National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17685

TDMS Study 92013-05 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst                            4-METHYLIMIDAZOLE                                            DATE: 11/29/04  
EXPERIMENT: 92013 TEST: 05                                                                                        TIME: 09:47:08    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C92013B     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: SOUTHERN RESEARCH INSTITUTE                      4-METHYLIMIDAZOLE                                           DATE: 11/29/04    
EXPERIMENT: 92013 TEST: 05                                                                                        TIME:  9:55:46    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  92013B      
CONT: N01-ES-85420                                                                                                CAS: 822-36-6     
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                         
                                             CHRONIC DOSED FEED STUDY OF 4-METHYLIMIDAZOLE                                          
==================================================================================================================================  
           0 PPM                      625 PPM                            1250 PPM                           2500 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1    17.5   124.2      16.3    123.6    0.93       82     14.5    123.0    0.83      147     11.7    124.2    0.67      235       
  2    17.2   179.2      17.1    173.4    0.99       62     16.3    165.1    0.95      124     15.6    150.5    0.91      259       
  3    19.2   209.8      18.6    204.5    0.97       57     17.3    193.4    0.90      112     15.8    180.1    0.82      219       
  4    19.4   240.4      18.5    234.8    0.95       49     17.3    221.4    0.89       97     16.2    205.0    0.84      198       
  5    19.4   255.0      19.4    250.2    1.00       49     18.3    237.3    0.94       96     16.6    222.7    0.86      186       
  6    18.5   269.7      18.0    266.0    0.97       42     17.3    252.3    0.94       86     16.1    238.7    0.87      168       
  7    18.8   285.9      17.6    279.8    0.94       39     16.9    264.5    0.90       80     15.8    250.4    0.84      158       
  8    17.8   304.2      17.3    297.2    0.97       36     16.4    280.1    0.92       73     15.2    262.1    0.85      145       
  9    17.6   313.3      16.9    306.8    0.96       34     15.6    288.2    0.89       68     15.0    270.2    0.85      139       
 10    17.9   324.3      17.3    317.2    0.97       34     15.7    295.1    0.88       66     14.9    277.8    0.83      134       
 11    17.8   329.6      16.4    321.0    0.92       32     15.2    296.7    0.85       64     14.4    279.9    0.81      129       
 12    17.7   341.7      16.2    330.6    0.92       31     15.0    303.8    0.85       62     14.4    284.8    0.81      127       
 13    17.4   345.3      16.6    331.7    0.95       31     15.0    303.2    0.86       62     14.2    283.6    0.82      125       
 17    17.8   365.2      16.9    352.4    0.95       30     15.6    322.2    0.88       60     14.1    291.8    0.79      121       
 21    18.9   382.3      17.2    367.5    0.91       29     16.9    340.3    0.89       62     16.1    312.9    0.85      129       
 25    18.0   395.3      16.4    382.5    0.91       27     15.7    350.9    0.87       56     14.6    323.1    0.81      113       
 29    18.4   410.4      17.7    395.7    0.96       28     16.3    363.2    0.89       56     15.7    335.9    0.85      117       
 33    17.5   417.5      17.2    402.3    0.98       27     15.6    369.8    0.89       53     14.7    339.9    0.84      108       
 37    17.7   425.9      16.7    408.0    0.94       26     15.9    379.4    0.90       52     15.8    342.7    0.89      115       
 41    17.0   428.8      16.9    414.6    0.99       25     16.9    379.7    0.99       55     15.3    349.0    0.90      110       
 45    17.1   432.7      16.7    419.0    0.98       25     15.4    383.8    0.90       50     14.8    352.9    0.87      105       
 49    17.1   437.3      16.9    421.4    0.99       25     15.5    385.0    0.91       50     15.4    356.8    0.90      108       
 53    16.5   439.5      16.2    428.9    0.98       24     15.1    385.7    0.92       49     14.4    358.5    0.87      100       
 57    17.1   437.9      16.6    424.5    0.97       24     15.5    390.1    0.91       50     15.3    358.9    0.89      107       
 61    17.9   444.7      16.9    428.1    0.94       25     15.8    395.7    0.88       50     15.2    364.0    0.85      105       
 65    16.6   448.0      16.1    435.0    0.97       23     15.9    395.6    0.96       50     15.3    366.4    0.92      104       
 69    16.5   445.3      15.3    430.2    0.93       22     15.1    401.9    0.92       47     16.3    367.1    0.99      111       
 73    16.6   443.5      16.0    423.9    0.96       24     15.3    395.4    0.92       48     14.4    366.3    0.87       98       
 77    15.8   438.3      16.1    424.6    1.02       24     14.8    395.6    0.94       47     15.9    365.0    1.01      109       
 81    15.5   437.8      14.9    419.1    0.96       22     14.4    386.4    0.93       46     14.7    363.9    0.95      101       
 85    15.6   432.8      15.2    416.1    0.97       23     14.6    388.4    0.94       47     14.4    362.3    0.92       99       
 89    14.9   421.2      14.1    408.3    0.95       22     14.2    386.5    0.95       46     13.9    354.1    0.93       98       
 93    15.9   425.8      16.9    414.4    1.06       25     13.9    383.0    0.87       45     12.3    348.9    0.77       88       
 97    16.4   422.1      15.8    408.2    0.96       24     15.3    381.2    0.93       50     14.7    349.7    0.90      105       
==================================================================================================================================  
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                         
                                             CHRONIC DOSED FEED STUDY OF 4-METHYLIMIDAZOLE                                          
==================================================================================================================================  
           0 PPM                      625 PPM                            1250 PPM                           2500 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
101    15.3   400.2      14.1    405.2     0.92      22     14.4    378.1     0.94      48     15.0    349.6     0.98     107       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   18.2   271.0      17.4    264.4     0.96      45     16.2    248.0     0.89      87     15.1    233.1     0.83     171       
SD(D)   0.8               1.0              0.03      15      1.2              0.04      27      1.3              0.06      45       
CV(E)   4.3               5.8              2.7     33.9      7.2              4.2     30.7      8.3              6.6     26.2       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   17.7   410.6      16.9    395.9     0.96      27     16.0    363.8     0.90      55     15.2    333.9     0.86     114       
SD(D)   0.6               0.4              0.03       2      0.6              0.04       4      0.7              0.04       8       
CV(E)   3.7               2.2              3.3      6.9      3.7              4.0      7.6      4.3              4.5      6.6       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   16.2   433.6      15.7    420.5     0.97      23     14.9    389.5     0.92      48     14.8    359.6     0.91     103       
SD(D)   0.8               0.9              0.04       1      0.6              0.02       2      1.0              0.06       6       
CV(E)   5.0               6.0              3.9      5.1      4.3              2.7      3.6      6.7              7.0      5.8       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                       
                                             CHRONIC DOSED FEED STUDY OF 4-METHYLIMIDAZOLE                                          
==================================================================================================================================  
           0 PPM                      1250 PPM                           2500 PPM                           5000 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1    12.7   100.1      11.1     97.9     0.87     142      8.8     99.5     0.69     221      5.5     99.0     0.43     278       
  2    12.1   127.4      12.1    124.2     1.00     122     11.7    118.3     0.97     247      9.6     96.0     0.79     499       
  3    12.4   138.4      12.4    137.0     1.00     113     11.4    132.8     0.92     216     10.1    109.3     0.81     461       
  4    12.2   148.7      11.5    148.1     0.94      97     11.3    143.5     0.93     197      9.0    117.9     0.74     381       
  5    11.9   155.5      11.6    154.9     0.97      94     11.0    152.3     0.92     181      9.4    125.8     0.79     374       
  6    11.6   163.1      11.2    161.9     0.97      87     10.9    161.1     0.94     169      9.4    132.4     0.81     357       
  7    11.8   168.7      10.7    166.0     0.91      80     11.3    166.3     0.96     170      9.6    136.8     0.81     349       
  8    11.3   176.0      10.4    172.4     0.92      75     10.3    171.8     0.91     149      9.3    141.6     0.82     329       
  9    11.0   177.2      10.2    173.4     0.93      73     10.2    174.6     0.93     145      8.7    143.3     0.79     305       
 10    11.1   181.6       9.8    175.6     0.88      70      9.9    178.2     0.89     139      8.6    145.2     0.77     296       
 11    10.9   185.8       9.8    178.3     0.90      69      9.6    179.9     0.88     134      8.3    146.1     0.76     284       
 12    10.7   186.5       9.6    179.6     0.90      67      9.1    180.5     0.85     126      8.3    148.5     0.78     279       
 13    10.8   189.7       9.9    182.1     0.92      68      9.0    181.0     0.83     124      9.4    151.7     0.87     311       
 17    11.0   194.4      10.1    188.9     0.92      67      9.5    188.9     0.86     126      8.7    153.8     0.79     283       
 21    11.8   203.9      10.2    194.4     0.86      66      9.9    193.3     0.84     128      8.3    157.7     0.70     265       
 25    11.2   211.8       9.7    202.4     0.87      60      9.5    201.6     0.85     118      8.3    163.9     0.74     254       
 29    11.4   217.3      10.4    208.8     0.91      62      9.3    202.8     0.82     115      8.7    166.7     0.76     261       
 33    11.8   223.1      10.8    214.9     0.92      63      9.0    209.0     0.76     108      8.6    171.8     0.73     252       
 37    12.3   228.5       9.8    218.3     0.80      56     10.0    214.5     0.81     116      8.7    173.9     0.71     252       
 41     9.6   227.7      10.2    220.3     1.06      58      9.7    216.3     1.01     112      9.1    177.5     0.95     256       
 45    11.1   238.4       9.8    223.4     0.88      55      9.3    217.4     0.84     107      8.8    178.9     0.79     246       
 49    11.7   242.4      10.2    227.3     0.87      56      9.7    221.4     0.83     109      9.1    183.3     0.78     248       
 53    11.3   250.6       9.1    231.9     0.81      49      9.1    223.5     0.81     101      8.6    186.6     0.76     231       
 57    12.5   254.7       9.8    234.1     0.78      52      9.7    224.1     0.78     108      9.3    187.4     0.74     248       
 61    12.3   270.1      10.2    239.0     0.83      53     10.0    227.3     0.81     110     10.0    193.4     0.81     260       
 65    12.6   275.4       9.6    243.9     0.76      49      9.6    230.8     0.76     104      9.3    194.5     0.74     239       
 69    12.1   278.2       9.9    247.8     0.82      50      9.8    231.6     0.81     106      8.2    192.1     0.68     214       
 73    12.5   284.1      10.5    248.4     0.84      53      9.7    233.2     0.78     104     10.0    195.1     0.80     256       
 77    12.8   290.5      10.4    254.4     0.81      51     10.1    237.2     0.79     107      9.9    197.0     0.77     250       
 81    12.8   296.4       9.9    255.5     0.77      49      9.9    236.8     0.77     105     10.1    200.4     0.79     252       
 85    12.2   297.1      10.3    257.5     0.84      50     10.4    241.0     0.85     108      9.7    197.3     0.80     245       
 89    12.3   301.2      10.3    257.9     0.84      50     10.1    243.6     0.82     104      9.7    200.3     0.79     242       
 93    12.3   305.2       9.8    259.2     0.80      47     10.0    247.2     0.81     101      9.5    202.4     0.77     235       
 97    12.9   299.5      11.0    264.8     0.85      52     10.7    250.1     0.83     107     10.2    202.7     0.79     252       
==================================================================================================================================  
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                       
                                             CHRONIC DOSED FEED STUDY OF 4-METHYLIMIDAZOLE                                          
==================================================================================================================================  
           0 PPM                      1250 PPM                           2500 PPM                           5000 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
101    13.0   311.3      10.6    263.5     0.82      51     11.2    253.3     0.86     110     10.4    202.1     0.80     257       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   11.6   161.4      10.8    157.8     0.93      89     10.3    156.9     0.89     171      8.9    130.3     0.77     346       
SD(D)   0.6               0.9              0.04      24      1.0              0.07      40      1.1              0.11      69       
CV(E)   5.6               8.6              4.5     26.6      9.7              8.0     23.2     12.9             13.8     19.9       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   11.3   220.8      10.1    211.0     0.90      60      9.5    207.2     0.85     115      8.7    169.7     0.77     257       
SD(D)   0.8               0.3              0.07       4      0.3              0.07       7      0.3              0.07      11       
CV(E)   6.7               3.3              8.0      7.1      3.1              8.0      6.4      3.1              9.6      4.5       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   12.4   285.7      10.1    250.6     0.81      50     10.0    236.9     0.81     106      9.6    196.3     0.77     245       
SD(D)   0.4               0.5              0.03       2      0.5              0.03       3      0.6              0.04      13       
CV(E)   3.5               5.0              3.5      3.5      5.3              3.8      2.8      6.5              4.7      5.1       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                DIAGNOSTIC TRAILER REPORT                                                                           
                                FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                                   
                                CHRONIC DOSED FEED STUDY OF 4-METHYLIMIDAZOLE                                                       
=========================================================================================================                           
           0 PPM                   625 PPM                  1250 PPM                 2500 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B              124.2  50                123.6  50                123.0  50                124.2  50                               
  1  17.5  6855  124.2  50    16.3  6867  123.6  50    14.5  6907  123.0  50    11.7  6942  124.2  50                               
  2  17.2  8139  179.2  50    17.1  8490  173.4  50    16.3  8467  165.1  50    15.6  8438  150.5  50                               
  3  19.2  8383  209.8  50    18.6  8267  204.5  50    17.3  8283  193.4  50    15.8  8450  180.1  50                               
  4  19.4  8438  240.4  50    18.5  8537  234.8  50    17.3  8517  221.4  50    16.2  8407  205.0  50                               
  5  19.4  7912  255.0  50    19.4  8278  250.2  50    18.3  8283  237.3  50    16.6  8438  222.7  50                               
  6  18.5  8383  269.7  50    18.0  8388  266.0  50    17.3  7889  252.3  50    16.1  8400  238.7  50                               
  7  18.8  8267  285.9  50    17.6  8422  279.8  50    16.9  8435  264.5  50    15.8  8250  250.4  50                               
  8  17.8  8200  304.2  50    17.3  7878  297.2  50    16.4  7859  280.1  50    15.2  8559  262.1  50                               
  9  17.6  8449  313.3  50    16.9  8468  306.8  50    15.6  8530  288.2  50    15.0  8330  270.2  50                               
 10  17.9  8216  324.3  50    17.3  8318  317.2  50    15.7  8280  295.1  50    14.9  8318  277.8  50                               
 11  17.8  8356  329.6  50    16.4  8532  321.0  50    15.2  8551  296.7  50    14.4  8433  279.9  50                               
 12  17.7  8445  341.7  50    16.2  8550  330.6  50    15.0  8542  303.8  50    14.4  8345  284.8  50                               
 13  17.4  8261  345.3  50    16.6  8147  331.7  50    15.0  8111  303.2  50    14.2  8082  283.6  50                               
 17  17.8  8404  365.2  50    16.9  8365  352.4  50    15.6  8349  322.2  50    14.1  8183  291.8  50                               
 21  18.9  7588  382.3  50    17.2  8151  367.5  50    16.9  8118  340.3  50    16.1  8068  312.9  50                               
 25  18.0  8492  395.3  50    16.4  8139  382.5  50    15.7  8438  350.9  50    14.6  8409  323.1  50                               
 29  18.4  7816  410.4  50    17.7  8306  395.7  50    16.3  8145  363.2  50    15.7  8087  335.9  50                               
 33  17.5  7786  417.5  50    17.2  7786  402.3  50    15.6  8283  369.8  50    14.7  8267  339.9  50                               
 37  17.7  8289  425.9  50    16.7  8155  408.0  50    15.9  8159  379.4  50    15.8  8160  342.7  50                               
 41  17.0  8389  428.8  50    16.9  7990  414.6  48    16.9  8256  379.7  50    15.3  8250  349.0  50                               
 45  17.1  8311  432.7  50    16.7  7814  419.0  48    15.4  8289  383.8  50    14.8  8146  352.9  50                               
 49  17.1  8383  437.3  50    16.9  8037  421.4  48    15.5  8366  385.0  50    15.4  8276  356.8  50                               
 53  16.5  8664  439.5  50    16.2  8274  428.9  48    15.1  8616  385.7  50    14.4  8515  358.5  50                               
 57  17.1  8270  437.9  50    16.6  6933  424.5  48    15.5  8209  390.1  50    15.3  7880  358.9  48                               
 61  17.9  8500  444.7  50    16.9  8069  428.1  48    15.8  8382  395.7  50    15.2  7987  364.0  48                               
 65  16.6  8417  448.0  50    16.1  8069  435.0  48    15.9  8333  395.6  50    15.3  8032  366.4  48                               
 69  16.5  8326  445.3  49    15.3  8000  430.2  47    15.1  8474  401.9  50    16.3  8084  367.1  48                               
 73  16.6  8094  443.5  49    16.0  7744  423.9  47    15.3  7908  395.4  48    14.4  7910  366.3  48                               
 77  15.8  8195  438.3  49    16.1  7634  424.6  46    14.8  7752  395.6  47    15.9  7918  365.0  48                               
 81  15.5  7929  437.8  48    14.9  7407  419.1  45    14.4  7519  386.4  46    14.7  7786  363.9  48                               
 85  15.6  7847  432.8  46    15.2  7278  416.1  42    14.6  7695  388.4  46    14.4  7849  362.3  47                               
 89  14.9  7539  421.2  45    14.1  6974  408.3  41    14.2  7270  386.5  44    13.9  7545  354.1  46                               
 93  15.9  7417  425.8  44    16.9  6730  414.4  40    13.9  6781  383.0  41    12.3  6905  348.9  42                               
 97  16.4  6679  422.1  41    15.8  6440  408.2  39    15.3  5958  381.2  39    14.7  5513  349.7  35                               
101  15.3  4825  400.2  36    14.1  5667  405.2  35    14.4  5808  378.1  36    15.0  5173  349.6  32                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          271.0                    264.4                    248.0                    233.1                                   
14 TO 52         410.6                    395.9                    363.8                    333.9                                   
 > 52            433.6                    420.5                    389.5                    359.6                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                DIAGNOSTIC TRAILER REPORT                                                                           
                                FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                                 
                                CHRONIC DOSED FEED STUDY OF 4-METHYLIMIDAZOLE                                                       
=========================================================================================================                           
           0 PPM                   1250 PPM                 2500 PPM                 5000 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B              100.1  50                 97.9  50                 99.5  50                 99.0  50                               
  1  12.7  6854  100.1  50    11.1  6934   97.9  50     8.8  6945   99.5  50     5.5  6964   99.0  50                               
  2  12.1  8654  127.4  50    12.1  8434  124.2  50    11.7  8473  118.3  50     9.6  8486   96.0  50                               
  3  12.4  8261  138.4  49    12.4  8279  137.0  50    11.4  8417  132.8  50    10.1  8199  109.3  50                               
  4  12.2  8261  148.7  49    11.5  8531  148.1  50    11.3  8394  143.5  50     9.0  8620  117.9  50                               
  5  11.9  7409  155.5  49    11.6  8284  154.9  50    11.0  7604  152.3  50     9.4  8410  125.8  50                               
  6  11.6  8226  163.1  49    11.2  6703  161.9  50    10.9  6729  161.1  50     9.4  8165  132.4  50                               
  7  11.8  7275  168.7  49    10.7  8420  166.0  50    11.3  8260  166.3  50     9.6  8535  136.8  50                               
  8  11.3  8365  176.0  49    10.4  8384  172.4  50    10.3  8540  171.8  50     9.3  8270  141.6  50                               
  9  11.0  8271  177.2  49    10.2  8528  173.4  50    10.2  8300  174.6  50     8.7  8616  143.3  50                               
 10  11.1  8051  181.6  49     9.8  8278  175.6  50     9.9  8355  178.2  50     8.6  8177  145.2  50                               
 11  10.9  8184  185.8  49     9.8  8551  178.3  50     9.6  8429  179.9  50     8.3  8714  146.1  50                               
 12  10.7  8282  186.5  49     9.6  8536  179.6  50     9.1  8340  180.5  50     8.3  8405  148.5  50                               
 13  10.8  8105  189.7  49     9.9  8115  182.1  50     9.0  8079  181.0  50     9.4  8069  151.7  50                               
 17  11.0  8237  194.4  49    10.1  8280  188.9  50     9.5  8016  188.9  49     8.7  8130  153.8  50                               
 21  11.8  4838  203.9  49    10.2  8114  194.4  50     9.9  7943  193.3  49     8.3  8073  157.7  50                               
 25  11.2  8325  211.8  49     9.7  8435  202.4  50     9.5  8247  201.6  49     8.3  8405  163.9  50                               
 29  11.4  8162  217.3  49    10.4  8146  208.8  50     9.3  7954  202.8  49     8.7  8060  166.7  50                               
 33  11.8  8144  223.1  49    10.8  8290  214.9  50     9.0  8114  209.0  49     8.6  8280  171.8  50                               
 37  12.3  8105  228.5  49     9.8  8160  218.3  50    10.0  7943  214.5  49     8.7  8095  173.9  50                               
 41   9.6  8223  227.7  49    10.2  8279  220.3  50     9.7  8071  216.3  49     9.1  8104  177.5  50                               
 45  11.1  7973  238.4  48     9.8  8290  223.4  50     9.3  8002  217.4  49     8.8  8140  178.9  50                               
 49  11.7  7357  242.4  48    10.2  8394  227.3  50     9.7  8119  221.4  49     9.1  8105  183.3  49                               
 53  11.3  8328  250.6  48     9.1  8611  231.9  50     9.1  8428  223.5  49     8.6  8267  186.6  48                               
 57  12.5  7930  254.7  48     9.8  8160  234.1  50     9.7  7888  224.1  48     9.3  7710  187.4  48                               
 61  12.3  8135  270.1  48    10.2  8235  239.0  49    10.0  7963  227.3  48    10.0  7755  193.4  48                               
 65  12.6  8150  275.4  48     9.6  8054  243.9  48     9.6  8052  230.8  48     9.3  7948  194.5  48                               
 69  12.1  8188  278.2  48     9.9  7991  247.8  47     9.8  8088  231.6  48     8.2  7900  192.1  48                               
 73  12.5  7758  284.1  47    10.5  7732  248.4  47     9.7  7885  233.2  48    10.0  7719  195.1  48                               
 77  12.8  7855  290.5  47    10.4  7711  254.4  46    10.1  7932  237.2  48     9.9  7745  197.0  48                               
 81  12.8  7765  296.4  47     9.9  7554  255.5  46     9.9  7447  236.8  46    10.1  7115  200.4  45                               
 85  12.2  8027  297.1  47    10.3  7766  257.5  46    10.4  7332  241.0  44     9.7  7346  197.3  45                               
 89  12.3  7854  301.2  47    10.3  7621  257.9  46    10.1  7171  243.6  43     9.7  7264  200.3  45                               
 93  12.3  7776  305.2  46     9.8  7470  259.2  45    10.0  6612  247.2  40     9.5  6884  202.4  42                               
 97  12.9  6500  299.5  45    11.0  7066  264.8  42    10.7  6354  250.1  38    10.2  6590  202.7  40                               
101  13.0  6991  311.3  43    10.6  6599  263.5  40    11.2  5656  253.3  35    10.4  6101  202.1  37                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          161.4                    157.8                    156.9                    130.3                                   
14 TO 52         220.8                    211.0                    207.2                    169.7                                   
 > 52            285.7                    250.6                    236.9                    196.3                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.