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TDMS Study 93020-08 Pathology Tables

NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04
Route: SKIN APPLICATION                                                                                           Time: 09:10:57

                                                         FINAL #1 MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  693-13-0

       Lock Date:  03/14/03

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            5            6            4                                     
    Moribund Sacrifice                                12           11            4            5                                     
    Accidently Killed                                               1            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           32           38           40                                     
    Natural Death                                                   1                                                               
    Moribund Sacrifice                                                           1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (47)         (42)         (47)                                   
      Cyst                                                          1 (2%)                                                          
   Intestine Large, Cecum                             (46)         (45)         (44)         (47)                                   
      Cyst                                             1 (2%)                                                                       
      Edema                                                                                   1 (2%)                                
   Intestine Small, Duodenum                          (46)         (46)         (44)         (47)                                   
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Perforation                                                                1 (2%)                                             
   Intestine Small, Jejunum                           (47)         (45)         (44)         (46)                                   
      Inflammation, Focal                                           1 (2%)                                                          
      Epithelium, Hyperplasia, Focal                                                          1 (2%)                                
      Peyer's Patch, Hyperplasia, Lymphoid                          1 (2%)                                                          
   Intestine Small, Ileum                             (46)         (44)         (45)         (47)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                               1 (2%)       2 (4%)                                                          
      Clear Cell Focus                                                                        1 (2%)                                
      Congestion                                       1 (2%)                                                                       
      Eosinophilic Focus                               6 (12%)      1 (2%)       6 (12%)                                            
      Hematopoietic Cell Proliferation                              2 (4%)                    1 (2%)                                
      Hyperplasia, Focal, Lymphoid                                  1 (2%)       2 (4%)                                             
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                    1 (2%)                                
      Infiltration Cellular, Mixed Cell               16 (32%)      9 (18%)     10 (20%)     22 (44%)                               
      Mineralization, Focal                                         1 (2%)                                                          
      Necrosis, Focal                                                            1 (2%)                                             
      Hepatocyte, Basophilic Focus                     1 (2%)                    1 (2%)       1 (2%)                                
      Hepatocyte, Clear Cell Focus                     3 (6%)       2 (4%)                    1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Eosinophilic Focus                                             4 (8%)                                             
      Hepatocyte, Karyomegaly                          1 (2%)                                                                       
      Hepatocyte, Mixed Cell Focus                     2 (4%)                    1 (2%)       6 (12%)                               
      Hepatocyte, Necrosis, Focal                      3 (6%)       3 (6%)       1 (2%)       1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic            5 (10%)      3 (6%)       1 (2%)       5 (10%)                               
   Mesentery                                          (23)         (20)         (14)         (18)                                   
      Hemorrhage                                                                 1 (7%)                                             
      Infiltration Cellular, Lymphoid                  1 (4%)                                                                       
      Infiltration Cellular, Mixed Cell                1 (4%)                                                                       
      Inflammation                                     3 (13%)      5 (25%)                   1 (6%)                                
      Artery, Inflammation                                                                    1 (6%)                                
      Fat, Necrosis, Focal                            17 (74%)     13 (65%)      9 (64%)     15 (83%)                               
   Pancreas                                           (50)         (48)         (50)         (50)                                   
      Inflammation, Focal                              1 (2%)                                                                       
      Acinus, Atrophy, Diffuse                                      2 (4%)                                                          
      Acinus, Atrophy, Focal                           1 (2%)       2 (4%)       1 (2%)       3 (6%)                                
      Duct, Cyst, Focal, Multiple                                   2 (4%)                    1 (2%)                                
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Diverticulum                                                               1 (2%)       1 (2%)                                
      Erosion                                          2 (4%)                    2 (4%)                                             
      Inflammation, Focal                              1 (2%)                    1 (2%)       1 (2%)                                
      Ulcer                                            1 (2%)       1 (2%)                    2 (4%)                                
      Epithelium, Hyperplasia                          4 (8%)       4 (8%)       2 (4%)       1 (2%)                                
   Stomach, Glandular                                 (49)         (48)         (47)         (50)                                   
      Erosion                                                                                 1 (2%)                                
      Glands, Hyperplasia, Focal                                    1 (2%)                                                          
   Tooth                                              (1)          (1)          (1)          (2)                                    
      Malformation                                                  1 (100%)                  1 (50%)                               
      Peridontal Tissue, Inflammation, Chronic                                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)         (50)                                   
      Cardiomyopathy                                                3 (6%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
      Infiltration Cellular, Mixed Cell                1 (2%)                                                                       
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Thrombosis                                       4 (8%)                    2 (4%)                                             
      Artery, Inflammation, Chronic                    1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Accessory Adrenal Cortical Nodule                2 (4%)       1 (2%)       1 (2%)       3 (6%)                                
      Angiectasis                                                   1 (2%)                                                          
      Cytoplasmic Alteration, Focal                    1 (2%)       2 (4%)       1 (2%)                                             
      Degeneration, Cystic                             1 (2%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Necrosis, Focal                                                                         1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (49)         (49)                                   
      Angiectasis                                                   1 (2%)                                                          
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Suppurative                                     1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (49)         (50)         (50)                                   
      Hyperplasia                                                   2 (4%)       1 (2%)                                             
   Parathyroid Gland                                  (46)         (43)         (49)         (49)                                   
      Cyst                                             2 (4%)       2 (5%)                    1 (2%)                                
   Pituitary Gland                                    (48)         (50)         (50)         (46)                                   
      Angiectasis                                      3 (6%)       1 (2%)       1 (2%)       3 (7%)                                
      Cyst                                                                       1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Pars Distalis, Cytoplasmic Alteration, Focal     2 (4%)                    4 (8%)       1 (2%)                                
      Pars Distalis, Degeneration, Cystic, Focal       1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                3 (6%)       2 (4%)       7 (14%)      3 (7%)                                
      Pars Intermedia, Hyperplasia, Focal                                        1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                                          2 (4%)       3 (6%)       1 (2%)                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      C-Cell, Hyperplasia                                           2 (4%)                                                          
      Follicle, Degeneration, Cystic, Focal           14 (28%)     14 (28%)     18 (36%)     12 (24%)                               
      Follicular Cell, Hyperplasia, Focal              1 (2%)      11 (22%)      9 (18%)      4 (8%)                                
      Follicular Cell, Vacuolization Cytoplasmic,                                                                                   
         Focal                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (5)          (8)          (3)          (4)                                    
      Mediastinum, Infiltration Cellular, Lymphoid     1 (20%)                                1 (25%)                               
      Mediastinum, Inflammation, Suppurative                        1 (13%)                   1 (25%)                               
      Nasal, Hemorrhage                                             1 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (48)         (48)         (47)                                   
      Degeneration, Cystic                                                       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
   Ovary                                              (49)         (50)         (49)         (49)                                   
      Angiectasis                                      2 (4%)       3 (6%)       1 (2%)       1 (2%)                                
      Cyst                                            14 (29%)     16 (32%)     13 (27%)     18 (37%)                               
      Hemorrhage                                       2 (4%)                                                                       
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation, Suppurative                        2 (4%)       2 (4%)                    2 (4%)                                
      Thrombosis                                       2 (4%)       1 (2%)       1 (2%)                                             
      Bilateral, Cyst                                                            1 (2%)                                             
      Bilateral, Inflammation, Suppurative             1 (2%)                                 1 (2%)                                
      Interstitial Cell, Hyperplasia                                1 (2%)                                                          
   Oviduct                                            (3)          (1)                                                              
      Inflammation, Suppurative                        3 (100%)                                                                     
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                        5 (10%)      8 (16%)      6 (12%)      2 (4%)                                
      Thrombosis                                                                              1 (2%)                                
      Cervix, Hypertrophy                                           1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic                46 (92%)     44 (88%)     47 (94%)     49 (98%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (49)                                   
      Hyperplasia                                     14 (29%)      5 (10%)     10 (20%)      2 (4%)                                
   Lymph Node                                         (11)         (13)         (10)         (10)                                   
      Hyperplasia, Lymphoid                                                      1 (10%)                                            
      Bronchial, Hyperplasia, Lymphoid                                           1 (10%)                                            
      Iliac, Ectasia                                                1 (8%)       1 (10%)      3 (30%)                               
      Iliac, Hemorrhage                                2 (18%)                                                                      
      Iliac, Hyperplasia, Lymphoid                     2 (18%)      2 (15%)      2 (20%)      2 (20%)                               
      Inguinal, Hyperplasia, Lymphoid                  1 (9%)                                                                       
      Mediastinal, Ectasia                             1 (9%)                                                                       
      Mediastinal, Hemorrhage                                       1 (8%)                                                          
      Mediastinal, Hyperplasia                                      1 (8%)                                                          
      Mediastinal, Hyperplasia, Lymphoid               1 (9%)       2 (15%)      1 (10%)      3 (30%)                               
      Pancreatic, Hemorrhage                                        1 (8%)                                                          
      Pancreatic, Hyperplasia, Lymphoid                1 (9%)       1 (8%)                    1 (10%)                               
      Renal, Ectasia                                                1 (8%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Renal, Hyperplasia, Lymphoid                     1 (9%)       1 (8%)       2 (20%)                                            
   Lymph Node, Mandibular                             (47)         (49)         (49)         (48)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            6 (13%)      4 (8%)       2 (4%)       1 (2%)                                
   Lymph Node, Mesenteric                             (47)         (48)         (49)         (50)                                   
      Ectasia                                          1 (2%)       1 (2%)       5 (10%)      2 (4%)                                
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Lymphoid                            3 (6%)       6 (13%)      2 (4%)       5 (10%)                               
   Spleen                                             (49)         (49)         (50)         (50)                                   
      Accessory Spleen                                                           1 (2%)                                             
      Atrophy                                                                    1 (2%)                                             
      Congestion                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                24 (49%)     21 (43%)     18 (36%)     13 (26%)                               
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            6 (12%)     12 (24%)     12 (24%)      6 (12%)                               
      Capsule, Inflammation, Chronic, Focal            1 (2%)                                                                       
   Thymus                                             (46)         (48)         (44)         (47)                                   
      Hyperplasia, Lymphoid                            5 (11%)      4 (8%)       4 (9%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (49)                                   
      Dilatation                                       1 (2%)                                                                       
      Hyperplasia                                                                             1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 (2%)                                                                       
      Control Dermis, Hyperplasia, Focal                                                      1 (2%)                                
      Control Dermis, Inflammation, Focal              1 (2%)                    1 (2%)       1 (2%)                                
      Control Epidermis, Hyperplasia, Focal            1 (2%)                                 1 (2%)                                
      Epidermis, Hyperplasia, Focal                    1 (2%)                                                                       
      Site of Application - Dermis, Fibrosis                                                  1 (2%)                                
      Site of Application - Dermis, Inflammation,                                                                                   
         Focal                                         3 (6%)       2 (4%)       7 (14%)      2 (4%)                                
      Site of Application - Epidermis, Hyperplasia     5 (10%)      3 (6%)       7 (14%)      7 (14%)                               
      Site of Application, Ulcer                       2 (4%)       1 (2%)                                                          
      Subcutaneous Tissue, Angiectasis, Focal                       1 (2%)                                                          
      Subcutaneous Tissue, Edema                       1 (2%)       2 (4%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                     3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression, Focal                               2 (4%)       2 (4%)                    1 (2%)                                
      Hemorrhage, Focal                                1 (2%)       2 (4%)                                                          
      Infarct                                          1 (2%)                                                                       
      Inflammation, Focal                                           1 (2%)                                                          
      Cerebellum, Hippocampus, Necrosis                1 (2%)                                                                       
      Cerebrum, Atrophy, Focal                                      1 (2%)                                                          
      Hippocampus, Necrosis, Acute                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       2 (4%)                    1 (2%)       1 (2%)                                
      Foreign Body                                                                            1 (2%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Histiocytic                                      1 (2%)                    1 (2%)                                
      Infiltration Cellular, Polymorphonuclear                      2 (4%)                                                          
      Mineralization, Focal                            1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Mediastinum, Hyperplasia, Lymphoid                            2 (4%)                                                          
   Nose                                               (50)         (50)         (49)         (50)                                   
      Inflammation                                                               1 (2%)                                             
      Nasolacrimal Duct, Inflammation                  1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (47)         (48)         (49)         (49)                                   
      Atrophy                                          1 (2%)                    2 (4%)                                             
      Phthisis Bulbi                                                             1 (2%)                                             
      Cornea, Hyperplasia, Squamous                                 1 (2%)       1 (2%)                                             
      Cornea, Inflammation, Chronic                                 1 (2%)                                                          
      Iris, Synechia                                                1 (2%)                                                          
      Lens, Cataract                                                1 (2%)                                                          
   Harderian Gland                                    (50)         (49)         (50)         (50)                                   
      Cyst                                                                                    1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Inflammation                                                  2 (4%)                                                          
      Epithelium, Hyperplasia, Focal                   1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)         (49)                                   
      Congestion                                       1 (2%)                                                                       
      Cyst                                             1 (2%)                    4 (8%)                                             
      Hydronephrosis                                                             1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Infarct                                          3 (6%)       2 (4%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
      Inflammation                                     1 (2%)       1 (2%)                                                          
      Metaplasia, Focal, Osseous                       5 (10%)      2 (4%)                    1 (2%)                                
      Nephropathy                                     13 (27%)      8 (16%)     11 (22%)     18 (37%)                               
      Capsule, Congestion                              1 (2%)                                                                       
      Papilla, Necrosis                                1 (2%)                                                                       
      Renal Tubule, Accumulation, Hyaline Droplet      3 (6%)       1 (2%)                    2 (4%)                                
      Renal Tubule, Necrosis                           1 (2%)                                                                       
      Renal Tubule, Vacuolization Cytoplasmic,                                                                                      
         Focal                                         1 (2%)       1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            1            2            5                                     
    Natural Death                                      6            9           10            8                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           40           38           36                                     
    Moribund Sacrifice                                 1                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (42)         (43)         (41)                                   
      Cyst                                             1 (2%)       1 (2%)       2 (5%)                                             
      Epithelium, Degeneration, Hyaline                             1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Intestine Small, Duodenum                          (46)         (44)         (44)         (40)                                   
      Ectopic Tissue                                                1 (2%)                                                          
      Serosa, Inflammation, Chronic                                                           1 (3%)                                
   Intestine Small, Jejunum                           (46)         (43)         (44)         (40)                                   
      Cyst                                                                                    1 (3%)                                
      Inflammation, Focal                                           1 (2%)       1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)       1 (2%)                    1 (3%)                                
   Intestine Small, Ileum                             (46)         (44)         (44)         (40)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (49)                                   
      Atrophy                                          1 (2%)                                                                       
      Basophilic Focus                                 1 (2%)                                                                       
      Clear Cell Focus                                 2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Eosinophilic Focus                               2 (4%)       1 (2%)       1 (2%)       4 (8%)                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hemorrhage, Focal                                                                       1 (2%)                                
      Hepatodiaphragmatic Nodule                                                              1 (2%)                                
      Hyperplasia, Focal, Histiocytic                               1 (2%)                                                          
      Infarct                                                                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Polymorphonuclear         1 (2%)                                                                       
      Infiltration Cellular, Mixed Cell                8 (16%)      5 (10%)      5 (10%)      6 (12%)                               
      Inflammation, Focal, Granulomatous                                                      1 (2%)                                
      Pigmentation, Focal                                           1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Thrombosis                                                                 1 (2%)                                             
      Bile Duct, Hyperplasia                           1 (2%)                    1 (2%)                                             
      Capsule, Inflammation, Chronic                                                          1 (2%)                                
      Hepatocyte, Clear Cell Focus                    19 (38%)     17 (34%)     12 (24%)      8 (16%)                               
      Hepatocyte, Eosinophilic Focus                   2 (4%)                                                                       
      Hepatocyte, Mixed Cell Focus                     1 (2%)       2 (4%)                    2 (4%)                                
      Hepatocyte, Necrosis, Focal                      5 (10%)      3 (6%)       2 (4%)       7 (14%)                               
      Hepatocyte, Vacuolization Cytoplasmic           18 (36%)     17 (34%)     17 (34%)     18 (37%)                               
   Mesentery                                          (49)         (49)         (50)         (50)                                   
      Fibrosis, Focal                                                            1 (2%)                                             
      Inflammation                                                  1 (2%)                    1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Artery, Inflammation                                          1 (2%)                                                          
      Fat, Necrosis, Focal                             4 (8%)       2 (4%)       4 (8%)       4 (8%)                                
   Pancreas                                           (49)         (50)         (49)         (49)                                   
      Inflammation, Focal                                                        1 (2%)                                             
      Necrosis, Focal                                               1 (2%)       1 (2%)                                             
      Acinus, Atrophy, Focal                                                                  3 (6%)                                
      Serosa, Inflammation, Chronic                                                           1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                    1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Diverticulum                                                                            1 (2%)                                
      Erosion                                                       1 (2%)                                                          
      Inflammation, Focal                                                        1 (2%)       1 (2%)                                
      Ulcer                                                         1 (2%)                                                          
      Epithelium, Cyst                                                                        1 (2%)                                
      Epithelium, Hyperplasia                          2 (4%)       2 (4%)       3 (6%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (47)         (48)         (47)                                   
      Erosion                                          4 (8%)       1 (2%)       1 (2%)                                             
   Tooth                                              (18)         (11)         (15)         (12)                                   
      Malformation                                    18 (100%)    11 (100%)    15 (100%)    12 (100%)                              
      Peridontal Tissue, Inflammation, Chronic                                   1 (7%)                                             
      Pulp, Inflammation                                                         1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                                             1 (2%)       1 (2%)                                
      Infiltration Cellular, Mixed Cell                                                       1 (2%)                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Accessory Adrenal Cortical Nodule                3 (6%)       2 (4%)       2 (4%)       2 (4%)                                
      Cytoplasmic Alteration, Focal                    9 (18%)      5 (10%)      7 (14%)      4 (8%)                                
      Degeneration, Cystic                                                                    1 (2%)                                
      Hyperplasia, Focal, Histiocytic                               1 (2%)                                                          
      Hypertrophy                                                                1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
   Adrenal Medulla                                    (49)         (50)         (50)         (49)                                   
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia, Focal                                                         1 (2%)                                             
   Islets, Pancreatic                                 (49)         (50)         (49)         (50)                                   
      Hyperplasia                                      2 (4%)       2 (4%)       2 (4%)       1 (2%)                                
   Parathyroid Gland                                  (49)         (50)         (46)         (47)                                   
      Cyst                                             1 (2%)                    2 (4%)       1 (2%)                                
   Pituitary Gland                                    (48)         (47)         (50)         (49)                                   
      Cyst                                             1 (2%)       2 (4%)       3 (6%)       3 (6%)                                
      Pars Distalis, Cytoplasmic Alteration, Focal     1 (2%)                    5 (10%)                                            
      Pars Distalis, Hyperplasia, Focal                1 (2%)                                                                       
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      C-Cell, Hyperplasia                              1 (2%)       3 (6%)                                                          
      Follicle, Degeneration, Cystic, Focal            4 (8%)       6 (12%)      8 (16%)      6 (12%)                               
      Follicular Cell, Hyperplasia, Focal              7 (14%)      7 (14%)      8 (16%)      3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (3)          (2)                                    
      Hemorrhage                                                                              1 (50%)                               
      Abdominal, Cyst                                                            1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                                            1 (2%)       1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
      Spermatocele                                                  1 (2%)                                                          
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                                                                    2 (4%)                                
      Degeneration, Cystic                             3 (6%)       1 (2%)       1 (2%)       4 (8%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation, Chronic                           11 (22%)      8 (16%)     10 (20%)      6 (12%)                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation                                                  1 (2%)                    2 (4%)                                
      Epithelium, Hyperplasia, Focal                   2 (4%)       1 (2%)                                                          
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Cyst                                                          1 (2%)                                                          
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)       1 (2%)                                             
      Interstitial Cell, Hyperplasia, Focal                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
      Hyperplasia                                      9 (18%)     13 (26%)     12 (24%)      7 (14%)                               
      Thrombosis                                                                              1 (2%)                                
   Lymph Node                                         (6)          (5)          (5)          (4)                                    
      Bronchial, Hyperplasia, Lymphoid                              1 (20%)                                                         
      Iliac, Hyperplasia, Lymphoid                                                            1 (25%)                               
      Inguinal, Hyperplasia, Lymphoid                  2 (33%)      3 (60%)      4 (80%)      1 (25%)                               
      Mediastinal, Hyperplasia, Lymphoid                                         1 (20%)                                            
      Pancreatic, Hyperplasia, Lymphoid                             1 (20%)      1 (20%)      1 (25%)                               
   Lymph Node, Mandibular                             (47)         (48)         (47)         (47)                                   
      Hyperplasia, Histiocytic                                                                1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (48)         (49)         (48)                                   
      Ectasia                                                                    1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                       3 (6%)       1 (2%)       3 (6%)                                             
      Hyperplasia, Lymphoid                            3 (6%)       2 (4%)       4 (8%)       2 (4%)                                
   Spleen                                             (49)         (50)         (50)         (47)                                   
      Atrophy                                          1 (2%)                    1 (2%)                                             
      Fibrosis, Focal                                                                         1 (2%)                                
      Hematopoietic Cell Proliferation                15 (31%)     13 (26%)     14 (28%)     13 (28%)                               
      Hyperplasia, Lymphoid                            2 (4%)       5 (10%)      1 (2%)       1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
      Capsule, Inflammation, Chronic                                                          1 (2%)                                
   Thymus                                             (47)         (44)         (47)         (46)                                   
      Cyst                                             2 (4%)       1 (2%)       2 (4%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Ulcer                                            1 (2%)                                                                       
      Epidermis, Hyperplasia, Focal                    1 (2%)                    1 (2%)                                             
      Site of Application - Dermis, Inflammation,                                                                                   
         Focal                                         2 (4%)       2 (4%)       9 (18%)      1 (2%)                                
      Site of Application - Epidermis, Hyperplasia     2 (4%)       3 (6%)      10 (20%)      1 (2%)                                
      Site of Application, Ulcer                                    1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Angiectasis, Focal                                    1 (2%)                                             
      Subcutaneous Tissue, Edema                                                              2 (4%)                                
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
         Focal                                                                   1 (2%)                                             
      Subcutaneous Tissue, Thrombosis                                            1 (2%)                                             
      Subcutaneous Tissue, Site of Application,                                                                                     
         Infiltration Cellular                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                     2 (4%)       2 (4%)       1 (2%)                                             
   Skeletal Muscle                                    (2)          (2)          (2)          (5)                                    
      Inflammation, Chronic                                                                   1 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Histiocytic                         1 (2%)       1 (2%)       4 (8%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          4 (8%)       2 (4%)       1 (2%)       3 (6%)                                
      Mediastinum, Hyperplasia, Lymphoid               1 (2%)                                                                       
   Nose                                               (49)         (50)         (50)         (50)                                   
      Inflammation                                     2 (4%)                    1 (2%)                                             
      Nasolacrimal Duct, Cyst                                       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 93020-08         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:10:57    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Nasolacrimal Duct, Hyperplasia, Focal            1 (2%)       2 (4%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation                  1 (2%)                    2 (4%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (46)         (46)         (47)         (44)                                   
      Atrophy                                          1 (2%)                                                                       
      Inflammation                                     1 (2%)                                                                       
      Cornea, Hyperplasia, Squamous                                 1 (2%)                    1 (2%)                                
      Cornea, Inflammation, Chronic                    2 (4%)       3 (7%)       1 (2%)       3 (7%)                                
      Cornea, Necrosis, Focal                                       1 (2%)                    1 (2%)                                
      Retrobulbar, Inflammation                                                               1 (2%)                                
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Degeneration, Cystic, Focal                                   1 (2%)                                                          
      Inflammation                                     1 (2%)                                 1 (2%)                                
      Epithelium, Hyperplasia, Focal                   3 (6%)                    3 (6%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (48)         (50)         (48)                                   
      Cyst                                             3 (6%)      10 (21%)      5 (10%)      3 (6%)                                
      Hydronephrosis                                   2 (4%)       1 (2%)                                                          
      Infarct                                          2 (4%)       3 (6%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Mixed Cell                                          1 (2%)                                             
      Inflammation                                                                            3 (6%)                                
      Metaplasia, Focal, Osseous                       4 (8%)       2 (4%)       1 (2%)                                             
      Nephropathy                                     46 (96%)     44 (92%)     41 (82%)     40 (83%)                               
      Pelvis, Dilatation                                                                      1 (2%)                                
      Renal Tubule, Hyperplasia, Focal                 2 (4%)       3 (6%)                    1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Inflammation                                                  1 (2%)                    2 (4%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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