National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19236

TDMS Study 93020-08 Pathology Tables

NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04
Route: SKIN APPLICATION                                                                                           Time: 09:11:56

                                                         FINAL #1 MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  693-13-0

       Lock Date:  03/14/03

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      5            5            6            4                                     
    Moribund Sacrifice                                12           11            4            5                                     
    Accidently Killed                                               1            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           32           38           40                                     
    Natural Death                                                   1                                                               
    Moribund Sacrifice                                                           1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)         (50)                                   
   Gallbladder                                        (42)         (47)         (42)         (47)                                   
   Intestine Large, Colon                             (49)         (48)         (48)         (48)                                   
   Intestine Large, Cecum                             (46)         (45)         (44)         (47)                                   
   Intestine Small, Duodenum                          (46)         (46)         (44)         (47)                                   
      Adenoma                                          1 (2%)                                                                       
   Intestine Small, Jejunum                           (47)         (45)         (44)         (46)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                                  1 (2%)       1 (2%)                                
   Intestine Small, Ileum                             (46)         (44)         (45)         (47)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)                    1 (2%)                                
      Hepatocellular Carcinoma                         8 (16%)      2 (4%)       7 (14%)      3 (6%)                                
      Hepatocellular Carcinoma, Multiple               2 (4%)                    1 (2%)                                             
      Hepatocellular Adenoma                          13 (26%)     16 (32%)     10 (20%)      9 (18%)                               
      Hepatocellular Adenoma, Multiple                 8 (16%)     11 (22%)     11 (22%)      9 (18%)                               
      Hepatocholangiocarcinoma, Multiple                                                      1 (2%)                                
      Histiocytic Sarcoma                              3 (6%)                    2 (4%)       1 (2%)                                
      Liposarcoma, Metastatic, Tissue NOS                           1 (2%)                                                          
   Mesentery                                          (23)         (20)         (14)         (18)                                   
      Hemangiosarcoma, Metastatic, Liver                                                      1 (6%)                                
      Histiocytic Sarcoma                              1 (4%)                    2 (14%)      2 (11%)                               
      Liposarcoma                                                                             1 (6%)                                
   Pancreas                                           (50)         (48)         (50)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (49)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
   Stomach, Glandular                                 (49)         (48)         (47)         (50)                                   
   Tooth                                              (1)          (1)          (1)          (2)                                    
      Peridontal Tissue, Histiocytic Sarcoma,                                                                                       
          Metastatic, Uncertain Primary Site           1 (100%)                                                                     
      Peridontal Tissue, Histiocytic Sarcoma,                                                                                       
          Metastatic, Nose                                                                    1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)         (50)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Subcapsular, Adenoma                                                                    1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (49)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Pheochromocytoma Benign                                       1 (2%)                    1 (2%)                                
   Islets, Pancreatic                                 (50)         (49)         (50)         (50)                                   
      Adenoma                                                       2 (4%)                                                          
   Pituitary Gland                                    (48)         (50)         (50)         (46)                                   
      Pars Distalis, Adenoma                           4 (8%)      12 (24%)      3 (6%)      10 (22%)                               
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                                      2 (4%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, Follicular Cell, Adenoma              1 (2%)                                                                       
      Follicular Cell, Adenoma                         2 (4%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (5)          (8)          (3)          (4)                                    
      Abdominal, Pelvic, Liposarcoma                                1 (13%)                                                         
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                                                   1 (25%)                               
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENERAL BODY SYSTEM - cont                                                                                                          
      Mediastinum, Histiocytic Sarcoma                 1 (20%)                   1 (33%)                                            
      Thoracic, Hepatocholangiocarcinoma,                                                                                           
          Metastatic, Liver                                                                   1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (50)         (49)         (49)                                   
      Cystadenoma                                      1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       1 (2%)                                
      Teratoma Benign                                                            1 (2%)                                             
   Oviduct                                            (3)          (1)                                                              
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                              3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
      Leiomyosarcoma                                                                          2 (4%)                                
      Endometrium, Carcinoma                                        1 (2%)                                                          
      Endometrium, Polyp Stromal                       4 (8%)       2 (4%)       5 (10%)                                            
      Endometrium, Sarcoma Stromal                                               1 (2%)                                             
   Vagina                                                                                    (1)                                    
      Histiocytic Sarcoma                                                                     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                                        2 (4%)       1 (2%)                                
      Liposarcoma, Metastatic, Tissue NOS                           1 (2%)                                                          
   Lymph Node                                         (11)         (13)         (10)         (10)                                   
      Bronchial, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                                      1 (10%)                                            
      Iliac, Carcinoma, Metastatic, Uterus                          1 (8%)                                                          
      Iliac, Histiocytic Sarcoma                                                 1 (10%)                                            
      Mediastinal, Histiocytic Sarcoma                 1 (9%)                    1 (10%)      1 (10%)                               
      Pancreatic, Histiocytic Sarcoma                                            1 (10%)                                            
      Pancreatic, Squamous Cell Carcinoma,                                                                                          
          Metastatic, Stomach, Forestomach                                       1 (10%)                                            
      Renal, Histiocytic Sarcoma                                                 1 (10%)                                            
   Lymph Node, Mandibular                             (47)         (49)         (49)         (48)                                   
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       1 (2%)                                
   Lymph Node, Mesenteric                             (47)         (48)         (49)         (50)                                   
      Hemangioma                                                    1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)       1 (2%)                                
   Spleen                                             (49)         (49)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                    2 (4%)       2 (4%)                                
   Thymus                                             (46)         (48)         (44)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (49)                                   
      Carcinoma                                        1 (2%)                    2 (4%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basosquamous Tumor Benign                                                  1 (2%)                                             
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Site of Application, Basal Cell Adenoma                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Hemangioma                  2 (4%)       1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma             2 (4%)       1 (2%)                                                          
      Subcutaneous Tissue, Melanoma Malignant                       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Squamous Cell Carcinoma                                            1 (2%)                                
      Subcutaneous Tissue, Site of Application,                                                                                     
           Melanoma Benign                                                                    1 (2%)                                
      Subcutaneous Tissue, Site of Application,                                                                                     
           Myxoma                                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                  1 (2%)                                                          
      Cranium, Osteosarcoma                                                                   1 (2%)                                
   Skeletal Muscle                                                 (4)          (1)          (1)                                    
      Lipoma                                                        1 (25%)                                                         
      Rhabdomyosarcoma                                                           1 (100%)                                           
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                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Spinal Cord                                        (1)          (3)                       (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)       2 (4%)       2 (4%)       1 (2%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (2%)       1 (2%)       4 (8%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                    1 (2%)                                             
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    4 (8%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                                        2 (4%)       1 (2%)                                
      Liposarcoma, Metastatic, Tissue NOS                           1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
      Sarcoma Stromal, Metastatic, Uterus                                        1 (2%)                                             
   Nose                                               (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (47)         (48)         (49)         (49)                                   
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Retrobulbar, Carcinoma, Metastatic,                                                                                           
          Harderian Gland                              1 (2%)                                                                       
      Retrobulbar, Sarcoma                                                       1 (2%)                                             
   Harderian Gland                                    (50)         (49)         (50)         (50)                                   
      Adenoma                                          9 (18%)      5 (10%)      5 (10%)      3 (6%)                                
      Carcinoma                                        1 (2%)                    4 (8%)       1 (2%)                                
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)                    2 (4%)       1 (2%)                                
   Ureter                                                          (1)                       (1)                                    
      Histiocytic Sarcoma                                                                     1 (100%)                              
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
      Lymphoma Malignant                              10 (20%)      9 (18%)      7 (14%)      7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          43          41          41                                       
     Total Primary Neoplasms                           85          84          76          70                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 35          38          28          31                                       
     Total Benign Neoplasms                            52          62          44          44                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          19          26          18                                       
     Total Malignant Neoplasms                         33          22          32          26                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3           9           4                                       
     Total Metastatic Neoplasm                          4           5          11           7                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            1            2            5                                     
    Natural Death                                      6            9           10            8                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           40           38           36                                     
    Moribund Sacrifice                                 1                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (46)         (43)         (44)         (42)                                   
      Leiomyoma                                                                               1 (2%)                                
   Intestine Small, Duodenum                          (46)         (44)         (44)         (40)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (43)         (44)         (40)                                   
      Carcinoma                                                                  1 (2%)       1 (3%)                                
   Intestine Small, Ileum                             (46)         (44)         (44)         (40)                                   
      Carcinoma                                                                  1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (49)                                   
      Cholangiocarcinoma                               1 (2%)                                                                       
      Hemangiosarcoma                                               2 (4%)       1 (2%)       1 (2%)                                
      Hepatoblastoma                                                1 (2%)                                                          
      Hepatocellular Carcinoma                        16 (32%)      8 (16%)      8 (16%)      8 (16%)                               
      Hepatocellular Carcinoma, Multiple               4 (8%)       7 (14%)      3 (6%)       3 (6%)                                
      Hepatocellular Adenoma                           9 (18%)     15 (30%)     11 (22%)     10 (20%)                               
      Hepatocellular Adenoma, Multiple                 9 (18%)      7 (14%)      8 (16%)      9 (18%)                               
      Hepatocholangiocarcinoma                                                   1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Stomach,                                                                                 
           Forestomach                                                                        1 (2%)                                
   Mesentery                                          (49)         (49)         (50)         (50)                                   
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma                                                                                 1 (2%)                                
      Schwannoma Malignant, Metastatic, Uncertain                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
          Primary Site                                                                        1 (2%)                                
   Pancreas                                           (49)         (50)         (49)         (49)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Duct, Carcinoma                                                                         1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Serosa, Carcinoma, Metastatic, Pancreas                                                 1 (2%)                                
   Stomach, Glandular                                 (50)         (47)         (48)         (47)                                   
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Adenoma                                          1 (2%)       1 (2%)                    1 (2%)                                
      Bilateral, Subcapsular, Adenoma                  1 (2%)                                                                       
      Subcapsular, Adenoma                             3 (6%)       2 (4%)       6 (12%)      4 (8%)                                
   Adrenal Medulla                                    (49)         (50)         (50)         (49)                                   
      Pheochromocytoma Malignant                                                              1 (2%)                                
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (50)         (49)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)                    1 (2%)                                
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (48)         (47)         (50)         (49)                                   
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                                      1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (49)         (49)         (49)         (50)                                   
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Sarcoma                                                                                 1 (2%)                                
   Tissue NOS                                                                   (3)          (2)                                    
      Abdominal, Hepatocellular Carcinoma,                                                                                          
          Metastatic, Liver                                                      1 (33%)                                            
      Mediastinum, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                      1 (33%)      1 (50%)                               
      Thoracic, Hepatocellular Carcinoma,                                                                                           
          Metastatic, Liver                                                      1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                                                 1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                            1 (2%)       2 (4%)                                
   Lymph Node                                         (6)          (5)          (5)          (4)                                    
      Mediastinal, Carcinoma, Metastatic, Pancreas                                            1 (25%)                               
      Mediastinal, Hepatoblastoma, Metastatic,                                                                                      
           Liver                                       1 (17%)                                                                      
      Mediastinal, Sarcoma, Metastatic, Uncertain                                                                                   
          Primary Site                                                                        1 (25%)                               
   Lymph Node, Mandibular                             (47)         (48)         (47)         (47)                                   
   Lymph Node, Mesenteric                             (50)         (48)         (49)         (48)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Spleen                                             (49)         (50)         (50)         (47)                                   
      Hemangiosarcoma                                                            1 (2%)       2 (4%)                                
   Thymus                                             (47)         (44)         (47)         (46)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (1)                                    (1)                                    
      Carcinoma                                        1 (100%)                                                                     
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                                    1 (2%)                                
      Subcutaneous Tissue, Hepatoblastoma,                                                                                          
          Metastatic, Liver                            1 (2%)                                                                       
      Subcutaneous Tissue, Site of Application,                                                                                     
           Lymphoma Malignant                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (2)          (2)          (5)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (20%)                               
      Carcinoma, Metastatic, Pancreas                                                         1 (20%)                               
      Hemangiosarcoma                                                            1 (50%)                                            
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (50%)                                                         
      Rhabdomyosarcoma                                 1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                   (1)                       (1)          (3)                                    
      Schwannoma Malignant                                                                    1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     6 (12%)      5 (10%)      7 (14%)      7 (14%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       3 (6%)       2 (4%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                   2 (4%)                                             
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
      Carcinoma, Metastatic, Pancreas                                                         1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      7 (14%)      6 (12%)      4 (8%)       3 (6%)                                
      Hepatocellular Carcinoma, Metastatic, Lung       1 (2%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Mediastinum, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                         1 (2%)       1 (2%)                                             
   Nose                                               (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (46)         (46)         (47)         (44)                                   
      Retrobulbar, Carcinoma, Metastatic,                                                                                           
          Harderian Gland                              1 (2%)                                                                       
      Retrobulbar, Sarcoma                             1 (2%)                                                                       
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                          6 (12%)      9 (18%)     10 (20%)      8 (16%)                               
      Carcinoma                                        2 (4%)       1 (2%)                    3 (6%)                                
      Bilateral, Adenoma                               3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (48)         (50)         (48)                                   
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Uncertain                                                                                   
          Primary Site                                                                        1 (2%)                                
      Capsule, Carcinoma, Metastatic, Pancreas                                                1 (2%)                                
      Renal Tubule, Adenoma                                         1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Hemangioma                                       1 (2%)                    1 (2%)                                             
      Serosa, Hemangiosarcoma                                                    1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant                               2 (4%)       2 (4%)       2 (4%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04  
Route: SKIN APPLICATION                                                                                           Time: 09:11:56  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42          42          42          41                                       
     Total Primary Neoplasms                           75          71          74          78                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          31          33          31                                       
     Total Benign Neoplasms                            44          46          47          45                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              27          21          22          23                                       
     Total Malignant Neoplasms                         31          25          27          33                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              8           6           4           8                                       
     Total Metastatic Neoplasm                         16          11          12          22                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   2                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.