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TDMS Study 93020-07 Pathology Tables

NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 1
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                                                                           TIME: 11:15:09

                                                         EIS REPORT 37


       FACILITY:  Southern Research Institute

       NTP C#:  93020D

       CONTRACT NUMBER:  N01-ES 05451

       CAS NUMBER:  693-13-0

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 2
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 2                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 3
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 4                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: FEMALE                               TRT: 10 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 4
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 6                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: FEMALE                               TRT: 20 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 5
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 8                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: FEMALE                               TRT: 40 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 6
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 1                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 7
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 3                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: MALE                                 TRT: 10 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 8
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 5                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: MALE                                 TRT: 20 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

143         143  617 12/31/01   645 01/28/02   2/22  Ulcer Site Of Application

  REMOVED  **  CID   143 **   REASON - MSAC
                                649 02/01/02         Ulcer/Abscess Appendage 2
                                649 02/01/02         Lethargic
                                649 02/01/02         Nasal/Eye Discharge
                                649 02/01/02         Ulcer Site Of Application

NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 9
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 7                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: MALE                                 TRT: 40 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.



                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------