National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/18915

TDMS Study 92013-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                4-METHYLIMIDAZOLE                                   DATE: 01/12/04       
EXPERIMENT: 92013 TEST: 06                                                                                     TIME: 14:42:31       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED FEED                                              NTP C#: 92013B       
PATHOLOGIST: HEATH, JAMES                                                                                      CAS: 822-36-6        
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                                                           FINAL #1 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                                4-METHYLIMIDAZOLE                                   DATE: 01/12/04       
EXPERIMENT: 92013 TEST: 06                                                                                     TIME: 14:42:31       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED FEED                                              NTP C#: 92013B       
PATHOLOGIST: HEATH, JAMES                                                                                      CAS: 822-36-6        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                   4-METHYLIMIDAZOLE                                                                              
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
Adrenal Cortex: Capsule                Hyperplasia                                                                                  
Islets, Pancreatic                     Hyperplasia                                                                                  
Liver                                  Eosinophilic Focus                                                                           
                                       Mixed Cell Focus                                                                             
Liver: Hepatocyte                      Vacuolization Cytoplasmic                                                                    
Lung                                   Infiltration Cellular Histiocyte                                                             
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lymph Node, Mesenteric                 Hemorrhage                                                                                   
Preputial Gland                        Cyst                                                                                         
Spleen: Lymphoid Follicle              Hyperplasia                                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Heart                                  Mineralization                                                                               
Intestine Small, Jejunum               Hyperplasia Lymphoid                                                                         
Liver                                  Cyst                                                                                         
                                       Hematopoietic Cell Proliferation                                                             
Lung                                   Infiltration Cellular Histiocyte                                                             
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lymph Node, Mandibular                 Hemorrhage                                                                                   
                                       Hyperplasia Lymphoid                                                                         
Lymph Node, Mesenteric                 Hyperplasia Lymphoid                                                                         
Mammary Gland                          Hyperplasia                                                                                  
Pancreas                               Cyst                                                                                         
Parathyroid Gland                      Cyst                                                                                         
Salivary Glands                        Atrophy                                                                                      
Stomach, Forestomach                   Diverticulum                                                                                 
Thyroid Gland: Follicle                Cyst                                                                                         
===============================================================                                                                     
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/50 (8%)    6/50 (12%)   8/50 (16%)  |9/50 (18%)   9/50 (18%)   9/50 (18%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     2/48.24      4/48.80      6/46.57      8/47.85     |9/47.07      9/47.90      9/48.22      5/46.05      | 
|POLY-3 PERCENT (g) |     4.2%         8.2%         12.9%        16.7%       |19.1%        18.8%        18.7%        10.9%        | 
|TERMINAL (d)       |     2/45 (4%)    3/44 (7%)    5/42 (12%)   8/46 (17%)  |8/43 (19%)   8/40 (20%)   7/43 (16%)   5/40 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      335          348          729 (T)     |593          702          684          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033 *    P=0.330      P=0.118      P=0.052     |P=0.177N     P=0.545      P=0.595N     P=0.233N     | 
|POLY 3             |     P=0.026 *    P=0.343      P=0.122      P=0.044 *   |P=0.162N     P=0.587N     P=0.581N     P=0.205N     | 
|POLY 1.5           |     P=0.026 *    P=0.342      P=0.127      P=0.045 *   |P=0.155N     P=0.585N     P=0.583N     P=0.197N     | 
|POLY 6             |     P=0.025 *    P=0.343      P=0.117      P=0.044 *   |P=0.172N     P=0.595N     P=0.581N     P=0.216N     | 
|LOGISTIC REGRESSION|     P=0.029 *    P=0.366      P=0.166      P=0.052     |P=0.158N     P=0.582N     P=0.583N     P=0.200N     | 
|COCH-ARM / FISHERS |     P=0.028 *    P=0.339      P=0.134      P=0.046 *   |P=0.148N     P=0.602N     P=0.602N     P=0.194N     | 
|ORDER RESTRICTED   |     P=0.029 *    (e)          (e)          (e)         |P=0.233N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/48.24      2/47.90      1/45.68      1/47.85     |0/46.61      0/47.80      1/48.01      2/46.05      | 
|POLY-3 PERCENT (g) |     6.2%         4.2%         2.2%         2.1%        |0.0%         0.0%         2.1%         4.3%         | 
|TERMINAL (d)       |     3/45 (7%)    2/44 (5%)    1/42 (2%)    1/46 (2%)   |0/43 (0%)    0/40 (0%)    1/43 (2%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.196N     P=0.510N     P=0.330N     P=0.298N    |P=0.065      (e)          P=0.500      P=0.223      | 
|POLY 3             |     P=0.204N     P=0.503N     P=0.325N     P=0.308N    |P=0.068      (e)          P=0.506      P=0.235      | 
|POLY 1.5           |     P=0.203N     P=0.502N     P=0.318N     P=0.308N    |P=0.069      (e)          P=0.505      P=0.237      | 
|POLY 6             |     P=0.205N     P=0.504N     P=0.333N     P=0.309N    |P=0.066      (e)          P=0.506      P=0.231      | 
|LOGISTIC REGRESSION|     P=0.196N     P=0.510N     P=0.330N     P=0.298N    |(e)          (e)          P=0.500      P=0.223      | 
|COCH-ARM / FISHERS |     P=0.199N     P=0.500N     P=0.309N     P=0.309N    |P=0.070      (e)          P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     P=0.223N     (e)          (e)          (e)         |P=0.073      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/50 (34%)  11/50 (22%)  10/50 (20%)  14/50 (28%) |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     17/48.24     11/48.10     10/45.68     14/48.73    |0/46.61      0/47.80      0/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     35.2%        22.9%        21.9%        28.7%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     17/45 (38%)  10/44 (23%)  10/42 (24%)  13/46 (28%) |0/43 (0%)    0/40 (0%)    0/43 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      676          729 (T)      355         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.348N     P=0.147N     P=0.121N     P=0.307N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.368N     P=0.132N     P=0.114N     P=0.320N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.368N     P=0.133N     P=0.103N     P=0.324N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.370N     P=0.131N     P=0.126N     P=0.318N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.384N     P=0.139N     P=0.121N     P=0.334N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.372N     P=0.133N     P=0.088N     P=0.333N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.181N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Capsule                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    5/50 (10%)  |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/48.24      1/47.90      2/45.68      5/47.85     |0/46.61      2/47.80      0/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         4.4%         10.5%       |0.0%         4.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/45 (2%)    1/44 (2%)    2/42 (5%)    5/46 (11%)  |0/43 (0%)    2/40 (5%)    0/43 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.032 *    P=0.757      P=0.476      P=0.109     |P=0.414N     P=0.223      (e)          (e)          | 
|POLY 3             |     P=0.027 *    P=0.759      P=0.481      P=0.100     |P=0.400N     P=0.243      (e)          (e)          | 
|POLY 1.5           |     P=0.027 *    P=0.759      P=0.488      P=0.101     |P=0.399N     P=0.243      (e)          (e)          | 
|POLY 6             |     P=0.027 *    P=0.758      P=0.474      P=0.100     |P=0.403N     P=0.242      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.032 *    P=0.757      P=0.476      P=0.109     |(e)          P=0.223      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.029 *    P=0.753N     P=0.500      P=0.102     |P=0.405N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.035 *    (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      0/45.68      0/47.85     |0/46.61      0/47.80      1/48.01      2/46.22      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.1%         4.3%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |0/43 (0%)    0/40 (0%)    1/43 (2%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.066      (e)          P=0.500      P=0.227      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.068      (e)          P=0.506      P=0.235      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.069      (e)          P=0.505      P=0.237      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.067      (e)          P=0.506      P=0.233      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.069      (e)          P=0.500      P=0.238      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.070      (e)          P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.073      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Hyperostosis                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |10/50 (20%)  12/50 (24%)  10/50 (20%)  6/50 (12%)   | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      0/45.68      0/47.85     |10/46.61     12/48.15     10/48.01     6/46.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |21.5%        24.9%        20.8%        13.0%        | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |10/43 (23%)  10/40 (25%)  10/43 (23%)  6/40 (15%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      668          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.148N     P=0.341      P=0.600      P=0.251N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.132N     P=0.438      P=0.570N     P=0.213N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.126N     P=0.433      P=0.574N     P=0.207N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.140N     P=0.440      P=0.569N     P=0.221N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.142N     P=0.423      P=0.600      P=0.251N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.123N     P=0.405      P=0.598N     P=0.207N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.175N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  15/50 (30%)  14/50 (28%)  15/50 (30%) |13/50 (26%)  13/50 (26%)  10/50 (20%)  17/50 (34%)  | 
|POLY-3 RATE (b)    |     13/48.95     15/49.04     14/49.40     15/48.52    |13/47.98     13/49.63     10/48.60     17/46.46     | 
|POLY-3 PERCENT (g) |     26.6%        30.6%        28.3%        30.9%       |27.1%        26.2%        20.6%        36.6%        | 
|TERMINAL (d)       |     11/45 (24%)  11/44 (25%)  7/42 (17%)   13/46 (28%) |9/43 (21%)   6/40 (15%)   9/43 (21%)   15/40 (38%)  | 
|FIRST INCIDENCE    |     513          586          348          628         |539          525          539          665          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.430      P=0.397      P=0.432      P=0.437     |P=0.188      P=0.539      P=0.321N     P=0.203      | 
|POLY 3             |     P=0.395      P=0.415      P=0.511      P=0.401     |P=0.181      P=0.551N     P=0.305N     P=0.221      | 
|POLY 1.5           |     P=0.398      P=0.411      P=0.507      P=0.403     |P=0.198      P=0.558N     P=0.303N     P=0.240      | 
|POLY 6             |     P=0.396      P=0.422      P=0.516      P=0.404     |P=0.163      P=0.546N     P=0.312N     P=0.199      | 
|LOGISTIC REGRESSION|     P=0.430      P=0.420      P=0.504N     P=0.414     |P=0.217      P=0.535      P=0.336N     P=0.255      | 
|COCH-ARM / FISHERS |     P=0.406      P=0.412      P=0.500      P=0.412     |P=0.216      P=0.590N     P=0.318N     P=0.257      | 
|ORDER RESTRICTED   |     P=0.503      (e)          (e)          (e)         |P=0.152      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/48.89      0/47.90      0/45.68      0/47.85     |0/46.61      2/48.27      1/48.01      2/46.42      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         0.0%        |0.0%         4.1%         2.1%         4.3%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |0/43 (0%)    0/40 (0%)    1/43 (2%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     513          ---          ---          ---         |---          632          729 (T)      647          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.307N     P=0.500N     P=0.504N     P=0.500N    |P=0.237      P=0.247      P=0.500      P=0.235      | 
|POLY 3             |     P=0.306N     P=0.504N     P=0.514N     P=0.504N    |P=0.245      P=0.245      P=0.506      P=0.236      | 
|POLY 1.5           |     P=0.306N     P=0.503N     P=0.509N     P=0.503N    |P=0.247      P=0.244      P=0.505      P=0.238      | 
|POLY 6             |     P=0.306N     P=0.506N     P=0.519N     P=0.506N    |P=0.242      P=0.246      P=0.506      P=0.234      | 
|LOGISTIC REGRESSION|     P=0.244N     P=0.375N     P=0.312N     P=0.377N    |P=0.240      P=0.199      P=0.500      P=0.232      | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.246      P=0.247      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     P=0.124N     (e)          (e)          (e)         |P=0.155      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    3/49 (6%)    5/50 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |1/46.61      3/46.84      5/48.52      3/46.05      | 
|POLY-3 PERCENT (g) |                                                        |2.2%         6.4%         10.3%        6.5%         | 
|TERMINAL (d)       |                                                        |1/43 (2%)    2/40 (5%)    3/43 (7%)    3/40 (8%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      721          635          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.255      P=0.284      P=0.112      P=0.280      | 
|POLY 3             |                                                        |P=0.266      P=0.307      P=0.111      P=0.301      | 
|POLY 1.5           |                                                        |P=0.273      P=0.307      P=0.109      P=0.305      | 
|POLY 6             |                                                        |P=0.257      P=0.305      P=0.114      P=0.296      | 
|LOGISTIC REGRESSION|                                                        |P=0.272      P=0.296      P=0.099      P=0.280      | 
|COCH-ARM / FISHERS |                                                        |P=0.276      P=0.301      P=0.102      P=0.309      | 
|ORDER RESTRICTED   |                                                        |P=0.168      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/48.29      0/47.90      0/45.68      2/47.85     |0/46.61      0/47.80      2/48.01      1/46.05      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         4.2%        |0.0%         0.0%         4.2%         2.2%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    2/46 (4%)   |0/43 (0%)    0/40 (0%)    2/43 (5%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     715          ---          ---          729 (T)     |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.252      P=0.500N     P=0.518N     P=0.505     |P=0.235      (e)          P=0.238      P=0.486      | 
|POLY 3             |     P=0.244      P=0.502N     P=0.511N     P=0.497     |P=0.237      (e)          P=0.244      P=0.498      | 
|POLY 1.5           |     P=0.244      P=0.501N     P=0.507N     P=0.498     |P=0.241      (e)          P=0.243      P=0.500      | 
|POLY 6             |     P=0.243      P=0.502N     P=0.515N     P=0.496     |P=0.231      (e)          P=0.244      P=0.495      | 
|LOGISTIC REGRESSION|     P=0.244      P=0.500N     P=0.506N     P=0.497     |(e)          (e)          P=0.238      P=0.486      | 
|COCH-ARM / FISHERS |     P=0.246      P=0.500N     P=0.500N     P=0.500     |P=0.246      (e)          P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.131      (e)          (e)          (e)         |P=0.173      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    3/50 (6%)   |2/50 (4%)    3/50 (6%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/48.24      1/47.90      1/45.68      3/48.21     |2/46.61      3/47.80      2/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         2.2%         6.2%        |4.3%         6.3%         4.2%         0.0%         | 
|TERMINAL (d)       |     1/45 (2%)    1/44 (2%)    1/42 (2%)    2/46 (4%)   |2/43 (5%)    3/40 (8%)    2/43 (5%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      628         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.172      P=0.757      P=0.746      P=0.313     |P=0.144N     P=0.467      P=0.695      P=0.254N     | 
|POLY 3             |     P=0.163      P=0.759      P=0.748      P=0.305     |P=0.138N     P=0.511      P=0.683N     P=0.240N     | 
|POLY 1.5           |     P=0.163      P=0.759      P=0.753      P=0.305     |P=0.135N     P=0.511      P=0.685N     P=0.238N     | 
|POLY 6             |     P=0.164      P=0.758      P=0.744      P=0.307     |P=0.141N     P=0.509      P=0.683N     P=0.243N     | 
|LOGISTIC REGRESSION|     P=0.163      P=0.757      P=0.746      P=0.310     |P=0.144N     P=0.467      P=0.695      (e)          | 
|COCH-ARM / FISHERS |     P=0.163      P=0.753N     P=0.753N     P=0.309     |P=0.134N     P=0.500      P=0.691N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.189      (e)          (e)          (e)         |P=0.141N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/48.24      0/47.90      2/45.68      1/47.85     |1/46.61      0/47.80      1/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         4.4%         2.1%        |2.2%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     2/45 (4%)    0/44 (0%)    2/42 (5%)    1/46 (2%)   |1/43 (2%)    0/40 (0%)    1/43 (2%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.523N     P=0.243N     P=0.670      P=0.492N    |P=0.415N     P=0.514N     P=0.762      P=0.514N     | 
|POLY 3             |     P=0.533N     P=0.239N     P=0.674      P=0.503N    |P=0.410N     P=0.495N     P=0.754N     P=0.502N     | 
|POLY 1.5           |     P=0.532N     P=0.239N     P=0.681      P=0.502N    |P=0.409N     P=0.495N     P=0.755N     P=0.500N     | 
|POLY 6             |     P=0.533N     P=0.239N     P=0.667      P=0.503N    |P=0.412N     P=0.496N     P=0.754N     P=0.505N     | 
|LOGISTIC REGRESSION|     P=0.523N     (e)          P=0.670      P=0.492N    |P=0.415N     (e)          P=0.762      (e)          | 
|COCH-ARM / FISHERS |     P=0.531N     P=0.247N     P=0.691N     P=0.500N    |P=0.405N     P=0.500N     P=0.753N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.418N     (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      2/46.66      0/47.85     |0/46.61      0/47.80      0/48.01      4/47.24      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         0.0%        |0.0%         0.0%         0.0%         8.5%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |0/43 (0%)    0/40 (0%)    0/43 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          522          ---         |---          ---          ---          409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.593      (e)          P=0.230      (e)         |P=0.003 **   (e)          (e)          P=0.064      | 
|POLY 3             |     P=0.594      (e)          P=0.230      (e)         |P=0.003 **   (e)          (e)          P=0.062      | 
|POLY 1.5           |     P=0.594      (e)          P=0.232      (e)         |P=0.003 **   (e)          (e)          P=0.062      | 
|POLY 6             |     P=0.594      (e)          P=0.228      (e)         |P=0.003 **   (e)          (e)          P=0.061      | 
|LOGISTIC REGRESSION|     P=0.643      (e)          P=0.350      (e)         |P=0.002 **   (e)          (e)          P=0.045 *    | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.003 **   (e)          (e)          P=0.059      | 
|ORDER RESTRICTED   |     P=0.241      (e)          (e)          (e)         |P=0.002 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/49 (2%)    3/47 (6%)    4/50 (8%)   |3/49 (6%)    4/48 (8%)    2/46 (4%)    2/46 (4%)    | 
|POLY-3 RATE (b)    |     3/48.24      1/47.38      3/43.85      4/47.85     |3/46.61      4/46.78      2/44.63      2/42.28      | 
|POLY-3 PERCENT (g) |     6.2%         2.1%         6.8%         8.4%        |6.4%         8.6%         4.5%         4.7%         | 
|TERMINAL (d)       |     3/45 (7%)    1/44 (2%)    3/42 (7%)    4/46 (9%)   |3/43 (7%)    3/40 (8%)    2/41 (5%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      525          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.294      P=0.314N     P=0.631      P=0.512     |P=0.364N     P=0.468      P=0.522N     P=0.556N     | 
|POLY 3             |     P=0.279      P=0.312N     P=0.617      P=0.496     |P=0.363N     P=0.502      P=0.520N     P=0.544N     | 
|POLY 1.5           |     P=0.281      P=0.313N     P=0.622      P=0.497     |P=0.359N     P=0.497      P=0.523N     P=0.539N     | 
|POLY 6             |     P=0.278      P=0.311N     P=0.614      P=0.495     |P=0.368N     P=0.505      P=0.517N     P=0.550N     | 
|LOGISTIC REGRESSION|     P=0.294      P=0.314N     P=0.631      P=0.512     |P=0.339N     P=0.462      P=0.522N     P=0.556N     | 
|COCH-ARM / FISHERS |     P=0.284      P=0.316N     P=0.631      P=0.500     |P=0.348N     P=0.488      P=0.530N     P=0.530N     | 
|ORDER RESTRICTED   |     P=0.301      (e)          (e)          (e)         |P=0.455N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum                                                                                                         | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    2/47 (4%)    3/48 (6%)    1/50 (2%)   |4/50 (8%)    2/48 (4%)    2/47 (4%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     2/46.29      2/46.49      3/44.48      1/47.85     |4/46.61      2/45.93      2/45.13      0/43.28      | 
|POLY-3 PERCENT (g) |     4.3%         4.3%         6.8%         2.1%        |8.6%         4.4%         4.4%         0.0%         | 
|TERMINAL (d)       |     2/44 (5%)    2/44 (5%)    3/42 (7%)    1/46 (2%)   |4/43 (9%)    2/40 (5%)    2/42 (5%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.388N     P=0.695      P=0.479      P=0.484N    |P=0.051N     P=0.371N     P=0.348N     P=0.076N     | 
|POLY 3             |     P=0.393N     P=0.692N     P=0.482      P=0.489N    |P=0.051N     P=0.344N     P=0.352N     P=0.070N     | 
|POLY 1.5           |     P=0.391N     P=0.692      P=0.488      P=0.488N    |P=0.051N     P=0.345N     P=0.355N     P=0.069N     | 
|POLY 6             |     P=0.396N     P=0.690N     P=0.476      P=0.489N    |P=0.052N     P=0.346N     P=0.351N     P=0.072N     | 
|LOGISTIC REGRESSION|     P=0.388N     P=0.695      P=0.479      P=0.484N    |P=0.051N     P=0.371N     P=0.348N     (e)          | 
|COCH-ARM / FISHERS |     P=0.384N     P=0.684      P=0.500      P=0.485N    |P=0.050N     P=0.359N     P=0.369N     P=0.066N     | 
|ORDER RESTRICTED   |     P=0.374N     (e)          (e)          (e)         |P=0.033N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    2/49 (4%)    0/50 (0%)    1/50 (2%)   |1/49 (2%)    0/48 (0%)    0/47 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     4/47.37      2/47.38      0/45.68      1/47.85     |1/46.61      0/46.15      0/45.13      2/45.05      | 
|POLY-3 PERCENT (g) |     8.4%         4.2%         0.0%         2.1%        |2.2%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     4/45 (9%)    2/44 (5%)    0/42 (0%)    1/46 (2%)   |1/43 (2%)    0/40 (0%)    0/42 (0%)    2/39 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.085N     P=0.348N     P=0.072N     P=0.174N    |P=0.229      P=0.514N     P=0.505N     P=0.466      | 
|POLY 3             |     P=0.084N     P=0.337N     P=0.065N     P=0.176N    |P=0.242      P=0.502N     P=0.506N     P=0.488      | 
|POLY 1.5           |     P=0.083N     P=0.338N     P=0.062N     P=0.175N    |P=0.244      P=0.503N     P=0.507N     P=0.493      | 
|POLY 6             |     P=0.086N     P=0.337N     P=0.068N     P=0.177N    |P=0.241      P=0.502N     P=0.506N     P=0.483      | 
|LOGISTIC REGRESSION|     P=0.085N     P=0.348N     (e)          P=0.174N    |P=0.229      (e)          (e)          P=0.466      | 
|COCH-ARM / FISHERS |     P=0.083N     P=0.339N     P=0.056N     P=0.175N    |P=0.247      P=0.505N     P=0.510N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.038N*    (e)          (e)          (e)         |P=0.124      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  12/50 (24%)  12/50 (24%)  7/50 (14%)  |1/49 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     13/48.24     12/48.10     12/45.84     7/47.85     |1/46.61      1/47.80      0/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     27.0%        25.0%        26.2%        14.6%       |2.2%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     13/45 (29%)  11/44 (25%)  11/42 (26%)  7/46 (15%)  |1/43 (2%)    1/40 (3%)    0/43 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      676          686          729 (T)     |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.077N     P=0.526N     P=0.580N     P=0.094N    |P=0.243N     P=0.746      P=0.500N     P=0.514N     | 
|POLY 3             |     P=0.087N     P=0.503N     P=0.559N     P=0.107N    |P=0.234N     P=0.755N     P=0.494N     P=0.502N     | 
|POLY 1.5           |     P=0.086N     P=0.504N     P=0.538N     P=0.107N    |P=0.234N     P=0.755N     P=0.495N     P=0.500N     | 
|POLY 6             |     P=0.088N     P=0.502N     P=0.578N     P=0.108N    |P=0.234N     P=0.756N     P=0.494N     P=0.505N     | 
|LOGISTIC REGRESSION|     P=0.090N     P=0.513N     P=0.585      P=0.094N    |P=0.243N     P=0.746      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.083N     P=0.500N     P=0.500N     P=0.105N    |P=0.233N     P=0.747N     P=0.495N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.114N     (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |1/49 (2%)    2/50 (4%)    6/50 (12%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/48.24      2/47.90      0/45.68      2/47.85     |1/46.61      2/47.80      6/48.01      3/46.46      | 
|POLY-3 PERCENT (g) |     4.2%         4.2%         0.0%         4.2%        |2.2%         4.2%         12.5%        6.5%         | 
|TERMINAL (d)       |     2/45 (4%)    2/44 (5%)    0/42 (0%)    2/46 (4%)   |1/43 (2%)    1/40 (3%)    6/43 (14%)   1/40 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |729 (T)      727          729 (T)      665          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.546N     P=0.686      P=0.254N     P=0.687N    |P=0.194      P=0.478      P=0.058      P=0.289      | 
|POLY 3             |     P=0.561N     P=0.691      P=0.250N     P=0.691     |P=0.200      P=0.509      P=0.061      P=0.304      | 
|POLY 1.5           |     P=0.559N     P=0.692      P=0.245N     P=0.691     |P=0.205      P=0.509      P=0.061      P=0.307      | 
|POLY 6             |     P=0.563N     P=0.690      P=0.254N     P=0.690     |P=0.197      P=0.507      P=0.061      P=0.302      | 
|LOGISTIC REGRESSION|     P=0.546N     P=0.686      (e)          P=0.687N    |P=0.203      P=0.491      P=0.058      P=0.319      | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.691N     P=0.247N     P=0.691N    |P=0.216      P=0.508      P=0.059      P=0.316      | 
|ORDER RESTRICTED   |     P=0.451N     (e)          (e)          (e)         |P=0.111      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    0/50 (0%)    2/50 (4%)   |1/49 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/48.24      3/47.90      0/45.68      2/47.85     |1/46.61      1/47.80      0/48.01      1/46.05      | 
|POLY-3 PERCENT (g) |     4.2%         6.3%         0.0%         4.2%        |2.2%         2.1%         0.0%         2.2%         | 
|TERMINAL (d)       |     2/45 (4%)    3/44 (7%)    0/42 (0%)    2/46 (4%)   |1/43 (2%)    1/40 (3%)    0/43 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.465N     P=0.490      P=0.254N     P=0.687N    |P=0.629N     P=0.746      P=0.500N     P=0.746      | 
|POLY 3             |     P=0.481N     P=0.497      P=0.250N     P=0.691     |P=0.613N     P=0.755N     P=0.494N     P=0.758      | 
|POLY 1.5           |     P=0.479N     P=0.498      P=0.245N     P=0.691     |P=0.612N     P=0.755N     P=0.495N     P=0.760      | 
|POLY 6             |     P=0.483N     P=0.496      P=0.254N     P=0.690     |P=0.613N     P=0.756N     P=0.494N     P=0.755      | 
|LOGISTIC REGRESSION|     P=0.465N     P=0.490      (e)          P=0.687N    |P=0.629N     P=0.746      (e)          P=0.746      | 
|COCH-ARM / FISHERS |     P=0.474N     P=0.500      P=0.247N     P=0.691N    |P=0.612N     P=0.747N     P=0.495N     P=0.747N     | 
|ORDER RESTRICTED   |     P=0.337N     (e)          (e)          (e)         |P=0.535N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      2/46.19      0/47.85     |0/46.61      0/47.80      0/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |0/43 (0%)    0/40 (0%)    0/43 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          632          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.588      (e)          P=0.221      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.595      (e)          P=0.228      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.595      (e)          P=0.231      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.595      (e)          P=0.225      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.611      (e)          P=0.276      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.239      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/50 (68%)  40/50 (80%)  38/50 (76%)  35/50 (70%) |21/49 (43%)  20/50 (40%)  17/50 (34%)  25/50 (50%)  | 
|POLY-3 RATE (b)    |     34/49.05     40/49.06     38/47.00     35/48.21    |21/47.38     20/49.07     17/48.34     25/49.53     | 
|POLY-3 PERCENT (g) |     69.3%        81.5%        80.9%        72.6%       |44.3%        40.8%        35.2%        50.5%        | 
|TERMINAL (d)       |     32/45 (71%)  37/44 (84%)  35/42 (83%)  34/46 (74%) |18/43 (42%)  14/40 (35%)  16/43 (37%)  17/40 (43%)  | 
|FIRST INCIDENCE    |     459          335          441          628         |539          525          635          409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.418N     P=0.101      P=0.114      P=0.562     |P=0.190      P=0.558      P=0.270N     P=0.217      | 
|POLY 3             |     P=0.518      P=0.117      P=0.137      P=0.447     |P=0.270      P=0.441N     P=0.240N     P=0.344      | 
|POLY 1.5           |     P=0.540      P=0.122      P=0.173      P=0.461     |P=0.261      P=0.450N     P=0.241N     P=0.329      | 
|POLY 6             |     P=0.507      P=0.111      P=0.109      P=0.441     |P=0.280      P=0.437N     P=0.242N     P=0.358      | 
|LOGISTIC REGRESSION|     P=0.524N     P=0.120      P=0.146      P=0.478     |P=0.286      P=0.469N     P=0.232N     P=0.351      | 
|COCH-ARM / FISHERS |     P=0.489N     P=0.127      P=0.252      P=0.500     |P=0.247      P=0.466N     P=0.242N     P=0.305      | 
|ORDER RESTRICTED   |     P=0.226      (e)          (e)          (e)         |P=0.238      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/49 (6%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      0/45.68      0/47.85     |3/46.61      2/48.78      1/48.01      2/46.12      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.4%         4.1%         2.1%         4.3%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |3/43 (7%)    0/40 (0%)    1/43 (2%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      525          729 (T)      711          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.420N     P=0.510N     P=0.305N     P=0.530N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.408N     P=0.479N     P=0.295N     P=0.505N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.404N     P=0.483N     P=0.296N     P=0.500N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.412N     P=0.477N     P=0.294N     P=0.511N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.343N     P=0.557N     P=0.305N     P=0.517N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.397N     P=0.490N     P=0.301N     P=0.490N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.354N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      0/45.68      0/47.85     |0/46.61      0/47.80      2/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |0/43 (0%)    0/40 (0%)    2/43 (5%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.585      (e)          P=0.238      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.582      (e)          P=0.244      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.589      (e)          P=0.243      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.574      (e)          P=0.244      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.238      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.595      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.254      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/48.24      3/47.90      2/45.68      3/47.85     |0/46.61      0/47.80      0/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     6.2%         6.3%         4.4%         6.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/45 (7%)    3/44 (7%)    2/42 (5%)    3/46 (7%)   |0/43 (0%)    0/40 (0%)    0/43 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.550N     P=0.652      P=0.531N     P=0.653N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.569N     P=0.659      P=0.525N     P=0.658     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.567N     P=0.659      P=0.516N     P=0.659     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.571N     P=0.658      P=0.534N     P=0.658     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.550N     P=0.652      P=0.531N     P=0.653N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.562N     P=0.661N     P=0.500N     P=0.661N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.656N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/48.24      1/47.90      0/45.68      1/47.85     |3/46.61      0/47.80      0/48.01      1/46.05      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         2.1%        |6.4%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/45 (0%)    1/44 (2%)    0/42 (0%)    1/46 (2%)   |3/43 (7%)    0/40 (0%)    0/43 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.411      P=0.496      (e)          P=0.504     |P=0.258N     P=0.134N     P=0.121N     P=0.331N     | 
|POLY 3             |     P=0.402      P=0.499      (e)          P=0.498     |P=0.248N     P=0.114N     P=0.114N     P=0.310N     | 
|POLY 1.5           |     P=0.403      P=0.499      (e)          P=0.499     |P=0.249N     P=0.115N     P=0.115N     P=0.306N     | 
|POLY 6             |     P=0.401      P=0.498      (e)          P=0.498     |P=0.247N     P=0.115N     P=0.113N     P=0.315N     | 
|LOGISTIC REGRESSION|     (e)          P=0.496      (e)          P=0.504     |P=0.258N     (e)          (e)          P=0.331N     | 
|COCH-ARM / FISHERS |     P=0.405      P=0.500      (e)          P=0.500     |P=0.248N     P=0.121N     P=0.121N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.250      (e)          (e)          (e)         |P=0.038N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/48.24      2/48.10      1/45.68      1/47.85     |1/46.61      2/47.80      1/48.18      0/46.05      | 
|POLY-3 PERCENT (g) |     10.4%        4.2%         2.2%         2.1%        |2.2%         4.2%         2.1%         0.0%         | 
|TERMINAL (d)       |     5/45 (11%)   1/44 (2%)    1/42 (2%)    1/46 (2%)   |1/43 (2%)    2/40 (5%)    0/43 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      676          729 (T)      729 (T)     |729 (T)      729 (T)      685          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.061N     P=0.228N     P=0.120N     P=0.099N    |P=0.258N     P=0.475      P=0.758N     P=0.514N     | 
|POLY 3             |     P=0.061N     P=0.218N     P=0.115N     P=0.104N    |P=0.250N     P=0.509      P=0.753N     P=0.502N     | 
|POLY 1.5           |     P=0.060N     P=0.218N     P=0.110N     P=0.103N    |P=0.248N     P=0.508      P=0.754N     P=0.500N     | 
|POLY 6             |     P=0.062N     P=0.217N     P=0.120N     P=0.104N    |P=0.253N     P=0.507      P=0.752N     P=0.505N     | 
|LOGISTIC REGRESSION|     P=0.063N     P=0.218N     P=0.120N     P=0.099N    |P=0.248N     P=0.475      P=0.762      (e)          | 
|COCH-ARM / FISHERS |     P=0.060N     P=0.218N     P=0.102N     P=0.102N    |P=0.247N     P=0.500      P=0.753N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.037N*    (e)          (e)          (e)         |P=0.234N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |6/50 (12%)   0/50 (0%)    5/50 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      0/45.68      0/47.85     |6/47.21      0/47.80      5/48.60      3/46.22      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |12.7%        0.0%         10.3%        6.5%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |5/43 (12%)   0/40 (0%)    4/43 (9%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |539          ---          539          685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.415N     P=0.022N*    P=0.497N     P=0.278N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.403N     P=0.015N*    P=0.480N     P=0.253N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.397N     P=0.015N*    P=0.483N     P=0.246N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.407N     P=0.015N*    P=0.479N     P=0.261N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.392N     P=0.018N*    P=0.531N     P=0.242N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.390N     P=0.013N*    P=0.500N     P=0.243N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.147N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    3/50 (6%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      0/45.68      1/47.85     |2/46.61      3/47.80      1/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.1%        |4.3%         6.3%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    1/46 (2%)   |2/43 (5%)    3/40 (8%)    1/43 (2%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.205      (e)          (e)          P=0.504     |P=0.111N     P=0.467      P=0.500N     P=0.254N     | 
|POLY 3             |     P=0.198      (e)          (e)          P=0.498     |P=0.105N     P=0.511      P=0.490N     P=0.240N     | 
|POLY 1.5           |     P=0.198      (e)          (e)          P=0.499     |P=0.103N     P=0.511      P=0.491N     P=0.238N     | 
|POLY 6             |     P=0.198      (e)          (e)          P=0.498     |P=0.107N     P=0.509      P=0.489N     P=0.243N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.504     |P=0.111N     P=0.467      P=0.500N     (e)          | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.104N     P=0.500      P=0.500N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.119      (e)          (e)          (e)         |P=0.114N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    3/50 (6%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      3/45.68      1/47.85     |1/46.61      3/47.80      1/48.01      1/46.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         6.6%         2.1%        |2.2%         6.3%         2.1%         2.2%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    3/42 (7%)    1/46 (2%)   |1/43 (2%)    3/40 (8%)    1/43 (2%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.256      (e)          P=0.109      P=0.504     |P=0.462N     P=0.280      P=0.762      P=0.746      | 
|POLY 3             |     P=0.245      (e)          P=0.109      P=0.498     |P=0.446N     P=0.315      P=0.754N     P=0.758      | 
|POLY 1.5           |     P=0.245      (e)          P=0.113      P=0.499     |P=0.443N     P=0.314      P=0.755N     P=0.760      | 
|POLY 6             |     P=0.245      (e)          P=0.106      P=0.498     |P=0.451N     P=0.313      P=0.754N     P=0.755      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.109      P=0.504     |P=0.462N     P=0.280      P=0.762      P=0.746      | 
|COCH-ARM / FISHERS |     P=0.247      (e)          P=0.121      P=0.500     |P=0.444N     P=0.309      P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.106      (e)          (e)          (e)         |P=0.449N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    7/50 (14%)   2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/48.24      7/47.90      2/45.68      0/47.85     |1/46.61      0/47.80      1/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     6.2%         14.6%        4.4%         0.0%        |2.2%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     3/45 (7%)    7/44 (16%)   2/42 (5%)    0/46 (0%)   |1/43 (2%)    0/40 (0%)    1/43 (2%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.034N*    P=0.149      P=0.531N     P=0.118N    |P=0.415N     P=0.514N     P=0.762      P=0.514N     | 
|POLY 3             |     P=0.035N*    P=0.155      P=0.525N     P=0.120N    |P=0.410N     P=0.495N     P=0.754N     P=0.502N     | 
|POLY 1.5           |     P=0.034N*    P=0.156      P=0.516N     P=0.120N    |P=0.409N     P=0.495N     P=0.755N     P=0.500N     | 
|POLY 6             |     P=0.035N*    P=0.154      P=0.534N     P=0.121N    |P=0.412N     P=0.496N     P=0.754N     P=0.505N     | 
|LOGISTIC REGRESSION|     P=0.034N*    P=0.149      P=0.531N     (e)         |P=0.415N     (e)          P=0.762      (e)          | 
|COCH-ARM / FISHERS |     P=0.035N*    P=0.159      P=0.500N     P=0.121N    |P=0.405N     P=0.500N     P=0.753N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.022N*    (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    2/50 (4%)    0/50 (0%)   |4/50 (8%)    3/50 (6%)    2/50 (4%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     2/49.12      3/47.90      2/45.68      0/47.85     |4/46.70      3/48.42      2/48.01      6/46.74      | 
|POLY-3 PERCENT (g) |     4.1%         6.3%         4.4%         0.0%        |8.6%         6.2%         4.2%         12.8%        | 
|TERMINAL (d)       |     0/45 (0%)    3/44 (7%)    2/42 (5%)    0/46 (0%)   |3/43 (7%)    2/40 (5%)    2/43 (5%)    3/40 (8%)    | 
|FIRST INCIDENCE    |     459          729 (T)      729 (T)      ---         |707          525          729 (T)      640          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.137N     P=0.490      P=0.666      P=0.244N    |P=0.232      P=0.530N     P=0.337N     P=0.342      | 
|POLY 3             |     P=0.142N     P=0.489      P=0.667      P=0.243N    |P=0.244      P=0.480N     P=0.325N     P=0.370      | 
|POLY 1.5           |     P=0.140N     P=0.492      P=0.677      P=0.241N    |P=0.247      P=0.484N     P=0.327N     P=0.373      | 
|POLY 6             |     P=0.145N     P=0.484      P=0.657      P=0.245N    |P=0.242      P=0.481N     P=0.325N     P=0.367      | 
|LOGISTIC REGRESSION|     P=0.124N     P=0.533      P=0.618N     P=0.156N    |P=0.248      P=0.520N     P=0.323N     P=0.369      | 
|COCH-ARM / FISHERS |     P=0.134N     P=0.500      P=0.691N     P=0.247N    |P=0.248      P=0.500N     P=0.339N     P=0.370      | 
|ORDER RESTRICTED   |     P=0.135N     (e)          (e)          (e)         |P=0.191      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   2/50 (4%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/48.24      5/47.90      2/45.68      0/47.85     |1/46.70      1/47.90      1/48.18      1/46.87      | 
|POLY-3 PERCENT (g) |     8.3%         10.4%        4.4%         0.0%        |2.1%         2.1%         2.1%         2.1%         | 
|TERMINAL (d)       |     4/45 (9%)    5/44 (11%)   2/42 (5%)    0/46 (0%)   |0/43 (0%)    0/40 (0%)    0/43 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |707          702          684          409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.026N*    P=0.486      P=0.369N     P=0.061N    |P=0.622      P=0.753      P=0.753N     P=0.755      | 
|POLY 3             |     P=0.027N*    P=0.496      P=0.363N     P=0.062N    |P=0.632      P=0.755N     P=0.753N     P=0.760N     | 
|POLY 1.5           |     P=0.026N*    P=0.497      P=0.354N     P=0.061N    |P=0.631N     P=0.755N     P=0.755N     P=0.758N     | 
|POLY 6             |     P=0.027N*    P=0.494      P=0.373N     P=0.062N    |P=0.628      P=0.756N     P=0.753N     P=0.759      | 
|LOGISTIC REGRESSION|     P=0.026N*    P=0.486      P=0.369N     (e)         |P=0.581      P=0.761      P=0.756      P=0.713      | 
|COCH-ARM / FISHERS |     P=0.026N*    P=0.500      P=0.339N     P=0.059N    |P=0.634      P=0.753N     P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.032N*    (e)          (e)          (e)         |P=0.741N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Kupffer Cell                                                                                                              | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      0/45.68      0/47.85     |1/47.17      1/47.83      2/48.34      0/46.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.1%         2.1%         4.1%         0.0%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |0/43 (0%)    0/40 (0%)    1/43 (2%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |555          721          635          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.375N     P=0.758N     P=0.510      P=0.500N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.377N     P=0.757N     P=0.509      P=0.505N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.371N     P=0.757N     P=0.508      P=0.502N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.383N     P=0.760N     P=0.509      P=0.509N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.392N     P=0.721      P=0.419      P=0.564N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.366N     P=0.753N     P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.281N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    5/50 (10%)  |1/50 (2%)    2/50 (4%)    3/50 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     3/48.24      2/47.90      1/45.68      5/47.85     |1/46.61      2/47.80      3/48.01      4/47.36      | 
|POLY-3 PERCENT (g) |     6.2%         4.2%         2.2%         10.5%       |2.2%         4.2%         6.3%         8.5%         | 
|TERMINAL (d)       |     3/45 (7%)    2/44 (5%)    1/42 (2%)    5/46 (11%)  |1/43 (2%)    2/40 (5%)    3/43 (7%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.227      P=0.510N     P=0.330N     P=0.369     |P=0.107      P=0.475      P=0.305      P=0.176      | 
|POLY 3             |     P=0.211      P=0.503N     P=0.325N     P=0.352     |P=0.117      P=0.509      P=0.316      P=0.184      | 
|POLY 1.5           |     P=0.213      P=0.502N     P=0.318N     P=0.354     |P=0.117      P=0.508      P=0.315      P=0.184      | 
|POLY 6             |     P=0.210      P=0.504N     P=0.333N     P=0.352     |P=0.118      P=0.507      P=0.317      P=0.184      | 
|LOGISTIC REGRESSION|     P=0.227      P=0.510N     P=0.330N     P=0.369     |P=0.111      P=0.475      P=0.305      P=0.153      | 
|COCH-ARM / FISHERS |     P=0.216      P=0.500N     P=0.309N     P=0.357     |P=0.114      P=0.500      P=0.309      P=0.181      | 
|ORDER RESTRICTED   |     P=0.147      (e)          (e)          (e)         |P=0.136      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    6/50 (12%)   2/50 (4%)   |6/50 (12%)   6/50 (12%)   8/50 (16%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     3/48.24      2/47.90      6/45.68      2/47.85     |6/46.61      6/47.80      8/48.01      8/46.05      | 
|POLY-3 PERCENT (g) |     6.2%         4.2%         13.1%        4.2%        |12.9%        12.6%        16.7%        17.4%        | 
|TERMINAL (d)       |     3/45 (7%)    2/44 (5%)    6/42 (14%)   2/46 (4%)   |6/43 (14%)   6/40 (15%)   8/43 (19%)   8/40 (20%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.507N     P=0.510N     P=0.209      P=0.490N    |P=0.252      P=0.570      P=0.386      P=0.330      | 
|POLY 3             |     P=0.524N     P=0.503N     P=0.216      P=0.504N    |P=0.277      P=0.603N     P=0.410      P=0.377      | 
|POLY 1.5           |     P=0.523N     P=0.502N     P=0.226      P=0.503N    |P=0.286      P=0.604N     P=0.406      P=0.386      | 
|POLY 6             |     P=0.525N     P=0.504N     P=0.207      P=0.504N    |P=0.267      P=0.606N     P=0.411      P=0.366      | 
|LOGISTIC REGRESSION|     P=0.507N     P=0.510N     P=0.209      P=0.490N    |P=0.252      P=0.570      P=0.386      P=0.330      | 
|COCH-ARM / FISHERS |     P=0.519N     P=0.500N     P=0.243      P=0.500N    |P=0.291      P=0.620N     P=0.387      P=0.387      | 
|ORDER RESTRICTED   |     P=0.385N     (e)          (e)          (e)         |P=0.422      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   6/50 (12%)   5/50 (10%)   11/50 (22%) |1/50 (2%)    5/50 (10%)   1/50 (2%)    8/50 (16%)   | 
|POLY-3 RATE (b)    |     5/48.89      6/48.36      5/45.68      11/48.45    |1/46.61      5/47.92      1/48.01      8/46.91      | 
|POLY-3 PERCENT (g) |     10.2%        12.4%        11.0%        22.7%       |2.2%         10.4%        2.1%         17.1%        | 
|TERMINAL (d)       |     4/45 (9%)    4/44 (9%)    5/42 (12%)   10/46 (22%) |1/43 (2%)    4/40 (10%)   1/43 (2%)    4/40 (10%)   | 
|FIRST INCIDENCE    |     513          613          729 (T)      537         |729 (T)      697          729 (T)      640          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.060      P=0.489      P=0.589      P=0.098     |P=0.015 *    P=0.092      P=0.762      P=0.018 *    | 
|POLY 3             |     P=0.046 *    P=0.492      P=0.587      P=0.082     |P=0.015 *    P=0.108      P=0.754N     P=0.016 *    | 
|POLY 1.5           |     P=0.047 *    P=0.494      P=0.602      P=0.083     |P=0.015 *    P=0.108      P=0.755N     P=0.016 *    | 
|POLY 6             |     P=0.045 *    P=0.492      P=0.570      P=0.081     |P=0.015 *    P=0.107      P=0.754N     P=0.016 *    | 
|LOGISTIC REGRESSION|     P=0.050      P=0.516      P=0.629N     P=0.090     |P=0.016 *    P=0.107      P=0.762      P=0.018 *    | 
|COCH-ARM / FISHERS |     P=0.050      P=0.500      P=0.630N     P=0.086     |P=0.016 *    P=0.102      P=0.753N     P=0.015 *    | 
|ORDER RESTRICTED   |     P=0.052      (e)          (e)          (e)         |P=0.004 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   3/50 (6%)    1/50 (2%)    9/50 (18%)  |3/50 (6%)    2/50 (4%)    3/50 (6%)    11/50 (22%)  | 
|POLY-3 RATE (b)    |     7/48.37      3/47.90      1/46.28      9/48.21     |3/46.79      2/47.80      3/48.01      11/46.05     | 
|POLY-3 PERCENT (g) |     14.5%        6.3%         2.2%         18.7%       |6.4%         4.2%         6.3%         23.9%        | 
|TERMINAL (d)       |     6/45 (13%)   3/44 (7%)    0/42 (0%)    8/46 (17%)  |1/43 (2%)    2/40 (5%)    3/43 (7%)    11/40 (28%)  | 
|FIRST INCIDENCE    |     695          729 (T)      535          628         |706          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.228      P=0.170N     P=0.044N*    P=0.409     |P<0.001 **   P=0.530N     P=0.659N     P=0.016 *    | 
|POLY 3             |     P=0.206      P=0.162N     P=0.035N*    P=0.390     |P<0.001 **   P=0.490N     P=0.650N     P=0.018 *    | 
|POLY 1.5           |     P=0.207      P=0.161N     P=0.034N*    P=0.390     |P<0.001 **   P=0.490N     P=0.651N     P=0.019 *    | 
|POLY 6             |     P=0.206      P=0.164N     P=0.037N*    P=0.391     |P<0.001 **   P=0.494N     P=0.651N     P=0.016 *    | 
|LOGISTIC REGRESSION|     P=0.212      P=0.162N     P=0.028N*    P=0.388     |P<0.001 **   P=0.490N     P=0.651N     P=0.017 *    | 
|COCH-ARM / FISHERS |     P=0.213      P=0.159N     P=0.030N*    P=0.393     |P=0.002 **   P=0.500N     P=0.661N     P=0.020 *    | 
|ORDER RESTRICTED   |     P=0.052      (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    2/50 (4%)    0/48 (0%)    1/45 (2%)   |1/47 (2%)    0/47 (0%)    2/48 (4%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/46.24      2/47.90      0/43.68      1/43.21     |1/43.70      0/45.20      2/46.34      0/44.35      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         0.0%         2.3%        |2.3%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/43 (0%)    2/44 (5%)    0/40 (0%)    1/42 (2%)   |1/41 (2%)    0/40 (0%)    1/41 (2%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |729 (T)      ---          635          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.529      P=0.244      (e)          P=0.495     |P=0.467N     P=0.505N     P=0.507      P=0.510N     | 
|POLY 3             |     P=0.516      P=0.245      (e)          P=0.486     |P=0.463N     P=0.493N     P=0.520      P=0.497N     | 
|POLY 1.5           |     P=0.516      P=0.245      (e)          P=0.486     |P=0.459N     P=0.494N     P=0.518      P=0.495N     | 
|POLY 6             |     P=0.516      P=0.245      (e)          P=0.487     |P=0.467N     P=0.493N     P=0.522      P=0.499N     | 
|LOGISTIC REGRESSION|     (e)          P=0.244      (e)          P=0.495     |P=0.457N     (e)          P=0.496      (e)          | 
|COCH-ARM / FISHERS |     P=0.519      P=0.258      (e)          P=0.484     |P=0.455N     P=0.500N     P=0.508      P=0.495N     | 
|ORDER RESTRICTED   |     P=0.313      (e)          (e)          (e)         |P=0.322N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/48 (0%)    0/45 (0%)   |0/47 (0%)    0/47 (0%)    1/48 (2%)    3/48 (6%)    | 
|POLY-3 RATE (b)    |     0/46.24      0/47.90      0/43.68      0/43.21     |0/43.70      0/45.20      1/46.18      3/44.35      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.2%         6.8%         | 
|TERMINAL (d)       |     0/43 (0%)    0/44 (0%)    0/40 (0%)    0/42 (0%)   |0/41 (0%)    0/40 (0%)    0/41 (0%)    3/39 (8%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          684          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.019 *    (e)          P=0.509      P=0.112      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.020 *    (e)          P=0.511      P=0.121      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.020 *    (e)          P=0.510      P=0.123      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.019 *    (e)          P=0.512      P=0.119      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.020 *    (e)          P=0.489      P=0.112      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.021 *    (e)          P=0.505      P=0.125      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.021 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/48 (21%)  8/50 (16%)   9/48 (19%)   12/45 (27%) |6/47 (13%)   8/47 (17%)   7/48 (15%)   13/48 (27%)  | 
|POLY-3 RATE (b)    |     10/46.24     8/47.90      9/45.09      12/43.21    |6/44.30      8/45.90      7/46.01      13/44.52     | 
|POLY-3 PERCENT (g) |     21.6%        16.7%        20.0%        27.8%       |13.5%        17.4%        15.2%        29.2%        | 
|TERMINAL (d)       |     10/43 (23%)  8/44 (18%)   7/40 (18%)   12/42 (29%) |5/41 (12%)   5/40 (13%)   7/41 (17%)   12/39 (31%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      441          729 (T)     |539          632          729 (T)      685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.250      P=0.375N     P=0.563N     P=0.378     |P=0.035 *    P=0.382      P=0.501      P=0.051      | 
|POLY 3             |     P=0.210      P=0.366N     P=0.524N     P=0.335     |P=0.041 *    P=0.414      P=0.529      P=0.060      | 
|POLY 1.5           |     P=0.211      P=0.365N     P=0.515N     P=0.335     |P=0.044 *    P=0.409      P=0.530      P=0.064      | 
|POLY 6             |     P=0.211      P=0.367N     P=0.535N     P=0.338     |P=0.037 *    P=0.418      P=0.525      P=0.055      | 
|LOGISTIC REGRESSION|     P=0.211      P=0.375N     P=0.481N     P=0.378     |P=0.045 *    P=0.366      P=0.528      P=0.067      | 
|COCH-ARM / FISHERS |     P=0.214      P=0.361N     P=0.500N     P=0.338     |P=0.048 *    P=0.387      P=0.517      P=0.068      | 
|ORDER RESTRICTED   |     P=0.258      (e)          (e)          (e)         |P=0.042 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/48 (21%)  5/50 (10%)   7/48 (15%)   12/45 (27%) |12/47 (26%)  19/47 (40%)  18/48 (38%)  19/48 (40%)  | 
|POLY-3 RATE (b)    |     10/46.54     5/48.58      7/44.97      12/44.40    |12/43.70     19/46.16     18/46.22     19/45.11     | 
|POLY-3 PERCENT (g) |     21.5%        10.3%        15.6%        27.0%       |27.5%        41.2%        39.0%        42.1%        | 
|TERMINAL (d)       |     8/43 (19%)   3/44 (7%)    4/40 (10%)   10/42 (24%) |12/41 (29%)  16/40 (40%)  16/41 (39%)  16/39 (41%)  | 
|FIRST INCIDENCE    |     685          586          441          355         |729 (T)      525          684          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.190      P=0.134N     P=0.365N     P=0.385     |P=0.103      P=0.086      P=0.137      P=0.072      | 
|POLY 3             |     P=0.153      P=0.111N     P=0.324N     P=0.356     |P=0.146      P=0.125      P=0.175      P=0.108      | 
|POLY 1.5           |     P=0.152      P=0.112N     P=0.314N     P=0.350     |P=0.152      P=0.117      P=0.171      P=0.110      | 
|POLY 6             |     P=0.154      P=0.111N     P=0.335N     P=0.361     |P=0.142      P=0.132      P=0.178      P=0.107      | 
|LOGISTIC REGRESSION|     P=0.157      P=0.111N     P=0.267N     P=0.347     |P=0.135      P=0.110      P=0.166      P=0.097      | 
|COCH-ARM / FISHERS |     P=0.150      P=0.113N     P=0.297N     P=0.338     |P=0.151      P=0.094      P=0.151      P=0.107      | 
|ORDER RESTRICTED   |     P=0.128      (e)          (e)          (e)         |P=0.120      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/48 (0%)    0/50 (0%)   |0/49 (0%)    2/47 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.29      0/47.28      0/44.48      0/47.85     |0/46.61      2/46.24      0/47.01      0/46.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |0/43 (0%)    0/40 (0%)    0/42 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          525          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.416N     P=0.239      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.397N     P=0.235      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.397N     P=0.233      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.398N     P=0.238      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.248N     P=0.115      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.398N     P=0.237      (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.248N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/48 (0%)    1/50 (2%)   |2/49 (4%)    1/47 (2%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.29      0/47.28      0/44.48      1/47.85     |2/47.20      1/45.51      2/47.01      0/46.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.1%        |4.2%         2.2%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    1/46 (2%)   |1/43 (2%)    1/40 (3%)    2/42 (5%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |539          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.205      (e)          (e)          P=0.504     |P=0.211N     P=0.517N     P=0.689      P=0.250N     | 
|POLY 3             |     P=0.201      (e)          (e)          P=0.502     |P=0.206N     P=0.513N     P=0.692      P=0.243N     | 
|POLY 1.5           |     P=0.202      (e)          (e)          P=0.503     |P=0.202N     P=0.513N     P=0.693      P=0.239N     | 
|POLY 6             |     P=0.201      (e)          (e)          P=0.502     |P=0.211N     P=0.513N     P=0.691      P=0.247N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.504     |P=0.165N     P=0.594N     P=0.674      P=0.160N     | 
|COCH-ARM / FISHERS |     P=0.203      (e)          (e)          P=0.505     |P=0.193N     P=0.516N     P=0.691N     P=0.242N     | 
|ORDER RESTRICTED   |     P=0.122      (e)          (e)          (e)         |P=0.160N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    7/48 (15%)   4/48 (8%)    14/50 (28%) |0/49 (0%)    0/47 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/47.43      7/47.28      4/44.48      14/48.15    |0/46.61      0/45.51      0/47.01      0/46.05      | 
|POLY-3 PERCENT (g) |     8.4%         14.8%        9.0%         29.1%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/45 (7%)    7/44 (16%)   4/42 (10%)   13/46 (28%) |0/43 (0%)    0/40 (0%)    0/42 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     695          729 (T)      729 (T)      645         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006 **   P=0.251      P=0.601      P=0.012 *   |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.004 **   P=0.260      P=0.607      P=0.009 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.004 **   P=0.257      P=0.616      P=0.009 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.004 **   P=0.260      P=0.598      P=0.009 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.005 **   P=0.261      P=0.605      P=0.010 *   |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.005 **   P=0.250      P=0.631      P=0.010 *   |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.002 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/49 (14%)   4/48 (8%)    4/48 (8%)    7/50 (14%)  |3/49 (6%)    8/47 (17%)   9/49 (18%)   10/50 (20%)  | 
|POLY-3 RATE (b)    |     7/47.47      4/47.28      4/45.37      7/47.85     |3/46.61      8/45.51      9/47.01      10/46.46     | 
|POLY-3 PERCENT (g) |     14.8%        8.5%         8.8%         14.6%       |6.4%         17.6%        19.2%        21.5%        | 
|TERMINAL (d)       |     6/45 (13%)   4/44 (9%)    3/42 (7%)    7/46 (15%)  |3/43 (7%)    8/40 (20%)   9/42 (21%)   8/40 (20%)   | 
|FIRST INCIDENCE    |     685          729 (T)      348          729 (T)     |729 (T)      729 (T)      729 (T)      665          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.484      P=0.277N     P=0.305N     P=0.599N    |P=0.036 *    P=0.078      P=0.056      P=0.030 *    | 
|POLY 3             |     P=0.473      P=0.264N     P=0.288N     P=0.607N    |P=0.047 *    P=0.091      P=0.061      P=0.034 *    | 
|POLY 1.5           |     P=0.478      P=0.267N     P=0.282N     P=0.603N    |P=0.050      P=0.089      P=0.061      P=0.035 *    | 
|POLY 6             |     P=0.468      P=0.263N     P=0.296N     P=0.611N    |P=0.045 *    P=0.092      P=0.061      P=0.032 *    | 
|LOGISTIC REGRESSION|     P=0.498      P=0.262N     P=0.231N     P=0.606N    |P=0.040 *    P=0.078      P=0.056      P=0.034 *    | 
|COCH-ARM / FISHERS |     P=0.488      P=0.274N     P=0.274N     P=0.597N    |P=0.056      P=0.087      P=0.060      P=0.039 *    | 
|ORDER RESTRICTED   |     P=0.424N     (e)          (e)          (e)         |P=0.032 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Iliac                                                                                                                | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/2 (0%)     0/1 (0%)     0/2 (0%)    |0/3 (0%)     2/9 (22%)    1/12 (8%)    1/7 (14%)    | 
|POLY-3 RATE (b)    |     0/1.83       0/1.95       0/1.00       0/2.00      |0/3.00       2/7.79       1/11.40      1/4.78       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         25.7%        8.8%         20.9%        | 
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/1 (0%)     0/2 (0%)    |0/3 (0%)     0/3 (0%)     1/9 (11%)    1/3 (33%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          632          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.521      P=0.242      P=0.718      P=0.500      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.529      P=0.461      P=0.762      P=0.598      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.571      P=0.479      P=0.764      P=0.626      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.494      P=0.436      P=0.757      P=0.563      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.583      P=0.544      P=0.718      P=0.500      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.645      P=0.545      P=0.800      P=0.700      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.452      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Inguinal                                                                                                             | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/2 (0%)     0/1 (0%)     1/2 (50%)   |0/3 (0%)     2/9 (22%)    1/12 (8%)    0/7 (0%)     | 
|POLY-3 RATE (b)    |     0/1.83       0/1.95       0/1.00       1/2.00      |0/3.00       2/7.79       1/11.40      0/4.78       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         50.0%       |0.0%         25.7%        8.8%         0.0%         | 
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/1 (0%)     1/2 (50%)   |0/3 (0%)     1/3 (33%)    1/9 (11%)    0/3 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          632          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.308      (e)          (e)          P=0.638     |P=0.424N     P=0.247      P=0.718      (e)          | 
|POLY 3             |     P=0.236      (e)          (e)          P=0.518     |P=0.407N     P=0.461      P=0.762      (e)          | 
|POLY 1.5           |     P=0.231      (e)          (e)          P=0.509     |P=0.380N     P=0.479      P=0.764      (e)          | 
|POLY 6             |     P=0.246      (e)          (e)          P=0.533     |P=0.451N     P=0.435      P=0.757      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.638     |P=0.357N     P=0.540      P=0.718      (e)          | 
|COCH-ARM / FISHERS |     P=0.189      (e)          (e)          P=0.500     |P=0.331N     P=0.545      P=0.800      (e)          | 
|ORDER RESTRICTED   |     P=0.141      (e)          (e)          (e)         |P=0.449N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/2 (0%)     0/2 (0%)     0/1 (0%)     0/2 (0%)    |0/3 (0%)     2/9 (22%)    0/12 (0%)    0/7 (0%)     | 
|POLY-3 RATE (b)    |     0/1.83       0/1.95       0/1.00       0/2.00      |0/3.00       2/7.91       0/11.40      0/4.78       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         25.3%        0.0%         0.0%         | 
|TERMINAL (d)       |     0/1 (0%)     0/1 (0%)     0/1 (0%)     0/2 (0%)    |0/3 (0%)     0/3 (0%)     0/9 (0%)     0/3 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          632          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.412N     P=0.244      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.312N     P=0.466      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.305N     P=0.481      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.332N     P=0.445      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.234N     P=0.603      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.293N     P=0.545      (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.382N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |16/50 (32%)  10/50 (20%)  14/49 (29%)  24/49 (49%)  | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      0/45.68      0/47.85     |16/47.77     10/49.04     14/47.94     24/48.29     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |33.5%        20.4%        29.2%        49.7%        | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |14/43 (33%)  6/40 (15%)   12/42 (29%)  18/40 (45%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |539          525          539          409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.014 *    P=0.173N     P=0.436N     P=0.061      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.013 *    P=0.110N     P=0.409N     P=0.079      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.013 *    P=0.112N     P=0.412N     P=0.076      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.013 *    P=0.109N     P=0.408N     P=0.079      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.013 *    P=0.140N     P=0.446N     P=0.063      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.012 *    P=0.127N     P=0.440N     P=0.064      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.010 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/4 (75%)    3/7 (43%)    2/2 (100%)   2/3 (67%)   |3/3 (100%)   3/7 (43%)    3/7 (43%)    3/4 (75%)    | 
|POLY-3 RATE (b)    |     3/4.00       3/6.74       2/2.00       2/3.00      |3/3.00       3/6.15       3/6.74       3/4.00       | 
|POLY-3 PERCENT (g) |     75.0%        44.5%        100.0%       66.7%       |100.0%       48.8%        44.5%        75.0%        | 
|TERMINAL (d)       |     3/4 (75%)    3/5 (60%)    2/2 (100%)   2/3 (67%)   |3/3 (100%)   3/4 (75%)    2/4 (50%)    3/4 (75%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      720          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.653      P=0.588N     P=0.638      P=0.712N    |P=0.465N     P=0.557N     P=0.567N     P=0.557N     | 
|POLY 3             |     P=0.568      P=0.372N     P=0.631      P=0.696N    |P=0.566N     P=0.188N     P=0.156N     P=0.556N     | 
|POLY 1.5           |     P=0.561      P=0.362N     P=0.631      P=0.696N    |P=0.587N     P=0.167N     P=0.152N     P=0.556N     | 
|POLY 6             |     P=0.580      P=0.392N     P=0.631      P=0.696N    |P=0.539N     P=0.224N     P=0.165N     P=0.556N     | 
|LOGISTIC REGRESSION|     P=0.653      P=0.588N     P=0.638      P=0.712N    |P=0.437N     P=0.557N     P=0.347N     P=0.557N     | 
|COCH-ARM / FISHERS |     P=0.556      P=0.348N     P=0.667      P=0.714N    |P=0.617N     P=0.167N     P=0.167N     P=0.571N     | 
|ORDER RESTRICTED   |     P=0.435      (e)          (e)          (e)         |P=0.239N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/48.89      0/47.90      2/45.84      0/47.85     |1/47.21      0/46.80      0/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         4.4%         0.0%        |2.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    1/42 (2%)    0/46 (0%)   |0/43 (0%)    0/39 (0%)    0/43 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     513          ---          686          ---         |539          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.462N     P=0.500N     P=0.479      P=0.500N    |P=0.308N     P=0.500N     P=0.496N     P=0.504N     | 
|POLY 3             |     P=0.464N     P=0.504N     P=0.478      P=0.504N    |P=0.303N     P=0.502N     P=0.497N     P=0.505N     | 
|POLY 1.5           |     P=0.463N     P=0.503N     P=0.486      P=0.503N    |P=0.305N     P=0.501N     P=0.497N     P=0.502N     | 
|POLY 6             |     P=0.465N     P=0.506N     P=0.470      P=0.506N    |P=0.300N     P=0.504N     P=0.497N     P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.436N     P=0.375N     P=0.596      P=0.377N    |P=0.378N     P=0.632N     P=0.628N     P=0.574N     | 
|COCH-ARM / FISHERS |     P=0.461N     P=0.500N     P=0.500      P=0.500N    |P=0.305N     P=0.505N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.319N     (e)          (e)          (e)         |P=0.125N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |9/48 (19%)   9/49 (18%)   7/49 (14%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |                                                        |9/44.70      9/47.65      7/47.01      6/46.05      | 
|POLY-3 PERCENT (g) |                                                        |20.1%        18.9%        14.9%        13.0%        | 
|TERMINAL (d)       |                                                        |8/41 (20%)   7/39 (18%)   7/42 (17%)   6/40 (15%)   | 
|FIRST INCIDENCE    |                                                        |706          525          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.210N     P=0.562      P=0.374N     P=0.309N     | 
|POLY 3             |                                                        |P=0.195N     P=0.544N     P=0.351N     P=0.266N     | 
|POLY 1.5           |                                                        |P=0.187N     P=0.552N     P=0.354N     P=0.259N     | 
|POLY 6             |                                                        |P=0.204N     P=0.541N     P=0.350N     P=0.276N     | 
|LOGISTIC REGRESSION|                                                        |P=0.188N     P=0.574N     P=0.351N     P=0.290N     | 
|COCH-ARM / FISHERS |                                                        |P=0.182N     P=0.584N     P=0.375N     P=0.259N     | 
|ORDER RESTRICTED   |                                                        |P=0.295N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |16/48 (33%)  20/49 (41%)  14/49 (29%)  19/50 (38%)  | 
|POLY-3 RATE (b)    |                                                        |16/45.70     20/47.52     14/47.01     19/46.22     | 
|POLY-3 PERCENT (g) |                                                        |35.0%        42.1%        29.8%        41.1%        | 
|TERMINAL (d)       |                                                        |14/41 (34%)  18/39 (46%)  14/42 (33%)  18/40 (45%)  | 
|FIRST INCIDENCE    |                                                        |114          525          729 (T)      685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.397      P=0.213      P=0.385N     P=0.302      | 
|POLY 3             |                                                        |P=0.415      P=0.313      P=0.376N     P=0.349      | 
|POLY 1.5           |                                                        |P=0.433      P=0.306      P=0.380N     P=0.365      | 
|POLY 6             |                                                        |P=0.395      P=0.312      P=0.376N     P=0.330      | 
|LOGISTIC REGRESSION|                                                        |P=0.458      P=0.276      P=0.391N     P=0.394      | 
|COCH-ARM / FISHERS |                                                        |P=0.466      P=0.290      P=0.387N     P=0.393      | 
|ORDER RESTRICTED   |                                                        |P=0.432      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    1/50 (2%)    0/50 (0%)   |3/49 (6%)    1/48 (2%)    0/48 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/47.37      0/47.38      1/45.68      0/47.85     |3/46.61      1/46.15      0/46.09      0/45.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |6.4%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    1/42 (2%)    0/46 (0%)   |3/43 (7%)    1/40 (3%)    0/42 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.694      (e)          P=0.486      (e)         |P=0.049N*    P=0.331N     P=0.125N     P=0.139N     | 
|POLY 3             |     P=0.696      (e)          P=0.493      (e)         |P=0.044N*    P=0.309N     P=0.121N     P=0.125N     | 
|POLY 1.5           |     P=0.696      (e)          P=0.497      (e)         |P=0.044N*    P=0.310N     P=0.121N     P=0.123N     | 
|POLY 6             |     P=0.696      (e)          P=0.488      (e)         |P=0.044N*    P=0.309N     P=0.120N     P=0.128N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.486      (e)         |P=0.049N*    P=0.331N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.697      (e)          P=0.505      (e)         |P=0.044N*    P=0.316N     P=0.125N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.374      (e)          (e)          (e)         |P=0.023N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    0/49 (0%)    1/49 (2%)    1/49 (2%)   |0/49 (0%)    1/49 (2%)    5/48 (10%)   2/47 (4%)    | 
|POLY-3 RATE (b)    |     1/45.29      0/47.10      1/44.68      1/47.45     |0/46.21      1/46.90      5/46.26      2/43.35      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.2%         2.1%        |0.0%         2.1%         10.8%        4.6%         | 
|TERMINAL (d)       |     1/43 (2%)    0/44 (0%)    1/41 (2%)    1/46 (2%)   |0/43 (0%)    0/40 (0%)    5/43 (12%)   2/38 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |---          705          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.553      P=0.495N     P=0.751      P=0.747N    |P=0.138      P=0.491      P=0.033 *    P=0.212      | 
|POLY 3             |     P=0.549      P=0.492N     P=0.757      P=0.750N    |P=0.137      P=0.503      P=0.031 *    P=0.223      | 
|POLY 1.5           |     P=0.548      P=0.492N     P=0.759N     P=0.751N    |P=0.143      P=0.503      P=0.031 *    P=0.226      | 
|POLY 6             |     P=0.550      P=0.492N     P=0.753      P=0.749N    |P=0.131      P=0.501      P=0.031 *    P=0.219      | 
|LOGISTIC REGRESSION|     P=0.553      (e)          P=0.751      P=0.747N    |P=0.138      P=0.497      P=0.033 *    P=0.212      | 
|COCH-ARM / FISHERS |     P=0.548      P=0.490N     P=0.742N     P=0.742N    |P=0.152      P=0.500      P=0.027 *    P=0.237      | 
|ORDER RESTRICTED   |     P=0.533      (e)          (e)          (e)         |P=0.051      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    3/48 (6%)    3/49 (6%)    2/50 (4%)   |1/49 (2%)    3/46 (7%)    4/49 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/47.37      3/46.38      3/44.68      2/47.85     |1/45.61      3/44.25      4/47.04      0/46.05      | 
|POLY-3 PERCENT (g) |     2.1%         6.5%         6.7%         4.2%        |2.2%         6.8%         8.5%         0.0%         | 
|TERMINAL (d)       |     1/45 (2%)    3/43 (7%)    3/41 (7%)    2/46 (4%)   |1/42 (2%)    3/38 (8%)    4/43 (9%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.490      P=0.289      P=0.273      P=0.508     |P=0.317N     P=0.270      P=0.187      P=0.510N     | 
|POLY 3             |     P=0.482      P=0.298      P=0.285      P=0.503     |P=0.306N     P=0.294      P=0.188      P=0.498N     | 
|POLY 1.5           |     P=0.485      P=0.298      P=0.292      P=0.505     |P=0.299N     P=0.293      P=0.187      P=0.496N     | 
|POLY 6             |     P=0.480      P=0.298      P=0.277      P=0.502     |P=0.314N     P=0.295      P=0.189      P=0.501N     | 
|LOGISTIC REGRESSION|     P=0.490      P=0.289      P=0.273      P=0.508     |P=0.317N     P=0.270      P=0.187      (e)          | 
|COCH-ARM / FISHERS |     P=0.490      P=0.301      P=0.309      P=0.508     |P=0.298N     P=0.285      P=0.181      P=0.495N     | 
|ORDER RESTRICTED   |     P=0.320      (e)          (e)          (e)         |P=0.131N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/49 (0%)    0/50 (0%)   |2/49 (4%)    4/46 (9%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.37      0/46.38      0/44.68      0/47.85     |2/45.61      4/44.26      1/47.04      0/46.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         9.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     0/45 (0%)    0/43 (0%)    0/41 (0%)    0/46 (0%)   |2/42 (5%)    3/38 (8%)    1/43 (2%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      727          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.089N     P=0.297      P=0.492N     P=0.249N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.081N     P=0.323      P=0.489N     P=0.235N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.079N     P=0.321      P=0.491N     P=0.233N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.082N     P=0.324      P=0.488N     P=0.238N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.088N     P=0.307      P=0.492N     (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.081N     P=0.309      P=0.500N     P=0.242N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.069N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  27/50 (54%)  31/50 (62%)  36/50 (72%) |                                                    | 
|POLY-3 RATE (b)    |     29/49.12     27/48.43     31/47.00     36/48.81    |                                                    | 
|POLY-3 PERCENT (g) |     59.0%        55.8%        66.0%        73.8%       |                                                    | 
|TERMINAL (d)       |     26/45 (58%)  25/44 (57%)  28/42 (67%)  34/46 (74%) |                                                    | 
|FIRST INCIDENCE    |     513          586          441          537         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.076      P=0.468N     P=0.277      P=0.145     |                                                    | 
|POLY 3             |     P=0.040 *    P=0.451N     P=0.312      P=0.090     |                                                    | 
|POLY 1.5           |     P=0.042 *    P=0.442N     P=0.350      P=0.093     |                                                    | 
|POLY 6             |     P=0.038 *    P=0.462N     P=0.274      P=0.089     |                                                    | 
|LOGISTIC REGRESSION|     P=0.042 *    P=0.431N     P=0.333      P=0.097     |                                                    | 
|COCH-ARM / FISHERS |     P=0.050      P=0.420N     P=0.419      P=0.104     |                                                    | 
|ORDER RESTRICTED   |     P=0.064      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/50 (34%)  19/50 (38%)  24/50 (48%)  23/50 (46%) |                                                    | 
|POLY-3 RATE (b)    |     17/48.95     19/47.95     24/48.25     23/48.45    |                                                    | 
|POLY-3 PERCENT (g) |     34.7%        39.6%        49.7%        47.5%       |                                                    | 
|TERMINAL (d)       |     15/45 (33%)  18/44 (41%)  20/42 (48%)  22/46 (48%) |                                                    | 
|FIRST INCIDENCE    |     513          716          348          537         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.136      P=0.390      P=0.080      P=0.181     |                                                    | 
|POLY 3             |     P=0.100      P=0.387      P=0.097      P=0.141     |                                                    | 
|POLY 1.5           |     P=0.103      P=0.397      P=0.103      P=0.145     |                                                    | 
|POLY 6             |     P=0.099      P=0.376      P=0.090      P=0.139     |                                                    | 
|LOGISTIC REGRESSION|     P=0.107      P=0.409      P=0.135      P=0.150     |                                                    | 
|COCH-ARM / FISHERS |     P=0.108      P=0.418      P=0.111      P=0.154     |                                                    | 
|ORDER RESTRICTED   |     P=0.127      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/48 (0%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      0/45.68      0/47.85     |0/46.61      0/46.16      0/48.01      2/45.35      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |0/43 (0%)    0/40 (0%)    0/43 (0%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.223      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.044 *    (e)          (e)          P=0.231      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.233      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.044 *    (e)          (e)          P=0.229      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          P=0.223      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.242      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.027 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    4/48 (8%)    3/50 (6%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     0/48.24      0/47.90      0/45.68      0/47.85     |3/46.61      4/46.20      3/48.01      3/45.35      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.4%         8.7%         6.3%         6.6%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |3/43 (7%)    3/40 (8%)    3/43 (7%)    3/40 (8%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      721          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.547N     P=0.463      P=0.663      P=0.629      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.529N     P=0.495      P=0.648N     P=0.649      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.524N     P=0.492      P=0.650N     P=0.653      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.534N     P=0.495      P=0.648N     P=0.645      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.549N     P=0.480      P=0.663      P=0.629      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.523N     P=0.477      P=0.661N     P=0.651      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.646N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/48.24      2/49.28      0/45.68      0/46.85     |0/46.61      0/47.80      1/48.18      1/46.12      | 
|POLY-3 PERCENT (g) |     0.0%         4.1%         0.0%         0.0%        |0.0%         0.0%         2.1%         2.2%         | 
|TERMINAL (d)       |     0/45 (0%)    0/44 (0%)    0/42 (0%)    0/45 (0%)   |0/43 (0%)    0/40 (0%)    0/43 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          335          ---          ---         |---          ---          685          711          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.407N     P=0.242      (e)          (e)         |P=0.228      (e)          P=0.504      P=0.490      | 
|POLY 3             |     P=0.411N     P=0.242      (e)          (e)         |P=0.230      (e)          P=0.507      P=0.498      | 
|POLY 1.5           |     P=0.410N     P=0.241      (e)          (e)         |P=0.234      (e)          P=0.505      P=0.500      | 
|POLY 6             |     P=0.412N     P=0.243      (e)          (e)         |P=0.227      (e)          P=0.507      P=0.495      | 
|LOGISTIC REGRESSION|     P=0.290N     P=0.236      (e)          (e)         |P=0.236      (e)          P=0.485      P=0.500      | 
|COCH-ARM / FISHERS |     P=0.409N     P=0.247      (e)          (e)         |P=0.235      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.257N     (e)          (e)          (e)         |P=0.249      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Epidermis                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    0/49 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/48.24      0/47.90      2/45.68      0/46.85     |0/46.61      1/47.80      0/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         4.4%         0.0%        |0.0%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/45 (4%)    0/44 (0%)    2/42 (5%)    0/45 (0%)   |0/43 (0%)    1/40 (3%)    0/43 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.250N     P=0.243N     P=0.670      P=0.239N    |P=0.574N     P=0.486      (e)          (e)          | 
|POLY 3             |     P=0.253N     P=0.239N     P=0.674      P=0.244N    |P=0.562N     P=0.505      (e)          (e)          | 
|POLY 1.5           |     P=0.253N     P=0.239N     P=0.681      P=0.243N    |P=0.563N     P=0.505      (e)          (e)          | 
|POLY 6             |     P=0.253N     P=0.239N     P=0.667      P=0.244N    |P=0.563N     P=0.504      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.250N     (e)          P=0.670      (e)         |(e)          P=0.486      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.252N     P=0.247N     P=0.691N     P=0.253N    |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.122N     (e)          (e)          (e)         |P=0.388N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/49 (20%)  14/49 (29%)  9/50 (18%)   12/50 (24%) |15/49 (31%)  16/49 (33%)  13/49 (27%)  11/49 (22%)  | 
|POLY-3 RATE (b)    |     10/48.83     14/48.04     9/47.70      12/48.76    |15/47.38     16/48.53     13/48.15     11/45.92     | 
|POLY-3 PERCENT (g) |     20.5%        29.1%        18.9%        24.6%       |31.7%        33.0%        27.0%        24.0%        | 
|TERMINAL (d)       |     6/44 (14%)   11/44 (25%)  5/42 (12%)   10/46 (22%) |12/43 (28%)  12/40 (30%)  10/43 (23%)  8/40 (20%)   | 
|FIRST INCIDENCE    |     459          613          441          537         |539          525          539          665          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.516      P=0.253      P=0.547N     P=0.440     |P=0.212N     P=0.431      P=0.410N     P=0.323N     | 
|POLY 3             |     P=0.488      P=0.227      P=0.522N     P=0.403     |P=0.190N     P=0.532      P=0.392N     P=0.275N     | 
|POLY 1.5           |     P=0.496      P=0.230      P=0.509N     P=0.410     |P=0.180N     P=0.520      P=0.400N     P=0.266N     | 
|POLY 6             |     P=0.482      P=0.227      P=0.534N     P=0.399     |P=0.198N     P=0.542      P=0.385N     P=0.284N     | 
|LOGISTIC REGRESSION|     P=0.543      P=0.234      P=0.320N     P=0.447     |P=0.142N     P=0.472      P=0.425N     P=0.258N     | 
|COCH-ARM / FISHERS |     P=0.515      P=0.241      P=0.480N     P=0.426     |P=0.160N     P=0.500      P=0.412N     P=0.246N     | 
|ORDER RESTRICTED   |     P=0.496      (e)          (e)          (e)         |P=0.300N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    2/50 (4%)    2/50 (4%)   |8/49 (16%)   11/49 (22%)  8/49 (16%)   11/49 (22%)  | 
|POLY-3 RATE (b)    |     1/47.24      1/47.38      2/45.68      2/47.85     |8/46.61      11/47.15     8/47.04      11/45.52     | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         4.4%         4.2%        |17.2%        23.3%        17.0%        24.2%        | 
|TERMINAL (d)       |     1/44 (2%)    1/44 (2%)    2/42 (5%)    2/46 (4%)   |8/43 (19%)   11/40 (28%)  8/43 (19%)   10/40 (25%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.353      P=0.762      P=0.484      P=0.516     |P=0.287      P=0.243      P=0.609      P=0.247      | 
|POLY 3             |     P=0.342      P=0.760N     P=0.488      P=0.504     |P=0.311      P=0.314      P=0.600N     P=0.284      | 
|POLY 1.5           |     P=0.343      P=0.760N     P=0.495      P=0.505     |P=0.319      P=0.312      P=0.602N     P=0.291      | 
|POLY 6             |     P=0.341      P=0.759N     P=0.481      P=0.504     |P=0.304      P=0.313      P=0.598N     P=0.278      | 
|LOGISTIC REGRESSION|     P=0.353      P=0.762      P=0.484      P=0.516     |P=0.278      P=0.243      P=0.609      P=0.262      | 
|COCH-ARM / FISHERS |     P=0.345      P=0.753N     P=0.508      P=0.508     |P=0.335      P=0.305      P=0.607N     P=0.305      | 
|ORDER RESTRICTED   |     P=0.435      (e)          (e)          (e)         |P=0.324      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/49 (20%)  8/49 (16%)   2/50 (4%)    7/50 (14%)  |14/49 (29%)  12/49 (24%)  12/49 (24%)  13/49 (27%)  | 
|POLY-3 RATE (b)    |     10/47.24     8/47.38      2/45.68      7/47.85     |14/46.61     12/47.42     12/47.04     13/46.15     | 
|POLY-3 PERCENT (g) |     21.2%        16.9%        4.4%         14.6%       |30.0%        25.3%        25.5%        28.2%        | 
|TERMINAL (d)       |     10/44 (23%)  8/44 (18%)   2/42 (5%)    7/46 (15%)  |14/43 (33%)  11/40 (28%)  12/43 (28%)  11/40 (28%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      656          729 (T)      552          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.170N     P=0.396N     P=0.019N*    P=0.262N    |P=0.541      P=0.489N     P=0.408N     P=0.581N     | 
|POLY 3             |     P=0.185N     P=0.395N     P=0.016N*    P=0.287N    |P=0.507N     P=0.389N     P=0.398N     P=0.512N     | 
|POLY 1.5           |     P=0.182N     P=0.397N     P=0.014N*    P=0.286N    |P=0.502N     P=0.397N     P=0.403N     P=0.510N     | 
|POLY 6             |     P=0.188N     P=0.392N     P=0.017N*    P=0.288N    |P=0.509N     P=0.384N     P=0.396N     P=0.512N     | 
|LOGISTIC REGRESSION|     P=0.170N     P=0.396N     P=0.019N*    P=0.262N    |P=0.533N     P=0.401N     P=0.408N     P=0.533N     | 
|COCH-ARM / FISHERS |     P=0.178N     P=0.397N     P=0.013N*    P=0.282N    |P=0.489N     P=0.410N     P=0.410N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.078N     (e)          (e)          (e)         |P=0.541N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Diverticulum                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/47.24      2/47.90      1/45.68      1/47.85     |2/46.61      0/47.80      0/48.01      0/46.05      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         2.2%         2.1%        |4.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    2/44 (5%)    1/42 (2%)    1/46 (2%)   |2/43 (5%)    0/40 (0%)    0/43 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.512      P=0.238      P=0.491      P=0.509     |P=0.119N     P=0.254N     P=0.238N     P=0.254N     | 
|POLY 3             |     P=0.501      P=0.240      P=0.493      P=0.503     |P=0.114N     P=0.232N     P=0.231N     P=0.240N     | 
|POLY 1.5           |     P=0.502      P=0.241      P=0.497      P=0.503     |P=0.115N     P=0.232N     P=0.232N     P=0.238N     | 
|POLY 6             |     P=0.500      P=0.240      P=0.489      P=0.502     |P=0.113N     P=0.233N     P=0.230N     P=0.243N     | 
|LOGISTIC REGRESSION|     (e)          P=0.238      P=0.491      P=0.509     |P=0.119N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.505      P=0.253      P=0.505      P=0.505     |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.269      (e)          (e)          (e)         |P=0.030N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/47.24      0/47.90      2/45.68      0/47.85     |0/46.61      0/47.80      1/48.01      1/46.12      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.4%         0.0%        |0.0%         0.0%         2.1%         2.2%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    2/42 (5%)    0/46 (0%)   |0/43 (0%)    0/40 (0%)    1/43 (2%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          729 (T)      711          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.602      (e)          P=0.228      (e)         |P=0.228      (e)          P=0.500      P=0.490      | 
|POLY 3             |     P=0.599      (e)          P=0.230      (e)         |P=0.230      (e)          P=0.506      P=0.498      | 
|POLY 1.5           |     P=0.599      (e)          P=0.234      (e)         |P=0.234      (e)          P=0.505      P=0.500      | 
|POLY 6             |     P=0.600      (e)          P=0.226      (e)         |P=0.227      (e)          P=0.506      P=0.495      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.228      (e)         |P=0.231      (e)          P=0.500      P=0.500      | 
|COCH-ARM / FISHERS |     P=0.598      (e)          P=0.253      (e)         |P=0.235      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.241      (e)          (e)          (e)         |P=0.249      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    2/50 (4%)    4/50 (8%)    0/50 (0%)   |3/50 (6%)    5/50 (10%)   2/50 (4%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     3/47.29      2/48.10      4/46.57      0/47.85     |3/47.17      5/47.90      2/48.01      5/47.71      | 
|POLY-3 PERCENT (g) |     6.3%         4.2%         8.6%         0.0%        |6.4%         10.4%        4.2%         10.5%        | 
|TERMINAL (d)       |     2/44 (5%)    1/44 (2%)    3/42 (7%)    0/46 (0%)   |2/43 (5%)    4/40 (10%)   2/43 (5%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     715          676          348          ---         |555          702          729 (T)      409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.137N     P=0.502N     P=0.475      P=0.118N    |P=0.354      P=0.331      P=0.498N     P=0.340      | 
|POLY 3             |     P=0.135N     P=0.492N     P=0.492      P=0.117N    |P=0.381      P=0.365      P=0.492N     P=0.363      | 
|POLY 1.5           |     P=0.134N     P=0.492N     P=0.500      P=0.116N    |P=0.383      P=0.366      P=0.492N     P=0.365      | 
|POLY 6             |     P=0.135N     P=0.492N     P=0.482      P=0.117N    |P=0.377      P=0.360      P=0.494N     P=0.357      | 
|LOGISTIC REGRESSION|     P=0.119N     P=0.491N     P=0.589      P=0.118N    |P=0.360      P=0.347      P=0.521N     P=0.312      | 
|COCH-ARM / FISHERS |     P=0.132N     P=0.490N     P=0.511      P=0.117N    |P=0.376      P=0.357      P=0.500N     P=0.357      | 
|ORDER RESTRICTED   |     P=0.109N     (e)          (e)          (e)         |P=0.364      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    1/49 (2%)    1/50 (2%)   |0/49 (0%)    0/49 (0%)    2/50 (4%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/47.41      0/47.90      1/45.19      1/48.21     |0/46.61      0/46.80      2/48.27      1/45.57      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         2.2%         2.1%        |0.0%         0.0%         4.1%         2.2%         | 
|TERMINAL (d)       |     1/44 (2%)    0/44 (0%)    0/42 (0%)    0/46 (0%)   |0/43 (0%)    0/40 (0%)    0/43 (0%)    0/39 (0%)    | 
|FIRST INCIDENCE    |     685          ---          632          628         |---          ---          684          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.502N     P=0.244N     P=0.531N     P=0.500N    |P=0.239      (e)          P=0.247      P=0.504      | 
|POLY 3             |     P=0.497N     P=0.235N     P=0.517N     P=0.494N    |P=0.236      (e)          P=0.245      P=0.496      | 
|POLY 1.5           |     P=0.497N     P=0.234N     P=0.511N     P=0.494N    |P=0.239      (e)          P=0.244      P=0.497      | 
|POLY 6             |     P=0.496N     P=0.236N     P=0.522N     P=0.494N    |P=0.232      (e)          P=0.247      P=0.494      | 
|LOGISTIC REGRESSION|     P=0.481N     P=0.231N     P=0.463N     P=0.474N    |P=0.333      (e)          P=0.232      P=0.645      | 
|COCH-ARM / FISHERS |     P=0.496N     P=0.242N     P=0.500N     P=0.492N    |P=0.245      (e)          P=0.253      P=0.500      | 
|ORDER RESTRICTED   |     P=0.271N     (e)          (e)          (e)         |P=0.174      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    1/50 (2%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     0/48.24      3/47.90      1/45.68      3/48.15     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         6.3%         2.2%         6.2%        |                                                    | 
|TERMINAL (d)       |     0/45 (0%)    3/44 (7%)    1/42 (2%)    2/46 (4%)   |                                                    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      645         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.173      P=0.117      P=0.486      P=0.125     |                                                    | 
|POLY 3             |     P=0.162      P=0.118      P=0.489      P=0.119     |                                                    | 
|POLY 1.5           |     P=0.163      P=0.118      P=0.493      P=0.119     |                                                    | 
|POLY 6             |     P=0.163      P=0.117      P=0.485      P=0.119     |                                                    | 
|LOGISTIC REGRESSION|     P=0.164      P=0.117      P=0.486      P=0.123     |                                                    | 
|COCH-ARM / FISHERS |     P=0.165      P=0.121      P=0.500      P=0.121     |                                                    | 
|ORDER RESTRICTED   |     P=0.076      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/48 (15%)   7/49 (14%)   5/45 (11%)   8/45 (18%)  |3/49 (6%)    6/49 (12%)   2/50 (4%)    5/48 (10%)   | 
|POLY-3 RATE (b)    |     7/48.00      7/48.54      5/44.40      8/44.12     |3/47.26      6/48.01      2/48.52      5/44.94      | 
|POLY-3 PERCENT (g) |     14.6%        14.4%        11.3%        18.1%       |6.4%         12.5%        4.1%         11.1%        | 
|TERMINAL (d)       |     3/44 (7%)    4/44 (9%)    1/40 (3%)    5/41 (12%)  |0/42 (0%)    0/39 (0%)    0/43 (0%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     459          335          348          537         |114          525          635          569          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.424      P=0.603      P=0.437N     P=0.467     |P=0.408      P=0.250      P=0.486N     P=0.342      | 
|POLY 3             |     P=0.379      P=0.604N     P=0.435N     P=0.430     |P=0.401      P=0.251      P=0.488N     P=0.329      | 
|POLY 1.5           |     P=0.382      P=0.601N     P=0.431N     P=0.434     |P=0.407      P=0.248      P=0.489N     P=0.335      | 
|POLY 6             |     P=0.378      P=0.609N     P=0.439N     P=0.428     |P=0.395      P=0.252      P=0.487N     P=0.324      | 
|LOGISTIC REGRESSION|     P=0.542      P=0.521N     P=0.094N     P=0.546     |P=0.455      P=0.073      P=0.659      P=0.301      | 
|COCH-ARM / FISHERS |     P=0.392      P=0.597N     P=0.426N     P=0.445     |P=0.418      P=0.243      P=0.490N     P=0.346      | 
|ORDER RESTRICTED   |     P=0.421      (e)          (e)          (e)         |P=0.330      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/45 (0%)    0/45 (0%)   |3/49 (6%)    1/49 (2%)    2/50 (4%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/46.89      0/47.38      0/41.85      0/42.85     |3/45.61      1/46.80      2/48.01      0/44.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.6%         2.1%         4.2%         0.0%         | 
|TERMINAL (d)       |     0/44 (0%)    0/44 (0%)    0/40 (0%)    0/41 (0%)   |3/42 (7%)    1/39 (3%)    2/43 (5%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.113N     P=0.332N     P=0.489N     P=0.139N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.109N     P=0.296N     P=0.477N     P=0.125N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.108N     P=0.297N     P=0.479N     P=0.123N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.111N     P=0.298N     P=0.476N     P=0.128N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.113N     P=0.332N     P=0.489N     (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.105N     P=0.309N     P=0.490N     P=0.125N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.061N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  13/50 (26%)  13/50 (26%)  14/50 (28%) |20/50 (40%)  22/49 (45%)  29/50 (58%)  30/48 (63%)  | 
|POLY-3 RATE (b)    |     13/48.41     13/48.31     13/46.83     14/48.52    |20/47.17     22/48.14     29/49.28     30/45.68     | 
|POLY-3 PERCENT (g) |     26.9%        26.9%        27.8%        28.9%       |42.4%        45.7%        58.8%        65.7%        | 
|TERMINAL (d)       |     12/45 (27%)  12/44 (27%)  11/42 (26%)  12/46 (26%) |18/43 (42%)  17/40 (43%)  25/43 (58%)  26/39 (67%)  | 
|FIRST INCIDENCE    |     685          613          441          628         |593          525          539          447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.471      P=0.563      P=0.510      P=0.520     |P=0.009 **   P=0.333      P=0.067      P=0.015 *    | 
|POLY 3             |     P=0.445      P=0.588      P=0.552      P=0.503     |P=0.008 **   P=0.453      P=0.077      P=0.018 *    | 
|POLY 1.5           |     P=0.444      P=0.587      P=0.566      P=0.500     |P=0.009 **   P=0.439      P=0.071      P=0.020 *    | 
|POLY 6             |     P=0.451      P=0.587      P=0.536      P=0.509     |P=0.007 **   P=0.461      P=0.084      P=0.016 *    | 
|LOGISTIC REGRESSION|     P=0.441      P=0.583      P=0.573      P=0.494     |P=0.009 **   P=0.414      P=0.066      P=0.019 *    | 
|COCH-ARM / FISHERS |     P=0.446      P=0.590N     P=0.590N     P=0.500     |P=0.010 *    P=0.386      P=0.055      P=0.021 *    | 
|ORDER RESTRICTED   |     P=0.640      (e)          (e)          (e)         |P=0.016 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/4 (75%)    0/0 (0%)     0/0 (0%)     2/3 (67%)   |0/0 (0%)     0/1 (0%)     0/0 (0%)     0/1 (0%)     | 
|POLY-3 RATE (b)    |     3/4.00       0/0.00       0/0.00       2/3.00      |0/0.00       0/0.99       0/0.00       0/1.00       | 
|POLY-3 PERCENT (g) |     75.0%        0.0%         0.0%         66.7%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/4 (75%)    0/0 (0%)     0/0 (0%)     2/3 (67%)   |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/1 (0%)     | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.567N     P=1.000      P=1.000N     P=0.712N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          P=0.696N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          P=0.696N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          P=0.696N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.567N     (e)          (e)          P=0.712N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.572N     P=1.000      P=1.000      P=0.714N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/48.24      0/46.90      0/44.68      0/47.85     |1/46.61      3/47.80      4/48.78      3/46.05      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         6.3%         8.2%         6.5%         | 
|TERMINAL (d)       |     0/45 (0%)    0/43 (0%)    0/41 (0%)    0/46 (0%)   |1/43 (2%)    3/40 (8%)    2/43 (5%)    3/40 (8%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      539          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.263      P=0.280      P=0.188      P=0.280      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.274      P=0.315      P=0.193      P=0.301      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.280      P=0.314      P=0.190      P=0.305      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.266      P=0.313      P=0.196      P=0.296      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.283      P=0.280      P=0.150      P=0.280      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.282      P=0.309      P=0.181      P=0.309      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.228      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    3/50 (6%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |0/46.61      3/47.80      0/48.01      3/46.05      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         6.3%         0.0%         6.5%         | 
|TERMINAL (d)       |                                                        |0/43 (0%)    3/40 (8%)    0/43 (0%)    3/40 (8%)    | 
|FIRST INCIDENCE    |                                                        |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.151      P=0.109      (e)          P=0.109      | 
|POLY 3             |                                                        |P=0.161      P=0.123      (e)          P=0.117      | 
|POLY 1.5           |                                                        |P=0.163      P=0.123      (e)          P=0.119      | 
|POLY 6             |                                                        |P=0.158      P=0.122      (e)          P=0.114      | 
|LOGISTIC REGRESSION|                                                        |(e)          P=0.109      (e)          P=0.109      | 
|COCH-ARM / FISHERS |                                                        |P=0.164      P=0.121      (e)          P=0.121      | 
|ORDER RESTRICTED   |                                                        |P=0.053      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |45/50 (90%)  47/50 (94%)  46/50 (92%)  47/50 (94%)  | 
|POLY-3 RATE (b)    |                                                        |45/48.32     47/49.99     46/48.98     47/48.41     | 
|POLY-3 PERCENT (g) |                                                        |93.1%        94.0%        93.9%        97.1%        | 
|TERMINAL (d)       |                                                        |41/43 (95%)  38/40 (95%)  42/43 (98%)  39/40 (98%)  | 
|FIRST INCIDENCE    |                                                        |539          525          539          552          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.193      P=0.179      P=0.512      P=0.150      | 
|POLY 3             |                                                        |P=0.245      P=0.593      P=0.607      P=0.322      | 
|POLY 1.5           |                                                        |P=0.300      P=0.541      P=0.612      P=0.360      | 
|POLY 6             |                                                        |P=0.214      P=0.645      P=0.578      P=0.315      | 
|LOGISTIC REGRESSION|                                                        |P=0.266      P=0.508      P=0.599N     P=0.311      | 
|COCH-ARM / FISHERS |                                                        |P=0.342      P=0.357      P=0.500      P=0.357      | 
|ORDER RESTRICTED   |                                                        |P=0.294      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  01/12/04                           EXPERIMENT: 92013 TEST: 06                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                    4-METHYLIMIDAZOLE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    1/50 (2%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |1/46.61      1/47.80      1/48.01      3/46.87      | 
|POLY-3 PERCENT (g) |                                                        |2.2%         2.1%         2.1%         6.4%         | 
|TERMINAL (d)       |                                                        |1/43 (2%)    1/40 (3%)    1/43 (2%)    2/40 (5%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      409          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.155      P=0.746      P=0.762      P=0.290      | 
|POLY 3             |                                                        |P=0.164      P=0.755N     P=0.754N     P=0.307      | 
|POLY 1.5           |                                                        |P=0.165      P=0.755N     P=0.755N     P=0.309      | 
|POLY 6             |                                                        |P=0.162      P=0.756N     P=0.754N     P=0.303      | 
|LOGISTIC REGRESSION|                                                        |P=0.155      P=0.746      P=0.762      P=0.278      | 
|COCH-ARM / FISHERS |                                                        |P=0.163      P=0.753N     P=0.753N     P=0.309      | 
|ORDER RESTRICTED   |                                                        |P=0.187      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    3/50 (6%)    1/50 (2%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |                                                        |2/46.61      3/47.80      1/48.01      5/46.05      | 
|POLY-3 PERCENT (g) |                                                        |4.3%         6.3%         2.1%         10.9%        | 
|TERMINAL (d)       |                                                        |2/43 (5%)    3/40 (8%)    1/43 (2%)    5/40 (13%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.143      P=0.467      P=0.500N     P=0.188      | 
|POLY 3             |                                                        |P=0.156      P=0.511      P=0.490N     P=0.211      | 
|POLY 1.5           |                                                        |P=0.159      P=0.511      P=0.491N     P=0.216      | 
|POLY 6             |                                                        |P=0.153      P=0.509      P=0.489N     P=0.205      | 
|LOGISTIC REGRESSION|                                                        |P=0.143      P=0.467      P=0.500N     P=0.188      | 
|COCH-ARM / FISHERS |                                                        |P=0.160      P=0.500      P=0.500N     P=0.218      | 
|ORDER RESTRICTED   |                                                        |P=0.136      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.