TDMS Study 88004-05 Pathology Tables
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
FINAL #1 RATS
Facility: Battelle Northwest
Chemical CAS #: 1321-74-0
Lock Date: 04/16/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 10 16 14 26
Natural Death 7 3 3 2
Accidently Killed 1
Survivors
Terminal Sacrifice 33 30 33 22
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (49) (49) (50)
Epithelium, Metaplasia, Focal, Squamous 1 [3.0]
Liver (50) (50) (50) (50)
Clear Cell Focus 5 [2.0] 7 [2.4] 6 [2.8]
Hepatodiaphragmatic Nodule 5 [4.0] 7 [4.0] 6 [3.5] 9 [4.0]
Necrosis 1 [3.0]
Vacuolization Cytoplasmic 4 [2.0] 3 [3.0] 3 [2.0]
Bile Duct, Hyperplasia 1 [4.0]
Hepatocyte, Regeneration 1 [4.0] 1 [4.0]
Periportal, Inflammation, Chronic 3 [2.3] 2 [3.0] 1 [2.0] 2 [1.5]
Portal, Bile Stasis 1 [3.0] 3 [3.7] 2 [3.5] 1 [3.0]
Serosa, Fibrosis 1 [3.0]
Mesentery (15) (20) (17) (6)
Necrosis 14 [3.0] 20 [3.0] 16 [3.1] 6 [3.0]
Oral Mucosa (1)
Pharyngeal, Ulcer 1 [4.0]
Pancreas (50) (49) (50) (50)
Acinus, Atrophy 3 [1.7] 5 [1.2] 2 [1.0] 4 [2.8]
Salivary Glands (50) (50) (50) (50)
Inflammation, Chronic 1 [3.0]
Stomach, Forestomach (50) (50) (49) (49)
Hyperplasia, Focal, Squamous 1 [4.0] 1 [3.0]
Ulcer 1 [4.0] 1 [3.0] 1 [4.0] 1 [4.0]
Stomach, Glandular (50) (50) (49) (49)
Erosion 1 [2.0] 1 [2.0]
Ulcer 1 [4.0]
Epithelium, Hyperplasia 1 [2.0]
Tongue (1) (1) (3) (3)
Epithelium, Hyperplasia 1 [4.0] 3 [2.7] 2 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Tooth (1)
Peridontal Tissue, Inflammation 1 [4.0]
Pulp, Inflammation, Suppurative 1 [4.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 3 [1.7]
Atrium, Thrombosis 1 [4.0] 2 [4.0]
Pericardium, Infiltration Cellular, Lymphoid 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 [4.0]
Hemorrhage 1 [2.0]
Hyperplasia 1 [2.0]
Necrosis 1 [4.0]
Vacuolization Cytoplasmic 14 [1.9] 5 [1.8] 7 [1.6] 12 [1.5]
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 1 [2.0] 1 [2.0] 5 [2.6] 2 [3.0]
Parathyroid Gland (49) (49) (47) (49)
Hyperplasia 1 [2.0]
Pituitary Gland (50) (50) (50) (50)
Cyst 6 [3.5] 6 [2.8] 1 [4.0] 5 [2.8]
Pars Distalis, Angiectasis 1 [3.0]
Pars Distalis, Hematocyst 1 [4.0]
Pars Distalis, Hyperplasia 4 [3.0] 8 [2.9] 4 [3.0] 7 [2.3]
Thyroid Gland (50) (50) (50) (50)
Ultimobranchial Cyst 1 [2.0]
C-Cell, Hyperplasia 5 [2.8] 8 [2.0] 6 [1.8] 1 [1.0]
Follicular Cell, Hyperplasia 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Clitoral Gland (50) (50) (50) (50)
Cyst 3 [3.7] 1 [4.0]
Hyperplasia 1 [3.0] 3 [4.0] 2 [2.5] 2 [4.0]
Inflammation, Chronic 2 [3.5] 1 [2.0] 1 [3.0]
Ovary (50) (50) (50) (50)
Cyst 5 [3.6] 6 [2.7] 11 [3.2] 4 [2.8]
Bilateral, Cyst 1 [3.0]
Uterus (50) (50) (50) (50)
Hemorrhage 1 [4.0]
Necrosis 1 [4.0]
Endometrium, Hyperplasia 2 [2.5] 1 [2.0] 1 [3.0] 2 [1.5]
Myometrium, Hyperplasia 1 [3.0]
Vagina (2) (3)
Inflammation, Suppurative 1 [4.0]
Muscularis, Hypertrophy 1 [4.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Myelofibrosis 1 [3.0]
Lymph Node (6) (10) (9) (8)
Deep Cervical, Infiltration Cellular,
Histiocyte 3 [3.3] 1 [2.0]
Pancreatic, Pigmentation 1 [4.0] 1 [4.0]
Lymph Node, Bronchial (8) (9) (5) (14)
Infiltration Cellular, Histiocyte 1 [3.0]
Lymph Node, Mesenteric (50) (50) (50) (50)
Infiltration Cellular, Histiocyte 2 [2.5] 1 [3.0] 2 [3.5]
Pigmentation 1 [4.0]
Lymph Node, Mediastinal (32) (37) (44) (34)
Fibrosis 1 [3.0]
Hyperplasia, Lymphoid 1 [4.0] 1 [3.0]
Infiltration Cellular, Histiocyte 2 [3.0] 1 [3.0]
Inflammation, Suppurative 1 [3.0]
Spleen (50) (50) (50) (50)
Accessory Spleen 2 1 1
Fibrosis 3 [3.0] 1 [4.0] 3 [3.3] 1 [2.0]
Hematopoietic Cell Proliferation 1 [4.0]
Hemorrhage 2 [3.5] 1 [4.0] 1 [4.0] 2 [4.0]
Hyperplasia, Focal, Lymphoid 2 [3.5]
Inflammation, Chronic Active 1 [3.0]
Necrosis 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymus (45) (41) (46) (39)
Cyst 1 [4.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 1 [1.0] 2 [2.0]
Hyperplasia 1 [3.0]
Inflammation, Chronic 1 [3.0]
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 2 [4.0] 1 [4.0]
Hyperkeratosis 1 [3.0]
Inflammation, Granulomatous 1 [4.0]
Ulcer 1 [4.0] 1 [4.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Joint, Fracture 1 [4.0]
Tibia, Fracture 1 [4.0]
Skeletal Muscle (2) (3) (7) (5)
Inflammation, Chronic 1 [4.0]
Necrosis 1 [4.0] 1 [3.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 9 [3.1] 10 [3.1] 11 [2.9] 7 [3.1]
Congestion 1 [1.0]
Hemorrhage 2 [1.0] 2 [4.0] 6 [2.8] 3 [3.7]
Infarct 1 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (49) (50)
Foreign Body 1 [4.0] 3 [4.0]
Inflammation, Suppurative 2 [2.0] 1 [2.0]
Epiglottis, Metaplasia, Squamous 1 [2.0]
Lung (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Atrophy 1 [4.0]
Cyst 1 [4.0]
Foreign Body 1 [2.0]
Hemorrhage 1 [2.0] 1 [1.0] 1 [2.0] 1 [3.0]
Infiltration Cellular, Histiocyte 1 [4.0]
Inflammation, Chronic 1 [2.0]
Inflammation, Chronic, Diffuse 1 [3.0] 1 [2.0]
Inflammation, Chronic, Focal 27 [1.3] 22 [1.4] 26 [1.3] 33 [1.2]
Alveolar Epithelium, Hyperplasia 4 [2.3] 2 [1.5] 3 [1.7] 1 [3.0]
Alveolar Epithelium, Hypertrophy 1 [1.0] 1 [1.0] 1 [2.0]
Alveolus, Infiltration Cellular, Focal,
Histiocyte 8 [1.1] 3 [1.3] 6 [1.3] 5 [1.2]
Interstitium, Fibrosis 1 [1.0]
Mediastinum, Necrosis, Fatty 1 [4.0]
Nose (50) (50) (49) (49)
Foreign Body 1 [3.0] 5 [2.0] 1 [3.0]
Inflammation, Suppurative 5 [2.4] 12 [1.7] 8 [1.3] 7 [1.6]
Ulcer 1 [4.0]
Glands, Dilatation 17 [1.3] 38 [1.3] 44 [1.7]
Goblet Cell, Hyperplasia 1 [2.0] 3 [1.7] 1 [1.0] 4 [1.5]
Nasolacrimal Duct, Inflammation, Suppurative 3 [2.0] 1 [3.0] 3 [2.3] 1 [2.0]
Nasopharyngeal Duct, Inflammation,
Suppurative 1 [3.0]
Olfactory Epithelium, Degeneration 50 [1.5] 49 [1.8] 48 [2.0]
Olfactory Epithelium, Degeneration, Hyaline 10 [1.5] 14 [1.1] 15 [1.1] 4 [1.0]
Olfactory Epithelium, Hyperplasia, Basal Cell 25 [1.0] 42 [1.3] 45 [1.8]
Olfactory Epithelium, Regeneration, Focal 1 [1.0]
Respiratory Epithelium, Degeneration, Hyaline 5 [1.8] 3 [2.0] 4 [1.3]
Respiratory Epithelium, Hyperplasia 1 [2.0] 1 [3.0]
Respiratory Epithelium, Metaplasia, Squamous 1 [2.0]
Pleura (50) (50) (50) (49)
Fibrosis 1 [2.0]
Infiltration Cellular, Lymphoid 1 [4.0]
Trachea (50) (50) (50) (50)
Glands, Degeneration, Cystic 1 [1.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (48) (49) (49)
Atrophy 1 [4.0]
Inflammation, Chronic 1 [1.0]
Anterior Chamber, Hemorrhage 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Ciliary Body, Inflammation 1 [2.0]
Cornea, Inflammation 1 [2.0]
Lens, Cataract 1 [4.0] 3 [2.7] 4 [3.8] 1 [4.0]
Harderian Gland (50) (50) (50) (50)
Inflammation, Suppurative 1 [4.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Cyst 1 [4.0]
Nephropathy, Chronic 19 [1.4] 21 [1.3] 19 [1.7] 10 [2.2]
Bilateral, Cortex, Renal Tubule, Degeneration 1 [4.0]
Cortex, Infarct 2 [2.0]
Cortex, Renal Tubule, Accumulation, Hyaline
Droplet 1 [4.0]
Cortex, Renal Tubule, Hyperplasia 1 [3.0] 1 [1.0]
Medulla, Renal Tubule, Degeneration 1 [3.0]
Pelvis, Transitional Epithelium, Hyperplasia 1 [2.0] 1 [2.0]
Pelvis, Transitional Epithelium,
Mineralization 1 [2.0]
Renal Tubule, Dilatation 1 [4.0]
Urinary Bladder (50) (50) (49) (49)
Transitional Epithelium, Hyperplasia 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 15 9 12 13
Natural Death 4 6 6 5
Survivors
Terminal Sacrifice 31 35 31 32
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Foreign Body 1
Intestine Small, Jejunum (46) (47) (47) (46)
Necrosis 1 [3.0]
Intestine Small, Ileum (46) (47) (45) (46)
Dilatation 1 [4.0]
Liver (50) (49) (50) (50)
Angiectasis 1 [4.0] 1 [3.0]
Clear Cell Focus 2 [1.0] 5 [2.5] 1 [4.0] 1 [4.0]
Hemorrhage 1 [3.0]
Hepatodiaphragmatic Nodule 2 [4.0] 2 [4.0] 4 [4.0] 8 [4.0]
Inflammation, Granulomatous 1 [3.0]
Necrosis 1 [4.0] 1 [2.0] 3 [2.3] 2 [3.5]
Vacuolization Cytoplasmic 1 [3.0] 2 [2.0] 3 [2.7] 3 [2.3]
Bile Duct, Hyperplasia 3 [2.0]
Hepatocyte, Regeneration 1 [4.0]
Periportal, Inflammation, Chronic 2 [2.0]
Serosa, Fibrosis 1 [4.0] 1 [4.0]
Serosa, Hemorrhage 1 [4.0]
Mesentery (12) (13) (18) (11)
Necrosis 7 [2.9] 13 [2.9] 18 [2.9] 9 [3.0]
Fat, Hemorrhage 1 [4.0]
Oral Mucosa (1) (1) (4)
Gingival, Cyst 1 [4.0]
Gingival, Hyperplasia, Squamous 1 [1.0]
Pancreas (50) (49) (50) (50)
Thrombosis 1 [4.0]
Acinus, Atrophy 15 [1.8] 18 [1.8] 27 [1.7] 21 [2.0]
Acinus, Hyperplasia 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Inflammation 1 [2.0]
Duct, Cyst 1 [1.0] 2 [2.5] 3 [3.0]
Stomach, Forestomach (50) (48) (50) (50)
Diverticulum 1 [3.0]
Hyperplasia, Squamous 1 [2.0]
Inflammation, Suppurative 1 [1.0]
Ulcer 4 [3.0] 1 [4.0] 1 [4.0]
Stomach, Glandular (50) (48) (50) (49)
Erosion 2 [2.5] 2 [2.5] 2 [2.5]
Ulcer 1 [4.0] 2 [4.0] 1 [3.0]
Epithelium, Hyperplasia 1 [2.0]
Tongue (1) (1)
Epithelium, Hyperplasia 1 [3.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Thrombosis 1 [3.0]
Heart (50) (50) (50) (50)
Cardiomyopathy 7 [1.6] 5 [2.2] 1 [2.0] 1 [2.0]
Atrium, Thrombosis 2 [3.5] 1 [4.0] 2 [4.0] 1 [4.0]
Pericardium, Inflammation 1 [3.0]
Pericardium, Pigmentation 1 [4.0]
Pericardium, Epicardium, Infiltration
Cellular, Histiocyte 1 [4.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hyperplasia 1 [3.0] 2 [1.5]
Necrosis 2 [2.5]
Vacuolization Cytoplasmic 8 [2.1] 8 [1.8] 7 [1.7] 6 [1.8]
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 12 [3.2] 13 [2.7] 8 [2.4] 14 [2.3]
Bilateral, Hyperplasia 1 [4.0]
Islets, Pancreatic (50) (48) (50) (50)
Hyperplasia 1 [1.0] 1 [1.0] 2 [2.0] 2 [3.0]
Parathyroid Gland (46) (48) (49) (47)
Hyperplasia 1 [2.0] 1 [3.0]
Pituitary Gland (50) (50) (50) (49)
Cyst 1 [2.0] 1 [4.0] 1 [4.0] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hemorrhage 1 [3.0] 1 [3.0]
Pars Distalis, Hematocyst 1 [4.0]
Pars Distalis, Hyperplasia 5 [2.2] 8 [2.3] 9 [2.6] 8 [2.8]
Thyroid Gland (50) (50) (50) (49)
C-Cell, Hyperplasia 2 [2.5] 4 [3.0] 9 [2.6] 7 [2.4]
Follicular Cell, Hyperplasia 2 [2.0] 2 [2.5] 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Penis (2)
Inflammation 1 [4.0]
Preputial Gland (48) (50) (50) (49)
Cyst 1 [3.0] 1 [4.0] 2 [4.0] 1 [4.0]
Hyperplasia 1 [4.0] 4 [3.8] 1 [4.0] 1 [4.0]
Prostate (50) (50) (50) (50)
Hyperplasia 1 [1.0]
Inflammation, Suppurative 5 [2.0] 1 [2.0] 4 [3.5] 2 [1.5]
Seminal Vesicle (50) (49) (50) (50)
Dilatation 1 [4.0]
Hyperplasia 1 [3.0]
Inflammation, Suppurative 1 [3.0]
Testes (50) (50) (50) (50)
Artery, Inflammation, Chronic Active 2 [3.0]
Germinal Epithelium, Atrophy 16 [3.9] 12 [3.1] 11 [3.3] 9 [3.4]
Interstitial Cell, Hyperplasia 7 [3.0] 6 [2.8] 2 [2.5] 3 [2.7]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (11) (5) (11) (6)
Deep Cervical, Angiectasis 1 [4.0] 1 [2.0]
Deep Cervical, Cyst 1 [2.0]
Deep Cervical, Hemorrhage 1 [3.0]
Deep Cervical, Hyperplasia, Lymphoid 1 [3.0]
Pancreatic, Ectasia 1 [3.0]
Pancreatic, Hemorrhage 1 [3.0]
Pancreatic, Infiltration Cellular, Histiocyte 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Bronchial (7) (6) (12) (5)
Hemorrhage 1 [3.0]
Infiltration Cellular 1 [3.0]
Pigmentation 1 [3.0]
Lymph Node, Mesenteric (49) (49) (50) (50)
Angiectasis 1 [4.0]
Ectasia 1 [4.0]
Hemorrhage 1 [3.0]
Hyperplasia, Lymphoid 1 [4.0]
Infiltration Cellular, Histiocyte 1 [1.0] 1 [4.0] 3 [3.3]
Lymph Node, Mediastinal (19) (23) (25) (38)
Angiectasis 1 [4.0]
Hyperplasia, Lymphoid 1 [3.0]
Spleen (50) (49) (50) (50)
Accessory Spleen 3 1
Fibrosis 2 [3.5] 6 [3.2] 4 [3.3] 1 [4.0]
Hematopoietic Cell Proliferation 1 [4.0]
Hemorrhage 2 [4.0] 1 [4.0] 1 [4.0]
Hyperplasia, Focal, Lymphoid 1 [3.0]
Necrosis 3 [4.0] 1 [4.0] 1 [4.0] 1 [4.0]
Lymphocyte, Hyperplasia, Diffuse 1 [2.0]
Thymus (48) (44) (46) (42)
Hemorrhage 1 [3.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (35) (43) (47) (48)
Galactocele 3 [3.7] 2 [1.5] 6 [4.0] 3 [4.0]
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 4 [4.0] 1 [4.0] 3 [4.0] 2 [4.0]
Hyperkeratosis 2 [3.5] 1 [3.0] 2 [3.5]
Inflammation, Acute 2 [4.0]
Inflammation, Granulomatous 1 [4.0]
Ulcer 2 [3.5]
Subcutaneous Tissue, Thrombosis 1 [4.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 1 [3.0]
Cartilage, Femur, Hyperplasia 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Femur, Fracture 1 [4.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Compression 10 [2.9] 5 [2.4] 8 [2.9] 6 [3.5]
Gliosis 1 [3.0]
Hemorrhage 1 [4.0] 1 [3.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (49) (50) (49)
Foreign Body 1 [4.0] 2 [4.0] 3 [4.0] 2 [2.5]
Inflammation, Suppurative 1 [2.0] 1 [4.0] 1 [1.0]
Epiglottis, Metaplasia, Squamous 1 [3.0] 1 [2.0]
Lung (50) (50) (50) (50)
Congestion 1 [2.0]
Hemorrhage 2 [3.0] 1 [2.0] 4 [1.8] 4 [1.5]
Inflammation, Chronic 1 [3.0]
Inflammation, Chronic, Diffuse 1 [2.0]
Inflammation, Chronic, Focal 4 [1.0] 4 [1.5] 5 [1.6] 14 [1.1]
Inflammation, Suppurative 1 [1.0]
Necrosis 1 [2.0] 1 [4.0]
Thrombosis 1 [4.0]
Alveolar Epithelium, Hyperplasia 4 [2.5] 8 [1.8] 6 [1.7] 6 [3.2]
Alveolar Epithelium, Hypertrophy 1 [1.0] 1 [1.0] 2 [1.0]
Alveolus, Hypertrophy 1 [1.0]
Alveolus, Infiltration Cellular, Focal,
Histiocyte 9 [1.6] 12 [1.6] 11 [1.5] 4 [1.5]
Interstitium, Fibrosis 1 [2.0] 1 [1.0] 1 [1.0] 1 [1.0]
Mediastinum, Abscess 1 [3.0]
Mediastinum, Inflammation, Chronic 1 [2.0]
Mediastinum, Pigmentation 1 [4.0]
Perivascular, Edema 1 [1.0]
Perivascular, Infiltration Cellular,
Eosinophil 1 [1.0]
Nose (50) (48) (50) (49)
Foreign Body 5 [2.0] 1 [3.0] 3 [1.7]
Inflammation, Suppurative 5 [2.4] 9 [1.4] 17 [1.7] 10 [1.6]
Glands, Dilatation 3 [1.7] 30 [1.2] 48 [1.5] 46 [1.5]
Goblet Cell, Hyperplasia 1 [2.0] 3 [1.7] 7 [1.7] 16 [1.6]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 12
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nasolacrimal Duct, Inflammation, Suppurative 2 [1.0] 6 [1.7] 1 [1.0] 4 [2.3]
Nasopharyngeal Duct, Cyst 1 [4.0]
Nasopharyngeal Duct, Foreign Body 1 [1.0]
Nasopharyngeal Duct, Inflammation,
Suppurative 1 [2.0]
Nasopharyngeal Duct, Respiratory Epithelium,
Hyperplasia 1 [4.0]
Olfactory Epithelium, Degeneration 47 [1.6] 49 [1.7] 49 [2.0]
Olfactory Epithelium, Degeneration, Hyaline 4 [1.3] 2 [1.0] 1 [2.0]
Olfactory Epithelium, Hyperplasia, Basal Cell 21 [1.0] 44 [1.4] 48 [1.7]
Olfactory Epithelium, Metaplasia 1 [1.0] 2 [1.5]
Respiratory Epithelium, Hyperplasia 1 [3.0]
Turbinate, Cyst 1 [2.0]
Pleura (50) (50) (50) (50)
Mesothelium, Hyperplasia 1 [2.0]
Trachea (50) (49) (50) (49)
Glands, Degeneration, Cystic 1 [2.0] 5 [1.6]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (48) (48) (49)
Anterior Chamber, Hemorrhage 1 [4.0]
Cornea, Mineralization 1 [1.0]
Lens, Cataract 2 [2.0] 1 [4.0] 3 [3.0] 1 [2.0]
Retina, Atrophy 1 [4.0]
Harderian Gland (50) (50) (50) (50)
Atrophy 1 [4.0]
Zymbal's Gland (1) (3)
Inflammation, Suppurative 1 [4.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (49)
Cyst 1 [4.0] 1 [4.0]
Nephropathy, Chronic 37 [1.8] 41 [1.5] 41 [2.1] 45 [1.8]
Cortex, Infarct 1 [4.0] 1 [2.0]
Cortex, Renal Tubule, Degeneration 1 [2.0]
Cortex, Renal Tubule, Hyperplasia 1 [2.0] 2 [1.0] 2 [4.0]
Cortex, Renal Tubule, Hypertrophy 1 [1.0]
Medulla, Infarct 1 [4.0]
Medulla, Infiltration Cellular, Lipocyte 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 13
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Papilla, Renal Tubule, Dilatation 1 [4.0]
Pelvis, Transitional Epithelium, Hyperplasia 1 [4.0] 1 [2.0]
Pelvis, Transitional Epithelium,
Mineralization 1 [3.0]
Urethra (1)
Transitional Epithelium, Hyperplasia 1 [3.0]
Urinary Bladder (50) (49) (50) (49)
Calculus Micro Observation Only 4 [2.0] 2 [2.5] 4 [3.3] 4 [2.0]
Hemorrhage 2 [3.0] 1 [4.0] 1 [3.0]
Transitional Epithelium, Hyperplasia 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 14
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