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TDMS Study 92013-05 Pathology Tables

NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04
Route: DOSED FEED                                                                                                 Time: 08:41:26

                                                         FINAL #1 RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  822-36-6

       Lock Date:  09/13/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 4| 4| 4| 7| 7| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +|             
      Edema                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  A  M|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X     X  X  X|             
      Clear Cell Focus                     |    X  X  X  X              X                 X  X  X                     |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic, Focal          |                            1                                             |             
      Eosinophilic Focus                   |          X                                                               |             
      Hematopoietic Cell Proliferation     |                                                                         3|             
      Hepatodiaphragmatic Nodule           |       X        X                       X                                 |             
      Histiocytosis                        | 1  1  1  1  1  1  1  1  1  1        1  1  1     1  1     1        1  1  1|             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic                |    1  2  1                 1     1           1                           |             
      Inflammation, Granulomatous          |             1                                                            |             
      Mixed Cell Focus                     |             X                 X                                          |             
      Bile Duct, Hyperplasia               | 1  2     2  1  1              1  2  1  1  2  2  1           2        1  1|             
      Hepatocyte, Fatty Change, Focal      | 1  1                    1                          1        2     1      |             
      Hepatocyte, Hyperplasia, Focal       |                                                       3                  |             
      Hepatocyte, Necrosis, Focal          |                                                                      2   |             
      Hepatocyte, Vacuolization Cytoplasmic|                                           2           3        4        2|             
      Hepatocyte, Centrilobular, Necrosis  |                                                       3                  |             
      Oval Cell, Hyperplasia, Focal        |                                           2                              |             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +              +              +           +        +            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 4| 4| 4| 7| 7| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Inflammation, Chronic                |                                                             3            |             
      Fat, Necrosis, Focal                 |          3              2              2           2        3            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Acinus, Atrophy, Diffuse             |                   4                                                      |             
      Acinus, Atrophy, Focal               |    1  1              2  1                       2                 1  2   |             
      Duct, Cyst, Focal, Multiple          |          2  1  2                          1           2        1         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                3         |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                       2              2   |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                      +   |             
      Peridontal Tissue, Inflammation      |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                         +                                                |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  1              1              1  1  1  1  1  1  1        1  2     2|             
      Epicardium, Inflammation             |                                                       3                  |             
      Myocardium, Fibrosis, Focal          |                                                                          |             
      Pericardium, Infiltration Cellular,  |                                                                          |             
           Mixed Cell                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                2           1                       1                     |             
      Angiectasis                          | 3  3                                                                     |             
      Cytoplasmic Alteration, Focal        |                                              2                           |             
      Vacuolization Cytoplasmic, Focal     |                      2              3                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 4| 4| 4| 7| 7| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Focal                   |                               1                 1                        |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   3      |             
      Pars Distalis, Angiectasis           |             3                                                            |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           | 1                          3        2     1     2                        |             
      Pars Distalis, Hyperplasia, Focal    |             2                                                     3      |             
      Pars Distalis, Hypertrophy, Focal    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +|             
      C-Cell, Hyperplasia                  | 2  2  4  2  2  2  2  3  2  2  4  2  2  2  1  2  2  3           1  2     3|             
      Follicle, Mineralization             |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                       +              +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Mediastinum, Cyst                    |                                                                         2|             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Mixed Cell                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                2        2                                            3   |             
      Hyperplasia, Cystic                  |    3                          2                                2         |             
      Inflammation, Chronic                |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 4| 4| 4| 7| 7| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Cyst                                 |             X     X  X  X                                         X      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Granulomatous |                                                             3            |             
      Cervix, Hypertrophy                  |                                                             3            |             
      Endometrium, Hyperplasia, Cystic     | 1        1  1                       2  1  3                    2     2  1|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +           +  +     +  +  +           +  +  A  +  +  +  +|             
      Deep Cervical, Hemorrhage            |                                                                         3|             
      Mediastinal, Ectasia                 |          4                    3           3                              |             
      Mediastinal, Hemorrhage              |       3                                               3                  |             
      Mediastinal, Hyperplasia, Histiocytic|             3                 3                                   3      |             
      Mediastinal, Hyperplasia, Lymphoid   |                                        3                                 |             
      Mediastinal, Pigmentation            |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia, Histiocytic |                3           3                                      3      |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                                      3   |             
      Pancreatic, Pigmentation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  M  M  M  M  M  M  M  M  M  M  M  M     M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Histiocytic             |                3  3  3     3  3                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                            X                                      X      |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                       3              3  3|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  I  +  +  +  I|             
      Cyst                                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 4| 4| 4| 7| 7| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia, Lymphoid                |       4                                                                  |             
      Epithelial Cell, Hyperplasia         |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 4        2  3     4  4  2  3  2  3  4  4  2  2  2  2  2  3  3  2  2  3  2|             
      Fibrosis                             |       3                                                                  |             
      Hyperplasia                          |    2                       3                                3            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                   3     3     1  3                          3            |             
      Hemorrhage, Focal                    |                                                                2         |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                +  +  +     +  +                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                +  +  +     +  +                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Infiltration Cellular, Mixed Cell    |             1                                                        2  2|             
      Inflammation, Chronic, Focal         | 1  1     1  1     1  1           1  1        1  1           2  1         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |       2        2           2           2                                 |             
      Interstitium, Edema                  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 4| 4| 4| 7| 7| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Mediastinum, Edema                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |          2                                                               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
      Cataract                             |                                              2                           |             
      Synechia                             |                                              3                           |             
      Retina, Degeneration                 |                                              3                           |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|             
      Infarct                              |                                                                          |             
      Nephropathy                          | 2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1        1  1     1|             
      Pelvis, Dilatation                   |                3                                                         |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                         2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Edema                                |                                                                   3      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X     X  X|     46     |
      Clear Cell Focus                     | X  X  X     X     X     X  X                       X        X  X     X  X|     20     |
      Congestion                           |                3                                         3               |      2  3.0|
      Degeneration, Cystic, Focal          |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |    X                 X                                                   |      5     |
      Histiocytosis                        | 1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1        1     1  1|     40  1.0|
      Infiltration Cellular, Mixed Cell    |       1              1              1           1           1            |      5  1.0|
      Inflammation, Chronic                |                      2  2     1     1  1     1  1     1        1     1  1|     17  1.2|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Mixed Cell Focus                     |    X                          X     X  X              X     X        X  X|     10     |
      Bile Duct, Hyperplasia               | 2     2        2  1     1  2  2     2  1     2  1     1     2  1  2     1|     31  1.5|
      Hepatocyte, Fatty Change, Focal      | 1  1           1        1     1        1  2           1     2           1|     16  1.2|
      Hepatocyte, Hyperplasia, Focal       |                                                                          |      1  3.0|
      Hepatocyte, Necrosis, Focal          |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                  2                       3               |      6  2.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Centrilobular, Necrosis  |                                                          3               |      2  3.0|
      Oval Cell, Hyperplasia, Focal        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                      +                                +     +     +      |   9        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                      3                                3     2            |      8  2.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Diffuse             |                                                                          |      1  4.0|
      Acinus, Atrophy, Focal               |                1     1  1           2                          1     1   |     13  1.3|
      Duct, Cyst, Focal, Multiple          |       2  1     1  2                                                      |     10  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Ulcer                                |                                                                   1      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  1     1  1  1  2        1  1           2        1  1  2  2  1     1  1|     30  1.3|
      Epicardium, Inflammation             |                                                                          |      1  3.0|
      Myocardium, Fibrosis, Focal          |                                                          2               |      1  2.0|
      Pericardium, Infiltration Cellular,  |                                                                          |            |
           Mixed Cell                      |                                                          1               |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    | 1                    1        1                                      1  2|      8  1.3|
      Angiectasis                          |                                                          2              2|      4  2.5|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |    1                    2              2        2              4  2      |      8  2.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                          2               |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  48        |
      Angiectasis                          |             3     3                 2                       3     3      |      6  2.8|
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           | 3                       2           2                                1   |      9  1.9|
      Pars Distalis, Hyperplasia, Focal    |                         1           1                                    |      4  1.8|
      Pars Distalis, Hypertrophy, Focal    |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      C-Cell, Hyperplasia                  | 1  2  2  1  1     2  1  2  2  1  1  2  2  2  1  4  1  3  1  2  2  2  1  2|     45  2.0|
      Follicle, Mineralization             |                                              1     1                     |      2  1.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                          +           +   |   5        |
      Fibrosis, Focal                      |                                                                      2   |      1  2.0|
      Mediastinum, Cyst                    |                                                                          |      1  2.0|
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
           Mixed Cell                      |                                                          1               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                         2                                                |      4  2.3|
      Hyperplasia, Cystic                  |             3        2                          2                    3   |      7  2.4|
      Inflammation, Chronic                |                         2                                                |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         X  X                                             |      7     |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Granulomatous |                                                                          |      1  3.0|
      Cervix, Hypertrophy                  |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |    2  2  2     1  2  2     1  1     1           1  2  1     1  2     2  1|     25  1.5|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                           3                              |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +                                            +  +  +  +  +  +  +     +|  24        |
      Deep Cervical, Hemorrhage            |                                                             3  3         |      3  3.0|
      Mediastinal, Ectasia                 |                                                                          |      3  3.3|
      Mediastinal, Hemorrhage              |    3                                                  3  3               |      5  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                                         3|      4  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                                          3               |      1  3.0|
      Pancreatic, Hemorrhage               |                                                          2               |      1  2.0|
      Pancreatic, Hyperplasia, Histiocytic |                                                 3  3        2            |      6  2.8|
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Pancreatic, Pigmentation             |                                                          2               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Histiocytic             |                                                 3                 3      |      7  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                       X                  |      3     |
      Fibrosis, Focal                      |                                           3                              |      1  3.0|
      Hematopoietic Cell Proliferation     |                                  3        3                       3      |      6  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                           3        2                     |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |          3  2  3     3     2  2     2  3        3  4  2     4  3     2  2|     37  2.7|
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperplasia                          |       2              3                 2                                 |      6  2.5|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                    2                     |      1  2.0|
      Subcutaneous Tissue, Edema           |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |       3        3              3        3  2     4     3                 3|     13  2.8|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                          +        +      |   7        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                          +        +      |   7        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                2                                                         |      1  2.0|
      Hemorrhage, Focal                    |                                                                   3      |      1  3.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      3  1.7|
      Inflammation, Chronic, Focal         |    1  1     1  2  1  1     1                    1  1  1     1  1        1|     25  1.1|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      4  2.0|
      Interstitium, Edema                  |                                                          2               |      1  2.0|
      Mediastinum, Edema                   |                                                          2               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Nasolacrimal Duct, Inflammation      | 3                                                                        |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cataract                             |                      3     3                    3                        |      4  2.8|
      Synechia                             |                                                                          |      1  3.0|
      Retina, Degeneration                 |                      3     3                    3                        |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3|            |
                                           | 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Inflammation                         |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infarct                              |                                     2                                    |      1  2.0|
      Nephropathy                          | 1  1  1  1  1  1  1  1  1  1  2     2  1  1  1  1  1  1     1  1  1  1  1|     45  1.1|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                   4     2|      3  2.7|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 2| 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 2| 1| 3| 3| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X|             
      Clear Cell Focus                     | X  X  X              X  X  X  X  X  X  X        X           X  X  X  X  X|             
      Congestion                           |                                                                2         |             
      Eosinophilic Focus                   |                                           X                              |             
      Hepatodiaphragmatic Nodule           |                                           X                              |             
      Histiocytosis                        | 1  1  1  1  1  1  1  1  1  1  1  1  2  2  1  1  1  1  1  2  1  1  2  2  1|             
      Infiltration Cellular, Mixed Cell    |       1                                         1           1            |             
      Inflammation, Chronic                | 1  1  1     2        1  1  1  1     2  2           1        3     1      |             
      Mixed Cell Focus                     |          X                                X                    X  X      |             
      Bile Duct, Hyperplasia               | 1  1  1  1  2        2  1  2  1  2  2  2     3  2  1  1  1     1  1  2  2|             
      Hepatocyte, Fatty Change, Focal      | 1     1  1              1  2              2     1     2        2  1  2  1|             
      Hepatocyte, Vacuolization Cytoplasmic|             3  1  2  2                       2     3     2               |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Acinus, Atrophy, Focal               | 2                          1        1  1     2                       2  2|             
      Duct, Cyst, Focal, Multiple          | 2  2                                1  2     2              2     2  3  2|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          4                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 2| 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 2| 1| 3| 3| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                      +                                                   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Malformation                         |                                                                          |             
      Peridontal Tissue, Inflammation      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  2  1     1     2  2  1        1  2  1     1  1  1  2  1  2  1  2  1|             
      Inflammation, Focal, Suppurative     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                           1           1        1         |             
      Angiectasis                          |                2                                                     3   |             
      Cytoplasmic Alteration, Focal        |                                        1                                 |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |          2  2                                               2  1         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 2| 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 2| 1| 3| 3| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               3     2        2                           |             
      Cyst                                 |                               X     X                                    |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                                     2  1                                 |             
      Pars Distalis, Hyperplasia, Focal    |                                                                         2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  2  2  1           1  1  1  2  2  1  1  2  3  2  2  2     1  3  3  1  2|             
      Follicle, Cyst                       |                                        X                                 |             
      Follicle, Mineralization             |                                                       1     1     1     1|             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                   +                                      +               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                            2  3                                          |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     | 2  3  1  2              1        1  2  2     1  3     3     3  2  1  2  1|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 2| 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 2| 1| 3| 3| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                        2                                 |             
      Hyperplasia                          |                                                                          |             
      Erythroid Cell, Hyperplasia          |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +  +                                            +      |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Ectasia                 |                                                                   3      |             
      Mediastinal, Hemorrhage              |                      3                                                   |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
      Ectasia                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                       3     2            |             
      Inflammation, Granulomatous          |                                                                          |             
      Stromal Hyperplasia                  |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Dilatation                           | 2                    3  4  2        2     3                       2      |             
      Hyperplasia                          |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Pinna, Inflammation, Chronic, Focal  |                                                                          |             
      Subcutaneous Tissue, Edema           |             2                                                            |             
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 2| 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 2| 1| 3| 3| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                      3  3                                                |             
      Hemorrhage, Focal                    |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                      +                                                   |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3              1           2                              |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                1                                                         |             
      Inflammation, Chronic, Focal         | 1  1  2  1  1  1     1  1  1  1  1  1  1     1  1  1  2     2     1  1  1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                    2        1            |             
      Mediastinum, Edema                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                              1                           |             
      Inflammation, Suppurative            |                                              1                           |             
      Nasolacrimal Duct, Inflammation      |                                  1                 2                     |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Anterior Chamber, Exudate            |                                  3                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 2| 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 6| 6| 6| 2| 1| 3| 3| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1250 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Cornea, Necrosis, Focal              |                                                                          |             
      Retina, Degeneration                 |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |          2                                                     1         |             
      Inflammation                         |                                        1                                 |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |    +                                      +                              |             
      Cyst                                 |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Mineralization, Focal                |                                                                          |             
      Nephropathy                          | 1  1  1  1              1  1  1  1  1  1  1  1     1  1     1  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3|            |
                                           | 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X  X     X  X  X     X  X  X  X  X  X  X  X     X  X     X  X  X  X  X|     43     |
      Clear Cell Focus                     |    X  X     X  X  X        X  X  X  X  X     X     X  X           X  X  X|     32     |
      Congestion                           |                      3                                                   |      2  2.5|
      Eosinophilic Focus                   |                                                       X                  |      2     |
      Hepatodiaphragmatic Nodule           |                      X     X                             X               |      4     |
      Histiocytosis                        | 1  2  2  1  1  2  2  1  2  1  1  2  2  2  1  1  1  1  1  2  2  1  1  1  1|     50  1.3|
      Infiltration Cellular, Mixed Cell    |       2        2                                                         |      5  1.4|
      Inflammation, Chronic                |    1  1     1  1  2     2  1  1  1  4        2     1     3     1  1      |     28  1.5|
      Mixed Cell Focus                     |       X                                X           X                     |      7     |
      Bile Duct, Hyperplasia               | 2  2  1  2           3  2        1  1  2  1  2  2  2  2        1  2     2|     38  1.6|
      Hepatocyte, Fatty Change, Focal      |    1     2  1  1     2     1  2  2     3     3  2  2  2     1  1     1  2|     29  1.6|
      Hepatocyte, Vacuolization Cytoplasmic| 3        3                                      2        2  2            |     12  2.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +                    +        +     +  +  +                              |   7        |
      Fat, Necrosis, Focal                 |                               2     1  3                                 |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               |    3           2  1     1  3     2  2  2        1  1  2  2     1  2     1|     22  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3|            |
                                           | 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Duct, Cyst, Focal, Multiple          |       2  2                    3  2  1        2     1                 2  3|     18  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |          3                                                               |      1  3.0|
      Ulcer                                |                                                             2            |      1  2.0|
      Epithelium, Hyperplasia              |                                                 2                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              | 2                                                                        |      1  2.0|
      Ulcer                                |                                                 2                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                        +  +  +                    +      |   5        |
      Epithelium, Hyperplasia              |                                        2                                 |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |          +                                                               |   1        |
      Malformation                         |          2                                                               |      1  2.0|
      Peridontal Tissue, Inflammation      |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                   +      |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1  1     1  2  1  3  1  2  2  2  2  2  2  2  2  1  2  1  1  1  1  2  1|     43  1.5|
      Inflammation, Focal, Suppurative     |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                       1     2  1         |      6  1.2|
      Angiectasis                          |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3|            |
                                           | 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Cytoplasmic Alteration, Focal        |                               1                                          |      2  1.0|
      Hematopoietic Cell Proliferation     |          1                                                               |      1  1.0|
      Vacuolization Cytoplasmic, Focal     |    2  1  2           3                 3                                 |      9  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                   3      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                2         |      4  2.3|
      Cyst                                 |       X                 X                                                |      4     |
      Hyperplasia, Focal, Histiocytic      |             2                                                            |      1  2.0|
      Pars Distalis, Angiectasis           |    1                                                                    1|      2  1.0|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |    2                       3              3                    4         |      6  2.5|
      Pars Distalis, Hyperplasia, Focal    |    2        3                                      2                     |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  I  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  44        |
      C-Cell, Hyperplasia                  | 1     1  2  1  1        2  2  1  1  1  2  2  1     2  2  2  2  1  2  4  2|     42  1.7|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicle, Mineralization             |       1                                1                       1         |      7  1.0|
      Follicular Cell, Hyperplasia, Focal  |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                           +                              |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |                2                                            2            |      4  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3|            |
                                           | 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation, Chronic                |    1                                                                    2|      2  1.5|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        X  X                              |      3     |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     | 1  2        1     1        2  3  2  2     2              3               |     26  1.9|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |          +           +                                                   |   2        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Fibrosis                             |                      3                                                   |      1  3.0|
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  2.0|
      Hyperplasia                          |          3              3                                                |      2  3.0|
      Erythroid Cell, Hyperplasia          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +              +     +  +                 +     +           +        +   |  11        |
      Mediastinal, Congestion              |                                                 3                        |      1  3.0|
      Mediastinal, Ectasia                 |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                3                                                     2   |      3  2.7|
      Mediastinal, Hyperplasia, Histiocytic|                                                             3            |      1  3.0|
      Pancreatic, Hyperplasia, Histiocytic |                         3                                                |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M|   3        |
      Ectasia                              |                         3                                                |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3|            |
                                           | 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Inflammation, Granulomatous          |                         3           2                    3               |      3  2.7|
      Stromal Hyperplasia                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |          3           2     2           3  2  2  2           2     1      |     16  2.3|
      Hyperplasia                          |          2                                                              1|      3  1.7|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                     3                                    |      1  3.0|
      Pinna, Inflammation, Chronic, Focal  |                      2                                                   |      1  2.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Fibrosis, Focal |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |          3                             3     3  3           3     3      |      8  3.0|
      Hemorrhage, Focal                    | 3                                                                        |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |       +     +                                                            |   3        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |       +     +                                                            |   3        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3|            |
                                           | 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |       3                                         2                        |      5  2.2|
      Hyperplasia, Focal, Histiocytic      |                                     2                                    |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  1.0|
      Inflammation, Chronic, Focal         |       2  1  1  1  1     2  2  1  1     1        1  1  1  1  1  1  1  1  2|     40  1.2|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                   1      |      3  1.3|
      Mediastinum, Edema                   |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                       2                  |      2  1.5|
      Inflammation, Suppurative            |                                                 3     2                  |      3  2.0|
      Nasolacrimal Duct, Inflammation      |                   3                                2              2      |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Chronic                |          4                                                               |      1  4.0|
      Anterior Chamber, Exudate            |                                                                          |      1  3.0|
      Cornea, Inflammation, Chronic        |                                        4                                 |      1  4.0|
      Cornea, Necrosis, Focal              |                                        4                                 |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |    1                                                           2         |      4  1.5|
      Inflammation                         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |          +                                                               |   3        |
      Cyst                                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3|            |
                                           | 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    1250 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Infarct                              |                      2                                                   |      1  2.0|
      Mineralization, Focal                |          2                                                               |      1  2.0|
      Nephropathy                          | 1  1  1     1        3  1  1  1  1  2  3  1  1     1  1        1  1  1   |     37  1.1|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  M  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X  X     X  X     X  X  X  X  X     X        X  X     X  X     X  X|             
      Clear Cell Focus                     | X     X  X     X  X     X  X  X  X  X              X           X        X|             
      Degeneration, Cystic, Focal          |                                                                3         |             
      Eosinophilic Focus                   |                                                             X  X     X   |             
      Hepatodiaphragmatic Nodule           |                                                 X                       X|             
      Histiocytosis                        | 2  2  2  2  2  2  2     2  1  2  2  1  2  2  1  3  1  2  3  2  1  1  2  1|             
      Inflammation, Chronic, Focal         |    1                                                                     |             
      Inflammation, Chronic                | 3        1     2  1     2  2  1  2  2     1        1  1  2  2  1     1  1|             
      Mixed Cell Focus                     |                                                       X  X  X  X     X   |             
      Thrombosis                           |    2                                                                     |             
      Bile Duct, Dilatation, Focal         |                                                                3         |             
      Bile Duct, Hyperplasia               | 2  2  3  1  2  2  1        1  2  2  1  3     2  3     2  2  1  3  3  1  1|             
      Hepatocyte, Fatty Change, Focal      |       2  1  2     3     3     2  2  1           2  2     2  1  3  2  2  3|             
      Hepatocyte, Vacuolization Cytoplasmic|    4  3     3              2        2  2     1        2        2         |             
      Hepatocyte, Centrilobular, Necrosis  |    3                                                                     |             
      Serosa, Fibrosis                     |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +  +                          +     +  +           +            |             
      Inflammation, Chronic                |          1                                                               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               | 2              3           2  1           2  1     2  1  1     1  3     1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Duct, Cyst, Focal, Multiple          |             1           1  2                       1                 2  1|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                2         |             
      Inflammation, Chronic                |             3                                                            |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Edema                                |                                              3                           |             
      Inflammation                         |    1                                         3                           |             
      Ulcer                                |                                              2                           |             
      Epithelium, Hyperplasia              |             2                                2                    2      |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                   +                          +                 +         |             
      Epithelium, Hyperplasia              |                                                                1         |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
      Malformation                         |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                      +                          +                        |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Cardiomyopathy                       |       2  2  2  2  2     2  1  3  1  2              2  2  2     2  1  1  1|             
      Thrombosis                           |    3                                                                     |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          2     1                                                         |             
      Angiectasis                          |       3                                                                  |             
      Cytoplasmic Alteration, Focal        |                         1                                                |             
      Hemorrhage, Focal                    |                                              3                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |       3  2  3     2           1              3                    1  3   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Focal                   |                                                             3            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Cyst                                 |                X                                                  X      |             
      Pars Distalis, Angiectasis           |                                  2                                       |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           | 2                                                                        |             
      Pars Distalis, Hemorrhage, Focal     |                                                    2                     |             
      Pars Distalis, Hyperplasia, Focal    |                               1  3                                3      |             
      Pars Distalis, Hypertrophy, Focal    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  A  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 4     2  2  2  2  1     3  2  1  1  2        1     2  1  3  2  2  2  1  2|             
      Follicle, Degeneration, Focal        |                                                                          |             
      Follicle, Mineralization             |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                        +        +           +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       3                                                  3               |             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               X                          X              X|             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                 +                        |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |          1        2  1  3  2     2  1              3                     |             
                                           |__________________________________________________________________________|             
   Vagina                                  |    +        +                                +                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                              3                           |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +        +              +     +  +           +        +   |             
      Mediastinal, Hemorrhage              |                3                                                     3   |             
      Mediastinal, Hyperplasia, Histiocytic|                         3                                                |             
      Mediastinal, Hyperplasia, Plasma Cell|                                              3                           |             
      Pancreatic, Hemorrhage               |                                                             3            |             
      Pancreatic, Hyperplasia, Histiocytic |    3  3                                      3              3            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                         3                                                |             
      Hyperplasia, Histiocytic             |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Atrophy                              |    3                                                                     |             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                                              3                           |             
      Inflammation, Granulomatous          |       3        3                                      3     4            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Capsule, Infiltration Cellular,      |                                                                          |             
          Focal, Mixed Cell                |                                                          2               |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                                   |             
      Hyperplasia, Lymphoid                |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    1        3                                         3                  |             
      Hyperplasia                          |                                                       2                 1|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                                          |             
      Epidermis, Hyperplasia, Focal        |                            1                                             |             
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |             
           Focal                           |                                                                          |             
      Subcutaneous Tissue, Necrosis, Fatty,|                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |       3     3                                            3              3|             
      Hemorrhage, Focal                    |             1                          3                                 |             
      Thalamus, Mineralization, Focal      |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +           +  +  +  +     +  +  +  +     +  +  +  +     +     +     +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +           +  +  +  +     +  +  +  +     +  +  +  +     +     +     +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      3                    3                              |             
      Hemorrhage, Focal                    |                      3                    3                              |             
      Inflammation, Chronic, Focal         | 1  1  1  1     1  1     1  1  1  1  1     1  1  2  1  1  1  1  1     1  1|             
      Interstitium, Edema                  |                                                                          |             
      Mediastinum, Congestion              |                                                                          |             
      Mediastinum, Edema                   |                                                                          |             
      Mediastinum, Mineralization, Focal   |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                   2                                                      |             
      Nasolacrimal Duct, Inflammation      |                                                                      2  2|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  A  +  +  +  +  +  A  +  +  +  +  +  A  A  +  A  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   3                                                      |             
      Cataract                             |             2                                                            |             
      Cornea, Necrosis, Focal              |             4                                                            |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                             1            |             
      Hyperplasia, Focal, Histiocytic      |                                     1                    1           2   |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             2  3         |             
      Infarct                              |                                                                4         |             
      Nephropathy                          | 1     1     3  1  1     1  1  1  1  1        2     1  1  1  1  3  1     1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2500 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                          3               |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    1                     |             
      Inflammation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia | 2                                                                        |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7|            |
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3|            |
                                           | 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2500 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  A  +  +  +  +  +  +  +  +  +  +  I  +  +  A  +  +  +  A  +  A  +|  40        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|  42        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Basophilic Focus                     |    X  X     X  X  X  X  X  X           X     X  X     X     X  X  X      |     31     |
      Clear Cell Focus                     |    X        X     X  X  X  X           X     X  X           X            |     23     |
      Degeneration, Cystic, Focal          |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                      X                                X                  |      5     |
      Hepatodiaphragmatic Nodule           | X  X                             X  X                                    |      6     |
      Histiocytosis                        | 3  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  3     2|     48  1.9|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Inflammation, Chronic                |    1        3  2  1  1  2  1        4  2     3  1     3  3  2  1  1     4|     34  1.8|
      Mixed Cell Focus                     |                                                             X            |      6     |
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Dilatation, Focal         |                                                 2                        |      2  2.5|
      Bile Duct, Hyperplasia               | 2  2  3  3  2  2  2  1  1  1  2  3  2  2  1  1  1     3  2  2     3     2|     43  1.9|
      Hepatocyte, Fatty Change, Focal      | 1  3        2  2  3  3        1        1     1  2        1  3     1      |     29  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|       2  4                 2  2  3  1     2        3                     |     17  2.4|
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  3.0|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +                       +  +                 +                    +|  11        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7|            |
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3|            |
                                           | 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2500 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|  47        |
      Acinus, Atrophy, Focal               | 1  2  4  3     1  1  1  3  2  2           1     3     1           2      |     26  1.8|
      Duct, Cyst, Focal, Multiple          |                      1              1     2              1        2      |     11  1.4|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                       1                  |      2  1.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
      Diverticulum                         |                                                          X               |      1     |
      Edema                                |                                           3                              |      2  3.0|
      Inflammation                         |                                                                          |      2  2.0|
      Ulcer                                |          1                                2                              |      3  1.7|
      Epithelium, Hyperplasia              |                      2     2              2                              |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
      Erosion                              |                                                    3                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                       +                  |   4        |
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                   +      |   2        |
      Malformation                         |                                                                   2      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cardiomyopathy                       |    2     2  2  1  2  1  2  2  2     2  1  2  2  2  1  2  2  2  2  2     1|     38  1.8|
      Thrombosis                           |          3                                                               |      2  3.0|
      Artery, Inflammation, Chronic        |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7|            |
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3|            |
                                           | 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2500 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                   1                                                      |      3  1.3|
      Angiectasis                          |                      2        3  3  2           2        3               |      7  2.6|
      Cytoplasmic Alteration, Focal        |                         2                                                |      2  1.5|
      Hemorrhage, Focal                    |                                              3                           |      2  3.0|
      Vacuolization Cytoplasmic, Focal     |    2        1                       1        3           3               |     13  2.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       3                                                                  |      1  3.0|
      Hyperplasia, Focal                   |                                                 2                        |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Atrophy                              |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                    2              2      |      3  2.0|
      Cyst                                 |                                                                          |      2     |
      Pars Distalis, Angiectasis           |                      3              1                                    |      3  2.0|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                2                 1  2        2                           |      5  1.8|
      Pars Distalis, Hemorrhage, Focal     |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                      3                       2                           |      5  2.4|
      Pars Distalis, Hypertrophy, Focal    |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | A  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  A  +  A  +|  40        |
      C-Cell, Hyperplasia                  |    2  1     3  2  2  2  1  2     2  1     1  1  2        3  3     2      |     36  1.9|
      Follicle, Degeneration, Focal        |                   1                                                      |      1  1.0|
      Follicle, Mineralization             |             1        1  1                             1  1  1            |      6  1.0|
      Follicular Cell, Hyperplasia, Focal  |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7|            |
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3|            |
                                           | 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2500 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              | +                                +                 +                     |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                            3     3  3                                    |      5  3.0|
      Hyperplasia, Cystic                  |          2                                                               |      1  2.0|
      Hyperplasia, Focal, Histiocytic      |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Cyst                                 |                                  X                       X               |      5     |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                    +                     |   2        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Ulcer                                |                                                                   4      |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |                3     3  2     2     1  3     3        1        2  2      |     18  2.1|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                           +        +                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperplasia, Focal, Histiocytic      |                                     2                                   2|      2  2.0|
      Hyperplasia                          |                                                                   3      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +           +  +  +  +  +  +  +        +              +     +|  24        |
      Mediastinal, Hemorrhage              |                            3              3                       3      |      5  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
      Pancreatic, Hemorrhage               |                                        2                                 |      2  2.5|
      Pancreatic, Hyperplasia, Histiocytic |             3           3                                               3|      7  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7|            |
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3|            |
                                           | 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2500 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
      Hyperplasia, Lymphoid                |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
      Ectasia                              |                                        3                                 |      2  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +|  47        |
      Accessory Spleen                     |                                                                   X      |      1     |
      Atrophy                              |                                           2                              |      2  2.5|
      Congestion                           |             3                                                            |      1  3.0|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |             4           4              2              2  4              3|     10  3.2|
      Capsule, Infiltration Cellular,      |                                                                          |            |
          Focal, Mixed Cell                |                                              2                           |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |             1              2     2        2     2                        |      8  2.0|
      Hyperplasia                          |                                                    2                     |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal                  |       2                                                                  |      1  2.0|
      Epidermis, Hyperplasia, Focal        |                                                                          |      1  1.0|
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |            |
           Focal                           |       2                                                                  |      1  2.0|
      Subcutaneous Tissue, Necrosis, Fatty,|                                                                          |            |
           Focal                           | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7|            |
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3|            |
                                           | 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2500 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |             3     3        3                    3                        |      8  3.0|
      Hemorrhage, Focal                    |          1                    3                                          |      4  2.0|
      Thalamus, Mineralization, Focal      |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |       +              +              +  +     +     +        +            |  24        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |       +              +              +  +     +     +        +            |  24        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  |                                                                         +|   1        |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                3         |      3  3.0|
      Hemorrhage, Focal                    |                                                                          |      2  3.0|
      Inflammation, Chronic, Focal         |    1  1  1     1  1  1  1  1     1  1  1  1  1  1     1     1     1     1|     39  1.0|
      Interstitium, Edema                  |                                                                      2   |      1  2.0|
      Mediastinum, Congestion              | 3                                                                        |      1  3.0|
      Mediastinum, Edema                   |                                                                      3   |      1  3.0|
      Mediastinum, Mineralization, Focal   |                                                                      3   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation      |    2                                                                    2|      4  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7|            |
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3|            |
                                           | 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    2500 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | A  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  A  +|  40        |
      Atrophy                              |                   3                                      4               |      3  3.3|
      Cataract                             |                                                                          |      1  2.0|
      Cornea, Necrosis, Focal              |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  1.0|
      Hyperplasia, Focal, Histiocytic      |             1                                                           1|      5  1.2|
      Epithelium, Hyperplasia, Focal       |                                                                         1|      1  1.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                   +      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  A  +|  43        |
      Cyst                                 |                                                                          |      2  2.5|
      Infarct                              |                                                                          |      1  4.0|
      Nephropathy                          |    1  1     1  1  1  1  1  1     1     1  1  1  1     1  1  1     1     1|     36  1.1|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |       2                                                                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation                         |                                           3                              |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|             
                                           | 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X     X     X     X  X  X              X        X  X        X   |             
      Clear Cell Focus                     |                   X  X     X  X  X     X     X     X  X  X  X     X  X  X|             
      Congestion                           |                                                                3         |             
      Degeneration, Cystic, Focal          |                                           2              4     3         |             
      Eosinophilic Focus                   | X        X              X                    X  X  X     X        X      |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           | X  X     X              X           X                       X            |             
      Histiocytosis                        | 3  4  3  3  2  2  3  3  2  2  2  2  3  2  2  2  2  2  2  2  3  3  3  2  3|             
      Hyperplasia, Focal, Histiocytic      |                                  2                                       |             
      Infiltration Cellular, Mixed Cell    |                2                                            1        1   |             
      Inflammation, Chronic                | 3        2     1  3  2     1  1  2     1  4  2     1  1  1  2  1  2  1  2|             
      Mixed Cell Focus                     |          X     X     X     X  X  X                 X     X  X        X   |             
      Bile Duct, Cyst                      |                X                                                         |             
      Bile Duct, Dilatation, Focal         |             2                                                            |             
      Bile Duct, Hyperplasia               | 2     2  2  3  1     2     2     1        1  2        2  2  2  1         |             
      Hepatocyte, Fatty Change, Focal      |                3  2  2     2  2  2     2  2        2  2  2  2  2  2     3|             
      Hepatocyte, Necrosis, Focal          |                                     2                                    |             
      Hepatocyte, Vacuolization Cytoplasmic|          3                          2           3                    3   |             
      Hepatocyte, Centrilobular, Necrosis  |       4                                                                  |             
      Oval Cell, Hyperplasia, Focal        |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +           +                       +                        |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|             
                                           | 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
      Lymphatic, Angiectasis               |             2                                                            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               | 3        1  2     3  1  2     1  3              2  1  2  2     2        3|             
      Duct, Cyst, Focal, Multiple          |          2                 2        1     2                          2   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          3                                                               |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                1         |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Tongue                                  | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |             +                                                            |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  3  2  2  2  2  2     1  3  1  2  2  3  1     2  1  3  2  4  2  2  1|             
      Thrombosis                           |       3                                   3              3     4         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                  1                                       |             
      Angiectasis                          |                                           3                              |             
      Cytoplasmic Alteration, Focal        |          3                                                               |             
      Hemorrhage, Focal                    |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |    2           2           1                       2                 2   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|             
                                           | 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Angiectasis                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       3  2        3      |             
      Cyst                                 |                                           X     X                       X|             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                                                                         1|             
      Pars Distalis, Hyperplasia, Focal    | 3                             1                       1                  |             
      Pars Distalis, Hypertrophy, Focal    |                      1              1                                    |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             
      C-Cell, Hyperplasia                  | 3        2  2     1  1  1  3  3  1        1  1  1  3  1  1              2|             
      Follicle, Degeneration, Focal        |                                                                          |             
      Follicle, Mineralization             |             1     1                          1     1        1     1     1|             
      Follicular Cell, Hyperplasia, Focal  | 2                                                        2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                    3                     |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic                |                   2              1                                       |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      3                                                   |             
      Periovarian Tissue, Hemorrhage       |                                                                3         |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                          +               |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|             
                                           | 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |       1     1  2  2     1  2  2  2  1     2  2              1  1  1      |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                  +                                       |             
      Angiectasis                          |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3                                    |             
      Hyperplasia, Focal, Histiocytic      |                      2                                2                  |             
      Hyperplasia                          |                                                          2               |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +  A  +  +  +     +  +     +  +  +     +  +  +     +  +  +     +  +   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                  3        3                              |             
      Mediastinal, Hyperplasia, Histiocytic|                3     3                                3  3           3   |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Pancreatic, Hemorrhage               |                               3                          3               |             
      Pancreatic, Hyperplasia, Histiocytic |                                     3     4                 3        3   |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  M  M  +  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M|             
      Hyperplasia, Histiocytic             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          3               |             
      Hyperplasia, Histiocytic             |                      3                                3                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |             X                                                            |             
      Fibrosis, Focal                      |                                                                          |             
      Inflammation, Granulomatous          |                                           1                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|             
                                           | 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Capsule, Infiltration Cellular,      |                                                                          |             
          Focal, Mixed Cell                |                                                             1            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                     3                                    |             
      Epidermis, Hyperplasia, Focal        |    3                                2                                    |             
      Lip, Cyst Epithelial Inclusion       |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |          2                                                               |             
      Hemorrhage, Focal                    |                                                 2                        |             
      Meninges, Hemorrhage, Focal          |                         3                                                |             
      Thalamus, Mineralization, Focal      |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|             
                                           | 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     2  3                       2         |             
      Hemorrhage, Focal                    |                                        2        2                        |             
      Hyperplasia, Focal, Histiocytic      |                3                                                         |             
      Infiltration Cellular, Mixed Cell    |                                        3                                 |             
      Inflammation, Chronic, Focal         | 1  1  1  1  1  1  1  1     1  1  1  2     4  2     1  1  1  1  1  2  1  1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                          2        1      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Hemorrhage        |                                                             1            |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Atrophy                              | 3              4                             3                           |             
      Cataract                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Synechia                             |                               3                                          |             
      Anterior Chamber, Exudate            |                                                                          |             
      Cornea, Necrosis, Focal              |                               3           4                              |             
      Retina, Degeneration                 |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  A  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |             2                                                            |             
      Nephropathy                          | 4        1  2  1  1  1  1  1  1  1        1  1     1  1  1  1     1  1  1|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                           3                              |             
      Renal Tubule, Hyperplasia, Focal     |                                                             2            |             
      Renal Tubule, Pigmentation           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|             
                                           | 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    5000 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4|            |
                                           | 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    5000 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|  43        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X              X  X  X     X     X  X     X  X  X  X     X     X  X     X|     25     |
      Clear Cell Focus                     | X  X  X        X  X  X           X  X     X     X        X     X  X      |     27     |
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Cystic, Focal          |                                                                          |      3  3.0|
      Eosinophilic Focus                   |       X              X                             X                     |     11     |
      Hemorrhage                           |                               2                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |    X                                   X  X  X                          X|     11     |
      Histiocytosis                        | 3  3  3  3  2  3  3  3  3  3  2  2  3  2  2  3  2  3  2  2  2  2  3  3  3|     50  2.5|
      Hyperplasia, Focal, Histiocytic      |                                  2                                       |      2  2.0|
      Infiltration Cellular, Mixed Cell    |                2                 2                                       |      5  1.6|
      Inflammation, Chronic                | 2  2  2        1  1  2  1  2     1  3           1     1     1  2  2     2|     35  1.7|
      Mixed Cell Focus                     |                X  X  X     X     X        X     X                       X|     18     |
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Dilatation, Focal         |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2  2  3  2  1     1     2  2  1  2  2     2  2  3     1  2  3  2  2  2  1|     35  1.9|
      Hepatocyte, Fatty Change, Focal      | 3  3  3        2  2  3  1     2  2        2  1  3  2     2     2  3     2|     32  2.2|
      Hepatocyte, Necrosis, Focal          |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|          1  2                       2        2           2           3  3|     11  2.4|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4|            |
                                           | 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    5000 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Centrilobular, Necrosis  |                                                                          |      1  4.0|
      Oval Cell, Hyperplasia, Focal        |                         2                                   2            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                        +  +        +  +              +   |   8        |
      Fat, Necrosis, Focal                 |                                           1                              |      1  1.0|
      Lymphatic, Angiectasis               |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Acinus, Atrophy, Focal               | 1  1        1     1  1     1     2     3  3  1  1  3     1     1     2  1|     30  1.7|
      Duct, Cyst, Focal, Multiple          |                   1     1     2                                      2   |      9  1.7|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                      3   |      1  3.0|
      Ulcer                                |                                                                      1   |      2  1.0|
      Epithelium, Hyperplasia              |                                                                      1   |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                        2              1              1   |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                     +                       +            |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  1  2  2     2  2  2     2  2  1  2  1  2  2  1     1  1  2  2  2     3|     44  1.9|
      Thrombosis                           |          4                                                               |      5  3.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4|            |
                                           | 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    5000 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                1                                                         |      2  1.0|
      Angiectasis                          |                   2  3                                   3               |      4  2.8|
      Cytoplasmic Alteration, Focal        |             1                                                            |      2  2.0|
      Hemorrhage, Focal                    |                                              3                           |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |    1              2  2                          1     1     2           1|     12  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                 2                        |      4  2.5|
      Cyst                                 |                                                             X           X|      5     |
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |       1                                                           3      |      3  1.7|
      Pars Distalis, Hyperplasia, Focal    |                                                 3                        |      4  2.0|
      Pars Distalis, Hypertrophy, Focal    |       3                                                                 1|      4  1.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
      C-Cell, Hyperplasia                  | 1  3        1  2  2  2  2  1  2  2  2  1        1  1        3  1  1  1  3|     35  1.7|
      Follicle, Degeneration, Focal        |                   1                                                      |      1  1.0|
      Follicle, Mineralization             | 1  1  1                       1  1  1     1     1        1  1  1        1|     19  1.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                         +     +        +           +  +                  |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4|            |
                                           | 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    5000 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                               2           2                              |      3  2.3|
      Hyperplasia, Cystic                  |                                                                3         |      1  3.0|
      Inflammation, Chronic                |                                                 2                        |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                         3|      2  3.0|
      Periovarian Tissue, Hemorrhage       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     | 1  1  1           2  2           1        2              1     2  1  3  2|     26  1.5|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +                       +                    +                           |   4        |
      Angiectasis                          |                                              3                           |      1  3.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                    3                     |      2  3.0|
      Hyperplasia, Focal, Histiocytic      |                                     2                                    |      3  2.0|
      Hyperplasia                          |    3                                                                     |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +     +  +  +     +  +  +        +  +  +     +     +  +  +     +  +|  35        |
      Hyperplasia, Plasma Cell             |                3                                                         |      1  3.0|
      Mediastinal, Ectasia                 |                                                                3         |      1  3.0|
      Mediastinal, Hemorrhage              |                                              3                           |      3  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                                3         |      6  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                         3|      1  3.0|
      Pancreatic, Hemorrhage               |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4|            |
                                           | 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    5000 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Pancreatic, Hyperplasia, Histiocytic |    3  3                                   3                              |      7  3.1|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                         3|      1  3.0|
      Renal, Hyperplasia, Histiocytic      |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   4        |
      Hyperplasia, Histiocytic             |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                         3|      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Accessory Spleen                     |                                                                          |      1     |
      Fibrosis, Focal                      |                                                          2               |      1  2.0|
      Inflammation, Granulomatous          |    2                       2                                             |      3  1.7|
      Capsule, Infiltration Cellular,      |                                                                          |            |
          Focal, Mixed Cell                |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                                                         3|      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                              2                           |      1  2.0|
      Hyperplasia                          |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  3.0|
      Epidermis, Hyperplasia, Focal        |                                                                          |      2  2.5|
      Lip, Cyst Epithelial Inclusion       |                                                                      2   |      1  2.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4|            |
                                           | 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    5000 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                                              3                           |      2  2.5|
      Hemorrhage, Focal                    |                                        1                                 |      2  1.5|
      Meninges, Hemorrhage, Focal          |                                                                          |      1  3.0|
      Thalamus, Mineralization, Focal      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                                        3              3                  |      2  3.0|
      Necrosis, Focal                      |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |          2                                   2                           |      5  2.2|
      Hemorrhage, Focal                    |                                                                          |      2  2.0|
      Hyperplasia, Focal, Histiocytic      |                               3                                          |      2  3.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         | 1  1  1     1     1  2  1  1  3  1  1     1     1  2  1  1  1  1  1  1  1|     43  1.2|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Hemorrhage        |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation      |                   3  3     3                                2     2      |      5  2.6|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4|            |
                                           | 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    5000 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
      Atrophy                              |                3                                                         |      4  3.3|
      Cataract                             |                      3                                                   |      1  3.0|
      Inflammation, Chronic                |                      3                                                   |      1  3.0|
      Synechia                             |                         3                                                |      2  3.0|
      Anterior Chamber, Exudate            |                   3                                                      |      1  3.0|
      Cornea, Necrosis, Focal              |                                                                          |      2  3.5|
      Retina, Degeneration                 |                      3              3                                    |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|  43        |
      Hydronephrosis                       | 2                                                                        |      1  2.0|
      Infarct                              |                2                                                         |      2  2.0|
      Nephropathy                          | 2  1  1        3  1  1  2  1  2  1  1     1     1        3  1  1  1  3  2|     38  1.4|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                               3                                      3   |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                        3              3                  |      2  3.0|
      Inflammation                         | 2                                                                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|             
                                           | 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X     X     X     X              X  X  X  X     X  X  X  X  X     X  X|             
      Clear Cell Focus                     |    X     X     X     X  X           X  X  X  X     X  X  X  X  X     X  X|             
      Congestion                           |                                     3                                    |             
      Degeneration, Cystic, Focal          |                                                                1         |             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis                             |                2                                                         |             
      Hepatodiaphragmatic Nodule           | X                                                                 X      |             
      Histiocytosis                        |    1     1           1  1  2  1  1  1  1  1        1  1  1     1  1  1  1|             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Infiltration Cellular, Mixed Cell    |    2     2     1     2  1           1        1     1  1     1            |             
      Inflammation, Chronic                |                      1              1                 1  2     1  1     1|             
      Inflammation, Granulomatous          |    1                                                                     |             
      Mixed Cell Focus                     | X  X     X                                            X                  |             
      Bile Duct, Dilatation, Focal         |                                              2        1                  |             
      Bile Duct, Hyperplasia               | 3  2  3  3  3  3  3  2  2  4  2  3  2  2  3  3  3  3  2  3  3  3  2  3  3|             
      Hepatocyte, Fatty Change, Focal      | 1                       1                 1  2  1  2           2  2  1  2|             
      Hepatocyte, Vacuolization Cytoplasmic|       3     3  1  3     2  2  1  3  2                                    |             
      Serosa, Inflammation, Chronic, Focal |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                 +        +     +        +                 +  +         |             
      Fat, Hemorrhage, Focal               |                                                             2            |             
      Fat, Necrosis, Focal                 |                   3              3        3                    3         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|             
                                           | 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               | 3     3     1  3  2  1        1  1           2     1  1        2  1     2|             
      Duct, Cyst, Focal, Multiple          |          1     2     1           2  2        1     1                 2   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                   3              3                                       |             
      Inflammation                         |                                        2                                 |             
      Ulcer                                |             2     2        1     3     2                                 |             
      Epithelium, Hyperplasia              |             2     3                    2                                 |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                   2        3                                             |             
      Erosion                              |                            3                                             |             
      Ulcer                                |             2                                                            |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
      Peridontal Tissue, Inflammation      |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1     1     2     2  2  2     3  2     2  1  2  2  2  2  1        2  2|             
      Thrombosis                           |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                        2     1        1     1            |             
      Cytoplasmic Alteration, Focal        |          1                                                               |             
      Hematopoietic Cell Proliferation     |                3                                                         |             
      Hemorrhage, Focal                    |                                                                          |             
      Necrosis                             |             2                                                            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|             
                                           | 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                      1                                                  1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2                                                  2               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Focal                   |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |          X  X                                      X                    X|             
      Pars Distalis, Hemorrhage, Focal     |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                       2                  |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Hypertrophy, Focal    |       2  1                          2           1              1  3  2   |             
      Pars Nervosa, Inflammation           |                         1                                                |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1     2  1  1  1  2  2  1  1  1  1  2  1  2  2     2  1  1  2  1  1  2  1|             
      Follicle, Degeneration, Focal        |    1                                         1              1            |             
      Follicle, Mineralization             |                                           1                              |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              | +     +              +     +                                             |             
      Mediastinum, Cyst                    |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                        3                                 |             
      Spermatocele                         |                                        3                                 |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|             
                                           | 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Degeneration, Cystic                 |                                     3  2                    3            |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Cystic                  |                2                                                         |             
      Inflammation, Chronic                | 2  1                 1  2           2     2        2  2  2  2  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1  2  1  1  1     1  1     2        1        2  1  1     3  1  2     3|             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3        3     3        3        3        3  3                  |             
      Cyst                                 |                                                                          |             
      Interstitial Cell, Hyperplasia, Focal|                            1     2                                2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                  3                                       |             
      Hyperplasia                          |                3                       3                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +     +  +  +        +  +  +     +        +                 +      |             
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |             
          Cell                             |                                        3                                 |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                        3                          3      |             
      Mediastinal, Hyperplasia, Histiocytic|                3                                                  3      |             
      Mediastinal, Hyperplasia, Plasma Cell|                                  3                                       |             
      Pancreatic, Ectasia                  |                                        2                                 |             
      Pancreatic, Hyperplasia, Histiocytic |                3                       2                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Histiocytic             |                3                 3                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|             
                                           | 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                   X                                      X     X         |             
      Atrophy                              |                                  3                                       |             
      Fibrosis, Diffuse                    |                                  3                                       |             
      Fibrosis, Focal                      |                                                                         3|             
      Hematopoietic Cell Proliferation     |                3                                                         |             
      Hemorrhage                           |       4                                                                  |             
      Hyperplasia, Lymphoid                |                2                                                         |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |             1     2  3     2  2                                          |             
      Fibrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vertebra, Cyst                       |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                               3                                          |             
      Hemorrhage, Focal                    |                   2                                                      |             
      Meninges, Hemorrhage, Focal          |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                        +                                 |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                        +                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|             
                                           | 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                    3                                    |             
      Hemorrhage, Focal                    |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                2                                      1                  |             
      Inflammation, Chronic, Focal         |                      1                                1                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                  3                                       |             
      Inflammation, Suppurative            |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Histiocytic      |                                                          3               |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                         +              +                          +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                             2           2|             
      Nephropathy                          | 2  1  1  2  2  2  2  2  1  3  3  1  1  2  1  2  1  2  2  2  1  1  1  1  3|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                   2                                                      |             
      Renal Tubule, Pigmentation           |             2                                                            |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|             
                                           | 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   3                                                      |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                   3                                                      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3|            |
                                           | 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  A  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  A  +|  46        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X        X  X  X  X  X  X     X        X  X  X     X  X           X  X|     31     |
      Clear Cell Focus                     | X  X        X  X  X     X  X  X     X     X  X  X     X  X              X|     31     |
      Congestion                           |                                                 1                        |      2  2.0|
      Degeneration, Cystic, Focal          | 1                                            2                 1         |      4  1.3|
      Eosinophilic Focus                   |                X        X  X                    X                        |      4     |
      Fibrosis                             |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                     X              X                 X   |      5     |
      Histiocytosis                        | 1  1  1  1  1  1  1  1  1  1     1  1  2  1  1  1  2  1  1        1     1|     38  1.1|
      Hyperplasia, Focal, Histiocytic      |                                                          1               |      1  1.0|
      Infiltration Cellular, Mixed Cell    |                         1        1        1     1        1               |     15  1.2|
      Inflammation, Chronic                | 1  1           2  1        1  1  1        1  1  1        1               |     18  1.1|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                            X                                             |      5     |
      Bile Duct, Dilatation, Focal         |                                                                          |      2  1.5|
      Bile Duct, Hyperplasia               | 3  3  3  4  3  3  3  3  2  2  3  3  2  3  3  3  3  2  3  3  3     3     3|     48  2.8|
      Hepatocyte, Fatty Change, Focal      | 2  2           1     1        2  1        2  1  1     1     3            |     21  1.5|
      Hepatocyte, Vacuolization Cytoplasmic|                                        2                             2   |     11  2.2|
      Serosa, Inflammation, Chronic, Focal |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3|            |
                                           | 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +              +              +  +                    +           +|  13        |
      Fat, Hemorrhage, Focal               |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |       3              3              2                       2           3|      9  2.8|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                      +   |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Focal               | 1  3  2  1  2        2              2              1           2         |     23  1.7|
      Duct, Cyst, Focal, Multiple          |                2     3  1        2              2           1  2         |     15  1.7|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                        3                                 |      3  3.0|
      Inflammation                         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      5  2.0|
      Epithelium, Hyperplasia              |                                        3                                 |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      2  2.5|
      Erosion                              |                                                             1     1      |      3  1.7|
      Ulcer                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  1  2  2  2  2  1  1     1  1  1  1     2  2  2  2  2  1  2  2  2     2|     40  1.7|
      Thrombosis                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3|            |
                                           | 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                1                    1     1              2  1            |      9  1.2|
      Cytoplasmic Alteration, Focal        |       1                                   1                              |      3  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hemorrhage, Focal                    |       2                                                                  |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                   2        1                    2              1         |      6  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                1     2        1        1                       1         |      7  1.4|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                 2                        |      1  2.0|
      Cyst                                 |                                                                          |      4     |
      Pars Distalis, Hemorrhage, Focal     |                      3                                         2         |      2  2.5|
      Pars Distalis, Hyperplasia, Focal    |                                              3                 2         |      3  2.3|
      Pars Distalis, Hyperplasia           |                            3                                             |      1  3.0|
      Pars Distalis, Hypertrophy, Focal    | 2                                                                        |      8  1.8|
      Pars Nervosa, Inflammation           |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  A  +|  47        |
      C-Cell, Hyperplasia                  | 2  2        1  2  1  1  1  1  2  2  2  1  2  4  1     1  2              2|     41  1.5|
      Follicle, Degeneration, Focal        |             1  1                    1                                    |      6  1.0|
      Follicle, Mineralization             |                                                 1                       1|      3  1.0|
      Follicular Cell, Hyperplasia, Focal  |                                                          1               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3|            |
                                           | 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                        +                    +            |   6        |
      Mediastinum, Cyst                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
      Spermatocele                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                             3     3      |      5  2.8|
      Fibrosis                             |                                                                   3      |      1  3.0|
      Hyperplasia, Cystic                  |                   3     2                                                |      3  2.3|
      Inflammation, Chronic                | 1           2  1  3  1  2  1     3  2     2  1  2           2  1     1  1|     30  1.6|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 1  3  1              2           2     2  3     1     1           3  3   |     27  1.7|
      Epithelium, Hyperplasia, Focal       |       2                 1                    1                       1   |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    3              3        3     3                 3     3     3        3|     15  3.0|
      Cyst                                 |    3                                                                     |      1  3.0|
      Interstitial Cell, Hyperplasia, Focal|                                           2                              |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |             3                                                            |      1  3.0|
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3|            |
                                           | 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node                              |       +  +           +     +  +     +  +        +           +            |  19        |
      Deep Cervical, Hyperplasia, Plasma   |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
      Mediastinal, Ectasia                 |          3                 3                                             |      2  3.0|
      Mediastinal, Hemorrhage              |                            3                                             |      3  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                      3        3                 3                        |      5  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                               3                                          |      2  3.0|
      Pancreatic, Ectasia                  |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |          3                                                               |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      3     |
      Atrophy                              |                                                    1              3      |      3  2.3|
      Fibrosis, Diffuse                    |                                                                          |      1  3.0|
      Fibrosis, Focal                      |                                        3                                 |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |       2                                                     3            |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Dilatation                           |    2                 4           2  2  2  3                          3   |     12  2.3|
      Fibrosis                             |                                                    2                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3|            |
                                           | 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |          3                                                               |      1  3.0|
      Hyperkeratosis, Focal                |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vertebra, Cyst                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                                        3  3                          3   |      4  3.0|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Meninges, Hemorrhage, Focal          |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |          +                                                               |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |          +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 2                                                                    3   |      4  2.8|
      Hemorrhage, Focal                    |       3                                                  1           2  3|      4  2.3|
      Infiltration Cellular, Mixed Cell    |    2                                                                     |      3  1.7|
      Inflammation, Chronic, Focal         |                                                 2                        |      3  1.3|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |             2                    2                                       |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                      2   |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                      2   |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3|            |
                                           | 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Cataract                             |          3                                      3                        |      2  3.0|
      Retina, Degeneration                 |          3                                      3                        |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  3.0|
      Epithelium, Hyperplasia, Focal       |                                           2                              |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  48        |
      Congestion                           |                                                                      3   |      1  3.0|
      Cyst                                 |                                                                          |      2  2.0|
      Nephropathy                          | 2  2     1  2  2  2  2  1  1  2  2  1  1  2  2  1     2  1  1  1  1     1|     47  1.6|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation                         |                                                                1         |      1  1.0|
      Ulcer                                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 2| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 1| 7| 3| 4| 3| 3|             
                                           | 4| 3| 4| 0| 0| 0| 0| 7| 0| 0| 0| 0| 4| 4| 4| 4| 1| 4| 4| 6| 5| 0| 7| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    625 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
      Congestion                           |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                2                                                         |             
      Basophilic Focus                     | X     X  X              X  X  X  X     X  X  X     X           X     X   |             
      Clear Cell Focus                     | X     X  X              X  X  X  X     X  X  X     X  X        X     X   |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Eosinophilic Focus                   |                               X                                          |             
      Hepatodiaphragmatic Nodule           |                                        X                                 |             
      Histiocytosis                        | 1        2  1     1     1  1  1  1     1  1  1  1  1  1  2  1  1  2  2  1|             
      Infiltration Cellular, Mixed Cell    |       1                          1     2                    1            |             
      Inflammation, Chronic                | 1     1  1              1  1  1        1     1     1     1  1  2  1  1   |             
      Mixed Cell Focus                     |       X                       X                                X     X   |             
      Bile Duct, Dilatation, Focal         |                         2                                                |             
      Bile Duct, Hyperplasia               | 3  4  3  3  3  3  3  3  3  3  3  3  3  3  3  3  2  3  3  2     3  2  3  2|             
      Hepatocyte, Fatty Change, Focal      | 2     2  2              1  3  2  1     3  3  3     2  1        2         |             
      Hepatocyte, Necrosis, Focal          |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|    3           3  3  2                          4                       4|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +                 +                                                   |             
      Fat, Necrosis, Focal                 | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                             +            |             
      Foreign Body                         |                                                             3            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 2| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 1| 7| 3| 4| 3| 3|             
                                           | 4| 3| 4| 0| 0| 0| 0| 7| 0| 0| 0| 0| 4| 4| 4| 4| 1| 4| 4| 6| 5| 0| 7| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    625 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Inflammation, Chronic, Focal         |                                                             3            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
      Acinus, Atrophy, Focal               | 1     2     1  1  1     2  1     2  1     1        1  2              2   |             
      Duct, Cyst, Focal, Multiple          |                            1        2              2              2  1   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Focal                |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Ulcer                                |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                   +      |             
      Epithelium, Cyst                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     2  2  2     2     2  1     1     1  1  2     1  2        1  2  2  2|             
      Thrombosis                           |    3                                            3                       3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                      1  2                                                |             
      Angiectasis                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 2| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 1| 7| 3| 4| 3| 3|             
                                           | 4| 3| 4| 0| 0| 0| 0| 7| 0| 0| 0| 0| 4| 4| 4| 4| 1| 4| 4| 6| 5| 0| 7| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    625 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                       1                  |             
      Degeneration, Cystic                 |       4                                                                  |             
      Necrosis                             |    4                                                                     |             
      Vacuolization Cytoplasmic, Focal     |                1  2           2                       1                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                            1                                             |             
      Necrosis                             |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                                         |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hypertrophy, Focal    | 2  1        1                                               2     3      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
      C-Cell, Hyperplasia                  | 1     1  2  1  2  2  2  1  2  1  1  1  2  1  2        1     1  1     3   |             
      Follicle, Cyst                       |                                  X                                X      |             
      Follicle, Degeneration, Focal        |                1                    1                                    |             
      Follicle, Mineralization             |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                      +                                                   |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 2| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 1| 7| 3| 4| 3| 3|             
                                           | 4| 3| 4| 0| 0| 0| 0| 7| 0| 0| 0| 0| 4| 4| 4| 4| 1| 4| 4| 6| 5| 0| 7| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    625 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Degeneration, Cystic                 |                                        3                                 |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic                | 2  3     1  1     1        2  1  2  2        1        2        2     2  2|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2  1     1     3     1  3     1        2  3                 1  3     2|             
      Epithelium, Hyperplasia, Focal       |                                  1                 1     1        2      |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3  3                 3                 3              3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +     +     +        +           A           +     +     A|             
      Hyperplasia, Plasma Cell             |                                                             3            |             
      Mediastinal, Ectasia                 |       1                                                           3      |             
      Mediastinal, Hemorrhage              |                            3                                             |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                             4            |             
      Pancreatic, Hemorrhage               |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
      Ectasia                              |                                                             3            |             
      Hyperplasia, Histiocytic             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                  3                                       |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Granulomatous          |                                                    3                     |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 2| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 1| 7| 3| 4| 3| 3|             
                                           | 4| 3| 4| 0| 0| 0| 0| 7| 0| 0| 0| 0| 4| 4| 4| 4| 1| 4| 4| 6| 5| 0| 7| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    625 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Dilatation                           |                   4        3                 3                           |             
      Inflammation, Chronic, Focal         |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                                          |             
      Epidermis, Hyperplasia, Focal        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                   3        3                 3                           |             
      Hemorrhage, Focal                    |    2                 3                                                   |             
      Meninges, Congestion, Focal          |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                      +                                   +               |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                      +                                   +               |             
      Hemorrhage, Focal                    |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage, Focal                    |                                                 3                        |             
      Inflammation, Chronic, Focal         |       1              3                                                   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 2| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 1| 7| 3| 4| 3| 3|             
                                           | 4| 3| 4| 0| 0| 0| 0| 7| 0| 0| 0| 0| 4| 4| 4| 4| 1| 4| 4| 6| 5| 0| 7| 0| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    625 PPM                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
           Focal                           |                                  1                                2      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                             +            |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
      Cataract                             |                                                             3            |             
      Anterior Chamber, Exudate            |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                        +                                 |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Cyst                                 |                                                                          |             
      Infarct                              |    4                                                                     |             
      Nephropathy                          | 1  3  1  1     1        1  2  1  1     2  1  2  2  2  2     1  2  3  2   |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                2  1                                                      |             
      Renal Tubule, Hyperplasia, Focal     |             1                                                            |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3|            |
                                           | 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    625 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
      Congestion                           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Basophilic Focus                     | X        X     X  X  X  X     X        X     X  X        X  X     X      |     26     |
      Clear Cell Focus                     | X        X     X  X  X        X  X  X  X     X        X  X  X     X      |     28     |
      Degeneration, Cystic, Focal          |                            2           1                             1   |      3  1.3|
      Eosinophilic Focus                   |                                                       X                 X|      3     |
      Hepatodiaphragmatic Nodule           |                                                                X         |      2     |
      Histiocytosis                        | 2  2  2  2  1  2  1  1  2  1  1  2  2  1  1  1  2  1  1  1  2  2  1  2  1|     45  1.4|
      Infiltration Cellular, Mixed Cell    |                                                          1               |      5  1.2|
      Inflammation, Chronic                | 2  1     1     1  1  1  1     1  2  2  1     1  1     1  1  2  1  1      |     32  1.2|
      Mixed Cell Focus                     |                                  X                    X  X               |      7     |
      Bile Duct, Dilatation, Focal         |                2                                                         |      2  2.0|
      Bile Duct, Hyperplasia               | 3  3  3  3  3  3  3  2  2  3  3  3  3  3     3  3  3  3  3  2  2  3  3  3|     48  2.9|
      Hepatocyte, Fatty Change, Focal      | 1        1           1  3              2     1  2        1  1  2  1      |     24  1.8|
      Hepatocyte, Necrosis, Focal          |                                                 2              2         |      2  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|    3  2     3              2     3                 3  2              3   |     14  2.9|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +           +              +                 +  +              +        +|  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3|            |
                                           | 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    625 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Necrosis, Focal                 | 3                                            4                 2         |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Foreign Body                         |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Atrophy, Focal               | 1     2  3           2     2  2  1     3     1     2                 3   |     24  1.7|
      Duct, Cyst, Focal, Multiple          | 1  2                             2     2                 2  2        2   |     12  1.8|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis, Focal                |                                                                2         |      1  2.0|
      Ulcer                                |    3                                               3                     |      2  3.0|
      Epithelium, Hyperplasia              |    3                                               3                     |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                    2                     |      1  2.0|
      Inflammation, Focal                  |    2                                                                     |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |       +                                                                 +|   3        |
      Epithelium, Cyst                     |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   1        |
      Peridontal Tissue, Inflammation      |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                        +                                 |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3|            |
                                           | 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    625 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Cardiomyopathy                       | 2  2  1     2  2  2  2     1  1  2  2  2     2  1  1  2  3  1     2  2  1|     38  1.7|
      Thrombosis                           |                                                                          |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                   1        1        1        1                           |      6  1.2|
      Angiectasis                          |                                                             2            |      1  2.0|
      Cytoplasmic Alteration, Focal        |                                                       2                  |      2  1.5|
      Degeneration, Cystic                 |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic, Focal     |                                     1                                    |      5  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |       X                                                                  |      2     |
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |          2                                                               |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                      2                                                   |      1  2.0|
      Pars Distalis, Hypertrophy, Focal    |                                              1        2  1        1      |      9  1.6|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
      C-Cell, Hyperplasia                  | 1  2  1           4  4        1  1                          1  1         |     28  1.6|
      Follicle, Cyst                       |                X                                                         |      3     |
      Follicle, Degeneration, Focal        | 1                                   3                                    |      4  1.5|
      Follicle, Mineralization             |                         1                                1              1|      3  1.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3|            |
                                           | 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    625 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                 +                        |   2        |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                        +  +|   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                3  2      |      3  2.7|
      Hyperplasia, Cystic                  |          2                                                               |      1  2.0|
      Inflammation, Chronic                | 2     1  2  1  1  2     2  2     1  1        2           2  1        1   |     28  1.6|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    3     1        1     3  3  2        2              2     1  3     2  2|     24  2.0|
      Epithelium, Hyperplasia, Focal       |                                     1                          2         |      6  1.3|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       3        3           3           1        3                        |     10  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          3                                3     2                        |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +              +                       +        +        +  +|  18        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Mediastinal, Ectasia                 |                                                                          |      2  2.0|
      Mediastinal, Hemorrhage              |                                                             3            |      2  3.0|
      Mediastinal, Hyperplasia             |          3                                                               |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|    4                                                                     |      2  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3|            |
                                           | 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    625 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Pancreatic, Hemorrhage               |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia                              |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosis, Focal                      |                                                                      3   |      2  3.0|
      Hematopoietic Cell Proliferation     |          3                                                               |      1  3.0|
      Infarct                              |                                                                      3   |      1  3.0|
      Inflammation, Granulomatous          |          3                                                               |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +|  46        |
      Dilatation                           |                         2                                      2     2  2|      7  2.6|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                          2               |      1  2.0|
      Ulcer                                |    3                                                                     |      1  3.0|
      Epidermis, Hyperplasia, Focal        |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                         +|   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3|            |
                                           | 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    625 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |    3                    3                                      4         |      6  3.2|
      Hemorrhage, Focal                    |             2                                      3                     |      4  2.5|
      Meninges, Congestion, Focal          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                         +                                                |   3        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                                |   3        |
      Hemorrhage, Focal                    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                               2                                          |      1  2.0|
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |                               2                                          |      3  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                   2                          2                           |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                         1|      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Cataract                             |                                                                          |      1  3.0|
      Anterior Chamber, Exudate            |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3|            |
                                           | 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    625 PPM                                | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |       3                                                                  |      1  3.0|
      Infarct                              |                                  1                                       |      2  2.5|
      Nephropathy                          | 1  1  1  3     1  1  1  3  2  2  1  2  1  1  2  2  1  1  2  1  2  1  2  2|     43  1.6|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                 3                        |      3  2.0|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |                                                 3                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                    3                     |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 4| 3| 3| 3| 9| 3| 3| 3| 9| 0| 4| 0| 3| 3| 3| 3| 3| 5| 3| 1| 3|             
                                           | 0| 0| 4| 4| 2| 4| 4| 4| 4| 8| 5| 5| 3| 5| 2| 6| 0| 0| 0| 0| 0| 3| 4| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                 2                        |             
      Basophilic Focus                     | X  X     X     X     X     X           X        X  X  X  X  X     X     X|             
      Clear Cell Focus                     | X  X     X     X  X  X                          X  X  X  X  X     X     X|             
      Degeneration, Cystic, Focal          |                                                                          |             
      Eosinophilic Focus                   |    X     X           X        X                          X               |             
      Hepatodiaphragmatic Nodule           |          X              X                    X                           |             
      Histiocytosis                        | 2  2  2  2  2  2  2  2  2  1  1  2  2  2  1  2  2  2  2  1  2  2  2  2  2|             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Infiltration Cellular, Mixed Cell    |          1     2                                         2               |             
      Inflammation, Chronic                | 2  1     1     1  2     2  1                    1  1  2  1  2     2     1|             
      Mixed Cell Focus                     | X  X     X        X        X                             X              X|             
      Thrombosis                           |                                           3                              |             
      Bile Duct, Dilatation, Focal         |                                                             1            |             
      Bile Duct, Hyperplasia               | 3  2  3  3  3  3  3  3  3  2  3  3  2  3  3  3  3  3  3  3  3  3  3  2  3|             
      Hepatocyte, Fatty Change, Focal      | 2  2  1  1     1  2  1  2  2           2        3  2  2  2  2  1  2     2|             
      Hepatocyte, Necrosis, Focal          |                         2                                                |             
      Hepatocyte, Vacuolization Cytoplasmic|             3                       2     3  1                 3     3   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +           +        +  +                    +        +        +     +   |             
      Inflammation, Chronic                |                                                                      2   |             
      Fat, Necrosis, Focal                 | 2                    3                       3        3        4     3   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 4| 3| 3| 3| 9| 3| 3| 3| 9| 0| 4| 0| 3| 3| 3| 3| 3| 5| 3| 1| 3|             
                                           | 0| 0| 4| 4| 2| 4| 4| 4| 4| 8| 5| 5| 3| 5| 2| 6| 0| 0| 0| 0| 0| 3| 4| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Oral Mucosa                             |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Acinus, Atrophy, Diffuse             |                                                                          |             
      Acinus, Atrophy, Focal               | 2        1  3  2  3  3        1           3  3  2        2        3     3|             
      Duct, Cyst, Focal, Multiple          | 1     2        2  2  3                    2           3     1  2         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     2                                    |             
      Ulcer                                |             3                             2                              |             
      Epithelium, Hyperplasia              |                                     2     2                              |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |       1                                                                  |             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Ulcer                                |                                     2                                    |             
      Epithelium, Hyperplasia              |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |    +                       +                                             |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        2     1  1  2     2  1  1     2     1  1  1  2  2  2     2  1   |             
      Thrombosis                           |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                 1                        |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 4| 3| 3| 3| 9| 3| 3| 3| 9| 0| 4| 0| 3| 3| 3| 3| 3| 5| 3| 1| 3|             
                                           | 0| 0| 4| 4| 2| 4| 4| 4| 4| 8| 5| 5| 3| 5| 2| 6| 0| 0| 0| 0| 0| 3| 4| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |          2           1  1  1        1  2  2        2     1        1  2  1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |             2        1        1                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |          X                    X  X           X                           |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hypertrophy, Focal    |                         3  1     1  1     2        1     3  2        1  1|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  2     1           1     2     1  2           1     1        1     1  1|             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Degeneration, Focal        |                1  2           2           1                              |             
      Follicle, Mineralization             | 1  1     1           1                          1                        |             
      Follicular Cell, Hyperplasia, Focal  |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                         +                       +                        |             
      Inflammation, Chronic, Focal         |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |             +                 +                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 4| 3| 3| 3| 9| 3| 3| 3| 9| 0| 4| 0| 3| 3| 3| 3| 3| 5| 3| 1| 3|             
                                           | 0| 0| 4| 4| 2| 4| 4| 4| 4| 8| 5| 5| 3| 5| 2| 6| 0| 0| 0| 0| 0| 3| 4| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Degeneration, Cystic                 |                                                       2                  |             
      Inflammation, Chronic                | 1     3                          2                 2     2     2         |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1     1  1  2     1        3        1     3     3  1     2        1  2  3|             
      Epithelium, Hyperplasia, Focal       |                   2  1  1           1                                    |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                    3                 3        3|             
      Interstitial Cell, Hyperplasia, Focal|             2                       2     2                       2  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3                    3                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +        +  +        +  +  +  +  +  +  +  +  +           +     +     +   |             
      Deep Cervical, Hyperplasia,          |                                                                          |             
          Histiocytic                      |                            3                                             |             
      Mediastinal, Hemorrhage              |          3                                                           3   |             
      Mediastinal, Hyperplasia, Histiocytic|                                                          3               |             
      Mediastinal, Hyperplasia, Plasma Cell|                                        3                                 |             
      Pancreatic, Hemorrhage               | 2                                                                    2   |             
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Fibrosis, Focal                      |                                                                3         |             
      Hematopoietic Cell Proliferation     |                            2                                             |             
      Hemorrhage                           |                                              3                           |             
      Inflammation, Granulomatous          |                            1                                             |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 4| 3| 3| 3| 9| 3| 3| 3| 9| 0| 4| 0| 3| 3| 3| 3| 3| 5| 3| 1| 3|             
                                           | 0| 0| 4| 4| 2| 4| 4| 4| 4| 8| 5| 5| 3| 5| 2| 6| 0| 0| 0| 0| 0| 3| 4| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  M  M  M  +  +  +  +  M  +|             
      Dilatation                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |             3                                                            |             
      Hyperkeratosis, Focal                |                                                                   2      |             
      Epidermis, Hyperplasia, Focal        |                                                                   1      |             
      Subcutaneous Tissue, Edema           |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                            +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                                                          |             
      Hemorrhage, Focal                    |             1                       3                                    |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |    +                                                                     |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                               2        3                                 |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic, Focal         |    1                                                                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |          1                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 4| 3| 3| 3| 9| 3| 3| 3| 9| 0| 4| 0| 3| 3| 3| 3| 3| 5| 3| 1| 3|             
                                           | 0| 0| 4| 4| 2| 4| 4| 4| 4| 8| 5| 5| 3| 5| 2| 6| 0| 0| 0| 0| 0| 3| 4| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1250 PPM                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Alveolus, Proteinosis                |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                         1                                                |             
      Inflammation, Suppurative            |       2                 2     2                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Nephropathy                          | 1  2     1  1  2  1  1  2  1  1  1  1  1  2     1  1  1  2  1  1  1  1  2|             
      Pelvis, Dilatation                   |                         2                                                |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                            2                                         4   |             
      Renal Tubule, Pigmentation           |                                           3                              |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Hyperplasia              |                                                                      3   |             
      Transitional Epithelium, Hyperplasia |                                                                      2   |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3|            |
                                           | 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1250 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Basophilic Focus                     |    X  X     X  X  X           X     X  X  X  X  X     X        X  X  X  X|     30     |
      Clear Cell Focus                     |    X  X  X  X  X  X           X     X  X  X  X  X     X        X  X  X   |     29     |
      Degeneration, Cystic, Focal          |                               2                                          |      1  2.0|
      Eosinophilic Focus                   |                                  X                                X      |      7     |
      Hepatodiaphragmatic Nodule           |                                                             X           X|      5     |
      Histiocytosis                        | 2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2|     50  1.9|
      Hyperplasia, Focal, Histiocytic      |                                     2                                    |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                           2                             1|      5  1.6|
      Inflammation, Chronic                |    1  1  1  2  1  1           2     1  1  1  2  1     1        1  1  1  1|     31  1.3|
      Mixed Cell Focus                     |          X        X                                   X                 X|     11     |
      Thrombosis                           |                                                                          |      1  3.0|
      Bile Duct, Dilatation, Focal         |                                                                      2   |      2  1.5|
      Bile Duct, Hyperplasia               | 4  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3     2  3  3  3  1|     49  2.9|
      Hepatocyte, Fatty Change, Focal      |    1  2  2  1  2  3  2        2  1  2  2  3  2  2     2        2  2  3  2|     37  1.9|
      Hepatocyte, Necrosis, Focal          |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                      2     3                       3     1  1           2|     12  2.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3|            |
                                           | 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1250 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               |                         +                                +  +            |  11        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                                                                          |      6  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                              +                           |   1        |
      Hyperplasia, Focal, Squamous         |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                           3                              |      1  3.0|
      Acinus, Atrophy, Diffuse             | 3                                                                        |      1  3.0|
      Acinus, Atrophy, Focal               |    2  1     1              3  2  1        1  2  1        2        3      |     24  2.1|
      Duct, Cyst, Focal, Multiple          |       2  1  1           2  2                 2                    2      |     16  1.9|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  2.5|
      Epithelium, Hyperplasia              |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                          |      1  1.0|
      Hyperplasia, Focal, Histiocytic      |                                              1                           |      1  1.0|
      Ulcer                                |                                                             3            |      2  2.5|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                   +      |   1        |
      Epithelium, Hyperplasia              |                                                                   1      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3|            |
                                           | 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1250 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Cardiomyopathy                       | 2  2  1  3     2  1  3  1     2  2  2  1  2  2  2     2     1  1     1   |     36  1.6|
      Thrombosis                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |             1  1              2                    1                     |      5  1.2|
      Cytoplasmic Alteration, Focal        |                                        2                                 |      1  2.0|
      Necrosis                             |                                                             2            |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |          1                                                               |     13  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  I  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |    2                                      3                 3        2   |      4  2.5|
      Cyst                                 |                            X                    X                        |      6     |
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                   1                 2                                    |      2  1.5|
      Pars Distalis, Hyperplasia, Focal    |                                     2                                    |      1  2.0|
      Pars Distalis, Hypertrophy, Focal    |    3              2                 2  2  3        1     2        3  1  1|     20  1.8|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  |       1        2  1           3  4  2     1  1  1     1     3  1  1     1|     26  1.5|
      Follicle, Cyst                       |                                        X                                 |      1     |
      Follicle, Degeneration, Focal        |       1                    1           1     1                           |      8  1.3|
      Follicle, Mineralization             |                                                                          |      5  1.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3|            |
                                           | 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1250 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |                                                 +                        |   3        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                            +                       +     +  +            |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                        2                                 |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                      3   |      2  2.5|
      Inflammation, Chronic                |    2  2        2        2  1     2  2  1  2  2  2  2  2  1     2         |     21  1.9|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    1  2  1  1  2     3        2  1     1  1           1        2     2  1|     28  1.6|
      Epithelium, Hyperplasia, Focal       |                                                          1               |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            3     3           3              3            |      8  3.0|
      Interstitial Cell, Hyperplasia, Focal|                                              1                           |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +        +  +     +     +        +           +     +     +  +           +|  26        |
      Deep Cervical, Hyperplasia,          |                                                                          |            |
          Histiocytic                      |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3|            |
                                           | 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1250 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Mediastinal, Hyperplasia, Histiocytic|                   3                                                      |      2  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|             3                                                            |      2  3.0|
      Pancreatic, Hemorrhage               | 3                                                                        |      3  2.3|
      Pancreatic, Hyperplasia, Histiocytic |                                                                         3|      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Accessory Spleen                     |                                  X                                       |      1     |
      Fibrosis, Focal                      |                                     3                                    |      2  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Angiectasis                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M|  41        |
      Dilatation                           |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                         2|      2  2.5|
      Hyperkeratosis, Focal                |                                                                          |      1  2.0|
      Epidermis, Hyperplasia, Focal        |                                                                          |      1  1.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3|            |
                                           | 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1250 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |          3                                                               |      1  3.0|
      Hemorrhage, Focal                    |                                                          3               |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                                                          2               |      3  2.3|
      Infiltration Cellular, Mixed Cell    |                                                                         2|      1  2.0|
      Inflammation, Chronic, Focal         |             1                                            2        1      |      4  1.3|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                            2                                      2      |      3  1.7|
      Alveolus, Proteinosis                |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                 1                        |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Lymphoid         |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3|            |
                                           | 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    1250 PPM                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Inflammation                         |          1                                                  3            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |             +                                                           +|   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infarct                              | 3                                                                        |      1  3.0|
      Nephropathy                          | 3  1  1  2  1  2  2     2  1  1  2  2  1  2  1  1  1  2  1  3  1  2  2  2|     47  1.4|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      2  3.0|
      Renal Tubule, Pigmentation           | 3                                                                        |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Muscularis, Hyperplasia              |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 6| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 8| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 0| 3| 3| 7| 3| 3| 3| 8|             
                                           | 2| 9| 4| 0| 4| 4| 0| 0| 0| 4| 4| 4| 4| 4| 2| 4| 9| 7| 4| 4| 0| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +|             
      Edema                                |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  A  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X     X  X  X  X  X  X  X  X     X        X     X  X     X  X  X   |             
      Clear Cell Focus                     |       X     X     X  X  X  X  X  X     X              X  X     X  X  X   |             
      Degeneration, Cystic, Focal          | 2     1        2           2              2                          3   |             
      Eosinophilic Focus                   |                         X     X        X                 X        X  X   |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Histiocytosis                        | 3  2  2  3  2  2  2  2  2  2  3  2  3  2  2  3  1  3  2  2  3  2  2  2  3|             
      Hyperplasia, Focal, Histiocytic      |                                                                          |             
      Infiltration Cellular, Mixed Cell    |       2     2     1              1     1              1        1     1   |             
      Inflammation, Chronic                |       2        2  1  1  2  1     1     1        1     2  1     1  1  2   |             
      Mixed Cell Focus                     |       X     X     X  X  X  X  X  X     X              X  X     X     X   |             
      Bile Duct, Dilatation, Focal         |                                                                          |             
      Bile Duct, Hyperplasia               | 3  3     3  3     3  3  3  3  3  3  3  3  3  3        3     3     3  3  3|             
      Hepatocyte, Fatty Change, Focal      |       1     3     3  3  3  2  3  3     2              2  2     3  2  2  2|             
      Hepatocyte, Vacuolization Cytoplasmic| 2  2     2     3                    2     2  2  3  2        4        2   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +     +                             +  +                 +  +            |             
      Inflammation, Chronic                |                                                                          |             
      Artery, Thrombosis                   |                                     3                                    |             
      Fat, Necrosis, Focal                 |       3                                3                 2  3            |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 6| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 8| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 0| 3| 3| 7| 3| 3| 3| 8|             
                                           | 2| 9| 4| 0| 4| 4| 0| 0| 0| 4| 4| 4| 4| 4| 2| 4| 9| 7| 4| 4| 0| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy, Focal               |       2  2     2     3  1  1  1     2        1              3        1   |             
      Duct, Cyst, Focal, Multiple          |                      2  2        2                    2        1         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Diverticulum                         |                                              2                           |             
      Inflammation                         |                            2                                             |             
      Ulcer                                |                                           3                 2            |             
      Epithelium, Hyperplasia              | 1                       2  2                                             |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Cyst                                 |                               2                                          |             
      Erosion                              |    1                                         3              1            |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                         +                                                |             
      Epithelium, Hyperplasia              |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |                         +                                                |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1  1  2  1  2  2  1  2  2        1  2     1  3  2  2        2  2  2|             
      Thrombosis                           |                                     2        4                          3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       1                 1  1        1                          1         |             
      Cytoplasmic Alteration, Focal        |                         1                                                |             
      Hyperplasia, Focal                   |             1                                                            |             
      Vacuolization Cytoplasmic, Focal     |                      2                                      2  1         |             
      Capsule, Hyperplasia, Focal          |                                              2                           |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 6| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 8| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 0| 3| 3| 7| 3| 3| 3| 8|             
                                           | 2| 9| 4| 0| 4| 4| 0| 0| 0| 4| 4| 4| 4| 4| 2| 4| 9| 7| 4| 4| 0| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             3                                                            |             
      Cyst                                 |                               X                                          |             
      Fibrosis, Focal                      |                               3                                          |             
      Hemorrhage                           |                               3                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hypertrophy, Focal    |          1     3     2  4        2        2           1           2  3   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  A|             
      C-Cell, Hyperplasia                  | 1  1  4     1  1  2  1  2        1  1  2              2  2     2  1  2   |             
      Follicle, Cyst                       |                   X                                                      |             
      Follicle, Degeneration, Focal        |                            2     1                                       |             
      Follicle, Mineralization             | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                           +        +                     |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                             3            |             
      Hemorrhage                           |                                                             3            |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Degeneration, Cystic                 |                3                                               2        3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 6| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 8| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 0| 3| 3| 7| 3| 3| 3| 8|             
                                           | 2| 9| 4| 0| 4| 4| 0| 0| 0| 4| 4| 4| 4| 4| 2| 4| 9| 7| 4| 4| 0| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Inflammation, Chronic                | 2  2     1  1        1     1     1        1  2     2     2        2  1   |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       1  1  2  2  3  2  2  2  2  3  2  1  2        2  2  3  2  1  2  3   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     3                 3  3     3                                      3|             
      Interstitial Cell, Hyperplasia, Focal|          2  1  1                                                        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +  +     +  +     +           +     +  +  +        +        +  +        +|             
      Mediastinal, Ectasia                 |                   3                    3                                 |             
      Mediastinal, Hemorrhage              |                                                                3         |             
      Mediastinal, Hyperplasia, Histiocytic|             3                                                            |             
      Mediastinal, Hyperplasia, Plasma Cell|                   3                                                      |             
      Pancreatic, Fibrosis                 | 3                                                                        |             
      Pancreatic, Hemorrhage               |                                     3                                    |             
      Pancreatic, Hyperplasia, Histiocytic |                                     3  3                                 |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     3                                    |             
      Hyperplasia, Histiocytic             |                                        3                                 |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                               X                          X               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                           3                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 6| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 8| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 0| 3| 3| 7| 3| 3| 3| 8|             
                                           | 2| 9| 4| 0| 4| 4| 0| 0| 0| 4| 4| 4| 4| 4| 2| 4| 9| 7| 4| 4| 0| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Inflammation, Granulomatous          |                         3  1                                             |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M|             
      Dilatation                           |                                                                4         |             
      Fibrosis                             |                                                             3            |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Focal                  |                         1                                                |             
      Subcutaneous Tissue, Fibrosis, Focal |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                                                          |             
      Hemorrhage, Focal                    |                                           3        3                     |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |    +           +                                                         |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |    +           +                                                         |             
      Hemorrhage, Focal                    |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                                                                     |             
      Infiltration Cellular, Mixed Cell    |                2                                2                        |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Focal                  |                                              1                           |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 6| 7| 7| 6| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 8| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 0| 3| 3| 7| 3| 3| 3| 8|             
                                           | 2| 9| 4| 0| 4| 4| 0| 0| 0| 4| 4| 4| 4| 4| 2| 4| 9| 7| 4| 4| 0| 4| 4| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    2500 PPM                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             2                                                            |             
      Inflammation, Suppurative            |             3                                         1                  |             
      Nasolacrimal Duct, Inflammation      |             2     2              1                                       |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +|             
      Cataract                             |                                                                          |             
      Anterior Chamber, Exudate            |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              | 3                                            2                           |             
      Nephropathy                          | 3  2  1  1  2  1  2  2  2  1  2  1  2  2  2  2  1     2  2     1  2  1   |             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                              2                           |             
                                           |__________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Muscularis, Inflammation, Chronic    |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3|            |
                                           | 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2500 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Edema                                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  44        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X     X  X  X  X  X  X  X  X     X  X  X     X  X  X  X        X|     36     |
      Clear Cell Focus                     | X  X  X           X  X  X  X  X     X     X  X  X  X     X  X  X        X|     31     |
      Degeneration, Cystic, Focal          | 2                                                                        |      7  2.0|
      Eosinophilic Focus                   |                            X  X           X  X           X              X|     12     |
      Hepatodiaphragmatic Nodule           |                               X           X     X        X               |      4     |
      Histiocytosis                        | 2  2  2  3  2  3  2  2  3  2  2  2  2  2  2  2  3  2  3  2  2  2  3  2  2|     50  2.3|
      Hyperplasia, Focal, Histiocytic      | 2                 2                             2                        |      3  2.0|
      Infiltration Cellular, Mixed Cell    | 1                          1                    1  1  1  1  1  1        1|     17  1.1|
      Inflammation, Chronic                | 2  1  3  1        1  1  2  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1|     36  1.3|
      Mixed Cell Focus                     |       X  X           X  X  X  X  X  X     X  X  X        X  X  X         |     27     |
      Bile Duct, Dilatation, Focal         |                      2  1                                                |      2  1.5|
      Bile Duct, Hyperplasia               | 3  3  3  3     2     3  3  3  3  2  3  3  3  3  3  3  3  3  3  3  3  3  3|     42  3.0|
      Hepatocyte, Fatty Change, Focal      | 3  2  1  2        2  3  3  3  2     3     2  3  3  3     3  3  3        3|     33  2.5|
      Hepatocyte, Vacuolization Cytoplasmic|             3  2                 1     2  3           2           3      |     18  2.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |             +                 +        +              +                  |  10        |
      Inflammation, Chronic                |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3|            |
                                           | 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2500 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Artery, Thrombosis                   |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                               3                                          |      5  2.8|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                3                                                         |      1  3.0|
      Acinus, Atrophy, Focal               |    2  1     3           1  2  2           3  1  1  1     3  3     4     1|     25  1.9|
      Duct, Cyst, Focal, Multiple          |                                           3              2  2  2  1      |     10  1.9|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Diverticulum                         |                                                                          |      1  2.0|
      Inflammation                         |                1                                      3                  |      3  2.0|
      Ulcer                                |                                                                   2      |      3  2.3|
      Epithelium, Hyperplasia              |                                                                   2      |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  2.0|
      Erosion                              |                2                                                  2  2   |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  1  1  2  2  2  2  2     2  2  2  1  3  3  2  2     1  1        2  1|     39  1.8|
      Thrombosis                           |                                                                   2      |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3|            |
                                           | 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2500 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Accessory Adrenal Cortical Nodule    |          1                 1                 1                          1|      9  1.0|
      Cytoplasmic Alteration, Focal        |                                  1                                       |      2  1.0|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Focal     |          1  1        1        1                                          |      7  1.3|
      Capsule, Hyperplasia, Focal          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                           3     2                        |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |       2                                                                  |      1  2.0|
      Pars Distalis, Hypertrophy, Focal    |                      2  2  2  3     1  2  2  2     2  1        2  2     2|     22  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  44        |
      C-Cell, Hyperplasia                  |    2  2           1  2  2     2  1  1        1  2           1  3        2|     29  1.7|
      Follicle, Cyst                       |                      X              X           X           X            |      5     |
      Follicle, Degeneration, Focal        |                                        1                          1      |      4  1.3|
      Follicle, Mineralization             |                         1              1           1     1  1            |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              |             +                                                            |   1        |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                    +  +              +   |   5        |
      Inflammation, Chronic                |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3|            |
                                           | 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2500 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                +                                                         |   1        |
      Inflammation, Chronic                |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                                                                          |      3  2.7|
      Inflammation, Chronic                | 2     2     2  2  2           2                       2        2  1     2|     23  1.7|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |    3  2  2  4  3  1           2  2  2           1  1     1  3  2  2     1|     36  2.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          3              3           3                    4               |     10  3.1|
      Interstitial Cell, Hyperplasia, Focal|       2     2                          1                                 |      7  1.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  3                                                  3                  |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +     +  +  +  +     +              +  +        +  +  +        +  +  +|  27        |
      Mediastinal, Ectasia                 |                                                          3               |      3  3.0|
      Mediastinal, Hemorrhage              |                3        3                                                |      3  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                          3              3|      3  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
      Pancreatic, Fibrosis                 |                                                                          |      1  3.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3|            |
                                           | 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2500 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Pancreatic, Hyperplasia, Histiocytic |    3                                      3                              |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M|   2        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |                                  3                                       |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Spleen                     |          X                                                               |      3     |
      Hematopoietic Cell Proliferation     |    2                                                                     |      1  2.0|
      Hyperplasia, Lymphoid                |                                           3                              |      1  3.0|
      Infarct                              |                                                                   3      |      2  3.0|
      Inflammation, Granulomatous          |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  I  +  +  +  +  +  +|  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  45        |
      Dilatation                           |                                                       2                  |      2  3.0|
      Fibrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                         3|      1  3.0|
      Inflammation, Focal                  |                                                                          |      1  1.0|
      Subcutaneous Tissue, Fibrosis, Focal |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3|            |
                                           | 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2500 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |          2                                                               |      1  2.0|
      Hemorrhage, Focal                    |                                                                      1   |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |             +                                                            |   3        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |             +                                                            |   3        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                3                                                         |      2  3.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      2  2.0|
      Inflammation, Chronic, Focal         |                1                                   1                     |      2  1.0|
      Inflammation, Focal                  |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Nasolacrimal Duct, Inflammation      |                                                       3                  |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  45        |
      Cataract                             |             2                 2                                          |      2  2.0|
      Anterior Chamber, Exudate            |             3                                                            |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                    3                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 92013-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                         4-METHYLIMIDAZOLE                                     Date: 12/06/04    
Route: DOSED FEED                                                                                                 Time: 08:41:26    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3|            |
                                           | 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    2500 PPM                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                                   2  2   |      4  2.3|
      Nephropathy                          | 2  2  2  2  1  1  1  2  2  2  1  1  1  3  2  2  2  1  3  2  2  2  1     1|     46  1.7|
      Pelvis, Dilatation                   |                3                                                         |      1  3.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                   2      |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Urethra                                 |                +                                                         |   1        |
      Muscularis, Inflammation, Chronic    |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                4                                                         |      1  4.0|
      Inflammation                         |                3                                                         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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