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TDMS Study 93020-08 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                             DIISOPROPYLCARBODIIMIDE                                DATE: 07/19/04       
EXPERIMENT: 93020 TEST: 08                                                                                     TIME: 09:14:52       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05451                              ROUTE: SKIN APPLICATION                                        NTP C#: 93020D       
PATHOLOGIST: FARNELL, DANIEL                                                                                   CAS: 693-13-0        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                             DIISOPROPYLCARBODIIMIDE                                DATE: 07/19/04       
EXPERIMENT: 93020 TEST: 08                                                                                     TIME: 09:14:52       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05451                              ROUTE: SKIN APPLICATION                                        NTP C#: 93020D       
PATHOLOGIST: FARNELL, DANIEL                                                                                   CAS: 693-13-0        
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Prostate                                                                           
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                             DIISOPROPYLCARBODIIMIDE                                DATE: 07/19/04       
EXPERIMENT: 93020 TEST: 08                                                                                     TIME: 09:14:52       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05451                              ROUTE: SKIN APPLICATION                                        NTP C#: 93020D       
PATHOLOGIST: FARNELL, DANIEL                                                                                   CAS: 693-13-0        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                DIISOPROPYLCARBODIIMIDE                                                                           
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Liver                                  Hepatocellular Carcinoma                                                                     
                                       Hepatocellular Carcinoma or Hepatoblastoma                                                   
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Harderian Gland                        Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma                                                                     
                                       Hepatocellular Carcinoma or Hepatoblastoma                                                   
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Carcinoma                                                               
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
Uterus                                 Leiomyosarcoma                                                                               
                                       Polyp Stromal                                                                                
                                       Sarcoma Stromal or Polyp Stromal                                                             
All Organs                             Hemangiosarcoma                                                                              
                                       Hemangiosarcoma or Hemangioma                                                                
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                 DIISOPROPYLCARBODIIMIDE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    6/50 (12%)   5/49 (10%)  |0/50 (0%)    0/50 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/47.01      3/46.01      6/44.90      5/43.04     |0/42.68      0/43.63      0/43.22      1/45.13      | 
|POLY-3 PERCENT (g) |     10.6%        6.5%         13.4%        11.6%       |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     4/39 (10%)   3/40 (8%)    5/38 (13%)   4/36 (11%)  |0/33 (0%)    0/33 (0%)    0/38 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     682          729 (T)      713          642         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.388      P=0.347N     P=0.479      P=0.576     |P=0.225      (e)          (e)          P=0.538      | 
|POLY 3             |     P=0.391      P=0.368N     P=0.468      P=0.574     |P=0.206      (e)          (e)          P=0.511      | 
|POLY 1.5           |     P=0.399      P=0.368N     P=0.470      P=0.580     |P=0.203      (e)          (e)          P=0.508      | 
|POLY 6             |     P=0.386      P=0.368N     P=0.466      P=0.569     |P=0.210      (e)          (e)          P=0.515      | 
|LOGISTIC REGRESSION|     P=0.383      P=0.364N     P=0.468      P=0.575     |(e)          (e)          (e)          P=0.538      | 
|COCH-ARM / FISHERS |     P=0.437      P=0.357N     P=0.500      P=0.617     |P=0.199      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.435      (e)          (e)          (e)         |P=0.131      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/46.28      0/46.01      1/44.84      2/43.80     |1/42.52      0/43.63      0/44.22      0/44.17      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         4.6%        |2.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    1/38 (3%)    1/36 (3%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      642         |683          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.063      (e)          P=0.495      P=0.226     |P=0.295N     P=0.500N     P=0.485N     P=0.485N     | 
|POLY 3             |     P=0.064      (e)          P=0.494      P=0.225     |P=0.309N     P=0.495N     P=0.492N     P=0.492N     | 
|POLY 1.5           |     P=0.065      (e)          P=0.495      P=0.228     |P=0.309N     P=0.494N     P=0.494N     P=0.494N     | 
|POLY 6             |     P=0.063      (e)          P=0.493      P=0.222     |P=0.307N     P=0.499N     P=0.490N     P=0.490N     | 
|LOGISTIC REGRESSION|     P=0.068      (e)          P=0.495      P=0.243     |P=0.305N     P=0.496N     P=0.496N     P=0.500N     | 
|COCH-ARM / FISHERS |     P=0.071      (e)          P=0.505      P=0.253     |P=0.305N     P=0.495N     P=0.495N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.067      (e)          (e)          (e)         |P=0.113N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   9/50 (18%)   10/50 (20%)  8/50 (16%)  |9/50 (18%)   5/50 (10%)   5/50 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     9/46.92      9/46.27      10/45.36     8/44.20     |9/43.07      5/43.63      5/44.22      3/46.01      | 
|POLY-3 PERCENT (g) |     19.2%        19.5%        22.1%        18.1%       |20.9%        11.5%        11.3%        6.5%         | 
|TERMINAL (d)       |     8/39 (21%)   8/40 (20%)   8/38 (21%)   7/36 (19%)  |8/33 (24%)   5/33 (15%)   5/39 (13%)   1/40 (3%)    | 
|FIRST INCIDENCE    |     706          660          625          474         |619          729 (T)      729 (T)      582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.540N     P=0.583N     P=0.473      P=0.571N    |P=0.026N*    P=0.188N     P=0.117N     P=0.037N*    | 
|POLY 3             |     P=0.511N     P=0.590      P=0.467      P=0.554N    |P=0.042N*    P=0.183N     P=0.176N     P=0.045N*    | 
|POLY 1.5           |     P=0.502N     P=0.587      P=0.465      P=0.546N    |P=0.046N*    P=0.183N     P=0.185N     P=0.050N     | 
|POLY 6             |     P=0.522N     P=0.596      P=0.473      P=0.563N    |P=0.036N*    P=0.192N     P=0.168N     P=0.040N*    | 
|LOGISTIC REGRESSION|     P=0.518N     P=0.591      P=0.458      P=0.557N    |P=0.044N*    P=0.192N     P=0.159N     P=0.056N     | 
|COCH-ARM / FISHERS |     P=0.450N     P=0.602N     P=0.500      P=0.500N    |P=0.054N     P=0.194N     P=0.194N     P=0.061N     | 
|ORDER RESTRICTED   |     P=0.622N     (e)          (e)          (e)         |P=0.026N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    4/50 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.84      1/46.01      0/44.84      3/43.48     |1/43.11      0/43.63      4/44.63      1/45.13      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         0.0%         6.9%        |2.3%         0.0%         9.0%         2.2%         | 
|TERMINAL (d)       |     1/39 (3%)    1/40 (3%)    0/38 (0%)    3/36 (8%)   |0/33 (0%)    0/33 (0%)    3/39 (8%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     725          729 (T)      ---          729 (T)     |603          ---          614          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.304      P=0.494N     P=0.248N     P=0.461     |P=0.501      P=0.500N     P=0.216      P=0.737N     | 
|POLY 3             |     P=0.322      P=0.506N     P=0.247N     P=0.466     |P=0.470      P=0.498N     P=0.189      P=0.750N     | 
|POLY 1.5           |     P=0.325      P=0.507N     P=0.247N     P=0.472     |P=0.461      P=0.497N     P=0.184      P=0.753N     | 
|POLY 6             |     P=0.319      P=0.505N     P=0.247N     P=0.460     |P=0.483      P=0.502N     P=0.195      P=0.748N     | 
|LOGISTIC REGRESSION|     P=0.298      P=0.504N     P=0.248N     P=0.451     |P=0.448      P=0.509N     P=0.180      P=0.758      | 
|COCH-ARM / FISHERS |     P=0.337      P=0.500N     P=0.247N     P=0.500     |P=0.444      P=0.500N     P=0.181      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.164      (e)          (e)          (e)         |P=0.194      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  10/50 (20%)  10/50 (20%)  11/50 (22%) |10/50 (20%)  5/50 (10%)   8/50 (16%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     10/46.94     10/46.27     10/45.36     11/44.20    |10/43.50     5/43.63      8/44.63      4/46.01      | 
|POLY-3 PERCENT (g) |     21.3%        21.6%        22.1%        24.9%       |23.0%        11.5%        17.9%        8.7%         | 
|TERMINAL (d)       |     8/39 (21%)   9/40 (23%)   8/38 (21%)   10/36 (28%) |8/33 (24%)   5/33 (15%)   7/39 (18%)   2/40 (5%)    | 
|FIRST INCIDENCE    |     706          660          625          474         |603          729 (T)      614          582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.347      P=0.578N     P=0.568      P=0.419     |P=0.050N     P=0.129N     P=0.279N     P=0.045N*    | 
|POLY 3             |     P=0.378      P=0.585      P=0.566      P=0.438     |P=0.076N     P=0.125N     P=0.373N     P=0.056N     | 
|POLY 1.5           |     P=0.387      P=0.582      P=0.563      P=0.447     |P=0.084N     P=0.123N     P=0.386N     P=0.061N     | 
|POLY 6             |     P=0.366      P=0.591      P=0.572      P=0.427     |P=0.065N     P=0.136N     P=0.361N     P=0.051N     | 
|LOGISTIC REGRESSION|     P=0.364      P=0.587      P=0.557      P=0.426     |P=0.084N     P=0.122N     P=0.371N     P=0.069N     | 
|COCH-ARM / FISHERS |     P=0.441      P=0.598N     P=0.598N     P=0.500     |P=0.098N     P=0.131N     P=0.398N     P=0.074N     | 
|ORDER RESTRICTED   |     P=0.536      (e)          (e)          (e)         |P=0.040N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      3/45.12      1/43.48     |0/42.68      0/43.63      1/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         6.7%         2.3%        |0.0%         0.0%         2.3%         2.2%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    2/38 (5%)    1/36 (3%)   |0/33 (0%)    0/33 (0%)    1/39 (3%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          653          729 (T)     |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.226      (e)          P=0.119      P=0.484     |P=0.274      (e)          P=0.533      P=0.538      | 
|POLY 3             |     P=0.215      (e)          P=0.112      P=0.485     |P=0.250      (e)          P=0.507      P=0.511      | 
|POLY 1.5           |     P=0.221      (e)          P=0.112      P=0.488     |P=0.246      (e)          P=0.503      P=0.508      | 
|POLY 6             |     P=0.208      (e)          P=0.113      P=0.483     |P=0.258      (e)          P=0.511      P=0.515      | 
|LOGISTIC REGRESSION|     P=0.234      (e)          P=0.116      P=0.484     |(e)          (e)          P=0.533      P=0.538      | 
|COCH-ARM / FISHERS |     P=0.247      (e)          P=0.121      P=0.500     |P=0.236      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.108      (e)          (e)          (e)         |P=0.258      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    4/50 (8%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.83      1/46.45      4/45.12      1/43.48     |1/42.68      1/43.63      1/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     2.1%         2.2%         8.9%         2.3%        |2.3%         2.3%         2.3%         2.2%         | 
|TERMINAL (d)       |     1/39 (3%)    0/40 (0%)    3/38 (8%)    1/36 (3%)   |1/33 (3%)    1/33 (3%)    1/39 (3%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      603          653          729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.491      P=0.755N     P=0.174      P=0.744     |P=0.570N     P=0.762      P=0.724N     P=0.718N     | 
|POLY 3             |     P=0.478      P=0.759      P=0.168      P=0.744     |P=0.621N     P=0.756N     P=0.753N     P=0.748N     | 
|POLY 1.5           |     P=0.488      P=0.757      P=0.168      P=0.747     |P=0.625N     P=0.756N     P=0.757N     P=0.752N     | 
|POLY 6             |     P=0.467      P=0.760N     P=0.169      P=0.741     |P=0.614N     P=0.759N     P=0.749N     P=0.744N     | 
|LOGISTIC REGRESSION|     P=0.516      P=0.747N     P=0.168      P=0.744     |P=0.570N     P=0.762      P=0.724N     P=0.718N     | 
|COCH-ARM / FISHERS |     P=0.526      P=0.753N     P=0.181      P=0.753N    |P=0.634      P=0.753N     P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.307      (e)          (e)          (e)         |P=0.730N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    2/49 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.28      1/46.01      0/44.29      1/43.48     |0/42.68      2/43.17      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         0.0%         2.3%        |0.0%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    1/40 (3%)    0/38 (0%)    1/36 (3%)   |0/33 (0%)    1/33 (3%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |---          625          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.640N     P=0.756N     P=0.505N     P=0.744     |P=0.382N     P=0.242      (e)          (e)          | 
|POLY 3             |     P=0.619N     P=0.759      P=0.509N     P=0.747     |P=0.388N     P=0.240      (e)          (e)          | 
|POLY 1.5           |     P=0.618N     P=0.760      P=0.508N     P=0.750     |P=0.392N     P=0.238      (e)          (e)          | 
|POLY 6             |     P=0.620N     P=0.759      P=0.509N     P=0.742     |P=0.384N     P=0.238      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.640N     P=0.756N     (e)          P=0.744     |P=0.405N     P=0.233      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.612N     P=0.747N     P=0.500N     P=0.747N    |P=0.404N     P=0.242      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.554N     (e)          (e)          (e)         |P=0.239N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    1/49 (2%)    1/50 (2%)   |0/50 (0%)    2/49 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.28      1/46.01      1/44.66      1/43.48     |0/42.68      2/43.17      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         2.2%         2.3%        |0.0%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    1/40 (3%)    0/38 (0%)    1/36 (3%)   |0/33 (0%)    1/33 (3%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      625          729 (T)     |---          625          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.610      P=0.756N     P=0.755      P=0.744     |P=0.382N     P=0.242      (e)          (e)          | 
|POLY 3             |     P=0.609      P=0.759      P=0.753      P=0.747     |P=0.388N     P=0.240      (e)          (e)          | 
|POLY 1.5           |     P=0.614      P=0.760      P=0.752      P=0.750     |P=0.392N     P=0.238      (e)          (e)          | 
|POLY 6             |     P=0.602      P=0.759      P=0.754      P=0.742     |P=0.384N     P=0.238      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.629      P=0.756N     P=0.755N     P=0.744     |P=0.405N     P=0.233      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.630N     P=0.747N     P=0.753N     P=0.747N    |P=0.404N     P=0.242      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.728      (e)          (e)          (e)         |P=0.239N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    1/49 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.83      2/46.01      1/44.84      1/42.92     |1/42.68      1/43.76      0/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         2.2%         2.3%        |2.3%         2.3%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/39 (0%)    2/40 (5%)    1/38 (3%)    0/36 (0%)   |1/33 (3%)    0/33 (0%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      674         |729 (T)      695          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.472      P=0.244      P=0.495      P=0.481     |P=0.568N     P=0.754      P=0.467N     P=0.718N     | 
|POLY 3             |     P=0.463      P=0.233      P=0.491      P=0.483     |P=0.610N     P=0.755N     P=0.493N     P=0.748N     | 
|POLY 1.5           |     P=0.467      P=0.233      P=0.492      P=0.484     |P=0.613N     P=0.756N     P=0.497N     P=0.752N     | 
|POLY 6             |     P=0.460      P=0.234      P=0.491      P=0.481     |P=0.607N     P=0.758N     P=0.489N     P=0.744N     | 
|LOGISTIC REGRESSION|     P=0.474      P=0.244      P=0.495      P=0.507     |P=0.597N     P=0.760N     (e)          P=0.718N     | 
|COCH-ARM / FISHERS |     P=0.494      P=0.247      P=0.500      P=0.495     |P=0.616N     P=0.753N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.271      (e)          (e)          (e)         |P=0.520N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/50 (36%)  22/50 (44%)  19/50 (38%)  19/49 (39%) |21/50 (42%)  27/50 (54%)  21/50 (42%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     18/46.83     22/46.67     19/45.74     19/43.91    |21/43.39     27/44.95     21/44.66     18/45.56     | 
|POLY-3 PERCENT (g) |     38.4%        47.1%        41.5%        43.3%       |48.4%        60.1%        47.0%        39.5%        | 
|TERMINAL (d)       |     18/39 (46%)  20/40 (50%)  16/38 (42%)  17/36 (47%) |19/33 (58%)  22/33 (67%)  20/39 (51%)  16/40 (40%)  | 
|FIRST INCIDENCE    |     729 (T)      603          493          498         |603          579          603          619          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.400      P=0.295      P=0.457      P=0.373     |P=0.025N*    P=0.146      P=0.311N     P=0.122N     | 
|POLY 3             |     P=0.442      P=0.260      P=0.463      P=0.399     |P=0.100N     P=0.181      P=0.534N     P=0.262N     | 
|POLY 1.5           |     P=0.446      P=0.251      P=0.454      P=0.401     |P=0.118N     P=0.179      P=0.560N     P=0.285N     | 
|POLY 6             |     P=0.441      P=0.275      P=0.477      P=0.402     |P=0.081N     P=0.169      P=0.510N     P=0.239N     | 
|LOGISTIC REGRESSION|     P=0.401      P=0.246      P=0.432      P=0.354     |P=0.078N     P=0.151      P=0.487N     P=0.230N     | 
|COCH-ARM / FISHERS |     P=0.524      P=0.270      P=0.500      P=0.469     |P=0.161N     P=0.158      P=0.580N     P=0.341N     | 
|ORDER RESTRICTED   |     P=0.467      (e)          (e)          (e)         |P=0.117N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     20/50 (40%)  15/50 (30%)  11/50 (22%)  11/49 (22%) |10/50 (20%)  2/50 (4%)    8/50 (16%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     20/49.51     15/48.49     11/46.88     11/44.48    |10/43.35     2/43.63      8/45.04      3/45.17      | 
|POLY-3 PERCENT (g) |     40.4%        30.9%        23.5%        24.7%       |23.1%        4.6%         17.8%        6.6%         | 
|TERMINAL (d)       |     12/39 (31%)  8/40 (20%)   4/38 (11%)   6/36 (17%)  |6/33 (18%)   2/33 (6%)    7/39 (18%)   2/40 (5%)    | 
|FIRST INCIDENCE    |     515          435          496          474         |619          729 (T)      417          718          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.079N     P=0.226N     P=0.080N     P=0.099N    |P=0.044N*    P=0.019N*    P=0.286N     P=0.021N*    | 
|POLY 3             |     P=0.057N     P=0.222N     P=0.058N     P=0.081N    |P=0.067N     P=0.012N*    P=0.362N     P=0.028N*    | 
|POLY 1.5           |     P=0.051N     P=0.223N     P=0.056N     P=0.072N    |P=0.072N     P=0.012N*    P=0.377N     P=0.030N*    | 
|POLY 6             |     P=0.064N     P=0.220N     P=0.058N     P=0.091N    |P=0.060N     P=0.014N*    P=0.351N     P=0.026N*    | 
|LOGISTIC REGRESSION|     P=0.027N*    P=0.165N     P=0.031N*    P=0.038N*   |P=0.071N     P=0.014N*    P=0.382N     P=0.028N*    | 
|COCH-ARM / FISHERS |     P=0.034N*    P=0.201N     P=0.041N*    P=0.047N*   |P=0.083N     P=0.014N*    P=0.398N     P=0.036N*    | 
|ORDER RESTRICTED   |     P=0.063N     (e)          (e)          (e)         |P=0.012N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     20/50 (40%)  16/50 (32%)  11/50 (22%)  11/49 (22%) |10/50 (20%)  2/50 (4%)    8/50 (16%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     20/49.51     16/48.49     11/46.88     11/44.48    |10/43.35     2/43.63      8/45.04      3/45.17      | 
|POLY-3 PERCENT (g) |     40.4%        33.0%        23.5%        24.7%       |23.1%        4.6%         17.8%        6.6%         | 
|TERMINAL (d)       |     12/39 (31%)  9/40 (23%)   4/38 (11%)   6/36 (17%)  |6/33 (18%)   2/33 (6%)    7/39 (18%)   2/40 (5%)    | 
|FIRST INCIDENCE    |     515          435          496          474         |619          729 (T)      417          718          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.071N     P=0.285N     P=0.080N     P=0.099N    |P=0.044N*    P=0.019N*    P=0.286N     P=0.021N*    | 
|POLY 3             |     P=0.050N     P=0.292N     P=0.058N     P=0.081N    |P=0.067N     P=0.012N*    P=0.362N     P=0.028N*    | 
|POLY 1.5           |     P=0.044N*    P=0.292N     P=0.056N     P=0.072N    |P=0.072N     P=0.012N*    P=0.377N     P=0.030N*    | 
|POLY 6             |     P=0.056N     P=0.289N     P=0.058N     P=0.091N    |P=0.060N     P=0.014N*    P=0.351N     P=0.026N*    | 
|LOGISTIC REGRESSION|     P=0.023N*    P=0.226N     P=0.031N*    P=0.038N*   |P=0.071N     P=0.014N*    P=0.382N     P=0.028N*    | 
|COCH-ARM / FISHERS |     P=0.029N*    P=0.266N     P=0.041N*    P=0.047N*   |P=0.083N     P=0.014N*    P=0.398N     P=0.036N*    | 
|ORDER RESTRICTED   |     P=0.064N     (e)          (e)          (e)         |P=0.012N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     35/50 (70%)  33/50 (66%)  29/50 (58%)  29/49 (59%) |29/50 (58%)  29/50 (58%)  26/50 (52%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     35/49.51     33/48.92     29/47.63     29/45.68    |29/44.06     29/44.95     26/45.47     20/45.56     | 
|POLY-3 PERCENT (g) |     70.7%        67.5%        60.9%        63.5%       |65.8%        64.5%        57.2%        43.9%        | 
|TERMINAL (d)       |     27/39 (69%)  25/40 (63%)  20/38 (53%)  22/36 (61%) |23/33 (70%)  24/33 (73%)  24/39 (62%)  18/40 (45%)  | 
|FIRST INCIDENCE    |     515          435          493          474         |603          579          417          619          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.308N     P=0.395N     P=0.253N     P=0.340N    |P<0.001N**   P=0.575      P=0.109N     P=0.008N**   | 
|POLY 3             |     P=0.236N     P=0.449N     P=0.210N     P=0.297N    |P=0.011N*    P=0.538N     P=0.262N     P=0.026N*    | 
|POLY 1.5           |     P=0.219N     P=0.459N     P=0.213N     P=0.280N    |P=0.015N*    P=0.537N     P=0.295N     P=0.032N*    | 
|POLY 6             |     P=0.259N     P=0.428N     P=0.202N     P=0.319N    |P=0.008N**   P=0.579N     P=0.244N     P=0.023N*    | 
|LOGISTIC REGRESSION|     P=0.175N     P=0.415N     P=0.172N     P=0.228N    |P=0.008N**   P=0.554N     P=0.262N     P=0.020N*    | 
|COCH-ARM / FISHERS |     P=0.135N     P=0.415N     P=0.149N     P=0.180N    |P=0.028N*    P=0.580N     P=0.344N     P=0.055N     | 
|ORDER RESTRICTED   |     P=0.303N     (e)          (e)          (e)         |P=0.020N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     35/50 (70%)  33/50 (66%)  29/50 (58%)  29/49 (59%) |29/50 (58%)  29/50 (58%)  26/50 (52%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     35/49.51     33/48.92     29/47.63     29/45.68    |29/44.06     29/44.95     26/45.47     20/45.56     | 
|POLY-3 PERCENT (g) |     70.7%        67.5%        60.9%        63.5%       |65.8%        64.5%        57.2%        43.9%        | 
|TERMINAL (d)       |     27/39 (69%)  25/40 (63%)  20/38 (53%)  22/36 (61%) |23/33 (70%)  24/33 (73%)  24/39 (62%)  18/40 (45%)  | 
|FIRST INCIDENCE    |     515          435          493          474         |603          579          417          619          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.308N     P=0.395N     P=0.253N     P=0.340N    |P<0.001N**   P=0.575      P=0.109N     P=0.008N**   | 
|POLY 3             |     P=0.236N     P=0.449N     P=0.210N     P=0.297N    |P=0.011N*    P=0.538N     P=0.262N     P=0.026N*    | 
|POLY 1.5           |     P=0.219N     P=0.459N     P=0.213N     P=0.280N    |P=0.015N*    P=0.537N     P=0.295N     P=0.032N*    | 
|POLY 6             |     P=0.259N     P=0.428N     P=0.202N     P=0.319N    |P=0.008N**   P=0.579N     P=0.244N     P=0.023N*    | 
|LOGISTIC REGRESSION|     P=0.175N     P=0.415N     P=0.172N     P=0.228N    |P=0.008N**   P=0.554N     P=0.262N     P=0.020N*    | 
|COCH-ARM / FISHERS |     P=0.135N     P=0.415N     P=0.149N     P=0.180N    |P=0.028N*    P=0.580N     P=0.344N     P=0.055N     | 
|ORDER RESTRICTED   |     P=0.303N     (e)          (e)          (e)         |P=0.020N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   6/50 (12%)   7/50 (14%)   8/50 (16%)  |4/50 (8%)    2/50 (4%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     6/47.28      6/46.01      7/45.05      8/43.48     |4/43.24      2/43.91      3/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     12.7%        13.0%        15.5%        18.4%       |9.3%         4.6%         6.8%         2.2%         | 
|TERMINAL (d)       |     5/39 (13%)   6/40 (15%)   5/38 (13%)   8/36 (22%)  |2/33 (6%)    1/33 (3%)    3/39 (8%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     598          729 (T)      690          729 (T)     |603          653          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.232      P=0.604N     P=0.477      P=0.325     |P=0.121N     P=0.347N     P=0.432N     P=0.144N     | 
|POLY 3             |     P=0.242      P=0.601      P=0.463      P=0.323     |P=0.151N     P=0.330N     P=0.488N     P=0.166N     | 
|POLY 1.5           |     P=0.254      P=0.603      P=0.466      P=0.337     |P=0.155N     P=0.329N     P=0.494N     P=0.169N     | 
|POLY 6             |     P=0.229      P=0.600      P=0.461      P=0.309     |P=0.145N     P=0.337N     P=0.482N     P=0.162N     | 
|LOGISTIC REGRESSION|     P=0.235      P=0.609      P=0.470      P=0.323     |P=0.151N     P=0.332N     P=0.487N     P=0.171N     | 
|COCH-ARM / FISHERS |     P=0.300      P=0.620N     P=0.500      P=0.387     |P=0.162N     P=0.339N     P=0.500N     P=0.181N     | 
|ORDER RESTRICTED   |     P=0.356      (e)          (e)          (e)         |P=0.117N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    4/50 (8%)    2/50 (4%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     2/46.83      3/46.01      4/44.84      2/43.71     |0/42.68      2/43.91      2/44.81      5/45.13      | 
|POLY-3 PERCENT (g) |     4.3%         6.5%         8.9%         4.6%        |0.0%         4.6%         4.5%         11.1%        | 
|TERMINAL (d)       |     2/39 (5%)    3/40 (8%)    4/38 (11%)   1/36 (3%)   |0/33 (0%)    1/33 (3%)    0/39 (0%)    5/40 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      667         |---          653          603          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.558      P=0.512      P=0.324      P=0.663     |P=0.028 *    P=0.240      P=0.248      P=0.052      | 
|POLY 3             |     P=0.559      P=0.492      P=0.317      P=0.669     |P=0.019 *    P=0.243      P=0.248      P=0.035 *    | 
|POLY 1.5           |     P=0.566      P=0.491      P=0.318      P=0.673     |P=0.018 *    P=0.243      P=0.243      P=0.034 *    | 
|POLY 6             |     P=0.552      P=0.493      P=0.317      P=0.666     |P=0.020 *    P=0.241      P=0.255      P=0.037 *    | 
|LOGISTIC REGRESSION|     P=0.558      P=0.512      P=0.324      P=0.672     |P=0.018 *    P=0.240      P=0.237      P=0.052      | 
|COCH-ARM / FISHERS |     P=0.562N     P=0.500      P=0.339      P=0.691N    |P=0.016 *    P=0.247      P=0.247      P=0.028 *    | 
|ORDER RESTRICTED   |     P=0.489      (e)          (e)          (e)         |P=0.012 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   9/50 (18%)   11/50 (22%)  10/50 (20%) |4/50 (8%)    4/50 (8%)    5/50 (10%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     8/47.28      9/46.01      11/45.05     10/43.71    |4/43.24      4/44.19      5/44.81      6/45.13      | 
|POLY-3 PERCENT (g) |     16.9%        19.6%        24.4%        22.9%       |9.3%         9.1%         11.2%        13.3%        | 
|TERMINAL (d)       |     7/39 (18%)   9/40 (23%)   9/38 (24%)   9/36 (25%)  |2/33 (6%)    2/33 (6%)    3/39 (8%)    6/40 (15%)   | 
|FIRST INCIDENCE    |     598          729 (T)      690          667         |603          653          603          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.249      P=0.522      P=0.283      P=0.326     |P=0.375      P=0.634      P=0.565      P=0.478      | 
|POLY 3             |     P=0.260      P=0.476      P=0.264      P=0.327     |P=0.294      P=0.632N     P=0.522      P=0.396      | 
|POLY 1.5           |     P=0.275      P=0.478      P=0.268      P=0.341     |P=0.287      P=0.632N     P=0.511      P=0.390      | 
|POLY 6             |     P=0.247      P=0.473      P=0.261      P=0.314     |P=0.303      P=0.639N     P=0.534      P=0.403      | 
|LOGISTIC REGRESSION|     P=0.251      P=0.486      P=0.268      P=0.326     |P=0.289      P=0.639N     P=0.506      P=0.404      | 
|COCH-ARM / FISHERS |     P=0.335      P=0.500      P=0.306      P=0.398     |P=0.270      P=0.643N     P=0.500      P=0.370      | 
|ORDER RESTRICTED   |     P=0.342      (e)          (e)          (e)         |P=0.421      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.86      0/46.01      0/44.84      0/43.48     |1/42.80      0/43.63      2/44.51      0/45.13      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         0.0%        |2.3%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    1/39 (3%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     721          ---          ---          ---         |698          ---          653          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.322N     P=0.505N     P=0.515N     P=0.526N    |P=0.427N     P=0.511N     P=0.531      P=0.474N     | 
|POLY 3             |     P=0.299N     P=0.504N     P=0.509N     P=0.515N    |P=0.447N     P=0.496N     P=0.514      P=0.489N     | 
|POLY 1.5           |     P=0.300N     P=0.504N     P=0.508N     P=0.512N    |P=0.452N     P=0.496N     P=0.507      P=0.493N     | 
|POLY 6             |     P=0.298N     P=0.503N     P=0.509N     P=0.518N    |P=0.438N     P=0.499N     P=0.521      P=0.486N     | 
|LOGISTIC REGRESSION|     P=0.315N     P=0.503N     P=0.509N     P=0.517N    |P=0.457N     P=0.497N     P=0.503      P=0.495N     | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.461N     P=0.500N     P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.134N     (e)          (e)          (e)         |P=0.315N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/49 (2%)    2/50 (4%)    2/49 (4%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |                                                        |1/41.68      2/43.63      2/43.71      2/44.17      | 
|POLY-3 PERCENT (g) |                                                        |2.4%         4.6%         4.6%         4.5%         | 
|TERMINAL (d)       |                                                        |1/32 (3%)    2/33 (6%)    2/39 (5%)    2/40 (5%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.518      P=0.511      P=0.569      P=0.578      | 
|POLY 3             |                                                        |P=0.448      P=0.516      P=0.517      P=0.520      | 
|POLY 1.5           |                                                        |P=0.438      P=0.515      P=0.508      P=0.514      | 
|POLY 6             |                                                        |P=0.460      P=0.512      P=0.526      P=0.528      | 
|LOGISTIC REGRESSION|                                                        |P=0.518      P=0.511      P=0.569      P=0.578      | 
|COCH-ARM / FISHERS |                                                        |P=0.420      P=0.508      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |                                                        |P=0.486      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/47 (0%)    0/50 (0%)    0/49 (0%)   |4/48 (8%)    12/50 (24%)  3/50 (6%)    10/46 (22%)  | 
|POLY-3 RATE (b)    |     0/44.84      0/43.75      0/44.84      0/42.71     |4/41.44      12/44.68     3/44.22      10/42.13     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |9.7%         26.9%        6.8%         23.7%        | 
|TERMINAL (d)       |     0/38 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |3/32 (9%)    9/33 (27%)   3/39 (8%)    10/38 (26%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |521          540          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.313      P=0.036 *    P=0.405N     P=0.130      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.187      P=0.035 *    P=0.465N     P=0.074      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.177      P=0.035 *    P=0.472N     P=0.070      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.200      P=0.034 *    P=0.458N     P=0.080      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.199      P=0.037 *    P=0.468N     P=0.081      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.164      P=0.033 *    P=0.477N     P=0.062      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.061      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/47 (0%)    0/50 (0%)    0/49 (0%)   |5/48 (10%)   12/50 (24%)  3/50 (6%)    10/46 (22%)  | 
|POLY-3 RATE (b)    |     0/44.84      0/43.75      0/44.84      0/42.71     |5/41.56      12/44.68     3/44.22      10/42.13     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |12.0%        26.9%        6.8%         23.7%        | 
|TERMINAL (d)       |     0/38 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |3/32 (9%)    9/33 (27%)   3/39 (8%)    10/38 (26%)  | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |521          540          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.408      P=0.068      P=0.273N     P=0.217      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.261      P=0.070      P=0.322N     P=0.132      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.250      P=0.070      P=0.329N     P=0.125      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.275      P=0.066      P=0.317N     P=0.140      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.276      P=0.070      P=0.324N     P=0.140      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.233      P=0.065      P=0.335N     P=0.112      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.120      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/47 (0%)    1/50 (2%)    0/49 (0%)   |0/48 (0%)    2/50 (4%)    1/50 (2%)    1/46 (2%)    | 
|POLY-3 RATE (b)    |     0/44.84      0/43.75      1/44.84      0/42.71     |0/40.81      2/43.63      1/44.22      1/42.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |0.0%         4.6%         2.3%         2.4%         | 
|TERMINAL (d)       |     0/38 (0%)    0/40 (0%)    1/38 (3%)    0/36 (0%)   |0/32 (0%)    2/33 (6%)    1/39 (3%)    1/38 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.687      (e)          P=0.500      (e)         |P=0.556      P=0.245      P=0.539      P=0.534      | 
|POLY 3             |     P=0.671      (e)          P=0.500      (e)         |P=0.518      P=0.252      P=0.516      P=0.506      | 
|POLY 1.5           |     P=0.676      (e)          P=0.500      (e)         |P=0.507      P=0.252      P=0.512      P=0.501      | 
|POLY 6             |     P=0.666      (e)          P=0.500      (e)         |P=0.532      P=0.249      P=0.520      P=0.512      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.500      (e)         |(e)          P=0.245      P=0.539      P=0.534      | 
|COCH-ARM / FISHERS |     P=0.699      (e)          P=0.510      (e)         |P=0.484      P=0.258      P=0.510      P=0.489      | 
|ORDER RESTRICTED   |     P=0.381      (e)          (e)          (e)         |P=0.288      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma or Basosquamous Tumor Benign                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      0/44.84      0/43.48     |0/42.68      0/43.63      2/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    2/39 (5%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.637      (e)          P=0.276      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.622      (e)          P=0.245      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.613      (e)          P=0.241      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.634      (e)          P=0.249      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.276      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.595      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.254      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           | 
|     Trichoepithelioma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      0/44.84      0/43.48     |0/42.68      0/43.63      2/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    2/39 (5%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.637      (e)          P=0.276      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.622      (e)          P=0.245      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.613      (e)          P=0.241      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.634      (e)          P=0.249      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.276      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.595      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.254      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      0/44.84      0/43.48     |0/42.68      0/43.63      2/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    2/39 (5%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.637      (e)          P=0.276      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.622      (e)          P=0.245      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.613      (e)          P=0.241      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.634      (e)          P=0.249      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.276      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.595      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.254      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      0/44.84      0/43.48     |0/42.68      0/43.63      3/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         6.8%         2.2%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    3/39 (8%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.303      (e)          P=0.152      P=0.538      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.269      (e)          P=0.125      P=0.511      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.261      (e)          P=0.122      P=0.508      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.281      (e)          P=0.128      P=0.515      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.152      P=0.538      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.247      (e)          P=0.121      P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.121      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.83      1/46.24      0/44.84      0/43.48     |1/42.96      2/43.63      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     2.1%         2.2%         0.0%         0.0%        |2.3%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    2/33 (6%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      670          ---          ---         |653          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.252N     P=0.760N     P=0.505N     P=0.516N    |P=0.165N     P=0.500      P=0.495N     P=0.495N     | 
|POLY 3             |     P=0.242N     P=0.758      P=0.509N     P=0.515N    |P=0.181N     P=0.505      P=0.494N     P=0.490N     | 
|POLY 1.5           |     P=0.241N     P=0.757      P=0.508N     P=0.512N    |P=0.183N     P=0.506      P=0.497N     P=0.493N     | 
|POLY 6             |     P=0.242N     P=0.759      P=0.509N     P=0.517N    |P=0.180N     P=0.499      P=0.491N     P=0.487N     | 
|LOGISTIC REGRESSION|     P=0.238N     P=0.762N     (e)          (e)         |P=0.182N     P=0.506      P=0.501N     P=0.508N     | 
|COCH-ARM / FISHERS |     P=0.236N     P=0.753N     P=0.500N     P=0.500N    |P=0.188N     P=0.500      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.264N     (e)          (e)          (e)         |P=0.161N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      0/44.84      0/43.48     |2/43.11      1/43.63      0/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.6%         2.3%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |1/33 (3%)    1/33 (3%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |603          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.322N     P=0.500N     P=0.221N     P=0.453N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.363N     P=0.496N     P=0.231N     P=0.484N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.365N     P=0.495N     P=0.235N     P=0.489N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.359N     P=0.503N     P=0.228N     P=0.480N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.360N     P=0.497N     P=0.238N     P=0.498N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.366N     P=0.500N     P=0.247N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.211N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      0/44.84      1/43.48     |2/43.04      1/43.91      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |4.7%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    1/36 (3%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |681          653          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187      (e)          (e)          P=0.484     |P=0.096N     P=0.503N     P=0.226N     P=0.226N     | 
|POLY 3             |     P=0.190      (e)          (e)          P=0.485     |P=0.099N     P=0.493N     P=0.231N     P=0.227N     | 
|POLY 1.5           |     P=0.192      (e)          (e)          P=0.488     |P=0.100N     P=0.493N     P=0.234N     P=0.230N     | 
|POLY 6             |     P=0.188      (e)          (e)          P=0.483     |P=0.098N     P=0.498N     P=0.228N     P=0.224N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.484     |P=0.101N     P=0.502N     P=0.237N     P=0.237N     | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.101N     P=0.500N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.108      (e)          (e)          (e)         |P=0.067N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    1/50 (2%)    2/47 (4%)   |1/49 (2%)    1/49 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.28      0/46.01      1/44.84      2/41.10     |1/42.14      1/43.04      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         4.9%        |2.4%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    1/38 (3%)    1/35 (3%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      642         |683          695          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.061      (e)          P=0.495      P=0.223     |P=0.221N     P=0.754      P=0.485N     P=0.485N     | 
|POLY 3             |     P=0.057      (e)          P=0.494      P=0.211     |P=0.230N     P=0.756N     P=0.490N     P=0.486N     | 
|POLY 1.5           |     P=0.058      (e)          P=0.495      P=0.214     |P=0.231N     P=0.756N     P=0.493N     P=0.489N     | 
|POLY 6             |     P=0.056      (e)          P=0.493      P=0.209     |P=0.229N     P=0.759N     P=0.488N     P=0.484N     | 
|LOGISTIC REGRESSION|     P=0.061      (e)          P=0.495      P=0.228     |P=0.230N     P=0.761N     P=0.495N     P=0.496N     | 
|COCH-ARM / FISHERS |     P=0.064      (e)          P=0.505      P=0.237     |P=0.232N     P=0.753N     P=0.495N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.059      (e)          (e)          (e)         |P=0.238N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/46.94      1/46.01      1/44.84      2/43.48     |1/42.68      1/44.02      2/44.22      2/45.13      | 
|POLY-3 PERCENT (g) |     2.1%         2.2%         2.2%         4.6%        |2.3%         2.3%         4.5%         4.4%         | 
|TERMINAL (d)       |     0/39 (0%)    1/40 (3%)    1/38 (3%)    2/36 (6%)   |1/33 (3%)    0/33 (0%)    2/39 (5%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     702          729 (T)      729 (T)      729 (T)     |729 (T)      617          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.320      P=0.758      P=0.749      P=0.467     |P=0.403      P=0.755N     P=0.558      P=0.567      | 
|POLY 3             |     P=0.328      P=0.756      P=0.750      P=0.473     |P=0.358      P=0.754N     P=0.512      P=0.519      | 
|POLY 1.5           |     P=0.332      P=0.756      P=0.751      P=0.478     |P=0.351      P=0.755N     P=0.506      P=0.513      | 
|POLY 6             |     P=0.322      P=0.756      P=0.750      P=0.468     |P=0.368      P=0.756N     P=0.519      P=0.526      | 
|LOGISTIC REGRESSION|     P=0.320      P=0.759      P=0.754      P=0.471     |P=0.354      P=0.762      P=0.558      P=0.567      | 
|COCH-ARM / FISHERS |     P=0.351      P=0.753N     P=0.753N     P=0.500     |P=0.337      P=0.753N     P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.380      (e)          (e)          (e)         |P=0.457      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/46.94      1/46.01      1/44.84      1/43.48     |1/42.68      1/44.02      1/44.22      2/45.13      | 
|POLY-3 PERCENT (g) |     2.1%         2.2%         2.2%         2.3%        |2.3%         2.3%         2.3%         4.4%         | 
|TERMINAL (d)       |     0/39 (0%)    1/40 (3%)    1/38 (3%)    1/36 (3%)   |1/33 (3%)    0/33 (0%)    1/39 (3%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     702          729 (T)      729 (T)      729 (T)     |729 (T)      617          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.606      P=0.758      P=0.749      P=0.738     |P=0.409      P=0.755N     P=0.724N     P=0.567      | 
|POLY 3             |     P=0.606      P=0.756      P=0.750      P=0.743     |P=0.368      P=0.754N     P=0.753N     P=0.519      | 
|POLY 1.5           |     P=0.612      P=0.756      P=0.751      P=0.747     |P=0.362      P=0.755N     P=0.757N     P=0.513      | 
|POLY 6             |     P=0.601      P=0.756      P=0.750      P=0.740     |P=0.376      P=0.756N     P=0.749N     P=0.526      | 
|LOGISTIC REGRESSION|     P=0.609      P=0.759      P=0.754      P=0.747     |P=0.363      P=0.762      P=0.724N     P=0.567      | 
|COCH-ARM / FISHERS |     P=0.634      P=0.753N     P=0.753N     P=0.753N    |P=0.351      P=0.753N     P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.723      (e)          (e)          (e)         |P=0.435      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.28      1/46.01      0/44.84      1/43.55     |3/42.68      0/43.63      0/44.22      2/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         2.3%        |7.0%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/39 (0%)    1/40 (3%)    0/38 (0%)    0/36 (0%)   |3/33 (9%)    0/33 (0%)    0/39 (0%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          712         |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.385      P=0.505      (e)          P=0.480     |P=0.458N     P=0.120N     P=0.093N     P=0.412N     | 
|POLY 3             |     P=0.386      P=0.499      (e)          P=0.488     |P=0.532N     P=0.114N     P=0.112N     P=0.475N     | 
|POLY 1.5           |     P=0.391      P=0.499      (e)          P=0.491     |P=0.533N     P=0.115N     P=0.116N     P=0.483N     | 
|POLY 6             |     P=0.382      P=0.498      (e)          P=0.485     |P=0.526N     P=0.116N     P=0.109N     P=0.466N     | 
|LOGISTIC REGRESSION|     P=0.389      P=0.505      (e)          P=0.491     |P=0.458N     (e)          (e)          P=0.412N     | 
|COCH-ARM / FISHERS |     P=0.408      P=0.505      (e)          P=0.505     |P=0.531N     P=0.121N     P=0.121N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.240      (e)          (e)          (e)         |P=0.089N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Leiomyosarcoma                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |0/42.68      0/43.63      0/44.22      2/45.13      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |                                                        |0/33 (0%)    0/33 (0%)    0/39 (0%)    2/40 (5%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.060      (e)          (e)          P=0.282      | 
|POLY 3             |                                                        |P=0.047 *    (e)          (e)          P=0.250      | 
|POLY 1.5           |                                                        |P=0.047 *    (e)          (e)          P=0.246      | 
|POLY 6             |                                                        |P=0.049 *    (e)          (e)          P=0.254      | 
|LOGISTIC REGRESSION|                                                        |(e)          (e)          (e)          P=0.282      | 
|COCH-ARM / FISHERS |                                                        |P=0.046 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |                                                        |P=0.034 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |4/50 (8%)    2/50 (4%)    5/50 (10%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |4/42.96      2/43.63      5/44.66      0/45.13      | 
|POLY-3 PERCENT (g) |                                                        |9.3%         4.6%         11.2%        0.0%         | 
|TERMINAL (d)       |                                                        |3/33 (9%)    2/33 (6%)    4/39 (10%)   0/40 (0%)    | 
|FIRST INCIDENCE    |                                                        |654          729 (T)      603          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.063N     P=0.341N     P=0.582      P=0.047N*    | 
|POLY 3             |                                                        |P=0.081N     P=0.330N     P=0.524      P=0.054N     | 
|POLY 1.5           |                                                        |P=0.086N     P=0.329N     P=0.512      P=0.056N     | 
|POLY 6             |                                                        |P=0.076N     P=0.338N     P=0.537      P=0.052N     | 
|LOGISTIC REGRESSION|                                                        |P=0.085N     P=0.332N     P=0.515      P=0.056N     | 
|COCH-ARM / FISHERS |                                                        |P=0.095N     P=0.339N     P=0.500      P=0.059N     | 
|ORDER RESTRICTED   |                                                        |P=0.049N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |4/50 (8%)    2/50 (4%)    5/50 (10%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |4/42.96      2/43.63      5/44.66      0/45.13      | 
|POLY-3 PERCENT (g) |                                                        |9.3%         4.6%         11.2%        0.0%         | 
|TERMINAL (d)       |                                                        |3/33 (9%)    2/33 (6%)    4/39 (10%)   0/40 (0%)    | 
|FIRST INCIDENCE    |                                                        |654          729 (T)      603          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.063N     P=0.341N     P=0.582      P=0.047N*    | 
|POLY 3             |                                                        |P=0.081N     P=0.330N     P=0.524      P=0.054N     | 
|POLY 1.5           |                                                        |P=0.086N     P=0.329N     P=0.512      P=0.056N     | 
|POLY 6             |                                                        |P=0.076N     P=0.338N     P=0.537      P=0.052N     | 
|LOGISTIC REGRESSION|                                                        |P=0.085N     P=0.332N     P=0.515      P=0.056N     | 
|COCH-ARM / FISHERS |                                                        |P=0.095N     P=0.339N     P=0.500      P=0.059N     | 
|ORDER RESTRICTED   |                                                        |P=0.049N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.83      0/46.01      1/44.84      0/43.48     |2/43.11      2/43.63      0/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         2.2%         0.0%        |4.6%         4.6%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/39 (3%)    0/40 (0%)    1/38 (3%)    0/36 (0%)   |1/33 (3%)    2/33 (6%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |603          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.423N     P=0.495N     P=0.756      P=0.516N    |P=0.249N     P=0.694      P=0.221N     P=0.453N     | 
|POLY 3             |     P=0.415N     P=0.504N     P=0.751      P=0.515N    |P=0.289N     P=0.690N     P=0.231N     P=0.484N     | 
|POLY 1.5           |     P=0.413N     P=0.504N     P=0.751      P=0.512N    |P=0.292N     P=0.688N     P=0.235N     P=0.489N     | 
|POLY 6             |     P=0.418N     P=0.503N     P=0.751      P=0.517N    |P=0.285N     P=0.692      P=0.228N     P=0.480N     | 
|LOGISTIC REGRESSION|     P=0.423N     (e)          P=0.756      (e)         |P=0.286N     P=0.690N     P=0.238N     P=0.498N     | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.500N     P=0.753N     P=0.500N    |P=0.296N     P=0.691N     P=0.247N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.266N     (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    4/50 (8%)    3/50 (6%)   |4/50 (8%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.83      2/46.01      4/44.84      3/44.01     |4/43.04      2/44.04      0/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         8.9%         6.8%        |9.3%         4.5%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/39 (0%)    2/40 (5%)    4/38 (11%)   1/36 (3%)   |2/33 (6%)    0/33 (0%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      642         |681          653          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.094      P=0.244      P=0.060      P=0.111     |P=0.071N     P=0.347N     P=0.052N     P=0.144N     | 
|POLY 3             |     P=0.094      P=0.233      P=0.055      P=0.108     |P=0.082N     P=0.326N     P=0.057N     P=0.164N     | 
|POLY 1.5           |     P=0.096      P=0.233      P=0.055      P=0.109     |P=0.084N     P=0.327N     P=0.059N     P=0.168N     | 
|POLY 6             |     P=0.092      P=0.234      P=0.055      P=0.107     |P=0.080N     P=0.332N     P=0.055N     P=0.161N     | 
|LOGISTIC REGRESSION|     P=0.098      P=0.244      P=0.060      P=0.121     |P=0.082N     P=0.331N     P=0.060N     P=0.164N     | 
|COCH-ARM / FISHERS |     P=0.113      P=0.247      P=0.059      P=0.121     |P=0.086N     P=0.339N     P=0.059N     P=0.181N     | 
|ORDER RESTRICTED   |     P=0.061      (e)          (e)          (e)         |P=0.033N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    5/50 (10%)   3/50 (6%)   |6/50 (12%)   4/50 (8%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/46.83      2/46.01      5/44.84      3/44.01     |6/43.48      4/44.04      0/44.22      2/45.13      | 
|POLY-3 PERCENT (g) |     2.1%         4.4%         11.2%        6.8%        |13.8%        9.1%         0.0%         4.4%         | 
|TERMINAL (d)       |     1/39 (3%)    2/40 (5%)    5/38 (13%)   1/36 (3%)   |3/33 (9%)    2/33 (6%)    0/39 (0%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      642         |603          653          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.183      P=0.509      P=0.097      P=0.282     |P=0.038N*    P=0.379N     P=0.014N*    P=0.100N     | 
|POLY 3             |     P=0.185      P=0.494      P=0.092      P=0.283     |P=0.049N*    P=0.361N     P=0.014N*    P=0.121N     | 
|POLY 1.5           |     P=0.189      P=0.493      P=0.092      P=0.286     |P=0.050N     P=0.359N     P=0.015N*    P=0.124N     | 
|POLY 6             |     P=0.182      P=0.495      P=0.091      P=0.282     |P=0.047N*    P=0.372N     P=0.014N*    P=0.118N     | 
|LOGISTIC REGRESSION|     P=0.189      P=0.509      P=0.097      P=0.300     |P=0.050N     P=0.360N     P=0.017N*    P=0.124N     | 
|COCH-ARM / FISHERS |     P=0.216      P=0.500      P=0.102      P=0.309     |P=0.054N     P=0.370N     P=0.013N*    P=0.134N     | 
|ORDER RESTRICTED   |     P=0.131      (e)          (e)          (e)         |P=0.019N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 21      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/46.92      0/46.01      0/44.84      0/43.48     |3/43.38      1/43.91      2/45.26      2/45.95      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         0.0%        |6.9%         2.3%         4.4%         4.4%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |2/33 (6%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     706          ---          ---          ---         |488          653          560          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.318N     P=0.505N     P=0.510N     P=0.520N    |P=0.469N     P=0.304N     P=0.462N     P=0.456N     | 
|POLY 3             |     P=0.299N     P=0.504N     P=0.509N     P=0.515N    |P=0.481N     P=0.301N     P=0.481N     P=0.474N     | 
|POLY 1.5           |     P=0.300N     P=0.504N     P=0.509N     P=0.512N    |P=0.489N     P=0.300N     P=0.491N     P=0.483N     | 
|POLY 6             |     P=0.297N     P=0.504N     P=0.510N     P=0.518N    |P=0.468N     P=0.305N     P=0.469N     P=0.462N     | 
|LOGISTIC REGRESSION|     P=0.310N     P=0.501N     P=0.504N     P=0.509N    |P=0.524N     P=0.312N     P=0.500N     P=0.530N     | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.500N     P=0.309N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.135N     (e)          (e)          (e)         |P=0.370N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    2/50 (4%)    3/50 (6%)   |10/50 (20%)  9/50 (18%)   7/50 (14%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     2/47.05      2/46.01      2/44.84      3/43.48     |10/44.78     9/45.50      7/44.39      7/45.17      | 
|POLY-3 PERCENT (g) |     4.3%         4.4%         4.5%         6.9%        |22.3%        19.8%        15.8%        15.5%        | 
|TERMINAL (d)       |     1/39 (3%)    2/40 (5%)    2/38 (5%)    3/36 (8%)   |6/33 (18%)   4/33 (12%)   6/39 (15%)   6/40 (15%)   | 
|FIRST INCIDENCE    |     672          729 (T)      729 (T)      729 (T)     |365          568          687          718          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.345      P=0.690N     P=0.680      P=0.460     |P=0.141N     P=0.494N     P=0.213N     P=0.195N     | 
|POLY 3             |     P=0.353      P=0.686      P=0.676      P=0.464     |P=0.226N     P=0.485N     P=0.302N     P=0.289N     | 
|POLY 1.5           |     P=0.360      P=0.686      P=0.678      P=0.471     |P=0.227N     P=0.487N     P=0.305N     P=0.290N     | 
|POLY 6             |     P=0.345      P=0.686      P=0.675      P=0.456     |P=0.223N     P=0.487N     P=0.298N     P=0.286N     | 
|LOGISTIC REGRESSION|     P=0.346      P=0.690      P=0.682      P=0.465     |P=0.223N     P=0.512N     P=0.295N     P=0.294N     | 
|COCH-ARM / FISHERS |     P=0.387      P=0.691N     P=0.691N     P=0.500     |P=0.229N     P=0.500N     P=0.298N     P=0.298N     | 
|ORDER RESTRICTED   |     P=0.447      (e)          (e)          (e)         |P=0.320N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 22      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  31/50 (62%)  33/50 (66%)  31/50 (62%) |35/50 (70%)  38/50 (76%)  28/50 (56%)  31/50 (62%)  | 
|POLY-3 RATE (b)    |     29/47.66     31/46.93     33/46.17     31/45.79    |35/44.73     38/46.31     28/45.66     31/46.05     | 
|POLY-3 PERCENT (g) |     60.9%        66.1%        71.5%        67.7%       |78.3%        82.1%        61.3%        67.3%        | 
|TERMINAL (d)       |     25/39 (64%)  28/40 (70%)  28/38 (74%)  26/36 (72%) |29/33 (88%)  30/33 (91%)  26/39 (67%)  28/40 (70%)  | 
|FIRST INCIDENCE    |     598          603          493          474         |521          540          67           582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.183      P=0.470      P=0.221      P=0.247     |P=0.004N**   P=0.334      P=0.010N*    P=0.030N*    | 
|POLY 3             |     P=0.269      P=0.376      P=0.188      P=0.315     |P=0.057N     P=0.419      P=0.055N     P=0.166N     | 
|POLY 1.5           |     P=0.276      P=0.373      P=0.189      P=0.320     |P=0.069N     P=0.399      P=0.066N     P=0.187N     | 
|POLY 6             |     P=0.254      P=0.384      P=0.187      P=0.304     |P=0.046N*    P=0.399      P=0.051N     P=0.151N     | 
|LOGISTIC REGRESSION|     P=0.213      P=0.377      P=0.175      P=0.268     |P=0.052N     P=0.410      P=0.073N     P=0.128N     | 
|COCH-ARM / FISHERS |     P=0.384      P=0.419      P=0.268      P=0.419     |P=0.113N     P=0.326      P=0.107N     P=0.263N     | 
|ORDER RESTRICTED   |     P=0.288      (e)          (e)          (e)         |P=0.055N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  21/50 (42%)  22/50 (44%)  24/50 (48%) |26/50 (52%)  20/50 (40%)  26/50 (52%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     27/50.00     21/48.49     22/47.25     24/48.00    |26/47.16     20/47.34     26/47.50     18/46.79     | 
|POLY-3 PERCENT (g) |     54.0%        43.3%        46.6%        50.0%       |55.1%        42.3%        54.7%        38.5%        | 
|TERMINAL (d)       |     16/39 (41%)  14/40 (35%)  14/38 (37%)  12/36 (33%) |13/33 (39%)  10/33 (30%)  18/39 (46%)  13/40 (33%)  | 
|FIRST INCIDENCE    |     515          435          496          474         |365          555          417          551          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.491      P=0.195N     P=0.305N     P=0.511N    |P=0.053N     P=0.206N     P=0.372N     P=0.043N*    | 
|POLY 3             |     P=0.473N     P=0.196N     P=0.299N     P=0.424N    |P=0.116N     P=0.146N     P=0.566N     P=0.077N     | 
|POLY 1.5           |     P=0.474N     P=0.189N     P=0.288N     P=0.423N    |P=0.112N     P=0.145N     P=0.581      P=0.074N     | 
|POLY 6             |     P=0.470N     P=0.204N     P=0.309N     P=0.424N    |P=0.120N     P=0.156N     P=0.555N     P=0.083N     | 
|LOGISTIC REGRESSION|     P=0.391N     P=0.137N     P=0.206N     P=0.292N    |P=0.112N     P=0.161N     P=0.575N     P=0.076N     | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.158N     P=0.212N     P=0.345N    |P=0.115N     P=0.158N     P=0.579N     P=0.079N     | 
|ORDER RESTRICTED   |     P=0.368N     (e)          (e)          (e)         |P=0.078N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 23      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                 DIISOPROPYLCARBODIIMIDE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     42/50 (84%)  42/50 (84%)  42/50 (84%)  41/50 (82%) |47/50 (94%)  43/50 (86%)  41/50 (82%)  41/50 (82%)  | 
|POLY-3 RATE (b)    |     42/50.00     42/48.92     42/48.00     41/48.00    |47/48.07     43/48.20     41/48.50     41/47.28     | 
|POLY-3 PERCENT (g) |     84.0%        85.9%        87.5%        85.4%       |97.8%        89.2%        84.5%        86.7%        | 
|TERMINAL (d)       |     31/39 (80%)  34/40 (85%)  32/38 (84%)  29/36 (81%) |32/33 (97%)  30/33 (91%)  32/39 (82%)  35/40 (88%)  | 
|FIRST INCIDENCE    |     515          435          493          474         |365          540          67           551          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.326      P=0.524N     P=0.476      P=0.403     |P=0.007N**   P=0.289N     P=0.026N*    P=0.009N**   | 
|POLY 3             |     P=0.478      P=0.510      P=0.419      P=0.534     |P=0.058N     P=0.088N     P=0.023N*    P=0.041N*    | 
|POLY 1.5           |     P=0.480      P=0.515      P=0.423      P=0.536     |P=0.049N*    P=0.089N     P=0.025N*    P=0.033N*    | 
|POLY 6             |     P=0.481      P=0.503      P=0.419      P=0.534     |P=0.072N     P=0.109N     P=0.025N*    P=0.061N     | 
|LOGISTIC REGRESSION|     P=0.507      P=0.576      P=0.489      P=0.594     |P=0.034N*    P=0.076N     P=0.053N     P=0.014N*    | 
|COCH-ARM / FISHERS |     P=0.436N     P=0.607N     P=0.607N     P=0.500N    |P=0.065N     P=0.159N     P=0.061N     P=0.061N     | 
|ORDER RESTRICTED   |     P=0.572      (e)          (e)          (e)         |P=0.030N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).