Share This:
https://ntp.niehs.nih.gov/go/19242

TDMS Study 93020-08 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                             DIISOPROPYLCARBODIIMIDE                                DATE: 07/19/04       
EXPERIMENT: 93020 TEST: 08                                                                                     TIME: 09:18:54       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05451                              ROUTE: SKIN APPLICATION                                        NTP C#: 93020D       
PATHOLOGIST: FARNELL, DANIEL                                                                                   CAS: 693-13-0        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                             DIISOPROPYLCARBODIIMIDE                                DATE: 07/19/04       
EXPERIMENT: 93020 TEST: 08                                                                                     TIME: 09:18:54       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05451                              ROUTE: SKIN APPLICATION                                        NTP C#: 93020D       
PATHOLOGIST: FARNELL, DANIEL                                                                                   CAS: 693-13-0        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                DIISOPROPYLCARBODIIMIDE                                                                           
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Kidney                                 Cyst                                                                                         
                                       Inflammation                                                                                 
                                       Metaplasia Focal Osseous                                                                     
                                       Nephropathy                                                                                  
Liver: Hepatocyte                      Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
Pancreas: Acinus                       Atrophy Focal                                                                                
Preputial Gland                        Cyst                                                                                         
Skin: Site of Application - Dermis     Inflammation Focal                                                                           
Skin: Site of Application - Epidermis  Hyperplasia                                                                                  
Skin: Subcutaneous Tissue              Edema                                                                                        
Stomach, Glandular                     Erosion                                                                                      
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Bone Marrow                            Hyperplasia                                                                                  
Heart                                  Thrombosis                                                                                   
Kidney                                 Metaplasia Focal Osseous                                                                     
Liver                                  Eosinophilic Focus                                                                           
                                       Infiltration Cellular Mixed Cell                                                             
Liver: Hepatocyte                      Mixed Cell Focus                                                                             
Lymph Node, Mandibular                 Hyperplasia Lymphoid                                                                         
Lymph Node: Iliac                      Ectasia                                                                                      
                                       Hemorrhage                                                                                   
Ovary                                  Hemorrhage                                                                                   
Spleen                                 Hematopoietic Cell Proliferation                                                             
Thymus                                 Hyperplasia Lymphoid                                                                         
Thyroid Gland: Follicular Cell         Hyperplasia Focal                                                                            
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    2/50 (4%)    2/49 (4%)   |2/50 (4%)    1/50 (2%)    1/49 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     3/46.83      2/46.60      2/44.84      2/42.72     |2/42.68      1/44.63      1/43.22      3/45.70      | 
|POLY-3 PERCENT (g) |     6.4%         4.3%         4.5%         4.7%        |4.7%         2.2%         2.3%         6.6%         | 
|TERMINAL (d)       |     3/39 (8%)    1/40 (3%)    2/38 (5%)    2/36 (6%)   |2/33 (6%)    0/33 (0%)    1/38 (3%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      545          729 (T)      729 (T)     |729 (T)      12           729 (T)      551          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.472N     P=0.491N     P=0.512N     P=0.537N    |P=0.386      P=0.500N     P=0.451N     P=0.575      | 
|POLY 3             |     P=0.469N     P=0.502N     P=0.520N     P=0.542N    |P=0.340      P=0.484N     P=0.496N     P=0.531      | 
|POLY 1.5           |     P=0.464N     P=0.505N     P=0.519N     P=0.536N    |P=0.332      P=0.485N     P=0.502N     P=0.521      | 
|POLY 6             |     P=0.474N     P=0.498N     P=0.520N     P=0.546N    |P=0.351      P=0.488N     P=0.489N     P=0.543      | 
|LOGISTIC REGRESSION|     P=0.461N     P=0.489N     P=0.512N     P=0.537N    |P=0.296      P=0.536N     P=0.451N     P=0.508      | 
|COCH-ARM / FISHERS |     P=0.440N     P=0.500N     P=0.500N     P=0.510N    |P=0.324      P=0.500N     P=0.508N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.533N     (e)          (e)          (e)         |P=0.318      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Cytoplasmic Alteration Focal                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   5/50 (10%)   7/50 (14%)   4/49 (8%)   |1/50 (2%)    2/50 (4%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     9/46.83      5/46.01      7/44.84      4/42.72     |1/42.68      2/43.63      1/43.38      0/45.13      | 
|POLY-3 PERCENT (g) |     19.2%        10.9%        15.6%        9.4%        |2.3%         4.6%         2.3%         0.0%         | 
|TERMINAL (d)       |     9/39 (23%)   5/40 (13%)   7/38 (18%)   4/36 (11%)  |1/33 (3%)    2/33 (6%)    0/38 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      690          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.167N     P=0.176N     P=0.413N     P=0.146N    |P=0.208N     P=0.500      P=0.736N     P=0.462N     | 
|POLY 3             |     P=0.169N     P=0.202N     P=0.429N     P=0.153N    |P=0.235N     P=0.508      P=0.757N     P=0.489N     | 
|POLY 1.5           |     P=0.164N     P=0.204N     P=0.428N     P=0.149N    |P=0.240N     P=0.507      P=0.760      P=0.492N     | 
|POLY 6             |     P=0.174N     P=0.200N     P=0.430N     P=0.157N    |P=0.229N     P=0.503      P=0.752N     P=0.485N     | 
|LOGISTIC REGRESSION|     P=0.167N     P=0.176N     P=0.413N     P=0.146N    |P=0.230N     P=0.500      P=0.761N     (e)          | 
|COCH-ARM / FISHERS |     P=0.139N     P=0.194N     P=0.393N     P=0.125N    |P=0.248N     P=0.500      P=0.747      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.139N     (e)          (e)          (e)         |P=0.218N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Hyperostosis                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/46.92      2/46.01      1/44.84      0/43.48     |3/43.07      1/43.63      1/44.38      2/45.13      | 
|POLY-3 PERCENT (g) |     4.3%         4.4%         2.2%         0.0%        |7.0%         2.3%         2.3%         4.4%         | 
|TERMINAL (d)       |     1/39 (3%)    2/40 (5%)    1/38 (3%)    0/36 (0%)   |2/33 (6%)    1/33 (3%)    0/39 (0%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     706          729 (T)      729 (T)      ---         |619          729 (T)      690          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.141N     P=0.689N     P=0.512N     P=0.260N    |P=0.407N     P=0.304N     P=0.272N     P=0.428N     | 
|POLY 3             |     P=0.138N     P=0.687      P=0.516N     P=0.255N    |P=0.464N     P=0.300N     P=0.294N     P=0.479N     | 
|POLY 1.5           |     P=0.136N     P=0.686      P=0.515N     P=0.251N    |P=0.469N     P=0.299N     P=0.300N     P=0.485N     | 
|POLY 6             |     P=0.141N     P=0.687      P=0.517N     P=0.258N    |P=0.456N     P=0.307N     P=0.289N     P=0.473N     | 
|LOGISTIC REGRESSION|     P=0.140N     P=0.690      P=0.515N     P=0.254N    |P=0.457N     P=0.299N     P=0.302N     P=0.481N     | 
|COCH-ARM / FISHERS |     P=0.125N     P=0.691N     P=0.500N     P=0.247N    |P=0.474N     P=0.309N     P=0.309N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.166N     (e)          (e)          (e)         |P=0.273N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/49 (18%)   13/50 (26%)  12/50 (24%)  7/50 (14%)  |14/49 (29%)  5/50 (10%)   10/50 (20%)  2/49 (4%)    | 
|POLY-3 RATE (b)    |     9/46.49      13/46.24     12/45.27     7/44.68     |14/44.39     5/44.15      10/45.05     2/44.17      | 
|POLY-3 PERCENT (g) |     19.4%        28.1%        26.5%        15.7%       |31.5%        11.3%        22.2%        4.5%         | 
|TERMINAL (d)       |     7/39 (18%)   12/40 (30%)  10/38 (26%)  3/36 (8%)   |8/33 (24%)   3/33 (9%)    8/39 (21%)   2/40 (5%)    | 
|FIRST INCIDENCE    |     682          670          653          558         |488          625          560          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.337N     P=0.253      P=0.288      P=0.470N    |P=0.002N**   P=0.027N*    P=0.161N     P<0.001N**   | 
|POLY 3             |     P=0.290N     P=0.228      P=0.286      P=0.426N    |P=0.003N**   P=0.018N*    P=0.224N     P<0.001N**   | 
|POLY 1.5           |     P=0.284N     P=0.230      P=0.290      P=0.420N    |P=0.003N**   P=0.016N*    P=0.226N     P<0.001N**   | 
|POLY 6             |     P=0.293N     P=0.225      P=0.283      P=0.429N    |P=0.002N**   P=0.021N*    P=0.225N     P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.294N     P=0.225      P=0.279      P=0.407N    |P=0.003N**   P=0.018N*    P=0.219N     P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.234N     P=0.251      P=0.331      P=0.376N    |P=0.004N**   P=0.017N*    P=0.224N     P<0.001N**   | 
|ORDER RESTRICTED   |     P=0.241N     (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.28      0/46.01      0/44.84      0/43.48     |2/43.44      2/44.39      0/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.6%         4.5%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |521          540          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.267N     P=0.680N     P=0.226N     P=0.456N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.291N     P=0.686N     P=0.233N     P=0.487N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.293N     P=0.686N     P=0.236N     P=0.490N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.288N     P=0.691N     P=0.231N     P=0.483N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.307N     P=0.680      P=0.236N     P=0.516N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.296N     P=0.691N     P=0.247N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.257N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.28      0/46.01      0/44.84      0/43.48     |1/42.68      2/44.91      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |1/33 (3%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      12           ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.177N     P=0.500      P=0.467N     P=0.462N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.179N     P=0.518      P=0.493N     P=0.489N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.182N     P=0.516      P=0.497N     P=0.492N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.177N     P=0.516      P=0.489N     P=0.485N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.201N     P=0.459      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.188N     P=0.500      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.167N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/46 (2%)    0/46 (0%)    0/47 (0%)    0/44 (0%)   |1/47 (2%)    0/48 (0%)    2/49 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/44.17      0/42.61      0/42.82      0/40.40     |1/41.09      0/41.91      2/44.11      0/44.17      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |2.4%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/32 (0%)    1/39 (3%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     725          ---          ---          ---         |603          ---          614          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.319N     P=0.500N     P=0.510N     P=0.521N    |P=0.437N     P=0.500N     P=0.522      P=0.496N     | 
|POLY 3             |     P=0.305N     P=0.507N     P=0.506N     P=0.518N    |P=0.440N     P=0.496N     P=0.525      P=0.486N     | 
|POLY 1.5           |     P=0.306N     P=0.506N     P=0.505N     P=0.516N    |P=0.444N     P=0.494N     P=0.519      P=0.487N     | 
|POLY 6             |     P=0.304N     P=0.508N     P=0.508N     P=0.520N    |P=0.434N     P=0.502N     P=0.530      P=0.485N     | 
|LOGISTIC REGRESSION|     P=0.317N     P=0.508N     P=0.508N     P=0.521N    |P=0.458N     P=0.503N     P=0.514      P=0.510N     | 
|COCH-ARM / FISHERS |     P=0.309N     P=0.500N     P=0.495N     P=0.511N    |P=0.451N     P=0.495N     P=0.516      P=0.490N     | 
|ORDER RESTRICTED   |     P=0.137N     (e)          (e)          (e)         |P=0.312N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/46 (4%)    3/46 (7%)    1/47 (2%)    3/44 (7%)   |0/47 (0%)    1/48 (2%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/44.16      3/42.61      1/42.97      3/40.40     |0/40.66      1/41.91      0/43.71      0/44.17      | 
|POLY-3 PERCENT (g) |     4.5%         7.0%         2.3%         7.4%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    3/40 (8%)    0/38 (0%)    3/36 (8%)   |0/33 (0%)    1/32 (3%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      690          729 (T)     |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.434      P=0.512      P=0.512N     P=0.463     |P=0.533N     P=0.494      (e)          (e)          | 
|POLY 3             |     P=0.439      P=0.484      P=0.509N     P=0.460     |P=0.557N     P=0.506      (e)          (e)          | 
|POLY 1.5           |     P=0.443      P=0.486      P=0.508N     P=0.464     |P=0.558N     P=0.507      (e)          (e)          | 
|POLY 6             |     P=0.434      P=0.482      P=0.511N     P=0.454     |P=0.558N     P=0.502      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.433      P=0.512      P=0.506N     P=0.463     |(e)          P=0.494      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.457      P=0.500      P=0.492N     P=0.479     |P=0.561N     P=0.505      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.441      (e)          (e)          (e)         |P=0.372N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder                                                                                                                      | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/45 (2%)    1/42 (2%)    2/43 (5%)    0/41 (0%)   |0/42 (0%)    1/47 (2%)    0/42 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     1/43.81      1/40.34      2/41.14      0/38.54     |0/36.97      1/41.56      0/39.63      0/42.83      | 
|POLY-3 PERCENT (g) |     2.3%         2.5%         4.9%         0.0%        |0.0%         2.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    1/39 (3%)    1/37 (3%)    0/36 (0%)   |0/31 (0%)    1/33 (3%)    0/37 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      496          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.392N     P=0.762      P=0.481      P=0.516N    |P=0.528N     P=0.512      (e)          (e)          | 
|POLY 3             |     P=0.400N     P=0.742      P=0.478      P=0.526N    |P=0.550N     P=0.523      (e)          (e)          | 
|POLY 1.5           |     P=0.398N     P=0.741      P=0.478      P=0.525N    |P=0.552N     P=0.523      (e)          (e)          | 
|POLY 6             |     P=0.402N     P=0.743      P=0.478      P=0.527N    |P=0.550N     P=0.521      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.365N     P=0.762      P=0.550      (e)         |(e)          P=0.512      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.388N     P=0.735      P=0.483      P=0.523N    |P=0.556N     P=0.528      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.280N     (e)          (e)          (e)         |P=0.378N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    2/49 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.83      0/46.01      0/44.84      1/43.48     |0/42.68      2/43.06      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         2.3%        |0.0%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    0/40 (0%)    0/38 (0%)    1/36 (3%)   |0/33 (0%)    1/33 (3%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |---          690          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.577      P=0.495N     P=0.505N     P=0.744     |P=0.372N     P=0.237      (e)          (e)          | 
|POLY 3             |     P=0.585      P=0.504N     P=0.509N     P=0.744     |P=0.388N     P=0.239      (e)          (e)          | 
|POLY 1.5           |     P=0.587      P=0.504N     P=0.508N     P=0.747     |P=0.393N     P=0.238      (e)          (e)          | 
|POLY 6             |     P=0.582      P=0.503N     P=0.509N     P=0.741     |P=0.385N     P=0.237      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.577      (e)          (e)          P=0.744     |P=0.395N     P=0.238      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.595      P=0.500N     P=0.500N     P=0.753N    |P=0.404N     P=0.242      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.380      (e)          (e)          (e)         |P=0.238N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland: Epithelium                                                                                                      | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    1/49 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/46.83      0/46.01      3/45.53      1/43.48     |1/42.68      1/42.91      1/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     6.4%         0.0%         6.6%         2.3%        |2.3%         2.3%         2.3%         0.0%         | 
|TERMINAL (d)       |     3/39 (8%)    0/40 (0%)    2/38 (5%)    1/36 (3%)   |1/33 (3%)    1/33 (3%)    1/39 (3%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          493          729 (T)     |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.406N     P=0.117N     P=0.649      P=0.334N    |P=0.266N     P=0.762      P=0.724N     P=0.462N     | 
|POLY 3             |     P=0.396N     P=0.122N     P=0.649      P=0.332N    |P=0.300N     P=0.760N     P=0.753N     P=0.489N     | 
|POLY 1.5           |     P=0.391N     P=0.122N     P=0.647      P=0.328N    |P=0.304N     P=0.760N     P=0.757N     P=0.492N     | 
|POLY 6             |     P=0.401N     P=0.121N     P=0.652      P=0.337N    |P=0.295N     P=0.760      P=0.749N     P=0.485N     | 
|LOGISTIC REGRESSION|     P=0.376N     (e)          P=0.657N     P=0.334N    |P=0.266N     P=0.762      P=0.724N     (e)          | 
|COCH-ARM / FISHERS |     P=0.373N     P=0.121N     P=0.661N     P=0.309N    |P=0.310N     P=0.747      P=0.753N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.248N     (e)          (e)          (e)         |P=0.317N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    3/50 (6%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      1/45.02      1/44.19     |0/42.68      3/43.91      1/43.71      1/45.56      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         2.3%        |0.0%         6.8%         2.3%         2.2%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    2/33 (6%)    0/38 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          681          484         |---          653          584          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.219      (e)          P=0.491      P=0.488     |P=0.613N     P=0.123      P=0.504      P=0.514      | 
|POLY 3             |     P=0.222      (e)          P=0.492      P=0.488     |P=0.623N     P=0.124      P=0.505      P=0.513      | 
|POLY 1.5           |     P=0.224      (e)          P=0.492      P=0.490     |P=0.613      P=0.123      P=0.500      P=0.509      | 
|POLY 6             |     P=0.220      (e)          P=0.493      P=0.487     |P=0.614N     P=0.122      P=0.510      P=0.518      | 
|LOGISTIC REGRESSION|     P=0.277      (e)          P=0.508      P=0.652     |P=0.583      P=0.123      P=0.499      P=0.480      | 
|COCH-ARM / FISHERS |     P=0.236      (e)          P=0.500      P=0.500     |P=0.590      P=0.121      P=0.495      P=0.500      | 
|ORDER RESTRICTED   |     P=0.240      (e)          (e)          (e)         |P=0.227      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |4/50 (8%)    0/50 (0%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.83      1/46.01      0/44.84      0/43.48     |4/44.10      0/43.63      2/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |9.1%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    1/40 (3%)    0/38 (0%)    0/36 (0%)   |1/33 (3%)    0/33 (0%)    1/38 (3%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |44           ---          67           ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.582N     P=0.505      (e)          (e)         |P=0.054N     P=0.068N     P=0.312N     P=0.055N     | 
|POLY 3             |     P=0.575N     P=0.496      (e)          (e)         |P=0.057N     P=0.061N     P=0.336N     P=0.057N     | 
|POLY 1.5           |     P=0.574N     P=0.496      (e)          (e)         |P=0.059N     P=0.061N     P=0.342N     P=0.059N     | 
|POLY 6             |     P=0.575N     P=0.497      (e)          (e)         |P=0.054N     P=0.064N     P=0.330N     P=0.056N     | 
|LOGISTIC REGRESSION|     (e)          P=0.505      (e)          (e)         |P=0.066N     P=0.067N     P=0.311N     P=0.078N     | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.062N     P=0.059N     P=0.349N     P=0.059N     | 
|ORDER RESTRICTED   |     P=0.391N     (e)          (e)          (e)         |P=0.011N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    2/50 (4%)    2/49 (4%)    1/50 (2%)   |0/50 (0%)    2/49 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.28      2/46.01      2/44.29      1/43.48     |0/42.68      2/42.80      1/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     4.3%         4.4%         4.5%         2.3%        |0.0%         4.7%         2.3%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    2/40 (5%)    2/38 (5%)    1/36 (3%)   |0/33 (0%)    2/33 (6%)    1/39 (3%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.407N     P=0.686N     P=0.686      P=0.528N    |P=0.406N     P=0.238      P=0.533      (e)          | 
|POLY 3             |     P=0.398N     P=0.692      P=0.678      P=0.522N    |P=0.438N     P=0.238      P=0.507      (e)          | 
|POLY 1.5           |     P=0.392N     P=0.692      P=0.678      P=0.516N    |P=0.445N     P=0.237      P=0.503      (e)          | 
|POLY 6             |     P=0.405N     P=0.691      P=0.678      P=0.528N    |P=0.432N     P=0.235      P=0.511      (e)          | 
|LOGISTIC REGRESSION|     P=0.407N     P=0.686N     P=0.686      P=0.528N    |(e)          P=0.238      P=0.533      (e)          | 
|COCH-ARM / FISHERS |     P=0.367N     P=0.684N     P=0.691N     P=0.492N    |P=0.459N     P=0.242      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.483N     (e)          (e)          (e)         |P=0.315N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/48 (6%)    10/48 (21%)  5/50 (10%)   3/48 (6%)   |1/49 (2%)    0/49 (0%)    4/50 (8%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     3/45.74      10/44.38     5/44.90      3/41.93     |1/41.96      0/42.91      4/44.51      0/44.17      | 
|POLY-3 PERCENT (g) |     6.6%         22.5%        11.1%        7.2%        |2.4%         0.0%         9.0%         0.0%         | 
|TERMINAL (d)       |     3/39 (8%)    10/40 (25%)  4/38 (11%)   3/36 (8%)   |1/33 (3%)    0/33 (0%)    3/39 (8%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      715          729 (T)     |729 (T)      ---          653          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.336N     P=0.039 *    P=0.341      P=0.626     |P=0.469N     P=0.500N     P=0.227      P=0.462N     | 
|POLY 3             |     P=0.341N     P=0.029 *    P=0.346      P=0.622     |P=0.507N     P=0.496N     P=0.197      P=0.490N     | 
|POLY 1.5           |     P=0.327N     P=0.030 *    P=0.351      P=0.630     |P=0.515N     P=0.496N     P=0.191      P=0.493N     | 
|POLY 6             |     P=0.355N     P=0.029 *    P=0.341      P=0.614     |P=0.495N     P=0.498N     P=0.203      P=0.487N     | 
|LOGISTIC REGRESSION|     P=0.347N     P=0.039 *    P=0.329      P=0.626     |P=0.512N     (e)          P=0.195      (e)          | 
|COCH-ARM / FISHERS |     P=0.275N     P=0.035 *    P=0.381      P=0.661N    |P=0.530N     P=0.500N     P=0.187      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.230N     (e)          (e)          (e)         |P=0.219N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hydronephrosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    1/48 (2%)    0/50 (0%)    0/48 (0%)   |0/49 (0%)    0/49 (0%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/45.74      1/44.38      0/44.84      0/41.93     |0/41.96      0/42.91      1/44.22      1/44.56      | 
|POLY-3 PERCENT (g) |     4.4%         2.3%         0.0%         0.0%        |0.0%         0.0%         2.3%         2.2%         | 
|TERMINAL (d)       |     2/39 (5%)    1/40 (3%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    1/39 (3%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          ---          729 (T)      619          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.109N     P=0.491N     P=0.244N     P=0.256N    |P=0.257      (e)          P=0.533      P=0.505      | 
|POLY 3             |     P=0.102N     P=0.511N     P=0.242N     P=0.257N    |P=0.252      (e)          P=0.510      P=0.512      | 
|POLY 1.5           |     P=0.101N     P=0.509N     P=0.240N     P=0.253N    |P=0.246      (e)          P=0.507      P=0.508      | 
|POLY 6             |     P=0.103N     P=0.511N     P=0.244N     P=0.261N    |P=0.260      (e)          P=0.514      P=0.516      | 
|LOGISTIC REGRESSION|     P=0.109N     P=0.491N     (e)          (e)         |P=0.234      (e)          P=0.533      P=0.484      | 
|COCH-ARM / FISHERS |     P=0.099N     P=0.500N     P=0.237N     P=0.247N    |P=0.235      (e)          P=0.505      P=0.500      | 
|ORDER RESTRICTED   |     P=0.087N     (e)          (e)          (e)         |P=0.261      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    0/50 (0%)    0/48 (0%)   |2/49 (4%)    2/49 (4%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/45.74      0/44.38      0/44.84      0/41.93     |2/42.08      2/42.91      1/44.22      1/44.17      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.8%         4.7%         2.3%         2.3%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |1/33 (3%)    2/33 (6%)    1/39 (3%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |698          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.273N     P=0.688      P=0.452N     P=0.441N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.324N     P=0.687N     P=0.483N     P=0.483N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.329N     P=0.687N     P=0.488N     P=0.488N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.319N     P=0.693N     P=0.478N     P=0.479N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.305N     P=0.695      P=0.478N     P=0.478N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.336N     P=0.691N     P=0.492N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.420N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    3/48 (6%)    1/50 (2%)    1/48 (2%)   |3/49 (6%)    2/49 (4%)    1/50 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     2/45.74      3/44.38      1/44.84      1/41.93     |3/41.96      2/42.91      1/44.22      1/44.17      | 
|POLY-3 PERCENT (g) |     4.4%         6.8%         2.2%         2.4%        |7.2%         4.7%         2.3%         2.3%         | 
|TERMINAL (d)       |     2/39 (5%)    3/40 (8%)    1/38 (3%)    1/36 (3%)   |3/33 (9%)    2/33 (6%)    1/39 (3%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.308N     P=0.512      P=0.509N     P=0.528N    |P=0.145N     P=0.500N     P=0.247N     P=0.239N     | 
|POLY 3             |     P=0.305N     P=0.486      P=0.507N     P=0.530N    |P=0.189N     P=0.490N     P=0.286N     P=0.287N     | 
|POLY 1.5           |     P=0.299N     P=0.488      P=0.504N     P=0.524N    |P=0.193N     P=0.490N     P=0.292N     P=0.292N     | 
|POLY 6             |     P=0.310N     P=0.485      P=0.511N     P=0.536N    |P=0.184N     P=0.496N     P=0.281N     P=0.281N     | 
|LOGISTIC REGRESSION|     P=0.308N     P=0.512      P=0.509N     P=0.528N    |P=0.145N     P=0.500N     P=0.247N     P=0.239N     | 
|COCH-ARM / FISHERS |     P=0.276N     P=0.500      P=0.485N     P=0.500N    |P=0.198N     P=0.500N     P=0.301N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.352N     (e)          (e)          (e)         |P=0.198N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    0/50 (0%)    3/48 (6%)   |1/49 (2%)    1/49 (2%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/45.74      0/44.38      0/44.84      3/43.00     |1/42.35      1/42.91      0/44.22      0/44.17      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         7.0%        |2.4%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    1/36 (3%)   |0/33 (0%)    1/33 (3%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          558         |619          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010 *    (e)          (e)          P=0.112     |P=0.219N     P=0.758N     P=0.500N     P=0.495N     | 
|POLY 3             |     P=0.010 *    (e)          (e)          P=0.108     |P=0.233N     P=0.758N     P=0.491N     P=0.492N     | 
|POLY 1.5           |     P=0.010 *    (e)          (e)          P=0.109     |P=0.234N     P=0.757N     P=0.494N     P=0.494N     | 
|POLY 6             |     P=0.010 *    (e)          (e)          P=0.107     |P=0.232N     P=0.759      P=0.490N     P=0.490N     | 
|LOGISTIC REGRESSION|     P=0.014 *    (e)          (e)          P=0.151     |P=0.235N     P=0.762      P=0.496N     P=0.516N     | 
|COCH-ARM / FISHERS |     P=0.012 *    (e)          (e)          P=0.121     |P=0.235N     P=0.753N     P=0.495N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.006 **   (e)          (e)          (e)         |P=0.242N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Focal Osseous                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/48 (8%)    2/48 (4%)    1/50 (2%)    0/48 (0%)   |5/49 (10%)   2/49 (4%)    0/50 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/45.74      2/44.53      1/44.90      0/41.93     |5/42.40      2/42.91      0/44.22      1/44.17      | 
|POLY-3 PERCENT (g) |     8.8%         4.5%         2.2%         0.0%        |11.8%        4.7%         0.0%         2.3%         | 
|TERMINAL (d)       |     4/39 (10%)   1/40 (3%)    0/38 (0%)    0/36 (0%)   |3/33 (9%)    2/33 (6%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      691          715          ---         |619          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.037N*    P=0.330N     P=0.191N     P=0.073N    |P=0.030N*    P=0.222N     P=0.026N*    P=0.075N     | 
|POLY 3             |     P=0.032N*    P=0.350N     P=0.184N     P=0.072N    |P=0.040N*    P=0.210N     P=0.027N*    P=0.092N     | 
|POLY 1.5           |     P=0.031N*    P=0.349N     P=0.182N     P=0.070N    |P=0.041N*    P=0.209N     P=0.028N*    P=0.094N     | 
|POLY 6             |     P=0.033N*    P=0.349N     P=0.187N     P=0.074N    |P=0.038N*    P=0.218N     P=0.026N*    P=0.090N     | 
|LOGISTIC REGRESSION|     P=0.034N*    P=0.351N     P=0.192N     (e)         |P=0.038N*    P=0.209N     P=0.030N*    P=0.093N     | 
|COCH-ARM / FISHERS |     P=0.029N*    P=0.339N     P=0.168N     P=0.059N    |P=0.043N*    P=0.218N     P=0.027N*    P=0.102N     | 
|ORDER RESTRICTED   |     P=0.024N*    (e)          (e)          (e)         |P=0.011N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     46/48 (96%)  44/48 (92%)  41/50 (82%)  40/48 (83%) |13/49 (27%)  8/49 (16%)   11/50 (22%)  18/49 (37%)  | 
|POLY-3 RATE (b)    |     46/47.64     44/45.63     41/47.04     40/43.37    |13/42.72     8/43.99      11/44.22     18/44.17     | 
|POLY-3 PERCENT (g) |     96.6%        96.4%        87.2%        92.2%       |30.4%        18.2%        24.9%        40.8%        | 
|TERMINAL (d)       |     39/39 (100%) 39/40 (98%)  34/38 (90%)  34/36 (94%) |11/33 (33%)  6/33 (18%)   11/39 (28%)  18/40 (45%)  | 
|FIRST INCIDENCE    |     515          603          493          558         |521          555          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.337N     P=0.302N     P=0.263N     P=0.356N    |P=0.188      P=0.159N     P=0.244N     P=0.400      | 
|POLY 3             |     P=0.152N     P=0.721N     P=0.084N     P=0.310N    |P=0.068      P=0.138N     P=0.367N     P=0.216      | 
|POLY 1.5           |     P=0.105N     P=0.632N     P=0.079N     P=0.208N    |P=0.068      P=0.143N     P=0.378N     P=0.211      | 
|POLY 6             |     P=0.213N     P=0.729      P=0.091N     P=0.429N    |P=0.071      P=0.141N     P=0.359N     P=0.220      | 
|LOGISTIC REGRESSION|     P=0.153N     P=0.565N     P=0.088N     P=0.259N    |P=0.092      P=0.150N     P=0.336N     P=0.251      | 
|COCH-ARM / FISHERS |     P=0.028N*    P=0.339N     P=0.030N*    P=0.045N*   |P=0.068      P=0.162N     P=0.385N     P=0.193      | 
|ORDER RESTRICTED   |     P=0.119N     (e)          (e)          (e)         |P=0.062      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    0/50 (0%)    0/48 (0%)   |3/49 (6%)    1/49 (2%)    0/50 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/45.74      0/44.38      0/44.84      0/41.93     |3/43.32      1/43.30      0/44.22      2/44.99      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.9%         2.3%         0.0%         4.5%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |1/33 (3%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |488          617          ---          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.424N     P=0.295N     P=0.113N     P=0.469N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.439N     P=0.305N     P=0.115N     P=0.483N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.442N     P=0.303N     P=0.116N     P=0.488N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.434N     P=0.312N     P=0.114N     P=0.476N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.469N     P=0.324N     P=0.112N     P=0.553N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.443N     P=0.309N     P=0.117N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.174N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    3/48 (6%)    0/50 (0%)    1/48 (2%)   |0/49 (0%)    0/49 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/45.74      3/44.38      0/44.84      1/41.93     |0/41.96      0/42.91      0/44.22      0/44.17      | 
|POLY-3 PERCENT (g) |     4.4%         6.8%         0.0%         2.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    3/40 (8%)    0/38 (0%)    1/36 (3%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.266N     P=0.512      P=0.244N     P=0.528N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.258N     P=0.486      P=0.242N     P=0.530N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.255N     P=0.488      P=0.240N     P=0.524N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.262N     P=0.485      P=0.244N     P=0.536N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.266N     P=0.512      (e)          P=0.528N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.239N     P=0.500      P=0.237N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.203N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      0/44.84      0/42.71     |1/42.68      2/43.91      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |1/33 (3%)    1/33 (3%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      653          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.165N     P=0.500      P=0.467N     P=0.462N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.180N     P=0.510      P=0.493N     P=0.489N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.183N     P=0.508      P=0.497N     P=0.492N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.177N     P=0.507      P=0.489N     P=0.485N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.182N     P=0.506      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.188N     P=0.500      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.163N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    2/49 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.83      1/46.01      1/44.84      2/42.71     |0/42.68      0/43.63      0/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         2.2%         4.7%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     2/39 (5%)    1/40 (3%)    1/38 (3%)    2/36 (6%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.522      P=0.491N     P=0.509N     P=0.666     |P=0.224      (e)          (e)          P=0.538      | 
|POLY 3             |     P=0.525      P=0.506N     P=0.515N     P=0.660     |P=0.206      (e)          (e)          P=0.511      | 
|POLY 1.5           |     P=0.529      P=0.507N     P=0.515N     P=0.665     |P=0.203      (e)          (e)          P=0.508      | 
|POLY 6             |     P=0.521      P=0.505N     P=0.515N     P=0.657     |P=0.209      (e)          (e)          P=0.515      | 
|LOGISTIC REGRESSION|     P=0.522      P=0.491N     P=0.509N     P=0.666     |(e)          (e)          (e)          P=0.538      | 
|COCH-ARM / FISHERS |     P=0.548      P=0.500N     P=0.500N     P=0.684     |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.506      (e)          (e)          (e)         |P=0.131      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    4/49 (8%)   |6/50 (12%)   1/50 (2%)    6/50 (12%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/47.01      1/46.01      1/44.84      4/42.71     |6/42.72      1/43.63      6/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         2.2%         9.4%        |14.1%        2.3%         13.6%        0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    1/40 (3%)    1/38 (3%)    4/36 (11%)  |5/33 (15%)   1/33 (3%)    6/39 (15%)   0/40 (0%)    | 
|FIRST INCIDENCE    |     682          729 (T)      729 (T)      729 (T)     |720          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.137      P=0.497N     P=0.514N     P=0.297     |P=0.024N*    P=0.060N     P=0.502N     P=0.010N*    | 
|POLY 3             |     P=0.144      P=0.507N     P=0.516N     P=0.294     |P=0.035N*    P=0.052N     P=0.597N     P=0.012N*    | 
|POLY 1.5           |     P=0.147      P=0.507N     P=0.515N     P=0.300     |P=0.038N*    P=0.052N     P=0.609N     P=0.013N*    | 
|POLY 6             |     P=0.141      P=0.508N     P=0.518N     P=0.288     |P=0.031N*    P=0.053N     P=0.584N     P=0.011N*    | 
|LOGISTIC REGRESSION|     P=0.135      P=0.505N     P=0.513N     P=0.291     |P=0.025N*    P=0.060N     P=0.536N     P=0.011N*    | 
|COCH-ARM / FISHERS |     P=0.158      P=0.500N     P=0.500N     P=0.329     |P=0.045N*    P=0.056N     P=0.620N     P=0.013N*    | 
|ORDER RESTRICTED   |     P=0.106      (e)          (e)          (e)         |P=0.006N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      0/44.84      0/42.71     |0/42.68      2/44.15      0/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.5%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          625          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.569      P=0.239      (e)          P=0.538      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.561      P=0.245      (e)          P=0.511      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.554      P=0.243      (e)          P=0.508      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.568      P=0.244      (e)          P=0.515      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.539      P=0.234      (e)          P=0.538      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.539      P=0.247      (e)          P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.330      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia Focal Lymphoid                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      0/44.84      0/42.71     |0/42.68      1/43.63      2/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.3%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    1/33 (3%)    2/39 (5%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.561N     P=0.500      P=0.276      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.594N     P=0.504      P=0.245      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.602N     P=0.504      P=0.241      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.586N     P=0.502      P=0.249      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.500      P=0.276      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.616N     P=0.500      P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.322N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   5/50 (10%)   5/50 (10%)   6/49 (12%)  |16/50 (32%)  9/50 (18%)   10/50 (20%)  22/50 (44%)  | 
|POLY-3 RATE (b)    |     8/46.94      5/46.01      5/45.27      6/43.28     |16/43.97     9/46.01      10/45.06     22/45.62     | 
|POLY-3 PERCENT (g) |     17.0%        10.9%        11.0%        13.9%       |36.4%        19.6%        22.2%        48.2%        | 
|TERMINAL (d)       |     7/39 (18%)   5/40 (13%)   3/38 (8%)    4/36 (11%)  |12/33 (36%)  4/33 (12%)   8/39 (21%)   21/40 (53%)  | 
|FIRST INCIDENCE    |     702          729 (T)      653          642         |603          12           603          582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.454N     P=0.263N     P=0.300N     P=0.452N    |P=0.139      P=0.095N     P=0.069N     P=0.358      | 
|POLY 3             |     P=0.436N     P=0.289N     P=0.299N     P=0.450N    |P=0.039 *    P=0.058N     P=0.106N     P=0.176      | 
|POLY 1.5           |     P=0.432N     P=0.289N     P=0.301N     P=0.445N    |P=0.038 *    P=0.061N     P=0.115N     P=0.171      | 
|POLY 6             |     P=0.436N     P=0.287N     P=0.296N     P=0.452N    |P=0.040 *    P=0.061N     P=0.099N     P=0.177      | 
|LOGISTIC REGRESSION|     P=0.451N     P=0.282N     P=0.303N     P=0.457N    |P=0.048 *    P=0.085N     P=0.111N     P=0.205      | 
|COCH-ARM / FISHERS |     P=0.399N     P=0.277N     P=0.277N     P=0.403N    |P=0.043 *    P=0.083N     P=0.127N     P=0.151      | 
|ORDER RESTRICTED   |     P=0.377N     (e)          (e)          (e)         |P=0.013 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     19/50 (38%)  17/50 (34%)  12/50 (24%)  8/49 (16%)  |3/50 (6%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     19/46.83     17/46.01     12/44.84     8/42.71     |3/43.07      2/43.63      0/44.22      1/45.62      | 
|POLY-3 PERCENT (g) |     40.6%        37.0%        26.8%        18.7%       |7.0%         4.6%         0.0%         2.2%         | 
|TERMINAL (d)       |     19/39 (49%)  17/40 (43%)  12/38 (32%)  8/36 (22%)  |2/33 (6%)    2/33 (6%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |619          729 (T)      ---          582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008N**   P=0.372N     P=0.098N     P=0.016N*   |P=0.134N     P=0.498N     P=0.104N     P=0.269N     | 
|POLY 3             |     P=0.009N**   P=0.442N     P=0.118N     P=0.019N*   |P=0.157N     P=0.494N     P=0.114N     P=0.285N     | 
|POLY 1.5           |     P=0.009N**   P=0.445N     P=0.119N     P=0.018N*   |P=0.160N     P=0.493N     P=0.116N     P=0.291N     | 
|POLY 6             |     P=0.010N*    P=0.436N     P=0.116N     P=0.020N*   |P=0.153N     P=0.503N     P=0.111N     P=0.278N     | 
|LOGISTIC REGRESSION|     P=0.008N**   P=0.372N     P=0.098N     P=0.016N*   |P=0.162N     P=0.492N     P=0.119N     P=0.313N     | 
|COCH-ARM / FISHERS |     P=0.006N**   P=0.418N     P=0.097N     P=0.014N*   |P=0.163N     P=0.500N     P=0.121N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.016N*    (e)          (e)          (e)         |P=0.097N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/50 (0%)    4/50 (8%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.83      0/46.01      0/44.84      0/42.71     |0/42.68      0/43.63      4/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         9.0%         0.0%         | 
|TERMINAL (d)       |     2/39 (5%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    4/39 (10%)   0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.122N     P=0.233N     P=0.244N     P=0.256N    |P=0.564      (e)          P=0.086      (e)          | 
|POLY 3             |     P=0.113N     P=0.241N     P=0.247N     P=0.258N    |P=0.536      (e)          P=0.065      (e)          | 
|POLY 1.5           |     P=0.113N     P=0.242N     P=0.247N     P=0.256N    |P=0.524      (e)          P=0.062      (e)          | 
|POLY 6             |     P=0.113N     P=0.240N     P=0.247N     P=0.260N    |P=0.553      (e)          P=0.067      (e)          | 
|LOGISTIC REGRESSION|     P=0.122N     (e)          (e)          (e)         |(e)          (e)          P=0.086      (e)          | 
|COCH-ARM / FISHERS |     P=0.116N     P=0.247N     P=0.247N     P=0.253N    |P=0.500      (e)          P=0.059      (e)          | 
|ORDER RESTRICTED   |     P=0.037N*    (e)          (e)          (e)         |P=0.115      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    2/49 (4%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     1/46.83      2/46.01      0/44.84      2/42.71     |2/42.96      0/43.63      1/44.22      6/45.62      | 
|POLY-3 PERCENT (g) |     2.1%         4.4%         0.0%         4.7%        |4.7%         0.0%         2.3%         13.2%        | 
|TERMINAL (d)       |     1/39 (3%)    2/40 (5%)    0/38 (0%)    2/36 (6%)   |1/33 (3%)    0/33 (0%)    1/39 (3%)    5/40 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |653          ---          729 (T)      582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.438      P=0.509      P=0.505N     P=0.472     |P=0.028 *    P=0.240N     P=0.459N     P=0.192      | 
|POLY 3             |     P=0.440      P=0.494      P=0.509N     P=0.468     |P=0.016 *    P=0.234N     P=0.490N     P=0.153      | 
|POLY 1.5           |     P=0.443      P=0.493      P=0.508N     P=0.472     |P=0.016 *    P=0.233N     P=0.495N     P=0.147      | 
|POLY 6             |     P=0.437      P=0.495      P=0.509N     P=0.464     |P=0.018 *    P=0.237N     P=0.485N     P=0.160      | 
|LOGISTIC REGRESSION|     P=0.438      P=0.509      (e)          P=0.472     |P=0.018 *    P=0.235N     P=0.493N     P=0.143      | 
|COCH-ARM / FISHERS |     P=0.462      P=0.500      P=0.500N     P=0.492     |P=0.016 *    P=0.247N     P=0.500N     P=0.134      | 
|ORDER RESTRICTED   |     P=0.371      (e)          (e)          (e)         |P=0.012 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    2/50 (4%)    7/49 (14%)  |3/50 (6%)    3/50 (6%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/46.83      3/47.17      2/45.80      7/42.97     |3/42.86      3/44.19      1/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     10.7%        6.4%         4.4%         16.3%       |7.0%         6.8%         2.3%         2.2%         | 
|TERMINAL (d)       |     5/39 (13%)   1/40 (3%)    0/38 (0%)    5/36 (14%)  |2/33 (6%)    0/33 (0%)    1/39 (3%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      435          496          679         |681          653          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.195      P=0.350N     P=0.233N     P=0.322     |P=0.133N     P=0.651      P=0.259N     P=0.253N     | 
|POLY 3             |     P=0.196      P=0.353N     P=0.225N     P=0.320     |P=0.155N     P=0.648N     P=0.294N     P=0.287N     | 
|POLY 1.5           |     P=0.201      P=0.359N     P=0.229N     P=0.326     |P=0.159N     P=0.651N     P=0.300N     P=0.292N     | 
|POLY 6             |     P=0.193      P=0.346N     P=0.221N     P=0.317     |P=0.151N     P=0.651N     P=0.288N     P=0.281N     | 
|LOGISTIC REGRESSION|     P=0.230      P=0.324N     P=0.201N     P=0.307     |P=0.156N     P=0.657N     P=0.288N     P=0.281N     | 
|COCH-ARM / FISHERS |     P=0.222      P=0.357N     P=0.218N     P=0.365     |P=0.165N     P=0.661N     P=0.309N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.106      (e)          (e)          (e)         |P=0.223N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/50 (36%)  17/50 (34%)  17/50 (34%)  18/49 (37%) |5/50 (10%)   3/50 (6%)    1/50 (2%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     18/46.83     17/46.60     17/44.90     18/42.71    |5/43.04      3/44.10      1/44.22      5/46.58      | 
|POLY-3 PERCENT (g) |     38.4%        36.5%        37.9%        42.1%       |11.6%        6.8%         2.3%         10.7%        | 
|TERMINAL (d)       |     18/39 (46%)  16/40 (40%)  16/38 (42%)  18/36 (50%) |3/33 (9%)    2/33 (6%)    1/39 (3%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      545          715          729 (T)     |681          588          729 (T)      551          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.370      P=0.462N     P=0.541N     P=0.460     |P=0.529N     P=0.359N     P=0.079N     P=0.549N     | 
|POLY 3             |     P=0.371      P=0.507N     P=0.563N     P=0.444     |P=0.567      P=0.343N     P=0.095N     P=0.580N     | 
|POLY 1.5           |     P=0.393      P=0.517N     P=0.561N     P=0.462     |P=0.555      P=0.344N     P=0.098N     P=0.597N     | 
|POLY 6             |     P=0.351      P=0.494N     P=0.563N     P=0.427     |P=0.573N     P=0.350N     P=0.092N     P=0.561N     | 
|LOGISTIC REGRESSION|     P=0.346      P=0.520N     P=0.577N     P=0.460     |P=0.537      P=0.347N     P=0.094N     P=0.625      | 
|COCH-ARM / FISHERS |     P=0.488      P=0.500N     P=0.500N     P=0.553     |P=0.537      P=0.357N     P=0.102N     P=0.630N     | 
|ORDER RESTRICTED   |     P=0.512      (e)          (e)          (e)         |P=0.299N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.92      0/46.01      1/45.29      0/43.48     |2/43.53      0/43.63      1/45.22      1/46.12      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         2.2%         0.0%        |4.6%         0.0%         2.2%         2.2%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     706          ---          597          ---         |506          ---          15           105          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.424N     P=0.505N     P=0.753      P=0.520N    |P=0.491N     P=0.236N     P=0.492N     P=0.487N     | 
|POLY 3             |     P=0.415N     P=0.504N     P=0.753      P=0.515N    |P=0.490N     P=0.236N     P=0.487N     P=0.480N     | 
|POLY 1.5           |     P=0.413N     P=0.504N     P=0.752      P=0.512N    |P=0.493N     P=0.235N     P=0.490N     P=0.484N     | 
|POLY 6             |     P=0.417N     P=0.504N     P=0.753      P=0.518N    |P=0.482N     P=0.242N     P=0.483N     P=0.476N     | 
|LOGISTIC REGRESSION|     P=0.383N     P=0.501N     P=0.743N     P=0.509N    |P=0.576N     P=0.247N     P=0.456N     P=0.605N     | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.500N     P=0.753N     P=0.500N    |P=0.500N     P=0.247N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.267N     (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    4/50 (8%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.83      1/46.01      4/44.84      0/43.48     |0/42.68      1/43.91      0/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     2.1%         2.2%         8.9%         0.0%        |0.0%         2.3%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/39 (3%)    1/40 (3%)    4/38 (11%)   0/36 (0%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          653          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.478N     P=0.756N     P=0.171      P=0.516N    |P=0.431      P=0.500      (e)          P=0.538      | 
|POLY 3             |     P=0.484N     P=0.757      P=0.166      P=0.515N    |P=0.421      P=0.506      (e)          P=0.511      | 
|POLY 1.5           |     P=0.476N     P=0.756      P=0.167      P=0.512N    |P=0.416      P=0.505      (e)          P=0.508      | 
|POLY 6             |     P=0.493N     P=0.757      P=0.165      P=0.517N    |P=0.427      P=0.504      (e)          P=0.515      | 
|LOGISTIC REGRESSION|     P=0.478N     P=0.756N     P=0.171      (e)         |P=0.407      P=0.496      (e)          P=0.538      | 
|COCH-ARM / FISHERS |     P=0.444N     P=0.753N     P=0.181      P=0.500N    |P=0.405      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.191N     (e)          (e)          (e)         |P=0.261      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Polymorphonuclear                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      0/44.84      0/43.48     |0/42.68      2/43.80      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    1/33 (3%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          683          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.376N     P=0.240      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.390N     P=0.243      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.394N     P=0.242      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.387N     P=0.241      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.397N     P=0.241      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.405N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.241N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    1/50 (2%)    3/50 (6%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/46.83      2/46.01      1/44.84      3/43.48     |1/43.38      2/43.63      1/44.22      2/45.13      | 
|POLY-3 PERCENT (g) |     8.5%         4.4%         2.2%         6.9%        |2.3%         4.6%         2.3%         4.4%         | 
|TERMINAL (d)       |     4/39 (10%)   2/40 (5%)    1/38 (3%)    3/36 (8%)   |0/33 (0%)    2/33 (6%)    1/39 (3%)    2/40 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |488          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.501N     P=0.325N     P=0.187N     P=0.544N    |P=0.511      P=0.505      P=0.742N     P=0.547      | 
|POLY 3             |     P=0.477N     P=0.345N     P=0.192N     P=0.540N    |P=0.461      P=0.502      P=0.756N     P=0.514      | 
|POLY 1.5           |     P=0.473N     P=0.346N     P=0.192N     P=0.533N    |P=0.456      P=0.504      P=0.759N     P=0.510      | 
|POLY 6             |     P=0.481N     P=0.344N     P=0.192N     P=0.548N    |P=0.468      P=0.495      P=0.754N     P=0.519      | 
|LOGISTIC REGRESSION|     P=0.501N     P=0.325N     P=0.187N     P=0.544N    |P=0.448      P=0.493      P=0.762N     P=0.484      | 
|COCH-ARM / FISHERS |     P=0.456N     P=0.339N     P=0.181N     P=0.500N    |P=0.444      P=0.500      P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.317N     (e)          (e)          (e)         |P=0.460      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Mediastinum                                                                                                                | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.83      0/46.01      0/44.84      0/43.48     |0/42.68      2/43.63      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         0.0%        |0.0%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    2/33 (6%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.316N     P=0.495N     P=0.505N     P=0.516N    |P=0.363N     P=0.238      (e)          (e)          | 
|POLY 3             |     P=0.299N     P=0.504N     P=0.509N     P=0.515N    |P=0.391N     P=0.242      (e)          (e)          | 
|POLY 1.5           |     P=0.300N     P=0.504N     P=0.508N     P=0.512N    |P=0.394N     P=0.242      (e)          (e)          | 
|POLY 6             |     P=0.298N     P=0.503N     P=0.509N     P=0.517N    |P=0.388N     P=0.239      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.316N     (e)          (e)          (e)         |(e)          P=0.238      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.405N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.134N     (e)          (e)          (e)         |P=0.241N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    1/48 (2%)    0/47 (0%)    1/47 (2%)   |6/47 (13%)   4/49 (8%)    2/49 (4%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     0/44.40      1/44.16      0/42.29      1/40.67     |6/40.17      4/43.97      2/43.67      1/43.13      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         2.5%        |14.9%        9.1%         4.6%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    1/39 (3%)    0/36 (0%)    1/34 (3%)   |4/30 (13%)   2/33 (6%)    1/39 (3%)    1/38 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |603          555          653          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.378      P=0.505      (e)          P=0.478     |P=0.018N*    P=0.334N     P=0.089N     P=0.035N*    | 
|POLY 3             |     P=0.380      P=0.499      (e)          P=0.483     |P=0.024N*    P=0.313N     P=0.106N     P=0.044N*    | 
|POLY 1.5           |     P=0.384      P=0.499      (e)          P=0.486     |P=0.025N*    P=0.321N     P=0.113N     P=0.047N*    | 
|POLY 6             |     P=0.375      P=0.499      (e)          P=0.479     |P=0.023N*    P=0.312N     P=0.100N     P=0.042N*    | 
|LOGISTIC REGRESSION|     (e)          P=0.505      (e)          P=0.478     |P=0.027N*    P=0.339N     P=0.112N     P=0.046N*    | 
|COCH-ARM / FISHERS |     P=0.403      P=0.505      (e)          P=0.500     |P=0.027N*    P=0.344N     P=0.121N     P=0.052N     | 
|ORDER RESTRICTED   |     P=0.235      (e)          (e)          (e)         |P=0.021N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/48 (0%)    1/49 (2%)    0/48 (0%)   |1/47 (2%)    1/48 (2%)    5/49 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/44.12      1/44.57      0/41.62     |1/39.89      1/42.00      5/43.71      2/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |2.5%         2.4%         11.4%        4.4%         | 
|TERMINAL (d)       |     0/39 (0%)    0/39 (0%)    0/38 (0%)    0/36 (0%)   |1/32 (3%)    0/32 (0%)    5/39 (13%)   2/40 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          653          ---         |729 (T)      707          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.686      (e)          P=0.496      (e)         |P=0.406      P=0.757      P=0.153      P=0.578      | 
|POLY 3             |     P=0.659      (e)          P=0.490      (e)         |P=0.361      P=0.749N     P=0.123      P=0.543      | 
|POLY 1.5           |     P=0.666      (e)          P=0.489      (e)         |P=0.349      P=0.750N     P=0.117      P=0.536      | 
|POLY 6             |     P=0.652      (e)          P=0.492      (e)         |P=0.376      P=0.752N     P=0.129      P=0.550      | 
|LOGISTIC REGRESSION|     P=0.706      (e)          P=0.520      (e)         |P=0.384      P=0.756N     P=0.153      P=0.578      | 
|COCH-ARM / FISHERS |     P=0.691      (e)          P=0.495      (e)         |P=0.327      P=0.747N     P=0.112      P=0.523      | 
|ORDER RESTRICTED   |     P=0.373      (e)          (e)          (e)         |P=0.207      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/48 (2%)    3/49 (6%)    0/48 (0%)   |0/47 (0%)    0/48 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/46.97      1/44.12      3/44.54      0/41.62     |0/39.89      0/41.91      0/43.71      1/45.13      | 
|POLY-3 PERCENT (g) |     6.4%         2.3%         6.7%         0.0%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/39 (3%)    1/39 (3%)    1/38 (3%)    0/36 (0%)   |0/32 (0%)    0/32 (0%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     702          729 (T)      681          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.160N     P=0.314N     P=0.638      P=0.145N    |P=0.228      (e)          (e)          P=0.545      | 
|POLY 3             |     P=0.159N     P=0.328N     P=0.638      P=0.142N    |P=0.213      (e)          (e)          P=0.525      | 
|POLY 1.5           |     P=0.155N     P=0.328N     P=0.636      P=0.139N    |P=0.211      (e)          (e)          P=0.521      | 
|POLY 6             |     P=0.163N     P=0.328N     P=0.641      P=0.145N    |P=0.217      (e)          (e)          P=0.528      | 
|LOGISTIC REGRESSION|     P=0.154N     P=0.325N     P=0.640      P=0.142N    |(e)          (e)          (e)          P=0.545      | 
|COCH-ARM / FISHERS |     P=0.141N     P=0.324N     P=0.651      P=0.129N    |P=0.205      (e)          (e)          P=0.515      | 
|ORDER RESTRICTED   |     P=0.094N     (e)          (e)          (e)         |P=0.144      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/48 (4%)    4/49 (8%)    2/48 (4%)   |3/47 (6%)    6/48 (13%)   2/49 (4%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     3/46.83      2/44.12      4/44.72      2/41.62     |3/40.33      6/42.88      2/43.71      5/45.13      | 
|POLY-3 PERCENT (g) |     6.4%         4.5%         8.9%         4.8%        |7.4%         14.0%        4.6%         11.1%        | 
|TERMINAL (d)       |     3/39 (8%)    2/39 (5%)    2/38 (5%)    2/36 (6%)   |2/32 (6%)    3/32 (9%)    2/39 (5%)    5/40 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      653          729 (T)     |603          555          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.523N     P=0.500N     P=0.485      P=0.537N    |P=0.553      P=0.249      P=0.429N     P=0.469      | 
|POLY 3             |     P=0.533N     P=0.527N     P=0.475      P=0.553N    |P=0.497      P=0.272      P=0.463N     P=0.419      | 
|POLY 1.5           |     P=0.526N     P=0.528N     P=0.471      P=0.547N    |P=0.488      P=0.268      P=0.472N     P=0.412      | 
|POLY 6             |     P=0.540N     P=0.525N     P=0.482      P=0.559N    |P=0.506      P=0.270      P=0.455N     P=0.426      | 
|LOGISTIC REGRESSION|     P=0.534N     P=0.500N     P=0.473      P=0.537N    |P=0.489      P=0.255      P=0.468N     P=0.425      | 
|COCH-ARM / FISHERS |     P=0.494N     P=0.520N     P=0.489      P=0.520N    |P=0.467      P=0.254      P=0.480N     P=0.393      | 
|ORDER RESTRICTED   |     P=0.567N     (e)          (e)          (e)         |P=0.447      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Iliac                                                                                                                | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/6 (0%)     0/5 (0%)     0/5 (0%)     0/4 (0%)    |0/11 (0%)    1/13 (8%)    1/10 (10%)   3/10 (30%)   | 
|POLY-3 RATE (b)    |     0/5.50       0/5.00       0/5.00       0/3.13      |0/8.74       1/10.61      1/8.86       3/9.52       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         9.4%         11.3%        31.5%        | 
|TERMINAL (d)       |     0/3 (0%)     0/5 (0%)     0/5 (0%)     0/1 (0%)    |0/5 (0%)     0/5 (0%)     1/7 (14%)    3/8 (38%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          707          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.106      P=0.494      P=0.567      P=0.198      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.042 *    P=0.539      P=0.503      P=0.109      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.035 *    P=0.538      P=0.494      P=0.096      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.053      P=0.534      P=0.513      P=0.129      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.085      P=0.524      P=0.567      P=0.198      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.030 *    P=0.542      P=0.476      P=0.090      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.034 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Iliac                                                                                                                | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/6 (0%)     0/5 (0%)     0/5 (0%)     0/4 (0%)    |2/11 (18%)   0/13 (0%)    0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/5.50       0/5.00       0/5.00       0/3.13      |2/9.44       0/10.52      0/8.86       0/9.52       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |21.2%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/3 (0%)     0/5 (0%)     0/5 (0%)     0/1 (0%)    |1/5 (20%)    0/5 (0%)     0/7 (0%)     0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |488          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.093N     P=0.235N     P=0.203N     P=0.187N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.111N     P=0.199N     P=0.239N     P=0.223N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.194N     P=0.244N     P=0.234N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.104N     P=0.213N     P=0.233N     P=0.208N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.201N     P=0.246N     P=0.340N     P=0.440N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.123N     P=0.199N     P=0.262N     P=0.262N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.022N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Iliac                                                                                                                | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/6 (0%)     0/5 (0%)     0/5 (0%)     1/4 (25%)   |2/11 (18%)   2/13 (15%)   2/10 (20%)   2/10 (20%)   | 
|POLY-3 RATE (b)    |     0/5.50       0/5.00       0/5.00       1/3.68      |2/8.79       2/10.67      2/9.29       2/9.52       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         27.2%       |22.8%        18.7%        21.5%        21.0%        | 
|TERMINAL (d)       |     0/3 (0%)     0/5 (0%)     0/5 (0%)     0/1 (0%)    |1/5 (20%)    1/5 (20%)    1/7 (14%)    2/8 (25%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          558         |715          690          603          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.194      (e)          (e)          P=0.491     |P=0.436N     P=0.686      P=0.622N     P=0.550N     | 
|POLY 3             |     P=0.144      (e)          (e)          P=0.416     |P=0.606N     P=0.632N     P=0.686N     P=0.676N     | 
|POLY 1.5           |     P=0.146      (e)          (e)          P=0.416     |P=0.579      P=0.631N     P=0.702      P=0.702N     | 
|POLY 6             |     P=0.141      (e)          (e)          P=0.417     |P=0.563N     P=0.646N     P=0.657N     P=0.641N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.570N     P=0.698N     P=0.707      P=0.584N     | 
|COCH-ARM / FISHERS |     P=0.149      (e)          (e)          P=0.400     |P=0.529      P=0.637N     P=0.669      P=0.669      | 
|ORDER RESTRICTED   |     P=0.066      (e)          (e)          (e)         |P=0.691N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Inguinal                                                                                                             | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/6 (33%)    3/5 (60%)    4/5 (80%)    1/4 (25%)   |1/11 (9%)    0/13 (0%)    0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     2/5.78       3/5.00       4/5.00       1/3.68      |1/8.74       0/10.52      0/8.86       0/9.52       | 
|POLY-3 PERCENT (g) |     34.6%        60.0%        80.0%        27.2%       |11.5%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/3 (0%)     3/5 (60%)    4/5 (80%)    0/1 (0%)    |1/5 (20%)    0/5 (0%)     0/7 (0%)     0/8 (0%)     | 
|FIRST INCIDENCE    |     682          729 (T)      729 (T)      558         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.573      P=0.637      P=0.486      P=0.534N    |P=0.245N     P=0.500N     P=0.433N     P=0.406N     | 
|POLY 3             |     P=0.600N     P=0.417      P=0.182      P=0.667N    |P=0.339N     P=0.462N     P=0.497N     P=0.483N     | 
|POLY 1.5           |     P=0.581N     P=0.408      P=0.175      P=0.658N    |P=0.334N     P=0.462N     P=0.506N     P=0.498N     | 
|POLY 6             |     P=0.597      P=0.433      P=0.195      P=0.683N    |P=0.342N     P=0.469N     P=0.486N     P=0.463N     | 
|LOGISTIC REGRESSION|     P=0.478N     P=0.275      P=0.124      P=0.346N    |P=0.245N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.562N     P=0.392      P=0.175      P=0.667N    |P=0.322N     P=0.458N     P=0.524N     P=0.524N     | 
|ORDER RESTRICTED   |     P=0.319N     (e)          (e)          (e)         |P=0.104N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/6 (0%)     0/5 (0%)     1/5 (20%)    0/4 (0%)    |1/11 (9%)    2/13 (15%)   1/10 (10%)   3/10 (30%)   | 
|POLY-3 RATE (b)    |     0/5.50       0/5.00       1/5.00       0/3.13      |1/8.74       2/10.52      1/9.29       3/9.52       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         20.0%        0.0%        |11.5%        19.0%        10.8%        31.5%        | 
|TERMINAL (d)       |     0/3 (0%)     0/5 (0%)     1/5 (20%)    0/1 (0%)    |1/5 (20%)    2/5 (40%)    0/7 (0%)     3/8 (38%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |729 (T)      729 (T)      603          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.634      (e)          P=0.602      (e)         |P=0.392      P=0.500      P=0.721N     P=0.482      | 
|POLY 3             |     P=0.545      (e)          P=0.481      (e)         |P=0.225      P=0.568      P=0.749N     P=0.322      | 
|POLY 1.5           |     P=0.594      (e)          P=0.472      (e)         |P=0.201      P=0.567      P=0.761      P=0.293      | 
|POLY 6             |     P=0.468      (e)          P=0.497      (e)         |P=0.262      P=0.556      P=0.730N     P=0.362      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.602      (e)         |P=0.261      P=0.500      P=0.739      P=0.482      | 
|COCH-ARM / FISHERS |     P=0.653      (e)          P=0.455      (e)         |P=0.167      P=0.565      P=0.738      P=0.256      | 
|ORDER RESTRICTED   |     P=0.397      (e)          (e)          (e)         |P=0.225      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/6 (0%)     0/5 (0%)     0/5 (0%)     0/4 (0%)    |1/11 (9%)    1/13 (8%)    2/10 (20%)   0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/5.50       0/5.00       0/5.00       0/3.13      |1/9.02       1/10.52      2/8.86       0/9.52       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |11.1%        9.5%         22.6%        0.0%         | 
|TERMINAL (d)       |     0/3 (0%)     0/5 (0%)     0/5 (0%)     0/1 (0%)    |0/5 (0%)     1/5 (20%)    2/7 (29%)    0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |653          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.255N     P=0.760      P=0.588      P=0.485N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.349N     P=0.730N     P=0.493      P=0.489N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.376N     P=0.724N     P=0.483      P=0.501N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.315N     P=0.747N     P=0.502      P=0.476N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.321N     P=0.730N     P=0.510      P=0.600N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.409N     P=0.717N     P=0.462      P=0.524N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.265N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    0/50 (0%)    1/50 (2%)   |3/23 (13%)   5/20 (25%)   0/14 (0%)    1/18 (6%)    | 
|POLY-3 RATE (b)    |     0/45.83      1/45.09      0/44.84      1/43.48     |3/19.63      5/18.04      0/12.80      1/16.08      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         2.3%        |15.3%        27.7%        0.0%         6.2%         | 
|TERMINAL (d)       |     0/38 (0%)    1/40 (3%)    0/38 (0%)    1/36 (3%)   |3/15 (20%)   3/12 (25%)   0/11 (0%)    1/13 (8%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |729 (T)      683          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.389      P=0.510      (e)          P=0.489     |P=0.105N     P=0.258      P=0.174N     P=0.352N     | 
|POLY 3             |     P=0.390      P=0.497      (e)          P=0.490     |P=0.129N     P=0.297      P=0.195N     P=0.375N     | 
|POLY 1.5           |     P=0.393      P=0.496      (e)          P=0.492     |P=0.135N     P=0.291      P=0.201N     P=0.380N     | 
|POLY 6             |     P=0.387      P=0.498      (e)          P=0.487     |P=0.126N     P=0.295      P=0.190N     P=0.374N     | 
|LOGISTIC REGRESSION|     (e)          P=0.510      (e)          P=0.489     |P=0.132N     P=0.263      (e)          P=0.352N     | 
|COCH-ARM / FISHERS |     P=0.410      P=0.500      (e)          P=0.505     |P=0.151N     P=0.270      P=0.228N     P=0.402N     | 
|ORDER RESTRICTED   |     P=0.241      (e)          (e)          (e)         |P=0.081N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    2/49 (4%)    4/50 (8%)    4/50 (8%)   |17/23 (74%)  13/20 (65%)  9/14 (64%)   15/18 (83%)  | 
|POLY-3 RATE (b)    |     4/46.14      2/45.09      4/44.84      4/43.72     |17/21.33     13/18.51     9/12.80      15/17.52     | 
|POLY-3 PERCENT (g) |     8.7%         4.4%         8.9%         9.2%        |79.7%        70.2%        70.3%        85.6%        | 
|TERMINAL (d)       |     2/38 (5%)    2/40 (5%)    4/38 (11%)   3/36 (8%)   |12/15 (80%)  9/12 (75%)   9/11 (82%)   12/13 (92%)  | 
|FIRST INCIDENCE    |     672          729 (T)      729 (T)      664         |488          653          729 (T)      551          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.419      P=0.329N     P=0.634      P=0.602     |P=0.478N     P=0.430N     P=0.100N     P=0.554N     | 
|POLY 3             |     P=0.435      P=0.348N     P=0.627      P=0.613     |P=0.336      P=0.369N     P=0.415N     P=0.476      | 
|POLY 1.5           |     P=0.443      P=0.348N     P=0.630      P=0.621     |P=0.315      P=0.357N     P=0.393N     P=0.444      | 
|POLY 6             |     P=0.427      P=0.348N     P=0.624      P=0.606     |P=0.350      P=0.425N     P=0.475N     P=0.488      | 
|LOGISTIC REGRESSION|     P=0.431      P=0.344N     P=0.633      P=0.624     |P=0.339      P=0.278N     P=0.275N     P=0.443      | 
|COCH-ARM / FISHERS |     P=0.476      P=0.339N     P=0.631N     P=0.631N    |P=0.270      P=0.381N     P=0.397N     P=0.370      | 
|ORDER RESTRICTED   |     P=0.512      (e)          (e)          (e)         |P=0.282      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.84      0/46.01      1/44.84      0/43.48     |0/42.68      0/43.63      1/43.54      0/45.13      | 
|POLY-3 PERCENT (g) |     4.4%         0.0%         2.2%         0.0%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    0/40 (0%)    1/38 (3%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     725          ---          729 (T)      ---         |---          ---          690          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.201N     P=0.234N     P=0.506N     P=0.257N    |P=0.708      (e)          P=0.516      (e)          | 
|POLY 3             |     P=0.191N     P=0.236N     P=0.508N     P=0.249N    |P=0.713      (e)          P=0.504      (e)          | 
|POLY 1.5           |     P=0.190N     P=0.237N     P=0.507N     P=0.246N    |P=0.706      (e)          P=0.500      (e)          | 
|POLY 6             |     P=0.193N     P=0.235N     P=0.508N     P=0.252N    |P=0.721      (e)          P=0.509      (e)          | 
|LOGISTIC REGRESSION|     P=0.201N     P=0.234N     P=0.509N     P=0.255N    |P=0.695      (e)          P=0.497      (e)          | 
|COCH-ARM / FISHERS |     P=0.185N     P=0.242N     P=0.492N     P=0.242N    |P=0.694      (e)          P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.082N     (e)          (e)          (e)         |P=0.384      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.83      2/46.01      1/44.84      0/43.48     |0/42.68      0/43.63      0/43.39      0/45.13      | 
|POLY-3 PERCENT (g) |     2.2%         4.4%         2.2%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    2/40 (5%)    1/38 (3%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.262N     P=0.518      P=0.762      P=0.511N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.263N     P=0.501      P=0.756      P=0.510N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.260N     P=0.501      P=0.756      P=0.508N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.266N     P=0.503      P=0.756      P=0.513N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.262N     P=0.518      P=0.762      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.243N     P=0.508      P=0.747N     P=0.495N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.237N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    2/50 (4%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.83      0/46.01      2/45.29      3/43.92     |1/43.38      0/43.63      1/43.79      0/45.13      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.4%         6.8%        |2.3%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    0/40 (0%)    1/38 (3%)    1/36 (3%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          597          664         |488          ---          614          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.091      P=0.490N     P=0.498      P=0.282     |P=0.401N     P=0.492N     P=0.758N     P=0.496N     | 
|POLY 3             |     P=0.096      P=0.499N     P=0.496      P=0.290     |P=0.400N     P=0.499N     P=0.759N     P=0.492N     | 
|POLY 1.5           |     P=0.097      P=0.500N     P=0.495      P=0.293     |P=0.403N     P=0.498N     P=0.759      P=0.494N     | 
|POLY 6             |     P=0.095      P=0.498N     P=0.498      P=0.289     |P=0.395N     P=0.503N     P=0.754N     P=0.489N     | 
|LOGISTIC REGRESSION|     P=0.106      (e)          P=0.517      P=0.301     |P=0.425N     P=0.516N     P=0.763N     P=0.545N     | 
|COCH-ARM / FISHERS |     P=0.106      P=0.495N     P=0.508      P=0.316     |P=0.406N     P=0.500N     P=0.747      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.099      (e)          (e)          (e)         |P=0.243N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/49 (4%)    3/50 (6%)    1/49 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/41.68      3/43.91      1/43.71      1/44.17      | 
|POLY-3 PERCENT (g) |                                                        |4.8%         6.8%         2.3%         2.3%         | 
|TERMINAL (d)       |                                                        |2/32 (6%)    2/33 (6%)    1/39 (3%)    1/40 (3%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      653          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.215N     P=0.511      P=0.431N     P=0.422N     | 
|POLY 3             |                                                        |P=0.264N     P=0.524      P=0.483N     P=0.480N     | 
|POLY 1.5           |                                                        |P=0.271N     P=0.521      P=0.492N     P=0.486N     | 
|POLY 6             |                                                        |P=0.257N     P=0.521      P=0.474N     P=0.472N     | 
|LOGISTIC REGRESSION|                                                        |P=0.255N     P=0.517      P=0.431N     P=0.422N     | 
|COCH-ARM / FISHERS |                                                        |P=0.281N     P=0.510      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |                                                        |P=0.320N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |14/49 (29%)  16/50 (32%)  14/49 (29%)  18/49 (37%)  | 
|POLY-3 RATE (b)    |                                                        |14/42.50     16/45.16     14/44.02     18/45.05     | 
|POLY-3 PERCENT (g) |                                                        |32.9%        35.4%        31.8%        40.0%        | 
|TERMINAL (d)       |                                                        |12/32 (38%)  12/33 (36%)  12/39 (31%)  16/40 (40%)  | 
|FIRST INCIDENCE    |                                                        |603          540          687          582          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.526      P=0.454      P=0.372N     P=0.515      | 
|POLY 3             |                                                        |P=0.293      P=0.492      P=0.546N     P=0.323      | 
|POLY 1.5           |                                                        |P=0.275      P=0.480      P=0.569N     P=0.302      | 
|POLY 6             |                                                        |P=0.321      P=0.489      P=0.522N     P=0.347      | 
|LOGISTIC REGRESSION|                                                        |P=0.302      P=0.469      P=0.514N     P=0.324      | 
|COCH-ARM / FISHERS |                                                        |P=0.242      P=0.440      P=0.588N     P=0.259      | 
|ORDER RESTRICTED   |                                                        |P=0.392      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/49 (4%)    0/50 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/41.68      0/43.63      0/43.71      0/44.17      | 
|POLY-3 PERCENT (g) |                                                        |4.8%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |2/32 (6%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.094N     P=0.231N     P=0.196N     P=0.191N     | 
|POLY 3             |                                                        |P=0.116N     P=0.227N     P=0.227N     P=0.224N     | 
|POLY 1.5           |                                                        |P=0.116N     P=0.227N     P=0.232N     P=0.228N     | 
|POLY 6             |                                                        |P=0.115N     P=0.229N     P=0.221N     P=0.220N     | 
|LOGISTIC REGRESSION|                                                        |P=0.094N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.115N     P=0.242N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |                                                        |P=0.025N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/49 (6%)    2/50 (4%)    0/49 (0%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |                                                        |3/41.68      2/43.78      0/43.71      3/44.17      | 
|POLY-3 PERCENT (g) |                                                        |7.2%         4.6%         0.0%         6.8%         | 
|TERMINAL (d)       |                                                        |3/32 (9%)    1/33 (3%)    0/39 (0%)    3/40 (8%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      690          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.501N     P=0.491N     P=0.088N     P=0.556N     | 
|POLY 3             |                                                        |P=0.590N     P=0.478N     P=0.110N     P=0.636N     | 
|POLY 1.5           |                                                        |P=0.594N     P=0.479N     P=0.114N     P=0.644N     | 
|POLY 6             |                                                        |P=0.583N     P=0.481N     P=0.105N     P=0.626N     | 
|LOGISTIC REGRESSION|                                                        |P=0.550N     P=0.491N     (e)          P=0.556N     | 
|COCH-ARM / FISHERS |                                                        |P=0.594      P=0.490N     P=0.121N     P=0.661N     | 
|ORDER RESTRICTED   |                                                        |P=0.322N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/49 (4%)    1/50 (2%)    1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |                                                        |2/41.68      1/43.63      1/43.71      0/44.17      | 
|POLY-3 PERCENT (g) |                                                        |4.8%         2.3%         2.3%         0.0%         | 
|TERMINAL (d)       |                                                        |2/32 (6%)    1/33 (3%)    1/39 (3%)    0/40 (0%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.116N     P=0.489N     P=0.431N     P=0.191N     | 
|POLY 3             |                                                        |P=0.147N     P=0.484N     P=0.483N     P=0.224N     | 
|POLY 1.5           |                                                        |P=0.150N     P=0.485N     P=0.492N     P=0.228N     | 
|POLY 6             |                                                        |P=0.143N     P=0.488N     P=0.474N     P=0.220N     | 
|LOGISTIC REGRESSION|                                                        |P=0.116N     P=0.489N     P=0.431N     (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.154N     P=0.492N     P=0.500N     P=0.247N     | 
|ORDER RESTRICTED   |                                                        |P=0.108N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oviduct                                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/3 (100%)   0/1 (0%)     0/0 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |                                                        |3/3.00       0/0.47       0/0.00       0/0.00       | 
|POLY-3 PERCENT (g) |                                                        |100.0%       0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |                                                        |3/3 (100%)   0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=1.000      P=1.000N     (e)          (e)          | 
|POLY 3             |                                                        |(e)          P=0.250      (e)          (e)          | 
|POLY 1.5           |                                                        |(e)          P=0.250      (e)          (e)          | 
|POLY 6             |                                                        |(e)          P=0.250      (e)          (e)          | 
|LOGISTIC REGRESSION|                                                        |P=1.000      (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.748N     P=0.250N     (e)          (e)          | 
|ORDER RESTRICTED   |                                                        |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy Diffuse                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)   |0/50 (0%)    2/48 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.28      0/46.01      0/44.29      0/42.69     |0/42.68      2/42.26      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.7%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    1/33 (3%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          684          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.373N     P=0.240      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.387N     P=0.235      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.391N     P=0.234      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.383N     P=0.234      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.395N     P=0.233      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.403N     P=0.237      (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.235N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/49 (0%)    3/49 (6%)   |1/50 (2%)    2/48 (4%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/46.28      0/46.01      0/44.29      3/42.93     |1/42.68      2/42.09      1/44.66      3/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         7.0%        |2.3%         4.8%         2.2%         6.7%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    2/36 (6%)   |1/33 (3%)    2/33 (6%)    0/39 (0%)    3/40 (8%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          664         |729 (T)      729 (T)      603          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010 *    (e)          (e)          P=0.110     |P=0.301      P=0.500      P=0.742N     P=0.376      | 
|POLY 3             |     P=0.010 *    (e)          (e)          P=0.106     |P=0.260      P=0.495      P=0.751N     P=0.325      | 
|POLY 1.5           |     P=0.010 *    (e)          (e)          P=0.108     |P=0.255      P=0.494      P=0.756N     P=0.319      | 
|POLY 6             |     P=0.010 *    (e)          (e)          P=0.104     |P=0.268      P=0.493      P=0.745N     P=0.333      | 
|LOGISTIC REGRESSION|     P=0.010 *    (e)          (e)          P=0.111     |P=0.257      P=0.500      P=0.762      P=0.376      | 
|COCH-ARM / FISHERS |     P=0.012 *    (e)          (e)          P=0.121     |P=0.242      P=0.485      P=0.753N     P=0.309      | 
|ORDER RESTRICTED   |     P=0.006 **   (e)          (e)          (e)         |P=0.242      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Cyst Focal                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/49 (0%)    0/49 (0%)   |0/50 (0%)    2/48 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.28      0/46.01      0/44.29      0/42.69     |0/42.68      2/42.26      0/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.7%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    1/33 (3%)    0/39 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          684          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.585      P=0.240      (e)          P=0.538      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.564      P=0.235      (e)          P=0.511      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.557      P=0.234      (e)          P=0.508      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.571      P=0.234      (e)          P=0.515      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.557      P=0.233      (e)          P=0.538      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.543      P=0.237      (e)          P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.325      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    2/46 (4%)    1/47 (2%)   |2/46 (4%)    2/43 (5%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     1/45.83      0/46.01      2/41.18      1/41.95     |2/40.35      2/37.56      0/43.22      1/44.13      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.9%         2.4%        |5.0%         5.3%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/38 (3%)    0/40 (0%)    1/35 (3%)    0/36 (0%)   |2/31 (7%)    2/29 (7%)    0/38 (0%)    1/39 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          653          498         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.476      P=0.490N     P=0.478      P=0.745     |P=0.222N     P=0.672      P=0.195N     P=0.420N     | 
|POLY 3             |     P=0.466      P=0.499N     P=0.463      P=0.741     |P=0.267N     P=0.669      P=0.222N     P=0.469N     | 
|POLY 1.5           |     P=0.467      P=0.500N     P=0.463      P=0.741     |P=0.269N     P=0.668      P=0.225N     P=0.473N     | 
|POLY 6             |     P=0.466      P=0.498N     P=0.464      P=0.741     |P=0.263N     P=0.665      P=0.218N     P=0.463N     | 
|LOGISTIC REGRESSION|     P=0.512      (e)          P=0.470      P=0.731N    |P=0.222N     P=0.672      (e)          P=0.420N     | 
|COCH-ARM / FISHERS |     P=0.483      P=0.495N     P=0.476      P=0.742     |P=0.270N     P=0.666      P=0.232N     P=0.476N     | 
|ORDER RESTRICTED   |     P=0.343      (e)          (e)          (e)         |P=0.222N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/47 (0%)    0/50 (0%)    0/49 (0%)   |3/48 (6%)    1/50 (2%)    1/50 (2%)    3/46 (7%)    | 
|POLY-3 RATE (b)    |     0/44.84      0/43.75      0/44.84      0/42.71     |3/40.81      1/43.63      1/44.22      3/42.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |7.4%         2.3%         2.3%         7.1%         | 
|TERMINAL (d)       |     0/38 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |3/32 (9%)    1/33 (3%)    1/39 (3%)    3/38 (8%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.579      P=0.293N     P=0.237N     P=0.582N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.497      P=0.281N     P=0.277N     P=0.648N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.489      P=0.282N     P=0.283N     P=0.659N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.511      P=0.285N     P=0.270N     P=0.635N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.579      P=0.293N     P=0.237N     P=0.582N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.478      P=0.293N     P=0.293N     P=0.641      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.363N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    2/47 (4%)    3/50 (6%)    3/49 (6%)   |0/48 (0%)    0/50 (0%)    1/50 (2%)    0/46 (0%)    | 
|POLY-3 RATE (b)    |     1/44.84      2/43.75      3/44.84      3/42.71     |0/40.81      0/43.63      1/44.22      0/42.13      | 
|POLY-3 PERCENT (g) |     2.2%         4.6%         6.7%         7.0%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    2/40 (5%)    3/38 (8%)    3/36 (8%)   |0/32 (0%)    0/33 (0%)    1/39 (3%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.199      P=0.518      P=0.305      P=0.286     |P=0.718      (e)          P=0.539      (e)          | 
|POLY 3             |     P=0.209      P=0.491      P=0.305      P=0.288     |P=0.716      (e)          P=0.516      (e)          | 
|POLY 1.5           |     P=0.214      P=0.488      P=0.306      P=0.292     |P=0.707      (e)          P=0.512      (e)          | 
|POLY 6             |     P=0.203      P=0.497      P=0.305      P=0.285     |P=0.729      (e)          P=0.520      (e)          | 
|LOGISTIC REGRESSION|     P=0.199      P=0.518      P=0.305      P=0.286     |(e)          (e)          P=0.539      (e)          | 
|COCH-ARM / FISHERS |     P=0.238      P=0.492      P=0.324      P=0.316     |P=0.690      (e)          P=0.510      (e)          | 
|ORDER RESTRICTED   |     P=0.248      (e)          (e)          (e)         |P=0.394      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cytoplasmic Alteration Focal                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/47 (0%)    5/50 (10%)   0/49 (0%)   |2/48 (4%)    0/50 (0%)    4/50 (8%)    1/46 (2%)    | 
|POLY-3 RATE (b)    |     1/44.84      0/43.75      5/44.99      0/42.71     |2/41.24      0/43.63      4/44.22      1/42.13      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         11.1%        0.0%        |4.9%         0.0%         9.0%         2.4%         | 
|TERMINAL (d)       |     1/38 (3%)    0/40 (0%)    4/38 (11%)   0/36 (0%)   |1/32 (3%)    0/33 (0%)    4/39 (10%)   1/38 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          690          ---         |603          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.586N     P=0.490N     P=0.103      P=0.511N    |P=0.514N     P=0.236N     P=0.416      P=0.460N     | 
|POLY 3             |     P=0.588N     P=0.505N     P=0.102      P=0.510N    |P=0.572N     P=0.224N     P=0.370      P=0.493N     | 
|POLY 1.5           |     P=0.579N     P=0.507N     P=0.102      P=0.508N    |P=0.583N     P=0.224N     P=0.363      P=0.500N     | 
|POLY 6             |     P=0.597N     P=0.502N     P=0.102      P=0.511N    |P=0.556N     P=0.229N     P=0.375      P=0.485N     | 
|LOGISTIC REGRESSION|     P=0.576N     (e)          P=0.102      (e)         |P=0.574N     P=0.230N     P=0.369      P=0.512N     | 
|COCH-ARM / FISHERS |     P=0.544N     P=0.505N     P=0.112      P=0.495N    |P=0.599N     P=0.237N     P=0.359      P=0.516N     | 
|ORDER RESTRICTED   |     P=0.179      (e)          (e)          (e)         |P=0.343      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/47 (0%)    0/50 (0%)    0/49 (0%)   |3/48 (6%)    2/50 (4%)    7/50 (14%)   3/46 (7%)    | 
|POLY-3 RATE (b)    |     1/44.84      0/43.75      0/44.84      0/42.71     |3/40.86      2/43.63      7/44.22      3/42.13      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |7.3%         4.6%         15.8%        7.1%         | 
|TERMINAL (d)       |     1/38 (3%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |2/32 (6%)    2/33 (6%)    7/39 (18%)   3/38 (8%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |715          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.313N     P=0.490N     P=0.500N     P=0.511N    |P=0.557      P=0.494N     P=0.245      P=0.582N     | 
|POLY 3             |     P=0.297N     P=0.505N     P=0.500N     P=0.510N    |P=0.466      P=0.470N     P=0.190      P=0.649N     | 
|POLY 1.5           |     P=0.297N     P=0.507N     P=0.500N     P=0.508N    |P=0.446      P=0.471N     P=0.182      P=0.660N     | 
|POLY 6             |     P=0.297N     P=0.502N     P=0.500N     P=0.511N    |P=0.494      P=0.477N     P=0.198      P=0.636N     | 
|LOGISTIC REGRESSION|     P=0.313N     (e)          (e)          (e)         |P=0.534      P=0.492N     P=0.217      P=0.615N     | 
|COCH-ARM / FISHERS |     P=0.301N     P=0.505N     P=0.490N     P=0.495N    |P=0.414      P=0.480N     P=0.176      P=0.641      | 
|ORDER RESTRICTED   |     P=0.130N     (e)          (e)          (e)         |P=0.292      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      0/44.84      2/43.48     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.6%        |                                                    | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    2/36 (6%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.040 *    (e)          (e)          P=0.221     |                                                    | 
|POLY 3             |     P=0.043 *    (e)          (e)          P=0.221     |                                                    | 
|POLY 1.5           |     P=0.043 *    (e)          (e)          P=0.224     |                                                    | 
|POLY 6             |     P=0.042 *    (e)          (e)          P=0.218     |                                                    | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.221     |                                                    | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |                                                    | 
|ORDER RESTRICTED   |     P=0.024 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    1/50 (2%)    4/50 (8%)   |                                                    | 
|POLY-3 RATE (b)    |     3/47.54      1/46.09      1/45.29      4/44.27     |                                                    | 
|POLY-3 PERCENT (g) |     6.3%         2.2%         2.2%         9.0%        |                                                    | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    2/36 (6%)   |                                                    | 
|FIRST INCIDENCE    |     592          710          597          558         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.267      P=0.317N     P=0.327N     P=0.449     |                                                    | 
|POLY 3             |     P=0.285      P=0.317N     P=0.323N     P=0.461     |                                                    | 
|POLY 1.5           |     P=0.288      P=0.315N     P=0.322N     P=0.468     |                                                    | 
|POLY 6             |     P=0.282      P=0.319N     P=0.325N     P=0.454     |                                                    | 
|LOGISTIC REGRESSION|     P=0.329      P=0.277N     P=0.248N     P=0.543     |                                                    | 
|COCH-ARM / FISHERS |     P=0.302      P=0.309N     P=0.309N     P=0.500     |                                                    | 
|ORDER RESTRICTED   |     P=0.177      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  8/50 (16%)   10/50 (20%)  6/50 (12%)  |                                                    | 
|POLY-3 RATE (b)    |     11/47.24     8/46.16      10/44.90     6/43.71     |                                                    | 
|POLY-3 PERCENT (g) |     23.3%        17.3%        22.3%        13.7%       |                                                    | 
|TERMINAL (d)       |     7/39 (18%)   7/40 (18%)   9/38 (24%)   5/36 (14%)  |                                                    | 
|FIRST INCIDENCE    |     682          691          715          667         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.213N     P=0.302N     P=0.535N     P=0.204N    |                                                    | 
|POLY 3             |     P=0.195N     P=0.324N     P=0.553N     P=0.184N    |                                                    | 
|POLY 1.5           |     P=0.186N     P=0.324N     P=0.547N     P=0.176N    |                                                    | 
|POLY 6             |     P=0.206N     P=0.325N     P=0.561N     P=0.194N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.202N     P=0.317N     P=0.546N     P=0.187N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.150N     P=0.306N     P=0.500N     P=0.143N    |                                                    | 
|ORDER RESTRICTED   |     P=0.194N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/46.83      1/46.24      0/44.84      2/44.70     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         4.5%        |                                                    | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          670          ---          484         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.128      P=0.496      (e)          P=0.224     |                                                    | 
|POLY 3             |     P=0.132      P=0.497      (e)          P=0.227     |                                                    | 
|POLY 1.5           |     P=0.133      P=0.497      (e)          P=0.228     |                                                    | 
|POLY 6             |     P=0.132      P=0.499      (e)          P=0.227     |                                                    | 
|LOGISTIC REGRESSION|     P=0.178      P=0.516      (e)          P=0.341     |                                                    | 
|COCH-ARM / FISHERS |     P=0.140      P=0.500      (e)          P=0.247     |                                                    | 
|ORDER RESTRICTED   |     P=0.068      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate: Epithelium                                                                                                             | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.83      1/46.01      0/44.84      0/43.48     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         2.2%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     2/39 (5%)    1/40 (3%)    0/38 (0%)    0/36 (0%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.109N     P=0.491N     P=0.244N     P=0.256N    |                                                    | 
|POLY 3             |     P=0.103N     P=0.506N     P=0.247N     P=0.254N    |                                                    | 
|POLY 1.5           |     P=0.103N     P=0.507N     P=0.247N     P=0.251N    |                                                    | 
|POLY 6             |     P=0.104N     P=0.505N     P=0.247N     P=0.257N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.109N     P=0.491N     (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.247N     P=0.247N    |                                                    | 
|ORDER RESTRICTED   |     P=0.086N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Site of Application                                                                                                        | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.83      1/46.45      1/45.12      0/43.48     |2/43.17      1/43.63      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         2.2%         0.0%        |4.6%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    1/33 (3%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          603          653          ---         |603          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.611N     P=0.504      P=0.496      (e)         |P=0.089N     P=0.507N     P=0.228N     P=0.220N     | 
|POLY 3             |     P=0.615N     P=0.498      P=0.493      (e)         |P=0.099N     P=0.496N     P=0.232N     P=0.227N     | 
|POLY 1.5           |     P=0.611N     P=0.497      P=0.492      (e)         |P=0.100N     P=0.495N     P=0.235N     P=0.230N     | 
|POLY 6             |     P=0.618N     P=0.500      P=0.493      (e)         |P=0.097N     P=0.504N     P=0.229N     P=0.225N     | 
|LOGISTIC REGRESSION|     P=0.562N     P=0.558      P=0.525      (e)         |P=0.100N     P=0.499N     P=0.238N     P=0.244N     | 
|COCH-ARM / FISHERS |     P=0.595N     P=0.500      P=0.500      (e)         |P=0.101N     P=0.500N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.400      (e)          (e)          (e)         |P=0.068N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Site of Application - Dermis                                                                                               | 
|     Inflammation Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    9/50 (18%)   1/50 (2%)   |3/50 (6%)    2/50 (4%)    7/50 (14%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/46.83      2/46.67      9/45.12      1/43.48     |3/43.78      2/43.63      7/44.22      2/45.13      | 
|POLY-3 PERCENT (g) |     4.3%         4.3%         20.0%        2.3%        |6.9%         4.6%         15.8%        4.4%         | 
|TERMINAL (d)       |     2/39 (5%)    0/40 (0%)    8/38 (21%)   1/36 (3%)   |1/33 (3%)    2/33 (6%)    7/39 (18%)   2/40 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      603          653          729 (T)     |506          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.559      P=0.688N     P=0.025 *    P=0.528N    |P=0.430N     P=0.494N     P=0.221      P=0.442N     | 
|POLY 3             |     P=0.540      P=0.692      P=0.021 *    P=0.526N    |P=0.513N     P=0.502N     P=0.161      P=0.486N     | 
|POLY 1.5           |     P=0.556      P=0.690      P=0.021 *    P=0.521N    |P=0.521N     P=0.497N     P=0.158      P=0.489N     | 
|POLY 6             |     P=0.522      P=0.690N     P=0.021 *    P=0.531N    |P=0.500N     P=0.513N     P=0.162      P=0.483N     | 
|LOGISTIC REGRESSION|     P=0.568N     P=0.680N     P=0.022 *    P=0.528N    |P=0.518N     P=0.506N     P=0.162      P=0.515N     | 
|COCH-ARM / FISHERS |     P=0.537N     P=0.691N     P=0.026 *    P=0.500N    |P=0.537N     P=0.500N     P=0.159      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.153N     (e)          (e)          (e)         |P=0.324N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Site of Application - Epidermis                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    10/50 (20%)  1/50 (2%)   |5/50 (10%)   3/50 (6%)    7/50 (14%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     2/46.83      3/46.45      10/45.12     1/43.48     |5/44.12      3/44.15      7/44.22      7/46.32      | 
|POLY-3 PERCENT (g) |     4.3%         6.5%         22.2%        2.3%        |11.3%        6.8%         15.8%        15.1%        | 
|TERMINAL (d)       |     2/39 (5%)    2/40 (5%)    9/38 (24%)   1/36 (3%)   |1/33 (3%)    2/33 (6%)    7/39 (18%)   5/40 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      603          653          729 (T)     |506          568          729 (T)      528          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.556N     P=0.511      P=0.014 *    P=0.528N    |P=0.302      P=0.356N     P=0.469      P=0.474      | 
|POLY 3             |     P=0.565      P=0.496      P=0.011 *    P=0.526N    |P=0.228      P=0.356N     P=0.380      P=0.414      | 
|POLY 1.5           |     P=0.559N     P=0.494      P=0.011 *    P=0.521N    |P=0.218      P=0.351N     P=0.378      P=0.404      | 
|POLY 6             |     P=0.547      P=0.500      P=0.011 *    P=0.531N    |P=0.243      P=0.369N     P=0.380      P=0.422      | 
|LOGISTIC REGRESSION|     P=0.544N     P=0.500      P=0.012 *    P=0.528N    |P=0.202      P=0.366N     P=0.385      P=0.357      | 
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      P=0.014 *    P=0.500N    |P=0.200      P=0.357N     P=0.380      P=0.380      | 
|ORDER RESTRICTED   |     P=0.108N     (e)          (e)          (e)         |P=0.280      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Subcutaneous Tissue                                                                                                        | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.83      0/46.01      0/44.84      2/44.11     |1/43.38      2/44.01      0/44.22      1/45.56      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.5%        |2.3%         4.5%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    1/33 (3%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          558         |488          619          ---          604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.042 *    (e)          (e)          P=0.224     |P=0.478N     P=0.508      P=0.500N     P=0.750N     | 
|POLY 3             |     P=0.043 *    (e)          (e)          P=0.224     |P=0.491N     P=0.505      P=0.496N     P=0.750N     | 
|POLY 1.5           |     P=0.043 *    (e)          (e)          P=0.226     |P=0.494N     P=0.505      P=0.499N     P=0.753N     | 
|POLY 6             |     P=0.043 *    (e)          (e)          P=0.223     |P=0.487N     P=0.501      P=0.494N     P=0.745N     | 
|LOGISTIC REGRESSION|     P=0.051      (e)          (e)          P=0.267     |P=0.519N     P=0.485      P=0.486N     P=0.731      | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |P=0.500N     P=0.500      P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.025 *    (e)          (e)          (e)         |P=0.367N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/49 (31%)  13/50 (26%)  14/50 (28%)  13/47 (28%) |24/49 (49%)  21/49 (43%)  18/50 (36%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |     15/48.35     13/46.82     14/46.50     13/42.78    |24/45.14     21/47.08     18/46.88     13/45.83     | 
|POLY-3 PERCENT (g) |     31.0%        27.8%        30.1%        30.4%       |53.2%        44.6%        38.4%        28.4%        | 
|TERMINAL (d)       |     9/39 (23%)   10/40 (25%)  9/38 (24%)   7/35 (20%)  |15/33 (46%)  10/33 (30%)  13/39 (33%)  10/40 (25%)  | 
|FIRST INCIDENCE    |     515          603          496          474         |305          12           67           604          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.533      P=0.406N     P=0.541N     P=0.538N    |P=0.005N**   P=0.366N     P=0.086N     P=0.008N**   | 
|POLY 3             |     P=0.533      P=0.451N     P=0.550N     P=0.564N    |P=0.009N**   P=0.269N     P=0.110N     P=0.012N*    | 
|POLY 1.5           |     P=0.538N     P=0.436N     P=0.540N     P=0.546N    |P=0.009N**   P=0.280N     P=0.116N     P=0.012N*    | 
|POLY 6             |     P=0.522      P=0.465N     P=0.559N     P=0.577N    |P=0.009N**   P=0.267N     P=0.109N     P=0.012N*    | 
|LOGISTIC REGRESSION|     P=0.470N     P=0.369N     P=0.446N     P=0.428N    |P=0.010N*    P=0.356N     P=0.135N     P=0.013N*    | 
|COCH-ARM / FISHERS |     P=0.463N     P=0.387N     P=0.474N     P=0.463N    |P=0.009N**   P=0.343N     P=0.135N     P=0.015N*    | 
|ORDER RESTRICTED   |     P=0.666N     (e)          (e)          (e)         |P=0.010N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    5/50 (10%)   1/50 (2%)    1/47 (2%)   |6/49 (12%)   12/49 (24%)  12/50 (24%)  6/50 (12%)   | 
|POLY-3 RATE (b)    |     2/46.28      5/46.01      1/44.99      1/40.78     |6/42.08      12/42.91     12/44.22     6/45.13      | 
|POLY-3 PERCENT (g) |     4.3%         10.9%        2.2%         2.5%        |14.3%        28.0%        27.1%        13.3%        | 
|TERMINAL (d)       |     2/39 (5%)    5/40 (13%)   0/38 (0%)    1/35 (3%)   |5/33 (15%)   12/33 (36%)  12/39 (31%)  6/40 (15%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      690          729 (T)     |698          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.230N     P=0.226      P=0.512N     P=0.538N    |P=0.213N     P=0.088      P=0.172      P=0.485N     | 
|POLY 3             |     P=0.234N     P=0.214      P=0.510N     P=0.544N    |P=0.321N     P=0.098      P=0.112      P=0.571N     | 
|POLY 1.5           |     P=0.229N     P=0.215      P=0.509N     P=0.538N    |P=0.339N     P=0.100      P=0.107      P=0.581N     | 
|POLY 6             |     P=0.239N     P=0.213      P=0.511N     P=0.549N    |P=0.301N     P=0.089      P=0.117      P=0.562N     | 
|LOGISTIC REGRESSION|     P=0.239N     P=0.226      P=0.509N     P=0.538N    |P=0.243N     P=0.077      P=0.134      P=0.538N     | 
|COCH-ARM / FISHERS |     P=0.206N     P=0.226      P=0.492N     P=0.516N    |P=0.380N     P=0.096      P=0.104      P=0.606N     | 
|ORDER RESTRICTED   |     P=0.211N     (e)          (e)          (e)         |P=0.193N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/49 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.83      1/46.01      0/44.84      0/43.48     |2/43.35      0/42.91      2/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |4.6%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    1/40 (3%)    0/38 (0%)    0/36 (0%)   |1/33 (3%)    0/33 (0%)    2/39 (5%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |506          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.582N     P=0.505      (e)          (e)         |P=0.212N     P=0.233N     P=0.646N     P=0.214N     | 
|POLY 3             |     P=0.575N     P=0.496      (e)          (e)         |P=0.237N     P=0.239N     P=0.687N     P=0.228N     | 
|POLY 1.5           |     P=0.574N     P=0.496      (e)          (e)         |P=0.241N     P=0.239N     P=0.691N     P=0.231N     | 
|POLY 6             |     P=0.575N     P=0.497      (e)          (e)         |P=0.231N     P=0.243N     P=0.682N     P=0.225N     | 
|LOGISTIC REGRESSION|     (e)          P=0.505      (e)          (e)         |P=0.248N     P=0.250N     P=0.695      P=0.254N     | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.246N     P=0.253N     P=0.691N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.391N     (e)          (e)          (e)         |P=0.109N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/49 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.83      1/46.27      0/44.84      0/43.48     |1/43.61      1/43.44      0/44.22      2/46.08      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         0.0%        |2.3%         2.3%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          660          ---          ---         |305          568          ---          551          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.579N     P=0.500      (e)          (e)         |P=0.373      P=0.753N     P=0.504N     P=0.510      | 
|POLY 3             |     P=0.574N     P=0.498      (e)          (e)         |P=0.381      P=0.760      P=0.497N     P=0.519      | 
|POLY 1.5           |     P=0.574N     P=0.497      (e)          (e)         |P=0.376      P=0.759      P=0.500N     P=0.512      | 
|POLY 6             |     P=0.574N     P=0.499      (e)          (e)         |P=0.389      P=0.759      P=0.494N     P=0.529      | 
|LOGISTIC REGRESSION|     P=0.556N     P=0.522      (e)          (e)         |P=0.325      P=0.748      P=0.451N     P=0.419      | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.369      P=0.747      P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.392N     (e)          (e)          (e)         |P=0.293      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    2/50 (4%)   |4/50 (8%)    4/49 (8%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.83      2/46.27      3/45.07      2/43.71     |4/43.35      4/43.72      2/44.22      1/45.70      | 
|POLY-3 PERCENT (g) |     4.3%         4.3%         6.7%         4.6%        |9.2%         9.2%         4.5%         2.2%         | 
|TERMINAL (d)       |     2/39 (5%)    1/40 (3%)    2/38 (5%)    1/36 (3%)   |3/33 (9%)    2/33 (6%)    2/39 (5%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      660          669          667         |506          568          729 (T)      551          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.527      P=0.686N     P=0.486      P=0.663     |P=0.071N     P=0.634N     P=0.275N     P=0.145N     | 
|POLY 3             |     P=0.530      P=0.689      P=0.483      P=0.669     |P=0.085N     P=0.639N     P=0.328N     P=0.163N     | 
|POLY 1.5           |     P=0.537      P=0.688      P=0.482      P=0.673     |P=0.088N     P=0.641N     P=0.334N     P=0.168N     | 
|POLY 6             |     P=0.524      P=0.692      P=0.484      P=0.666     |P=0.080N     P=0.641N     P=0.321N     P=0.157N     | 
|LOGISTIC REGRESSION|     P=0.548      P=0.691      P=0.481      P=0.672     |P=0.096N     P=0.630      P=0.333N     P=0.192N     | 
|COCH-ARM / FISHERS |     P=0.569      P=0.691N     P=0.500      P=0.691N    |P=0.094N     P=0.631      P=0.339N     P=0.181N     | 
|ORDER RESTRICTED   |     P=0.598      (e)          (e)          (e)         |P=0.130N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/47 (2%)    1/48 (2%)    0/47 (0%)   |0/49 (0%)    0/48 (0%)    0/47 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/48.14      1/44.22      1/43.09      0/40.99     |0/41.96      0/42.09      0/43.26      1/46.12      | 
|POLY-3 PERCENT (g) |     8.3%         2.3%         2.3%         0.0%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/39 (3%)    0/40 (0%)    1/38 (3%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     515          545          729 (T)      ---         |---          ---          ---          105          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.042N*    P=0.189N     P=0.200N     P=0.081N    |P=0.202      (e)          (e)          P=0.504      | 
|POLY 3             |     P=0.042N*    P=0.206N     P=0.214N     P=0.083N    |P=0.213      (e)          (e)          P=0.519      | 
|POLY 1.5           |     P=0.040N*    P=0.206N     P=0.211N     P=0.080N    |P=0.211      (e)          (e)          P=0.515      | 
|POLY 6             |     P=0.043N*    P=0.205N     P=0.218N     P=0.087N    |P=0.217      (e)          (e)          P=0.522      | 
|LOGISTIC REGRESSION|     P=0.025N*    P=0.118N     P=0.144N     P=0.038N*   |P=0.099      (e)          (e)          P=0.369      | 
|COCH-ARM / FISHERS |     P=0.038N*    P=0.201N     P=0.194N     P=0.066N    |P=0.203      (e)          (e)          P=0.505      | 
|ORDER RESTRICTED   |     P=0.020N*    (e)          (e)          (e)         |P=0.138      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/47 (4%)    1/44 (2%)    2/47 (4%)    0/46 (0%)   |0/46 (0%)    0/48 (0%)    0/44 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     2/44.38      1/40.97      2/42.02      0/40.71     |0/38.72      0/42.72      0/38.87      0/42.13      | 
|POLY-3 PERCENT (g) |     4.5%         2.4%         4.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    0/36 (0%)    2/36 (6%)    0/34 (0%)   |0/30 (0%)    0/33 (0%)    0/35 (0%)    0/37 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      670          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.225N     P=0.515N     P=0.676      P=0.263N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.217N     P=0.528N     P=0.674      P=0.257N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.213N     P=0.529N     P=0.676      P=0.253N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.223N     P=0.526N     P=0.672      P=0.261N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.214N     P=0.526N     P=0.676      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.200N     P=0.525N     P=0.692N     P=0.253N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.171N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    0/44 (0%)    0/47 (0%)    0/46 (0%)   |5/46 (11%)   4/48 (8%)    4/44 (9%)    1/47 (2%)    | 
|POLY-3 RATE (b)    |     1/44.38      0/40.74      0/42.02      0/40.71     |5/38.72      4/42.72      4/39.31      1/42.13      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |12.9%        9.4%         10.2%        2.4%         | 
|TERMINAL (d)       |     1/38 (3%)    0/36 (0%)    0/36 (0%)    0/34 (0%)   |5/30 (17%)   4/33 (12%)   3/35 (9%)    1/37 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |729 (T)      729 (T)      603          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.318N     P=0.511N     P=0.511N     P=0.522N    |P=0.047N*    P=0.439N     P=0.414N     P=0.061N     | 
|POLY 3             |     P=0.302N     P=0.517N     P=0.511N     P=0.517N    |P=0.069N     P=0.438N     P=0.490N     P=0.082N     | 
|POLY 1.5           |     P=0.303N     P=0.517N     P=0.510N     P=0.514N    |P=0.073N     P=0.447N     P=0.510N     P=0.086N     | 
|POLY 6             |     P=0.300N     P=0.517N     P=0.512N     P=0.521N    |P=0.063N     P=0.436N     P=0.467N     P=0.077N     | 
|LOGISTIC REGRESSION|     P=0.318N     (e)          (e)          (e)         |P=0.063N     P=0.439N     P=0.492N     P=0.061N     | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.516N     P=0.500N     P=0.505N    |P=0.080N     P=0.473N     P=0.529N     P=0.097N     | 
|ORDER RESTRICTED   |     P=0.136N     (e)          (e)          (e)         |P=0.068N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.28      0/46.01      0/44.84      0/43.48     |0/42.68      2/43.63      3/44.22      1/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.6%         6.8%         2.2%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    2/33 (6%)    3/39 (8%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.524      P=0.238      P=0.152      P=0.538      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.479      P=0.242      P=0.125      P=0.511      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.468      P=0.242      P=0.122      P=0.508      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.493      P=0.239      P=0.128      P=0.515      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.238      P=0.152      P=0.538      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.444      P=0.247      P=0.121      P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.191      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.28      3/46.01      0/44.84      0/43.48     |0/42.68      2/44.10      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     2.2%         6.5%         0.0%         0.0%        |0.0%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/39 (3%)    3/40 (8%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    1/33 (3%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          588          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.167N     P=0.314      P=0.505N     P=0.516N    |P=0.383N     P=0.242      (e)          (e)          | 
|POLY 3             |     P=0.163N     P=0.303      P=0.506N     P=0.512N    |P=0.389N     P=0.244      (e)          (e)          | 
|POLY 1.5           |     P=0.161N     P=0.304      P=0.505N     P=0.509N    |P=0.394N     P=0.243      (e)          (e)          | 
|POLY 6             |     P=0.166N     P=0.302      P=0.507N     P=0.516N    |P=0.386N     P=0.243      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.167N     P=0.314      (e)          (e)         |P=0.410N     P=0.234      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.150N     P=0.316      P=0.495N     P=0.495N    |P=0.405N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.125N     (e)          (e)          (e)         |P=0.243N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Degeneration Cystic Focal                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    6/50 (12%)   8/50 (16%)   6/50 (12%)  |14/50 (28%)  14/50 (28%)  18/50 (36%)  12/50 (24%)  | 
|POLY-3 RATE (b)    |     4/46.49      6/46.24      8/45.46      6/44.22     |14/45.53     14/45.20     18/45.16     12/45.70     | 
|POLY-3 PERCENT (g) |     8.6%         13.0%        17.6%        13.6%       |30.8%        31.0%        39.9%        26.3%        | 
|TERMINAL (d)       |     3/39 (8%)    4/40 (10%)   5/38 (13%)   4/36 (11%)  |7/33 (21%)   8/33 (24%)   15/39 (39%)  11/40 (28%)  | 
|FIRST INCIDENCE    |     672          691          653          558         |365          568          579          551          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.268      P=0.381      P=0.170      P=0.320     |P=0.215N     P=0.577N     P=0.424      P=0.263N     | 
|POLY 3             |     P=0.284      P=0.366      P=0.166      P=0.338     |P=0.386N     P=0.581      P=0.245      P=0.404N     | 
|POLY 1.5           |     P=0.294      P=0.368      P=0.167      P=0.346     |P=0.386N     P=0.588N     P=0.245      P=0.401N     | 
|POLY 6             |     P=0.275      P=0.365      P=0.166      P=0.331     |P=0.385N     P=0.558      P=0.245      P=0.411N     | 
|LOGISTIC REGRESSION|     P=0.305      P=0.367      P=0.170      P=0.363     |P=0.369N     P=0.587N     P=0.267      P=0.404N     | 
|COCH-ARM / FISHERS |     P=0.341      P=0.383      P=0.188      P=0.383     |P=0.396N     P=0.588N     P=0.260      P=0.410N     | 
|ORDER RESTRICTED   |     P=0.259      (e)          (e)          (e)         |P=0.345N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/49 (14%)   7/50 (14%)   8/50 (16%)   3/50 (6%)   |1/50 (2%)    11/50 (22%)  9/50 (18%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     7/46.28      7/46.01      8/44.90      3/43.80     |1/42.68      11/43.96     9/44.51      4/45.17      | 
|POLY-3 PERCENT (g) |     15.1%        15.2%        17.8%        6.9%        |2.3%         25.0%        20.2%        8.9%         | 
|TERMINAL (d)       |     7/39 (18%)   7/40 (18%)   7/38 (18%)   2/36 (6%)   |1/33 (3%)    9/33 (27%)   8/39 (21%)   3/40 (8%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      713          642         |729 (T)      683          653          718          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.170N     P=0.595N     P=0.478      P=0.192N    |P=0.472N     P=0.003 **   P=0.018 *    P=0.243      | 
|POLY 3             |     P=0.159N     P=0.609      P=0.475      P=0.181N    |P=0.554      P=0.002 **   P=0.009 **   P=0.196      | 
|POLY 1.5           |     P=0.153N     P=0.610      P=0.479      P=0.175N    |P=0.531      P=0.002 **   P=0.009 **   P=0.191      | 
|POLY 6             |     P=0.166N     P=0.608      P=0.471      P=0.186N    |P=0.543N     P=0.002 **   P=0.010 *    P=0.203      | 
|LOGISTIC REGRESSION|     P=0.171N     P=0.595N     P=0.458      P=0.189N    |P=0.554N     P=0.002 **   P=0.012 *    P=0.215      | 
|COCH-ARM / FISHERS |     P=0.124N     P=0.597N     P=0.517      P=0.151N    |P=0.486      P=0.002 **   P=0.008 **   P=0.181      | 
|ORDER RESTRICTED   |     P=0.160N     (e)          (e)          (e)         |P=0.021 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     18/18 (100%) 11/11 (100%) 15/15 (100%) 12/12 (100%)|0/1 (0%)     1/1 (100%)   0/1 (0%)     1/2 (50%)    | 
|POLY-3 RATE (b)    |     18/18.00     11/11.00     15/15.00     12/12.00    |0/0.30       1/1.00       0/1.00       1/1.57       | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       100.0%      |0.0%         100.0%       0.0%         63.7%        | 
|TERMINAL (d)       |     16/16 (100%) 10/10 (100%) 13/13 (100%) 10/10 (100%)|0/0 (0%)     0/0 (0%)     0/1 (0%)     1/1 (100%)   | 
|FIRST INCIDENCE    |     640          710          690          573         |---          653          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.685      P=0.506      (e)          P=1.000N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.703N     P=1.000N     (e)          P=0.764      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.690      P=1.000N     (e)          P=0.691      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.752N     P=1.000N     (e)          P=0.896      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.710N     (e)          (e)          P=1.000N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.590      P=0.500      (e)          P=0.667      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.566      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.83      1/46.24      0/44.29      2/44.70     |0/42.68      0/43.63      0/44.22      0/45.13      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/39 (0%)    0/40 (0%)    0/38 (0%)    0/36 (0%)   |0/33 (0%)    0/33 (0%)    0/39 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          670          ---          484         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.128      P=0.496      (e)          P=0.224     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.133      P=0.497      (e)          P=0.227     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.133      P=0.497      (e)          P=0.228     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.133      P=0.499      (e)          P=0.227     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.179      P=0.516      (e)          P=0.341     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.140      P=0.500      (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.068      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   8/50 (16%)   6/50 (12%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |5/43.07      8/45.24      6/44.39      2/45.84      | 
|POLY-3 PERCENT (g) |                                                        |11.6%        17.7%        13.5%        4.4%         | 
|TERMINAL (d)       |                                                        |4/33 (12%)   3/33 (9%)    5/39 (13%)   1/40 (3%)    | 
|FIRST INCIDENCE    |                                                        |619          568          687          481          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.075N     P=0.289      P=0.600      P=0.166N     | 
|POLY 3             |                                                        |P=0.090N     P=0.307      P=0.521      P=0.191N     | 
|POLY 1.5           |                                                        |P=0.097N     P=0.299      P=0.510      P=0.199N     | 
|POLY 6             |                                                        |P=0.083N     P=0.311      P=0.533      P=0.184N     | 
|LOGISTIC REGRESSION|                                                        |P=0.110N     P=0.279      P=0.529      P=0.218N     | 
|COCH-ARM / FISHERS |                                                        |P=0.113N     P=0.277      P=0.500      P=0.218N     | 
|ORDER RESTRICTED   |                                                        |P=0.098N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/19/04                           EXPERIMENT: 93020 TEST: 08                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                 DIISOPROPYLCARBODIIMIDE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG    |0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |46/50 (92%)  44/50 (88%)  47/50 (94%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |                                                        |46/48.88     44/47.67     47/47.19     49/49.00     | 
|POLY-3 PERCENT (g) |                                                        |94.1%        92.3%        99.6%        100.0%       | 
|TERMINAL (d)       |                                                        |31/33 (94%)  32/33 (97%)  39/39 (100%) 40/40 (100%) | 
|FIRST INCIDENCE    |                                                        |305          555          560          481          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.192N     P=0.421N     P=0.196N     P=0.243N     | 
|POLY 3             |                                                        |P=0.026 *    P=0.522N     P=0.160      P=0.125      | 
|POLY 1.5           |                                                        |P=0.029 *    P=0.445N     P=0.202      P=0.127      | 
|POLY 6             |                                                        |P=0.027 *    P=0.643N     P=0.144      P=0.130      | 
|LOGISTIC REGRESSION|                                                        |P=0.090      P=0.282N     P=0.485      P=0.238      | 
|COCH-ARM / FISHERS |                                                        |P=0.080      P=0.370N     P=0.500      P=0.181      | 
|ORDER RESTRICTED   |                                                        |P=0.030 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).