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TDMS Study 96022-02 Pathology Tables

NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04
Route: GAVAGE                                                                                                     Time: 13:39:15

                                                      53 WEEK SSAC/FINAL#1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFPCBMIX

       Lock Date:  11/04/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     10/12/00 - 10/13/00

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 002    80 NG  /10 UG
                               Include 003    240 NG /30 UG
                               Include 004    800 NG /100 UG
                               Include 005    2400 NG/300 UG
                               Include 006    4000 NG/500 UG































                                                              Page   1


NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG /                                 | 0| 2| 4| 6| 8| 8| 8| 8| 8| 8| 8| 9| 9|                                   |      L     |
    0 UG                                   | 1| 2| 2| 3| 1| 2| 3| 4| 6| 7| 9| 0| 4|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |             +  +  +  +  +  +  +  +                                       |   8        |
      Basophilic Focus                     |                            X  X                                          |      2     |
      Eosinophilic Focus                   |                X                                                         |      1     |
      Fatty Change, Focal                  |                               1                                          |      1  1.0|
      Inflammation                         |             1  1  1  1  1  1  1                                          |      7  1.0|
      Mixed Cell Focus                     |                               X  X                                       |      2     |
      Mixed Cell Focus, Multiple           |             X     X  X  X  X                                             |      5     |
      Necrosis                             |                1                                                         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |             +  +  +  +  +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |             +  +  +  +  +  +  +  +                                       |   8        |
      Hypertrophy                          |             1  1  1  1  1                                                |      5  1.0|
      Vacuolization Cytoplasmic            |             1                                                            |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |             +  +  +  +  +  +  +  +                                       |   8        |
      C-Cell, Hyperplasia                  |                   1                                                      |      1  1.0|
      Follicular Cell, Hypertrophy         |                1     1  1                                                |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG /                                 | 0| 2| 4| 6| 8| 8| 8| 8| 8| 8| 8| 9| 9|                                   |      L     |
    0 UG                                   | 1| 2| 2| 3| 1| 2| 3| 4| 6| 7| 9| 0| 4|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |             +  +  +  +  +  +  +  +                                       |   8        |
      Atrophy                              |             3  3  3  3  3  3  3                                          |      7  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |             +  +  +  +  +  +  +  +                                       |   8        |
      Metaplasia, Squamous                 |             2  2  2  2     1  2                                          |      6  1.8|
      Endometrium, Hyperplasia, Cystic     |             2  2  2  3     1  2                                          |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |             +  +  +  +  +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |             +  +  +  +  +  +  +  +                                       |   8        |
      Hematopoietic Cell Proliferation     |                   1                                                      |      1  1.0|
      Pigmentation                         |             2  1  2  2  1  2  1  1                                       |      8  1.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |             +  +  +  +  +  +  +  +                                       |   8        |
      Atrophy                              |             2  2  2     2  2                                             |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |             +  +  +  +  +  +  +  +                                       |   8        |
      Cyst                                 |                                  3                                       |      1  3.0|
      Hyperplasia                          |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |             +  +  +  +  +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG /                                 | 0| 2| 4| 6| 8| 8| 8| 8| 8| 8| 8| 9| 9|                                   |      L     |
    0 UG                                   | 1| 2| 2| 3| 1| 2| 3| 4| 6| 7| 9| 0| 4|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Infiltration Cellular, Histiocyte    |             1  1  1     1  1  2  1                                       |      7  1.1|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                      |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                      |            |
                                           | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      A     |
    80 NG  /                               | 2| 5| 5| 6| 6| 7| 7| 7| 8| 8| 8| 8|                                      |      L     |
    10 UG                                  | 8| 5| 7| 1| 5| 6| 8| 9| 0| 4| 5| 6|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |                +  +  +  +  +  +  +                                       |   7        |
      Basophilic Focus                     |                X     X        X                                          |      3     |
      Inflammation                         |                2  1  1  1  1  1  1                                       |      7  1.1|
      Mixed Cell Focus                     |                         X  X                                             |      2     |
      Mixed Cell Focus, Multiple           |                X  X  X                                                   |      3     |
      Necrosis                             |                               1                                          |      1  1.0|
      Pigmentation                         |                      1  1  1  1  1                                       |      5  1.0|
      Hepatocyte, Hypertrophy              |                      1                                                   |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |                +  +  +  +  +  +  +                                       |   7        |
      Acinus, Atrophy                      |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |                +  +  +  +  +  +  +                                       |   7        |
      Angiectasis                          |                            1     1                                       |      2  1.0|
      Hypertrophy                          |                   2           1  3                                       |      3  2.0|
      Vacuolization Cytoplasmic            |                                  1                                       |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +  +  +  +  +                                       |   7        |
      Follicular Cell, Hypertrophy         |                   1        1  1  3                                       |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |                +  +  +  +  +  +  +                                       |   7        |
      Atrophy                              |                   3  2  3  3  3  3                                       |      6  2.8|
      Cyst                                 |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                      |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                      |            |
                                           | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5|                                      |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                      |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                      |      A     |
    80 NG  /                               | 2| 5| 5| 6| 6| 7| 7| 7| 8| 8| 8| 8|                                      |      L     |
    10 UG                                  | 8| 5| 7| 1| 5| 6| 8| 9| 0| 4| 5| 6|                                      |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  |                +  +  +  +  +  +  +                                       |   7        |
      Metaplasia, Squamous                 |                      2  2  2  1  1                                       |      5  1.6|
      Endometrium, Hyperplasia, Cystic     |                   1  2  2  2  1  2                                       |      6  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |                +  +  +  +  +  +  +                                       |   7        |
      Atrophy                              |                2  2  2  2  3  1  2                                       |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |                   +  +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |                +  +  +  +  +  +  +                                       |   7        |
      Infiltration Cellular, Histiocyte    |                1     2     1  1  1                                       |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                   |      A     |
    240 NG /                               | 0| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 5| 5|                                   |      L     |
    30 UG                                  | 2| 8| 1| 2| 3| 4| 5| 2| 6| 7| 9| 4| 9|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +     +  +  +                                          |   8        |
      Basophilic Focus                     |       X                                                                  |      1     |
      Clear Cell Focus, Multiple           |             X                                                            |      1     |
      Eosinophilic Focus                   |                         X                                                |      1     |
      Inflammation                         |       1  2  2  1  1     1  2  1                                          |      8  1.4|
      Mixed Cell Focus                     |                            X  X                                          |      2     |
      Mixed Cell Focus, Multiple           |       X  X  X  X        X                                                |      5     |
      Necrosis                             |          1  1                 1                                          |      3  1.0|
      Pigmentation                         |       1  1  1  2  1     1  1  1                                          |      8  1.1|
      Toxic Hepatopathy                    |          1              1                                                |      2  1.0|
      Bile Duct, Hyperplasia               |          1                                                               |      1  1.0|
      Hepatocyte, Hypertrophy              |          2              1                                                |      2  1.5|
      Hepatocyte, Multinucleated           |          1  1                 1                                          |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +  +     +  +  +                                          |   8        |
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
      Acinus, Atrophy                      |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +  +  +     +  +  +                                          |   8        |
      Angiectasis                          |             1           1     1                                          |      3  1.0|
      Degeneration, Cystic                 |                               2                                          |      1  2.0|
      Hyperplasia                          |                               2                                          |      1  2.0|
      Hypertrophy                          |       1  2  2  2        2  2                                             |      6  1.8|
      Vacuolization Cytoplasmic            |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |       +                                                                  |   1        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +  +     +  +  +                                          |   8        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                   |      A     |
    240 NG /                               | 0| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 5| 5|                                   |      L     |
    30 UG                                  | 2| 8| 1| 2| 3| 4| 5| 2| 6| 7| 9| 4| 9|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Follicular Cell, Hypertrophy         |          1  1  1  1     1     1                                          |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +  +     +  +  +                                          |   8        |
      Atrophy                              |       3        3  3     3  3  3                                          |      6  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +     +  +  +                                          |   8        |
      Inflammation, Suppurative            |                2        1                                                |      2  1.5|
      Metaplasia, Squamous                 |       1        2  3        2  2                                          |      5  2.0|
      Endometrium, Hyperplasia, Cystic     |                4  3     4  1  3                                          |      5  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +  +     +  +  +                                          |   8        |
      Atrophy                              |          2  3  2  2     2  2  2                                          |      7  2.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +  +     +  +  +                                          |   8        |
      Infiltration Cellular, Histiocyte    |          1  1  1  1     1  1  1                                          |      7  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 6| 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                   |      A     |
    240 NG /                               | 0| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 5| 5|                                   |      L     |
    30 UG                                  | 2| 8| 1| 2| 3| 4| 5| 2| 6| 7| 9| 4| 9|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |       1        2           1                                             |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |      A     |
    800 NG /                               | 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 6|                                   |      L     |
    100 UG                                 | 6| 7| 8| 0| 5| 0| 5| 6| 7| 9| 0| 1| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +           +  +  +  +                                          |   8        |
      Basophilic Focus                     |          X                                                               |      1     |
      Cholangiofibrosis                    | 1                       2                                                |      2  1.5|
      Fatty Change, Diffuse                | 1     1              1        1                                          |      4  1.0|
      Hepatodiaphragmatic Nodule           |       X                                                                  |      1     |
      Hyperplasia, Nodular                 |                            X                                             |      1     |
      Inflammation                         | 2  2  2  2           2  2  2  1                                          |      8  1.9|
      Mixed Cell Focus, Multiple           | X  X  X  X           X  X  X                                             |      7     |
      Necrosis                             | 1     1                                                                  |      2  1.0|
      Pigmentation                         | 2  2  2  2           2  2  2  2                                          |      8  2.0|
      Toxic Hepatopathy                    | 1  1  1  1           1  1  2  2                                          |      8  1.3|
      Bile Duct, Hyperplasia               |                               1                                          |      1  1.0|
      Centrilobular, Fibrosis              | 1  1                    1  1  2                                          |      5  1.2|
      Hepatocyte, Hypertrophy              | 1  2  1  1           2  1  3  2                                          |      8  1.6|
      Hepatocyte, Multinucleated           | 1  2  2  1           1  1  2  1                                          |      8  1.4|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +           +  +  +  +                                          |   8        |
      Inflammation, Chronic Active         |          1                 1                                             |      2  1.0|
      Acinus, Atrophy                      |          1                                                               |      1  1.0|
      Acinus, Vacuolization Cytoplasmic    | 1  1  1  1              1     1                                          |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +           +  +  +  +                                          |   8        |
      Angiectasis                          | 1        2              1     1                                          |      4  1.3|
      Degeneration, Cystic                 |       1  2                                                               |      2  1.5|
      Hyperplasia                          |          2                                                               |      1  2.0|
      Hypertrophy                          | 1  3  2  3              3  2  1                                          |      7  2.1|
      Vacuolization Cytoplasmic            |                               1                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |      A     |
    800 NG /                               | 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 6|                                   |      L     |
    100 UG                                 | 6| 7| 8| 0| 5| 0| 5| 6| 7| 9| 0| 1| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Thyroid Gland                           | +  +  +  +           +  +  +  +                                          |   8        |
      Follicular Cell, Hypertrophy         | 2  1  1  2           1  2     1                                          |      7  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +           +  +  +  +                                          |   8        |
      Atrophy                              |       3  3           3  3  3                                             |      5  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +           +  +  +  +                                          |   8        |
      Metaplasia, Squamous                 |       2  2           2  2  1                                             |      5  1.8|
      Endometrium, Hyperplasia, Cystic     |       2  2           2  2  1                                             |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +           +  +  +  +                                          |   8        |
      Atrophy                              | 3  3  3  2           3  4  3  3                                          |      8  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +           +  +  +  +                                          |   8        |
      Infiltration Cellular, Histiocyte    | 1  1     1              1  2  2                                          |      6  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 6| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |      A     |
    800 NG /                               | 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 6|                                   |      L     |
    100 UG                                 | 6| 7| 8| 0| 5| 0| 5| 6| 7| 9| 0| 1| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Inflammation                         |                            2                                             |      1  2.0|
      Pigmentation                         |                            2                                             |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                               2                                          |      1  2.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 1                          3  3                                          |      3  2.3|
      Interstitium, Fibrosis               |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 5| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    2400 NG/                               | 2| 2| 2| 2| 3| 3| 5| 6| 7| 8| 8| 8| 8|                                   |      L     |
    300 UG                                 | 6| 7| 8| 9| 0| 8| 3| 0| 9| 1| 2| 5| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +              +  +  +                                       |   8        |
      Angiectasis                          |       2                                                                  |      1  2.0|
      Basophilic Focus                     |       X                                                                  |      1     |
      Cholangiofibrosis                    |    3  2  3                 3  1                                          |      5  2.4|
      Fatty Change, Diffuse                | 2  2  2  3  2              2  2  2                                       |      8  2.1|
      Hyperplasia, Nodular                 | X  X  X  X  X              X  X  X                                       |      8     |
      Inflammation                         | 2  1  1  1  2              1  1  2                                       |      8  1.4|
      Necrosis                             | 1                                1                                       |      2  1.0|
      Pigmentation                         | 2  3  2  3  3              2  3  2                                       |      8  2.5|
      Toxic Hepatopathy                    | 3  4  3  3  3              3  3  3                                       |      8  3.1|
      Bile Duct, Cyst                      |                            2                                             |      1  2.0|
      Bile Duct, Fibrosis                  |          1                                                               |      1  1.0|
      Bile Duct, Hyperplasia               | 2  2  3  2  2              2  2  2                                       |      8  2.1|
      Centrilobular, Fibrosis              | 2  2  2  2  2              2  2  2                                       |      8  2.0|
      Hepatocyte, Hypertrophy              | 4  4  4  4  3              4  4  3                                       |      8  3.8|
      Hepatocyte, Multinucleated           | 3  3  2  3  3              2  3  2                                       |      8  2.6|
      Oval Cell, Hyperplasia               | 3  3  3  3  2              2  2  3                                       |      8  2.6|
      Portal, Fibrosis                     | 2  2  2  2  2              2  2  2                                       |      8  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +              +  +  +                                       |   8        |
      Inflammation, Chronic Active         | 1                                                                        |      1  1.0|
      Acinus, Atrophy                      | 1                                                                        |      1  1.0|
      Acinus, Vacuolization Cytoplasmic    | 2  2  1  2  2              2  2  1                                       |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +              +  +  +                                       |   8        |
      Edema                                |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +              +  +  +                                       |   8        |
      Erosion                              | 1                                2                                       |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 5| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    2400 NG/                               | 2| 2| 2| 2| 3| 3| 5| 6| 7| 8| 8| 8| 8|                                   |      L     |
    300 UG                                 | 6| 7| 8| 9| 0| 8| 3| 0| 9| 1| 2| 5| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +              +  +  +                                       |   8        |
      Angiectasis                          |                                  1                                       |      1  1.0|
      Atrophy                              | 2  3  2  2                    2                                          |      5  2.2|
      Hyperplasia                          |                                  2                                       |      1  2.0|
      Hypertrophy                          |    1  1  1                    1  1                                       |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +              +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +              +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +              +  +  +                                       |   8        |
      Cyst                                 |             1                                                            |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +              +  +  +                                       |   8        |
      C-Cell, Hyperplasia                  |                               1                                          |      1  1.0|
      Follicular Cell, Hypertrophy         | 1  3  2  1  1              1  2                                          |      7  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +              +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +              +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +              +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +              +  +  +                                       |   8        |
      Pigmentation                         | 1  1  1  1  2              1  2  1                                       |      8  1.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96022-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                            TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                       Date: 04/27/04    
Route: GAVAGE                                                                                                     Time: 13:39:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 5| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    2400 NG/                               | 2| 2| 2| 2| 3| 3| 5| 6| 7| 8| 8| 8| 8|                                   |      L     |
    300 UG                                 | 6| 7| 8| 9| 0| 8| 3| 0| 9| 1| 2| 5| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  | +  +  +  M  +              M  +  +                                       |   6        |
      Atrophy                              | 4  3  4     4                 4  4                                       |      6  3.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +              +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +              +  +  +                                       |   8        |
      Infiltration Cellular, Histiocyte    | 1  1  3  1  1              1  1  2                                       |      8  1.4|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 2  1  2                    2  1  2                                       |      6  1.7|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
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