National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/16491

TDMS Study 96018-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 DATE: 03/25/03       
EXPERIMENT: 96018 TEST: 04                                                                                     TIME: 10:56:39       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96018       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 75-27-4         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 DATE: 03/25/03       
EXPERIMENT: 96018 TEST: 04                                                                                     TIME: 10:56:39       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96018       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 75-27-4         
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Brain                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pituitary Gland                                                                    
                                                 Salivary Glands                                                                    
                                                 Spleen                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 DATE: 03/25/03       
EXPERIMENT: 96018 TEST: 04                                                                                     TIME: 10:56:39       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96018       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 75-27-4         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF  WATER DISINFECTION BYPRODUCTS (BROMODICHL                                                                       
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Bone Marrow                            Hemangiosarcoma                                                                              
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatoblastoma                                                   
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
Pituitary Gland: Pars Intermedia       Adenoma                                                                                      
Skin                                   Hemangiosarcoma                                                                              
Spleen                                 Hemangiosarcoma                                                                              
Uterus                                 Hemangiosarcoma                                                                              
                                       Sarcoma Stromal                                                                              
All Organs                             Hemangiosarcoma                                                                              
                                       Hemangiosarcoma or Hemangioma                                                                
                                       Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type      
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -   WATER DISINFECTION BYPRODUCTS (BROMODICHL    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.47                  0/43.54                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/36 (6%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.113N                 P=0.238N                 P=0.258N                 P=0.221N        | 
|POLY 3             |                  P=0.111N                 P=0.247N                 P=0.247N                 P=0.237N        | 
|POLY 1.5           |                  P=0.112N                 P=0.244N                 P=0.243N                 P=0.237N        | 
|POLY 6             |                  P=0.111N                 P=0.251N                 P=0.252N                 P=0.237N        | 
|LOGISTIC REGRESSION|                  P=0.113N                 (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.115N                 P=0.247N                 P=0.247N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.029N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                5/50 (10%)               2/50 (4%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  3/45.58                  5/44.03                  2/43.59                  3/45.46         | 
|POLY-3 PERCENT (g) |                  6.6%                     11.4%                    4.6%                     6.6%            | 
|TERMINAL (d)       |                  2/36 (6%)                4/36 (11%)               1/33 (3%)                3/39 (8%)       | 
|FIRST INCIDENCE    |                  702                      581                      701                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.414N                 P=0.346                  P=0.549N                 P=0.633N        | 
|POLY 3             |                  P=0.445N                 P=0.337                  P=0.520N                 P=0.661         | 
|POLY 1.5           |                  P=0.443N                 P=0.343                  P=0.512N                 P=0.662         | 
|POLY 6             |                  P=0.447N                 P=0.331                  P=0.531N                 P=0.660         | 
|LOGISTIC REGRESSION|                  P=0.437N                 P=0.339                  P=0.529N                 P=0.663N        | 
|COCH-ARM / FISHERS |                  P=0.442N                 P=0.357                  P=0.500N                 P=0.661N        | 
|ORDER RESTRICTED   |                  P=0.427N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)                1/50 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/45.47                  2/43.97                  1/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  2.2%                     4.6%                     2.3%                     0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                1/36 (3%)                1/33 (3%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  604                      729 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.240N                 P=0.495                  P=0.742                  P=0.484N        | 
|POLY 3             |                  P=0.249N                 P=0.488                  P=0.751                  P=0.500N        | 
|POLY 1.5           |                  P=0.249N                 P=0.492                  P=0.755                  P=0.500N        | 
|POLY 6             |                  P=0.250N                 P=0.485                  P=0.746                  P=0.500N        | 
|LOGISTIC REGRESSION|                  P=0.247N                 P=0.503                  P=0.742                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.247N                 P=0.500                  P=0.753N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.217N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/50 (8%)                7/50 (14%)               3/50 (6%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  4/45.58                  7/44.46                  3/43.59                  3/45.46         | 
|POLY-3 PERCENT (g) |                  8.8%                     15.7%                    6.9%                     6.6%            | 
|TERMINAL (d)       |                  3/36 (8%)                5/36 (14%)               2/33 (6%)                3/39 (8%)       | 
|FIRST INCIDENCE    |                  702                      581                      701                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.239N                 P=0.255                  P=0.556N                 P=0.465N        | 
|POLY 3             |                  P=0.262N                 P=0.246                  P=0.524N                 P=0.501N        | 
|POLY 1.5           |                  P=0.260N                 P=0.250                  P=0.514N                 P=0.500N        | 
|POLY 6             |                  P=0.265N                 P=0.242                  P=0.537N                 P=0.503N        | 
|LOGISTIC REGRESSION|                  P=0.257N                 P=0.249                  P=0.542N                 P=0.499N        | 
|COCH-ARM / FISHERS |                  P=0.260N                 P=0.262                  P=0.500N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.283N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/49 (6%)                1/48 (2%)                1/48 (2%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  3/44.91                  1/42.54                  1/41.70                  2/45.10         | 
|POLY-3 PERCENT (g) |                  6.7%                     2.4%                     2.4%                     4.4%            | 
|TERMINAL (d)       |                  3/36 (8%)                1/36 (3%)                1/33 (3%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.445N                 P=0.305N                 P=0.336N                 P=0.463N        | 
|POLY 3             |                  P=0.469N                 P=0.325N                 P=0.332N                 P=0.498N        | 
|POLY 1.5           |                  P=0.469N                 P=0.321N                 P=0.324N                 P=0.498N        | 
|POLY 6             |                  P=0.469N                 P=0.329N                 P=0.342N                 P=0.499N        | 
|LOGISTIC REGRESSION|                  P=0.445N                 P=0.305N                 P=0.336N                 P=0.463N        | 
|COCH-ARM / FISHERS |                  P=0.472N                 P=0.316N                 P=0.316N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.301N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/49 (6%)                1/48 (2%)                1/48 (2%)                3/49 (6%)       | 
|POLY-3 RATE (b)    |                  3/44.91                  1/42.54                  1/41.70                  3/45.45         | 
|POLY-3 PERCENT (g) |                  6.7%                     2.4%                     2.4%                     6.6%            | 
|TERMINAL (d)       |                  3/36 (8%)                1/36 (3%)                1/33 (3%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  631             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.530                  P=0.305N                 P=0.336N                 P=0.629N        | 
|POLY 3             |                  P=0.510                  P=0.325N                 P=0.332N                 P=0.657N        | 
|POLY 1.5           |                  P=0.508                  P=0.321N                 P=0.324N                 P=0.658N        | 
|POLY 6             |                  P=0.513                  P=0.329N                 P=0.342N                 P=0.655N        | 
|LOGISTIC REGRESSION|                  P=0.506                  P=0.305N                 P=0.336N                 P=0.662N        | 
|COCH-ARM / FISHERS |                  P=0.502                  P=0.316N                 P=0.316N                 P=0.661N        | 
|ORDER RESTRICTED   |                  P=0.408N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.91                  1/43.54                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     2.3%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                1/36 (3%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  604                      729 (T)                  ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.100N                 P=0.505N                 P=0.254N                 P=0.233N        | 
|POLY 3             |                  P=0.100N                 P=0.518N                 P=0.249N                 P=0.239N        | 
|POLY 1.5           |                  P=0.100N                 P=0.512N                 P=0.244N                 P=0.238N        | 
|POLY 6             |                  P=0.101N                 P=0.526N                 P=0.256N                 P=0.241N        | 
|LOGISTIC REGRESSION|                  P=0.100N                 P=0.497N                 P=0.226N                 P=0.241N        | 
|COCH-ARM / FISHERS |                  P=0.101N                 P=0.500N                 P=0.247N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.075N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  24/50 (48%)              18/50 (36%)              19/50 (38%)              16/50 (32%)     | 
|POLY-3 RATE (b)    |                  24/45.90                 18/44.38                 19/45.29                 16/45.73        | 
|POLY-3 PERCENT (g) |                  52.3%                    40.6%                    42.0%                    35.0%           | 
|TERMINAL (d)       |                  20/36 (56%)              16/36 (44%)              12/33 (36%)              14/39 (36%)     | 
|FIRST INCIDENCE    |                  649                      521                      539                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.063N                 P=0.165N                 P=0.346N                 P=0.047N*       | 
|POLY 3             |                  P=0.074N                 P=0.179N                 P=0.215N                 P=0.068N        | 
|POLY 1.5           |                  P=0.077N                 P=0.172N                 P=0.214N                 P=0.070N        | 
|POLY 6             |                  P=0.070N                 P=0.191N                 P=0.213N                 P=0.067N        | 
|LOGISTIC REGRESSION|                  P=0.078N                 P=0.214N                 P=0.270N                 P=0.067N        | 
|COCH-ARM / FISHERS |                  P=0.088N                 P=0.156N                 P=0.210N                 P=0.076N        | 
|ORDER RESTRICTED   |                  P=0.065N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  13/50 (26%)              6/50 (12%)               12/50 (24%)              7/50 (14%)      | 
|POLY-3 RATE (b)    |                  13/46.14                 6/44.32                  12/45.45                 7/45.73         | 
|POLY-3 PERCENT (g) |                  28.2%                    13.5%                    26.4%                    15.3%           | 
|TERMINAL (d)       |                  9/36 (25%)               4/36 (11%)               6/33 (18%)               5/39 (13%)      | 
|FIRST INCIDENCE    |                  604                      547                      539                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.166N                 P=0.078N                 P=0.581                  P=0.092N        | 
|POLY 3             |                  P=0.170N                 P=0.071N                 P=0.518N                 P=0.106N        | 
|POLY 1.5           |                  P=0.171N                 P=0.068N                 P=0.512N                 P=0.105N        | 
|POLY 6             |                  P=0.168N                 P=0.076N                 P=0.522N                 P=0.107N        | 
|LOGISTIC REGRESSION|                  P=0.177N                 P=0.071N                 P=0.515N                 P=0.104N        | 
|COCH-ARM / FISHERS |                  P=0.180N                 P=0.062N                 P=0.500N                 P=0.105N        | 
|ORDER RESTRICTED   |                  P=0.094N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  14/50 (28%)              6/50 (12%)               12/50 (24%)              8/50 (16%)      | 
|POLY-3 RATE (b)    |                  14/46.56                 6/44.32                  12/45.45                 8/45.73         | 
|POLY-3 PERCENT (g) |                  30.1%                    13.5%                    26.4%                    17.5%           | 
|TERMINAL (d)       |                  9/36 (25%)               4/36 (11%)               6/33 (18%)               6/39 (15%)      | 
|FIRST INCIDENCE    |                  604                      547                      539                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.185N                 P=0.054N                 P=0.506N                 P=0.101N        | 
|POLY 3             |                  P=0.194N                 P=0.047N*                P=0.437N                 P=0.119N        | 
|POLY 1.5           |                  P=0.194N                 P=0.044N*                P=0.427N                 P=0.115N        | 
|POLY 6             |                  P=0.195N                 P=0.052N                 P=0.448N                 P=0.124N        | 
|LOGISTIC REGRESSION|                  P=0.199N                 P=0.044N*                P=0.416N                 P=0.113N        | 
|COCH-ARM / FISHERS |                  P=0.201N                 P=0.039N*                P=0.410N                 P=0.114N        | 
|ORDER RESTRICTED   |                  P=0.105N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  30/50 (60%)              23/50 (46%)              24/50 (48%)              19/50 (38%)     | 
|POLY-3 RATE (b)    |                  30/46.49                 23/44.96                 24/45.78                 19/45.73        | 
|POLY-3 PERCENT (g) |                  64.5%                    51.2%                    52.4%                    41.6%           | 
|TERMINAL (d)       |                  24/36 (67%)              20/36 (56%)              16/33 (49%)              17/39 (44%)     | 
|FIRST INCIDENCE    |                  604                      521                      539                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.019N*                P=0.133N                 P=0.316N                 P=0.012N*       | 
|POLY 3             |                  P=0.022N*                P=0.134N                 P=0.162N                 P=0.019N*       | 
|POLY 1.5           |                  P=0.022N*                P=0.127N                 P=0.160N                 P=0.019N*       | 
|POLY 6             |                  P=0.022N*                P=0.148N                 P=0.162N                 P=0.020N*       | 
|LOGISTIC REGRESSION|                  P=0.022N*                P=0.159N                 P=0.208N                 P=0.018N*       | 
|COCH-ARM / FISHERS |                  P=0.028N*                P=0.115N                 P=0.158N                 P=0.022N*       | 
|ORDER RESTRICTED   |                  P=0.015N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  31/50 (62%)              23/50 (46%)              24/50 (48%)              19/50 (38%)     | 
|POLY-3 RATE (b)    |                  31/46.91                 23/44.96                 24/45.78                 19/45.73        | 
|POLY-3 PERCENT (g) |                  66.1%                    51.2%                    52.4%                    41.6%           | 
|TERMINAL (d)       |                  24/36 (67%)              20/36 (56%)              16/33 (49%)              17/39 (44%)     | 
|FIRST INCIDENCE    |                  604                      521                      539                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.013N*                P=0.101N                 P=0.260N                 P=0.008N**      | 
|POLY 3             |                  P=0.015N*                P=0.102N                 P=0.125N                 P=0.012N*       | 
|POLY 1.5           |                  P=0.015N*                P=0.093N                 P=0.120N                 P=0.012N*       | 
|POLY 6             |                  P=0.016N*                P=0.121N                 P=0.133N                 P=0.015N*       | 
|LOGISTIC REGRESSION|                  P=0.015N*                P=0.110N                 P=0.149N                 P=0.011N*       | 
|COCH-ARM / FISHERS |                  P=0.019N*                P=0.080N                 P=0.114N                 P=0.014N*       | 
|ORDER RESTRICTED   |                  P=0.010N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/50 (12%)               2/50 (4%)                0/50 (0%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  6/45.53                  2/43.54                  0/43.48                  3/46.27         | 
|POLY-3 PERCENT (g) |                  13.2%                    4.6%                     0.0%                     6.5%            | 
|TERMINAL (d)       |                  5/36 (14%)               2/36 (6%)                0/33 (0%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  715                      729 (T)                  ---                      424             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.172N                 P=0.139N                 P=0.025N*                P=0.215N        | 
|POLY 3             |                  P=0.178N                 P=0.147N                 P=0.018N*                P=0.234N        | 
|POLY 1.5           |                  P=0.179N                 P=0.143N                 P=0.017N*                P=0.236N        | 
|POLY 6             |                  P=0.176N                 P=0.153N                 P=0.019N*                P=0.232N        | 
|LOGISTIC REGRESSION|                  P=0.186N                 P=0.157N                 P=0.024N*                P=0.243N        | 
|COCH-ARM / FISHERS |                  P=0.186N                 P=0.134N                 P=0.013N*                P=0.243N        | 
|ORDER RESTRICTED   |                  P=0.031N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)                2/50 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/45.47                  2/43.54                  2/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  2.2%                     4.6%                     4.6%                     0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                2/36 (6%)                2/33 (6%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.279N                 P=0.500                  P=0.470                  P=0.484N        | 
|POLY 3             |                  P=0.295N                 P=0.485                  P=0.484                  P=0.500N        | 
|POLY 1.5           |                  P=0.295N                 P=0.490                  P=0.491                  P=0.500N        | 
|POLY 6             |                  P=0.295N                 P=0.479                  P=0.476                  P=0.500N        | 
|LOGISTIC REGRESSION|                  P=0.279N                 P=0.500                  P=0.470                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.296N                 P=0.500                  P=0.500                  P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.213N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/50 (12%)               4/50 (8%)                2/50 (4%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  6/45.53                  4/43.54                  2/43.48                  3/46.27         | 
|POLY-3 PERCENT (g) |                  13.2%                    9.2%                     4.6%                     6.5%            | 
|TERMINAL (d)       |                  5/36 (14%)               4/36 (11%)               2/33 (6%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  715                      729 (T)                  729 (T)                  424             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.151N                 P=0.376N                 P=0.169N                 P=0.215N        | 
|POLY 3             |                  P=0.162N                 P=0.398N                 P=0.148N                 P=0.234N        | 
|POLY 1.5           |                  P=0.164N                 P=0.389N                 P=0.142N                 P=0.236N        | 
|POLY 6             |                  P=0.160N                 P=0.409N                 P=0.156N                 P=0.232N        | 
|LOGISTIC REGRESSION|                  P=0.169N                 P=0.416N                 P=0.172N                 P=0.243N        | 
|COCH-ARM / FISHERS |                  P=0.170N                 P=0.370N                 P=0.134N                 P=0.243N        | 
|ORDER RESTRICTED   |                  P=0.142N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  2/44.75                  0/43.48                  1/45.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.5%                     0.0%                     2.2%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  ---                      521                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.541                  P=0.235                  (e)                      P=0.516         | 
|POLY 3             |                  P=0.537                  P=0.234                  (e)                      P=0.500         | 
|POLY 1.5           |                  P=0.538                  P=0.234                  (e)                      P=0.500         | 
|POLY 6             |                  P=0.535                  P=0.233                  (e)                      P=0.500         | 
|LOGISTIC REGRESSION|                  P=0.508                  P=0.309                  (e)                      P=0.516         | 
|COCH-ARM / FISHERS |                  P=0.539                  P=0.247                  (e)                      P=0.500         | 
|ORDER RESTRICTED   |                  P=0.318                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/50 (8%)                1/49 (2%)                1/50 (2%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  4/45.64                  1/42.75                  1/43.74                  1/44.46         | 
|POLY-3 PERCENT (g) |                  8.8%                     2.3%                     2.3%                     2.3%            | 
|TERMINAL (d)       |                  2/36 (6%)                0/35 (0%)                0/33 (0%)                1/38 (3%)       | 
|FIRST INCIDENCE    |                  702                      674                      659                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.137N                 P=0.207N                 P=0.219N                 P=0.177N        | 
|POLY 3             |                  P=0.134N                 P=0.199N                 P=0.192N                 P=0.187N        | 
|POLY 1.5           |                  P=0.134N                 P=0.195N                 P=0.187N                 P=0.186N        | 
|POLY 6             |                  P=0.133N                 P=0.204N                 P=0.198N                 P=0.188N        | 
|LOGISTIC REGRESSION|                  P=0.137N                 P=0.197N                 P=0.188N                 P=0.186N        | 
|COCH-ARM / FISHERS |                  P=0.137N                 P=0.187N                 P=0.181N                 P=0.187N        | 
|ORDER RESTRICTED   |                  P=0.082N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/49 (2%)                0/50 (0%)                4/49 (8%)       | 
|POLY-3 RATE (b)    |                  2/45.53                  1/42.97                  0/43.48                  4/44.63         | 
|POLY-3 PERCENT (g) |                  4.4%                     2.3%                     0.0%                     9.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                0/35 (0%)                0/33 (0%)                3/38 (8%)       | 
|FIRST INCIDENCE    |                  715                      604                      ---                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.181                  P=0.520N                 P=0.271N                 P=0.354         | 
|POLY 3             |                  P=0.161                  P=0.520N                 P=0.248N                 P=0.328         | 
|POLY 1.5           |                  P=0.161                  P=0.516N                 P=0.243N                 P=0.329         | 
|POLY 6             |                  P=0.161                  P=0.524N                 P=0.253N                 P=0.328         | 
|LOGISTIC REGRESSION|                  P=0.163                  P=0.501N                 P=0.255N                 P=0.325         | 
|COCH-ARM / FISHERS |                  P=0.161                  P=0.508N                 P=0.247N                 P=0.329         | 
|ORDER RESTRICTED   |                  P=0.074                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/49 (6%)                3/50 (6%)                1/49 (2%)                3/49 (6%)       | 
|POLY-3 RATE (b)    |                  3/44.47                  3/43.54                  1/43.66                  3/44.63         | 
|POLY-3 PERCENT (g) |                  6.8%                     6.9%                     2.3%                     6.7%            | 
|TERMINAL (d)       |                  3/35 (9%)                3/36 (8%)                0/33 (0%)                3/39 (8%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  604                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.502N                 P=0.651N                 P=0.326N                 P=0.613N        | 
|POLY 3             |                  P=0.542N                 P=0.653                  P=0.312N                 P=0.661N        | 
|POLY 1.5           |                  P=0.543N                 P=0.658                  P=0.309N                 P=0.661N        | 
|POLY 6             |                  P=0.541N                 P=0.646                  P=0.316N                 P=0.660N        | 
|LOGISTIC REGRESSION|                  P=0.538N                 P=0.651N                 P=0.306N                 P=0.613N        | 
|COCH-ARM / FISHERS |                  P=0.547N                 P=0.651N                 P=0.309N                 P=0.661N        | 
|ORDER RESTRICTED   |                  P=0.504N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/49 (4%)                0/50 (0%)                0/49 (0%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  2/44.47                  0/43.54                  0/43.23                  0/44.63         | 
|POLY-3 PERCENT (g) |                  4.5%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/35 (6%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.110N                 P=0.232N                 P=0.251N                 P=0.215N        | 
|POLY 3             |                  P=0.111N                 P=0.242N                 P=0.243N                 P=0.236N        | 
|POLY 1.5           |                  P=0.112N                 P=0.239N                 P=0.241N                 P=0.237N        | 
|POLY 6             |                  P=0.110N                 P=0.245N                 P=0.247N                 P=0.236N        | 
|LOGISTIC REGRESSION|                  P=0.110N                 (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.115N                 P=0.242N                 P=0.247N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.029N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skeletal Muscle                                                                                                                  | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.77                  1/43.54                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     2.3%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                1/36 (3%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  649                      729 (T)                  ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.100N                 P=0.511N                 P=0.252N                 P=0.233N        | 
|POLY 3             |                  P=0.100N                 P=0.517N                 P=0.249N                 P=0.239N        | 
|POLY 1.5           |                  P=0.100N                 P=0.512N                 P=0.244N                 P=0.238N        | 
|POLY 6             |                  P=0.101N                 P=0.525N                 P=0.255N                 P=0.240N        | 
|LOGISTIC REGRESSION|                  P=0.101N                 P=0.508N                 P=0.235N                 P=0.238N        | 
|COCH-ARM / FISHERS |                  P=0.101N                 P=0.500N                 P=0.247N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.075N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  5/50 (10%)               1/50 (2%)                4/50 (8%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  5/46.93                  1/43.54                  4/44.08                  4/46.42         | 
|POLY-3 PERCENT (g) |                  10.7%                    2.3%                     9.1%                     8.6%            | 
|TERMINAL (d)       |                  2/36 (6%)                1/36 (3%)                3/33 (9%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  563                      729 (T)                  539                      472             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.559                  P=0.115N                 P=0.543N                 P=0.481N        | 
|POLY 3             |                  P=0.553                  P=0.120N                 P=0.539N                 P=0.507N        | 
|POLY 1.5           |                  P=0.549                  P=0.113N                 P=0.523N                 P=0.503N        | 
|POLY 6             |                  P=0.556                  P=0.128N                 P=0.560N                 P=0.513N        | 
|LOGISTIC REGRESSION|                  P=0.522                  P=0.085N                 P=0.464N                 P=0.515N        | 
|COCH-ARM / FISHERS |                  P=0.537                  P=0.102N                 P=0.500N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.373N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  5/50 (10%)               1/50 (2%)                4/50 (8%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  5/46.93                  1/43.54                  4/44.08                  4/46.42         | 
|POLY-3 PERCENT (g) |                  10.7%                    2.3%                     9.1%                     8.6%            | 
|TERMINAL (d)       |                  2/36 (6%)                1/36 (3%)                3/33 (9%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  563                      729 (T)                  539                      472             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.559                  P=0.115N                 P=0.543N                 P=0.481N        | 
|POLY 3             |                  P=0.553                  P=0.120N                 P=0.539N                 P=0.507N        | 
|POLY 1.5           |                  P=0.549                  P=0.113N                 P=0.523N                 P=0.503N        | 
|POLY 6             |                  P=0.556                  P=0.128N                 P=0.560N                 P=0.513N        | 
|LOGISTIC REGRESSION|                  P=0.522                  P=0.085N                 P=0.464N                 P=0.515N        | 
|COCH-ARM / FISHERS |                  P=0.537                  P=0.102N                 P=0.500N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.373N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/50 (8%)                0/50 (0%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  4/45.91                  0/43.54                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  8.7%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  3/36 (8%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  604                      ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.021N*                P=0.066N                 P=0.075N                 P=0.058N        | 
|POLY 3             |                  P=0.017N*                P=0.067N                 P=0.067N                 P=0.061N        | 
|POLY 1.5           |                  P=0.017N*                P=0.065N                 P=0.065N                 P=0.061N        | 
|POLY 6             |                  P=0.017N*                P=0.070N                 P=0.071N                 P=0.062N        | 
|LOGISTIC REGRESSION|                  P=0.020N*                P=0.064N                 P=0.064N                 P=0.063N        | 
|COCH-ARM / FISHERS |                  P=0.020N*                P=0.059N                 P=0.059N                 P=0.059N        | 
|ORDER RESTRICTED   |                  P=0.002N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/50 (8%)                1/50 (2%)                3/50 (6%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  4/46.93                  1/43.54                  3/44.08                  2/45.69         | 
|POLY-3 PERCENT (g) |                  8.5%                     2.3%                     6.8%                     4.4%            | 
|TERMINAL (d)       |                  1/36 (3%)                1/36 (3%)                2/33 (6%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  563                      729 (T)                  539                      669             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.361N                 P=0.194N                 P=0.535N                 P=0.334N        | 
|POLY 3             |                  P=0.367N                 P=0.202N                 P=0.534N                 P=0.350N        | 
|POLY 1.5           |                  P=0.367N                 P=0.194N                 P=0.520N                 P=0.344N        | 
|POLY 6             |                  P=0.367N                 P=0.214N                 P=0.553N                 P=0.356N        | 
|LOGISTIC REGRESSION|                  P=0.382N                 P=0.146N                 P=0.451N                 P=0.348N        | 
|COCH-ARM / FISHERS |                  P=0.371N                 P=0.181N                 P=0.500N                 P=0.339N        | 
|ORDER RESTRICTED   |                  P=0.300N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/50 (8%)                0/49 (0%)                0/48 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  4/45.47                  0/43.17                  0/41.61                  0/45.46         | 
|POLY-3 PERCENT (g) |                  8.8%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  4/36 (11%)               0/36 (0%)                0/32 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.020N*                P=0.063N                 P=0.078N                 P=0.053N        | 
|POLY 3             |                  P=0.018N*                P=0.067N                 P=0.072N                 P=0.060N        | 
|POLY 1.5           |                  P=0.018N*                P=0.066N                 P=0.070N                 P=0.060N        | 
|POLY 6             |                  P=0.018N*                P=0.068N                 P=0.075N                 P=0.060N        | 
|LOGISTIC REGRESSION|                  P=0.020N*                (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.021N*                P=0.061N                 P=0.064N                 P=0.059N        | 
|ORDER RESTRICTED   |                  P=0.002N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                0/50 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  2/44.03                  0/43.48                  2/45.81         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.5%                     0.0%                     4.4%            | 
|TERMINAL (d)       |                  0/36 (0%)                1/36 (3%)                0/33 (0%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  ---                      581                      ---                      631             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.263                  P=0.235                  (e)                      P=0.251         | 
|POLY 3             |                  P=0.247                  P=0.230                  (e)                      P=0.239         | 
|POLY 1.5           |                  P=0.247                  P=0.232                  (e)                      P=0.238         | 
|POLY 6             |                  P=0.247                  P=0.228                  (e)                      P=0.240         | 
|LOGISTIC REGRESSION|                  P=0.239                  P=0.251                  (e)                      P=0.236         | 
|COCH-ARM / FISHERS |                  P=0.247                  P=0.247                  (e)                      P=0.247         | 
|ORDER RESTRICTED   |                  P=0.117                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                1/50 (2%)                0/50 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  1/44.03                  0/43.48                  2/45.81         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.3%                     0.0%                     4.4%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  ---                      581                      ---                      631             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.150                  P=0.491                  (e)                      P=0.251         | 
|POLY 3             |                  P=0.140                  P=0.494                  (e)                      P=0.239         | 
|POLY 1.5           |                  P=0.140                  P=0.495                  (e)                      P=0.238         | 
|POLY 6             |                  P=0.141                  P=0.492                  (e)                      P=0.240         | 
|LOGISTIC REGRESSION|                  P=0.127                  P=0.551                  (e)                      P=0.236         | 
|COCH-ARM / FISHERS |                  P=0.140                  P=0.500                  (e)                      P=0.247         | 
|ORDER RESTRICTED   |                  P=0.075                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/49 (0%)                1/49 (2%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/45.91                  0/42.54                  1/42.61                  1/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     2.4%                     2.2%            | 
|TERMINAL (d)       |                  1/36 (3%)                0/35 (0%)                1/33 (3%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  604                      ---                      729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.482N                 P=0.248N                 P=0.525N                 P=0.484N        | 
|POLY 3             |                  P=0.492N                 P=0.254N                 P=0.526N                 P=0.503N        | 
|POLY 1.5           |                  P=0.494N                 P=0.250N                 P=0.518N                 P=0.501N        | 
|POLY 6             |                  P=0.490N                 P=0.260N                 P=0.536N                 P=0.506N        | 
|LOGISTIC REGRESSION|                  P=0.498N                 P=0.229N                 P=0.504N                 P=0.501N        | 
|COCH-ARM / FISHERS |                  P=0.499N                 P=0.253N                 P=0.508N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.284N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/49 (2%)                2/49 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/45.91                  1/42.54                  2/42.61                  1/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     2.4%                     4.7%                     2.2%            | 
|TERMINAL (d)       |                  1/36 (3%)                1/35 (3%)                2/33 (6%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  604                      729 (T)                  729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.421N                 P=0.512N                 P=0.666                  P=0.484N        | 
|POLY 3             |                  P=0.440N                 P=0.527N                 P=0.667                  P=0.503N        | 
|POLY 1.5           |                  P=0.440N                 P=0.520N                 P=0.675                  P=0.501N        | 
|POLY 6             |                  P=0.439N                 P=0.535N                 P=0.657                  P=0.506N        | 
|LOGISTIC REGRESSION|                  P=0.440N                 P=0.505N                 P=0.685                  P=0.501N        | 
|COCH-ARM / FISHERS |                  P=0.443N                 P=0.508N                 P=0.684                  P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.447N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.63                  0/43.54                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  689                      ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.117N                 P=0.251N                 P=0.264N                 P=0.234N        | 
|POLY 3             |                  P=0.111N                 P=0.248N                 P=0.248N                 P=0.238N        | 
|POLY 1.5           |                  P=0.112N                 P=0.244N                 P=0.244N                 P=0.237N        | 
|POLY 6             |                  P=0.110N                 P=0.252N                 P=0.254N                 P=0.239N        | 
|LOGISTIC REGRESSION|                  P=0.116N                 P=0.245N                 P=0.245N                 P=0.237N        | 
|COCH-ARM / FISHERS |                  P=0.115N                 P=0.247N                 P=0.247N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.030N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.47                  0/43.54                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/36 (6%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.113N                 P=0.238N                 P=0.258N                 P=0.221N        | 
|POLY 3             |                  P=0.111N                 P=0.247N                 P=0.247N                 P=0.237N        | 
|POLY 1.5           |                  P=0.112N                 P=0.244N                 P=0.243N                 P=0.237N        | 
|POLY 6             |                  P=0.111N                 P=0.251N                 P=0.252N                 P=0.237N        | 
|LOGISTIC REGRESSION|                  P=0.113N                 (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.115N                 P=0.247N                 P=0.247N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.029N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.47                  1/43.54                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     2.3%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/36 (6%)                1/36 (3%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.097N                 P=0.500N                 P=0.258N                 P=0.221N        | 
|POLY 3             |                  P=0.100N                 P=0.515N                 P=0.247N                 P=0.237N        | 
|POLY 1.5           |                  P=0.100N                 P=0.510N                 P=0.243N                 P=0.237N        | 
|POLY 6             |                  P=0.100N                 P=0.521N                 P=0.252N                 P=0.237N        | 
|LOGISTIC REGRESSION|                  P=0.097N                 P=0.500N                 (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.101N                 P=0.500N                 P=0.247N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.074N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/50 (16%)               2/50 (4%)                0/50 (0%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  8/46.12                  2/43.97                  0/43.48                  4/45.63         | 
|POLY-3 PERCENT (g) |                  17.4%                    4.6%                     0.0%                     8.8%            | 
|TERMINAL (d)       |                  5/36 (14%)               1/36 (3%)                0/33 (0%)                3/39 (8%)       | 
|FIRST INCIDENCE    |                  604                      604                      ---                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.145N                 P=0.058N                 P=0.009N**               P=0.164N        | 
|POLY 3             |                  P=0.143N                 P=0.053N                 P=0.005N**               P=0.182N        | 
|POLY 1.5           |                  P=0.144N                 P=0.051N                 P=0.004N**               P=0.179N        | 
|POLY 6             |                  P=0.143N                 P=0.057N                 P=0.005N**               P=0.185N        | 
|LOGISTIC REGRESSION|                  P=0.150N                 P=0.050N                 P=0.005N**               P=0.177N        | 
|COCH-ARM / FISHERS |                  P=0.151N                 P=0.046N*                P=0.003N**               P=0.178N        | 
|ORDER RESTRICTED   |                  P=0.012N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/50 (16%)               3/50 (6%)                1/50 (2%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  8/46.12                  3/43.97                  1/43.48                  4/45.63         | 
|POLY-3 PERCENT (g) |                  17.4%                    6.8%                     2.3%                     8.8%            | 
|TERMINAL (d)       |                  5/36 (14%)               2/36 (6%)                1/33 (3%)                3/39 (8%)       | 
|FIRST INCIDENCE    |                  604                      604                      729 (T)                  686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.137N                 P=0.116N                 P=0.029N*                P=0.164N        | 
|POLY 3             |                  P=0.140N                 P=0.113N                 P=0.020N*                P=0.182N        | 
|POLY 1.5           |                  P=0.140N                 P=0.109N                 P=0.018N*                P=0.179N        | 
|POLY 6             |                  P=0.140N                 P=0.120N                 P=0.022N*                P=0.185N        | 
|LOGISTIC REGRESSION|                  P=0.144N                 P=0.106N                 P=0.020N*                P=0.177N        | 
|COCH-ARM / FISHERS |                  P=0.145N                 P=0.100N                 P=0.015N*                P=0.178N        | 
|ORDER RESTRICTED   |                  P=0.030N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                1/50 (2%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  2/43.75                  1/43.71                  1/46.10         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.6%                     2.3%                     2.2%            | 
|TERMINAL (d)       |                  0/36 (0%)                1/36 (3%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  ---                      674                      669                      522             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.508                  P=0.232                  P=0.475                  P=0.500         | 
|POLY 3             |                  P=0.506                  P=0.229                  P=0.492                  P=0.503         | 
|POLY 1.5           |                  P=0.504                  P=0.231                  P=0.495                  P=0.502         | 
|POLY 6             |                  P=0.508                  P=0.226                  P=0.488                  P=0.504         | 
|LOGISTIC REGRESSION|                  P=0.486                  P=0.233                  P=0.508                  P=0.438         | 
|COCH-ARM / FISHERS |                  P=0.500                  P=0.247                  P=0.500                  P=0.500         | 
|ORDER RESTRICTED   |                  P=0.260                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  29/50 (58%)              30/50 (60%)              16/50 (32%)              23/50 (46%)     | 
|POLY-3 RATE (b)    |                  29/46.58                 30/46.20                 16/44.51                 23/46.21        | 
|POLY-3 PERCENT (g) |                  62.3%                    64.9%                    35.9%                    49.8%           | 
|TERMINAL (d)       |                  23/36 (64%)              22/36 (61%)              12/33 (36%)              21/39 (54%)     | 
|FIRST INCIDENCE    |                  563                      547                      539                      535             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.040N*                P=0.463                  P=0.029N*                P=0.096N        | 
|POLY 3             |                  P=0.050N                 P=0.479                  P=0.008N**               P=0.154N        | 
|POLY 1.5           |                  P=0.049N*                P=0.474                  P=0.007N**               P=0.152N        | 
|POLY 6             |                  P=0.055N                 P=0.496                  P=0.010N*                P=0.161N        | 
|LOGISTIC REGRESSION|                  P=0.048N*                P=0.410                  P=0.012N*                P=0.151N        | 
|COCH-ARM / FISHERS |                  P=0.057N                 P=0.500                  P=0.008N**               P=0.158N        | 
|ORDER RESTRICTED   |                  P=0.026N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  34/50 (68%)              25/50 (50%)              24/50 (48%)              28/50 (56%)     | 
|POLY-3 RATE (b)    |                  34/46.44                 25/44.88                 24/45.72                 28/46.89        | 
|POLY-3 PERCENT (g) |                  73.2%                    55.7%                    52.5%                    59.7%           | 
|TERMINAL (d)       |                  28/36 (78%)              22/36 (61%)              16/33 (49%)              24/39 (62%)     | 
|FIRST INCIDENCE    |                  604                      521                      539                      424             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.140N                 P=0.060N                 P=0.119N                 P=0.083N        | 
|POLY 3             |                  P=0.160N                 P=0.056N                 P=0.028N*                P=0.116N        | 
|POLY 1.5           |                  P=0.174N                 P=0.054N                 P=0.029N*                P=0.124N        | 
|POLY 6             |                  P=0.149N                 P=0.061N                 P=0.026N*                P=0.111N        | 
|LOGISTIC REGRESSION|                  P=0.191N                 P=0.078N                 P=0.050N                 P=0.142N        | 
|COCH-ARM / FISHERS |                  P=0.214N                 P=0.052N                 P=0.034N*                P=0.151N        | 
|ORDER RESTRICTED   |                  P=0.057N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -   WATER DISINFECTION BYPRODUCTS (BROMODICHL     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  43/50 (86%)              38/50 (76%)              32/50 (64%)              35/50 (70%)     | 
|POLY-3 RATE (b)    |                  43/48.28                 38/47.47                 32/47.98                 35/48.42        | 
|POLY-3 PERCENT (g) |                  89.1%                    80.0%                    66.7%                    72.3%           | 
|TERMINAL (d)       |                  32/36 (89%)              27/36 (75%)              19/33 (58%)              27/39 (69%)     | 
|FIRST INCIDENCE    |                  563                      521                      323                      472             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.053N                 P=0.285N                 P=0.133N                 P=0.049N*       | 
|POLY 3             |                  P=0.024N*                P=0.170N                 P=0.006N**               P=0.029N*       | 
|POLY 1.5           |                  P=0.025N*                P=0.168N                 P=0.006N**               P=0.030N*       | 
|POLY 6             |                  P=0.027N*                P=0.172N                 P=0.007N**               P=0.033N*       | 
|LOGISTIC REGRESSION|                  P=0.035N*                P=0.209N                 P=0.013N*                P=0.041N*       | 
|COCH-ARM / FISHERS |                  P=0.041N*                P=0.154N                 P=0.010N*                P=0.045N*       | 
|ORDER RESTRICTED   |                  P=0.012N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                  #                        #                        #                        #               | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  46/50 (92%)              44/50 (88%)              38/50 (76%)              43/50 (86%)     | 
|POLY-3 RATE (b)    |                  46/48.28                 44/47.47                 38/48.49                 43/49.22        | 
|POLY-3 PERCENT (g) |                  95.3%                    92.7%                    78.4%                    87.4%           | 
|TERMINAL (d)       |                  35/36 (97%)              33/36 (92%)              23/33 (70%)              34/39 (87%)     | 
|FIRST INCIDENCE    |                  563                      521                      323                      424             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.164N                 P=0.480N                 P=0.282N                 P=0.175N        | 
|POLY 3             |                  P=0.087N                 P=0.457N                 P=0.012N*                P=0.142N        | 
|POLY 1.5           |                  P=0.103N                 P=0.442N                 P=0.014N*                P=0.165N        | 
|POLY 6             |                  P=0.092N                 P=0.466N                 P=0.012N*                P=0.148N        | 
|LOGISTIC REGRESSION|                  P=0.164N                 P=0.522N                 P=0.036N*                P=0.243N        | 
|COCH-ARM / FISHERS |                  P=0.198N                 P=0.370N                 P=0.027N*                P=0.262N        | 
|ORDER RESTRICTED   |                  P=0.031N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.