Share This:
https://ntp.niehs.nih.gov/go/19903

TDMS Study 93027-34 Pathology Tables

NTP Experiment-Test: 93027-34         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           PEROXISOME PROJECT (WY-14643)                               Date: 07/08/99
Route: DOSED FEED                                                                                                 Time: 10:02:38

                                                       13 WEEK SUBCHRONIC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  50892-23-4

       Lock Date:  06/12/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 93027-34         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           PEROXISOME PROJECT (WY-14643)                               Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 10:02:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        5 PPM        10 PPM       50 PPM       100 PPM      500 PPM         
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Clear Cell Focus                                 1 (10%)                                                                      
      Cytoplasmic Alteration                                       10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Infiltration Cellular, Mononuclear Cell          3 (30%)      1 (10%)      1 (10%)      2 (20%)                   1 (10%)     
      Infiltration Cellular, Mixed Cell                5 (50%)      2 (20%)      6 (60%)      3 (30%)      7 (70%)                  
      Mitotic Alteration                                                                      4 (40%)      7 (70%)     10 (100%)    
      Necrosis, Focal                                                            1 (10%)      1 (10%)      2 (20%)                  
      Pigmentation                                                                                         3 (30%)     10 (100%)    
      Hepatocyte, Hyperplasia                                                                                           1 (10%)     
      Oval Cell, Hyperplasia                                                                                           10 (100%)    
   Pancreas                                           (10)         (5)          (10)         (10)         (10)         (10)         
      Inflammation, Chronic                                                                   1 (10%)      1 (10%)      3 (30%)     
   Stomach, Glandular                                 (10)                                                             (10)         
      Inflammation, Chronic Active                     2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 93027-34         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           PEROXISOME PROJECT (WY-14643)                               Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 10:02:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        5 PPM        10 PPM       50 PPM       100 PPM      500 PPM         
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)         (4)          (8)          (10)         (10)         (10)         
      Inflammation, Chronic                                         3 (75%)      1 (13%)      4 (40%)      2 (20%)                  
   Testes                                             (10)         (5)          (10)         (10)         (10)         (10)         
      Atrophy                                                                                              1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                             (10)         
      Congestion                                                                                                        1 (10%)     
      Hemorrhage                                                                                                        5 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (5)          (10)         (10)         (10)         (10)         
      Nephropathy                                                   3 (60%)      4 (40%)      4 (40%)      3 (30%)                  
   Urinary Bladder                                    (10)                                                             (10)         
      Infiltration Cellular                            3 (30%)                                                          1 (10%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 93027-34         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                           PEROXISOME PROJECT (WY-14643)                               Date: 07/08/99  
Route: DOSED FEED                                                                                                 Time: 10:02:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        5 PPM        10 PPM       50 PPM       100 PPM      500 PPM         
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                     1 (10%)                                                          1 (10%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------