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TDMS Study 96022-02 Pathology Tables

NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04
Route: GAVAGE                                                                                                     Time: 13:17:20

                                                      31 WEEK SSAC/FINAL#1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFPCBMIX

       Lock Date:  11/04/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     05/16/00 - 05/17/00

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 002    80 NG  /10 UG
                               Include 003    240 NG /30 UG
                               Include 004    800 NG /100 UG
                               Include 005    2400 NG/300 UG
                               Include 006    4000 NG/500 UG































                                                              Page   1


NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG /                                 | 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 7| 7| 7| 7| 7|                          |      L     |
    0 UG                                   | 6| 7| 8| 9| 5| 6| 7| 8| 9| 0| 3| 1| 2| 3| 4| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |                +  +  +  +  +     +  +  +  +  +                           |  10        |
      Basophilic Focus                     |                   X                                                      |      1     |
      Cholangiofibrosis                    |                                     1                                    |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                        X                                 |      1     |
      Inflammation                         |                1  1  1  1  2     2  1  1  1  1                           |     10  1.2|
      Mixed Cell Focus                     |                                        X  X  X                           |      3     |
      Mixed Cell Focus, Multiple           |                   X                 X                                    |      2     |
      Necrosis                             |                      1                                                   |      1  1.0|
      Pigmentation                         |                         1                    1                           |      2  1.0|
      Bile Duct, Fibrosis                  |                                        1                                 |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |                +  +  +  +  +     +  +  +  +  +                           |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +  +  +  +     +  +  +  +  +                           |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +  +  +  +     +  +  +  +  +                           |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |                +  +  +  +  +     +  +  +  +  +                           |  10        |
      Hypertrophy                          |                1  2                 1     1  1                           |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |                +  +  +  +  +     +  +  +  +  +                           |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +  +  +  +     +  +  +  +  +                           |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +  +  +  +     +  +  +  +  +                           |  10        |
      Cyst                                 |                      1                                                   |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +  +  +     +  +  +  +  +                           |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG /                                 | 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 7| 7| 7| 7| 7|                          |      L     |
    0 UG                                   | 6| 7| 8| 9| 5| 6| 7| 8| 9| 0| 3| 1| 2| 3| 4| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Follicular Cell, Hypertrophy         |                2                          1  1                           |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |                +  +  +  +  +     +  +  +  +  +                           |  10        |
      Atrophy                              |                3  3  3  3  3              3                              |      6  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |                +  +  +  +  +     +  +  +  +  +                           |  10        |
      Inflammation, Suppurative            |                         3                                                |      1  3.0|
      Metaplasia, Squamous                 |                1  2  1     2              2                              |      5  1.6|
      Endometrium, Hyperplasia, Cystic     |                1  2     1  2              2                              |      5  1.6|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                +  +  +  +  +     +  +  +  +  +                           |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |                +  +  +  +  +     +  +  +  +  +                           |  10        |
      Pigmentation                         |                1  1  1  2  1     1  2  1  1  1                           |     10  1.2|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |                +  +  +  +  +     +  +  +  +  +                           |  10        |
      Atrophy                              |                1  1                       2                              |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                +  +  +  +  +     +  +  +  +  +                           |  10        |
      Hyperplasia                          |                                     1  1                                 |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG /                                 | 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 7| 7| 7| 7| 7|                          |      L     |
    0 UG                                   | 6| 7| 8| 9| 5| 6| 7| 8| 9| 0| 3| 1| 2| 3| 4| 5|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |                +  +  +  +  +     +  +  +  +  +                           |  10        |
      Hemorrhage                           |                   2                    2                                 |      2  2.0|
      Infiltration Cellular, Histiocyte    |                         1        1     1                                 |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    80 NG  /                               | 0| 0| 0| 0| 0| 7| 7| 7| 7| 7|                                            |      L     |
    10 UG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         | 1  1  1  1  1  1  1  1  1  2                                             |     10  1.1|
      Mixed Cell Focus                     |    X  X  X              X  X                                             |      5     |
      Mixed Cell Focus, Multiple           | X           X     X                                                      |      3     |
      Necrosis                             |                         1                                                |      1  1.0|
      Pigmentation                         | 1  1        1           1                                                |      4  1.0|
      Hepatocyte, Hypertrophy              |       1              1                                                   |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Angiectasis                          | 1  1  1  1           1  1                                                |      6  1.0|
      Degeneration, Cystic                 |                         2                                                |      1  2.0|
      Hypertrophy                          | 2                 2  1  2                                                |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |       +                                                                  |   1        |
      Angiectasis                          |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Follicular Cell, Hypertrophy         | 1                 1  1                                                   |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |    3  3  3     3  3  3  3                                                |      7  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    80 NG  /                               | 0| 0| 0| 0| 0| 7| 7| 7| 7| 7|                                            |      L     |
    10 UG                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Metaplasia, Squamous                 |    2  1  1     2  2  2                                                   |      6  1.7|
      Endometrium, Hyperplasia, Cystic     |    2  2        2  3  2                                                   |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |    2                 1                                                   |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Histiocyte    |             1              1                                             |      2  1.0|
      Inflammation                         |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |      A     |
    240 NG /                               | 2| 3| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 9|                          |      L     |
    30 UG                                  | 8| 7| 8| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 7|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |             +  +  +  +  +  +  +  +  +  +                                 |  10        |
      Inflammation                         |             2  1  2  1  1  1  1  1  1  1                                 |     10  1.2|
      Mixed Cell Focus                     |             X                                                            |      1     |
      Mixed Cell Focus, Multiple           |                   X                                                      |      1     |
      Necrosis                             |             2                                                            |      1  2.0|
      Pigmentation                         |             2  1  1  1  1  1  1  1     1                                 |      9  1.1|
      Hepatocyte, Hypertrophy              |                1  1     1  1                                             |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |             +  +  +  +  +  +  +  +  +  +                                 |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |                      +                                                   |   1        |
      Serosa, Inflammation, Chronic Active |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |             +  +  +  +  +  +  +  +  +  +                                 |  10        |
      Angiectasis                          |                               1     1                                    |      2  1.0|
      Hypertrophy                          |                         1        1     1                                 |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |             +  +  +  +  +  +  +  +  +  +                                 |  10        |
      Follicular Cell, Hypertrophy         |             1  1  1  2  2     1  1                                       |      7  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |             +  +  +  +  +  +  +  +  +  +                                 |  10        |
      Atrophy                              |                3     3  3     3  3  2  3                                 |      7  2.9|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |      A     |
    240 NG /                               | 2| 3| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 9|                          |      L     |
    30 UG                                  | 8| 7| 8| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 7|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Uterus                                  |             +  +  +  +  +  +  +  +  +  +                                 |  10        |
      Decidual Reaction                    |             X                                                            |      1     |
      Metaplasia, Squamous                 |                2     2  1     1  2     2                                 |      6  1.7|
      Endometrium, Hyperplasia, Cystic     |                2     2  1     1     3  1                                 |      6  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |             +  +  +  +  +  +  +  +  +  +                                 |  10        |
      Atrophy                              |             1     2  2  1        2                                       |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |             +  +  +  +  +  +  +  +  +  +                                 |  10        |
      Infiltration Cellular, Histiocyte    |                         1  1        1  1                                 |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    800 NG /                               | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7|                                            |      L     |
    100 UG                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cholangiofibrosis                    |       2     1                                                            |      2  1.5|
      Fatty Change, Diffuse                |       2  1              2                                                |      3  1.7|
      Hepatodiaphragmatic Nodule           |                X                                                         |      1     |
      Inflammation                         | 2  2  1  2  2  2  1  3  2  1                                             |     10  1.8|
      Mixed Cell Focus, Multiple           | X  X        X     X  X     X                                             |      6     |
      Pigmentation                         | 1  1  1  2  1  1  1  2  1  1                                             |     10  1.2|
      Toxic Hepatopathy                    |       1     1        1                                                   |      3  1.0|
      Bile Duct, Fibrosis                  |    1                                                                     |      1  1.0|
      Bile Duct, Hyperplasia               |                      1                                                   |      1  1.0|
      Centrilobular, Fibrosis              |             1     1  1                                                   |      3  1.0|
      Hepatocyte, Hypertrophy              |       2  1  1  1  1  1  1  1                                             |      8  1.1|
      Hepatocyte, Multinucleated           | 1           1        1                                                   |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Acinus, Vacuolization Cytoplasmic    | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypertrophy                          | 2           1        2                                                   |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Follicular Cell, Hypertrophy         | 1  2     1  2  2  1  1                                                   |      7  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    800 NG /                               | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7|                                            |      L     |
    100 UG                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 3           3     3     3                                                |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Metaplasia, Squamous                 | 2  2              1     2                                                |      4  1.8|
      Endometrium, Hyperplasia, Cystic     | 2  1                    1                                                |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +                                             |   9        |
      Atrophy                              | 2  2     2  2  3  2  2  4  2                                             |      9  2.3|
      Cyst                                 |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           |       2                                                                  |      1  2.0|
      Infiltration Cellular, Histiocyte    |       1                    1                                             |      2  1.0|
      Inflammation, Granulomatous          |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    800 NG /                               | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7|                                            |      L     |
    100 UG                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    2400 NG/                               | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 5| 5| 7| 8| 8|                          |      L     |
    300 UG                                 | 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 5| 6| 8| 3| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Cholangiofibrosis                    |                   1           2                                          |      2  1.5|
      Eosinophilic Focus                   |       X              X     X                                             |      3     |
      Eosinophilic Focus, Multiple         |    X        X     X           X                                          |      4     |
      Fatty Change, Diffuse                | 1        2  1     2  1  2  1  1                                          |      8  1.4|
      Hyperplasia, Nodular                 |                               X                                          |      1     |
      Infarct                              |                               3                                          |      1  3.0|
      Inflammation                         | 2  2  2  2  1     1  1  2  2  1                                          |     10  1.6|
      Necrosis                             | 1     1                                                                  |      2  1.0|
      Pigmentation                         | 2  2  2  2  3     2  2  2  2  2                                          |     10  2.1|
      Toxic Hepatopathy                    | 2  2  2  2  2     2  2  2  2  3                                          |     10  2.1|
      Bile Duct, Hyperplasia               | 2  2  2  1  2     1  1  1  1  2                                          |     10  1.5|
      Centrilobular, Fibrosis              | 2  2  2  2  2     2  2  1  2  1                                          |     10  1.8|
      Hepatocyte, Hypertrophy              | 3  3  2  3  3     3  3  2  3  3                                          |     10  2.8|
      Hepatocyte, Multinucleated           | 3  2  2  2  2     2  2  2  2  3                                          |     10  2.2|
      Oval Cell, Hyperplasia               | 1  2  2  1  1     1  1        1                                          |      8  1.3|
      Portal, Fibrosis                     |                               2                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Acinus, Atrophy                      |    1                                                                     |      1  1.0|
      Acinus, Vacuolization Cytoplasmic    | 1  2  1  1  1     1  1  1  1  1                                          |     10  1.1|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Angiectasis                          |    1                                                                     |      1  1.0|
      Atrophy                              |    1                          1                                          |      2  1.0|
      Hypertrophy                          |       1                 1  1                                             |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +                                          |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    2400 NG/                               | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 5| 5| 7| 8| 8|                          |      L     |
    300 UG                                 | 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 5| 6| 8| 3| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Follicular Cell, Hypertrophy         | 2  2  2     2     1  2  1  2  2                                          |      9  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Atrophy                              |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Metaplasia, Squamous                 |                      2                                                   |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Atrophy                              | 4  2  4  4  4     4  3  3     3                                          |      9  3.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +  +                                          |  10        |
      Hemorrhage                           |             1                                                            |      1  1.0|
      Infiltration Cellular, Histiocyte    | 1           1        1     1  1                                          |      5  1.0|
      Inflammation, Granulomatous          |                   1     1                                                |      2  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    2400 NG/                               | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 5| 5| 7| 8| 8|                          |      L     |
    300 UG                                 | 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 5| 6| 8| 3| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 2           1                 1                                          |      3  1.3|
      Interstitium, Fibrosis, Focal        |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    4000 NG/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|                                            |      L     |
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cholangiofibrosis                    |             1                                                            |      1  1.0|
      Eosinophilic Focus                   |             X  X                                                         |      2     |
      Eosinophilic Focus, Multiple         |          X              X  X                                             |      3     |
      Fatty Change, Diffuse                | 1  1  2  1  1     1  2  1  3                                             |      9  1.4|
      Hyperplasia, Nodular                 | X  X  X           X                                                      |      4     |
      Inflammation                         | 2  2  1  2  2  1  1  1  1  1                                             |     10  1.4|
      Pigmentation                         | 2  3  2  3  3  3  3  2  3  2                                             |     10  2.6|
      Toxic Hepatopathy                    | 3  3  2  2  3  3  3  3  3  3                                             |     10  2.8|
      Bile Duct, Hyperplasia               | 2  2  1  1  1  1  1  1  1  1                                             |     10  1.2|
      Centrilobular, Fibrosis              | 3  3  2  2  2  3  2  2  2  2                                             |     10  2.3|
      Hepatocyte, Hypertrophy              | 4  4  4  3  3  3  3  3  3  4                                             |     10  3.4|
      Hepatocyte, Multinucleated           | 2  3  2  3  3  2  3  3  3  2                                             |     10  2.6|
      Oval Cell, Hyperplasia               | 2  2  1  1  1  2  1  1  1  1                                             |     10  1.3|
      Portal, Fibrosis                     | 3  2           2  2                                                      |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |          1                 1                                             |      2  1.0|
      Acinus, Atrophy                      |       1  1                                                               |      2  1.0|
      Acinus, Vacuolization Cytoplasmic    | 1  1  2  1  1  1  1  1  1  1                                             |     10  1.1|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Angiectasis                          |       1                                                                  |      1  1.0|
      Atrophy                              | 2  2  2  2     2  2     1  1                                             |      8  1.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    4000 NG/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|                                            |      L     |
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hypertrophy                          |          2                                                               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |                            2                                             |      1  2.0|
      Cytoplasmic Alteration               |                            2                                             |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
      Follicular Cell, Hypertrophy         | 1        1  2  2  1  1     4                                             |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Endometrium, Hyperplasia, Cystic     |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pigmentation                         | 1  1  2  1  1  1  1  2  2  1                                             |     10  1.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  M  M                                             |   6        |
      Atrophy                              | 4  4  4  3  3        4                                                   |      6  3.7|
 _____________________________________________________________________________________________________________________|            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:17:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    4000 NG/                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|                                            |      L     |
    500 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Histiocyte    |                1  1                                                      |      2  1.0|
      Inflammation, Granulomatous          |             1     2                                                      |      2  1.5|
      Metaplasia, Squamous                 |                1                                                         |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                1                                                         |      1  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |    1     1        2                                                      |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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