Share This:
https://ntp.niehs.nih.gov/go/20509

TDMS Study 96022-02 Pathology Tables

NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/27/04
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 13:44:15

                                                      53 WEEK SSAC/FINAL#1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFPCBMIX

       Lock Date:  11/04/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     10/12/00 - 10/13/00

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 002    80 NG  /10 UG
                               Include 003    240 NG /30 UG
                               Include 004    800 NG /100 UG
                               Include 005    2400 NG/300 UG
                               Include 006    4000 NG/500 UG




























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/27/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 13:44:15    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/     
                                                      0 UG         10 UG        30 UG        100 UG       300 UG       500 UG       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          98           86           98           86           98           86           
                                                                                                                                    
  Scheduled Sacrifice                                 13           12           13           13           13                        
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
                                                                                                                                    
  Animals Examined Microscopically                     8            7            8            8            8                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (8)          (7)          (8)          (8)          (8)                       
      Angiectasis                                                                                          1 [2.0]                  
      Basophilic Focus                                 2            3            1            1            1                        
      Cholangiofibrosis                                                                       2 [1.5]      5 [2.4]                  
      Clear Cell Focus, Multiple                                                 1                                                  
      Eosinophilic Focus                               1                         1                                                  
      Fatty Change, Diffuse                                                                   4 [1.0]      8 [2.1]                  
      Fatty Change, Focal                              1 [1.0]                                                                      
      Hepatodiaphragmatic Nodule                                                              1                                     
      Hyperplasia, Nodular                                                                    1            8                        
      Inflammation                                     7 [1.0]      7 [1.1]      8 [1.4]      8 [1.9]      8 [1.4]                  
      Mixed Cell Focus                                 2            2            2                                                  
      Mixed Cell Focus, Multiple                       5            3            5            7                                     
      Necrosis                                         1 [1.0]      1 [1.0]      3 [1.0]      2 [1.0]      2 [1.0]                  
      Pigmentation                                                  5 [1.0]      8 [1.1]      8 [2.0]      8 [2.5]                  
      Toxic Hepatopathy                                                          2 [1.0]      8 [1.3]      8 [3.1]                  
      Bile Duct, Cyst                                                                                      1 [2.0]                  
      Bile Duct, Fibrosis                                                                                  1 [1.0]                  
      Bile Duct, Hyperplasia                                                     1 [1.0]      1 [1.0]      8 [2.1]                  
      Centrilobular, Fibrosis                                                                 5 [1.2]      8 [2.0]                  
      Hepatocyte, Hypertrophy                                       1 [1.0]      2 [1.5]      8 [1.6]      8 [3.8]                  
      Hepatocyte, Multinucleated                                                 3 [1.0]      8 [1.4]      8 [2.6]                  
      Oval Cell, Hyperplasia                                                                               8 [2.6]                  
      Portal, Fibrosis                                                                                     8 [2.0]                  
   Pancreas                                           (8)          (7)          (8)          (8)          (8)                       
      Inflammation, Chronic Active                                               1 [2.0]      2 [1.0]      1 [1.0]                  
      Acinus, Atrophy                                               1 [1.0]      1 [1.0]      1 [1.0]      1 [1.0]                  
      Acinus, Vacuolization Cytoplasmic                                                       6 [1.0]      8 [1.8]                  
   Stomach, Forestomach                               (8)                                                 (8)                       
      Edema                                                                                                1 [2.0]                  
   Stomach, Glandular                                 (8)                                                 (8)                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/27/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 13:44:15    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/     
                                                      0 UG         10 UG        30 UG        100 UG       300 UG       500 UG       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Erosion                                                                                              2 [1.5]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (8)          (7)          (8)          (8)          (8)                       
      Angiectasis                                                   2 [1.0]      3 [1.0]      4 [1.3]      1 [1.0]                  
      Atrophy                                                                                              5 [2.2]                  
      Degeneration, Cystic                                                       1 [2.0]      2 [1.5]                               
      Hyperplasia                                                                1 [2.0]      1 [2.0]      1 [2.0]                  
      Hypertrophy                                      5 [1.0]      3 [2.0]      6 [1.8]      7 [2.1]      5 [1.0]                  
      Vacuolization Cytoplasmic                        1 [1.0]      1 [1.0]      1 [1.0]      1 [1.0]                               
   Pituitary Gland                                    (8)                                                 (8)                       
      Cyst                                                                                                 1 [1.0]                  
   Thyroid Gland                                      (8)          (7)          (8)          (8)          (8)                       
      C-Cell, Hyperplasia                              1 [1.0]                                             1 [1.0]                  
      Follicular Cell, Hypertrophy                     3 [1.0]      4 [1.5]      6 [1.0]      7 [1.4]      7 [1.6]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (8)          (7)          (8)          (8)          (8)                       
      Atrophy                                          7 [3.0]      6 [2.8]      6 [3.0]      5 [3.0]                               
      Cyst                                                          1 [2.0]                                                         
   Uterus                                             (8)          (7)          (8)          (8)          (8)                       
      Inflammation, Suppurative                                                  2 [1.5]                                            
      Metaplasia, Squamous                             6 [1.8]      5 [1.6]      5 [2.0]      5 [1.8]                               
      Endometrium, Hyperplasia, Cystic                 6 [2.0]      6 [1.7]      5 [3.0]      5 [1.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (8)                                                 (8)                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 04/27/04    
Route: GAVAGE                                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     Time: 13:44:15    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       80 NG  /     240 NG /     800 NG /     2400 NG/     4000 NG/     
                                                      0 UG         10 UG        30 UG        100 UG       300 UG       500 UG       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                 1 [1.0]                                                                      
      Pigmentation                                     8 [1.5]                                             8 [1.3]                  
   Thymus                                             (8)          (7)          (8)          (8)          (6)                       
      Atrophy                                          5 [2.0]      7 [2.0]      7 [2.1]      8 [3.0]      6 [3.8]                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (8)          (2)          (1)          (1)          (8)                       
      Cyst                                             1 [3.0]                                                                      
      Hyperplasia                                      1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (8)          (7)          (8)          (8)          (8)                       
      Infiltration Cellular, Histiocyte                7 [1.1]      5 [1.2]      7 [1.0]      6 [1.3]      8 [1.4]                  
      Inflammation                                                                            1 [2.0]                               
      Pigmentation                                                                            1 [2.0]                               
      Alveolar Epithelium, Hyperplasia                                                        1 [2.0]                               
      Alveolar Epithelium, Metaplasia, Bronchiolar                               3 [1.3]      3 [2.3]      6 [1.7]                  
      Interstitium, Fibrosis                                                                  1 [3.0]                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------