National Toxicology Program

National Toxicology Program
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TDMS Study 96018-04 Pathology Tables

NTP Experiment-Test: 96018-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/31/03
Route: DOSED WATER                                                                                                Time: 10:54:02

                                                          FINAL#1 MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  75-27-4

       Lock Date:  02/18/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96018-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/31/03  
Route: DOSED WATER                                                                                                Time: 10:54:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            7           12            7                                     
    Moribund Sacrifice                                 7            6            5            4                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           36           33           39                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (46)         (45)         (48)         (45)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Intestine Large, Colon                             (50)         (49)         (49)         (49)                                   
   Intestine Large, Cecum                             (49)         (48)         (48)         (49)                                   
   Intestine Small, Duodenum                          (48)         (48)         (46)         (46)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (49)         (48)         (48)                                   
      Carcinoma                                                     1 (2%)                                                          
      Leiomyosarcoma                                                             1 (2%)                                             
   Intestine Small, Ileum                             (45)         (46)         (49)         (49)                                   
      Carcinoma                                        1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  2 (4%)       1 (2%)                                                          
      Hepatoblastoma                                   1 (2%)                                 1 (2%)                                
      Hepatocellular Carcinoma                         9 (18%)      3 (6%)      10 (20%)      6 (12%)                               
      Hepatocellular Carcinoma, Multiple               4 (8%)       3 (6%)       2 (4%)       1 (2%)                                
      Hepatocellular Adenoma                          10 (20%)     12 (24%)     11 (22%)      9 (18%)                               
      Hepatocellular Adenoma, Multiple                14 (28%)      6 (12%)      8 (16%)      7 (14%)                               
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       1 (2%)                                
   Mesentery                                          (21)         (17)         (16)         (17)                                   
      Hemangioma                                                    1 (6%)                                                          
      Hemangiosarcoma                                  1 (5%)                                                                       
      Hepatoblastoma, Metastatic, Liver                1 (5%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (6%)                                             
      Histiocytic Sarcoma                                                                     1 (6%)                                
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Glandular                                                              1 (6%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/31/03  
Route: DOSED WATER                                                                                                Time: 10:54:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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ALIMENTARY SYSTEM - cont                                                                                                            
      Rhabdomyosarcoma, Metastatic, Skeletal Muscle                              1 (6%)                                             
      Sarcoma, Metastatic, Skin                                     1 (6%)                                                          
      Sarcoma, Metastatic, Skeletal Muscle             1 (5%)                                                                       
   Pancreas                                           (50)         (48)         (49)         (49)                                   
      Sarcoma, Metastatic, Skeletal Muscle             2 (4%)                                                                       
      Acinus, Rhabdomyosarcoma, Metastatic,                                                                                         
          Skeletal Muscle                                                        1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma                                                       1 (2%)                                                          
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)                    2 (4%)                                
   Stomach, Glandular                                 (50)         (49)         (49)         (50)                                   
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Leiomyosarcoma                                                             1 (2%)                                             
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 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
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 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Capsule, Adenoma                                              1 (2%)                                                          
   Adrenal Medulla                                    (50)         (48)         (49)         (49)                                   
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (48)         (48)         (49)                                   
      Adenoma                                          3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Carcinoma                                                                               1 (2%)                                
   Pituitary Gland                                    (49)         (50)         (49)         (49)                                   
      Schwannoma Malignant, Metastatic, Brain                                                 1 (2%)                                
      Pars Distalis, Adenoma                           3 (6%)       3 (6%)       1 (2%)       3 (6%)                                
      Pars Intermedia, Adenoma                         2 (4%)                                                                       
   Thyroid Gland                                      (50)         (49)         (49)         (50)                                   
      Follicular Cell, Adenoma                         2 (4%)                    1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                                    1 (2%)       1 (2%)                                             
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                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/31/03  
Route: DOSED WATER                                                                                                Time: 10:54:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (49)         (48)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Ovary                                              (50)         (49)         (50)         (49)                                   
      Cystadenoma                                      4 (8%)       1 (2%)       1 (2%)       1 (2%)                                
      Granulosa Cell Tumor Benign                      1 (2%)                    1 (2%)                                             
      Hemangiosarcoma                                  2 (4%)       1 (2%)                    4 (8%)                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       1 (2%)                                
      Tubulostromal Adenoma                                                      1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Deciduoma Benign                                 1 (2%)       1 (2%)                                                          
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  2 (4%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       1 (2%)                                
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                                 1 (2%)                                                          
      Sarcoma Stromal                                  2 (4%)                                                                       
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 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  2 (4%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       1 (2%)                                
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Lymph Node                                         (16)         (9)          (7)          (4)                                    
      Sarcoma                                          1 (6%)                                                                       
      Bronchial, Hepatoblastoma, Metastatic, Liver     1 (6%)                                                                       
      Iliac, Rhabdomyosarcoma, Metastatic,                                                                                          
          Skeletal Muscle                                                        1 (14%)                                            
      Inguinal, Histiocytic Sarcoma                                              1 (14%)                                            
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                      1 (14%)                                            
      Mediastinal, Rhabdomyosarcoma, Metastatic,                                                                                    
           Skeletal Muscle                                                       1 (14%)                                            
      Mediastinal, Sarcoma, Metastatic, Skeletal                                                                                    
          Muscle                                       2 (13%)                                                                      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/31/03  
Route: DOSED WATER                                                                                                Time: 10:54:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Pancreatic, Hemangiosarcoma                      1 (6%)                                                                       
   Lymph Node, Mandibular                             (50)         (50)         (50)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Lymph Node, Mesenteric                             (49)         (48)         (46)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                                               1 (2%)                                
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Spleen                                             (50)         (49)         (48)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                                               1 (2%)                                
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  4 (8%)                                                                       
   Thymus                                             (49)         (49)         (50)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Thymoma Malignant                                1 (2%)                                                                       
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 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoacanthoma                                                1 (2%)                                                          
      Carcinoma                                                     2 (4%)                    1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Mast Cell Tumor Malignant                        1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma                                               1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma             4 (8%)                                                                       
      Subcutaneous Tissue, Liposarcoma                              1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     4 (8%)       1 (2%)       3 (6%)       2 (4%)                                
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteoma                                          1 (2%)                                                                       
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                    (5)          (2)          (4)          (1)                                    
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Glandular                                                              1 (25%)                                            
      Rhabdomyosarcoma                                                           1 (25%)                                            
      Sarcoma                                          2 (40%)      1 (50%)                                                         
      Sarcoma, Metastatic, Skin                        1 (20%)                   1 (25%)                                            
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                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/31/03  
Route: DOSED WATER                                                                                                Time: 10:54:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Cranial Nerve, Schwannoma Malignant                                                     1 (2%)                                
   Spinal Cord                                        (4)          (4)          (2)          (1)                                    
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     6 (12%)      2 (4%)                    3 (6%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       2 (4%)       3 (6%)                                             
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (2%)                    2 (4%)                                             
      Sarcoma, Metastatic, Skeletal Muscle             1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)         (50)                                   
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (48)         (50)         (50)         (50)                                   
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                          3 (6%)       5 (10%)      2 (4%)       3 (6%)                                
      Carcinoma                                        1 (2%)       2 (4%)       1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)                                   
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Urinary Bladder                                    (50)         (49)         (48)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/31/03  
Route: DOSED WATER                                                                                                Time: 10:54:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
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 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)       1 (2%)                                
      Lymphoma Malignant                              29 (58%)     30 (60%)     16 (32%)     23 (46%)                               
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96018-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                        WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                   Date: 03/31/03  
Route: DOSED WATER                                                                                                Time: 10:54:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       175 MG/L     350 MG/L     700 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          44          37          43                                       
     Total Primary Neoplasms                          128          89          71          74                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 34          25          24          28                                       
     Total Benign Neoplasms                            52          35          29          31                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              43          38          31          35                                       
     Total Malignant Neoplasms                         76          54          42          43                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           2           9           2                                       
     Total Metastatic Neoplasm                         16           3          20           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
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