National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/18924

TDMS Study 93020-05 Pathology Tables

 NTP Experiment-Test: 93020-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97
Route: SKIN APPLICATION                                                                                           Time: 14:04:40

                                                       150 DAY SUBCHRONIC




       Facility:  Microbiological Associates

       Chemical CAS #:  693-13-0

       Lock Date:  03/26/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 93020-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:04:40  
____________________________________________________________________________________________________________________________________

         TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0            4.38         8.75         17.5         35           70              
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                      1                                      1            2                        
    Moribund Sacrifice                                 1            2            2            1            2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8            8            8            8            6           10           

  Animals Examined Microscopically                    10            8           10            9            9           10           
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 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (9)          (2)          (2)          (1)          (2)          (10)         
      Ulcer, Chronic Active                            1 (11%)                                                                      
   Liver                                              (10)         (6)          (7)          (7)          (6)          (10)         
      Hematopoietic Cell Proliferation                 1 (10%)                   1 (14%)                                1 (10%)     
      Inflammation                                                               1 (14%)                                            
      Inflammation, Focal                              7 (70%)      4 (67%)      3 (43%)      7 (100%)     2 (33%)      8 (80%)     
      Necrosis                                         1 (10%)                   1 (14%)                                            
   Pancreas                                           (9)          (2)          (2)          (1)          (4)          (10)         
      Inflammation, Focal                              1 (11%)                                                                      
   Stomach, Glandular                                 (10)         (2)          (2)          (2)          (2)          (10)         
      Inflammation                                                                                                      1 (10%)     
   Tongue                                                                                                 (1)                       
      Epithelium, Hyperkeratosis                                                                           1 (100%)                 
   Tooth                                              (3)          (4)          (4)          (6)          (3)          (7)          
      Hyperplasia, Odontogenic                                                                             1 (33%)      1 (14%)     
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 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (10)         (2)          (2)          (2)          (4)          (10)         
      Aorta, Adventitia, Inflammation, Focal           1 (10%)                                                                      
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 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
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a  Number of animals examined microscopically at site and number of animals with lesion                                             

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NTP Experiment-Test: 93020-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:04:40  
____________________________________________________________________________________________________________________________________

         TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0            4.38         8.75         17.5         35           70              
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (7)          (2)          (1)          (1)          (2)          (8)          
      Atrophy                                                       1 (50%)                   1 (100%)                              
   Uterus                                             (10)         (2)          (2)          (2)          (4)          (10)         
      Hydrometra                                       1 (10%)                                                          2 (20%)     
      Bilateral, Hydrometra                            2 (20%)                                             1 (25%)      1 (10%)     
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 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (2)          (2)          (2)          (4)          (10)         
      Myeloid Cell, Hyperplasia                        1 (10%)                   1 (50%)                                            
   Lymph Node                                                                   (1)          (1)                                    
      Infiltration Cellular, Plasma Cell                                         1 (100%)                                           
      Infiltration Cellular, Histiocyte                                          1 (100%)                                           
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                                          1 (100%)                              
   Lymph Node, Mandibular                             (10)         (2)          (2)          (1)          (4)          (10)         
      Infiltration Cellular, Plasma Cell               1 (10%)                   1 (50%)      1 (100%)                              
      Infiltration Cellular, Polymorphonuclear         1 (10%)                                                          1 (10%)     
   Lymph Node, Mesenteric                             (9)          (2)          (2)          (1)          (4)          (10)         
      Infiltration Cellular, Polymorphonuclear         1 (11%)                                                                      
      Infiltration Cellular, Histiocyte                1 (11%)                   1 (50%)                                            
      Inflammation                                                                                                      1 (10%)     
      Inflammation, Focal                                                        1 (50%)                   1 (25%)                  
      Pigmentation                                                  1 (50%)                                                         
   Spleen                                             (9)          (5)          (3)          (3)          (6)          (10)         
      Fibrosis                                                                                1 (33%)                               
      Hematopoietic Cell Proliferation                 7 (78%)      5 (100%)     2 (67%)      1 (33%)      5 (83%)      9 (90%)     
      Lymphoid Follicle, Necrosis                                                                          1 (17%)                  
   Thymus                                             (9)          (2)          (2)                       (3)          (10)         
      Atrophy                                          1 (11%)      2 (100%)     1 (50%)                                            
      Thymocyte, Necrosis                              1 (11%)                   1 (50%)                   1 (33%)                  
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 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (3)          (4)          (4)          (4)          (10)         
      Dermis, Atrophy                                                            1 (25%)                                            
      Dermis, Skin, Site of Application,                                                                                            
          Inflammation                                                           1 (25%)                   1 (25%)      1 (10%)     
      Epidermis, Hyperplasia                                                     1 (25%)                                            
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                                            1 (25%)                   1 (25%)                  
      Epidermis, Skin, Site of Application,                                                                                         
          Inflammation                                                           2 (50%)                                            
      Epidermis, Skin, Site of Application,                                                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 93020-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:04:40  
____________________________________________________________________________________________________________________________________

         TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0            4.38         8.75         17.5         35           70              
                                                   MG/KG        MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
          Inflammation, Chronic Active                                                                                  1 (10%)     
      Skin, Site of Application, Ulcer, Chronic                                                                                     
          Active                                                                 1 (25%)                                            
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (2)          (2)          (3)          (4)          (10)         
      Inflammation, Chronic, Focal                     1 (10%)                                                                      
      Inflammation, Chronic Active, Focal                                                     1 (33%)                   1 (10%)     
      Inflammation, Focal                              2 (20%)                   1 (50%)                                            
   Nose                                               (10)         (5)          (1)          (2)          (4)          (10)         
      Inflammation                                     2 (20%)      3 (60%)                                             2 (20%)     
                                                                                                                                    
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

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