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TDMS Study 88004-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 08/14/03       
EXPERIMENT: 88004 TEST: 06                                                                                     TIME: 13:01:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: GRUMBEIN, SONDR                                                                                   CAS: 1321-74-0       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 08/14/03       
EXPERIMENT: 88004 TEST: 06                                                                                     TIME: 13:01:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: GRUMBEIN, SONDR                                                                                   CAS: 1321-74-0       
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Brain                                                                              
                                                 Epididymis                                                                         
                                                 Gallbladder                                                                        
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 08/14/03       
EXPERIMENT: 88004 TEST: 06                                                                                     TIME: 13:01:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: GRUMBEIN, SONDR                                                                                   CAS: 1321-74-0       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                     DIVINYLBENZENE                                                                               
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Adenoma                                                                                      
Adrenal Medulla                        Pheochromocytoma Benign                                                                      
Heart                                  Hemangiosarcoma                                                                              
Liver                                  Hemangiosarcoma                                                                              
                                       Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Skin                                   Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                 
                                       Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                  
All Organs                             Hemangiosarcoma                                                                              
                                       Hemangiosarcoma or Hemangioma                                                                
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Medulla                        Pheochromocytoma Malignant                                                                   
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Ovary                                  Cystadenoma                                                                                  
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
All Organs                             Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type      
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                      DIVINYLBENZENE            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    1/49 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/45.45      1/45.52      0/46.42      0/47.18     |0/42.71      0/44.99      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     6.6%         2.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/41 (7%)    1/38 (3%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.101N     P=0.333N     P=0.117N     P=0.113N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.104N     P=0.305N     P=0.115N     P=0.112N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.105N     P=0.306N     P=0.115N     P=0.114N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.103N     P=0.304N     P=0.114N     P=0.110N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.101N     P=0.333N     (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.107N     P=0.309N     P=0.117N     P=0.117N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.018N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.45      0/45.52      0/46.42      0/47.18     |0/41.71      0/44.99      1/43.89      0/46.93      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     2/41 (5%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/32 (0%)    0/35 (0%)    1/38 (3%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.251N     P=0.255N     P=0.233N     P=0.228N    |P=0.744N     (e)          P=0.534      (e)          | 
|POLY 3             |     P=0.257N     P=0.237N     P=0.232N     P=0.229N    |P=0.765N     (e)          P=0.510      (e)          | 
|POLY 1.5           |     P=0.257N     P=0.237N     P=0.233N     P=0.231N    |P=0.771N     (e)          P=0.507      (e)          | 
|POLY 6             |     P=0.257N     P=0.236N     P=0.232N     P=0.226N    |P=0.756N     (e)          P=0.515      (e)          | 
|LOGISTIC REGRESSION|     P=0.251N     (e)          (e)          (e)         |(e)          (e)          P=0.534      (e)          | 
|COCH-ARM / FISHERS |     P=0.259N     P=0.247N     P=0.242N     P=0.242N    |P=0.777N     (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.027N*    (e)          (e)          (e)         |P=0.391      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/45.45      0/45.52      1/46.42      0/47.18     |0/41.71      0/44.99      0/43.89      2/46.93      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |0.0%         0.0%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/41 (0%)    0/38 (0%)    1/42 (2%)    0/43 (0%)   |0/32 (0%)    0/35 (0%)    0/38 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.767N     (e)          P=0.505      (e)         |P=0.061      (e)          (e)          P=0.300      | 
|POLY 3             |     P=0.773N     (e)          P=0.504      (e)         |P=0.046 *    (e)          (e)          P=0.264      | 
|POLY 1.5           |     P=0.775N     (e)          P=0.504      (e)         |P=0.044 *    (e)          (e)          P=0.254      | 
|POLY 6             |     P=0.771N     (e)          P=0.505      (e)         |P=0.049 *    (e)          (e)          P=0.278      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.505      (e)         |(e)          (e)          (e)          P=0.300      | 
|COCH-ARM / FISHERS |     P=0.777N     (e)          P=0.505      (e)         |P=0.043 *    (e)          (e)          P=0.253      | 
|ORDER RESTRICTED   |     P=0.385      (e)          (e)          (e)         |P=0.040 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/49 (0%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/45.45      0/45.52      1/46.42      0/47.18     |0/41.71      0/44.99      1/43.89      2/46.93      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         2.2%         0.0%        |0.0%         0.0%         2.3%         4.3%         | 
|TERMINAL (d)       |     2/41 (5%)    0/38 (0%)    1/42 (2%)    0/43 (0%)   |0/32 (0%)    0/35 (0%)    1/38 (3%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          ---          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.261N     P=0.255N     P=0.492N     P=0.228N    |P=0.127      (e)          P=0.534      P=0.300      | 
|POLY 3             |     P=0.269N     P=0.237N     P=0.493N     P=0.229N    |P=0.104      (e)          P=0.510      P=0.264      | 
|POLY 1.5           |     P=0.270N     P=0.237N     P=0.493N     P=0.231N    |P=0.098      (e)          P=0.507      P=0.254      | 
|POLY 6             |     P=0.266N     P=0.236N     P=0.492N     P=0.226N    |P=0.113      (e)          P=0.515      P=0.278      | 
|LOGISTIC REGRESSION|     P=0.261N     (e)          P=0.492N     (e)         |(e)          (e)          P=0.534      P=0.300      | 
|COCH-ARM / FISHERS |     P=0.272N     P=0.247N     P=0.492N     P=0.242N    |P=0.092      (e)          P=0.500      P=0.253      | 
|ORDER RESTRICTED   |     P=0.069N     (e)          (e)          (e)         |P=0.093      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/48 (2%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    2/49 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.11      1/45.48      0/46.42      0/47.18     |0/41.88      2/44.33      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         0.0%         0.0%        |0.0%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/41 (2%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    1/35 (3%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     609          716          ---          ---         |---          656          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.179N     P=0.512N     P=0.237N     P=0.232N    |P=0.359N     P=0.249      (e)          (e)          | 
|POLY 3             |     P=0.183N     P=0.505N     P=0.236N     P=0.232N    |P=0.365N     P=0.250      (e)          (e)          | 
|POLY 1.5           |     P=0.184N     P=0.508N     P=0.236N     P=0.234N    |P=0.374N     P=0.246      (e)          (e)          | 
|POLY 6             |     P=0.182N     P=0.504N     P=0.235N     P=0.230N    |P=0.355N     P=0.253      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.186N     P=0.557N     P=0.247N     P=0.254N    |P=0.388N     P=0.238      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.183N     P=0.515N     P=0.247N     P=0.247N    |P=0.388N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.072N     (e)          (e)          (e)         |P=0.237N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    6/50 (12%)   7/50 (14%)  |4/50 (8%)    1/50 (2%)    4/50 (8%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     5/45.69      3/46.01      6/46.42      7/47.18     |4/43.26      1/44.99      4/43.99      5/46.96      | 
|POLY-3 PERCENT (g) |     10.9%        6.5%         12.9%        14.8%       |9.3%         2.2%         9.1%         10.7%        | 
|TERMINAL (d)       |     5/41 (12%)   2/38 (5%)    6/42 (14%)   7/43 (16%)  |2/33 (6%)    1/35 (3%)    4/38 (11%)   4/42 (10%)   | 
|FIRST INCIDENCE    |     729 (T)      711          729 (T)      729 (T)     |596          731 (T)      731 (T)      725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.252      P=0.396N     P=0.517      P=0.412     |P=0.343      P=0.167N     P=0.576N     P=0.633N     | 
|POLY 3             |     P=0.221      P=0.353N     P=0.511      P=0.402     |P=0.258      P=0.167N     P=0.634N     P=0.551      | 
|POLY 1.5           |     P=0.214      P=0.355N     P=0.507      P=0.393     |P=0.241      P=0.170N     P=0.638N     P=0.528      | 
|POLY 6             |     P=0.231      P=0.351N     P=0.516      P=0.414     |P=0.283      P=0.166N     P=0.629N     P=0.579      | 
|LOGISTIC REGRESSION|     P=0.249      P=0.362N     P=0.517      P=0.412     |P=0.277      P=0.171N     P=0.629N     P=0.543      | 
|COCH-ARM / FISHERS |     P=0.204      P=0.357N     P=0.500      P=0.380     |P=0.228      P=0.181N     P=0.643N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.281      (e)          (e)          (e)         |P=0.299      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    4/50 (8%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/45.69      1/45.94      0/46.42      0/47.18     |2/42.88      4/44.99      1/43.99      2/46.93      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         0.0%         0.0%        |4.7%         8.9%         2.3%         4.3%         | 
|TERMINAL (d)       |     1/41 (2%)    1/38 (3%)    0/42 (0%)    0/43 (0%)   |1/33 (3%)    4/35 (11%)   1/38 (3%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |687          731 (T)      731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.311N     P=0.745      P=0.495N     P=0.490N    |P=0.365N     P=0.368      P=0.456N     P=0.605N     | 
|POLY 3             |     P=0.323N     P=0.759N     P=0.497N     P=0.494N    |P=0.430N     P=0.359      P=0.491N     P=0.661N     | 
|POLY 1.5           |     P=0.324N     P=0.760N     P=0.498N     P=0.496N    |P=0.447N     P=0.354      P=0.495N     P=0.676N     | 
|POLY 6             |     P=0.322N     P=0.759N     P=0.495N     P=0.490N    |P=0.410N     P=0.362      P=0.486N     P=0.642N     | 
|LOGISTIC REGRESSION|     P=0.311N     P=0.745      (e)          (e)         |P=0.392N     P=0.367      P=0.487N     P=0.657N     | 
|COCH-ARM / FISHERS |     P=0.325N     P=0.753N     P=0.500N     P=0.500N    |P=0.465N     P=0.339      P=0.500N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.245N     (e)          (e)          (e)         |P=0.355N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    6/50 (12%)   7/50 (14%)  |6/50 (12%)   5/50 (10%)   5/50 (10%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     6/45.69      4/46.01      6/46.42      7/47.18     |6/43.43      5/44.99      5/43.99      7/46.96      | 
|POLY-3 PERCENT (g) |     13.1%        8.7%         12.9%        14.8%       |13.8%        11.1%        11.4%        14.9%        | 
|TERMINAL (d)       |     6/41 (15%)   3/38 (8%)    6/42 (14%)   7/43 (16%)  |3/33 (9%)    5/35 (14%)   5/38 (13%)   6/42 (14%)   | 
|FIRST INCIDENCE    |     729 (T)      711          729 (T)      729 (T)     |596          731 (T)      731 (T)      725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.385      P=0.415N     P=0.605N     P=0.537     |P=0.536      P=0.458N     P=0.417N     P=0.559N     | 
|POLY 3             |     P=0.347      P=0.365N     P=0.610N     P=0.525     |P=0.417      P=0.475N     P=0.491N     P=0.560      | 
|POLY 1.5           |     P=0.338      P=0.368N     P=0.614N     P=0.514     |P=0.391      P=0.480N     P=0.494N     P=0.533      | 
|POLY 6             |     P=0.359      P=0.364N     P=0.605N     P=0.538     |P=0.453      P=0.477N     P=0.486N     P=0.591      | 
|LOGISTIC REGRESSION|     P=0.383      P=0.378N     P=0.605N     P=0.537     |P=0.458      P=0.465N     P=0.479N     P=0.561      | 
|COCH-ARM / FISHERS |     P=0.325      P=0.370N     P=0.620N     P=0.500     |P=0.367      P=0.500N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.448      (e)          (e)          (e)         |P=0.540      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.95      0/45.52      0/46.42      0/47.18     |0/42.71      0/44.99      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/41 (2%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     662          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.252N     P=0.248N     P=0.235N     P=0.227N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.261N     P=0.239N     P=0.235N     P=0.231N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.260N     P=0.240N     P=0.236N     P=0.234N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.260N     P=0.239N     P=0.234N     P=0.229N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.264N     P=0.243N     P=0.240N     P=0.243N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.261N     P=0.253N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.027N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Jejunum                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    4/50 (8%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/46.11      0/45.94      0/46.42      4/47.74     |0/42.71      2/44.99      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     6.5%         0.0%         0.0%         8.4%        |0.0%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/41 (5%)    0/38 (0%)    0/42 (0%)    3/43 (7%)   |0/33 (0%)    2/35 (6%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     609          ---          ---          558         |---          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.136      P=0.131N     P=0.120N     P=0.522     |P=0.350N     P=0.251      (e)          (e)          | 
|POLY 3             |     P=0.122      P=0.119N     P=0.118N     P=0.519     |P=0.370N     P=0.249      (e)          (e)          | 
|POLY 1.5           |     P=0.120      P=0.119N     P=0.118N     P=0.511     |P=0.378N     P=0.246      (e)          (e)          | 
|POLY 6             |     P=0.126      P=0.120N     P=0.117N     P=0.528     |P=0.360N     P=0.251      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.108      P=0.120N     P=0.124N     P=0.476     |(e)          P=0.251      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.119      P=0.121N     P=0.121N     P=0.500     |P=0.392N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.082      (e)          (e)          (e)         |P=0.240N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    5/50 (10%)  |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/46.11      1/46.26      0/46.42      5/47.74     |0/42.71      2/44.99      1/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     6.5%         2.2%         0.0%         10.5%       |0.0%         4.5%         2.3%         0.0%         | 
|TERMINAL (d)       |     2/41 (5%)    0/38 (0%)    0/42 (0%)    4/43 (9%)   |0/33 (0%)    2/35 (6%)    1/38 (3%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     609          641          ---          558         |---          731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.098      P=0.317N     P=0.120N     P=0.381     |P=0.330N     P=0.251      P=0.528      (e)          | 
|POLY 3             |     P=0.084      P=0.304N     P=0.118N     P=0.376     |P=0.353N     P=0.249      P=0.506      (e)          | 
|POLY 1.5           |     P=0.082      P=0.305N     P=0.118N     P=0.368     |P=0.366N     P=0.246      P=0.503      (e)          | 
|POLY 6             |     P=0.086      P=0.304N     P=0.117N     P=0.385     |P=0.338N     P=0.251      P=0.510      (e)          | 
|LOGISTIC REGRESSION|     P=0.072      P=0.302N     P=0.124N     P=0.337     |(e)          P=0.251      P=0.528      (e)          | 
|COCH-ARM / FISHERS |     P=0.081      P=0.309N     P=0.121N     P=0.357     |P=0.383N     P=0.247      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.060      (e)          (e)          (e)         |P=0.318N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/46.36      1/45.99      0/46.42      0/47.18     |0/41.88      0/44.99      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     6.5%         2.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/41 (2%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     609          716          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.105N     P=0.318N     P=0.121N     P=0.116N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.106N     P=0.308N     P=0.119N     P=0.116N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.107N     P=0.307N     P=0.119N     P=0.117N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.105N     P=0.311N     P=0.119N     P=0.114N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.115N     P=0.303N     P=0.128N     P=0.133N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.110N     P=0.309N     P=0.121N     P=0.121N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.019N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatoblastoma                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.69      0/45.94      2/47.35      0/47.18     |0/41.88      0/44.99      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.2%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/41 (0%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          479          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.668N     (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.666N     (e)          P=0.245      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.670N     (e)          P=0.242      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.660N     (e)          P=0.249      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.747N     (e)          P=0.179      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.675N     (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.254      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  17/50 (34%)  12/50 (24%)  12/50 (24%) |17/49 (35%)  7/50 (14%)   6/50 (12%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     22/46.70     17/47.51     12/47.55     12/47.18    |17/42.80     7/45.62      6/44.08      5/46.93      | 
|POLY-3 PERCENT (g) |     47.1%        35.8%        25.2%        25.4%       |39.7%        15.4%        13.6%        10.7%        | 
|TERMINAL (d)       |     20/41 (49%)  13/38 (34%)  9/42 (21%)   12/43 (28%) |13/33 (39%)  5/35 (14%)   5/38 (13%)   5/42 (12%)   | 
|FIRST INCIDENCE    |     456          543          526          729 (T)     |625          537          709          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028N*    P=0.290N     P=0.028N*    P=0.019N*   |P=0.006N**   P=0.014N*    P=0.004N**   P<0.001N**   | 
|POLY 3             |     P=0.039N*    P=0.181N     P=0.020N*    P=0.022N*   |P=0.010N*    P=0.008N**   P=0.004N**   P<0.001N**   | 
|POLY 1.5           |     P=0.040N*    P=0.193N     P=0.023N*    P=0.024N*   |P=0.012N*    P=0.009N**   P=0.005N**   P<0.001N**   | 
|POLY 6             |     P=0.037N*    P=0.167N     P=0.018N*    P=0.019N*   |P=0.008N**   P=0.008N**   P=0.004N**   P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.039N*    P=0.204N     P=0.027N*    P=0.020N*   |P=0.010N*    P=0.010N*    P=0.005N**   P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.043N*    P=0.206N     P=0.028N*    P=0.028N*   |P=0.017N*    P=0.015N*    P=0.007N**   P=0.003N**   | 
|ORDER RESTRICTED   |     P=0.015N*    (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  11/50 (22%)  9/50 (18%)   10/50 (20%) |5/49 (10%)   4/50 (8%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     13/47.80     11/47.65     9/48.87      10/47.79    |5/42.74      4/45.04      3/44.67      2/46.93      | 
|POLY-3 PERCENT (g) |     27.2%        23.1%        18.4%        20.9%       |11.7%        8.9%         6.7%         4.3%         | 
|TERMINAL (d)       |     8/41 (20%)   5/38 (13%)   4/42 (10%)   9/43 (21%)  |3/33 (9%)    3/35 (9%)    2/38 (5%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     565          600          479          533         |586          719          501          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.298N     P=0.447N     P=0.236N     P=0.287N    |P=0.129N     P=0.465N     P=0.313N     P=0.149N     | 
|POLY 3             |     P=0.347N     P=0.411N     P=0.216N     P=0.317N    |P=0.162N     P=0.467N     P=0.332N     P=0.180N     | 
|POLY 1.5           |     P=0.345N     P=0.411N     P=0.223N     P=0.316N    |P=0.173N     P=0.471N     P=0.337N     P=0.192N     | 
|POLY 6             |     P=0.352N     P=0.411N     P=0.212N     P=0.321N    |P=0.147N     P=0.470N     P=0.327N     P=0.166N     | 
|LOGISTIC REGRESSION|     P=0.403N     P=0.411N     P=0.264N     P=0.347N    |P=0.181N     P=0.470N     P=0.351N     P=0.204N     | 
|COCH-ARM / FISHERS |     P=0.346N     P=0.408N     P=0.235N     P=0.318N    |P=0.183N     P=0.487N     P=0.346N     P=0.210N     | 
|ORDER RESTRICTED   |     P=0.300N     (e)          (e)          (e)         |P=0.148N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  11/50 (22%)  9/50 (18%)   10/50 (20%) |5/49 (10%)   4/50 (8%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     13/47.80     11/47.65     9/48.87      10/47.79    |5/42.74      4/45.04      3/44.67      2/46.93      | 
|POLY-3 PERCENT (g) |     27.2%        23.1%        18.4%        20.9%       |11.7%        8.9%         6.7%         4.3%         | 
|TERMINAL (d)       |     8/41 (20%)   5/38 (13%)   4/42 (10%)   9/43 (21%)  |3/33 (9%)    3/35 (9%)    2/38 (5%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     565          600          479          533         |586          719          501          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.298N     P=0.447N     P=0.236N     P=0.287N    |P=0.129N     P=0.465N     P=0.313N     P=0.149N     | 
|POLY 3             |     P=0.347N     P=0.411N     P=0.216N     P=0.317N    |P=0.162N     P=0.467N     P=0.332N     P=0.180N     | 
|POLY 1.5           |     P=0.345N     P=0.411N     P=0.223N     P=0.316N    |P=0.173N     P=0.471N     P=0.337N     P=0.192N     | 
|POLY 6             |     P=0.352N     P=0.411N     P=0.212N     P=0.321N    |P=0.147N     P=0.470N     P=0.327N     P=0.166N     | 
|LOGISTIC REGRESSION|     P=0.403N     P=0.411N     P=0.264N     P=0.347N    |P=0.181N     P=0.470N     P=0.351N     P=0.204N     | 
|COCH-ARM / FISHERS |     P=0.346N     P=0.408N     P=0.235N     P=0.318N    |P=0.183N     P=0.487N     P=0.346N     P=0.210N     | 
|ORDER RESTRICTED   |     P=0.300N     (e)          (e)          (e)         |P=0.148N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     30/50 (60%)  26/50 (52%)  20/50 (40%)  22/50 (44%) |19/49 (39%)  10/50 (20%)  8/50 (16%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     30/48.55     26/48.90     20/50.00     22/47.79    |19/43.29     10/45.66     8/44.75      7/46.93      | 
|POLY-3 PERCENT (g) |     61.8%        53.2%        40.0%        46.0%       |43.9%        21.9%        17.9%        14.9%        | 
|TERMINAL (d)       |     24/41 (59%)  17/38 (45%)  12/42 (29%)  21/43 (49%) |14/33 (42%)  7/35 (20%)   6/38 (16%)   7/42 (17%)   | 
|FIRST INCIDENCE    |     456          543          479          533         |586          537          501          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.084N     P=0.394N     P=0.051N     P=0.062N    |P=0.006N**   P=0.031N*    P=0.006N**   P<0.001N**   | 
|POLY 3             |     P=0.131N     P=0.256N     P=0.023N*    P=0.086N    |P=0.012N*    P=0.021N*    P=0.006N**   P=0.002N**   | 
|POLY 1.5           |     P=0.122N     P=0.267N     P=0.027N*    P=0.083N    |P=0.014N*    P=0.023N*    P=0.007N**   P=0.002N**   | 
|POLY 6             |     P=0.145N     P=0.241N     P=0.019N*    P=0.092N    |P=0.009N**   P=0.021N*    P=0.006N**   P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.131N     P=0.275N     P=0.039N*    P=0.077N    |P=0.013N*    P=0.023N*    P=0.008N**   P=0.002N**   | 
|COCH-ARM / FISHERS |     P=0.112N     P=0.273N     P=0.036N*    P=0.080N    |P=0.019N*    P=0.033N*    P=0.010N*    P=0.005N**   | 
|ORDER RESTRICTED   |     P=0.045N*    (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     30/50 (60%)  26/50 (52%)  20/50 (40%)  22/50 (44%) |19/49 (39%)  10/50 (20%)  8/50 (16%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     30/48.55     26/48.90     20/50.00     22/47.79    |19/43.29     10/45.66     8/44.75      7/46.93      | 
|POLY-3 PERCENT (g) |     61.8%        53.2%        40.0%        46.0%       |43.9%        21.9%        17.9%        14.9%        | 
|TERMINAL (d)       |     24/41 (59%)  17/38 (45%)  12/42 (29%)  21/43 (49%) |14/33 (42%)  7/35 (20%)   6/38 (16%)   7/42 (17%)   | 
|FIRST INCIDENCE    |     456          543          479          533         |586          537          501          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.084N     P=0.394N     P=0.051N     P=0.062N    |P=0.006N**   P=0.031N*    P=0.006N**   P<0.001N**   | 
|POLY 3             |     P=0.131N     P=0.256N     P=0.023N*    P=0.086N    |P=0.012N*    P=0.021N*    P=0.006N**   P=0.002N**   | 
|POLY 1.5           |     P=0.122N     P=0.267N     P=0.027N*    P=0.083N    |P=0.014N*    P=0.023N*    P=0.007N**   P=0.002N**   | 
|POLY 6             |     P=0.145N     P=0.241N     P=0.019N*    P=0.092N    |P=0.009N**   P=0.021N*    P=0.006N**   P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.131N     P=0.275N     P=0.039N*    P=0.077N    |P=0.013N*    P=0.023N*    P=0.008N**   P=0.002N**   | 
|COCH-ARM / FISHERS |     P=0.112N     P=0.273N     P=0.036N*    P=0.080N    |P=0.019N*    P=0.033N*    P=0.010N*    P=0.005N**   | 
|ORDER RESTRICTED   |     P=0.045N*    (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/49 (24%)  6/49 (12%)   6/49 (12%)   15/49 (31%) |4/50 (8%)    9/50 (18%)   4/50 (8%)    8/49 (16%)   | 
|POLY-3 RATE (b)    |     12/46.05     6/45.52      6/46.05      15/47.42    |4/42.71      9/44.99      4/44.08      8/46.89      | 
|POLY-3 PERCENT (g) |     26.1%        13.2%        13.0%        31.6%       |9.4%         20.0%        9.1%         17.1%        | 
|TERMINAL (d)       |     11/41 (27%)  6/38 (16%)   6/42 (14%)   13/43 (30%) |4/33 (12%)   9/35 (26%)   3/38 (8%)    7/42 (17%)   | 
|FIRST INCIDENCE    |     536          729 (T)      729 (T)      598         |731 (T)      731 (T)      709          697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.091      P=0.126N     P=0.087N     P=0.381     |P=0.469      P=0.134      P=0.565N     P=0.315      | 
|POLY 3             |     P=0.067      P=0.097N     P=0.093N     P=0.358     |P=0.352      P=0.134      P=0.626N     P=0.225      | 
|POLY 1.5           |     P=0.063      P=0.097N     P=0.094N     P=0.343     |P=0.316      P=0.129      P=0.633N     P=0.199      | 
|POLY 6             |     P=0.075      P=0.098N     P=0.091N     P=0.381     |P=0.399      P=0.137      P=0.615N     P=0.259      | 
|LOGISTIC REGRESSION|     P=0.070      P=0.094N     P=0.090N     P=0.340     |P=0.446      P=0.134      P=0.592N     P=0.289      | 
|COCH-ARM / FISHERS |     P=0.060      P=0.096N     P=0.096N     P=0.326     |P=0.276      P=0.117      P=0.643N     P=0.168      | 
|ORDER RESTRICTED   |     P=0.063      (e)          (e)          (e)         |P=0.233      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   4/49 (8%)    3/49 (6%)    9/49 (18%)  |2/50 (4%)    5/50 (10%)   4/50 (8%)    5/49 (10%)   | 
|POLY-3 RATE (b)    |     5/45.45      4/45.59      3/46.05      9/47.20     |2/42.71      5/45.04      4/44.59      5/46.77      | 
|POLY-3 PERCENT (g) |     11.0%        8.8%         6.5%         19.1%       |4.7%         11.1%        9.0%         10.7%        | 
|TERMINAL (d)       |     5/41 (12%)   3/38 (8%)    3/42 (7%)    7/43 (16%)  |2/33 (6%)    4/35 (11%)   3/38 (8%)    4/42 (10%)   | 
|FIRST INCIDENCE    |     729 (T)      711          729 (T)      669         |731 (T)      719          536          729          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.088      P=0.544N     P=0.343N     P=0.228     |P=0.443      P=0.245      P=0.395      P=0.326      | 
|POLY 3             |     P=0.069      P=0.498N     P=0.349N     P=0.214     |P=0.360      P=0.238      P=0.357      P=0.255      | 
|POLY 1.5           |     P=0.066      P=0.500N     P=0.353N     P=0.205     |P=0.330      P=0.232      P=0.349      P=0.234      | 
|POLY 6             |     P=0.075      P=0.496N     P=0.345N     P=0.229     |P=0.397      P=0.242      P=0.369      P=0.280      | 
|LOGISTIC REGRESSION|     P=0.074      P=0.509N     P=0.343N     P=0.213     |P=0.358      P=0.251      P=0.343      P=0.333      | 
|COCH-ARM / FISHERS |     P=0.062      P=0.500N     P=0.357N     P=0.194     |P=0.295      P=0.218      P=0.339      P=0.210      | 
|ORDER RESTRICTED   |     P=0.088      (e)          (e)          (e)         |P=0.256      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/49 (33%)  10/49 (20%)  8/49 (16%)   20/49 (41%) |6/50 (12%)   12/50 (24%)  8/50 (16%)   13/49 (27%)  | 
|POLY-3 RATE (b)    |     16/46.05     10/45.59     8/46.05      20/47.65    |6/42.71      12/45.04     8/44.68      13/46.90     | 
|POLY-3 PERCENT (g) |     34.7%        21.9%        17.4%        42.0%       |14.1%        26.7%        17.9%        27.7%        | 
|TERMINAL (d)       |     15/41 (37%)  9/38 (24%)   8/42 (19%)   17/43 (40%) |6/33 (18%)   11/35 (31%)  6/38 (16%)   11/42 (26%)  | 
|FIRST INCIDENCE    |     536          711          729 (T)      598         |731 (T)      719          536          697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.079      P=0.174N     P=0.042N*    P=0.332     |P=0.284      P=0.117      P=0.491      P=0.171      | 
|POLY 3             |     P=0.053      P=0.128N     P=0.046N*    P=0.306     |P=0.161      P=0.114      P=0.421      P=0.092      | 
|POLY 1.5           |     P=0.048 *    P=0.128N     P=0.047N*    P=0.286     |P=0.133      P=0.109      P=0.407      P=0.074      | 
|POLY 6             |     P=0.062      P=0.128N     P=0.044N*    P=0.339     |P=0.204      P=0.117      P=0.443      P=0.118      | 
|LOGISTIC REGRESSION|     P=0.056      P=0.121N     P=0.044N*    P=0.287     |P=0.205      P=0.127      P=0.413      P=0.155      | 
|COCH-ARM / FISHERS |     P=0.045 *    P=0.126N     P=0.049N*    P=0.265     |P=0.105      P=0.096      P=0.387      P=0.056      | 
|ORDER RESTRICTED   |     P=0.041 *    (e)          (e)          (e)         |P=0.088      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.69      0/45.94      0/46.42      0/47.18     |0/42.71      2/45.40      0/43.99      1/46.94      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.4%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/41 (0%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    1/35 (3%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          613          ---          729          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.661      P=0.251      (e)          P=0.553      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.647      P=0.251      (e)          P=0.519      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.634      P=0.247      (e)          P=0.510      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.663      P=0.254      (e)          P=0.529      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.616      P=0.221      (e)          P=0.546      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.617      P=0.247      (e)          P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.331      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/48 (6%)    0/50 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |                                                        |3/40.96      0/44.99      0/42.99      1/45.93      | 
|POLY-3 PERCENT (g) |                                                        |7.3%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |                                                        |3/33 (9%)    0/35 (0%)    0/37 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.414N     P=0.110N     P=0.101N     P=0.231N     | 
|POLY 3             |                                                        |P=0.475N     P=0.102N     P=0.110N     P=0.265N     | 
|POLY 1.5           |                                                        |P=0.477N     P=0.105N     P=0.112N     P=0.280N     | 
|POLY 6             |                                                        |P=0.469N     P=0.101N     P=0.107N     P=0.249N     | 
|LOGISTIC REGRESSION|                                                        |P=0.414N     (e)          (e)          P=0.231N     | 
|COCH-ARM / FISHERS |                                                        |P=0.473N     P=0.114N     P=0.117N     P=0.301N     | 
|ORDER RESTRICTED   |                                                        |P=0.027N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/47 (0%)    0/47 (0%)    0/46 (0%)   |8/47 (17%)   8/50 (16%)   1/49 (2%)    1/45 (2%)    | 
|POLY-3 RATE (b)    |     0/43.90      0/44.39      0/44.18      0/44.12     |8/40.43      8/45.23      1/42.99      1/42.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |19.8%        17.7%        2.3%         2.3%         | 
|TERMINAL (d)       |     0/40 (0%)    0/38 (0%)    0/41 (0%)    0/41 (0%)   |6/31 (19%)   6/35 (17%)   1/37 (3%)    1/38 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |596          693          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.004N**   P=0.511N     P=0.010N*    P=0.009N**   | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.005N**   P=0.511N     P=0.011N*    P=0.012N*    | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.006N**   P=0.523N     P=0.012N*    P=0.014N*    | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.004N**   P=0.506N     P=0.011N*    P=0.009N**   | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.006N**   P=0.499N     P=0.013N*    P=0.014N*    | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.009N**   P=0.554N     P=0.013N*    P=0.018N*    | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.006N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/46.30      1/46.06      1/46.42      0/47.18     |1/43.48      2/45.99      3/44.61      1/47.06      | 
|POLY-3 PERCENT (g) |     6.5%         2.2%         2.2%         0.0%        |2.3%         4.4%         6.7%         2.1%         | 
|TERMINAL (d)       |     2/41 (5%)    0/38 (0%)    1/42 (2%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    1/38 (3%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     536          697          729 (T)      ---         |450          506          564          697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.117N     P=0.317N     P=0.301N     P=0.118N    |P=0.453N     P=0.525      P=0.335      P=0.731N     | 
|POLY 3             |     P=0.120N     P=0.307N     P=0.304N     P=0.115N    |P=0.469N     P=0.520      P=0.314      P=0.743N     | 
|POLY 1.5           |     P=0.121N     P=0.307N     P=0.305N     P=0.117N    |P=0.485N     P=0.514      P=0.310      P=0.751N     | 
|POLY 6             |     P=0.118N     P=0.308N     P=0.304N     P=0.113N    |P=0.446N     P=0.525      P=0.322      P=0.731N     | 
|LOGISTIC REGRESSION|     P=0.129N     P=0.301N     P=0.316N     P=0.134N    |P=0.503N     P=0.230      P=0.284      P=0.750      | 
|COCH-ARM / FISHERS |     P=0.123N     P=0.309N     P=0.309N     P=0.121N    |P=0.500N     P=0.500      P=0.309      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.035N*    (e)          (e)          (e)         |P=0.446N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/46.30      1/46.06      1/46.42      0/47.18     |1/43.48      2/45.99      3/44.61      1/47.06      | 
|POLY-3 PERCENT (g) |     6.5%         2.2%         2.2%         0.0%        |2.3%         4.4%         6.7%         2.1%         | 
|TERMINAL (d)       |     2/41 (5%)    0/38 (0%)    1/42 (2%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    1/38 (3%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     536          697          729 (T)      ---         |450          506          564          697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.117N     P=0.317N     P=0.301N     P=0.118N    |P=0.453N     P=0.525      P=0.335      P=0.731N     | 
|POLY 3             |     P=0.120N     P=0.307N     P=0.304N     P=0.115N    |P=0.469N     P=0.520      P=0.314      P=0.743N     | 
|POLY 1.5           |     P=0.121N     P=0.307N     P=0.305N     P=0.117N    |P=0.485N     P=0.514      P=0.310      P=0.751N     | 
|POLY 6             |     P=0.118N     P=0.308N     P=0.304N     P=0.113N    |P=0.446N     P=0.525      P=0.322      P=0.731N     | 
|LOGISTIC REGRESSION|     P=0.129N     P=0.301N     P=0.316N     P=0.134N    |P=0.503N     P=0.230      P=0.284      P=0.750      | 
|COCH-ARM / FISHERS |     P=0.123N     P=0.309N     P=0.309N     P=0.121N    |P=0.500N     P=0.500      P=0.309      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.035N*    (e)          (e)          (e)         |P=0.446N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrous Histiocytoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.69      0/45.94      1/46.42      0/47.18     |0/42.71      0/44.99      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         2.2%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/41 (5%)    0/38 (0%)    1/42 (2%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.261N     P=0.255N     P=0.492N     P=0.228N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.271N     P=0.236N     P=0.495N     P=0.230N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.273N     P=0.237N     P=0.497N     P=0.233N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.268N     P=0.236N     P=0.492N     P=0.226N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.261N     (e)          P=0.492N     (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.276N     P=0.247N     P=0.500N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.070N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.30      1/46.06      0/46.42      0/47.18     |1/43.48      2/45.99      3/44.61      1/47.06      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         0.0%         0.0%        |2.3%         4.4%         6.7%         2.1%         | 
|TERMINAL (d)       |     0/41 (0%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    1/38 (3%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     536          697          ---          ---         |450          506          564          697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.321N     P=0.755N     P=0.500N     P=0.500N    |P=0.453N     P=0.525      P=0.335      P=0.731N     | 
|POLY 3             |     P=0.323N     P=0.759      P=0.499N     P=0.496N    |P=0.469N     P=0.520      P=0.314      P=0.743N     | 
|POLY 1.5           |     P=0.324N     P=0.760      P=0.500N     P=0.498N    |P=0.485N     P=0.514      P=0.310      P=0.751N     | 
|POLY 6             |     P=0.322N     P=0.759      P=0.499N     P=0.494N    |P=0.446N     P=0.525      P=0.322      P=0.731N     | 
|LOGISTIC REGRESSION|     P=0.358N     P=0.749N     P=0.566N     P=0.543N    |P=0.503N     P=0.230      P=0.284      P=0.750      | 
|COCH-ARM / FISHERS |     P=0.325N     P=0.753N     P=0.500N     P=0.500N    |P=0.500N     P=0.500      P=0.309      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.247N     (e)          (e)          (e)         |P=0.446N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/48 (4%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    3/50 (6%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/45.70      2/45.48      0/46.42      0/47.18     |0/41.88      3/45.27      0/43.50      0/46.76      | 
|POLY-3 PERCENT (g) |     2.2%         4.4%         0.0%         0.0%        |0.0%         6.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/41 (0%)    1/38 (3%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    2/35 (6%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     662          716          ---          ---         |---          656          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.217N     P=0.485      P=0.495N     P=0.487N    |P=0.240N     P=0.131      (e)          (e)          | 
|POLY 3             |     P=0.221N     P=0.498      P=0.497N     P=0.494N    |P=0.246N     P=0.133      (e)          (e)          | 
|POLY 1.5           |     P=0.222N     P=0.497      P=0.497N     P=0.495N    |P=0.257N     P=0.130      (e)          (e)          | 
|POLY 6             |     P=0.219N     P=0.498      P=0.497N     P=0.492N    |P=0.236N     P=0.135      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.223N     P=0.482      P=0.490N     P=0.496N    |P=0.269N     P=0.130      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.223N     P=0.492      P=0.495N     P=0.495N    |P=0.277N     P=0.125      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.161N     (e)          (e)          (e)         |P=0.158N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.69      1/45.94      1/46.42      2/47.63     |0/42.71      0/44.99      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         2.2%         4.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/41 (2%)    1/38 (3%)    1/42 (2%)    1/43 (2%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      598         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.389      P=0.745      P=0.756N     P=0.516     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.379      P=0.759N     P=0.757N     P=0.514     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.373      P=0.760N     P=0.758N     P=0.508     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.388      P=0.759N     P=0.756N     P=0.522     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.361      P=0.745      P=0.756N     P=0.483     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.364      P=0.753N     P=0.753N     P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.434      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     1/45.69      2/45.94      0/46.42      1/47.18     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         4.4%         0.0%         2.1%        |                                                    | 
|TERMINAL (d)       |     1/41 (2%)    2/38 (5%)    0/42 (0%)    1/43 (2%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.551N     P=0.473      P=0.495N     P=0.751N    |                                                    | 
|POLY 3             |     P=0.571N     P=0.502      P=0.497N     P=0.753N    |                                                    | 
|POLY 1.5           |     P=0.573N     P=0.501      P=0.498N     P=0.756N    |                                                    | 
|POLY 6             |     P=0.567N     P=0.502      P=0.495N     P=0.750N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.551N     P=0.473      (e)          P=0.751N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.577N     P=0.500      P=0.500N     P=0.753N    |                                                    | 
|ORDER RESTRICTED   |     P=0.370N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    3/50 (6%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |1/42.71      3/44.99      0/43.99      2/46.93      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         6.7%         0.0%         4.3%         | 
|TERMINAL (d)       |                                                        |1/33 (3%)    3/35 (9%)    0/38 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      731 (T)      ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.639N     P=0.326      P=0.472N     P=0.584      | 
|POLY 3             |                                                        |P=0.596      P=0.324      P=0.494N     P=0.533      | 
|POLY 1.5           |                                                        |P=0.581      P=0.319      P=0.497N     P=0.518      | 
|POLY 6             |                                                        |P=0.615      P=0.327      P=0.490N     P=0.551      | 
|LOGISTIC REGRESSION|                                                        |P=0.639N     P=0.326      (e)          P=0.584      | 
|COCH-ARM / FISHERS |                                                        |P=0.563      P=0.309      P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |                                                        |P=0.424N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/45.69      2/45.94      0/46.42      1/47.18     |1/42.80      0/44.99      0/43.99      1/46.93      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         2.1%        |2.3%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/41 (0%)    2/38 (5%)    0/42 (0%)    1/43 (2%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |709          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.636      P=0.222      (e)          P=0.510     |P=0.578      P=0.484N     P=0.474N     P=0.711N     | 
|POLY 3             |     P=0.626      P=0.238      (e)          P=0.506     |P=0.546      P=0.490N     P=0.495N     P=0.740N     | 
|POLY 1.5           |     P=0.622      P=0.238      (e)          P=0.504     |P=0.540      P=0.493N     P=0.497N     P=0.749N     | 
|POLY 6             |     P=0.631      P=0.238      (e)          P=0.510     |P=0.555      P=0.489N     P=0.491N     P=0.728N     | 
|LOGISTIC REGRESSION|     (e)          P=0.222      (e)          P=0.510     |P=0.558      P=0.491N     P=0.495N     P=0.741N     | 
|COCH-ARM / FISHERS |     P=0.617      P=0.247      (e)          P=0.500     |P=0.536      P=0.500N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.326      (e)          (e)          (e)         |P=0.376N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     6/46.36      2/45.99      0/46.42      0/47.18     |1/42.79      3/45.27      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     12.9%        4.4%         0.0%         0.0%        |2.3%         6.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/41 (10%)   1/38 (3%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    2/35 (6%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     609          716          ---          ---         |711          656          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.017N*    P=0.157N     P=0.018N*    P=0.017N*   |P=0.138N     P=0.330      P=0.468N     P=0.449N     | 
|POLY 3             |     P=0.016N*    P=0.136N     P=0.015N*    P=0.014N*   |P=0.149N     P=0.326      P=0.495N     P=0.482N     | 
|POLY 1.5           |     P=0.016N*    P=0.135N     P=0.015N*    P=0.015N*   |P=0.155N     P=0.320      P=0.497N     P=0.490N     | 
|POLY 6             |     P=0.015N*    P=0.138N     P=0.015N*    P=0.014N*   |P=0.141N     P=0.330      P=0.491N     P=0.471N     | 
|LOGISTIC REGRESSION|     P=0.019N*    P=0.134N     P=0.018N*    P=0.018N*   |P=0.159N     P=0.319      P=0.494N     P=0.488N     | 
|COCH-ARM / FISHERS |     P=0.019N*    P=0.134N     P=0.013N*    P=0.013N*   |P=0.166N     P=0.309      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P<0.001N**   (e)          (e)          (e)         |P=0.108N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    3/50 (6%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     6/46.36      4/45.99      0/46.42      1/47.18     |2/42.88      3/45.27      0/43.99      1/46.93      | 
|POLY-3 PERCENT (g) |     12.9%        8.7%         0.0%         2.1%        |4.7%         6.6%         0.0%         2.1%         | 
|TERMINAL (d)       |     4/41 (10%)   3/38 (8%)    0/42 (0%)    1/43 (2%)   |0/33 (0%)    2/35 (6%)    0/38 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     609          716          ---          729 (T)     |709          656          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.042N*    P=0.407N     P=0.018N*    P=0.055N    |P=0.259N     P=0.530      P=0.208N     P=0.420N     | 
|POLY 3             |     P=0.043N*    P=0.375N     P=0.015N*    P=0.053N    |P=0.296N     P=0.525      P=0.231N     P=0.469N     | 
|POLY 1.5           |     P=0.044N*    P=0.373N     P=0.015N*    P=0.055N    |P=0.306N     P=0.518      P=0.234N     P=0.483N     | 
|POLY 6             |     P=0.042N*    P=0.380N     P=0.015N*    P=0.052N    |P=0.284N     P=0.530      P=0.228N     P=0.452N     | 
|LOGISTIC REGRESSION|     P=0.046N*    P=0.368N     P=0.018N*    P=0.060N    |P=0.298N     P=0.519      P=0.231N     P=0.468N     | 
|COCH-ARM / FISHERS |     P=0.048N*    P=0.370N     P=0.013N*    P=0.056N    |P=0.316N     P=0.500      P=0.247N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.009N**   (e)          (e)          (e)         |P=0.178N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.69      0/45.94      0/46.42      1/47.63     |1/43.43      0/44.99      2/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         2.1%        |2.3%         0.0%         4.6%         0.0%         | 
|TERMINAL (d)       |     1/41 (2%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    2/38 (5%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          598         |479          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.548      P=0.515N     P=0.495N     P=0.750N    |P=0.404N     P=0.483N     P=0.538      P=0.496N     | 
|POLY 3             |     P=0.544      P=0.499N     P=0.497N     P=0.751N    |P=0.422N     P=0.493N     P=0.504      P=0.485N     | 
|POLY 1.5           |     P=0.540      P=0.500N     P=0.498N     P=0.755N    |P=0.433N     P=0.495N     P=0.502      P=0.492N     | 
|POLY 6             |     P=0.548      P=0.499N     P=0.495N     P=0.746N    |P=0.407N     P=0.492N     P=0.509      P=0.475N     | 
|LOGISTIC REGRESSION|     P=0.516      (e)          (e)          P=0.745     |P=0.447N     P=0.767N     P=0.490      P=0.489N     | 
|COCH-ARM / FISHERS |     P=0.536      P=0.500N     P=0.500N     P=0.753N    |P=0.441N     P=0.500N     P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.391N     (e)          (e)          (e)         |P=0.311N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |11/50 (22%)  10/50 (20%)  5/50 (10%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.69      0/45.94      1/46.42      1/47.18     |11/44.81     10/46.74     5/44.70      1/46.93      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.2%         2.1%        |24.6%        21.4%        11.2%        2.1%         | 
|TERMINAL (d)       |     1/41 (2%)    0/38 (0%)    1/42 (2%)    1/43 (2%)   |5/33 (15%)   5/35 (14%)   2/38 (5%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |386          550          550          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.580      P=0.515N     P=0.756N     P=0.751N    |P<0.001N**   P=0.448N     P=0.071N     P<0.001N**   | 
|POLY 3             |     P=0.569      P=0.499N     P=0.757N     P=0.753N    |P<0.001N**   P=0.456N     P=0.083N     P<0.001N**   | 
|POLY 1.5           |     P=0.565      P=0.500N     P=0.758N     P=0.756N    |P<0.001N**   P=0.468N     P=0.084N     P=0.002N**   | 
|POLY 6             |     P=0.574      P=0.499N     P=0.756N     P=0.750N    |P<0.001N**   P=0.450N     P=0.081N     P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.580      (e)          P=0.756N     P=0.751N    |P=0.002N**   P=0.554N     P=0.089N     P=0.003N**   | 
|COCH-ARM / FISHERS |     P=0.559      P=0.500N     P=0.753N     P=0.753N    |P=0.002N**   P=0.500N     P=0.086N     P=0.002N**   | 
|ORDER RESTRICTED   |     P=0.542      (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     35/50 (70%)  24/50 (48%)  21/50 (42%)  27/50 (54%) |28/50 (56%)  21/50 (42%)  14/50 (28%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |     35/47.30     24/47.58     21/47.55     27/47.81    |28/44.18     21/45.86     14/44.08     19/47.09     | 
|POLY-3 PERCENT (g) |     74.0%        50.4%        44.2%        56.5%       |63.4%        45.8%        31.8%        40.4%        | 
|TERMINAL (d)       |     32/41 (78%)  19/38 (50%)  18/42 (43%)  25/43 (58%) |22/33 (67%)  17/35 (49%)  13/38 (34%)  17/42 (41%)  | 
|FIRST INCIDENCE    |     456          543          526          598         |596          537          709          697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.182N     P=0.057N     P=0.004N**   P=0.041N*   |P=0.021N*    P=0.074N     P<0.001N**   P=0.005N**   | 
|POLY 3             |     P=0.279N     P=0.012N*    P=0.002N**   P=0.052N    |P=0.077N     P=0.066N     P=0.002N**   P=0.020N*    | 
|POLY 1.5           |     P=0.290N     P=0.015N*    P=0.002N**   P=0.061N    |P=0.100N     P=0.076N     P=0.002N**   P=0.031N*    | 
|POLY 6             |     P=0.261N     P=0.010N*    P<0.001N**   P=0.041N*   |P=0.054N     P=0.063N     P=0.002N**   P=0.013N*    | 
|LOGISTIC REGRESSION|     P=0.260N     P=0.019N*    P=0.003N**   P=0.047N*   |P=0.044N*    P=0.060N     P<0.001N**   P=0.012N*    | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.021N*    P=0.004N**   P=0.074N    |P=0.131N     P=0.115N     P=0.004N**   P=0.054N     | 
|ORDER RESTRICTED   |     P=0.011N*    (e)          (e)          (e)         |P=0.004N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/50 (52%)  21/50 (42%)  14/50 (28%)  23/50 (46%) |22/50 (44%)  29/50 (58%)  19/50 (38%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |     26/48.60     21/48.86     14/48.87     23/49.20    |22/47.00     29/49.13     19/46.60     13/47.07     | 
|POLY-3 PERCENT (g) |     53.5%        43.0%        28.7%        46.8%       |46.8%        59.0%        40.8%        27.6%        | 
|TERMINAL (d)       |     19/41 (46%)  11/38 (29%)  9/42 (21%)   18/43 (42%) |10/33 (30%)  18/35 (51%)  12/38 (32%)  11/42 (26%)  | 
|FIRST INCIDENCE    |     536          338          479          533         |386          506          501          697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.424N     P=0.309N     P=0.019N*    P=0.293N    |P=0.002N**   P=0.240      P=0.240N     P=0.016N*    | 
|POLY 3             |     P=0.520N     P=0.202N     P=0.009N**   P=0.322N    |P=0.004N**   P=0.158      P=0.352N     P=0.041N*    | 
|POLY 1.5           |     P=0.528N     P=0.204N     P=0.010N*    P=0.330N    |P=0.004N**   P=0.144      P=0.349N     P=0.044N*    | 
|POLY 6             |     P=0.511N     P=0.203N     P=0.010N*    P=0.314N    |P=0.003N**   P=0.169      P=0.352N     P=0.038N*    | 
|LOGISTIC REGRESSION|     P=0.500      P=0.215N     P=0.013N*    P=0.379N    |P=0.005N**   P=0.084      P=0.353N     P=0.048N*    | 
|COCH-ARM / FISHERS |     P=0.537N     P=0.212N     P=0.012N*    P=0.345N    |P=0.005N**   P=0.115      P=0.342N     P=0.046N*    | 
|ORDER RESTRICTED   |     P=0.084N     (e)          (e)          (e)         |P=0.007N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     43/50 (86%)  38/50 (76%)  29/50 (58%)  41/50 (82%) |40/50 (80%)  40/50 (80%)  26/50 (52%)  26/50 (52%)  | 
|POLY-3 RATE (b)    |     43/49.36     38/50.00     29/50.00     41/49.20    |40/47.46     40/50.00     26/46.60     26/47.10     | 
|POLY-3 PERCENT (g) |     87.1%        76.0%        58.0%        83.3%       |84.3%        80.0%        55.8%        55.2%        | 
|TERMINAL (d)       |     35/41 (85%)  26/38 (68%)  21/42 (50%)  36/43 (84%) |27/33 (82%)  25/35 (71%)  19/38 (50%)  23/42 (55%)  | 
|FIRST INCIDENCE    |     456          338          479          533         |386          506          501          697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.423N     P=0.377N     P=0.009N**   P=0.276N    |P<0.001N**   P=0.409N     P=0.003N**   P<0.001N**   | 
|POLY 3             |     P=0.409      P=0.120N     P<0.001N**   P=0.403N    |P<0.001N**   P=0.387N     P=0.002N**   P<0.001N**   | 
|POLY 1.5           |     P=0.421      P=0.132N     P<0.001N**   P=0.401N    |P<0.001N**   P=0.455N     P=0.002N**   P=0.002N**   | 
|POLY 6             |     P=0.400      P=0.110N     P<0.001N**   P=0.401N    |P<0.001N**   P=0.330N     P=0.002N**   P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.407      P=0.156N     P=0.002N**   P=0.374N    |P<0.001N**   P=0.577N     P=0.002N**   P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.450      P=0.154N     P=0.002N**   P=0.393N    |P<0.001N**   P=0.598N     P=0.003N**   P=0.003N**   | 
|ORDER RESTRICTED   |     P=0.033N*    (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.