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TDMS Study 96018-04 Pathology Tables

NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03
Route: DOSED WATER                                                                                                Time: 10:55:48

                                                         FINAL #1/MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  75-27-4

       Lock Date:  02/18/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03    
Route: DOSED WATER                                                                                                Time: 10:55:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            7           12            7                                     
    Moribund Sacrifice                                 7            6            5            4                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           36           33           39                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (48)         (48)         (49)                                   
      Edema                                           10 (20%)      8 (17%)      8 (17%)      4 (8%)                                
      Hemorrhage                                       1 (2%)                                                                       
   Intestine Small, Duodenum                          (48)         (48)         (46)         (46)                                   
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Epithelium, Hyperplasia                          1 (2%)       1 (2%)       2 (4%)                                             
   Intestine Small, Jejunum                           (46)         (49)         (48)         (48)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Intestine Small, Ileum                             (45)         (46)         (49)         (49)                                   
      Diverticulum                                                               1 (2%)                                             
      Epithelium, Hyperplasia                                       1 (2%)       2 (4%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                 3 (6%)                    5 (10%)      2 (4%)                                
      Clear Cell Focus                                 2 (4%)       1 (2%)       2 (4%)       3 (6%)                                
      Cyst                                             2 (4%)                                                                       
      Eosinophilic Focus                               7 (14%)      4 (8%)       8 (16%)      4 (8%)                                
      Hematopoietic Cell Proliferation                 4 (8%)       2 (4%)       1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            2 (4%)       5 (10%)      6 (12%)      1 (2%)                                
      Infarct                                                                                 2 (4%)                                
      Infiltration Cellular, Mixed Cell                6 (12%)      6 (12%)      7 (14%)      5 (10%)                               
      Mixed Cell Focus                                 3 (6%)       3 (6%)       3 (6%)       2 (4%)                                
      Necrosis, Focal                                  3 (6%)       5 (10%)      2 (4%)       4 (8%)                                
      Tension Lipidosis                                2 (4%)                                 2 (4%)                                
      Centrilobular, Necrosis                          6 (12%)      1 (2%)       2 (4%)       3 (6%)                                
      Hepatocyte, Depletion Glycogen                   3 (6%)       2 (4%)       1 (2%)                                             
      Hepatocyte, Karyomegaly                          2 (4%)       4 (8%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic            6 (12%)      3 (6%)       6 (12%)      3 (6%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03    
Route: DOSED WATER                                                                                                Time: 10:55:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Kupffer Cell, Hyperplasia                        2 (4%)       1 (2%)                                                          
      Kupffer Cell, Pigmentation                       7 (14%)                   2 (4%)       1 (2%)                                
   Mesentery                                          (21)         (17)         (16)         (17)                                   
      Angiectasis                                      1 (5%)                                                                       
      Hemorrhage                                                    2 (12%)                                                         
      Necrosis                                         1 (5%)                                                                       
      Fat, Necrosis                                   12 (57%)      8 (47%)     11 (69%)     13 (76%)                               
   Pancreas                                           (50)         (48)         (49)         (49)                                   
      Atrophy                                          1 (2%)       2 (4%)       2 (4%)                                             
      Cyst                                                          1 (2%)       1 (2%)                                             
      Acinus, Cytoplasmic Alteration                                3 (6%)       2 (4%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia, Lymphoid                           25 (50%)     22 (44%)     26 (52%)     20 (40%)                               
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Edema                                            2 (4%)       1 (2%)       2 (4%)                                             
      Erosion                                          1 (2%)                                 1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                                  4 (8%)                    1 (2%)                                
      Ulcer                                                                      2 (4%)                                             
      Epithelium, Hyperplasia                          2 (4%)       3 (6%)       4 (8%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (49)         (49)         (50)                                   
      Cyst                                             2 (4%)                    2 (4%)                                             
      Edema                                            2 (4%)                    1 (2%)       1 (2%)                                
      Erosion                                          1 (2%)       1 (2%)       1 (2%)                                             
   Tooth                                                                        (1)                                                 
      Malformation                                                               1 (100%)                                           
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 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 (2%)       1 (2%)                    1 (2%)                                
      Mineralization                                   3 (6%)                                                                       
      Thrombosis                                                    1 (2%)                    1 (2%)                                
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (49)                                   
      Accessory Adrenal Cortical Nodule                8 (16%)      5 (10%)      5 (10%)     10 (20%)                               
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03    
Route: DOSED WATER                                                                                                Time: 10:55:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hypertrophy, Focal                               1 (2%)       1 (2%)       2 (4%)                                             
      Zona Reticularis, Vacuolization Cytoplasmic                   2 (4%)       1 (2%)                                             
   Adrenal Medulla                                    (50)         (48)         (49)         (49)                                   
      Hyperplasia                                      2 (4%)                                 2 (4%)                                
   Islets, Pancreatic                                 (49)         (48)         (48)         (49)                                   
      Hyperplasia                                      1 (2%)       4 (8%)       3 (6%)       1 (2%)                                
   Parathyroid Gland                                  (47)         (48)         (46)         (47)                                   
      Cyst                                             2 (4%)                                 1 (2%)                                
   Pituitary Gland                                    (49)         (50)         (49)         (49)                                   
      Pars Distalis, Angiectasis                       1 (2%)                    1 (2%)       1 (2%)                                
      Pars Distalis, Cyst                              1 (2%)       4 (8%)                    3 (6%)                                
      Pars Distalis, Hyperplasia, Focal                6 (12%)      6 (12%)      1 (2%)       4 (8%)                                
   Thyroid Gland                                      (50)         (49)         (49)         (50)                                   
      Degeneration, Cystic                            26 (52%)     17 (35%)     12 (24%)     11 (22%)                               
      Follicular Cell, Hyperplasia                     6 (12%)      1 (2%)       5 (10%)      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (49)         (48)         (49)                                   
      Inflammation, Chronic                            1 (2%)       1 (2%)       4 (8%)       1 (2%)                                
   Ovary                                              (50)         (49)         (50)         (49)                                   
      Angiectasis                                      5 (10%)      6 (12%)      5 (10%)      9 (18%)                               
      Cyst                                             8 (16%)     13 (27%)     11 (22%)     14 (29%)                               
      Thrombosis                                       1 (2%)                                 1 (2%)                                
      Corpus Luteum, Hyperplasia                       3 (6%)       1 (2%)       3 (6%)                                             
      Granulosa Cell, Hyperplasia                                                             2 (4%)                                
      Interstitial Cell, Hyperplasia                   1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   3 (6%)       1 (2%)                                             
      Hyperplasia, Cystic                             45 (90%)     45 (90%)     43 (86%)     46 (92%)                               
      Inflammation, Chronic                            2 (4%)       2 (4%)                    1 (2%)                                
      Metaplasia, Squamous                                          1 (2%)       2 (4%)       2 (4%)                                
      Endometrium, Hyperplasia, Atypical                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03    
Route: DOSED WATER                                                                                                Time: 10:55:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     22 (44%)     24 (48%)     18 (36%)     11 (22%)                               
      Myelofibrosis                                    3 (6%)       1 (2%)       1 (2%)                                             
   Lymph Node                                         (16)         (9)          (7)          (4)                                    
      Iliac, Hemorrhage                                1 (6%)                    1 (14%)                                            
      Iliac, Hyperplasia, Lymphoid                     3 (19%)                                                                      
      Mediastinal, Hemorrhage                          1 (6%)       1 (11%)                                                         
      Renal, Hyperplasia, Lymphoid                                                            1 (25%)                               
   Lymph Node, Mandibular                             (50)         (50)         (50)         (47)                                   
      Atrophy                                          2 (4%)                    1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)                    1 (2%)                                
      Hemorrhage                                                    3 (6%)       2 (4%)       3 (6%)                                
      Hyperplasia, Lymphoid                            8 (16%)      9 (18%)      6 (12%)      9 (19%)                               
      Pigmentation                                    22 (44%)     27 (54%)     25 (50%)     20 (43%)                               
   Lymph Node, Mesenteric                             (49)         (48)         (46)         (50)                                   
      Atrophy                                          1 (2%)                                 2 (4%)                                
      Hematopoietic Cell Proliferation                                           2 (4%)       2 (4%)                                
      Hemorrhage                                       3 (6%)       2 (4%)       3 (7%)                                             
      Hyperplasia, Lymphoid                            6 (12%)      9 (19%)      4 (9%)       7 (14%)                               
      Pigmentation                                     1 (2%)                    1 (2%)                                             
   Spleen                                             (50)         (49)         (48)         (50)                                   
      Hematopoietic Cell Proliferation                42 (84%)     30 (61%)     32 (67%)     29 (58%)                               
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Hyperplasia, Lymphoid                            3 (6%)       1 (2%)       2 (4%)       3 (6%)                                
      Metaplasia, Osseous                                                                     1 (2%)                                
      Pigmentation                                    29 (58%)     22 (45%)     30 (63%)     27 (54%)                               
      Lymphoid Follicle, Atrophy                                                 1 (2%)       1 (2%)                                
      Lymphoid Follicle, Hyperplasia                   5 (10%)      8 (16%)     13 (27%)     14 (28%)                               
   Thymus                                             (49)         (49)         (50)         (47)                                   
      Atrophy                                          9 (18%)      3 (6%)       6 (12%)      4 (9%)                                
      Hyperplasia, Lymphoid                            1 (2%)       3 (6%)       4 (8%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      9 (18%)      4 (8%)       4 (8%)       2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Edema                                            2 (4%)                                 1 (2%)                                
      Ulcer                                            1 (2%)       1 (2%)       1 (2%)                                             
      Epidermis, Hyperplasia                           1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03    
Route: DOSED WATER                                                                                                Time: 10:55:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                                  3 (6%)       1 (2%)       1 (2%)                                
   Skeletal Muscle                                    (5)          (2)          (4)          (1)                                    
      Atrophy                                          1 (20%)      1 (50%)                                                         
      Inflammation, Chronic                            1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                      2 (4%)                                                                       
      Cyst Epithelial Inclusion                        1 (2%)                    1 (2%)                                             
      Hemorrhage                                                    2 (4%)       1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Peripheral Nerve                                   (5)          (4)          (1)          (1)                                    
      Atrophy                                          3 (60%)      2 (50%)                                                         
      Inflammation, Chronic                                         1 (25%)                                                         
   Spinal Cord                                        (4)          (4)          (2)          (1)                                    
      Atrophy                                                                    1 (50%)                                            
      Hemorrhage                                                    1 (25%)      1 (50%)                                            
      Necrosis                                                      1 (25%)      1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Edema                                            1 (2%)       1 (2%)       1 (2%)                                             
      Emphysema                                                                  1 (2%)                                             
      Foreign Body                                     1 (2%)                                 2 (4%)                                
      Hemorrhage                                       6 (12%)      7 (14%)      6 (12%)      7 (14%)                               
      Hyperplasia, Lymphoid                            1 (2%)                    4 (8%)       1 (2%)                                
      Infiltration Cellular, Polymorphonuclear                      1 (2%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                2 (4%)       1 (2%)       5 (10%)                                            
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Thrombosis                                       1 (2%)       2 (4%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              2 (4%)       1 (2%)       2 (4%)                                
      Alveolar Epithelium, Metaplasia, Bronchiolar                  2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03    
Route: DOSED WATER                                                                                                Time: 10:55:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
   Eye                                                (48)         (50)         (50)         (50)                                   
      Developmental Malformation                       1 (2%)                                 4 (8%)                                
      Hemorrhage                                                    2 (4%)                                                          
      Inflammation, Chronic                                                                   2 (4%)                                
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                               1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Hyperplasia, Lymphoid                            8 (16%)      5 (10%)      5 (10%)      3 (6%)                                
      Infarct                                          2 (4%)       2 (4%)       3 (6%)       5 (10%)                               
      Inflammation, Focal, Mixed Cell                                            1 (2%)                                             
      Metaplasia, Osseous                              2 (4%)                                 1 (2%)                                
      Nephropathy                                     16 (32%)     14 (29%)      7 (14%)      8 (16%)                               
      Renal Tubule, Accumulation, Hyaline Droplet      2 (4%)       6 (12%)      4 (8%)       1 (2%)                                
      Renal Tubule, Necrosis                           2 (4%)                    2 (4%)       1 (2%)                                
      Renal Tubule, Pigmentation                       2 (4%)                                 1 (2%)                                
      Renal Tubule, Regeneration                                                 1 (2%)                                             
      Renal Tubule, Vacuolization Cytoplasmic                       1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (50)         (49)         (48)         (50)                                   
      Edema                                                         2 (4%)                    1 (2%)                                
      Hyperplasia, Lymphoid                           11 (22%)      7 (14%)      4 (8%)      10 (20%)                               
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Transitional Epithelium, Hyperplasia                          1 (2%)       1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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