https://ntp.niehs.nih.gov/go/19216

TDMS Study 96022-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 04/27/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 13:39:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
------------------------------------------------------------------------------------------------------------------------------------
                                                        53 WEEK SSAC/FINAL#1                                                        
               REASONS FOR REMOVAL:    25017 Scheduled Sacrifice                                                                    
               REMOVAL DATE RANGE:     101200 101300                                                                                
               TREATMENT GROUPS:       INCLUDE 001    0 NG /  0 UG                                                                  
                                       INCLUDE 002    80 NG  /10 UG                                                                 
                                       INCLUDE 003    240 NG /30 UG                                                                 
                                       INCLUDE 004    800 NG /100 UG                                                                
                                       INCLUDE 005    2400 NG/300 UG                                                                
                                       INCLUDE 006    4000 NG/500 UG                                                                
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 04/27/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 13:39:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF      TEF EVALUATION (PCB MIXTURE;PCB 126/P                                                                       
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Angiectasis                                                                                  
                                       Atrophy                                                                                      
Liver                                  Cholangiofibrosis                                                                            
                                       Fatty Change Diffuse                                                                         
                                       Hyperplasia                                                                                  
                                       Mixed Cell Focus                                                                             
                                       Pigmentation                                                                                 
                                       Toxic Hepatopathy                                                                            
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Centrilobular                   Fibrosis                                                                                     
Liver: Hepatocyte                      Hypertrophy                                                                                  
                                       Multinucleated                                                                               
Liver: Oval Cell                       Hyperplasia                                                                                  
Liver: Portal                          Fibrosis                                                                                     
Lung: Alveolar Epithelium              Metaplasia Bronchiolar                                                                       
Ovary                                  Atrophy                                                                                      
Pancreas: Acinus                       Vacuolization Cytoplasmic                                                                    
Thymus                                 Atrophy                                                                                      
Thyroid Gland: Follicular Cell         Hypertrophy                                                                                  
Uterus                                 Metaplasia                                                                                   
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P        
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         2/7 (29%)        3/8 (38%)        4/8 (50%)        1/8 (13%)                        | 
|POLY-3 RATE (b)    |        0/0.39           2/2.24           3/3.24           4/4.20           1/1.34                           | 
|POLY-3 PERCENT (g) |        0.0%             89.1%            92.5%            95.4%            74.6%                            | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         2/7 (28.6%)      3/8 (37.5%)      4/8 (50%)        1/8 (12.5%)                      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              365 (I)          365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.513N         P=0.202          P=0.107          P=0.047 *        P=0.500                          | 
|POLY 3             |        P=0.402N         P=0.052          P=0.022 *        P=0.005 **       P=0.173                          | 
|POLY 1.5           |        P=0.419N         P=0.073          P=0.031 *        P=0.007 **       P=0.228                          | 
|POLY 6             |        P=0.401N         P=0.048 *        P=0.020 *        P=0.004 **       P=0.159                          | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.513N         P=0.200          P=0.100          P=0.038 *        P=0.500                          | 
|ORDER RESTRICTED   |        P=0.062          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         0/8 (0%)         0/8 (0%)         5/8 (63%)                        | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           0/0.39           0/0.39           5/5.15                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             97.2%                            | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         0/8 (0%)         0/8 (0%)         5/8 (62.5%)                      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.018 *                        | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.013 *                        | 
|ORDER RESTRICTED   |        P=0.030 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         1/8 (13%)        2/8 (25%)        0/8 (0%)                         | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           1/1.34           2/2.29           0/0.39                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             74.6%            87.2%            0.0%                             | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         1/8 (12.5%)      2/8 (25%)        0/8 (0%)                         | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              365 (I)          365 (I)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.624N         (e)              P=0.500          P=0.232          (e)                              | 
|POLY 3             |        P=0.429N         (e)              P=0.173          P=0.069          (e)                              | 
|POLY 1.5           |        P=0.459N         (e)              P=0.228          P=0.093          (e)                              | 
|POLY 6             |        P=0.426N         (e)              P=0.159          P=0.064          (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.626N         (e)              P=0.500          P=0.233          (e)                              | 
|ORDER RESTRICTED   |        P=0.423          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/8 (63%)        3/7 (43%)        6/8 (75%)        7/8 (88%)        5/8 (63%)                        | 
|POLY-3 RATE (b)    |        5/5.15           3/3.20           6/6.10           7/7.05           5/5.15                           | 
|POLY-3 PERCENT (g) |        97.2%            93.9%            98.4%            99.3%            97.2%                            | 
|INT SACRIFICE 1 (c)|        5/8 (62.5%)      3/7 (42.9%)      6/8 (75%)        7/8 (87.5%)      5/8 (62.5%)                      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        365 (I)          365 (I)          365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.536          P=0.408N         P=0.500          P=0.288          P=0.691                          | 
|POLY 3             |        P=0.493          P=0.320N         P=0.439          P=0.237          P=0.623                          | 
|POLY 1.5           |        P=0.501          P=0.337N         P=0.450          P=0.247          P=0.634                          | 
|POLY 6             |        P=0.492          P=0.316N         P=0.437          P=0.235          P=0.621                          | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.536          P=0.405N         P=0.500          P=0.285          P=0.696N                         | 
|ORDER RESTRICTED   |        P=0.295          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/8 (25%)        3/7 (43%)        1/8 (13%)        1/8 (13%)        1/8 (13%)                        | 
|POLY-3 RATE (b)    |        2/2.29           3/3.20           1/1.34           1/1.34           1/1.34                           | 
|POLY-3 PERCENT (g) |        87.2%            93.9%            74.6%            74.6%            74.6%                            | 
|INT SACRIFICE 1 (c)|        2/8 (25%)        3/7 (42.9%)      1/8 (12.5%)      1/8 (12.5%)      1/8 (12.5%)                      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        365 (I)          365 (I)          365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.289N         P=0.430          P=0.500N         P=0.500N         P=0.500N                         | 
|POLY 3             |        P=0.201N         P=0.303          P=0.314N         P=0.314N         P=0.314N                         | 
|POLY 1.5           |        P=0.216N         P=0.327          P=0.348N         P=0.348N         P=0.348N                         | 
|POLY 6             |        P=0.197N         P=0.297          P=0.304N         P=0.304N         P=0.304N                         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.286N         P=0.427          P=0.500N         P=0.500N         P=0.500N                         | 
|ORDER RESTRICTED   |        P=0.354N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiofibrosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         0/8 (0%)         2/8 (25%)        5/8 (63%)                        | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           0/0.39           2/2.29           5/5.15                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             87.2%            97.2%                            | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         0/8 (0%)         2/8 (25%)        5/8 (62.5%)                      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.232          P=0.018 *                        | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.069          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.093          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.064          P<0.001 **                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.233          P=0.013 *                        | 
|ORDER RESTRICTED   |        P=0.038 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         0/8 (0%)         4/8 (50%)        8/8 (100%)                       | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           0/0.39           4/4.20           8/8.00                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             95.4%            100.0%                           | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         0/8 (0%)         4/8 (50%)        8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.047 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.005 **       P<0.001N**                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.007 **       P<0.001N**                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.004 **       P<0.001N**                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.038 *        P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         0/8 (0%)         1/8 (13%)        8/8 (100%)                       | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           0/0.39           1/1.34           8/8.00                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             74.6%            100.0%                           | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         0/8 (0%)         1/8 (12.5%)      8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.500          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.173          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.228          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.159          P<0.001 **                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.500          P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/8 (88%)        7/7 (100%)       8/8 (100%)       8/8 (100%)       8/8 (100%)                       | 
|POLY-3 RATE (b)    |        7/7.05           7/7.00           8/8.00           8/8.00           8/8.00                           | 
|POLY-3 PERCENT (g) |        99.3%            100.0%           100.0%           100.0%           100.0%                           | 
|INT SACRIFICE 1 (c)|        7/8 (87.5%)      7/7 (100%)       8/8 (100%)       8/8 (100%)       8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        365 (I)          365 (I)          365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.535          P=0.527          P=0.500          P=0.500          P=0.500                          | 
|POLY 3             |        P=0.539          P=0.505          P=0.476          P=0.476          P=0.476                          | 
|POLY 1.5           |        P=0.537          P=0.508          P=0.480          P=0.480          P=0.480                          | 
|POLY 6             |        P=0.542          P=0.506          P=0.478          P=0.478          P=0.478                          | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.536          P=0.533          P=0.500          P=0.500          P=0.500                          | 
|ORDER RESTRICTED   |        P=0.077          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/8 (88%)        5/7 (71%)        7/8 (88%)        7/8 (88%)        0/8 (0%)                         | 
|POLY-3 RATE (b)    |        7/7.05           5/5.10           7/7.05           7/7.05           0/0.39                           | 
|POLY-3 PERCENT (g) |        99.3%            98.1%            99.3%            99.3%            0.0%                             | 
|INT SACRIFICE 1 (c)|        7/8 (87.5%)      5/7 (71.4%)      7/8 (87.5%)      7/8 (87.5%)      0/8 (0%)                         | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        365 (I)          365 (I)          365 (I)          365 (I)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.450N         P=0.768          P=0.768          P=0.002N**                       | 
|POLY 3             |        P<0.001N**       P=0.401N         P=0.735          P=0.735          P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.410N         P=0.739          P=0.739          P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.400N         P=0.735          P=0.735          P<0.001N**                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.446N         P=0.767N         P=0.767N         P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/8 (13%)        1/7 (14%)        3/8 (38%)        2/8 (25%)        2/8 (25%)                        | 
|POLY-3 RATE (b)    |        1/1.34           1/1.29           3/3.24           2/2.29           2/2.29                           | 
|POLY-3 PERCENT (g) |        74.6%            77.4%            92.5%            87.2%            87.2%                            | 
|INT SACRIFICE 1 (c)|        1/8 (12.5%)      1/7 (14.3%)      3/8 (37.5%)      2/8 (25%)        2/8 (25%)                        | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        365 (I)          365 (I)          365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.513          P=0.738          P=0.288          P=0.500          P=0.500                          | 
|POLY 3             |        P=0.422          P=0.512          P=0.156          P=0.314          P=0.314                          | 
|POLY 1.5           |        P=0.438          P=0.555          P=0.180          P=0.348          P=0.348                          | 
|POLY 6             |        P=0.418          P=0.501          P=0.149          P=0.304          P=0.304                          | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.513          P=0.733          P=0.285          P=0.500          P=0.500                          | 
|ORDER RESTRICTED   |        P=0.386          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         5/7 (71%)        8/8 (100%)       8/8 (100%)       8/8 (100%)                       | 
|POLY-3 RATE (b)    |        0/0.39           5/5.10           8/8.00           8/8.00           8/8.00                           | 
|POLY-3 PERCENT (g) |        0.0%             98.1%            100.0%           100.0%           100.0%                           | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         5/7 (71.4%)      8/8 (100%)       8/8 (100%)       8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              365 (I)          365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       P=0.011 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P<0.001 **       P<0.001N**       P<0.001N**       P<0.001N**                       | 
|POLY 1.5           |        P<0.001 **       P<0.001 **       P<0.001N**       P<0.001N**       P<0.001N**                       | 
|POLY 6             |        P<0.001 **       P<0.001 **       P<0.001N**       P<0.001N**       P<0.001N**                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.005 **       P=0.007 **       P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Toxic Hepatopathy                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         2/8 (25%)        8/8 (100%)       8/8 (100%)                       | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           2/2.29           8/8.00           8/8.00                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             87.2%            100.0%           100.0%                           | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         2/8 (25%)        8/8 (100%)       8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.232          P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.069          P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.093          P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.064          P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.233          P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         1/8 (13%)        1/8 (13%)        8/8 (100%)                       | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           1/1.34           1/1.34           8/8.00                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             74.6%            74.6%            100.0%                           | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         1/8 (12.5%)      1/8 (12.5%)      8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.500          P=0.500          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.173          P=0.173          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.228          P=0.228          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.159          P=0.159          P<0.001 **                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.500          P=0.500          P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         0/8 (0%)         5/8 (63%)        8/8 (100%)                       | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           0/0.39           5/5.15           8/8.00                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             97.2%            100.0%                           | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         0/8 (0%)         5/8 (62.5%)      8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.018 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.013 *        P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         1/7 (14%)        2/8 (25%)        8/8 (100%)       8/8 (100%)                       | 
|POLY-3 RATE (b)    |        0/0.39           1/1.29           2/2.29           8/8.00           8/8.00                           | 
|POLY-3 PERCENT (g) |        0.0%             77.4%            87.2%            100.0%           100.0%                           | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         1/7 (14.3%)      2/8 (25%)        8/8 (100%)       8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              365 (I)          365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.473          P=0.232          P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.155          P=0.069          P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.208          P=0.093          P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.142          P=0.064          P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.467          P=0.233          P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Multinucleated                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         3/8 (38%)        8/8 (100%)       8/8 (100%)                       | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           3/3.24           8/8.00           8/8.00                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             92.5%            100.0%           100.0%                           | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         3/8 (37.5%)      8/8 (100%)       8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.107          P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.022 *        P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.031 *        P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.020 *        P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.100          P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Oval Cell                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         0/8 (0%)         0/8 (0%)         8/8 (100%)                       | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           0/0.39           0/0.39           8/8.00                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             100.0%                           | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         0/8 (0%)         0/8 (0%)         8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         0/8 (0%)         0/8 (0%)         8/8 (100%)                       | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           0/0.39           0/0.39           8/8.00                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             100.0%                           | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         0/8 (0%)         0/8 (0%)         8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/8 (88%)        5/7 (71%)        7/8 (88%)        6/8 (75%)        8/8 (100%)                       | 
|POLY-3 RATE (b)    |        7/7.05           5/5.10           7/7.05           6/6.10           8/8.00                           | 
|POLY-3 PERCENT (g) |        99.3%            98.1%            99.3%            98.4%            100.0%                           | 
|INT SACRIFICE 1 (c)|        7/8 (87.5%)      5/7 (71.4%)      7/8 (87.5%)      6/8 (75%)        8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        365 (I)          365 (I)          365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.229          P=0.450N         P=0.768          P=0.500N         P=0.500                          | 
|POLY 3             |        P=0.232          P=0.401N         P=0.735          P=0.456N         P=0.476                          | 
|POLY 1.5           |        P=0.233          P=0.410N         P=0.739          P=0.464N         P=0.480                          | 
|POLY 6             |        P=0.233          P=0.400N         P=0.735          P=0.456N         P=0.478                          | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.226          P=0.446N         P=0.767N         P=0.500N         P=0.500                          | 
|ORDER RESTRICTED   |        P=0.238          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia Bronchiolar                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         3/8 (38%)        3/8 (38%)        6/8 (75%)                        | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           3/3.24           3/3.24           6/6.10                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             92.5%            92.5%            98.4%                            | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         3/8 (37.5%)      3/8 (37.5%)      6/8 (75%)                        | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.107          P=0.107          P=0.006 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.022 *        P=0.022 *        P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.031 *        P=0.031 *        P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.020 *        P=0.020 *        P<0.001 **                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.100          P=0.100          P=0.003 **                       | 
|ORDER RESTRICTED   |        P=0.011 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/8 (88%)        6/7 (86%)        6/8 (75%)        5/8 (63%)        0/8 (0%)                         | 
|POLY-3 RATE (b)    |        7/7.05           6/6.05           6/6.10           5/5.15           0/0.39                           | 
|POLY-3 PERCENT (g) |        99.3%            99.2%            98.4%            97.2%            0.0%                             | 
|INT SACRIFICE 1 (c)|        7/8 (87.5%)      6/7 (85.7%)      6/8 (75%)        5/8 (62.5%)      0/8 (0%)                         | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        365 (I)          365 (I)          365 (I)          365 (I)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.738N         P=0.500N         P=0.288N         P=0.002N**                       | 
|POLY 3             |        P<0.001N**       P=0.701N         P=0.456N         P=0.237N         P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.706N         P=0.464N         P=0.247N         P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.702N         P=0.456N         P=0.235N         P<0.001N**                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.733N         P=0.500N         P=0.285N         P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         1/8 (13%)        2/8 (25%)        1/8 (13%)                        | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           1/1.34           2/2.29           1/1.34                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             74.6%            87.2%            74.6%                            | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         1/8 (12.5%)      2/8 (25%)        1/8 (12.5%)                      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.373          (e)              P=0.500          P=0.232          P=0.500                          | 
|POLY 3             |        P=0.242          (e)              P=0.173          P=0.069          P=0.173                          | 
|POLY 1.5           |        P=0.263          (e)              P=0.228          P=0.093          P=0.228                          | 
|POLY 6             |        P=0.237          (e)              P=0.159          P=0.064          P=0.159                          | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.371          (e)              P=0.500          P=0.233          P=0.500                          | 
|ORDER RESTRICTED   |        P=0.239          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         0/8 (0%)         6/8 (75%)        8/8 (100%)                       | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           0/0.39           6/6.10           8/8.00                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             98.4%            100.0%                           | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         0/8 (0%)         6/8 (75%)        8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.006 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.003 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/8 (100%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         8/8 (100%)                       | 
|POLY-3 RATE (b)    |        8/8.00           0/0.00           0/0.00           0/0.00           8/8.00                           | 
|POLY-3 PERCENT (g) |        100.0%           0.0%             0.0%             0.0%             100.0%                           | 
|INT SACRIFICE 1 (c)|        8/8 (100%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         8/8 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        365 (I)          ---              ---              ---              365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/8 (25%)                        | 
|POLY-3 RATE (b)    |        0/0.39           0/0.00           0/0.00           0/0.00           2/2.29                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             87.2%                            | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/8 (25%)                        | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.165          (e)              (e)              (e)              P=0.232                          | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.069                          | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.093                          | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.064                          | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.157          (e)              (e)              (e)              P=0.233                          | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/8 (63%)        7/7 (100%)       7/8 (88%)        8/8 (100%)       6/6 (100%)                       | 
|POLY-3 RATE (b)    |        5/5.15           7/7.00           7/7.05           8/8.00           6/6.00                           | 
|POLY-3 PERCENT (g) |        97.2%            100.0%           99.3%            100.0%           100.0%                           | 
|INT SACRIFICE 1 (c)|        5/8 (62.5%)      7/7 (100%)       7/8 (87.5%)      8/8 (100%)       6/6 (100%)                       | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        365 (I)          365 (I)          365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.177          P=0.130          P=0.288          P=0.107          P=0.159                          | 
|POLY 3             |        P=0.161          P=0.083          P=0.237          P=0.062          P=0.110                          | 
|POLY 1.5           |        P=0.160          P=0.088          P=0.247          P=0.067          P=0.117                          | 
|POLY 6             |        P=0.163          P=0.082          P=0.235          P=0.062          P=0.109                          | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.173          P=0.123          P=0.285          P=0.100          P=0.154                          | 
|ORDER RESTRICTED   |        P=0.007 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/8 (38%)        4/7 (57%)        6/8 (75%)        7/8 (88%)        7/8 (88%)                        | 
|POLY-3 RATE (b)    |        3/3.24           4/4.15           6/6.10           7/7.05           7/7.05                           | 
|POLY-3 PERCENT (g) |        92.5%            96.5%            98.4%            99.3%            99.3%                            | 
|INT SACRIFICE 1 (c)|        3/8 (37.5%)      4/7 (57.1%)      6/8 (75%)        7/8 (87.5%)      7/8 (87.5%)                      | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        365 (I)          365 (I)          365 (I)          365 (I)          365 (I)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.068          P=0.408          P=0.165          P=0.067          P=0.067                          | 
|POLY 3             |        P=0.056          P=0.313          P=0.100          P=0.024 *        P=0.024 *                        | 
|POLY 1.5           |        P=0.056          P=0.331          P=0.111          P=0.028 *        P=0.028 *                        | 
|POLY 6             |        P=0.056          P=0.308          P=0.098          P=0.023 *        P=0.023 *                        | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.065          P=0.405          P=0.157          P=0.059          P=0.059                          | 
|ORDER RESTRICTED   |        P=0.014 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/7 (0%)         2/8 (25%)        0/8 (0%)         0/8 (0%)                         | 
|POLY-3 RATE (b)    |        0/0.39           0/0.34           2/2.29           0/0.39           0/0.39                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             87.2%            0.0%             0.0%                             | 
|INT SACRIFICE 1 (c)|        0/8 (0%)         0/7 (0%)         2/8 (25%)        0/8 (0%)         0/8 (0%)                         | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              365 (I)          ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.449N         (e)              P=0.232          (e)              (e)                              | 
|POLY 3             |        P=0.217N         (e)              P=0.069          (e)              (e)                              | 
|POLY 1.5           |        P=0.253N         (e)              P=0.093          (e)              (e)                              | 
|POLY 6             |        P=0.207N         (e)              P=0.064          (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.449N         (e)              P=0.233          (e)              (e)                              | 
|ORDER RESTRICTED   |        P=0.464N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/8 (75%)        5/7 (71%)        5/8 (63%)        5/8 (63%)        0/8 (0%)                         | 
|POLY-3 RATE (b)    |        6/6.10           5/5.10           5/5.15           5/5.15           0/0.39                           | 
|POLY-3 PERCENT (g) |        98.4%            98.1%            97.2%            97.2%            0.0%                             | 
|INT SACRIFICE 1 (c)|        6/8 (75%)        5/7 (71.4%)      5/8 (62.5%)      5/8 (62.5%)      0/8 (0%)                         | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        365 (I)          365 (I)          365 (I)          365 (I)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.661N         P=0.500N         P=0.500N         P=0.006N**                       | 
|POLY 3             |        P<0.001N**       P=0.604N         P=0.439N         P=0.439N         P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.613N         P=0.450N         P=0.450N         P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.602N         P=0.437N         P=0.437N         P<0.001N**                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.662N         P=0.500N         P=0.500N         P=0.003N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
       Date:  04/27/04                           EXPERIMENT: 96022 TEST: 02                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 143 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           80 NG  /         240 NG /         800 NG /         2400 NG/                         | 
|                   |        0 UG             10 UG            30 UG            100 UG           300 UG                           | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/8 (75%)        6/7 (86%)        5/8 (63%)        5/8 (63%)        0/8 (0%)                         | 
|POLY-3 RATE (b)    |        6/6.10           6/6.05           5/5.15           5/5.15           0/0.39                           | 
|POLY-3 PERCENT (g) |        98.4%            99.2%            97.2%            97.2%            0.0%                             | 
|INT SACRIFICE 1 (c)|        6/8 (75%)        6/7 (85.7%)      5/8 (62.5%)      5/8 (62.5%)      0/8 (0%)                         | 
|TERMINAL (d)       |        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)                         | 
|FIRST INCIDENCE    |        365 (I)          365 (I)          365 (I)          365 (I)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.550          P=0.500N         P=0.500N         P=0.006N**                       | 
|POLY 3             |        P<0.001N**       P=0.504          P=0.439N         P=0.439N         P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.512          P=0.450N         P=0.450N         P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.503          P=0.437N         P=0.437N         P<0.001N**                       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.554          P=0.500N         P=0.500N         P=0.003N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).