https://ntp.niehs.nih.gov/go/16965

TDMS Study 05196-03 Pathology Tables

NTP Experiment-Test: 05196-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENITE                                      Date: 10/19/04
Route: DOSED WATER                                                                                                Time: 08:31:23
       Facility:  TSI Mason Research
       Chemical CAS #:  10102-18-8
       Lock Date:  02/16/93
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include 002    0       PPM
                               Include 001    0       PPM
                               Include 004    2       PPM
                               Include 003    2       PPM
                               Include 006    4       PPM
                               Include 005    4       PPM
                               Include 008    8       PPM
                               Include 007    8       PPM
                               Include 010    16      PPM
                               Include 009    16      PPM
                               Include 012    32      PPM
                               Include 011    32      PPM
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 05196-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENITE                                      Date: 10/19/04    
Route: DOSED WATER                                                                                                Time: 08:31:23    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            2            4            8            16           32              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       1           
    Moribund Sacrifice                                                                                                  1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            8           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (1)          (3)          (10)         (10)         (10)         
      Atrophy                                                                                                          10 (100%)    
      Hematopoietic Cell Proliferation, Focal          6 (60%)                   1 (33%)      3 (30%)      3 (30%)      5 (50%)     
      Hepatodiaphragmatic Nodule                       2 (20%)      1 (100%)     3 (100%)     2 (20%)                               
      Necrosis, Focal                                                                                                   1 (10%)     
      Kupffer Cell, Pigmentation, Hemosiderin                                                                           6 (60%)     
   Pancreas                                           (10)                                                (10)         (10)         
      Atrophy                                                                                                          10 (100%)    
   Salivary Glands                                    (10)                                   (10)         (10)         (10)         
      Atrophy                                                                                              1 (10%)     10 (100%)    
   Stomach, Glandular                                 (10)                                                             (10)         
      Submucosa, Edema                                                                                                  1 (10%)     
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                   2 (20%)                                                                      
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)                                                             (10)         
      Hemorrhage                                                                                                        1 (10%)     
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05196-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENITE                                      Date: 10/19/04    
Route: DOSED WATER                                                                                                Time: 08:31:23    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            2            4            8            16           32              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Clitoral Gland                                     (10)                                                (10)         (9)          
      Atrophy                                                                                                           9 (100%)    
      Inflammation, Focal, Subacute                                                                        1 (10%)                  
   Ovary                                              (9)                       (1)          (2)          (1)          (10)         
      Cyst                                             1 (11%)                   1 (100%)     2 (100%)     1 (100%)                 
   Uterus                                             (10)                      (2)          (10)         (10)         (10)         
      Endometrium, Atrophy                                                                                 2 (20%)      9 (90%)     
      Lumen, Dilatation                                1 (10%)                   2 (100%)     4 (40%)      2 (20%)                  
   Vagina                                             (10)                      (10)         (10)         (10)         (10)         
      Lumen, Concretion, Focal                                                                1 (10%)                               
      Lumen, Dilatation, Focal                                                                1 (10%)                               
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (10)                                                (10)         (10)         
      Pigmentation, Hemosiderin                                                                                         2 (20%)     
      Femoral, Depletion Cellular                                                                                      10 (100%)    
   Lymph Node, Mandibular                             (10)         (1)          (1)                       (10)         (10)         
      Depletion Lymphoid                                                                                                2 (20%)     
      Hyperplasia, Lymphoid                                                      1 (100%)                                           
   Lymph Node, Mesenteric                             (10)         (1)          (1)                       (10)         (10)         
      Congestion                                                                                                        2 (20%)     
      Depletion Lymphoid                                                                                                1 (10%)     
      Hyperplasia, Lymphoid                                         1 (100%)                                                        
      Pigmentation, Hemosiderin                       10 (100%)                                           10 (100%)    10 (100%)    
   Spleen                                             (10)                                                (10)         (10)         
      Depletion Lymphoid                                                                                                5 (50%)     
      Fibrosis, Focal                                                                                      1 (10%)                  
      Pigmentation, Hemosiderin                       10 (100%)                                           10 (100%)    10 (100%)    
   Thymus                                             (10)                                                (10)         (7)          
      Depletion Lymphoid                                                                                                6 (86%)     
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (10)                                   (8)          (10)         (9)          
      Atrophy                                                                                              4 (40%)      8 (89%)     
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05196-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENITE                                      Date: 10/19/04    
Route: DOSED WATER                                                                                                Time: 08:31:23    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            2            4            8            16           32              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (10)                                                (10)         (10)         
      Distal, Femur, Metaphysis, Atrophy                                                                               10 (100%)    
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)         (1)                                                 (10)         
      Hemorrhage, Focal                                1 (10%)                                                          1 (10%)     
      Inflammation, Focal, Subacute                    3 (30%)                                                                      
      Mineralization, Focal                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Focal, Subacute                                                                        1 (10%)                  
      Mineralization, Focal                           10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)     8 (80%)     
      Papilla, Degeneration                                         1 (10%)      3 (30%)      6 (60%)      8 (80%)      9 (90%)     
      Renal Tubule, Dilatation, Focal                                            1 (10%)      1 (10%)                   4 (40%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05196-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENITE                                      Date: 10/19/04    
Route: DOSED WATER                                                                                                Time: 08:31:23    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            2            4            8            16           32              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          20           20           20           20           20           20           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           20           20           20           20           20           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Rectum                            (10)                                                             (10)         
      Parasite Metazoan                                                                                                 1 (10%)     
   Liver                                              (10)         (3)          (3)                       (2)          (10)         
      Fatty Change                                     5 (50%)                   3 (100%)                                           
      Hematopoietic Cell Proliferation, Focal          2 (20%)                                             1 (50%)      2 (20%)     
      Hepatodiaphragmatic Nodule                       1 (10%)      3 (100%)     3 (100%)                  2 (100%)                 
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                   7 (70%)                                                          6 (60%)     
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)                                                             (10)         
      Zona Fasciculata, Vacuolization Cytoplasmic     10 (100%)                                                         4 (40%)     
   Pituitary Gland                                    (10)                                                             (10)         
      Cyst                                                                                                              1 (10%)     
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05196-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENITE                                      Date: 10/19/04    
Route: DOSED WATER                                                                                                Time: 08:31:23    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            2            4            8            16           32              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Lymph Node, Mandibular                             (10)                      (10)         (10)         (8)          (10)         
      Congestion                                       2 (20%)                                                          2 (20%)     
      Depletion Lymphoid                                                                                                1 (10%)     
   Lymph Node, Mesenteric                             (10)                      (10)         (10)         (10)         (10)         
      Congestion                                                                                                        5 (50%)     
      Pigmentation, Hemosiderin                       10 (100%)                                           10 (100%)    10 (100%)    
   Spleen                                             (10)                      (10)         (10)         (10)         (10)         
      Pigmentation, Hemosiderin                       10 (100%)                                           10 (100%)    10 (100%)    
   Thymus                                             (10)                      (10)         (10)         (10)         (10)         
      Congestion                                                                                           1 (10%)                  
      Depletion Lymphoid                                                                                                4 (40%)     
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (10)         (1)                                                 (10)         
      Pinna, Hyperplasia, Focal                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)                                                             (10)         
      Hemorrhage, Focal                                2 (20%)                                                          1 (10%)     
      Inflammation, Focal, Subacute                                                                                     1 (10%)     
      Interstitium, Inflammation, Chronic, Focal       1 (10%)                                                                      
      Pleura, Fibrosis, Focal                          1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05196-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENITE                                      Date: 10/19/04    
Route: DOSED WATER                                                                                                Time: 08:31:23    
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            2            4            8            16           32              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hemorrhage, Focal                                                                                                 1 (10%)     
      Inflammation, Focal, Subacute                                                                                     1 (10%)     
      Papilla, Degeneration                            1 (10%)                   1 (10%)      2 (20%)      5 (50%)      7 (70%)     
      Renal Tubule, Dilatation                                                                                          3 (30%)     
      Renal Tubule, Dilatation, Focal                  3 (30%)      3 (30%)      3 (30%)      6 (60%)      2 (20%)      2 (20%)     
      Renal Tubule, Regeneration                      10 (100%)     9 (90%)      9 (90%)      9 (90%)     10 (100%)     8 (80%)     
   Urinary Bladder                                    (10)         (1)                                                 (10)         
      Calculus Micro Observation Only                               1 (100%)                                                        
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
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