https://ntp.niehs.nih.gov/go/18934

TDMS Study 93020-06 Pathology Tables

NTP Experiment-Test: 93020-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                          DIISOPROPYLCARBODIIMIDE (DIC)                               Date: 01/10/01
Route: SKIN APPLICATION                                                                                           Time: 11:03:02
                                                          Final#1/Mice
       Facility:  BIORELIANCE
       Chemical CAS #:  693-13-0
       Lock Date:  02/24/00
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93020-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                          DIISOPROPYLCARBODIIMIDE (DIC)                               Date: 01/10/01    
Route: SKIN APPLICATION                                                                                           Time: 11:03:02    
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         MICE:P53+/-(C57BL/6) FEMALE               VEHICLE      4.38         8.75         17.5         35 MG/KG     70 MG/KG        
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           15           15           15           15           
  Animals Examined Microscopically                    15           15           15           15           15           15           
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 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular, Focal, Lymphocyte         4 (27%)      1 (7%)       1 (7%)                    2 (13%)      5 (33%)     
      Infiltration Cellular, Lymphocyte                                          1 (7%)                                             
      Inflammation, Chronic Active, Focal              1 (7%)                                                                       
      Hepatocyte, Necrosis, Focal                      1 (7%)       1 (7%)       3 (20%)      8 (53%)      4 (27%)      3 (20%)     
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (15)         (15)         (15)         (14)         (14)         (15)         
      Subcapsular, Hyperplasia, Focal                 12 (80%)      7 (47%)     10 (67%)     12 (86%)     12 (86%)     15 (100%)    
      Zona Glomerulosa, Hyperplasia, Focal                                                                              1 (7%)      
   Parathyroid Gland                                  (10)         (5)          (4)          (4)          (9)          (5)          
      Cyst                                                                                                              1 (20%)     
   Thyroid Gland                                      (15)         (14)         (14)         (15)         (15)         (15)         
      Ectopic Thymus                                   2 (13%)                   1 (7%)       2 (13%)      1 (7%)       1 (7%)      
      Follicular Cell, Hyperplasia, Focal              1 (7%)                                                                       
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   Uterus                                             (15)         (15)         (15)         (15)         (15)         (15)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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NTP Experiment-Test: 93020-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                          DIISOPROPYLCARBODIIMIDE (DIC)                               Date: 01/10/01    
Route: SKIN APPLICATION                                                                                           Time: 11:03:02    
____________________________________________________________________________________________________________________________________
         MICE:P53+/-(C57BL/6) FEMALE               VEHICLE      4.38         8.75         17.5         35 MG/KG     70 MG/KG        
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT                                                                                                               
      Hydrometra                                                                                                        1 (7%)      
      Endometrium, Hyperplasia, Cystic                14 (93%)     14 (93%)     14 (93%)     14 (93%)     14 (93%)     13 (87%)     
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 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                                                                            (1)          (1)          
      Myeloid Cell, Hyperplasia                                                                                         1 (100%)    
   Lymph Node                                                                                (1)                                    
      Inguinal, Hyperplasia, Lymphoid                                                         1 (100%)                              
   Lymph Node, Mandibular                             (15)         (15)         (15)         (14)         (15)         (15)         
      Hyperplasia, Lymphoid                            2 (13%)                   2 (13%)                                1 (7%)      
   Lymph Node, Mediastinal                            (15)         (14)         (13)         (15)         (12)         (15)         
      Hyperplasia, Lymphoid                            2 (13%)                                                                      
   Spleen                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Hematopoietic Cell Proliferation                14 (93%)     15 (100%)    15 (100%)    15 (100%)    14 (93%)     15 (100%)    
      Pigmentation                                     1 (7%)                                                                       
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 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Dermis, Fibrosis                                                                                                  1 (7%)      
      Dermis, Infiltration Cellular, Mast Cell                                                                          2 (13%)     
      Epidermis, Control, Hyperplasia, Focal           1 (7%)                                                                       
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                                                                                   8 (53%)     
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia, Diffuse                                                                                          1 (7%)      
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia, Focal                                                                                            1 (7%)      
      Sebaceous Gland, Hypertrophy                                                                                      1 (7%)      
      Subcutaneous Tissue, Metaplasia, Focal,                                                                                       
          Osseous                                                                                                       1 (7%)      
      Vulva, Degeneration                                                                                               1 (7%)      
      Vulva, Ulcer, Chronic, Focal                                                                                      1 (7%)      
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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NTP Experiment-Test: 93020-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                          DIISOPROPYLCARBODIIMIDE (DIC)                               Date: 01/10/01    
Route: SKIN APPLICATION                                                                                           Time: 11:03:02    
____________________________________________________________________________________________________________________________________
         MICE:P53+/-(C57BL/6) FEMALE               VEHICLE      4.38         8.75         17.5         35 MG/KG     70 MG/KG        
                                                   CONTROL      MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Alveolus, Hemorrhage, Focal                      1 (7%)       1 (7%)                                                          
      Alveolus, Inflammation, Chronic Active, Focal                                           1 (7%)       1 (7%)                   
      Perivascular, Infiltration Cellular, Focal,                                                                                   
           Lymphocyte                                                                                      1 (7%)                   
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   Kidney                                             (15)         (15)         (15)         (15)         (15)         (15)         
      Infiltration Cellular, Focal, Lymphocyte         1 (7%)       2 (13%)                                                         
      Pelvis, Infiltration Cellular, Focal,                                                                                         
          Lymphocyte                                                                                       1 (7%)                   
      Renal Tubule, Degeneration, Focal                1 (7%)                                                                       
      Renal Tubule, Dilatation, Focal                  4 (27%)      1 (7%)       1 (7%)                                 3 (20%)     
      Renal Tubule, Hyperplasia                                                                                         1 (7%)      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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