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TDMS Study 93020-06 Pathology Tables

NTP Experiment-Test: 93020-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                          DIISOPROPYLCARBODIIMIDE (DIC)                               Date: 01/10/01
Route: SKIN APPLICATION                                                                                           Time: 11:03:02

                                                          Final#1/Mice




       Facility:  BIORELIANCE

       Chemical CAS #:  693-13-0

       Lock Date:  02/24/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 93020-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                          DIISOPROPYLCARBODIIMIDE (DIC)                               Date: 01/10/01    
Route: SKIN APPLICATION                                                                                           Time: 11:03:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:P53+/-(C57BL/6) FEMALE               VEHICLE      4.38         8.75         17.5         35 MG/KG     70 MG/KG        
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           15           15           15           15           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular, Focal, Lymphocyte         4 (27%)      1 (7%)       1 (7%)                    2 (13%)      5 (33%)     
      Infiltration Cellular, Lymphocyte                                          1 (7%)                                             
      Inflammation, Chronic Active, Focal              1 (7%)                                                                       
      Hepatocyte, Necrosis, Focal                      1 (7%)       1 (7%)       3 (20%)      8 (53%)      4 (27%)      3 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (14)         (14)         (15)         
      Subcapsular, Hyperplasia, Focal                 12 (80%)      7 (47%)     10 (67%)     12 (86%)     12 (86%)     15 (100%)    
      Zona Glomerulosa, Hyperplasia, Focal                                                                              1 (7%)      
   Parathyroid Gland                                  (10)         (5)          (4)          (4)          (9)          (5)          
      Cyst                                                                                                              1 (20%)     
   Thyroid Gland                                      (15)         (14)         (14)         (15)         (15)         (15)         
      Ectopic Thymus                                   2 (13%)                   1 (7%)       2 (13%)      1 (7%)       1 (7%)      
      Follicular Cell, Hyperplasia, Focal              1 (7%)                                                                       
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Uterus                                             (15)         (15)         (15)         (15)         (15)         (15)         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
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NTP Experiment-Test: 93020-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                          DIISOPROPYLCARBODIIMIDE (DIC)                               Date: 01/10/01    
Route: SKIN APPLICATION                                                                                           Time: 11:03:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:P53+/-(C57BL/6) FEMALE               VEHICLE      4.38         8.75         17.5         35 MG/KG     70 MG/KG        
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hydrometra                                                                                                        1 (7%)      
      Endometrium, Hyperplasia, Cystic                14 (93%)     14 (93%)     14 (93%)     14 (93%)     14 (93%)     13 (87%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                                                                            (1)          (1)          
      Myeloid Cell, Hyperplasia                                                                                         1 (100%)    
   Lymph Node                                                                                (1)                                    
      Inguinal, Hyperplasia, Lymphoid                                                         1 (100%)                              
   Lymph Node, Mandibular                             (15)         (15)         (15)         (14)         (15)         (15)         
      Hyperplasia, Lymphoid                            2 (13%)                   2 (13%)                                1 (7%)      
   Lymph Node, Mediastinal                            (15)         (14)         (13)         (15)         (12)         (15)         
      Hyperplasia, Lymphoid                            2 (13%)                                                                      
   Spleen                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                14 (93%)     15 (100%)    15 (100%)    15 (100%)    14 (93%)     15 (100%)    
      Pigmentation                                     1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Dermis, Fibrosis                                                                                                  1 (7%)      
      Dermis, Infiltration Cellular, Mast Cell                                                                          2 (13%)     
      Epidermis, Control, Hyperplasia, Focal           1 (7%)                                                                       
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                                                                                   8 (53%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia, Diffuse                                                                                          1 (7%)      
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia, Focal                                                                                            1 (7%)      
      Sebaceous Gland, Hypertrophy                                                                                      1 (7%)      
      Subcutaneous Tissue, Metaplasia, Focal,                                                                                       
          Osseous                                                                                                       1 (7%)      
      Vulva, Degeneration                                                                                               1 (7%)      
      Vulva, Ulcer, Chronic, Focal                                                                                      1 (7%)      
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
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NTP Experiment-Test: 93020-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                          DIISOPROPYLCARBODIIMIDE (DIC)                               Date: 01/10/01    
Route: SKIN APPLICATION                                                                                           Time: 11:03:02    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:P53+/-(C57BL/6) FEMALE               VEHICLE      4.38         8.75         17.5         35 MG/KG     70 MG/KG        
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Alveolus, Hemorrhage, Focal                      1 (7%)       1 (7%)                                                          
      Alveolus, Inflammation, Chronic Active, Focal                                           1 (7%)       1 (7%)                   
      Perivascular, Infiltration Cellular, Focal,                                                                                   
           Lymphocyte                                                                                      1 (7%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular, Focal, Lymphocyte         1 (7%)       2 (13%)                                                         
      Pelvis, Infiltration Cellular, Focal,                                                                                         
          Lymphocyte                                                                                       1 (7%)                   
      Renal Tubule, Degeneration, Focal                1 (7%)                                                                       
      Renal Tubule, Dilatation, Focal                  4 (27%)      1 (7%)       1 (7%)                                 3 (20%)     
      Renal Tubule, Hyperplasia                                                                                         1 (7%)      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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