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TDMS Study 92013-06 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst                            4-METHYLIMIDAZOLE                                            DATE: 01/12/04  
EXPERIMENT: 92013 TEST: 06                                                                                        TIME: 15:01:17    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C92013B     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: SOUTHERN RESEARCH INSTITUTE                      4-METHYLIMIDAZOLE                                           DATE: 01/12/04    
EXPERIMENT: 92013 TEST: 06                                                                                        TIME: 15:21:14    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  92013B      
CONT: N01-ES-85420                                                                                                CAS: 822-36-6     
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                         
                                             CHRONIC DOSED FEED STUDY OF 4-METHYLIMIDAZOLE                                          
==================================================================================================================================  
           0 PPM                      312 PPM                            625 PPM                            1250 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     5.1    21.2       4.8     21.3    0.94       71      5.1     21.1    1.00      150      4.9     21.2    0.96      291       
  2     5.5    22.1       5.4     22.3    0.98       75      5.4     21.9    0.98      154      5.6     22.0    1.02      320       
  3     5.3    23.2       5.3     22.8    1.00       73      5.4     23.1    1.02      145      5.4     22.8    1.02      294       
  4     5.4    24.4       5.4     24.7    1.00       69      5.4     24.3    1.00      138      5.3     24.0    0.98      275       
  5     6.0    25.5       5.5     25.7    0.92       67      5.5     25.3    0.92      134      5.4     25.0    0.90      271       
  6     6.2    26.8       5.6     26.7    0.90       65      6.1     26.6    0.98      145      5.9     26.2    0.95      279       
  7     5.6    27.4       5.7     27.4    1.02       65      5.6     27.1    1.00      129      5.5     26.8    0.98      257       
  8     5.6    28.3       5.2     28.3    0.93       58      5.1     27.8    0.91      115      5.2     27.5    0.93      237       
  9     5.2    28.8       4.9     28.9    0.94       53      5.0     28.4    0.96      109      4.9     27.9    0.94      219       
 10     5.4    29.1       5.1     29.1    0.94       55      5.1     28.8    0.94      110      5.0     28.4    0.93      219       
 11     5.1    29.6       5.1     29.7    1.00       53      5.1     29.1    1.00      109      5.0     28.8    0.98      217       
 12     5.1    30.8       5.5     30.6    1.08       56      5.3     30.3    1.04      108      5.4     29.4    1.06      231       
 13     5.1    31.3       5.3     31.2    1.04       53      5.2     31.0    1.02      104      5.3     30.3    1.04      217       
 17     5.3    34.4       5.4     34.0    1.02       49      5.3     33.6    1.00       99      5.2     32.6    0.98      201       
 21     5.1    36.1       4.8     36.1    0.94       42      4.9     35.3    0.96       87      4.9     33.5    0.96      183       
 25     5.2    37.6       5.2     37.6    1.00       43      5.1     36.7    0.98       87      5.1     34.7    0.98      184       
 29     4.8    40.1       5.0     40.3    1.04       39      4.9     39.3    1.02       78      4.9     37.1    1.02      164       
 33     4.9    41.4       4.9     41.7    1.00       37      4.5     40.2    0.92       71      4.4     37.5    0.90      148       
 37     5.2    42.3       5.2     42.4    1.00       38      5.2     41.0    1.00       80      5.1     38.3    0.98      166       
 41     4.3    44.1       4.6     43.9    1.07       33      4.6     42.8    1.07       67      4.5     39.8    1.05      141       
 45     4.6    43.5       4.5     44.2    0.98       32      4.6     43.0    1.00       66      4.4     40.0    0.96      138       
 49     4.7    43.9       4.9     44.1    1.04       35      4.8     42.7    1.02       70      4.6     39.5    0.98      146       
 53     4.7    45.3       4.5     45.7    0.96       31      4.6     44.2    0.98       65      4.4     41.1    0.94      135       
 57     5.0    46.1       5.0     46.5    1.00       34      5.0     45.1    1.00       69      4.9     41.1    0.98      150       
 61     5.1    45.9       5.0     46.1    0.98       33      5.1     45.2    1.00       70      4.7     40.7    0.92      143       
 65     4.7    44.3       4.7     44.9    1.00       33      4.7     43.6    1.00       68      4.6     39.5    0.98      147       
 69     4.8    44.8       5.1     43.7    1.06       36      5.0     42.5    1.04       73      4.9     38.8    1.02      156       
 73     5.0    44.9       5.2     44.1    1.04       37      5.3     42.9    1.06       77      5.1     39.0    1.02      162       
 77     5.6    45.7       5.8     44.2    1.04       41      5.4     42.3    0.96       80      5.4     38.4    0.96      176       
 81     5.3    45.2       5.6     43.1    1.06       40      5.4     42.0    1.02       80      5.2     38.0    0.98      170       
 85     4.8    45.7       5.0     43.9    1.04       36      5.1     42.9    1.06       75      5.0     38.4    1.04      163       
 89     4.8    45.0       4.9     43.7    1.02       35      4.8     42.7    1.00       70      4.6     38.0    0.96      152       
 93     5.3    44.9       5.3     43.7    1.00       38      5.3     43.0    1.00       78      5.0     38.1    0.94      164       
 97     5.5    44.7       5.1     43.7    0.93       36      4.9     42.8    0.89       72      4.6     38.4    0.84      148       
==================================================================================================================================  
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                         
                                             CHRONIC DOSED FEED STUDY OF 4-METHYLIMIDAZOLE                                          
==================================================================================================================================  
           0 PPM                      312 PPM                            625 PPM                            1250 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
101     4.9    43.7       5.4     42.6     1.10      40      5.2     41.9     1.06      78      5.1     37.4     1.04     171       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    5.4    26.8       5.3     26.8     0.98      62      5.3     26.5     0.98     127      5.3     26.2     0.98     256       
SD(D)   0.3               0.3              0.05       8      0.3              0.04      18      0.3              0.05      35       
CV(E)   6.4               4.9              5.3     13.2      5.8              4.0     14.4      5.4              4.9     13.7       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.9    40.4       4.9     40.5     1.01      39      4.9     39.4     1.00      78      4.8     37.0     0.98     163       
SD(D)   0.3               0.3              0.04       6      0.3              0.04      11      0.3              0.04      22       
CV(E)   6.5               5.9              3.8     14.4      6.1              4.2     14.3      6.6              4.2     13.5       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    5.0    45.1       5.1     44.3     1.02      36      5.1     43.2     1.01      73      4.9     39.0     0.97     157       
SD(D)   0.3               0.3              0.05       3      0.3              0.05       5      0.3              0.06      12       
CV(E)   5.8               6.6              4.6      8.3      5.1              4.7      6.7      5.8              5.8      7.8       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                       
                                             CHRONIC DOSED FEED STUDY OF 4-METHYLIMIDAZOLE                                          
==================================================================================================================================  
           0 PPM                      312 PPM                            625 PPM                            1250 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     3.7    17.4       3.5     17.3     0.95      63      3.8     17.4     1.03     135      3.3     17.4     0.89     239       
  2     4.0    18.3       3.8     18.0     0.95      65      3.8     18.6     0.95     129      3.8     17.7     0.95     265       
  3     3.6    19.0       3.7     18.8     1.03      62      3.8     19.1     1.06     125      3.7     18.9     1.03     245       
  4     4.3    20.5       4.2     20.3     0.98      64      4.1     20.1     0.95     126      3.9     19.6     0.91     251       
  5     4.3    21.3       4.0     20.4     0.93      60      4.1     21.2     0.95     120      3.8     20.0     0.88     239       
  6     4.5    22.3       4.6     22.0     1.02      66      4.6     22.2     1.02     130      4.4     21.2     0.98     262       
  7     4.5    23.1       4.5     22.5     1.00      63      4.6     22.5     1.02     127      4.4     21.6     0.98     254       
  8     4.5    23.1       4.4     23.3     0.98      59      4.6     23.2     1.02     123      4.5     22.2     1.00     255       
  9     4.1    23.9       4.0     23.7     0.98      52      4.0     23.6     0.98     106      3.9     22.9     0.95     216       
 10     4.2    24.6       4.2     24.4     1.00      54      4.5     24.3     1.07     114      4.2     23.5     1.00     224       
 11     4.1    24.9       4.0     24.7     0.98      51      4.4     24.7     1.07     111      4.0     23.7     0.98     212       
 12     4.6    25.0       4.6     25.3     1.00      57      4.5     25.1     0.98     112      4.5     23.8     0.98     235       
 13     4.4    25.7       4.5     25.5     1.02      55      4.3     25.1     0.98     108      4.4     24.1     1.00     229       
 17     4.6    28.7       4.6     28.5     1.00      50      4.5     27.6     0.98     101      4.4     25.9     0.96     211       
 21     4.5    30.4       4.5     30.1     1.00      46      4.4     30.0     0.98      93      4.3     27.5     0.96     195       
 25     4.8    32.5       4.8     32.1     1.00      46      4.7     31.2     0.98      93      4.7     28.3     0.98     206       
 29     4.7    35.9       4.7     34.5     1.00      43      4.7     33.9     1.00      86      4.6     30.1     0.98     191       
 33     4.8    36.0       4.6     35.1     0.96      41      4.6     33.1     0.96      87      4.2     29.3     0.88     180       
 37     4.5    37.1       4.6     35.8     1.02      40      4.8     35.5     1.07      84      4.4     31.1     0.98     179       
 41     3.7    37.7       4.0     37.6     1.08      33      3.8     37.4     1.03      63      3.7     31.8     1.00     145       
 45     4.3    39.0       4.1     39.0     0.95      32      4.3     38.1     1.00      70      4.3     33.4     1.00     159       
 49     4.3    40.0       4.5     39.5     1.05      35      4.4     38.9     1.02      71      4.1     33.1     0.95     156       
 53     4.7    41.6       4.3     40.6     0.91      33      4.6     39.9     0.98      72      4.5     34.5     0.96     163       
 57     4.2    43.3       4.4     41.8     1.05      33      4.4     41.2     1.05      68      4.1     35.0     0.98     145       
 61     4.9    43.0       4.9     41.1     1.00      37      4.6     41.2     0.94      70      4.3     34.5     0.88     156       
 65     4.4    42.6       4.5     40.7     1.02      35      4.4     40.3     1.00      68      4.1     34.5     0.93     150       
 69     4.9    43.4       5.0     41.1     1.02      38      4.8     39.6     0.98      76      4.5     35.1     0.92     159       
 73     4.9    42.9       5.1     41.0     1.04      39      5.2     39.8     1.06      81      4.6     35.4     0.94     161       
 77     4.6    42.9       4.9     41.5     1.07      37      4.7     39.3     1.02      75      4.5     35.4     0.98     158       
 81     4.7    42.5       4.8     40.5     1.02      37      4.7     39.1     1.00      74      4.7     34.7     1.00     171       
 85     4.9    43.1       5.0     41.4     1.02      38      4.5     40.0     0.92      70      3.8     35.5     0.78     134       
 89     5.0    44.2       5.1     41.0     1.02      39      4.7     40.2     0.94      73      4.2     35.6     0.84     148       
 93     4.9    45.3       5.1     42.4     1.04      37      4.8     39.9     0.98      75      4.3     35.4     0.88     153       
 97     4.8    45.6       4.9     43.2     1.02      35      4.7     40.3     0.98      72      4.1     36.3     0.85     141       
==================================================================================================================================  
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                       
                                             CHRONIC DOSED FEED STUDY OF 4-METHYLIMIDAZOLE                                          
==================================================================================================================================  
           0 PPM                      312 PPM                            625 PPM                            1250 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
101     5.0    44.6       5.3     41.8     1.06      39      4.9     41.5     0.98      74      4.9     36.2     0.98     169       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.2    22.2       4.2     22.0     0.98      59      4.2     22.1     1.01     120      4.1     21.3     0.96     240       
SD(D)   0.3               0.4              0.03       5      0.3              0.04       9      0.4              0.04      17       
CV(E)   7.3               9.0              3.1      8.4      7.4              4.4      7.7      9.1              4.6      7.0       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.5    35.3       4.5     34.7     1.01      41      4.5     34.0     1.00      83      4.3     30.0     0.96     180       
SD(D)   0.3               0.3              0.04       6      0.3              0.03      13      0.3              0.04      23       
CV(E)   7.4               6.3              4.0     15.4      7.0              3.3     15.4      6.7              3.9     12.8       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.8    43.5       4.9     41.4     1.02      37      4.7     40.2     0.99      73      4.4     35.2     0.92     154       
SD(D)   0.2               0.3              0.04       2      0.2              0.04       4      0.3              0.07      11       
CV(E)   4.9               6.3              3.6      6.0      4.4              4.2      5.0      6.8              7.3      7.0       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                DIAGNOSTIC TRAILER REPORT                                                                           
                                FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                   
                                CHRONIC DOSED FEED STUDY OF 4-METHYLIMIDAZOLE                                                       
=========================================================================================================                           
           0 PPM                   312 PPM                  625 PPM                  1250 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B               21.2  50                 21.3  50                 21.1  50                 21.2  50                               
  1   5.1  6387   21.2  50     4.8  6884   21.3  50     5.1  6932   21.1  50     4.9  7095   21.2  50                               
  2   5.5  8191   22.1  50     5.4  8364   22.3  50     5.4  8111   21.9  50     5.6  8280   22.0  50                               
  3   5.3  8018   23.2  50     5.3  8400   22.8  50     5.4  8421   23.1  50     5.4  8450   22.8  50                               
  4   5.4  8415   24.4  50     5.4  8357   24.7  50     5.4  8199   24.3  50     5.3  8376   24.0  50                               
  5   6.0  8315   25.5  50     5.5  8350   25.7  50     5.5  8350   25.3  50     5.4  8411   25.0  50                               
  6   6.2  8312   26.8  50     5.6  8437   26.7  50     6.1  8412   26.6  50     5.9  8334   26.2  50                               
  7   5.6  8293   27.4  50     5.7  8304   27.4  50     5.6  8151   27.1  50     5.5  8251   26.8  50                               
  8   5.6  8431   28.3  50     5.2  8462   28.3  50     5.1  8431   27.8  49     5.2  8500   27.5  50                               
  9   5.2  8650   28.8  50     4.9  8600   28.9  50     5.0  8605   28.4  50     4.9  8550   27.9  50                               
 10   5.4  8169   29.1  50     5.1  8150   29.1  50     5.1  8150   28.8  50     5.0  8250   28.4  50                               
 11   5.1  8480   29.6  50     5.1  8458   29.7  50     5.1  8524   29.1  50     5.0  8481   28.8  50                               
 12   5.1  8362   30.8  50     5.5  8386   30.6  50     5.3  8400   30.3  50     5.4  8400   29.4  50                               
 13   5.1  8370   31.3  50     5.3  8457   31.2  50     5.2  8162   31.0  50     5.3  8288   30.3  50                               
 17   5.3  8270   34.4  50     5.4  8309   34.0  50     5.3  8194   33.6  50     5.2  8110   32.6  50                               
 21   5.1  8292   36.1  50     4.8  8350   36.1  50     4.9  8105   35.3  50     4.9  8209   33.5  50                               
 25   5.2  8469   37.6  50     5.2  8388   37.6  50     5.1  8252   36.7  50     5.1  8188   34.7  50                               
 29   4.8  8289   40.1  50     5.0  8185   40.3  50     4.9  8126   39.3  50     4.9  8062   37.1  50                               
 33   4.9  8244   41.4  50     4.9  8362   41.7  50     4.5  8279   40.2  50     4.4  8152   37.5  50                               
 37   5.2  8393   42.3  50     5.2  8290   42.4  50     5.2  8045   41.0  50     5.1  7969   38.3  50                               
 41   4.3  8338   44.1  50     4.6  8332   43.9  50     4.6  8388   42.8  50     4.5  8400   39.8  50                               
 45   4.6  8330   43.5  50     4.5  8452   44.2  50     4.6  8400   43.0  50     4.4  8298   40.0  50                               
 49   4.7  8331   43.9  50     4.9  8155   44.1  49     4.8  8209   42.7  50     4.6  7886   39.5  50                               
 53   4.7  8272   45.3  50     4.5  8152   45.7  49     4.6  8093   44.2  49     4.4  7957   41.1  49                               
 57   5.0  8286   46.1  50     5.0  8085   46.5  49     5.0  7964   45.1  49     4.9  7865   41.1  49                               
 61   5.1  8400   45.9  50     5.0  8035   46.1  49     5.1  8064   45.2  49     4.7  7971   40.7  49                               
 65   4.7  8367   44.3  50     4.7  8108   44.9  49     4.7  7900   43.6  48     4.6  8066   39.5  49                               
 69   4.8  8232   44.8  49     5.1  8013   43.7  49     5.0  7968   42.5  48     4.9  8085   38.8  49                               
 73   5.0  8259   44.9  49     5.2  8121   44.1  49     5.3  7886   42.9  48     5.1  8005   39.0  49                               
 77   5.6  7927   45.7  48     5.8  8052   44.2  49     5.4  7473   42.3  47     5.4  7883   38.4  49                               
 81   5.3  8016   45.2  48     5.6  8085   43.1  49     5.4  7376   42.0  46     5.2  7776   38.0  48                               
 85   4.8  8079   45.7  48     5.0  7976   43.9  48     5.1  7451   42.9  45     5.0  7933   38.4  48                               
 89   4.8  8053   45.0  48     4.9  7795   43.7  47     4.8  7271   42.7  45     4.6  7819   38.0  48                               
 93   5.3  7982   44.9  48     5.3  7785   43.7  47     5.3  7033   43.0  43     5.0  7492   38.1  47                               
 97   5.5  8067   44.7  48     5.1  7507   43.7  47     4.9  7116   42.8  43     4.6  7615   38.4  46                               
101   4.9  7636   43.7  46     5.4  7590   42.6  46     5.2  6677   41.9  42     5.1  7457   37.4  46                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           26.8                     26.8                     26.5                     26.2                                   
14 TO 52          40.4                     40.5                     39.4                     37.0                                   
 > 52             45.1                     44.3                     43.2                     39.0                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                DIAGNOSTIC TRAILER REPORT                                                                           
                                FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                 
                                CHRONIC DOSED FEED STUDY OF 4-METHYLIMIDAZOLE                                                       
=========================================================================================================                           
           0 PPM                   312 PPM                  625 PPM                  1250 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B               17.4  50                 17.3  50                 17.4  50                 17.4  50                               
  1   3.7  6003   17.4  50     3.5  7059   17.3  50     3.8  5667   17.4  50     3.3  7099   17.4  50                               
  2   4.0  7722   18.3  50     3.8  8064   18.0  50     3.8  8363   18.6  50     3.8  8413   17.7  50                               
  3   3.6  8298   19.0  50     3.7  8404   18.8  50     3.8  8400   19.1  50     3.7  8388   18.9  50                               
  4   4.3  8401   20.5  50     4.2  8384   20.3  50     4.1  8385   20.1  50     3.9  8363   19.6  50                               
  5   4.3  8385   21.3  50     4.0  8389   20.4  50     4.1  8381   21.2  50     3.8  8440   20.0  50                               
  6   4.5  8423   22.3  50     4.6  8408   22.0  50     4.6  8419   22.2  50     4.4  8368   21.2  50                               
  7   4.5  8391   23.1  50     4.5  8290   22.5  50     4.6  8267   22.5  50     4.4  8009   21.6  50                               
  8   4.5  8385   23.1  50     4.4  8491   23.3  50     4.6  8426   23.2  50     4.5  8481   22.2  50                               
  9   4.1  8669   23.9  50     4.0  8622   23.7  50     4.0  8374   23.6  50     3.9  8581   22.9  50                               
 10   4.2  8146   24.6  50     4.2  8159   24.4  50     4.5  8162   24.3  50     4.2  8139   23.5  50                               
 11   4.1  8521   24.9  50     4.0  8504   24.7  50     4.4  8565   24.7  50     4.0  8582   23.7  50                               
 12   4.6  8296   25.0  50     4.6  8325   25.3  50     4.5  8359   25.1  50     4.5  8144   23.8  50                               
 13   4.4  6257   25.7  50     4.5  7356   25.5  50     4.3  6019   25.1  50     4.4  5975   24.1  50                               
 17   4.6  8154   28.7  49     4.6  8257   28.5  50     4.5  8074   27.6  50     4.4  8034   25.9  50                               
 21   4.5  8115   30.4  49     4.5  8338   30.1  50     4.4  8231   30.0  50     4.3  7940   27.5  50                               
 25   4.8  8366   32.5  49     4.8  8088   32.1  50     4.7  8397   31.2  50     4.7  8274   28.3  50                               
 29   4.7  8209   35.9  49     4.7  8374   34.5  50     4.7  8221   33.9  50     4.6  8195   30.1  50                               
 33   4.8  8314   36.0  49     4.6  8428   35.1  50     4.6  8195   33.1  50     4.2  8177   29.3  50                               
 37   4.5  8323   37.1  49     4.6  8379   35.8  50     4.8  8277   35.5  50     4.4  8261   31.1  50                               
 41   3.7  8132   37.7  49     4.0  8274   37.6  50     3.8  8364   37.4  50     3.7  8398   31.8  50                               
 45   4.3  8477   39.0  49     4.1  8153   39.0  50     4.3  8504   38.1  50     4.3  8380   33.4  50                               
 49   4.3  8113   40.0  49     4.5  8241   39.5  50     4.4  8135   38.9  50     4.1  8122   33.1  50                               
 53   4.7  8363   41.6  49     4.3  8494   40.6  50     4.6  8384   39.9  50     4.5  8363   34.5  50                               
 57   4.2  8367   43.3  49     4.4  8436   41.8  50     4.4  8238   41.2  50     4.1  8211   35.0  50                               
 61   4.9  8172   43.0  49     4.9  8260   41.1  50     4.6  8225   41.2  50     4.3  7918   34.5  49                               
 65   4.4  8194   42.6  49     4.5  8266   40.7  50     4.4  8237   40.3  50     4.1  7888   34.5  48                               
 69   4.9  8185   43.4  49     5.0  8250   41.1  50     4.8  8170   39.6  50     4.5  7910   35.1  48                               
 73   4.9  8248   42.9  49     5.1  8383   41.0  50     5.2  8274   39.8  50     4.6  7910   35.4  48                               
 77   4.6  8120   42.9  49     4.9  7827   41.5  49     4.7  8125   39.3  50     4.5  7799   35.4  48                               
 81   4.7  7808   42.5  46     4.8  8214   40.5  49     4.7  8025   39.1  48     4.7  7748   34.7  47                               
 85   4.9  7675   43.1  46     5.0  8155   41.4  49     4.5  7947   40.0  48     3.8  7589   35.5  46                               
 89   5.0  7338   44.2  45     5.1  7963   41.0  49     4.7  7961   40.2  48     4.2  7440   35.6  46                               
 93   4.9  7527   45.3  45     5.1  7873   42.4  47     4.8  7708   39.9  47     4.3  7267   35.4  45                               
 97   4.8  7562   45.6  45     4.9  7486   43.2  45     4.7  7787   40.3  47     4.1  6918   36.3  43                               
101   5.0  7438   44.6  45     5.3  7092   41.8  44     4.9  7324   41.5  45     4.9  6479   36.2  41                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           22.2                     22.0                     22.1                     21.3                                   
14 TO 52          35.3                     34.7                     34.0                     30.0                                   
 > 52             43.5                     41.4                     40.2                     35.2                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.