Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/16485

TDMS Study 96018-04 Pathology Tables

NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03
Route: DOSED WATER                                                                                                Time: 10:55:48

                                                         FINAL #1/MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  75-27-4

       Lock Date:  02/18/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03    
Route: DOSED WATER                                                                                                Time: 10:55:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            7           12            7                                     
    Moribund Sacrifice                                 7            6            5            4                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           36           33           39                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (48)         (48)         (49)                                   
      Edema                                           10 (20%)      8 (17%)      8 (17%)      4 (8%)                                
      Hemorrhage                                       1 (2%)                                                                       
   Intestine Small, Duodenum                          (48)         (48)         (46)         (46)                                   
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Epithelium, Hyperplasia                          1 (2%)       1 (2%)       2 (4%)                                             
   Intestine Small, Jejunum                           (46)         (49)         (48)         (48)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Intestine Small, Ileum                             (45)         (46)         (49)         (49)                                   
      Diverticulum                                                               1 (2%)                                             
      Epithelium, Hyperplasia                                       1 (2%)       2 (4%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                 3 (6%)                    5 (10%)      2 (4%)                                
      Clear Cell Focus                                 2 (4%)       1 (2%)       2 (4%)       3 (6%)                                
      Cyst                                             2 (4%)                                                                       
      Eosinophilic Focus                               7 (14%)      4 (8%)       8 (16%)      4 (8%)                                
      Hematopoietic Cell Proliferation                 4 (8%)       2 (4%)       1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            2 (4%)       5 (10%)      6 (12%)      1 (2%)                                
      Infarct                                                                                 2 (4%)                                
      Infiltration Cellular, Mixed Cell                6 (12%)      6 (12%)      7 (14%)      5 (10%)                               
      Mixed Cell Focus                                 3 (6%)       3 (6%)       3 (6%)       2 (4%)                                
      Necrosis, Focal                                  3 (6%)       5 (10%)      2 (4%)       4 (8%)                                
      Tension Lipidosis                                2 (4%)                                 2 (4%)                                
      Centrilobular, Necrosis                          6 (12%)      1 (2%)       2 (4%)       3 (6%)                                
      Hepatocyte, Depletion Glycogen                   3 (6%)       2 (4%)       1 (2%)                                             
      Hepatocyte, Karyomegaly                          2 (4%)       4 (8%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic            6 (12%)      3 (6%)       6 (12%)      3 (6%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03    
Route: DOSED WATER                                                                                                Time: 10:55:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Kupffer Cell, Hyperplasia                        2 (4%)       1 (2%)                                                          
      Kupffer Cell, Pigmentation                       7 (14%)                   2 (4%)       1 (2%)                                
   Mesentery                                          (21)         (17)         (16)         (17)                                   
      Angiectasis                                      1 (5%)                                                                       
      Hemorrhage                                                    2 (12%)                                                         
      Necrosis                                         1 (5%)                                                                       
      Fat, Necrosis                                   12 (57%)      8 (47%)     11 (69%)     13 (76%)                               
   Pancreas                                           (50)         (48)         (49)         (49)                                   
      Atrophy                                          1 (2%)       2 (4%)       2 (4%)                                             
      Cyst                                                          1 (2%)       1 (2%)                                             
      Acinus, Cytoplasmic Alteration                                3 (6%)       2 (4%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia, Lymphoid                           25 (50%)     22 (44%)     26 (52%)     20 (40%)                               
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Edema                                            2 (4%)       1 (2%)       2 (4%)                                             
      Erosion                                          1 (2%)                                 1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic Active                                  4 (8%)                    1 (2%)                                
      Ulcer                                                                      2 (4%)                                             
      Epithelium, Hyperplasia                          2 (4%)       3 (6%)       4 (8%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (49)         (49)         (50)                                   
      Cyst                                             2 (4%)                    2 (4%)                                             
      Edema                                            2 (4%)                    1 (2%)       1 (2%)                                
      Erosion                                          1 (2%)       1 (2%)       1 (2%)                                             
   Tooth                                                                        (1)                                                 
      Malformation                                                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 (2%)       1 (2%)                    1 (2%)                                
      Mineralization                                   3 (6%)                                                                       
      Thrombosis                                                    1 (2%)                    1 (2%)                                
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (49)                                   
      Accessory Adrenal Cortical Nodule                8 (16%)      5 (10%)      5 (10%)     10 (20%)                               
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03    
Route: DOSED WATER                                                                                                Time: 10:55:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hypertrophy, Focal                               1 (2%)       1 (2%)       2 (4%)                                             
      Zona Reticularis, Vacuolization Cytoplasmic                   2 (4%)       1 (2%)                                             
   Adrenal Medulla                                    (50)         (48)         (49)         (49)                                   
      Hyperplasia                                      2 (4%)                                 2 (4%)                                
   Islets, Pancreatic                                 (49)         (48)         (48)         (49)                                   
      Hyperplasia                                      1 (2%)       4 (8%)       3 (6%)       1 (2%)                                
   Parathyroid Gland                                  (47)         (48)         (46)         (47)                                   
      Cyst                                             2 (4%)                                 1 (2%)                                
   Pituitary Gland                                    (49)         (50)         (49)         (49)                                   
      Pars Distalis, Angiectasis                       1 (2%)                    1 (2%)       1 (2%)                                
      Pars Distalis, Cyst                              1 (2%)       4 (8%)                    3 (6%)                                
      Pars Distalis, Hyperplasia, Focal                6 (12%)      6 (12%)      1 (2%)       4 (8%)                                
   Thyroid Gland                                      (50)         (49)         (49)         (50)                                   
      Degeneration, Cystic                            26 (52%)     17 (35%)     12 (24%)     11 (22%)                               
      Follicular Cell, Hyperplasia                     6 (12%)      1 (2%)       5 (10%)      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (49)         (48)         (49)                                   
      Inflammation, Chronic                            1 (2%)       1 (2%)       4 (8%)       1 (2%)                                
   Ovary                                              (50)         (49)         (50)         (49)                                   
      Angiectasis                                      5 (10%)      6 (12%)      5 (10%)      9 (18%)                               
      Cyst                                             8 (16%)     13 (27%)     11 (22%)     14 (29%)                               
      Thrombosis                                       1 (2%)                                 1 (2%)                                
      Corpus Luteum, Hyperplasia                       3 (6%)       1 (2%)       3 (6%)                                             
      Granulosa Cell, Hyperplasia                                                             2 (4%)                                
      Interstitial Cell, Hyperplasia                   1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   3 (6%)       1 (2%)                                             
      Hyperplasia, Cystic                             45 (90%)     45 (90%)     43 (86%)     46 (92%)                               
      Inflammation, Chronic                            2 (4%)       2 (4%)                    1 (2%)                                
      Metaplasia, Squamous                                          1 (2%)       2 (4%)       2 (4%)                                
      Endometrium, Hyperplasia, Atypical                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03    
Route: DOSED WATER                                                                                                Time: 10:55:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     22 (44%)     24 (48%)     18 (36%)     11 (22%)                               
      Myelofibrosis                                    3 (6%)       1 (2%)       1 (2%)                                             
   Lymph Node                                         (16)         (9)          (7)          (4)                                    
      Iliac, Hemorrhage                                1 (6%)                    1 (14%)                                            
      Iliac, Hyperplasia, Lymphoid                     3 (19%)                                                                      
      Mediastinal, Hemorrhage                          1 (6%)       1 (11%)                                                         
      Renal, Hyperplasia, Lymphoid                                                            1 (25%)                               
   Lymph Node, Mandibular                             (50)         (50)         (50)         (47)                                   
      Atrophy                                          2 (4%)                    1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)                    1 (2%)                                
      Hemorrhage                                                    3 (6%)       2 (4%)       3 (6%)                                
      Hyperplasia, Lymphoid                            8 (16%)      9 (18%)      6 (12%)      9 (19%)                               
      Pigmentation                                    22 (44%)     27 (54%)     25 (50%)     20 (43%)                               
   Lymph Node, Mesenteric                             (49)         (48)         (46)         (50)                                   
      Atrophy                                          1 (2%)                                 2 (4%)                                
      Hematopoietic Cell Proliferation                                           2 (4%)       2 (4%)                                
      Hemorrhage                                       3 (6%)       2 (4%)       3 (7%)                                             
      Hyperplasia, Lymphoid                            6 (12%)      9 (19%)      4 (9%)       7 (14%)                               
      Pigmentation                                     1 (2%)                    1 (2%)                                             
   Spleen                                             (50)         (49)         (48)         (50)                                   
      Hematopoietic Cell Proliferation                42 (84%)     30 (61%)     32 (67%)     29 (58%)                               
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Hyperplasia, Lymphoid                            3 (6%)       1 (2%)       2 (4%)       3 (6%)                                
      Metaplasia, Osseous                                                                     1 (2%)                                
      Pigmentation                                    29 (58%)     22 (45%)     30 (63%)     27 (54%)                               
      Lymphoid Follicle, Atrophy                                                 1 (2%)       1 (2%)                                
      Lymphoid Follicle, Hyperplasia                   5 (10%)      8 (16%)     13 (27%)     14 (28%)                               
   Thymus                                             (49)         (49)         (50)         (47)                                   
      Atrophy                                          9 (18%)      3 (6%)       6 (12%)      4 (9%)                                
      Hyperplasia, Lymphoid                            1 (2%)       3 (6%)       4 (8%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      9 (18%)      4 (8%)       4 (8%)       2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Edema                                            2 (4%)                                 1 (2%)                                
      Ulcer                                            1 (2%)       1 (2%)       1 (2%)                                             
      Epidermis, Hyperplasia                           1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03    
Route: DOSED WATER                                                                                                Time: 10:55:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                                  3 (6%)       1 (2%)       1 (2%)                                
   Skeletal Muscle                                    (5)          (2)          (4)          (1)                                    
      Atrophy                                          1 (20%)      1 (50%)                                                         
      Inflammation, Chronic                            1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                      2 (4%)                                                                       
      Cyst Epithelial Inclusion                        1 (2%)                    1 (2%)                                             
      Hemorrhage                                                    2 (4%)       1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Peripheral Nerve                                   (5)          (4)          (1)          (1)                                    
      Atrophy                                          3 (60%)      2 (50%)                                                         
      Inflammation, Chronic                                         1 (25%)                                                         
   Spinal Cord                                        (4)          (4)          (2)          (1)                                    
      Atrophy                                                                    1 (50%)                                            
      Hemorrhage                                                    1 (25%)      1 (50%)                                            
      Necrosis                                                      1 (25%)      1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Edema                                            1 (2%)       1 (2%)       1 (2%)                                             
      Emphysema                                                                  1 (2%)                                             
      Foreign Body                                     1 (2%)                                 2 (4%)                                
      Hemorrhage                                       6 (12%)      7 (14%)      6 (12%)      7 (14%)                               
      Hyperplasia, Lymphoid                            1 (2%)                    4 (8%)       1 (2%)                                
      Infiltration Cellular, Polymorphonuclear                      1 (2%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                2 (4%)       1 (2%)       5 (10%)                                            
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Thrombosis                                       1 (2%)       2 (4%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              2 (4%)       1 (2%)       2 (4%)                                
      Alveolar Epithelium, Metaplasia, Bronchiolar                  2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/25/03    
Route: DOSED WATER                                                                                                Time: 10:55:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
   Eye                                                (48)         (50)         (50)         (50)                                   
      Developmental Malformation                       1 (2%)                                 4 (8%)                                
      Hemorrhage                                                    2 (4%)                                                          
      Inflammation, Chronic                                                                   2 (4%)                                
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                               1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Hyperplasia, Lymphoid                            8 (16%)      5 (10%)      5 (10%)      3 (6%)                                
      Infarct                                          2 (4%)       2 (4%)       3 (6%)       5 (10%)                               
      Inflammation, Focal, Mixed Cell                                            1 (2%)                                             
      Metaplasia, Osseous                              2 (4%)                                 1 (2%)                                
      Nephropathy                                     16 (32%)     14 (29%)      7 (14%)      8 (16%)                               
      Renal Tubule, Accumulation, Hyaline Droplet      2 (4%)       6 (12%)      4 (8%)       1 (2%)                                
      Renal Tubule, Necrosis                           2 (4%)                    2 (4%)       1 (2%)                                
      Renal Tubule, Pigmentation                       2 (4%)                                 1 (2%)                                
      Renal Tubule, Regeneration                                                 1 (2%)                                             
      Renal Tubule, Vacuolization Cytoplasmic                       1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (50)         (49)         (48)         (50)                                   
      Edema                                                         2 (4%)                    1 (2%)                                
      Hyperplasia, Lymphoid                           11 (22%)      7 (14%)      4 (8%)      10 (20%)                               
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Transitional Epithelium, Hyperplasia                          1 (2%)       1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------