TDMS Study 88004-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DIVINYLBENZENE DATE: 08/14/03
EXPERIMENT: 88004 TEST: 06 TIME: 13:10:08
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-75410 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 88004B
PATHOLOGIST: GRUMBEIN, SONDR CAS: 1321-74-0
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DIVINYLBENZENE DATE: 08/14/03
EXPERIMENT: 88004 TEST: 06 TIME: 13:10:08
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75410 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 88004B
PATHOLOGIST: GRUMBEIN, SONDR CAS: 1321-74-0
DIVINYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 456 517 536 565 573 609 620 662 676 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 338 543 556 600 629 639 641 672 697 702 |
| 711 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 479 526 570 572 586 624 672 696 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIVINYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 452 533 558 598 669 683 719 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIVINYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 90.0 84.0 82.0 |
| | |
| | |
|10 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 92.0 86.0 76.0 |
| | |
| | |
|30 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 88.0 84.0 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 92.0 92.0 86.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 10 PPM 30 PPM 100 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 82.0% 76.0% 84.0% 86.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.433N P=0.687 P=0.966N P=0.750N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 579.3 620.3 590.6 601.7 |
|NATURAL DEATHS (C) | (23.6) (30.6) (25.4) (35.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 702.1 702.9 706.9 711.2 |
|(STANDARD ERROR) | ( 9.2) ( 9.7) ( 8.2) ( 7.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIVINYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 352 366 386 450 479 576 586 596 625 658 |
| 660 676 681 687 709 710 711 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 506 515 537 550 564 586 613 638 656 693 |
| 707 709 715 719 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 1 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 334 501 512 536 550 564 577 600 709 711 |
| 719 |
| CENSORED DEATHS |
| 359 |
| |
==================================================================================
DIVINYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 200 383 407 697 697 704 725 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DIVINYLBENZENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 94.0 90.0 90.0 84.0 78.0 66.0 |
| | |
| | |
|10 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 88.0 82.0 70.0 |
| | |
| | |
|30 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 91.9 83.7 83.7 77.6 |
| | |
| | |
|100 PPM | 100.0 100.0 98.0 98.0 94.0 94.0 94.0 94.0 94.0 84.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 10 PPM 30 PPM 100 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 70.0% 77.6% 84.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.050N P=0.729N P=0.293N P=0.053N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 582.8 628.9 573.9 567.8 |
|NATURAL DEATHS (C) | (30.8) (20.8) (34.1) (72.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 680.6 700.4 689.0 704.9 |
|(STANDARD ERROR) | (14.4) ( 9.1) (13.5) (14.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DIVINYLBENZENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
10 PPM = 2
30 PPM = 3
100 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 41 3
|
| 2 41 3 1 342
|
P 96 + 1 312 2 3
E |
R | 1 21 2
C |
E 92 + 11 3 2 2 4
N |
T | 1 3 1 2 2 4 4
|
S 88 + 1 13 3 4 4
U |
R | 1 2 12 3 4 4
V |
I 84 + 121 2 3
V |
A | 1 22 1
L |
80 + 22
|
| 22
|
76 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.
DIVINYLBENZENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
10 PPM = 2
30 PPM = 3
100 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 1 2
|
| 4 3 1 1 4 322
| 1 41 4 3 2 2
95 +
| 1 4 1 3 2 2 4
P | 1 1 3 2 2
E |
R 90 + 1 3 2 12 44
C |
E | 3 11 2 4 4
N | 31 1 2 2 4 4
T 85 +
| 1 1 2 2 3 4
S | 1 1 2
U |
R 80 + 1 1 2 233
V |
I | 1 1 223 3
V | 11 22
A 75 +
L | 11
| 1 122
|
70 + 2 2
|
|
| 1 1
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.