4   346.9   379.3   372.2   382.5   382.2   380.2   391.6   395.9
  54    158   292.5   326.3   338.2   345.7   351.4   314.3   362.4   360.5   365.0   364.2   360.3   368.8   372.7
  54    159   280.2   296.8   309.0   315.3   325.5   288.4   344.3   340.3   349.0   353.7   347.4   359.9   364.5
  55    160   289.2   309.8   323.8   333.0   337.0   341.3   342.3   349.0   352.7   355.4   355.9   366.7   368.8
  55    161   263.7   291.2   297.5   306.3   313.0   320.9   316.7   323.8   329.4   334.1   330.0   336.9   340.6
  55    162   271.7   304.5   316.2   327.1   332.2   336.7   343.6   353.1   357.2   357.3   356.2   365.7   379.0
  56    163   302.1   315.9   330.8   347.9   360.6   358.6   359.7   361.5   363.3   367.9   371.6   375.2   378.7
  56    164   303.6   321.0   329.4   345.9   351.7   353.8   357.2   363.0   364.6   364.7   370.6   369.0   371.7
  56    165   300.8   309.1   325.6   345.3   349.2   353.9   358.1   359.2   363.5   358.2   365.5   367.0   372.0
  57    166   278.3   331.5   328.7   342.7   350.4   350.9   360.3   360.0   362.4   366.7   368.6   369.5   369.5
  57    167   287.1   314.7   311.8   333.2   340.6   333.7   338.8   335.8   332.8   339.7 @
  57    168   290.3   316.9   327.0   348.4   352.3   361.3   373.7   372.0   372.6   383.7   381.9   388.7   385.3
  58    169   294.6   312.0   328.2   341.8   345.8   347.3   347.7   358.2   361.9   359.2   361.1   360.5   364.6
  58    170   290.0   305.7   315.3   323.0   330.9   338.2   345.2   352.5   355.4   357.6   355.9   350.4   360.5
  58    171   290.7   305.0   314.2   332.0   339.9   344.3   354.9   357.5   360.0   360.4   350.0   362.9   364.2
  59    172   319.6   331.8   344.0   357.9   361.1   371.8   369.1   381.9   387.1   390.0   385.2   392.7   397.0
  59    173   306.9   319.5   332.2   351.8   353.2   364.4   363.4   366.0   369.2   367.9   367.0   378.3   384.1
  59    174   306.9   315.4   326.7   348.2   351.2   358.4   327.5   359.4   365.2   367.8   368.2   368.2   368.9
  60    175   281.3   295.8   311.3   327.9   332.8   338.6   337.0   342.0   347.4   349.7   349.1   359.9   347.4
  60    176   290.8   306.4   319.7   334.3   337.9   341.4   338.8   344.0   354.3   353.1   358.6   364.8   361.6
  60    177   290.9   302.0   309.3   328.1   325.0   333.5   327.8   336.0   340.9   340.6   341.0   349.5   347.0
  61    178   299.0   321.2   333.7   343.2   342.0   360.7   356.9   363.9   371.8   374.9   370.1   377.4   372.9
  61    179   311.4   323.3   336.0   341.1   342.3   355.3   356.4   362.5   366.2   366.6   370.3   377.5   374.1
  61    180   307.8   317.4   330.5   344.6   333.4   347.5   344.4   354.8   357.5   364.9   360.9   364.7   367.2
  62    181   271.0   286.4   295.8   304.5   308.1   314.8   318.6   325.8   330.9   330.0   339.1   346.0   345.5
  62    182   312.6   335.8   343.8   322.2   355.8   363.9   371.7   374.8   380.9   382.1   394.0   390.3   390.3
  62    183   287.7   313.9   322.0   328.1   328.3   330.2   325.8   328.3   333.6   328.9   337.7   340.1   340.0
  63    184   293.4   309.1   322.7   337.3   346.1   338.4   347.3   357.0   360.3   361.4   366.9   373.4   367.2
  63    185   294.8   306.1   305.9   321.0   330.2   325.6   332.5   331.1   333.5   337.3   337.1   335.1   332.7
  63    186   306.9   324.7   333.0   344.9   353.1   352.0   360.1   364.0   364.2   367.1   374.4   383.7   381.9
  64    187   281.9   302.9   319.9   325.7   331.8   336.1   341.9   349.0   354.0   355.2   354.5   361.1   363.6
  64    188   279.3   306.8   322.0   333.1   332.5   337.3   344.4   347.8   355.8   350.0   355.9   356.2   362.4
  64    189   290.3   309.1   328.1   330.6   336.6   342.8   348.7   354.3   354.1   354.2   346.9   350.4   354.8
  65    190   300.0   309.8   324.7   339.7   346.0   345.6   355.1   358.3   364.7   365.1   366.6   365.7   372.9
  65    191   278.8   300.3   307.0   312.3   311.3   317.7   325.2   329.2   327.3   330.2   329.5   330.9   336.4
  65    192   294.6   311.6   328.3   334.4   337.7   335.2   345.5   346.2   355.9   363.1   363.7   363.8   369.1
  66    193   297.1   301.1   314.3   330.2   330.0   337.1   343.9   351.0   342.2   351.8   348.0   351.2   357.6
  66    194   300.2   312.6   323.4   338.7   336.3   342.4   344.3   344.6   349.9   355.1   350.8   361.0   359.6
  66    195   284.2   299.9   312.8   332.4   337.4   342.5   348.8   351.3   351.9   354.1   351.0   363.8   366.1
  67    196   299.3   318.4   314.4   331.4   335.2   338.0   344.9   347.7   352.7   348.3   353.2   361.3   367.0
  67    197   305.4   318.8   316.4   327.3   330.5   329.9   341.6   341.1   346.9   344.9   354.3   362.8   365.4

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 47
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 2500 PPM           TRT#:  7         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       117     145     173     201     229     257     285     313     341     369     397     425     453
----------------------------------------------------------------------------------------------------------------------------------

  67    198   282.6   301.6   304.7   322.6   324.8   328.2   335.3   341.0   344.2   340.2   340.5   346.3   349.6
  68    199   289.1   308.9   320.5   333.3   334.5   340.0   348.3   351.5   359.8   357.2   360.6   363.2   366.0
  68    200   262.1   317.0   326.7   335.1   327.8   336.8   341.5   348.6   353.3   355.1   354.3   360.3   362.4
              -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    291.8   312.9   323.1   335.9   339.9   342.7   349.0   352.9   356.8   358.5   358.9   364.0   366.4

SD             16.9    13.5    13.9    14.5    14.9    17.3    16.1    15.0    15.2    15.7    15.8    15.5    15.5

NO. OBSER.       50      50      50      50      50      50      50      50      50      50      48      48      48

AVE. BODY WT
REL. TO CNTL   0.80    0.82    0.82    0.82    0.81    0.80    0.81    0.82    0.82    0.82    0.82    0.82    0.82
(TRT#:    1 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 48
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 2500 PPM           TRT#:  7         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       481     509     537     565     593     621     649     677     705
----------------------------------------------------------------------------------------------------------------------------------

  52    151   372.8   366.5   369.9   374.4   355.9   222.2 @
  52    152   365.5   355.5   358.3   366.5   355.1   349.0   324.4   257.4 @
  52    153   410.6   398.6   400.1   403.9   386.2   387.0   391.4   383.6   367.3
  53    154   383.5   381.4   376.3   370.9   363.6   363.3   279.3 @
  53    155   347.2   340.8   338.3   335.0   336.7   339.0   339.5   319.9   312.2
  53    156
  54    157   392.8   389.6   388.6   388.0   385.3   383.1   383.3   385.4   378.3
  54    158   366.1   367.4   344.6   358.8   356.6   356.9   353.1   353.4   341.8
  54    159   357.7   366.7   338.6   360.9   354.6   355.5   346.6   353.8   349.9
  55    160   363.2   364.8   350.4   353.3   355.5   347.5   343.8   359.0   346.2
  55    161   343.8   340.3   334.9   338.3   334.5   333.3   335.1   337.9   336.1
  55    162   373.2   373.1   365.4   373.1   369.6   363.8   364.8   375.1   370.4
  56    163   377.5   376.9   370.4   380.1   381.0   379.6   375.5   365.3   360.1
  56    164   369.4   369.7   359.4   368.3   360.4   353.9   351.7   347.6   336.3
  56    165   369.7   371.3   368.4   376.6   377.4   367.8 @
  57    166   347.1   371.9   361.5   367.7   359.5   342.0   333.8   324.7 @
  57    167
  57    168   346.8   380.3   384.1   387.4   369.9 @
  58    169   371.2   361.7   364.2   365.1   361.5   360.8   359.1   297.5   342.4
  58    170   367.4   359.2   358.3   352.7   346.5   346.6   349.0   288.2   332.9
  58    171   369.1   365.5   366.4   370.5   366.1   367.2   371.9 @
  59    172   400.8   394.3   398.2   395.3   390.6   391.9   390.9   398.4   390.7
  59    173   386.5   379.0   385.4   375.5   372.3   378.1   369.9   375.2   362.7
  59    174   377.3   373.6   378.1   368.2   367.5   363.5   364.5   365.2   357.9
  60    175   360.2   361.6   362.3   252.0 @
  60    176   359.9   367.6   367.4   363.7   357.9   353.3   350.9   346.4   339.8
  60    177   347.6   348.5   346.2   338.6   337.3   339.0   338.2   337.6   327.5
  61    178   377.3   379.5   378.7   375.4   376.7   375.6   366.9   365.4   354.9
  61    179   380.2   377.2   383.1   377.7   380.0   376.8   376.4   376.3   368.7
  61    180   368.1   370.6   379.8   367.9   359.3   361.7   254.7 @
  62    181   344.5   345.9   347.1   345.7   341.0   312.8   281.8 @
  62    182   389.5   389.4   387.1   389.4   394.4   387.5   358.7 @
  62    183   342.8   341.5   350.4   347.7   353.1   344.5   344.8   328.1   322.6
  63    184   382.8   375.1   380.8   380.5   376.0   374.6   380.6   365.4   365.3
  63    185   348.7   346.0   344.2   341.0   338.0   336.3   334.1   330.1   321.7
  63    186   395.6   395.2   394.4   392.8   390.4   395.2   393.9   388.5   379.1
  64    187   365.3   360.9   365.9   362.9   380.4   386.7 @
  64    188   364.3   367.4   370.4   365.0   362.0   365.6   353.0   347.8   343.5
  64    189   360.4   355.1   360.0   355.9   347.4   263.2 @
  65    190   371.2   369.3   372.2   374.8   369.8   362.2   366.7   369.2   359.3
  65    191   329.0   333.4   343.8   345.3   339.0   331.5   331.0   331.6   325.1
  65    192   372.3   369.9   375.9   377.1   372.3   370.5   366.0   373.7   362.2
  66    193   356.9   357.0   357.6   356.0   358.8   349.1   345.1   355.7   340.7
  66    194   363.2   359.8   337.5   363.8   361.8   354.0   325.6 @
  66    195   359.5   367.2   353.6   365.1   356.1   359.5   357.8   365.4   358.6
  67    196   370.4   364.3   365.5   361.9   363.2   356.3   352.9   350.8   346.6
  67    197   371.9   363.0   371.2   370.5   362.8   353.7   355.9   365.5   354.4

NTP  EXP/TEST: 92013-05                                4-METHYLIMIDAZOLE                                          PAGE: 49
TEST TYPE: CHRONIC                               INDIVIDUAL BODY WEIGHT TABLE                                     DATE: 11/29/04
ROUTE: DOSED FEED                                           EISRPT12                                              TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                SEX: MALE     TRT: 2500 PPM           TRT#:  7         FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL                                             DAY ON DOSE
 NO    ID       481     509     537     565     593     621     649     677     705
----------------------------------------------------------------------------------------------------------------------------------

  67    198   350.9   347.3   347.2   346.6   340.7   326.4   306.1 @
  68    199   364.4   360.5   357.4   358.6   346.9   344.9   336.3   299.4 @
  68    200   366.1   358.7   360.1   360.3   357.6   353.7   350.8   354.9   332.8
              -----   -----   -----   -----   -----   -----   -----   -----   -----
MEAN WT(G)    367.1   366.3   365.0   363.9   362.3   354.1   348.9   349.7   349.6

SD             16.2    14.7    16.5    22.6    15.5    30.3    29.1    30.4    18.6

NO. OBSER.       48      48      48      48      47      46      42      35      32

AVE. BODY WT
REL. TO CNTL   0.82    0.83    0.83    0.83    0.84    0.84    0.82    0.83    0.87
(TRT#:    1 )

BLANK   MISSING DATA                                              @   ANIMAL REMOVED FROM STUDY
()      TRT# OF THE CONTROL GROUP USED IN CALCULATION             *   MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED

                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.