TDMS Study 93020-05 Pathology Tables
NTP Experiment-Test: 93020-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:04:40
150 DAY SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 693-13-0
Lock Date: 03/26/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 93020-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:04:40
____________________________________________________________________________________________________________________________________
TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 4.38 8.75 17.5 35 70
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 1 1 2
Moribund Sacrifice 1 2 2 1 2
Survivors
Terminal Sacrifice 8 8 8 8 6 10
Animals Examined Microscopically 10 8 10 9 9 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (9) (2) (2) (1) (2) (10)
Ulcer, Chronic Active 1 (11%)
Liver (10) (6) (7) (7) (6) (10)
Hematopoietic Cell Proliferation 1 (10%) 1 (14%) 1 (10%)
Inflammation 1 (14%)
Inflammation, Focal 7 (70%) 4 (67%) 3 (43%) 7 (100%) 2 (33%) 8 (80%)
Necrosis 1 (10%) 1 (14%)
Pancreas (9) (2) (2) (1) (4) (10)
Inflammation, Focal 1 (11%)
Stomach, Glandular (10) (2) (2) (2) (2) (10)
Inflammation 1 (10%)
Tongue (1)
Epithelium, Hyperkeratosis 1 (100%)
Tooth (3) (4) (4) (6) (3) (7)
Hyperplasia, Odontogenic 1 (33%) 1 (14%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (10) (2) (2) (2) (4) (10)
Aorta, Adventitia, Inflammation, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 93020-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:04:40
____________________________________________________________________________________________________________________________________
TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 4.38 8.75 17.5 35 70
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (7) (2) (1) (1) (2) (8)
Atrophy 1 (50%) 1 (100%)
Uterus (10) (2) (2) (2) (4) (10)
Hydrometra 1 (10%) 2 (20%)
Bilateral, Hydrometra 2 (20%) 1 (25%) 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (2) (2) (2) (4) (10)
Myeloid Cell, Hyperplasia 1 (10%) 1 (50%)
Lymph Node (1) (1)
Infiltration Cellular, Plasma Cell 1 (100%)
Infiltration Cellular, Histiocyte 1 (100%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (100%)
Lymph Node, Mandibular (10) (2) (2) (1) (4) (10)
Infiltration Cellular, Plasma Cell 1 (10%) 1 (50%) 1 (100%)
Infiltration Cellular, Polymorphonuclear 1 (10%) 1 (10%)
Lymph Node, Mesenteric (9) (2) (2) (1) (4) (10)
Infiltration Cellular, Polymorphonuclear 1 (11%)
Infiltration Cellular, Histiocyte 1 (11%) 1 (50%)
Inflammation 1 (10%)
Inflammation, Focal 1 (50%) 1 (25%)
Pigmentation 1 (50%)
Spleen (9) (5) (3) (3) (6) (10)
Fibrosis 1 (33%)
Hematopoietic Cell Proliferation 7 (78%) 5 (100%) 2 (67%) 1 (33%) 5 (83%) 9 (90%)
Lymphoid Follicle, Necrosis 1 (17%)
Thymus (9) (2) (2) (3) (10)
Atrophy 1 (11%) 2 (100%) 1 (50%)
Thymocyte, Necrosis 1 (11%) 1 (50%) 1 (33%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (3) (4) (4) (4) (10)
Dermis, Atrophy 1 (25%)
Dermis, Skin, Site of Application,
Inflammation 1 (25%) 1 (25%) 1 (10%)
Epidermis, Hyperplasia 1 (25%)
Epidermis, Skin, Site of Application,
Hyperplasia 1 (25%) 1 (25%)
Epidermis, Skin, Site of Application,
Inflammation 2 (50%)
Epidermis, Skin, Site of Application,
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 93020-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:04:40
____________________________________________________________________________________________________________________________________
TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 4.38 8.75 17.5 35 70
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Chronic Active 1 (10%)
Skin, Site of Application, Ulcer, Chronic
Active 1 (25%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (2) (2) (3) (4) (10)
Inflammation, Chronic, Focal 1 (10%)
Inflammation, Chronic Active, Focal 1 (33%) 1 (10%)
Inflammation, Focal 2 (20%) 1 (50%)
Nose (10) (5) (1) (2) (4) (10)
Inflammation 2 (20%) 3 (60%) 2 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------