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TDMS Study 96022-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 04/27/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 13:18:05       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                        31 WEEK SSAC/FINAL#1                                                        
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25017 Scheduled Sacrifice                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     051600 051700                                                                                
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 NG /  0 UG                                                                  
                                       INCLUDE 002    80 NG  /10 UG                                                                 
                                       INCLUDE 003    240 NG /30 UG                                                                 
                                       INCLUDE 004    800 NG /100 UG                                                                
                                       INCLUDE 005    2400 NG/300 UG                                                                
                                       INCLUDE 006    4000 NG/500 UG                                                                
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 04/27/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 13:18:05       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF      TEF EVALUATION (PCB MIXTURE;PCB 126/P                                                                       
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Angiectasis                                                                                  
                                       Atrophy                                                                                      
                                       Hypertrophy                                                                                  
Liver                                  Eosinophilic Focus                                                                           
                                       Fatty Change Diffuse                                                                         
                                       Hyperplasia                                                                                  
                                       Mixed Cell Focus                                                                             
                                       Pigmentation                                                                                 
                                       Toxic Hepatopathy                                                                            
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Centrilobular                   Fibrosis                                                                                     
Liver: Hepatocyte                      Hypertrophy                                                                                  
                                       Multinucleated                                                                               
Liver: Oval Cell                       Hyperplasia                                                                                  
Liver: Portal                          Fibrosis                                                                                     
Lung                                   Inflammation Granulomatous                                                                   
Lung: Alveolar Epithelium              Metaplasia Bronchiolar                                                                       
Ovary                                  Atrophy                                                                                      
Pancreas                               Inflammation Chronic                                                                         
Pancreas: Acinus                       Atrophy                                                                                      
                                       Vacuolization Cytoplasmic                                                                    
Thymus                                 Atrophy                                                                                      
Thyroid Gland: Follicular Cell         Hypertrophy                                                                                  
Uterus                                 Metaplasia                                                                                   
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P        
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        6/10 (60%)       2/10 (20%)       0/10 (0%)        1/10 (10%)       1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/0.10           6/6.04           2/2.08           0/0.10           1/1.09           1/1.09          | 
|POLY-3 PERCENT (g) |        0.0%             99.3%            96.1%            0.0%             91.7%            91.7%           | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        6/10 (60%)       2/10 (20%)       0/10 (0%)        1/10 (10%)       1/10 (10%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              216 (I)          216 (I)          ---              216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.154N         P=0.009 **       P=0.234          (e)              P=0.500          P=0.500         | 
|POLY 3             |        P=0.087N         P<0.001 **       P=0.068          (e)              P=0.161          P=0.161         | 
|POLY 1.5           |        P=0.090N         P<0.001 **       P=0.079          (e)              P=0.190          P=0.190         | 
|POLY 6             |        P=0.085N         P<0.001 **       P=0.067          (e)              P=0.159          P=0.159         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.152N         P=0.005 **       P=0.237          (e)              P=0.500          P=0.500         | 
|ORDER RESTRICTED   |        P=0.083          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       8/10 (80%)      | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           0/0.10           2/2.08           8/8.02          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             96.1%            99.8%           | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       8/10 (80%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.234          P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.068          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.079          P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.067          P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.237          P<0.001 **      | 
|ORDER RESTRICTED   |        P=0.014 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/10 (50%)       4/10 (40%)       3/10 (30%)       3/10 (30%)       3/10 (30%)       1/10 (10%)      | 
|POLY-3 RATE (b)    |        5/5.05           4/4.06           3/3.07           3/3.07           3/3.07           1/1.09          | 
|POLY-3 PERCENT (g) |        99.0%            98.5%            97.7%            97.7%            97.7%            91.7%           | 
|INT SACRIFICE 1 (c)|        5/10 (50%)       4/10 (40%)       3/10 (30%)       3/10 (30%)       3/10 (30%)       1/10 (10%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          216 (I)          216 (I)          216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.059N         P=0.500N         P=0.328N         P=0.328N         P=0.328N         P=0.077N        | 
|POLY 3             |        P=0.049N*        P=0.407N         P=0.235N         P=0.235N         P=0.235N         P=0.023N*       | 
|POLY 1.5           |        P=0.050N         P=0.415N         P=0.244N         P=0.244N         P=0.244N         P=0.026N*       | 
|POLY 6             |        P=0.049N*        P=0.407N         P=0.234N         P=0.234N         P=0.234N         P=0.023N*       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.057N         P=0.500N         P=0.325N         P=0.325N         P=0.325N         P=0.070N        | 
|ORDER RESTRICTED   |        P=0.074N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiofibrosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       0/10 (0%)        0/10 (0%)        2/10 (20%)       2/10 (20%)       1/10 (10%)      | 
|POLY-3 RATE (b)    |        1/1.09           0/0.10           0/0.10           2/2.08           2/2.08           1/1.09          | 
|POLY-3 PERCENT (g) |        91.7%            0.0%             0.0%             96.1%            96.1%            91.7%           | 
|INT SACRIFICE 1 (c)|        1/10 (10%)       0/10 (0%)        0/10 (0%)        2/10 (20%)       2/10 (20%)       1/10 (10%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          ---              ---              216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.274          P=0.500N         P=0.500N         P=0.500          P=0.500          P=0.766         | 
|POLY 3             |        P=0.218          P=0.161N         P=0.161N         P=0.301          P=0.301          P=0.531         | 
|POLY 1.5           |        P=0.223          P=0.190N         P=0.190N         P=0.320          P=0.320          P=0.554         | 
|POLY 6             |        P=0.218          P=0.159N         P=0.159N         P=0.299          P=0.299          P=0.529         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.272          P=0.500N         P=0.500N         P=0.500          P=0.500          P=0.763N        | 
|ORDER RESTRICTED   |        P=0.098          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        7/10 (70%)       5/10 (50%)      | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           0/0.10           7/7.03           5/5.05          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             99.6%            99.0%           | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        7/10 (70%)       5/10 (50%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.003 **       P=0.022 *       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P=0.002 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.002 **       P=0.016 *       | 
|ORDER RESTRICTED   |        P=0.016 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       8/10 (80%)       9/10 (90%)      | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           3/3.07           8/8.02           9/9.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             97.7%            99.8%            99.9%           | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       8/10 (80%)       9/10 (90%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.111          P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.025 *        P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.030 *        P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.025 *        P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.105          P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           0/0.10           1/1.09           4/4.06          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             91.7%            98.5%           | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       4/10 (40%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.051         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.161          P=0.007 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.190          P=0.009 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.159          P=0.007 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.043 *       | 
|ORDER RESTRICTED   |        P=0.211          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)    | 
|POLY-3 RATE (b)    |        10/10.00         10/10.00         10/10.00         10/10.00         10/10.00         10/10.00        | 
|POLY-3 PERCENT (g) |        100.0%           100.0%           100.0%           100.0%           100.0%           100.0%          | 
|INT SACRIFICE 1 (c)|        10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)    | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          216 (I)          216 (I)          216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/10 (50%)       8/10 (80%)       2/10 (20%)       6/10 (60%)       0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        5/5.05           8/8.02           2/2.08           6/6.04           0/0.10           0/0.10          | 
|POLY-3 PERCENT (g) |        99.0%            99.8%            96.1%            99.3%            0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        5/10 (50%)       8/10 (80%)       2/10 (20%)       6/10 (60%)       0/10 (0%)        0/10 (0%)       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          216 (I)          216 (I)          216 (I)          ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.180          P=0.180N         P=0.500          P=0.022N*        P=0.022N*       | 
|POLY 3             |        P<0.001N**       P=0.130          P=0.099N         P=0.424          P<0.001N**       P<0.001N**      | 
|POLY 1.5           |        P<0.001N**       P=0.134          P=0.106N         P=0.431          P=0.002N**       P=0.002N**      | 
|POLY 6             |        P<0.001N**       P=0.130          P=0.099N         P=0.425          P<0.001N**       P<0.001N**      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.175          P=0.175N         P=0.500          P=0.016N*        P=0.016N*       | 
|ORDER RESTRICTED   |        P=0.003N**       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       1/10 (10%)       1/10 (10%)       0/10 (0%)        2/10 (20%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        1/1.09           1/1.09           1/1.09           0/0.10           2/2.08           0/0.10          | 
|POLY-3 PERCENT (g) |        91.7%            91.7%            91.7%            0.0%             96.1%            0.0%            | 
|INT SACRIFICE 1 (c)|        1/10 (10%)       1/10 (10%)       1/10 (10%)       0/10 (0%)        2/10 (20%)       0/10 (0%)       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          216 (I)          216 (I)          ---              216 (I)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.457N         P=0.766          P=0.766          P=0.500N         P=0.500          P=0.500N        | 
|POLY 3             |        P=0.375N         P=0.531          P=0.531          P=0.161N         P=0.301          P=0.161N        | 
|POLY 1.5           |        P=0.383N         P=0.554          P=0.554          P=0.190N         P=0.320          P=0.190N        | 
|POLY 6             |        P=0.374N         P=0.529          P=0.529          P=0.159N         P=0.299          P=0.159N        | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.456N         P=0.763N         P=0.763N         P=0.500N         P=0.500          P=0.500N        | 
|ORDER RESTRICTED   |        P=0.308N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       4/10 (40%)       9/10 (90%)       10/10 (100%)     10/10 (100%)     10/10 (100%)    | 
|POLY-3 RATE (b)    |        2/2.08           4/4.06           9/9.01           10/10.00         10/10.00         10/10.00        | 
|POLY-3 PERCENT (g) |        96.1%            98.5%            99.9%            100.0%           100.0%           100.0%          | 
|INT SACRIFICE 1 (c)|        2/10 (20%)       4/10 (40%)       9/10 (90%)       10/10 (100%)     10/10 (100%)     10/10 (100%)    | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          216 (I)          216 (I)          216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.317          P=0.004 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.204          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.214          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.203          P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.314          P=0.003 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Toxic Hepatopathy                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       10/10 (100%)     10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           3/3.07           10/10.00         10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             97.7%            100.0%           100.0%          | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       10/10 (100%)     10/10 (100%)    | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.111          P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.025 *        P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.030 *        P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.025 *        P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.105          P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       10/10 (100%)     10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           1/1.09           10/10.00         10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             91.7%            100.0%           100.0%          | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       10/10 (100%)     10/10 (100%)    | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.500          P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.161          P<0.001 **       P<0.001N**      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.190          P<0.001 **       P<0.001N**      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.159          P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.500          P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       10/10 (100%)     10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           3/3.07           10/10.00         10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             97.7%            100.0%           100.0%          | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       10/10 (100%)     10/10 (100%)    | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.111          P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.025 *        P<0.001N**       P<0.001N**      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.030 *        P<0.001N**       P<0.001N**      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.025 *        P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.105          P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        2/10 (20%)       4/10 (40%)       8/10 (80%)       10/10 (100%)     10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/0.10           2/2.08           4/4.06           8/8.02           10/10.00         10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             96.1%            98.5%            99.8%            100.0%           100.0%          | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        2/10 (20%)       4/10 (40%)       8/10 (80%)       10/10 (100%)     10/10 (100%)    | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              216 (I)          216 (I)          216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.234          P=0.051          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.068          P=0.007 **       P<0.001 **       P<0.001 **       P<0.001N**      | 
|POLY 1.5           |        P<0.001 **       P=0.079          P=0.009 **       P<0.001 **       P<0.001 **       P<0.001N**      | 
|POLY 6             |        P<0.001 **       P=0.067          P=0.007 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.237          P=0.043 *        P<0.001 **       P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Multinucleated                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       10/10 (100%)     10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           3/3.07           10/10.00         10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             97.7%            100.0%           100.0%          | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       10/10 (100%)     10/10 (100%)    | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.111          P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.025 *        P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.030 *        P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.025 *        P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.105          P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Oval Cell                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        8/10 (80%)       10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           0/0.10           8/8.02           10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             99.8%            100.0%          | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        8/10 (80%)       10/10 (100%)    | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001N**      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001N**      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           0/0.10           1/1.09           4/4.06          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             91.7%            98.5%           | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       4/10 (40%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.051         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.161          P=0.007 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.190          P=0.009 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.159          P=0.007 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.043 *       | 
|ORDER RESTRICTED   |        P=0.211          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       0/10 (0%)        0/10 (0%)        1/10 (10%)       1/10 (10%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        2/2.08           0/0.10           0/0.10           1/1.09           1/1.09           0/0.10          | 
|POLY-3 PERCENT (g) |        96.1%            0.0%             0.0%             91.7%            91.7%            0.0%            | 
|INT SACRIFICE 1 (c)|        2/10 (20%)       0/10 (0%)        0/10 (0%)        1/10 (10%)       1/10 (10%)       0/10 (0%)       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          ---              ---              216 (I)          216 (I)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.362N         P=0.234N         P=0.234N         P=0.500N         P=0.500N         P=0.234N        | 
|POLY 3             |        P=0.273N         P=0.068N         P=0.068N         P=0.301N         P=0.301N         P=0.068N        | 
|POLY 1.5           |        P=0.281N         P=0.079N         P=0.079N         P=0.320N         P=0.320N         P=0.079N        | 
|POLY 6             |        P=0.272N         P=0.067N         P=0.067N         P=0.299N         P=0.299N         P=0.067N        | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.361N         P=0.237N         P=0.237N         P=0.500N         P=0.500N         P=0.237N        | 
|ORDER RESTRICTED   |        P=0.321N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       2/10 (20%)       4/10 (40%)       2/10 (20%)       5/10 (50%)       2/10 (20%)      | 
|POLY-3 RATE (b)    |        3/3.07           2/2.08           4/4.06           2/2.08           5/5.05           2/2.08          | 
|POLY-3 PERCENT (g) |        97.7%            96.1%            98.5%            96.1%            99.0%            96.1%           | 
|INT SACRIFICE 1 (c)|        3/10 (30%)       2/10 (20%)       4/10 (40%)       2/10 (20%)       5/10 (50%)       2/10 (20%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          216 (I)          216 (I)          216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.548          P=0.500N         P=0.500          P=0.500N         P=0.328          P=0.500N        | 
|POLY 3             |        P=0.512          P=0.354N         P=0.385          P=0.354N         P=0.235          P=0.354N        | 
|POLY 1.5           |        P=0.516          P=0.368N         P=0.396          P=0.368N         P=0.244          P=0.368N        | 
|POLY 6             |        P=0.512          P=0.353N         P=0.385          P=0.353N         P=0.234          P=0.353N        | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.549          P=0.500N         P=0.500          P=0.500N         P=0.325          P=0.500N        | 
|ORDER RESTRICTED   |        P=0.482N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       2/10 (20%)       2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           1/1.09           2/2.08           2/2.08          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             91.7%            96.1%            96.1%           | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       2/10 (20%)       2/10 (20%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.020 *        (e)              (e)              P=0.500          P=0.234          P=0.234         | 
|POLY 3             |        P=0.011 *        (e)              (e)              P=0.161          P=0.068          P=0.068         | 
|POLY 1.5           |        P=0.012 *        (e)              (e)              P=0.190          P=0.079          P=0.079         | 
|POLY 6             |        P=0.011 *        (e)              (e)              P=0.159          P=0.067          P=0.067         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.019 *        (e)              (e)              P=0.500          P=0.237          P=0.237         | 
|ORDER RESTRICTED   |        P=0.274          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia Bronchiolar                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       3/10 (30%)      | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           0/0.10           3/3.07           3/3.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             97.7%            97.7%           | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)       3/10 (30%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.111          P=0.111         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.025 *        P=0.025 *       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.030 *        P=0.030 *       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.025 *        P=0.025 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.105          P=0.105         | 
|ORDER RESTRICTED   |        P=0.197          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|POLY-3 RATE (b)    |        2/2.08           0/0.00           0/0.00           0/0.00           0/0.00           0/0.10          | 
|POLY-3 PERCENT (g) |        96.1%            0.0%             0.0%             0.0%             0.0%             0.0%            | 
|INT SACRIFICE 1 (c)|        2/10 (20%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.123N         P=1.000N         P=1.000          P=1.000N         P=1.000N         P=0.234N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.068N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.079N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.067N        | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.117N         P=1.000          P=1.000          P=1.000          P=1.000          P=0.237N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/10 (60%)       7/10 (70%)       7/10 (70%)       4/10 (40%)       1/10 (10%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        6/6.04           7/7.03           7/7.03           4/4.06           1/1.09           0/0.10          | 
|POLY-3 PERCENT (g) |        99.3%            99.6%            99.6%            98.5%            91.7%            0.0%            | 
|INT SACRIFICE 1 (c)|        6/10 (60%)       7/10 (70%)       7/10 (70%)       4/10 (40%)       1/10 (10%)       0/10 (0%)       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          216 (I)          216 (I)          216 (I)          216 (I)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.500          P=0.500          P=0.331N         P=0.034N*        P=0.009N**      | 
|POLY 3             |        P<0.001N**       P=0.439          P=0.439          P=0.254N         P=0.005N**       P<0.001N**      | 
|POLY 1.5           |        P<0.001N**       P=0.444          P=0.444          P=0.262N         P=0.006N**       P<0.001N**      | 
|POLY 6             |        P<0.001N**       P=0.440          P=0.440          P=0.254N         P=0.005N**       P<0.001N**      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.500          P=0.500          P=0.328N         P=0.029N*        P=0.005N**      | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           0/0.10           0/0.10           2/2.08          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             96.1%           | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.012 *        (e)              (e)              (e)              (e)              P=0.234         | 
|POLY 3             |        P=0.003 **       (e)              (e)              (e)              (e)              P=0.068         | 
|POLY 1.5           |        P=0.004 **       (e)              (e)              (e)              (e)              P=0.079         | 
|POLY 6             |        P=0.003 **       (e)              (e)              (e)              (e)              P=0.067         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        P=0.408          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           0/0.10           1/1.09           2/2.08          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             91.7%            96.1%           | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       2/10 (20%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.010 *        (e)              (e)              (e)              P=0.500          P=0.234         | 
|POLY 3             |        P=0.004 **       (e)              (e)              (e)              P=0.161          P=0.068         | 
|POLY 1.5           |        P=0.004 **       (e)              (e)              (e)              P=0.190          P=0.079         | 
|POLY 6             |        P=0.004 **       (e)              (e)              (e)              P=0.159          P=0.067         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.009 **       (e)              (e)              (e)              P=0.500          P=0.237         | 
|ORDER RESTRICTED   |        P=0.362          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       10/10 (100%)     10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/0.10           0/0.10           0/0.10           1/1.09           10/10.00         10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             91.7%            100.0%           100.0%          | 
|INT SACRIFICE 1 (c)|        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)       10/10 (100%)     10/10 (100%)    | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.500          P<0.001 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.161          P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.190          P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.159          P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.500          P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/10 (100%)     0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         10/10 (100%)    | 
|POLY-3 RATE (b)    |        10/10.00         0/0.00           0/0.00           0/0.00           0/0.00           10/10.00        | 
|POLY-3 PERCENT (g) |        100.0%           0.0%             0.0%             0.0%             0.0%             100.0%          | 
|INT SACRIFICE 1 (c)|        10/10 (100%)     0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         10/10 (100%)    | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          ---              ---              ---              ---              216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       2/10 (20%)       5/10 (50%)       9/9 (100%)       9/10 (90%)       6/6 (100%)      | 
|POLY-3 RATE (b)    |        3/3.07           2/2.08           5/5.05           9/9.00           9/9.01           6/6.00          | 
|POLY-3 PERCENT (g) |        97.7%            96.1%            99.0%            100.0%           99.9%            100.0%          | 
|INT SACRIFICE 1 (c)|        3/10 (30%)       2/10 (20%)       5/10 (50%)       9/9 (100%)       9/10 (90%)       6/6 (100%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          216 (I)          216 (I)          216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.500N         P=0.328          P=0.005 **       P=0.013 *        P=0.016 *       | 
|POLY 3             |        P<0.001 **       P=0.354N         P=0.235          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.368N         P=0.244          P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.353N         P=0.234          P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.325          P=0.002 **       P=0.010 *        P=0.010 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       3/10 (30%)       7/10 (70%)       7/10 (70%)       9/10 (90%)       7/10 (70%)      | 
|POLY-3 RATE (b)    |        3/3.07           3/3.07           7/7.03           7/7.03           9/9.01           7/7.03          | 
|POLY-3 PERCENT (g) |        97.7%            97.7%            99.6%            99.6%            99.9%            99.6%           | 
|INT SACRIFICE 1 (c)|        3/10 (30%)       3/10 (30%)       7/10 (70%)       7/10 (70%)       9/10 (90%)       7/10 (70%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          216 (I)          216 (I)          216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.024 *        P=0.683          P=0.095          P=0.095          P=0.013 *        P=0.095         | 
|POLY 3             |        P=0.015 *        P=0.557          P=0.047 *        P=0.047 *        P<0.001 **       P=0.047 *       | 
|POLY 1.5           |        P=0.015 *        P=0.569          P=0.050          P=0.050          P<0.001 **       P=0.050         | 
|POLY 6             |        P=0.015 *        P=0.557          P=0.047 *        P=0.047 *        P<0.001 **       P=0.047 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.023 *        P=0.686N         P=0.089          P=0.089          P=0.010 *        P=0.089         | 
|ORDER RESTRICTED   |        P=0.011 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/10 (50%)       6/10 (60%)       6/10 (60%)       4/10 (40%)       1/10 (10%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        5/5.05           6/6.04           6/6.04           4/4.06           1/1.09           0/0.10          | 
|POLY-3 PERCENT (g) |        99.0%            99.3%            99.3%            98.5%            91.7%            0.0%            | 
|INT SACRIFICE 1 (c)|        5/10 (50%)       6/10 (60%)       6/10 (60%)       4/10 (40%)       1/10 (10%)       0/10 (0%)       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          216 (I)          216 (I)          216 (I)          216 (I)          ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.500          P=0.500          P=0.500N         P=0.077N         P=0.022N*       | 
|POLY 3             |        P<0.001N**       P=0.424          P=0.424          P=0.407N         P=0.023N*        P<0.001N**      | 
|POLY 1.5           |        P<0.001N**       P=0.431          P=0.431          P=0.415N         P=0.026N*        P=0.002N**      | 
|POLY 6             |        P<0.001N**       P=0.425          P=0.425          P=0.407N         P=0.023N*        P<0.001N**      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.500          P=0.500          P=0.500N         P=0.070N         P=0.016N*       | 
|ORDER RESTRICTED   |        P=0.006N**       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/         4000 NG/        | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG           500 UG          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/10 (50%)       5/10 (50%)       6/10 (60%)       3/10 (30%)       1/10 (10%)       1/10 (10%)      | 
|POLY-3 RATE (b)    |        5/5.05           5/5.05           6/6.04           3/3.07           1/1.09           1/1.09          | 
|POLY-3 PERCENT (g) |        99.0%            99.0%            99.3%            97.7%            91.7%            91.7%           | 
|INT SACRIFICE 1 (c)|        5/10 (50%)       5/10 (50%)       6/10 (60%)       3/10 (30%)       1/10 (10%)       1/10 (10%)      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        216 (I)          216 (I)          216 (I)          216 (I)          216 (I)          216 (I)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003N**       P=0.669          P=0.500          P=0.328N         P=0.077N         P=0.077N        | 
|POLY 3             |        P<0.001N**       P=0.586          P=0.424          P=0.235N         P=0.023N*        P=0.023N*       | 
|POLY 1.5           |        P<0.001N**       P=0.593          P=0.431          P=0.244N         P=0.026N*        P=0.026N*       | 
|POLY 6             |        P<0.001N**       P=0.586          P=0.425          P=0.234N         P=0.023N*        P=0.023N*       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.003N**       P=0.672N         P=0.500          P=0.325N         P=0.070N         P=0.070N        | 
|ORDER RESTRICTED   |        P=0.038N*        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).