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TDMS Study 96022-02 Pathology Tables

NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04
Route: GAVAGE                                                                                                     Time: 13:24:40

                                                      53 WEEK SSAC/FINAL#1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFPCBMIX

       Lock Date:  11/04/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     10/12/00 - 10/13/00

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 002    80 NG  /10 UG
                               Include 003    240 NG /30 UG
                               Include 004    800 NG /100 UG
                               Include 005    2400 NG/300 UG
                               Include 006    4000 NG/500 UG





























a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:24:40    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/        
                                                   0 UG         10 UG        30 UG        100 UG       300 UG       500 UG          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           86           98           86           98           86           
                                                                                                                                    
  Scheduled Sacrifice                                 13           12           13           13           13                        
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                     8            7            8            8            8                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (7)          (8)          (8)          (8)                       
      Angiectasis                                                                                          1 (13%)                  
      Basophilic Focus                                 2 (25%)      3 (43%)      1 (13%)      1 (13%)      1 (13%)                  
      Cholangiofibrosis                                                                       2 (25%)      5 (63%)                  
      Clear Cell Focus, Multiple                                                 1 (13%)                                            
      Eosinophilic Focus                               1 (13%)                   1 (13%)                                            
      Fatty Change, Diffuse                                                                   4 (50%)      8 (100%)                 
      Fatty Change, Focal                              1 (13%)                                                                      
      Hepatodiaphragmatic Nodule                                                              1 (13%)                               
      Hyperplasia, Nodular                                                                    1 (13%)      8 (100%)                 
      Inflammation                                     7 (88%)      7 (100%)     8 (100%)     8 (100%)     8 (100%)                 
      Mixed Cell Focus                                 2 (25%)      2 (29%)      2 (25%)                                            
      Mixed Cell Focus, Multiple                       5 (63%)      3 (43%)      5 (63%)      7 (88%)                               
      Necrosis                                         1 (13%)      1 (14%)      3 (38%)      2 (25%)      2 (25%)                  
      Pigmentation                                                  5 (71%)      8 (100%)     8 (100%)     8 (100%)                 
      Toxic Hepatopathy                                                          2 (25%)      8 (100%)     8 (100%)                 
      Bile Duct, Cyst                                                                                      1 (13%)                  
      Bile Duct, Fibrosis                                                                                  1 (13%)                  
      Bile Duct, Hyperplasia                                                     1 (13%)      1 (13%)      8 (100%)                 
      Centrilobular, Fibrosis                                                                 5 (63%)      8 (100%)                 
      Hepatocyte, Hypertrophy                                       1 (14%)      2 (25%)      8 (100%)     8 (100%)                 
      Hepatocyte, Multinucleated                                                 3 (38%)      8 (100%)     8 (100%)                 
      Oval Cell, Hyperplasia                                                                               8 (100%)                 
      Portal, Fibrosis                                                                                     8 (100%)                 
   Pancreas                                           (8)          (7)          (8)          (8)          (8)                       
      Inflammation, Chronic Active                                               1 (13%)      2 (25%)      1 (13%)                  
      Acinus, Atrophy                                               1 (14%)      1 (13%)      1 (13%)      1 (13%)                  
      Acinus, Vacuolization Cytoplasmic                                                       6 (75%)      8 (100%)                 
   Stomach, Forestomach                               (8)                                                 (8)                       
      Edema                                                                                                1 (13%)                  
   Stomach, Glandular                                 (8)                                                 (8)                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:24:40    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/        
                                                   0 UG         10 UG        30 UG        100 UG       300 UG       500 UG          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Erosion                                                                                              2 (25%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (8)          (7)          (8)          (8)          (8)                       
      Angiectasis                                                   2 (29%)      3 (38%)      4 (50%)      1 (13%)                  
      Atrophy                                                                                              5 (63%)                  
      Degeneration, Cystic                                                       1 (13%)      2 (25%)                               
      Hyperplasia                                                                1 (13%)      1 (13%)      1 (13%)                  
      Hypertrophy                                      5 (63%)      3 (43%)      6 (75%)      7 (88%)      5 (63%)                  
      Vacuolization Cytoplasmic                        1 (13%)      1 (14%)      1 (13%)      1 (13%)                               
   Pituitary Gland                                    (8)                                                 (8)                       
      Cyst                                                                                                 1 (13%)                  
   Thyroid Gland                                      (8)          (7)          (8)          (8)          (8)                       
      C-Cell, Hyperplasia                              1 (13%)                                             1 (13%)                  
      Follicular Cell, Hypertrophy                     3 (38%)      4 (57%)      6 (75%)      7 (88%)      7 (88%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (8)          (7)          (8)          (8)          (8)                       
      Atrophy                                          7 (88%)      6 (86%)      6 (75%)      5 (63%)                               
      Cyst                                                          1 (14%)                                                         
   Uterus                                             (8)          (7)          (8)          (8)          (8)                       
      Inflammation, Suppurative                                                  2 (25%)                                            
      Metaplasia, Squamous                             6 (75%)      5 (71%)      5 (63%)      5 (63%)                               
      Endometrium, Hyperplasia, Cystic                 6 (75%)      6 (86%)      5 (63%)      5 (63%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (8)                                                 (8)                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:24:40    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/        
                                                   0 UG         10 UG        30 UG        100 UG       300 UG       500 UG          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                 1 (13%)                                                                      
      Pigmentation                                     8 (100%)                                            8 (100%)                 
   Thymus                                             (8)          (7)          (8)          (8)          (6)                       
      Atrophy                                          5 (63%)      7 (100%)     7 (88%)      8 (100%)     6 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (8)          (2)          (1)          (1)          (8)                       
      Cyst                                             1 (13%)                                                                      
      Hyperplasia                                      1 (13%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (8)          (7)          (8)          (8)          (8)                       
      Infiltration Cellular, Histiocyte                7 (88%)      5 (71%)      7 (88%)      6 (75%)      8 (100%)                 
      Inflammation                                                                            1 (13%)                               
      Pigmentation                                                                            1 (13%)                               
      Alveolar Epithelium, Hyperplasia                                                        1 (13%)                               
      Alveolar Epithelium, Metaplasia, Bronchiolar                               3 (38%)      3 (38%)      6 (75%)                  
      Interstitium, Fibrosis                                                                  1 (13%)                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
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