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TDMS Study 93020-05 Pathology Tables

NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97
Route: SKIN APPLICATION                                                                                           Time: 14:05:56

                                                       150 DAY SUBCHRONIC




       Facility:  Microbiological Associates

       Chemical CAS #:  693-13-0

       Lock Date:  03/26/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 0| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 9| 4| 4| 1| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 7| 1| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  A  +  M  +  +  M  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +                                             |   9        |
      Ulcer, Chronic Active                |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |             3                                                            |      1  3.0|
      Inflammation, Focal                  | 1  1        3     2  1  2  2                                             |      7  1.7|
      Necrosis                             |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +  +  +  +  +  +  +                                             |   9        |
      Inflammation, Focal                  |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +     +     +                                                   |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Aorta, Adventitia, Inflammation,     |                                                                          |            |
           Focal                           | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  M  M  M  M  +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  I  +  +  M  +  +  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  M  +  +  M  +  +  +                                             |   7        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   2                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 0| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 9| 4| 4| 1| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 7| 1| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hydrometra                           |          1                                                               |      1  1.0|
      Bilateral, Hydrometra                |             1     2                                                      |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Myeloid Cell, Hyperplasia            |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Plasma Cell   |                3                                                         |      1  3.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +                                             |   9        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |             3                                                            |      1  3.0|
      Infiltration Cellular, Histiocyte    |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  A  +  +  +  +  +  +  +                                             |   9        |
      Hematopoietic Cell Proliferation     | 2  3     3  3     2  2     2                                             |      7  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +                                             |   9        |
      Atrophy                              |             3                                                            |      1  3.0|
      Thymocyte, Necrosis                  |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic, Focal         |                   2                                                      |      1  2.0|
      Inflammation, Focal                  | 2           1                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         | 2                 2                                                      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   3                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 0| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 9| 4| 4| 1| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 7| 1| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   4                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 0| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 4| 4| 3| 4|                                            |            |
                                           | 1| 1| 1| 3| 1| 1| 1| 1| 8| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    4.38                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +        +  +                                                |   6        |
      Inflammation, Focal                  | 2  1        1        1                                                   |      4  1.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +  +  +           +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +        +           +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          M              M                                                |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          +              +                                                |   2        |
      Atrophy                              |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +              +                                                |   2        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   5                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 0| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 4| 4| 3| 4|                                            |            |
                                           | 1| 1| 1| 3| 1| 1| 1| 1| 8| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    4.38                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +              +                                                |   2        |
      Pigmentation                         |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +           +  +                                             |   5        |
      Hematopoietic Cell Proliferation     |       3  2  2           2  1                                             |      5  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +              +                                                |   2        |
      Atrophy                              |          3              4                                                |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +           +  +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +              +  +                                             |   5        |
      Inflammation                         | 3  3                       1                                             |      3  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +              +                                                |   2        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   6                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 0| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 3| 9| 4| 4| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 3| 9| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    8.75                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +                                                   |   7        |
      Hematopoietic Cell Proliferation     |             2                                                            |      1  2.0|
      Inflammation, Focal                  |       2  1        1                                                      |      3  1.3|
      Inflammation                         | 1                                                                        |      1  1.0|
      Necrosis                             |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +                 +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +  +  M        +     +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +                                                            |   3        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       M  M                                                               |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  M                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +  M                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   7                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 0| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 3| 9| 4| 4| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 3| 9| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    8.75                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +                                                               |   2        |
      Myeloid Cell, Hyperplasia            |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |   1        |
      Infiltration Cellular, Plasma Cell   |                3                                                         |      1  3.0|
      Infiltration Cellular, Histiocyte    |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +                                                               |   2        |
      Infiltration Cellular, Plasma Cell   |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +                                                               |   2        |
      Infiltration Cellular, Histiocyte    |          2                                                               |      1  2.0|
      Inflammation, Focal                  |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +     +                                                         |   3        |
      Hematopoietic Cell Proliferation     |       3        3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +                                                               |   2        |
      Atrophy                              |       4                                                                  |      1  4.0|
      Thymocyte, Necrosis                  |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +     +           +                                             |   4        |
      Dermis, Atrophy                      |                2                                                         |      1  2.0|
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Inflammation                    |                3                                                         |      1  3.0|
      Epidermis, Hyperplasia               |                2                                                         |      1  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |                2                                                         |      1  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Inflammation                    |                2           1                                             |      2  1.5|
      Skin, Site of Application, Ulcer,    |                                                                          |            |
           Chronic Active                  |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +                                                               |   2        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   8                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 0| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 3| 9| 4| 4| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 3| 9| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    8.75                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Focal                  |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  M                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +                                                               |   2        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   9                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 8| 4| 4| 4| 4| 0|                                            |            |
                                           | 1| 1| 1| 1| 2| 1| 1| 1| 1| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    17.5                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +     +  A  +  +  +  +  +                                             |   7        |
      Inflammation, Focal                  |    1     1     1  1  1  1  2                                             |      7  1.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +              +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +        +  +     +     +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |             +     +        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +              M                                             |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |             I              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |             M              +                                             |   1        |
      Atrophy                              |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +              +                                             |   2        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  10                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 8| 4| 4| 4| 4| 0|                                            |            |
                                           | 1| 1| 1| 1| 2| 1| 1| 1| 1| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    17.5                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   1        |
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +              M                                             |   1        |
      Infiltration Cellular, Plasma Cell   |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  A              +                                             |   3        |
      Fibrosis                             | 2                                                                        |      1  2.0|
      Hematopoietic Cell Proliferation     | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |             M              M                                             |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +  +              +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +           +              +                                             |   3        |
      Inflammation, Chronic Active, Focal  | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +              +                                             |   2        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  11                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 0| 0| 1| 0| 1| 1| 1| 0|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 6| 4| 4| 4| 5|                                            |            |
                                           | 1| 1| 8| 5| 1| 6| 1| 1| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    35                                     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +     M           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +  M     +           M                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +  +     +     +  +  +                                             |   6        |
      Inflammation, Focal                  |                      2  2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |          +                                                               |   1        |
      Epithelium, Hyperkeratosis           |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +        +     +                                                      |   3        |
      Hyperplasia, Odontogenic             |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +     +  +        +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       M  M     M           M                                             |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  M     +           M                                             |   2        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +  M     +           M                                             |   2        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +     +           +                                             |   4        |
      Bilateral, Hydrometra                |                1                                                         |      1  1.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  12                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 0| 0| 1| 0| 1| 1| 1| 0|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 6| 4| 4| 4| 5|                                            |            |
                                           | 1| 1| 8| 5| 1| 6| 1| 1| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    35                                     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +     +        +  A                                             |   4        |
      Inflammation, Focal                  |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  A     +     +  +  +                                             |   6        |
      Hematopoietic Cell Proliferation     |    3  2        2     3  2                                                |      5  2.4|
      Lymphoid Follicle, Necrosis          |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +     +           A                                             |   3        |
      Thymocyte, Necrosis                  |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       M  +     +           M                                             |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +     +           +                                             |   4        |
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Inflammation                    |                2                                                         |      1  2.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Hyperplasia                     |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +     +           +                                             |   4        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  13                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    70                                     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  I  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |    1                                                                     |      1  1.0|
      Inflammation, Focal                  | 2     2  1  1  2     2  2  2                                             |      8  1.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +        +  +  +  +  +     +                                             |   7        |
      Hyperplasia, Odontogenic             | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  +  +  M  M  +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  M  +  +  +  +  M  M                                             |   6        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  M                                             |   8        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hydrometra                           |                      2     2                                             |      2  2.0|
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  14                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    70                                     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Hydrometra                |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 2  3  3  3  2  2  2  2  1                                                |      9  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Inflammation                    |          1                                                               |      1  1.0|
      Epidermis, Skin, Site of Application,|                                                                          |            |
           Inflammation, Chronic Active    |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active, Focal  |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         |                   3        3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  15                                                               
NTP Experiment-Test: 93020-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    70                                     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page  16                                                               
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------