TDMS Study 96022-02 Pathology Tables
NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/27/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 13:44:15 53 WEEK SSAC/FINAL#1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFPCBMIX Lock Date: 11/04/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 10/12/00 - 10/13/00 Treatment Groups: Include 001 0 NG / 0 UG Include 002 80 NG /10 UG Include 003 240 NG /30 UG Include 004 800 NG /100 UG Include 005 2400 NG/300 UG Include 006 4000 NG/500 UG a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 1 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/27/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 13:44:15 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/ 0 UG 10 UG 30 UG 100 UG 300 UG 500 UG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 98 86 98 86 98 86 Scheduled Sacrifice 13 12 13 13 13 Early Deaths Survivors Animals Examined Microscopically 8 7 8 8 8 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (8) (7) (8) (8) (8) Angiectasis 1 [2.0] Basophilic Focus 2 3 1 1 1 Cholangiofibrosis 2 [1.5] 5 [2.4] Clear Cell Focus, Multiple 1 Eosinophilic Focus 1 1 Fatty Change, Diffuse 4 [1.0] 8 [2.1] Fatty Change, Focal 1 [1.0] Hepatodiaphragmatic Nodule 1 Hyperplasia, Nodular 1 8 Inflammation 7 [1.0] 7 [1.1] 8 [1.4] 8 [1.9] 8 [1.4] Mixed Cell Focus 2 2 2 Mixed Cell Focus, Multiple 5 3 5 7 Necrosis 1 [1.0] 1 [1.0] 3 [1.0] 2 [1.0] 2 [1.0] Pigmentation 5 [1.0] 8 [1.1] 8 [2.0] 8 [2.5] Toxic Hepatopathy 2 [1.0] 8 [1.3] 8 [3.1] Bile Duct, Cyst 1 [2.0] Bile Duct, Fibrosis 1 [1.0] Bile Duct, Hyperplasia 1 [1.0] 1 [1.0] 8 [2.1] Centrilobular, Fibrosis 5 [1.2] 8 [2.0] Hepatocyte, Hypertrophy 1 [1.0] 2 [1.5] 8 [1.6] 8 [3.8] Hepatocyte, Multinucleated 3 [1.0] 8 [1.4] 8 [2.6] Oval Cell, Hyperplasia 8 [2.6] Portal, Fibrosis 8 [2.0] Pancreas (8) (7) (8) (8) (8) Inflammation, Chronic Active 1 [2.0] 2 [1.0] 1 [1.0] Acinus, Atrophy 1 [1.0] 1 [1.0] 1 [1.0] 1 [1.0] Acinus, Vacuolization Cytoplasmic 6 [1.0] 8 [1.8] Stomach, Forestomach (8) (8) Edema 1 [2.0] Stomach, Glandular (8) (8) a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 2 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/27/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 13:44:15 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/ 0 UG 10 UG 30 UG 100 UG 300 UG 500 UG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Erosion 2 [1.5] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (8) (7) (8) (8) (8) Angiectasis 2 [1.0] 3 [1.0] 4 [1.3] 1 [1.0] Atrophy 5 [2.2] Degeneration, Cystic 1 [2.0] 2 [1.5] Hyperplasia 1 [2.0] 1 [2.0] 1 [2.0] Hypertrophy 5 [1.0] 3 [2.0] 6 [1.8] 7 [2.1] 5 [1.0] Vacuolization Cytoplasmic 1 [1.0] 1 [1.0] 1 [1.0] 1 [1.0] Pituitary Gland (8) (8) Cyst 1 [1.0] Thyroid Gland (8) (7) (8) (8) (8) C-Cell, Hyperplasia 1 [1.0] 1 [1.0] Follicular Cell, Hypertrophy 3 [1.0] 4 [1.5] 6 [1.0] 7 [1.4] 7 [1.6] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (8) (7) (8) (8) (8) Atrophy 7 [3.0] 6 [2.8] 6 [3.0] 5 [3.0] Cyst 1 [2.0] Uterus (8) (7) (8) (8) (8) Inflammation, Suppurative 2 [1.5] Metaplasia, Squamous 6 [1.8] 5 [1.6] 5 [2.0] 5 [1.8] Endometrium, Hyperplasia, Cystic 6 [2.0] 6 [1.7] 5 [3.0] 5 [1.8] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (8) (8) a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 3 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/27/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 13:44:15 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG / 80 NG / 240 NG / 800 NG / 2400 NG/ 4000 NG/ 0 UG 10 UG 30 UG 100 UG 300 UG 500 UG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hematopoietic Cell Proliferation 1 [1.0] Pigmentation 8 [1.5] 8 [1.3] Thymus (8) (7) (8) (8) (6) Atrophy 5 [2.0] 7 [2.0] 7 [2.1] 8 [3.0] 6 [3.8] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (8) (2) (1) (1) (8) Cyst 1 [3.0] Hyperplasia 1 [1.0] ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (8) (7) (8) (8) (8) Infiltration Cellular, Histiocyte 7 [1.1] 5 [1.2] 7 [1.0] 6 [1.3] 8 [1.4] Inflammation 1 [2.0] Pigmentation 1 [2.0] Alveolar Epithelium, Hyperplasia 1 [2.0] Alveolar Epithelium, Metaplasia, Bronchiolar 3 [1.3] 3 [2.3] 6 [1.7] Interstitium, Fibrosis 1 [3.0] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------