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TDMS Study 05195-04 Pathology Tables

NTP Experiment-Test: 05195-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENATE                                      Date: 10/18/04
Route: DOSED WATER                                                                                                Time: 14:24:19




       Facility:  TSI Mason Research

       Chemical CAS #:  13410-01-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 002    0       PPM
                               Include 001    0       PPM
                               Include 004    3.75    PPM
                               Include 003    3.75    PPM
                               Include 006    7.5     PPM
                               Include 005    7.5     PPM
                               Include 008    15      PPM
                               Include 007    15      PPM
                               Include 010    30      PPM
                               Include 009    30      PPM
                               Include 012    60      PPM
                               Include 011    60      PPM

























a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 05195-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENATE                                      Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 14:24:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            3.75         7.5          15           30           60              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
                                                                                                                                    
  Animals Examined Microscopically                    10            8            7            3           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                      (1)                       (10)         (10)         
      Developmental Malformation                       1 (10%)                   1 (100%)                                           
      Hematopoietic Cell Proliferation, Focal          5 (50%)                                             3 (30%)      4 (40%)     
   Salivary Glands                                    (10)                                                (10)         (10)         
      Inflammation, Focal, Subacute                    2 (20%)                                                          3 (30%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (9)          (1)                                                 (10)         
      Pigmentation, Melanin                                         1 (100%)                                                        
   Uterus                                             (10)                                   (1)          (10)         (10)         
      Endometrium, Edema                               1 (10%)                                             1 (10%)      3 (30%)     
      Lumen, Dilatation                                1 (10%)                                             1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 05195-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENATE                                      Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 14:24:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0            3.75         7.5          15           30           60              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)                                                             (10)         
      Hyperplasia, Lymphoid                                                                                             1 (10%)     
   Lymph Node, Mesenteric                             (10)                                                             (10)         
      Lymphocyte, Depletion Cellular                                                                                    1 (10%)     
   Spleen                                             (10)                                                             (10)         
      Pigmentation, Hemosiderin                        1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (1)                                                 (10)         
      Congestion                                                    1 (100%)                                                        
      Hemorrhage, Focal                                1 (10%)                                                          2 (20%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                (10)         (10)         
      Inflammation, Focal, Subacute                                                                                     3 (30%)     
      Inflammation, Subacute                           3 (30%)                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 05195-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENATE                                      Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 14:24:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            3.75         7.5          15           30           60              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
                                                                                                                                    
  Animals Examined Microscopically                    10            7            8            7            7           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                                                             (10)         
      Hematopoietic Cell Proliferation, Focal          2 (20%)                                                          3 (30%)     
   Mesentery                                                       (1)                                                              
      Necrosis                                                      1 (100%)                                                        
      Fat, Developmental Malformation                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (10)                                                             (10)         
      Lymphocyte, Depletion Cellular                                                                                    1 (10%)     
   Spleen                                             (10)         (1)                                                 (10)         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 05195-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  SODIUM SELENATE                                      Date: 10/18/04    
Route: DOSED WATER                                                                                                Time: 14:24:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0            3.75         7.5          15           30           60              
                                                   PPM          PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pigmentation, Hemosiderin                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                                           (1)                                    
      Hyperplasia                                                                             1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Urinary Bladder                                    (10)         (2)          (1)          (2)                       (10)         
      Calculus Gross Observation                                    2 (100%)     1 (100%)     1 (50%)                   2 (20%)     
      Calculus Micro Observation Only                  2 (20%)      2 (100%)     1 (100%)     1 (50%)                   4 (40%)     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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