National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17675

TDMS Study 88004-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 08/14/03       
EXPERIMENT: 88004 TEST: 06                                                                                     TIME: 13:09:59       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: GRUMBEIN, SONDR                                                                                   CAS: 1321-74-0       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 08/14/03       
EXPERIMENT: 88004 TEST: 06                                                                                     TIME: 13:09:59       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: GRUMBEIN, SONDR                                                                                   CAS: 1321-74-0       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                     DIVINYLBENZENE                                                                               
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Eye: Cornea                            Mineralization                                                                               
Heart                                  Cardiomyopathy                                                                               
Kidney                                 Metaplasia Osseous                                                                           
                                       Nephropathy                                                                                  
Liver                                  Eosinophilic Focus                                                                           
                                       Vacuolization Cytoplasmic Focal                                                              
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
Lung: Bronchiole                       Hyperplasia Atypical                                                                         
Nose                                   Inflammation                                                                                 
Nose: Glands, Respiratory Epithelium   Metaplasia                                                                                   
Nose: Olfactory Epithelium             Atrophy                                                                                      
                                       Degeneration Hyaline                                                                         
Nose: Olfactory Epithelium, Respiratory Epithelium                                                                                  
                                       Metaplasia                                                                                   
Pancreas: Duct                         Cyst                                                                                         
Testes                                 Atrophy                                                                                      
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Hypertrophy                                                                                  
Eye: Cornea                            Mineralization                                                                               
Heart: Artery                          Inflammation Chronic                                                                         
Kidney                                 Nephropathy                                                                                  
Liver                                  Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
Lung: Bronchiole                       Hyperplasia Atypical                                                                         
Mesentery: Fat                         Necrosis                                                                                     
Nose                                   Inflammation                                                                                 
Nose: Glands, Respiratory Epithelium   Metaplasia                                                                                   
Nose: Olfactory Epithelium             Atrophy                                                                                      
                                       Degeneration Hyaline                                                                         
Nose: Olfactory Epithelium, Respiratory Epithelium                                                                                  
                                       Metaplasia                                                                                   
Pituitary Gland: Pars Distalis         Angiectasis                                                                                  
                                       Hyperplasia                                                                                  
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                      DIVINYLBENZENE   
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/49 (18%)   10/49 (20%)  6/50 (12%)   5/50 (10%)  |1/50 (2%)    2/50 (4%)    5/50 (10%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     9/45.45      10/45.74     6/46.79      5/47.18     |1/42.71      2/44.99      5/43.99      4/46.93      | 
|POLY-3 PERCENT (g) |     19.8%        21.9%        12.8%        10.6%       |2.3%         4.5%         11.4%        8.5%         | 
|TERMINAL (d)       |     9/41 (22%)   9/38 (24%)   5/42 (12%)   5/43 (12%)  |1/33 (3%)    2/35 (6%)    5/38 (13%)   4/42 (10%)   | 
|FIRST INCIDENCE    |     729 (T)      672          624          729 (T)     |731 (T)      731 (T)      731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.087N     P=0.431      P=0.270N     P=0.166N    |P=0.291      P=0.521      P=0.137      P=0.258      | 
|POLY 3             |     P=0.101N     P=0.506      P=0.266N     P=0.172N    |P=0.229      P=0.518      P=0.108      P=0.209      | 
|POLY 1.5           |     P=0.104N     P=0.502      P=0.270N     P=0.177N    |P=0.209      P=0.513      P=0.105      P=0.195      | 
|POLY 6             |     P=0.096N     P=0.511      P=0.260N     P=0.164N    |P=0.258      P=0.521      P=0.112      P=0.227      | 
|LOGISTIC REGRESSION|     P=0.094N     P=0.495      P=0.269N     P=0.166N    |P=0.291      P=0.521      P=0.137      P=0.258      | 
|COCH-ARM / FISHERS |     P=0.108N     P=0.500      P=0.274N     P=0.183N    |P=0.190      P=0.500      P=0.102      P=0.181      | 
|ORDER RESTRICTED   |     P=0.140N     (e)          (e)          (e)         |P=0.116      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     24/49 (49%)  25/49 (51%)  26/50 (52%)  24/50 (48%) |0/50 (0%)    3/50 (6%)    2/50 (4%)    8/50 (16%)   | 
|POLY-3 RATE (b)    |     24/45.98     25/46.04     26/46.55     24/47.18    |0/42.71      3/44.99      2/43.99      8/47.04      | 
|POLY-3 PERCENT (g) |     52.2%        54.3%        55.9%        50.9%       |0.0%         6.7%         4.6%         17.0%        | 
|TERMINAL (d)       |     23/41 (56%)  22/38 (58%)  25/42 (60%)  24/43 (56%) |0/33 (0%)    3/35 (9%)    2/38 (5%)    7/42 (17%)   | 
|FIRST INCIDENCE    |     565          641          696          729 (T)     |---          731 (T)      731 (T)      704          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.328N     P=0.363      P=0.467      P=0.490N    |P=0.005 **   P=0.131      P=0.270      P=0.013 *    | 
|POLY 3             |     P=0.441N     P=0.503      P=0.442      P=0.532N    |P=0.002 **   P=0.128      P=0.244      P=0.006 **   | 
|POLY 1.5           |     P=0.448N     P=0.497      P=0.448      P=0.538N    |P=0.002 **   P=0.126      P=0.241      P=0.005 **   | 
|POLY 6             |     P=0.427N     P=0.512      P=0.440      P=0.518N    |P=0.003 **   P=0.130      P=0.248      P=0.007 **   | 
|LOGISTIC REGRESSION|     P=0.363N     P=0.514      P=0.471      P=0.468N    |P=0.005 **   P=0.131      P=0.270      P=0.010 *    | 
|COCH-ARM / FISHERS |     P=0.457N     P=0.500      P=0.460      P=0.541N    |P=0.002 **   P=0.121      P=0.247      P=0.003 **   | 
|ORDER RESTRICTED   |     P=0.586N     (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/49 (4%)    0/50 (0%)    2/50 (4%)   |1/49 (2%)    1/50 (2%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/45.45      2/45.52      0/46.42      2/47.18     |1/41.71      1/44.99      0/43.89      2/46.93      | 
|POLY-3 PERCENT (g) |     2.2%         4.4%         0.0%         4.2%        |2.4%         2.2%         0.0%         4.3%         | 
|TERMINAL (d)       |     1/41 (2%)    2/38 (5%)    0/42 (0%)    2/43 (5%)   |1/32 (3%)    1/35 (3%)    0/38 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |731 (T)      731 (T)      ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.482      P=0.473      P=0.495N     P=0.517     |P=0.400      P=0.742N     P=0.466N     P=0.595      | 
|POLY 3             |     P=0.467      P=0.501      P=0.496N     P=0.513     |P=0.349      P=0.744N     P=0.490N     P=0.541      | 
|POLY 1.5           |     P=0.464      P=0.500      P=0.496N     P=0.510     |P=0.339      P=0.747N     P=0.493N     P=0.526      | 
|POLY 6             |     P=0.471      P=0.501      P=0.495N     P=0.518     |P=0.362      P=0.741N     P=0.485N     P=0.560      | 
|LOGISTIC REGRESSION|     P=0.482      P=0.473      (e)          P=0.517     |P=0.400      P=0.742N     (e)          P=0.595      | 
|COCH-ARM / FISHERS |     P=0.461      P=0.500      P=0.495N     P=0.508     |P=0.330      P=0.747N     P=0.500N     P=0.508      | 
|ORDER RESTRICTED   |     P=0.429      (e)          (e)          (e)         |P=0.310      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     1/45.69      2/46.49      0/46.42      0/47.18     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         4.3%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/41 (2%)    1/38 (3%)    0/42 (0%)    0/43 (0%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      556          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.220N     P=0.485      P=0.495N     P=0.490N    |                                                    | 
|POLY 3             |     P=0.224N     P=0.506      P=0.497N     P=0.494N    |                                                    | 
|POLY 1.5           |     P=0.226N     P=0.503      P=0.498N     P=0.496N    |                                                    | 
|POLY 6             |     P=0.222N     P=0.508      P=0.495N     P=0.490N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.240N     P=0.504      (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.228N     P=0.500      P=0.500N     P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.165N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/47 (0%)    0/47 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/45.34      0/44.53      0/44.18      0/47.18     |1/42.71      2/44.99      0/43.99      1/46.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         4.5%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/41 (0%)    0/38 (0%)    0/41 (0%)    0/43 (0%)   |1/33 (3%)    2/35 (6%)    0/38 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      731 (T)      ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.506N     P=0.521      P=0.472N     P=0.707N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.560N     P=0.518      P=0.494N     P=0.740N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.570N     P=0.513      P=0.497N     P=0.751N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.548N     P=0.521      P=0.490N     P=0.727N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.506N     P=0.521      (e)          P=0.707N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.584N     P=0.500      P=0.500N     P=0.747      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.366N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/47 (4%)    1/47 (2%)    1/50 (2%)   |1/50 (2%)    3/50 (6%)    0/50 (0%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     0/45.34      2/44.60      1/44.18      1/47.18     |1/42.71      3/44.99      0/43.99      3/47.76      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         2.3%         2.1%        |2.3%         6.7%         0.0%         6.3%         | 
|TERMINAL (d)       |     0/41 (0%)    1/38 (3%)    1/41 (2%)    1/43 (2%)   |1/33 (3%)    3/35 (9%)    0/38 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     ---          711          729 (T)      729 (T)     |731 (T)      731 (T)      ---          200          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.648      P=0.229      P=0.500      P=0.510     |P=0.392      P=0.326      P=0.472N     P=0.378      | 
|POLY 3             |     P=0.645      P=0.233      P=0.495      P=0.508     |P=0.347      P=0.324      P=0.494N     P=0.347      | 
|POLY 1.5           |     P=0.641      P=0.232      P=0.494      P=0.506     |P=0.329      P=0.319      P=0.497N     P=0.328      | 
|POLY 6             |     P=0.649      P=0.235      P=0.496      P=0.510     |P=0.368      P=0.327      P=0.490N     P=0.369      | 
|LOGISTIC REGRESSION|     P=0.645      P=0.233      P=0.500      P=0.510     |P=0.276      P=0.326      (e)          P=0.240      | 
|COCH-ARM / FISHERS |     P=0.638      P=0.237      P=0.490      P=0.505     |P=0.302      P=0.309      P=0.500N     P=0.301      | 
|ORDER RESTRICTED   |     P=0.264      (e)          (e)          (e)         |P=0.265      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/47 (0%)    0/47 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    6/49 (12%)   | 
|POLY-3 RATE (b)    |     0/45.34      0/44.53      0/44.18      2/47.18     |0/42.71      0/44.99      0/43.99      6/46.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.2%        |0.0%         0.0%         0.0%         12.8%        | 
|TERMINAL (d)       |     0/41 (0%)    0/38 (0%)    0/41 (0%)    2/43 (5%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    6/42 (14%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049 *    (e)          (e)          P=0.249     |P<0.001 **   (e)          (e)          P=0.034 *    | 
|POLY 3             |     P=0.046 *    (e)          (e)          P=0.246     |P<0.001 **   (e)          (e)          P=0.021 *    | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.244     |P<0.001 **   (e)          (e)          P=0.018 *    | 
|POLY 6             |     P=0.046 *    (e)          (e)          P=0.249     |P<0.001 **   (e)          (e)          P=0.025 *    | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.249     |(e)          (e)          (e)          P=0.034 *    | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.253     |P<0.001 **   (e)          (e)          P=0.012 *    | 
|ORDER RESTRICTED   |     P=0.033 *    (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/49 (4%)    3/50 (6%)    2/50 (4%)   |1/50 (2%)    4/50 (8%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/45.69      2/45.04      3/46.42      2/47.18     |1/42.99      4/45.64      2/44.07      3/46.93      | 
|POLY-3 PERCENT (g) |     4.4%         4.4%         6.5%         4.2%        |2.3%         8.8%         4.5%         6.4%         | 
|TERMINAL (d)       |     2/41 (5%)    2/38 (5%)    3/42 (7%)    2/43 (5%)   |0/33 (0%)    3/35 (9%)    1/38 (3%)    3/42 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |658          515          711          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.565N     P=0.667      P=0.511      P=0.678N    |P=0.547      P=0.199      P=0.535      P=0.386      | 
|POLY 3             |     P=0.584N     P=0.689      P=0.507      P=0.682N    |P=0.495      P=0.197      P=0.509      P=0.338      | 
|POLY 1.5           |     P=0.590N     P=0.687      P=0.504      P=0.687N    |P=0.474      P=0.192      P=0.505      P=0.323      | 
|POLY 6             |     P=0.576N     P=0.689      P=0.510      P=0.676N    |P=0.522      P=0.200      P=0.514      P=0.356      | 
|LOGISTIC REGRESSION|     P=0.565N     P=0.667      P=0.511      P=0.678N    |P=0.458      P=0.160      P=0.505      P=0.327      | 
|COCH-ARM / FISHERS |     P=0.599N     P=0.684      P=0.500      P=0.691N    |P=0.450      P=0.181      P=0.500      P=0.309      | 
|ORDER RESTRICTED   |     P=0.642      (e)          (e)          (e)         |P=0.301      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  5/49 (10%)   5/50 (10%)   5/50 (10%)  |3/50 (6%)    6/50 (12%)   1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     14/46.28     5/45.52      5/46.42      5/47.18     |3/43.23      6/45.73      1/44.07      1/46.93      | 
|POLY-3 PERCENT (g) |     30.3%        11.0%        10.8%        10.6%       |6.9%         13.1%        2.3%         2.1%         | 
|TERMINAL (d)       |     12/41 (29%)  5/38 (13%)   5/42 (12%)   5/43 (12%)  |2/33 (6%)    4/35 (11%)   0/38 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     620          729 (T)      729 (T)      729 (T)     |576          613          711          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.055N     P=0.030N*    P=0.019N*    P=0.016N*   |P=0.072N     P=0.272      P=0.273N     P=0.241N     | 
|POLY 3             |     P=0.063N     P=0.019N*    P=0.017N*    P=0.016N*   |P=0.084N     P=0.270      P=0.298N     P=0.277N     | 
|POLY 1.5           |     P=0.066N     P=0.020N*    P=0.018N*    P=0.017N*   |P=0.091N     P=0.262      P=0.301N     P=0.289N     | 
|POLY 6             |     P=0.060N     P=0.019N*    P=0.017N*    P=0.015N*   |P=0.076N     P=0.277      P=0.293N     P=0.261N     | 
|LOGISTIC REGRESSION|     P=0.059N     P=0.020N*    P=0.018N*    P=0.016N*   |P=0.100N     P=0.241      P=0.304N     P=0.304N     | 
|COCH-ARM / FISHERS |     P=0.073N     P=0.022N*    P=0.020N*    P=0.020N*   |P=0.102N     P=0.243      P=0.309N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.005N**   (e)          (e)          (e)         |P=0.084N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Artery                                                                                                                    | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.69      0/45.52      0/46.42      0/47.18     |2/42.71      0/44.99      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |4.7%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/41 (2%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |2/33 (6%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |731 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.488N     P=0.515N     P=0.495N     P=0.490N    |P=0.230N     P=0.225N     P=0.208N     P=0.187N     | 
|POLY 3             |     P=0.502N     P=0.501N     P=0.497N     P=0.494N    |P=0.266N     P=0.226N     P=0.230N     P=0.217N     | 
|POLY 1.5           |     P=0.500N     P=0.502N     P=0.498N     P=0.496N    |P=0.265N     P=0.229N     P=0.233N     P=0.226N     | 
|POLY 6             |     P=0.503N     P=0.500N     P=0.495N     P=0.490N    |P=0.266N     P=0.223N     P=0.226N     P=0.206N     | 
|LOGISTIC REGRESSION|     P=0.488N     (e)          (e)          (e)         |P=0.230N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.499N     P=0.505N     P=0.500N     P=0.500N    |P=0.262N     P=0.247N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.115N     (e)          (e)          (e)         |P=0.023N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.69      0/45.94      2/46.42      0/47.18     |0/41.88      0/44.99      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/41 (2%)    0/38 (0%)    2/42 (5%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.420N     P=0.515N     P=0.508      P=0.490N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.431N     P=0.499N     P=0.505      P=0.494N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.435N     P=0.500N     P=0.503      P=0.496N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.425N     P=0.499N     P=0.508      P=0.490N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.420N     (e)          P=0.508      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.441N     P=0.500N     P=0.500      P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.319N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.90      2/46.01      1/47.14      0/47.18     |0/41.88      0/44.99      1/44.64      0/46.93      | 
|POLY-3 PERCENT (g) |     2.2%         4.4%         2.1%         0.0%        |0.0%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/41 (0%)    1/38 (3%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     676          711          479          ---         |---          ---          512          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.229N     P=0.488      P=0.755N     P=0.486N    |P=0.778N     (e)          P=0.509      (e)          | 
|POLY 3             |     P=0.234N     P=0.501      P=0.755N     P=0.494N    |P=0.766N     (e)          P=0.513      (e)          | 
|POLY 1.5           |     P=0.236N     P=0.500      P=0.757N     P=0.497N    |P=0.772N     (e)          P=0.509      (e)          | 
|POLY 6             |     P=0.231N     P=0.500      P=0.753N     P=0.492N    |P=0.758N     (e)          P=0.517      (e)          | 
|LOGISTIC REGRESSION|     P=0.263N     P=0.500      P=0.729      P=0.513N    |P=0.741N     (e)          P=0.479      (e)          | 
|COCH-ARM / FISHERS |     P=0.238N     P=0.500      P=0.753N     P=0.500N    |P=0.778N     (e)          P=0.505      (e)          | 
|ORDER RESTRICTED   |     P=0.220N     (e)          (e)          (e)         |P=0.393      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.08      0/45.94      0/46.42      0/47.18     |0/41.88      2/45.74      2/45.55      0/46.93      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |0.0%         4.4%         4.4%         0.0%         | 
|TERMINAL (d)       |     0/41 (0%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     620          ---          ---          ---         |---          506          334          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.496N     P=0.491N     P=0.496N     P=0.491N    |P=0.363N     P=0.260      P=0.245      (e)          | 
|POLY 3             |     P=0.500N     P=0.501N     P=0.499N     P=0.495N    |P=0.336N     P=0.257      P=0.256      (e)          | 
|POLY 1.5           |     P=0.500N     P=0.500N     P=0.499N     P=0.497N    |P=0.351N     P=0.253      P=0.251      (e)          | 
|POLY 6             |     P=0.499N     P=0.502N     P=0.498N     P=0.493N    |P=0.317N     P=0.261      P=0.262      (e)          | 
|LOGISTIC REGRESSION|     P=0.531N     P=0.480N     P=0.526N     P=0.530N    |P=0.301N     P=0.158      P=0.176      (e)          | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.500N     P=0.500N    |P=0.370N     P=0.253      P=0.253      (e)          | 
|ORDER RESTRICTED   |     P=0.116N     (e)          (e)          (e)         |P=0.272N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   3/50 (6%)    5/50 (10%)   1/50 (2%)   |2/49 (4%)    3/50 (6%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     7/45.90      3/46.26      5/46.42      1/47.18     |2/42.96      3/45.01      3/43.99      1/46.93      | 
|POLY-3 PERCENT (g) |     15.3%        6.5%         10.8%        2.1%        |4.7%         6.7%         6.8%         2.1%         | 
|TERMINAL (d)       |     6/41 (15%)   2/38 (5%)    5/42 (12%)   1/43 (2%)   |0/33 (0%)    2/35 (6%)    3/38 (8%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     676          641          729 (T)      729 (T)     |352          725          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.042N*    P=0.187N     P=0.363N     P=0.029N*   |P=0.231N     P=0.527      P=0.545      P=0.447N     | 
|POLY 3             |     P=0.046N*    P=0.154N     P=0.371N     P=0.027N*   |P=0.269N     P=0.521      P=0.511      P=0.469N     | 
|POLY 1.5           |     P=0.047N*    P=0.156N     P=0.374N     P=0.029N*   |P=0.283N     P=0.519      P=0.509      P=0.481N     | 
|POLY 6             |     P=0.043N*    P=0.153N     P=0.369N     P=0.026N*   |P=0.249N     P=0.521      P=0.515      P=0.454N     | 
|LOGISTIC REGRESSION|     P=0.045N*    P=0.156N     P=0.361N     P=0.027N*   |P=0.302N     P=0.434      P=0.494      P=0.525N     | 
|COCH-ARM / FISHERS |     P=0.051N     P=0.159N     P=0.380N     P=0.030N*   |P=0.295N     P=0.510      P=0.510      P=0.492N     | 
|ORDER RESTRICTED   |     P=0.015N*    (e)          (e)          (e)         |P=0.314N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  43/50 (86%)  40/50 (80%)  34/50 (68%) |25/49 (51%)  31/50 (62%)  22/50 (44%)  17/50 (34%)  | 
|POLY-3 RATE (b)    |     45/48.46     43/48.07     40/49.25     34/49.11    |25/45.56     31/47.71     22/46.52     17/47.30     | 
|POLY-3 PERCENT (g) |     92.9%        89.5%        81.2%        69.2%       |54.9%        65.0%        47.3%        35.9%        | 
|TERMINAL (d)       |     39/41 (95%)  36/38 (95%)  34/42 (81%)  31/43 (72%) |16/33 (49%)  23/35 (66%)  16/38 (42%)  14/42 (33%)  | 
|FIRST INCIDENCE    |     517          556          479          452         |366          506          501          697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001N**   P=0.531      P=0.137N     P=0.005N**  |P=0.002N**   P=0.283      P=0.211N     P=0.017N*    | 
|POLY 3             |     P<0.001N**   P=0.403N     P=0.071N     P=0.002N**  |P=0.006N**   P=0.213      P=0.301N     P=0.050N     | 
|POLY 1.5           |     P<0.001N**   P=0.400N     P=0.090N     P=0.003N**  |P=0.008N**   P=0.207      P=0.307N     P=0.057N     | 
|POLY 6             |     P<0.001N**   P=0.403N     P=0.055N     P<0.001N**  |P=0.004N**   P=0.209      P=0.292N     P=0.041N*    | 
|LOGISTIC REGRESSION|     P<0.001N**   P=0.333N     P=0.113N     P=0.005N**  |P=0.008N**   P=0.195      P=0.306N     P=0.056N     | 
|COCH-ARM / FISHERS |     P=0.003N**   P=0.380N     P=0.131N     P=0.006N**  |P=0.010N*    P=0.184      P=0.309N     P=0.065N     | 
|ORDER RESTRICTED   |     P<0.001N**   (e)          (e)          (e)         |P=0.012N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.69      1/45.94      0/46.42      0/47.18     |0/41.88      0/44.99      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     4.4%         2.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/41 (5%)    1/38 (3%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.175N     P=0.527N     P=0.233N     P=0.228N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.184N     P=0.498N     P=0.234N     P=0.230N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.185N     P=0.499N     P=0.235N     P=0.233N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.182N     P=0.498N     P=0.232N     P=0.226N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.175N     P=0.527N     (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.186N     P=0.500N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.070N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    6/50 (12%)   7/50 (14%)   4/50 (8%)   |4/49 (8%)    2/50 (4%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/45.69      6/46.04      7/46.64      4/47.18     |4/42.26      2/45.69      0/43.99      2/46.93      | 
|POLY-3 PERCENT (g) |     6.6%         13.0%        15.0%        8.5%        |9.5%         4.4%         0.0%         4.3%         | 
|TERMINAL (d)       |     3/41 (7%)    5/38 (13%)   6/42 (14%)   4/43 (9%)   |3/33 (9%)    0/35 (0%)    0/38 (0%)    2/42 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      702          672          729 (T)     |625          515          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.455N     P=0.212      P=0.171      P=0.526     |P=0.335N     P=0.311N     P=0.053N     P=0.243N     | 
|POLY 3             |     P=0.487N     P=0.246      P=0.166      P=0.517     |P=0.391N     P=0.302N     P=0.055N     P=0.290N     | 
|POLY 1.5           |     P=0.497N     P=0.244      P=0.163      P=0.510     |P=0.399N     P=0.309N     P=0.056N     P=0.307N     | 
|POLY 6             |     P=0.473N     P=0.246      P=0.170      P=0.527     |P=0.380N     P=0.298N     P=0.053N     P=0.271N     | 
|LOGISTIC REGRESSION|     P=0.470N     P=0.237      P=0.167      P=0.526     |P=0.407N     P=0.347N     P=0.058N     P=0.295N     | 
|COCH-ARM / FISHERS |     P=0.512N     P=0.243      P=0.159      P=0.500     |P=0.404N     P=0.329N     P=0.056N     P=0.329N     | 
|ORDER RESTRICTED   |     P=0.305      (e)          (e)          (e)         |P=0.073N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   11/50 (22%)  6/50 (12%)   5/50 (10%)  |4/49 (8%)    2/50 (4%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     9/45.69      11/45.94     6/46.42      5/47.18     |4/42.16      2/45.01      3/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     19.7%        24.0%        12.9%        10.6%       |9.5%         4.4%         6.8%         0.0%         | 
|TERMINAL (d)       |     9/41 (22%)   11/38 (29%)  6/42 (14%)   5/43 (12%)  |3/33 (9%)    1/35 (3%)    3/38 (8%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |658          725          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.067N     P=0.325      P=0.268N     P=0.166N    |P=0.046N*    P=0.315N     P=0.434N     P=0.041N*    | 
|POLY 3             |     P=0.083N     P=0.406      P=0.275N     P=0.175N    |P=0.057N     P=0.307N     P=0.477N     P=0.048N*    | 
|POLY 1.5           |     P=0.089N     P=0.403      P=0.281N     P=0.183N    |P=0.062N     P=0.312N     P=0.481N     P=0.052N     | 
|POLY 6             |     P=0.077N     P=0.405      P=0.270N     P=0.165N    |P=0.051N     P=0.305N     P=0.470N     P=0.043N*    | 
|LOGISTIC REGRESSION|     P=0.067N     P=0.325      P=0.268N     P=0.166N    |P=0.052N     P=0.302N     P=0.465N     P=0.051N     | 
|COCH-ARM / FISHERS |     P=0.097N     P=0.402      P=0.288N     P=0.194N    |P=0.067N     P=0.329N     P=0.489N     P=0.056N     | 
|ORDER RESTRICTED   |     P=0.110N     (e)          (e)          (e)         |P=0.028N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   7/50 (14%)   0/50 (0%)    2/50 (4%)   |12/49 (24%)  8/50 (16%)   3/50 (6%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     8/46.08      7/45.94      0/46.42      2/47.18     |12/43.01     8/45.01      3/43.99      4/47.06      | 
|POLY-3 PERCENT (g) |     17.4%        15.2%        0.0%         4.2%        |27.9%        17.8%        6.8%         8.5%         | 
|TERMINAL (d)       |     7/41 (17%)   7/38 (18%)   0/42 (0%)    2/43 (5%)   |9/33 (27%)   7/35 (20%)   3/38 (8%)    3/42 (7%)    | 
|FIRST INCIDENCE    |     620          729 (T)      ---          729 (T)     |450          725          731 (T)      697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.023N*    P=0.557N     P=0.005N**   P=0.042N*   |P=0.014N*    P=0.188N     P=0.007N**   P=0.010N*    | 
|POLY 3             |     P=0.025N*    P=0.503N     P=0.003N**   P=0.041N*   |P=0.023N*    P=0.189N     P=0.008N**   P=0.015N*    | 
|POLY 1.5           |     P=0.026N*    P=0.502N     P=0.004N**   P=0.043N*   |P=0.028N*    P=0.193N     P=0.009N**   P=0.018N*    | 
|POLY 6             |     P=0.024N*    P=0.507N     P=0.003N**   P=0.039N*   |P=0.019N*    P=0.190N     P=0.008N**   P=0.011N*    | 
|LOGISTIC REGRESSION|     P=0.025N*    P=0.496N     P=0.005N**   P=0.042N*   |P=0.023N*    P=0.176N     P=0.010N*    P=0.020N*    | 
|COCH-ARM / FISHERS |     P=0.030N*    P=0.500N     P=0.003N**   P=0.046N*   |P=0.034N*    P=0.212N     P=0.010N*    P=0.024N*    | 
|ORDER RESTRICTED   |     P=0.006N**   (e)          (e)          (e)         |P=0.004N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |2/49 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.69      2/45.94      1/46.42      0/47.18     |2/42.08      1/45.56      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.2%         0.0%        |4.8%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/41 (0%)    2/38 (5%)    1/42 (2%)    0/43 (0%)   |1/33 (3%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |681          550          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.364N     P=0.222      P=0.505      (e)         |P=0.166N     P=0.476N     P=0.213N     P=0.189N     | 
|POLY 3             |     P=0.374N     P=0.238      P=0.503      (e)         |P=0.181N     P=0.472N     P=0.227N     P=0.214N     | 
|POLY 1.5           |     P=0.378N     P=0.238      P=0.502      (e)         |P=0.183N     P=0.478N     P=0.229N     P=0.222N     | 
|POLY 6             |     P=0.369N     P=0.238      P=0.505      (e)         |P=0.177N     P=0.469N     P=0.224N     P=0.204N     | 
|LOGISTIC REGRESSION|     (e)          P=0.222      P=0.505      (e)         |P=0.188N     P=0.537N     P=0.228N     P=0.222N     | 
|COCH-ARM / FISHERS |     P=0.383N     P=0.247      P=0.500      (e)         |P=0.184N     P=0.492N     P=0.242N     P=0.242N     | 
|ORDER RESTRICTED   |     P=0.320N     (e)          (e)          (e)         |P=0.060N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.34      0/45.94      1/46.42      0/47.18     |0/41.88      1/44.99      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         2.2%         0.0%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/41 (2%)    0/38 (0%)    1/42 (2%)    0/43 (0%)   |0/33 (0%)    1/35 (3%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     517          ---          729 (T)      ---         |---          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.266N     P=0.248N     P=0.494N     P=0.235N    |P=0.565N     P=0.512      (e)          (e)          | 
|POLY 3             |     P=0.270N     P=0.239N     P=0.499N     P=0.233N    |P=0.587N     P=0.514      (e)          (e)          | 
|POLY 1.5           |     P=0.273N     P=0.239N     P=0.500N     P=0.235N    |P=0.591N     P=0.512      (e)          (e)          | 
|POLY 6             |     P=0.267N     P=0.240N     P=0.499N     P=0.231N    |P=0.582N     P=0.516      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.295N     P=0.215N     P=0.523N     P=0.266N    |(e)          P=0.512      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.276N     P=0.247N     P=0.500N     P=0.247N    |P=0.600N     P=0.505      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.072N     (e)          (e)          (e)         |P=0.374N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/45.95      1/45.94      2/46.42      1/47.18     |0/41.88      0/44.99      0/43.99      1/46.93      | 
|POLY-3 PERCENT (g) |     4.4%         2.2%         4.3%         2.1%        |0.0%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     1/41 (2%)    1/38 (3%)    2/42 (5%)    1/43 (2%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     662          729 (T)      729 (T)      729 (T)     |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.449N     P=0.518N     P=0.685N     P=0.481N    |P=0.254      (e)          (e)          P=0.548      | 
|POLY 3             |     P=0.469N     P=0.500N     P=0.690N     P=0.491N    |P=0.234      (e)          (e)          P=0.523      | 
|POLY 1.5           |     P=0.473N     P=0.500N     P=0.691N     P=0.495N    |P=0.228      (e)          (e)          P=0.514      | 
|POLY 6             |     P=0.463N     P=0.502N     P=0.689N     P=0.486N    |P=0.242      (e)          (e)          P=0.533      | 
|LOGISTIC REGRESSION|     P=0.467N     P=0.500N     P=0.692N     P=0.500N    |(e)          (e)          (e)          P=0.548      | 
|COCH-ARM / FISHERS |     P=0.479N     P=0.500N     P=0.691N     P=0.500N    |P=0.222      (e)          (e)          P=0.505      | 
|ORDER RESTRICTED   |     P=0.431N     (e)          (e)          (e)         |P=0.142      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |1/49 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.69      2/46.38      2/47.51      2/48.39     |1/42.76      0/44.99      3/44.72      1/47.06      | 
|POLY-3 PERCENT (g) |     2.2%         4.3%         4.2%         4.1%        |2.3%         0.0%         6.7%         2.1%         | 
|TERMINAL (d)       |     1/41 (2%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    1/38 (3%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      641          479          452         |366          ---          512          697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.516      P=0.497      P=0.510      P=0.510     |P=0.634      P=0.496N     P=0.338      P=0.731N     | 
|POLY 3             |     P=0.526      P=0.505      P=0.514      P=0.520     |P=0.626      P=0.490N     P=0.321      P=0.739N     | 
|POLY 1.5           |     P=0.516      P=0.503      P=0.508      P=0.512     |P=0.609      P=0.491N     P=0.317      P=0.747N     | 
|POLY 6             |     P=0.538      P=0.508      P=0.520      P=0.529     |P=0.651      P=0.489N     P=0.329      P=0.727N     | 
|LOGISTIC REGRESSION|     P=0.412      P=0.500      P=0.449      P=0.427     |P=0.602      (e)          P=0.278      P=0.763      | 
|COCH-ARM / FISHERS |     P=0.500      P=0.500      P=0.500      P=0.500     |P=0.596      P=0.495N     P=0.316      P=0.747N     | 
|ORDER RESTRICTED   |     P=0.478      (e)          (e)          (e)         |P=0.282      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Tension Lipidosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |1/49 (2%)    5/50 (10%)   2/50 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/45.69      1/46.06      2/46.42      1/47.18     |1/41.97      5/45.10      2/43.99      4/47.91      | 
|POLY-3 PERCENT (g) |     4.4%         2.2%         4.3%         2.1%        |2.4%         11.1%        4.6%         8.4%         | 
|TERMINAL (d)       |     2/41 (5%)    0/38 (0%)    2/42 (5%)    1/43 (2%)   |0/33 (0%)    3/35 (9%)    2/38 (5%)    3/42 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      697          729 (T)      729 (T)     |710          709          731 (T)      200          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.450N     P=0.515N     P=0.686N     P=0.483N    |P=0.449      P=0.126      P=0.548      P=0.244      | 
|POLY 3             |     P=0.468N     P=0.497N     P=0.688N     P=0.489N    |P=0.405      P=0.118      P=0.516      P=0.222      | 
|POLY 1.5           |     P=0.473N     P=0.499N     P=0.690N     P=0.494N    |P=0.380      P=0.115      P=0.513      P=0.207      | 
|POLY 6             |     P=0.463N     P=0.496N     P=0.686N     P=0.483N    |P=0.434      P=0.120      P=0.522      P=0.239      | 
|LOGISTIC REGRESSION|     P=0.459N     P=0.498N     P=0.686N     P=0.483N    |P=0.333      P=0.121      P=0.526      P=0.155      | 
|COCH-ARM / FISHERS |     P=0.479N     P=0.500N     P=0.691N     P=0.500N    |P=0.343      P=0.107      P=0.508      P=0.187      | 
|ORDER RESTRICTED   |     P=0.428N     (e)          (e)          (e)         |P=0.204      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Vacuolization Cytoplasmic Focal                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/45.69      0/45.94      0/46.42      0/47.18     |0/41.88      0/44.99      0/43.99      1/47.91      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     2/41 (5%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          200          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.251N     P=0.255N     P=0.233N     P=0.228N    |P=0.221      (e)          (e)          P=0.500      | 
|POLY 3             |     P=0.261N     P=0.236N     P=0.234N     P=0.230N    |P=0.237      (e)          (e)          P=0.527      | 
|POLY 1.5           |     P=0.261N     P=0.237N     P=0.235N     P=0.233N    |P=0.231      (e)          (e)          P=0.518      | 
|POLY 6             |     P=0.260N     P=0.236N     P=0.232N     P=0.226N    |P=0.246      (e)          (e)          P=0.537      | 
|LOGISTIC REGRESSION|     P=0.251N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.262N     P=0.247N     P=0.247N     P=0.247N    |P=0.222      (e)          (e)          P=0.505      | 
|ORDER RESTRICTED   |     P=0.027N*    (e)          (e)          (e)         |P=0.146      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    5/49 (10%)   5/49 (10%)   7/49 (14%)  |4/50 (8%)    3/50 (6%)    4/50 (8%)    8/49 (16%)   | 
|POLY-3 RATE (b)    |     1/45.45      5/45.84      5/46.05      7/46.83     |4/43.19      3/44.99      4/43.99      8/46.92      | 
|POLY-3 PERCENT (g) |     2.2%         10.9%        10.9%        15.0%       |9.3%         6.7%         9.1%         17.1%        | 
|TERMINAL (d)       |     1/41 (2%)    4/38 (11%)   5/42 (12%)   6/43 (14%)  |2/33 (6%)    3/35 (9%)    4/38 (11%)   6/42 (14%)   | 
|FIRST INCIDENCE    |     729 (T)      641          729 (T)      719         |660          731 (T)      731 (T)      697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093      P=0.092      P=0.109      P=0.040 *   |P=0.136      P=0.472N     P=0.578N     P=0.316      | 
|POLY 3             |     P=0.075      P=0.103      P=0.104      P=0.033 *   |P=0.075      P=0.478N     P=0.634N     P=0.220      | 
|POLY 1.5           |     P=0.072      P=0.102      P=0.103      P=0.032 *   |P=0.065      P=0.483N     P=0.637N     P=0.197      | 
|POLY 6             |     P=0.080      P=0.104      P=0.106      P=0.035 *   |P=0.090      P=0.478N     P=0.628N     P=0.248      | 
|LOGISTIC REGRESSION|     P=0.081      P=0.103      P=0.109      P=0.039 *   |P=0.092      P=0.472N     P=0.625N     P=0.213      | 
|COCH-ARM / FISHERS |     P=0.068      P=0.102      P=0.102      P=0.030 *   |P=0.056      P=0.500N     P=0.643N     P=0.168      | 
|ORDER RESTRICTED   |     P=0.026 *    (e)          (e)          (e)         |P=0.122      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    4/49 (8%)    5/49 (10%)   1/49 (2%)   |3/50 (6%)    6/50 (12%)   9/50 (18%)   17/49 (35%)  | 
|POLY-3 RATE (b)    |     2/45.45      4/45.52      5/46.05      1/46.79     |3/43.00      6/44.99      9/43.99      17/48.75     | 
|POLY-3 PERCENT (g) |     4.4%         8.8%         10.9%        2.1%        |7.0%         13.3%        20.5%        34.9%        | 
|TERMINAL (d)       |     2/41 (5%)    4/38 (11%)   5/42 (12%)   1/43 (2%)   |1/33 (3%)    6/35 (17%)   9/38 (24%)   13/42 (31%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |676          731 (T)      731 (T)      200          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.204N     P=0.302      P=0.226      P=0.483N    |P<0.001 **   P=0.277      P=0.100      P=0.005 **   | 
|POLY 3             |     P=0.219N     P=0.338      P=0.221      P=0.490N    |P<0.001 **   P=0.264      P=0.063      P<0.001 **   | 
|POLY 1.5           |     P=0.226N     P=0.337      P=0.219      P=0.494N    |P<0.001 **   P=0.259      P=0.062      P<0.001 **   | 
|POLY 6             |     P=0.210N     P=0.338      P=0.224      P=0.484N    |P<0.001 **   P=0.265      P=0.065      P=0.002 **   | 
|LOGISTIC REGRESSION|     P=0.204N     P=0.302      P=0.226      P=0.483N    |P<0.001 **   P=0.273      P=0.074      P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.234N     P=0.339      P=0.218      P=0.500N    |P<0.001 **   P=0.243      P=0.061      P<0.001 **   | 
|ORDER RESTRICTED   |     P=0.196N     (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Bronchiole                                                                                                                 | 
|     Hyperplasia Atypical                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    38/49 (78%)  46/49 (94%)  46/49 (94%) |0/50 (0%)    39/50 (78%)  45/50 (90%)  48/49 (98%)  | 
|POLY-3 RATE (b)    |     0/45.45      38/46.48     46/48.63     46/48.04    |0/42.71      39/46.37     45/47.11     48/49.00     | 
|POLY-3 PERCENT (g) |     0.0%         81.8%        94.6%        95.8%       |0.0%         84.1%        95.5%        98.0%        | 
|TERMINAL (d)       |     0/41 (0%)    34/38 (90%)  40/42 (95%)  43/43 (100%)|0/33 (0%)    35/35 (100%) 38/38 (100%) 41/42 (98%)  | 
|FIRST INCIDENCE    |     ---          600          479          452         |---          537          359          200          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/11 (91%)  4/4 (100%)   4/4 (100%)   5/5 (100%)  |17/17 (100%) 15/16 (94%)  3/4 (75%)    5/5 (100%)   | 
|POLY-3 RATE (b)    |     10/11.00     4/4.00       4/4.00       5/5.00      |17/17.00     15/15.43     3/4.00       5/5.00       | 
|POLY-3 PERCENT (g) |     90.9%        100.0%       100.0%       100.0%      |100.0%       97.2%        75.0%        100.0%       | 
|TERMINAL (d)       |     8/9 (89%)    4/4 (100%)   4/4 (100%)   4/4 (100%)  |12/12 (100%) 9/9 (100%)   3/4 (75%)    4/4 (100%)   | 
|FIRST INCIDENCE    |     536          729 (T)      729 (T)      598         |586          515          731 (T)      697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.581      P=0.419N     P=0.412N     P=0.610N    |P=0.032N*    P=0.547      P=0.009N**   (e)          | 
|POLY 3             |     P=0.574      P=0.697      P=0.697      P=0.654     |P=0.807N     P=0.899N     P=0.193N     (e)          | 
|POLY 1.5           |     P=0.574      P=0.697      P=0.697      P=0.654     |P=0.796N     P=0.687N     P=0.193N     (e)          | 
|POLY 6             |     P=0.574      P=0.697      P=0.697      P=0.654     |P=0.810N     P=1.000N     P=0.193N     (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.419N     P=0.412N     (e)         |P=0.756N     P=0.908N     P=0.009N**   (e)          | 
|COCH-ARM / FISHERS |     P=0.579      P=0.733      P=0.733      P=0.688     |P=0.773N     P=0.485N     P=0.190N     (e)          | 
|ORDER RESTRICTED   |     P=0.326      (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    47/50 (94%)  49/49 (100%) 49/50 (98%) |1/50 (2%)    50/50 (100%) 49/50 (98%)  49/49 (100%) | 
|POLY-3 RATE (b)    |     3/45.69      47/48.94     49/49.00     49/50.00    |1/42.71      50/50.00     49/49.34     49/49.00     | 
|POLY-3 PERCENT (g) |     6.6%         96.0%        100.0%       98.0%       |2.3%         100.0%       99.3%        100.0%       | 
|TERMINAL (d)       |     3/41 (7%)    38/38 (100%) 42/42 (100%) 42/43 (98%) |1/33 (3%)    35/35 (100%) 38/38 (100%) 42/42 (100%) | 
|FIRST INCIDENCE    |     729 (T)      543          479          452         |731 (T)      506          334          200          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Glands, Respiratory Epithelium                                                                                             | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  50/50 (100%) 49/49 (100%) 50/50 (100%)|3/50 (6%)    50/50 (100%) 50/50 (100%) 49/49 (100%) | 
|POLY-3 RATE (b)    |     12/46.08     50/50.00     49/49.00     50/50.00    |3/42.71      50/50.00     50/50.00     49/49.00     | 
|POLY-3 PERCENT (g) |     26.0%        100.0%       100.0%       100.0%      |7.0%         100.0%       100.0%       100.0%       | 
|TERMINAL (d)       |     11/41 (27%)  38/38 (100%) 42/42 (100%) 43/43 (100%)|3/33 (9%)    35/35 (100%) 38/38 (100%) 42/42 (100%) | 
|FIRST INCIDENCE    |     620          338          479          452         |731 (T)      506          334          200          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  0/50 (0%)    0/49 (0%)    0/50 (0%)   |8/50 (16%)   0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     14/46.08     0/45.94      0/46.05      0/47.18     |8/43.38      0/44.99      0/43.99      0/46.76      | 
|POLY-3 PERCENT (g) |     30.4%        0.0%         0.0%         0.0%        |18.4%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     13/41 (32%)  0/38 (0%)    0/42 (0%)    0/43 (0%)   |6/33 (18%)   0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     620          ---          ---          ---         |596          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**  |P=0.008N**   P=0.004N**   P=0.003N**   P=0.002N**   | 
|POLY 3             |     P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**  |P=0.008N**   P=0.003N**   P=0.003N**   P=0.002N**   | 
|POLY 1.5           |     P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**  |P=0.009N**   P=0.003N**   P=0.003N**   P=0.003N**   | 
|POLY 6             |     P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**  |P=0.007N**   P=0.003N**   P=0.003N**   P=0.002N**   | 
|LOGISTIC REGRESSION|     P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**  |P=0.011N*    P=0.004N**   P=0.004N**   P=0.004N**   | 
|COCH-ARM / FISHERS |     P<0.001N**   P<0.001N**   P<0.001N**   P<0.001N**  |P=0.012N*    P=0.003N**   P=0.003N**   P=0.003N**   | 
|ORDER RESTRICTED   |     P<0.001N**   (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   50/50 (100%) 48/49 (98%)  11/50 (22%) |2/50 (4%)    50/50 (100%) 40/50 (80%)  8/49 (16%)   | 
|POLY-3 RATE (b)    |     5/45.69      50/50.00     48/49.00     11/47.99    |2/43.17      50/50.00     40/50.00     8/47.74      | 
|POLY-3 PERCENT (g) |     10.9%        100.0%       98.0%        22.9%       |4.6%         100.0%       80.0%        16.8%        | 
|TERMINAL (d)       |     5/41 (12%)   38/38 (100%) 41/42 (98%)  9/43 (21%)  |1/33 (3%)    35/35 (100%) 28/38 (74%)  7/42 (17%)   | 
|FIRST INCIDENCE    |     729 (T)      338          479          452         |596          506          334          200          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001N**   P<0.001 **   P<0.001 **   P=0.106     |P<0.001N**   P<0.001 **   P<0.001 **   P=0.093      | 
|POLY 3             |     P<0.001N**   P<0.001 **   P<0.001 **   P=0.102     |P<0.001N**   P<0.001 **   P<0.001 **   P=0.064      | 
|POLY 1.5           |     P<0.001N**   P<0.001 **   P<0.001 **   P=0.095     |P<0.001N**   P<0.001 **   P<0.001 **   P=0.055      | 
|POLY 6             |     P<0.001N**   P<0.001 **   P<0.001 **   P=0.110     |P<0.001N**   P<0.001 **   P<0.001 **   P=0.076      | 
|LOGISTIC REGRESSION|     P<0.001N**   P<0.001 **   P<0.001 **   P=0.090     |P<0.001N**   P<0.001 **   P<0.001 **   P=0.031 *    | 
|COCH-ARM / FISHERS |     P<0.001N**   P<0.001 **   P<0.001 **   P=0.086     |P<0.001N**   P<0.001 **   P<0.001 **   P=0.043 *    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium, Respiratory Epithelium                                                                               | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    50/50 (100%) 49/49 (100%) 50/50 (100%)|0/50 (0%)    50/50 (100%) 50/50 (100%) 49/49 (100%) | 
|POLY-3 RATE (b)    |     1/45.69      50/50.00     49/49.00     50/50.00    |0/42.71      50/50.00     50/50.00     49/49.00     | 
|POLY-3 PERCENT (g) |     2.2%         100.0%       100.0%       100.0%      |0.0%         100.0%       100.0%       100.0%       | 
|TERMINAL (d)       |     1/41 (2%)    38/38 (100%) 42/42 (100%) 43/43 (100%)|0/33 (0%)    35/35 (100%) 38/38 (100%) 42/42 (100%) | 
|FIRST INCIDENCE    |     729 (T)      338          479          452         |---          506          334          200          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/48 (4%)    3/50 (6%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/41.05      3/44.99      0/42.99      0/45.93      | 
|POLY-3 PERCENT (g) |                                                        |4.9%         6.7%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |1/33 (3%)    3/35 (9%)    0/37 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |                                                        |709          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.080N     P=0.529      P=0.213N     P=0.195N     | 
|POLY 3             |                                                        |P=0.090N     P=0.542      P=0.227N     P=0.213N     | 
|POLY 1.5           |                                                        |P=0.094N     P=0.536      P=0.229N     P=0.221N     | 
|POLY 6             |                                                        |P=0.085N     P=0.544      P=0.224N     P=0.203N     | 
|LOGISTIC REGRESSION|                                                        |P=0.082N     P=0.548      P=0.224N     P=0.207N     | 
|COCH-ARM / FISHERS |                                                        |P=0.100N     P=0.520      P=0.242N     P=0.242N     | 
|ORDER RESTRICTED   |                                                        |P=0.078N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |9/48 (19%)   14/50 (28%)  10/49 (20%)  9/49 (18%)   | 
|POLY-3 RATE (b)    |                                                        |9/41.82      14/46.03     10/44.32     9/45.93      | 
|POLY-3 PERCENT (g) |                                                        |21.5%        30.4%        22.6%        19.6%        | 
|TERMINAL (d)       |                                                        |7/33 (21%)   10/35 (29%)  7/37 (19%)   9/41 (22%)   | 
|FIRST INCIDENCE    |                                                        |450          515          501          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.184N     P=0.224      P=0.597N     P=0.414N     | 
|POLY 3             |                                                        |P=0.273N     P=0.240      P=0.557      P=0.516N     | 
|POLY 1.5           |                                                        |P=0.303N     P=0.228      P=0.541      P=0.548N     | 
|POLY 6             |                                                        |P=0.235N     P=0.250      P=0.578      P=0.476N     | 
|LOGISTIC REGRESSION|                                                        |P=0.299N     P=0.226      P=0.527      P=0.518N     | 
|COCH-ARM / FISHERS |                                                        |P=0.332N     P=0.200      P=0.520      P=0.584N     | 
|ORDER RESTRICTED   |                                                        |P=0.374N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/50 (0%)    0/50 (0%)   |0/48 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.45      0/45.42      0/46.42      0/47.18     |0/41.16      2/45.79      1/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.4%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/41 (0%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    1/38 (3%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          515          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.348N     P=0.264      P=0.528      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.348N     P=0.261      P=0.513      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.360N     P=0.257      P=0.511      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.334N     P=0.264      P=0.516      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.383N     P=0.158      P=0.528      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.377N     P=0.258      P=0.510      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.322N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/48 (0%)    0/50 (0%)    0/50 (0%)   |0/48 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.45      0/45.42      0/46.42      0/47.18     |0/41.16      0/44.99      2/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.6%         0.0%         | 
|TERMINAL (d)       |     2/41 (5%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    2/38 (5%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.251N     P=0.255N     P=0.233N     P=0.228N    |P=0.625N     (e)          P=0.270      (e)          | 
|POLY 3             |     P=0.259N     P=0.237N     P=0.232N     P=0.229N    |P=0.649N     (e)          P=0.252      (e)          | 
|POLY 1.5           |     P=0.258N     P=0.239N     P=0.233N     P=0.231N    |P=0.660N     (e)          P=0.250      (e)          | 
|POLY 6             |     P=0.259N     P=0.236N     P=0.232N     P=0.226N    |P=0.633N     (e)          P=0.255      (e)          | 
|LOGISTIC REGRESSION|     P=0.251N     (e)          (e)          (e)         |(e)          (e)          P=0.270      (e)          | 
|COCH-ARM / FISHERS |     P=0.258N     P=0.253N     P=0.242N     P=0.242N    |P=0.671N     (e)          P=0.258      (e)          | 
|ORDER RESTRICTED   |     P=0.027N*    (e)          (e)          (e)         |P=0.261      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/47 (0%)    0/47 (0%)    0/46 (0%)   |3/47 (6%)    0/50 (0%)    0/49 (0%)    0/45 (0%)    | 
|POLY-3 RATE (b)    |     0/43.90      0/44.39      0/44.18      0/44.12     |3/39.88      0/44.99      0/42.99      0/42.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |7.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/38 (0%)    0/41 (0%)    0/41 (0%)   |3/31 (10%)   0/35 (0%)    0/37 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.129N     P=0.100N     P=0.091N     P=0.087N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.156N     P=0.098N     P=0.105N     P=0.106N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.156N     P=0.101N     P=0.108N     P=0.115N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.155N     P=0.096N     P=0.102N     P=0.097N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.129N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.156N     P=0.110N     P=0.113N     P=0.129N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.006N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    1/47 (2%)    2/47 (4%)    1/46 (2%)   |8/47 (17%)   16/50 (32%)  6/49 (12%)   5/45 (11%)   | 
|POLY-3 RATE (b)    |     2/43.90      1/44.39      2/44.18      1/44.12     |8/40.15      16/46.07     6/43.59      5/42.77      | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         4.5%         2.3%        |19.9%        34.7%        13.8%        11.7%        | 
|TERMINAL (d)       |     2/40 (5%)    1/38 (3%)    2/41 (5%)    1/41 (2%)   |7/31 (23%)   12/35 (34%)  5/37 (14%)   4/38 (11%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |660          613          536          729          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.462N     P=0.518N     P=0.686N     P=0.491N    |P=0.023N*    P=0.093      P=0.273N     P=0.161N     | 
|POLY 3             |     P=0.481N     P=0.496N     P=0.692N     P=0.498N    |P=0.036N*    P=0.097      P=0.323N     P=0.234N     | 
|POLY 1.5           |     P=0.486N     P=0.500N     P=0.692      P=0.505N    |P=0.046N*    P=0.087      P=0.335N     P=0.263N     | 
|POLY 6             |     P=0.475N     P=0.494N     P=0.688N     P=0.491N    |P=0.027N*    P=0.107      P=0.307N     P=0.204N     | 
|LOGISTIC REGRESSION|     P=0.462N     P=0.518N     P=0.686N     P=0.491N    |P=0.042N*    P=0.093      P=0.328N     P=0.187N     | 
|COCH-ARM / FISHERS |     P=0.492N     P=0.508N     P=0.684      P=0.516N    |P=0.065N     P=0.070      P=0.354N     P=0.305N     | 
|ORDER RESTRICTED   |     P=0.441N     (e)          (e)          (e)         |P=0.048N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    2/50 (4%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     1/45.69      3/45.94      2/46.42      1/47.18     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         6.5%         4.3%         2.1%        |                                                    | 
|TERMINAL (d)       |     1/41 (2%)    3/38 (8%)    2/42 (5%)    1/43 (2%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.391N     P=0.278      P=0.508      P=0.751N    |                                                    | 
|POLY 3             |     P=0.409N     P=0.307      P=0.505      P=0.753N    |                                                    | 
|POLY 1.5           |     P=0.415N     P=0.306      P=0.503      P=0.756N    |                                                    | 
|POLY 6             |     P=0.401N     P=0.307      P=0.508      P=0.750N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.391N     P=0.278      P=0.508      P=0.751N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.422N     P=0.309      P=0.500      P=0.753N    |                                                    | 
|ORDER RESTRICTED   |     P=0.452N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/45.69      0/45.94      2/46.42      0/47.18     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/41 (0%)    0/38 (0%)    2/42 (5%)    0/43 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.657N     (e)          P=0.244      (e)         |                                                    | 
|POLY 3             |     P=0.666N     (e)          P=0.241      (e)         |                                                    | 
|POLY 1.5           |     P=0.670N     (e)          P=0.239      (e)         |                                                    | 
|POLY 6             |     P=0.661N     (e)          P=0.242      (e)         |                                                    | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.244      (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.675N     (e)          P=0.247      (e)         |                                                    | 
|ORDER RESTRICTED   |     P=0.250      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |3/50 (6%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/46.50      1/45.94      0/46.42      2/47.74     |3/44.03      2/45.29      0/43.99      1/47.06      | 
|POLY-3 PERCENT (g) |     6.5%         2.2%         0.0%         4.2%        |6.8%         4.4%         0.0%         2.1%         | 
|TERMINAL (d)       |     1/41 (2%)    1/38 (3%)    0/42 (0%)    1/43 (2%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     609          729 (T)      ---          558         |479          656          ---          697          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.624N     P=0.315N     P=0.121N     P=0.484N    |P=0.242N     P=0.475N     P=0.116N     P=0.260N     | 
|POLY 3             |     P=0.636N     P=0.310N     P=0.119N     P=0.488N    |P=0.268N     P=0.487N     P=0.119N     P=0.282N     | 
|POLY 1.5           |     P=0.640N     P=0.308N     P=0.119N     P=0.493N    |P=0.274N     P=0.490N     P=0.119N     P=0.293N     | 
|POLY 6             |     P=0.631N     P=0.314N     P=0.120N     P=0.483N    |P=0.258N     P=0.487N     P=0.118N     P=0.268N     | 
|LOGISTIC REGRESSION|     P=0.613      P=0.301N     P=0.130N     P=0.555N    |P=0.286N     P=0.603N     P=0.129N     P=0.334N     | 
|COCH-ARM / FISHERS |     P=0.645      P=0.309N     P=0.121N     P=0.500N    |P=0.280N     P=0.500N     P=0.121N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.180N     (e)          (e)          (e)         |P=0.096N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/48 (0%)    1/50 (2%)    0/50 (0%)   |3/49 (6%)    3/50 (6%)    3/49 (6%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     1/45.87      0/45.42      1/46.42      0/47.18     |3/42.34      3/45.80      3/44.40      1/46.87      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.2%         0.0%        |7.1%         6.6%         6.8%         2.1%         | 
|TERMINAL (d)       |     0/41 (0%)    0/38 (0%)    1/42 (2%)    0/43 (0%)   |1/33 (3%)    1/35 (3%)    2/38 (5%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     609          ---          729 (T)      ---         |625          506          334          704          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.454N     P=0.496N     P=0.758N     P=0.496N    |P=0.170N     P=0.622N     P=0.617N     P=0.238N     | 
|POLY 3             |     P=0.458N     P=0.502N     P=0.758N     P=0.494N    |P=0.190N     P=0.626N     P=0.640N     P=0.270N     | 
|POLY 1.5           |     P=0.458N     P=0.503N     P=0.757N     P=0.495N    |P=0.203N     P=0.633N     P=0.648N     P=0.285N     | 
|POLY 6             |     P=0.456N     P=0.502N     P=0.759N     P=0.493N    |P=0.174N     P=0.622N     P=0.633N     P=0.254N     | 
|LOGISTIC REGRESSION|     P=0.447N     P=0.643N     P=0.754N     P=0.476N    |P=0.240N     P=0.640      P=0.645      P=0.306N     | 
|COCH-ARM / FISHERS |     P=0.458N     P=0.505N     P=0.747N     P=0.495N    |P=0.218N     P=0.651N     P=0.661N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.246N     (e)          (e)          (e)         |P=0.249N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    4/50 (8%)    2/49 (4%)    4/50 (8%)   |3/50 (6%)    5/50 (10%)   0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.45      4/47.16      2/46.78      4/47.18     |3/44.63      5/45.81      0/43.99      1/46.93      | 
|POLY-3 PERCENT (g) |     2.2%         8.5%         4.3%         8.5%        |6.7%         10.9%        0.0%         2.1%         | 
|TERMINAL (d)       |     1/41 (2%)    2/38 (5%)    0/42 (0%)    4/43 (9%)   |0/33 (0%)    1/35 (3%)    0/38 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      338          572          729 (T)     |366          550          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.295      P=0.173      P=0.511      P=0.194     |P=0.106N     P=0.400      P=0.121N     P=0.269N     | 
|POLY 3             |     P=0.275      P=0.190      P=0.510      P=0.190     |P=0.115N     P=0.371      P=0.121N     P=0.288N     | 
|POLY 1.5           |     P=0.272      P=0.189      P=0.506      P=0.188     |P=0.121N     P=0.366      P=0.121N     P=0.297N     | 
|POLY 6             |     P=0.280      P=0.191      P=0.516      P=0.194     |P=0.107N     P=0.376      P=0.120N     P=0.273N     | 
|LOGISTIC REGRESSION|     P=0.240      P=0.221      P=0.487      P=0.194     |P=0.127N     P=0.188      P=0.125N     P=0.331N     | 
|COCH-ARM / FISHERS |     P=0.269      P=0.187      P=0.500      P=0.187     |P=0.128N     P=0.357      P=0.121N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.156      (e)          (e)          (e)         |P=0.061N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Acute                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.45      2/45.94      0/46.05      1/47.74     |0/42.71      0/44.99      0/43.99      0/46.93      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         2.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/41 (0%)    2/38 (5%)    0/42 (0%)    0/43 (0%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          558         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.631      P=0.222      (e)          P=0.504     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.628      P=0.240      (e)          P=0.510     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.624      P=0.240      (e)          P=0.507     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.633      P=0.239      (e)          P=0.513     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.608      P=0.222      (e)          P=0.566     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.620      P=0.253      (e)          P=0.505     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.326      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/49 (0%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/45.45      1/46.26      0/46.05      3/47.18     |1/42.91      0/44.99      0/43.99      2/46.94      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         0.0%         6.4%        |2.3%         0.0%         0.0%         4.3%         | 
|TERMINAL (d)       |     1/41 (2%)    0/38 (0%)    0/42 (0%)    3/43 (7%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    1/42 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      639          ---          729 (T)     |681          ---          ---          729          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.141      P=0.757      P=0.495N     P=0.322     |P=0.238      P=0.485N     P=0.485N     P=0.582      | 
|POLY 3             |     P=0.129      P=0.757N     P=0.497N     P=0.319     |P=0.194      P=0.491N     P=0.495N     P=0.531      | 
|POLY 1.5           |     P=0.128      P=0.757N     P=0.499N     P=0.316     |P=0.189      P=0.493N     P=0.497N     P=0.517      | 
|POLY 6             |     P=0.131      P=0.756N     P=0.496N     P=0.324     |P=0.203      P=0.489N     P=0.492N     P=0.548      | 
|LOGISTIC REGRESSION|     P=0.127      P=0.752N     (e)          P=0.322     |P=0.199      P=0.506N     P=0.501N     P=0.525      | 
|COCH-ARM / FISHERS |     P=0.126      P=0.747N     P=0.500N     P=0.316     |P=0.186      P=0.500N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.110      (e)          (e)          (e)         |P=0.151      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    1/49 (2%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/45.45      2/46.01      1/46.56      1/47.18     |0/42.71      1/45.56      1/44.59      0/46.93      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.2%         2.1%        |0.0%         2.2%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/41 (0%)    1/38 (3%)    0/42 (0%)    1/43 (2%)   |0/33 (0%)    0/35 (0%)    0/38 (0%)    0/42 (0%)    | 
|FIRST INCIDENCE    |     ---          711          572          729 (T)     |---          550          536          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.643      P=0.229      P=0.504      P=0.510     |P=0.531N     P=0.509      P=0.504      (e)          | 
|POLY 3             |     P=0.636      P=0.240      P=0.505      P=0.507     |P=0.512N     P=0.513      P=0.509      (e)          | 
|POLY 1.5           |     P=0.633      P=0.240      P=0.503      P=0.506     |P=0.523N     P=0.509      P=0.505      (e)          | 
|POLY 6             |     P=0.641      P=0.239      P=0.508      P=0.510     |P=0.499N     P=0.516      P=0.514      (e)          | 
|LOGISTIC REGRESSION|     P=0.621      P=0.239      P=0.511      P=0.510     |P=0.496N     P=0.359      P=0.480      (e)          | 
|COCH-ARM / FISHERS |     P=0.630      P=0.253      P=0.500      P=0.505     |P=0.536N     P=0.500      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.274      (e)          (e)          (e)         |P=0.397N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.34      0/45.94      0/46.42      0/47.18     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/41 (2%)    0/38 (0%)    0/42 (0%)    0/43 (0%)   |                                                    | 
|FIRST INCIDENCE    |     517          ---          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.257N     P=0.248N     P=0.237N     P=0.235N    |                                                    | 
|POLY 3             |     P=0.259N     P=0.239N     P=0.237N     P=0.233N    |                                                    | 
|POLY 1.5           |     P=0.259N     P=0.239N     P=0.237N     P=0.235N    |                                                    | 
|POLY 6             |     P=0.257N     P=0.240N     P=0.236N     P=0.231N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.287N     P=0.215N     P=0.260N     P=0.266N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.262N     P=0.247N     P=0.247N     P=0.247N    |                                                    | 
|ORDER RESTRICTED   |     P=0.028N*    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/49 (4%)    1/50 (2%)    0/50 (0%)   |1/49 (2%)    2/49 (4%)    0/50 (0%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     0/45.45      2/45.52      1/46.42      0/47.18     |1/41.88      2/44.20      0/43.99      1/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.2%         0.0%        |2.4%         4.5%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/41 (0%)    2/38 (5%)    1/42 (2%)    0/43 (0%)   |1/33 (3%)    1/35 (3%)    0/38 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |731 (T)      693          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.364N     P=0.222      P=0.505      (e)         |P=0.512N     P=0.529      P=0.472N     P=0.713N     | 
|POLY 3             |     P=0.373N     P=0.238      P=0.504      (e)         |P=0.562N     P=0.519      P=0.490N     P=0.740N     | 
|POLY 1.5           |     P=0.375N     P=0.237      P=0.504      (e)         |P=0.572N     P=0.513      P=0.493N     P=0.751N     | 
|POLY 6             |     P=0.369N     P=0.238      P=0.505      (e)         |P=0.550N     P=0.523      P=0.487N     P=0.728N     | 
|LOGISTIC REGRESSION|     (e)          P=0.222      P=0.505      (e)         |P=0.544N     P=0.519      (e)          P=0.713N     | 
|COCH-ARM / FISHERS |     P=0.378N     P=0.247      P=0.505      (e)         |P=0.585N     P=0.500      P=0.495N     P=0.747      | 
|ORDER RESTRICTED   |     P=0.318N     (e)          (e)          (e)         |P=0.365N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Incisor                                                                                                                   | 
|     Dysplasia                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/41 (100%) 43/43 (100%) 41/41 (100%) 35/35 (100%)|9/9 (100%)   13/13 (100%) 8/8 (100%)   15/15 (100%) | 
|POLY-3 RATE (b)    |     41/41.00     43/43.00     41/41.00     35/35.00    |9/9.00       13/13.00     8/8.00       15/15.00     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       100.0%      |100.0%       100.0%       100.0%       100.0%       | 
|TERMINAL (d)       |     35/35 (100%) 37/37 (100%) 38/38 (100%) 31/31 (100%)|8/8 (100%)   10/10 (100%) 8/8 (100%)   14/14 (100%) | 
|FIRST INCIDENCE    |     517          556          624          598         |681          550          731 (T)      725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/49 (0%)    1/50 (2%)    2/50 (4%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |                                                        |0/41.88      1/44.99      2/43.99      1/46.76      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         2.2%         4.6%         2.1%         | 
|TERMINAL (d)       |                                                        |0/33 (0%)    1/35 (3%)    2/38 (5%)    1/42 (2%)    | 
|FIRST INCIDENCE    |                                                        |---          731 (T)      731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.593      P=0.512      P=0.270      P=0.548      | 
|POLY 3             |                                                        |P=0.569      P=0.514      P=0.248      P=0.522      | 
|POLY 1.5           |                                                        |P=0.548      P=0.512      P=0.246      P=0.513      | 
|POLY 6             |                                                        |P=0.593      P=0.516      P=0.252      P=0.533      | 
|LOGISTIC REGRESSION|                                                        |(e)          P=0.512      P=0.270      P=0.548      | 
|COCH-ARM / FISHERS |                                                        |P=0.523      P=0.505      P=0.253      P=0.500      | 
|ORDER RESTRICTED   |                                                        |P=0.237      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/14/03                           EXPERIMENT: 88004 TEST: 06                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                      DIVINYLBENZENE    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      10 PPM       30 PPM       100 PPM     |CONTROL      10 PPM       30 PPM       100 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/49 (4%)    8/50 (16%)   5/50 (10%)   8/49 (16%)   | 
|POLY-3 RATE (b)    |                                                        |2/41.88      8/45.96      5/44.44      8/46.78      | 
|POLY-3 PERCENT (g) |                                                        |4.8%         17.4%        11.3%        17.1%        | 
|TERMINAL (d)       |                                                        |2/33 (6%)    5/35 (14%)   4/38 (11%)   7/42 (17%)   | 
|FIRST INCIDENCE    |                                                        |731 (T)      537          600          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.261      P=0.062      P=0.269      P=0.103      | 
|POLY 3             |                                                        |P=0.183      P=0.062      P=0.240      P=0.066      | 
|POLY 1.5           |                                                        |P=0.160      P=0.058      P=0.234      P=0.057      | 
|POLY 6             |                                                        |P=0.214      P=0.066      P=0.250      P=0.079      | 
|LOGISTIC REGRESSION|                                                        |P=0.167      P=0.056      P=0.236      P=0.103      | 
|COCH-ARM / FISHERS |                                                        |P=0.135      P=0.049 *    P=0.226      P=0.046 *    | 
|ORDER RESTRICTED   |                                                        |P=0.062      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.