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TDMS Study 93020-08 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Southern Research Inst                         DIISOPROPYLCARBODIIMIDE                                         DATE: 07/19/04  
EXPERIMENT: 93020 TEST: 08                                                                                        TIME: 09:04:30    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: SKIN APPLICATION                                       NTP:  C93020D     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: SOUTHERN RESEARCH INSTITUTE                      DIISOPROPYLCARBODIIMIDE                                     DATE: 07/19/04    
EXPERIMENT: 93020 TEST: 08                                                                                        TIME:  9:14:01    
SPECIES: MICE, B6C3F1                                                                                                               
TEST TYPE: TWO YEAR                                 ROUTE: DERMAL                                                 NTP:  93020D      
CONT: N01-ES-05451                                                                                                CAS: 693-13-0     
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                                     
                             TWO YEAR DERMAL STUDY OF DIISOPROPYLCARBODIIMIDE                                                       
==========================================================================================================                          
WEEK     0 MG/KG                10 MG/KG                 20 MG/KG                 40 MG/KG                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        22.4       50        22.4    100.0    50      22.4    100.0    50      22.4    100.0    50                               
  1        22.4       50        22.4    100.0    50      22.4    100.0    50      22.4    100.0    50                               
  2        23.6       50        23.4     99.2    50      23.6    100.0    50      23.7    100.4    50                               
  3        25.3       50        25.1     99.2    50      25.4    100.4    50      25.3    100.0    50                               
  4        26.0       50        25.9     99.6    50      26.1    100.4    50      26.2    100.8    50                               
  5        27.0       50        27.1    100.4    50      27.3    101.1    50      27.4    101.5    50                               
  6        28.4       50        28.2     99.3    50      28.5    100.4    49*     28.3     99.6    48*                              
  7        29.6       50        29.4     99.3    50      29.4     99.3    49      29.2     98.6    48                               
  8        30.3       50        29.8     98.3    50      30.0     99.0    49      29.9     98.7    48                               
  9        30.6       50        31.0    101.3    49      31.2    102.0    48      30.9    101.0    48                               
 10        32.0       50        31.5     98.4    49      31.5     98.4    48      31.4     98.1    48                               
 11        33.3       50        32.5     97.6    49      32.4     97.3    48      32.4     97.3    48                               
 12        33.8       50        33.3     98.5    49      33.6     99.4    48      33.5     99.1    48                               
 13        34.4       50        34.2     99.4    49      34.3     99.7    48      34.3     99.7    48                               
 17        37.2       50        37.0     99.5    49      37.5    100.8    48      37.1     99.7    48                               
 21        40.8       50        40.0     98.0    49      40.2     98.5    48      39.2     96.1    48                               
 25        42.7       50        41.8     97.9    49      42.0     98.4    48      41.2     96.5    48                               
 29        46.0       50        44.9     97.6    49      45.1     98.0    48      44.7     97.2    48                               
 33        47.8       50        46.8     97.9    49      46.4     97.1    48      45.8     95.8    48                               
 37        48.5       50        47.8     98.6    49      47.2     97.3    48      46.9     96.7    48                               
 41        49.2       50        47.4     96.3    49      48.4     98.4    48      47.5     96.5    48                               
 45        49.7       50        49.3     99.2    49      48.2     97.0    48      48.1     96.8    48                               
 49        50.2       50        49.9     99.4    49      49.3     98.2    48      49.5     98.6    48                               
 53        51.2       50        51.0     99.6    49      50.4     98.4    48      50.2     98.0    48                               
 57        51.2       50        51.2    100.0    49      50.8     99.2    48      50.7     99.0    48                               
 61        52.2       50        51.7     99.0    49      51.5     98.7    48      51.4     98.5    48                               
 65        51.7       50        52.1    100.8    48      51.6     99.8    48      51.4     99.4    48                               
 69        51.6       50        52.2    101.2    48      51.5     99.8    48      51.3     99.4    47                               
 73        51.1       50        51.8    101.4    48      51.4    100.6    46      51.2    100.2    45                               
 77        51.8       48        52.3    101.0    48      51.9    100.2    46      51.3     99.0    45                               
 81        52.6       48        53.4    101.5    47      53.0    100.8    46      53.2    101.1    44                               
 85        51.6       48        52.4    101.6    47      52.2    101.2    46      52.3    101.4    43                               
 89        51.3       46        52.0    101.4    46      53.0    103.3    45      52.1    101.6    43                               
 93        51.8       45        51.6     99.6    45      52.8    101.9    44      51.6     99.6    42                               
 97        50.3       44        51.2    101.8    43      52.5    104.4    42      51.8    103.0    39                               
101        49.8       43        50.9    102.2    41      52.1    104.6    40      51.3    103.0    38                               
TERM. SAC.            39                         40                       38                       36                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                                   
                             TWO YEAR DERMAL STUDY OF DIISOPROPYLCARBODIIMIDE                                                       
==========================================================================================================                          
WEEK     0 MG/KG                10 MG/KG                 20 MG/KG                 40 MG/KG                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        18.6       50        18.6    100.0    50      18.5     99.5    50      18.7    100.5    50                               
  1        18.6       50        18.6    100.0    50      18.5     99.5    50      18.7    100.5    50                               
  2        19.3       50        19.4    100.5    50      19.5    101.0    50      19.7    102.1    50                               
  3        21.2       50        21.1     99.5    49      21.0     99.1    49      21.2    100.0    50                               
  4        22.5       50        22.6    100.4    49      22.5    100.0    49      22.6    100.4    50                               
  5        23.3       50        23.0     98.7    49      23.2     99.6    49      23.5    100.9    50                               
  6        24.4       49*       24.5    100.4    49      24.2     99.2    49      24.8    101.6    50                               
  7        25.9       49        25.9    100.0    49      25.6     98.8    49      25.9    100.0    50                               
  8        26.3       49        26.4    100.4    49      26.4    100.4    49      26.5    100.8    50                               
  9        27.5       49        27.2     98.9    49      27.4     99.6    49      27.2     98.9    50                               
 10        27.8       49        27.3     98.2    49      27.5     98.9    49      27.5     98.9    50                               
 11        28.3       49        28.4    100.4    49      28.6    101.1    48      28.4    100.4    50                               
 12        29.3       49        29.4    100.3    49      29.4    100.3    48      29.1     99.3    50                               
 13        30.3       49        30.7    101.3    49      30.7    101.3    48      30.3    100.0    50                               
 17        33.3       49        34.6    103.9    49      35.0    105.1    48      33.9    101.8    49                               
 21        37.1       49        37.6    101.3    49      37.9    102.2    48      36.7     98.9    49                               
 25        40.4       49        40.4    100.0    49      40.9    101.2    48      40.1     99.3    49                               
 29        44.8       49        44.5     99.3    49      44.9    100.2    48      43.3     96.7    49                               
 33        46.4       49        46.6    100.4    49      46.6    100.4    48      44.9     96.8    49                               
 37        47.7       49        47.6     99.8    49      48.0    100.6    48      46.6     97.7    49                               
 41        49.9       49        49.4     99.0    49      49.7     99.6    48      48.3     96.8    49                               
 45        52.2       48        51.5     98.7    49      51.3     98.3    48      50.1     96.0    49                               
 49        54.9       48        53.9     98.2    49      53.7     97.8    48      52.3     95.3    49                               
 53        56.9       47        55.8     98.1    49      55.5     97.5    48      54.1     95.1    49                               
 57        59.6       47        58.2     97.7    49      57.8     97.0    48      57.1     95.8    49                               
 61        61.5       47        59.6     96.9    49      60.2     97.9    47      59.4     96.6    49                               
 65        62.9       47        60.1     95.5    49      60.2     95.7    47      59.9     95.2    49                               
 69        62.2       47        59.9     96.3    49      59.5     95.7    47      59.7     96.0    49                               
 73        62.0       45        60.2     97.1    49      59.6     96.1    47      59.5     96.0    48                               
 77        63.3       44        59.3     93.7    49      59.0     93.2    47      59.4     93.8    47                               
 81        65.7       44        63.0     95.9    47      61.4     93.5    46      62.1     94.5    46                               
 85        63.8       44        63.5     99.5    44      61.2     95.9    44      61.4     96.2    45                               
 89        63.2       41        63.3    100.2    42      61.8     97.8    42      62.4     98.7    42                               
 93        62.2       41        61.5     98.9    41      60.2     96.8    42      61.2     98.4    42                               
 97        61.0       39        60.9     99.8    38      58.9     96.6    41      60.3     98.9    41                               
101        59.2       35        61.8    104.4    34      57.9     97.8    39      58.6     99.0    41                               
TERM. SAC.            33                         33                       39                       40                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.