National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/16495

TDMS Study 96018-04 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 DATE: 03/25/03       
EXPERIMENT: 96018 TEST: 04                                                                                     TIME: 11:07:23       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96018       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 75-27-4         
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                                                           FINAL #1/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst               WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 DATE: 03/25/03       
EXPERIMENT: 96018 TEST: 04                                                                                     TIME: 11:07:23       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: C96018       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 75-27-4         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF  WATER DISINFECTION BYPRODUCTS (BROMODICHL                                                                       
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Bone Marrow                            Hyperplasia                                                                                  
                                       Myelofibrosis                                                                                
Brain                                  Compression                                                                                  
Eye                                    Developmental Malformation                                                                   
                                       Inflammation Chronic                                                                         
Heart                                  Mineralization                                                                               
Intestine Large, Cecum                 Edema                                                                                        
Kidney                                 Nephropathy                                                                                  
Liver                                  Cyst                                                                                         
                                       Infarct                                                                                      
Liver: Centrilobular                   Necrosis                                                                                     
Liver: Hepatocyte                      Karyomegaly                                                                                  
Liver: Kupffer Cell                    Pigmentation                                                                                 
Mammary Gland                          Hyperplasia                                                                                  
Ovary: Granulosa Cell                  Hyperplasia                                                                                  
Spleen                                 Hematopoietic Cell Proliferation                                                             
Spleen: Lymphoid Follicle              Hyperplasia                                                                                  
Thymus                                 Atrophy                                                                                      
Thyroid Gland                          Degeneration Cystic                                                                          
Thyroid Gland: Follicular Cell         Hyperplasia                                                                                  
===============================================================                                                                     
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/50 (16%)               5/50 (10%)               5/49 (10%)               10/49 (20%)     | 
|POLY-3 RATE (b)    |                  8/46.30                  5/43.54                  5/42.79                  10/45.20        | 
|POLY-3 PERCENT (g) |                  17.3%                    11.5%                    11.7%                    22.1%           | 
|TERMINAL (d)       |                  4/36 (11%)               5/36 (14%)               3/32 (9%)                8/38 (21%)      | 
|FIRST INCIDENCE    |                  606                      729 (T)                  663                      522             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.280                  P=0.295N                 P=0.358N                 P=0.435         | 
|POLY 3             |                  P=0.236                  P=0.316N                 P=0.328N                 P=0.375         | 
|POLY 1.5           |                  P=0.236                  P=0.302N                 P=0.312N                 P=0.379         | 
|POLY 6             |                  P=0.236                  P=0.337N                 P=0.350N                 P=0.368         | 
|LOGISTIC REGRESSION|                  P=0.235                  P=0.301N                 P=0.308N                 P=0.379         | 
|COCH-ARM / FISHERS |                  P=0.230                  P=0.277N                 P=0.290N                 P=0.379         | 
|ORDER RESTRICTED   |                  P=0.199                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)                2/49 (4%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  1/45.47                  1/43.54                  2/42.48                  0/44.46         | 
|POLY-3 PERCENT (g) |                  2.2%                     2.3%                     4.7%                     0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                1/36 (3%)                2/32 (6%)                0/38 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.357N                 P=0.762                  P=0.459                  P=0.489N        | 
|POLY 3             |                  P=0.370N                 P=0.751                  P=0.476                  P=0.504N        | 
|POLY 1.5           |                  P=0.371N                 P=0.754                  P=0.483                  P=0.504N        | 
|POLY 6             |                  P=0.370N                 P=0.747                  P=0.468                  P=0.505N        | 
|LOGISTIC REGRESSION|                  P=0.357N                 P=0.762                  P=0.459                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.373N                 P=0.753N                 P=0.492                  P=0.505N        | 
|ORDER RESTRICTED   |                  P=0.261N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Zona Reticularis                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                1/49 (2%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  2/43.54                  1/42.91                  0/44.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.6%                     2.3%                     0.0%            | 
|TERMINAL (d)       |                  0/36 (0%)                2/36 (6%)                0/32 (0%)                0/38 (0%)       | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  604                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.455N                 P=0.238                  P=0.491                  (e)             | 
|POLY 3             |                  P=0.471N                 P=0.227                  P=0.488                  (e)             | 
|POLY 1.5           |                  P=0.469N                 P=0.231                  P=0.491                  (e)             | 
|POLY 6             |                  P=0.474N                 P=0.224                  P=0.485                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.467N                 P=0.238                  P=0.524                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.467N                 P=0.247                  P=0.495                  (e)             | 
|ORDER RESTRICTED   |                  P=0.314                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/48 (0%)                0/49 (0%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  2/45.47                  0/42.17                  0/42.48                  2/44.60         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     0.0%                     4.5%            | 
|TERMINAL (d)       |                  2/36 (6%)                0/35 (0%)                0/32 (0%)                1/38 (3%)       | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      ---                      693             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.514                  P=0.244N                 P=0.264N                 P=0.679N        | 
|POLY 3             |                  P=0.502                  P=0.254N                 P=0.253N                 P=0.687         | 
|POLY 1.5           |                  P=0.501                  P=0.252N                 P=0.248N                 P=0.687         | 
|POLY 6             |                  P=0.503                  P=0.257N                 P=0.258N                 P=0.688         | 
|LOGISTIC REGRESSION|                  P=0.498                  (e)                      (e)                      P=0.687         | 
|COCH-ARM / FISHERS |                  P=0.497                  P=0.258N                 P=0.253N                 P=0.684         | 
|ORDER RESTRICTED   |                  P=0.272                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Hyperostosis                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                3/50 (6%)                1/50 (2%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  3/43.54                  1/43.97                  1/45.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     6.9%                     2.3%                     2.2%            | 
|TERMINAL (d)       |                  0/36 (0%)                3/36 (8%)                0/33 (0%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  583                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.609                  P=0.121                  P=0.496                  P=0.516         | 
|POLY 3             |                  P=0.588                  P=0.111                  P=0.493                  P=0.500         | 
|POLY 1.5           |                  P=0.590                  P=0.114                  P=0.496                  P=0.500         | 
|POLY 6             |                  P=0.587                  P=0.108                  P=0.490                  P=0.500         | 
|LOGISTIC REGRESSION|                  P=0.592                  P=0.121                  P=0.532                  P=0.516         | 
|COCH-ARM / FISHERS |                  P=0.591                  P=0.121                  P=0.500                  P=0.500         | 
|ORDER RESTRICTED   |                  P=0.213                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  22/50 (44%)              24/50 (48%)              18/50 (36%)              11/50 (22%)     | 
|POLY-3 RATE (b)    |                  22/47.66                 24/47.88                 18/46.83                 11/45.83        | 
|POLY-3 PERCENT (g) |                  46.2%                    50.1%                    38.4%                    24.0%           | 
|TERMINAL (d)       |                  12/36 (33%)              15/36 (42%)              9/33 (27%)               9/39 (23%)      | 
|FIRST INCIDENCE    |                  563                      318                      486                      669             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.008N**               P=0.397                  P=0.410N                 P=0.019N*       | 
|POLY 3             |                  P=0.006N**               P=0.428                  P=0.291N                 P=0.019N*       | 
|POLY 1.5           |                  P=0.005N**               P=0.425                  P=0.282N                 P=0.017N*       | 
|POLY 6             |                  P=0.008N**               P=0.419                  P=0.303N                 P=0.023N*       | 
|LOGISTIC REGRESSION|                  P=0.005N**               P=0.446                  P=0.258N                 P=0.016N*       | 
|COCH-ARM / FISHERS |                  P=0.005N**               P=0.421                  P=0.270N                 P=0.016N*       | 
|ORDER RESTRICTED   |                  P=0.010N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                1/50 (2%)                1/50 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  3/45.65                  1/43.54                  1/43.71                  0/45.46         | 
|POLY-3 PERCENT (g) |                  6.6%                     2.3%                     2.3%                     0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                1/36 (3%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  689                      729 (T)                  669                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.075N                 P=0.319N                 P=0.349N                 P=0.118N        | 
|POLY 3             |                  P=0.071N                 P=0.322N                 P=0.321N                 P=0.119N        | 
|POLY 1.5           |                  P=0.071N                 P=0.317N                 P=0.315N                 P=0.119N        | 
|POLY 6             |                  P=0.070N                 P=0.330N                 P=0.329N                 P=0.120N        | 
|LOGISTIC REGRESSION|                  P=0.073N                 P=0.324N                 P=0.312N                 P=0.120N        | 
|COCH-ARM / FISHERS |                  P=0.073N                 P=0.309N                 P=0.309N                 P=0.121N        | 
|ORDER RESTRICTED   |                  P=0.037N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.47                  0/43.54                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/36 (6%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.113N                 P=0.238N                 P=0.258N                 P=0.221N        | 
|POLY 3             |                  P=0.111N                 P=0.247N                 P=0.247N                 P=0.237N        | 
|POLY 1.5           |                  P=0.112N                 P=0.244N                 P=0.243N                 P=0.237N        | 
|POLY 6             |                  P=0.111N                 P=0.251N                 P=0.252N                 P=0.237N        | 
|LOGISTIC REGRESSION|                  P=0.113N                 (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.115N                 P=0.247N                 P=0.247N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.029N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                1/50 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  2/44.04                  1/43.61                  0/45.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.5%                     2.3%                     0.0%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  ---                      649                      696                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.461N                 P=0.221                  P=0.480                  (e)             | 
|POLY 3             |                  P=0.464N                 P=0.230                  P=0.492                  (e)             | 
|POLY 1.5           |                  P=0.463N                 P=0.232                  P=0.495                  (e)             | 
|POLY 6             |                  P=0.466N                 P=0.228                  P=0.488                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.465N                 P=0.249                  P=0.499                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.461N                 P=0.247                  P=0.500                  (e)             | 
|ORDER RESTRICTED   |                  P=0.316                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/48 (2%)                1/49 (2%)                4/48 (8%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  1/43.91                  1/43.11                  4/41.70                  1/44.76         | 
|POLY-3 PERCENT (g) |                  2.3%                     2.3%                     9.6%                     2.2%            | 
|TERMINAL (d)       |                  1/35 (3%)                1/36 (3%)                2/31 (7%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  696                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.550                  P=0.756N                 P=0.149                  P=0.738N        | 
|POLY 3             |                  P=0.540                  P=0.757                  P=0.163                  P=0.756N        | 
|POLY 1.5           |                  P=0.538                  P=0.759                  P=0.169                  P=0.756N        | 
|POLY 6             |                  P=0.543                  P=0.753                  P=0.155                  P=0.757N        | 
|LOGISTIC REGRESSION|                  P=0.535                  P=0.756N                 P=0.154                  P=0.738N        | 
|COCH-ARM / FISHERS |                  P=0.532                  P=0.747N                 P=0.181                  P=0.747N        | 
|ORDER RESTRICTED   |                  P=0.314                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Developmental Malformation                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/48 (2%)                0/50 (0%)                0/50 (0%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  1/44.42                  0/43.54                  0/43.48                  4/45.46         | 
|POLY-3 PERCENT (g) |                  2.3%                     0.0%                     0.0%                     8.8%            | 
|TERMINAL (d)       |                  1/36 (3%)                0/36 (0%)                0/33 (0%)                4/39 (10%)      | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.035 *                P=0.500N                 P=0.517N                 P=0.204         | 
|POLY 3             |                  P=0.028 *                P=0.504N                 P=0.504N                 P=0.186         | 
|POLY 1.5           |                  P=0.028 *                P=0.500N                 P=0.500N                 P=0.188         | 
|POLY 6             |                  P=0.028 *                P=0.508N                 P=0.509N                 P=0.184         | 
|LOGISTIC REGRESSION|                  P=0.035 *                (e)                      (e)                      P=0.204         | 
|COCH-ARM / FISHERS |                  P=0.029 *                P=0.490N                 P=0.490N                 P=0.194         | 
|ORDER RESTRICTED   |                  P=0.012 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/48 (0%)                2/50 (4%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/44.42                  2/44.15                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.5%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  ---                      641                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.404N                 P=0.222                  (e)                      (e)             | 
|POLY 3             |                  P=0.411N                 P=0.236                  (e)                      (e)             | 
|POLY 1.5           |                  P=0.407N                 P=0.238                  (e)                      (e)             | 
|POLY 6             |                  P=0.414N                 P=0.234                  (e)                      (e)             | 
|LOGISTIC REGRESSION|                  P=0.399N                 P=0.278                  (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.398N                 P=0.258                  (e)                      (e)             | 
|ORDER RESTRICTED   |                  P=0.241N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/48 (0%)                0/50 (0%)                0/50 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/44.42                  0/43.54                  0/43.48                  2/45.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     4.4%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.055                  (e)                      (e)                      P=0.256         | 
|POLY 3             |                  P=0.047 *                (e)                      (e)                      P=0.242         | 
|POLY 1.5           |                  P=0.047 *                (e)                      (e)                      P=0.244         | 
|POLY 6             |                  P=0.047 *                (e)                      (e)                      P=0.241         | 
|LOGISTIC REGRESSION|                  (e)                      (e)                      (e)                      P=0.256         | 
|COCH-ARM / FISHERS |                  P=0.048 *                (e)                      (e)                      P=0.258         | 
|ORDER RESTRICTED   |                  P=0.031 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                1/50 (2%)                2/50 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  1/45.47                  1/43.54                  2/43.73                  1/45.46         | 
|POLY-3 PERCENT (g) |                  2.2%                     2.3%                     4.6%                     2.2%            | 
|TERMINAL (d)       |                  1/36 (3%)                1/36 (3%)                1/33 (3%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  663                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.610                  P=0.762                  P=0.474                  P=0.744N        | 
|POLY 3             |                  P=0.596                  P=0.751                  P=0.486                  P=0.761         | 
|POLY 1.5           |                  P=0.595                  P=0.754                  P=0.492                  P=0.760N        | 
|POLY 6             |                  P=0.598                  P=0.747                  P=0.480                  P=0.760         | 
|LOGISTIC REGRESSION|                  P=0.593                  P=0.762                  P=0.489                  P=0.744N        | 
|COCH-ARM / FISHERS |                  P=0.591                  P=0.753N                 P=0.500                  P=0.753N        | 
|ORDER RESTRICTED   |                  P=0.576                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                0/50 (0%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  3/45.65                  0/43.54                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  6.6%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  689                      ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.050N                 P=0.132N                 P=0.144N                 P=0.118N        | 
|POLY 3             |                  P=0.043N*                P=0.127N                 P=0.128N                 P=0.119N        | 
|POLY 1.5           |                  P=0.044N*                P=0.125N                 P=0.124N                 P=0.119N        | 
|POLY 6             |                  P=0.043N*                P=0.131N                 P=0.132N                 P=0.120N        | 
|LOGISTIC REGRESSION|                  P=0.048N*                P=0.128N                 P=0.129N                 P=0.120N        | 
|COCH-ARM / FISHERS |                  P=0.047N*                P=0.121N                 P=0.121N                 P=0.121N        | 
|ORDER RESTRICTED   |                  P=0.008N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  10/49 (20%)              8/48 (17%)               8/48 (17%)               4/49 (8%)       | 
|POLY-3 RATE (b)    |                  10/44.74                 8/43.42                  8/42.27                  4/44.63         | 
|POLY-3 PERCENT (g) |                  22.4%                    18.4%                    18.9%                    9.0%            | 
|TERMINAL (d)       |                  9/36 (25%)               6/36 (17%)               7/33 (21%)               4/39 (10%)      | 
|FIRST INCIDENCE    |                  689                      641                      669                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.049N*                P=0.412N                 P=0.481N                 P=0.055N        | 
|POLY 3             |                  P=0.059N                 P=0.424N                 P=0.449N                 P=0.072N        | 
|POLY 1.5           |                  P=0.059N                 P=0.425N                 P=0.436N                 P=0.072N        | 
|POLY 6             |                  P=0.060N                 P=0.423N                 P=0.464N                 P=0.072N        | 
|LOGISTIC REGRESSION|                  P=0.059N                 P=0.436N                 P=0.478N                 P=0.070N        | 
|COCH-ARM / FISHERS |                  P=0.061N                 P=0.416N                 P=0.416N                 P=0.074N        | 
|ORDER RESTRICTED   |                  P=0.066N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Duodenum: Epithelium                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/48 (2%)                1/48 (2%)                2/46 (4%)                0/46 (0%)       | 
|POLY-3 RATE (b)    |                  1/44.79                  1/42.81                  2/40.87                  0/43.10         | 
|POLY-3 PERCENT (g) |                  2.2%                     2.3%                     4.9%                     0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                1/36 (3%)                1/33 (3%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  707                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.355N                 P=0.762                  P=0.464                  P=0.484N        | 
|POLY 3             |                  P=0.375N                 P=0.750                  P=0.468                  P=0.508N        | 
|POLY 1.5           |                  P=0.377N                 P=0.753                  P=0.474                  P=0.508N        | 
|POLY 6             |                  P=0.371N                 P=0.748                  P=0.464                  P=0.506N        | 
|LOGISTIC REGRESSION|                  P=0.373N                 P=0.762                  P=0.462                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.380N                 P=0.753N                 P=0.484                  P=0.511N        | 
|ORDER RESTRICTED   |                  P=0.261N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Ileum: Epithelium                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/45 (0%)                1/46 (2%)                2/49 (4%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  0/42.02                  1/42.10                  2/43.04                  0/45.10         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.4%                     4.7%                     0.0%            | 
|TERMINAL (d)       |                  0/35 (0%)                1/36 (3%)                1/33 (3%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  604                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.599N                 P=0.506                  P=0.228                  (e)             | 
|POLY 3             |                  P=0.599N                 P=0.500                  P=0.242                  (e)             | 
|POLY 1.5           |                  P=0.597N                 P=0.502                  P=0.247                  (e)             | 
|POLY 6             |                  P=0.600N                 P=0.499                  P=0.237                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.592N                 P=0.506                  P=0.278                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.594N                 P=0.505                  P=0.269                  (e)             | 
|ORDER RESTRICTED   |                  P=0.315N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/49 (2%)                4/48 (8%)                3/48 (6%)                1/49 (2%)       | 
|POLY-3 RATE (b)    |                  1/44.91                  4/42.54                  3/41.70                  1/45.10         | 
|POLY-3 PERCENT (g) |                  2.2%                     9.4%                     7.2%                     2.2%            | 
|TERMINAL (d)       |                  1/36 (3%)                4/36 (11%)               3/33 (9%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.399N                 P=0.179                  P=0.274                  P=0.744N        | 
|POLY 3             |                  P=0.428N                 P=0.162                  P=0.279                  P=0.760N        | 
|POLY 1.5           |                  P=0.427N                 P=0.165                  P=0.287                  P=0.760N        | 
|POLY 6             |                  P=0.429N                 P=0.159                  P=0.270                  P=0.760N        | 
|LOGISTIC REGRESSION|                  P=0.399N                 P=0.179                  P=0.274                  P=0.744N        | 
|COCH-ARM / FISHERS |                  P=0.429N                 P=0.175                  P=0.301                  P=0.753N        | 
|ORDER RESTRICTED   |                  P=0.305N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/50 (16%)               5/49 (10%)               5/50 (10%)               3/50 (6%)       | 
|POLY-3 RATE (b)    |                  8/45.77                  5/43.17                  5/43.48                  3/45.46         | 
|POLY-3 PERCENT (g) |                  17.5%                    11.6%                    11.5%                    6.6%            | 
|TERMINAL (d)       |                  7/36 (19%)               5/36 (14%)               5/33 (15%)               3/39 (8%)       | 
|FIRST INCIDENCE    |                  649                      729 (T)                  729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.069N                 P=0.279N                 P=0.329N                 P=0.080N        | 
|POLY 3             |                  P=0.082N                 P=0.314N                 P=0.309N                 P=0.100N        | 
|POLY 1.5           |                  P=0.083N                 P=0.306N                 P=0.295N                 P=0.099N        | 
|POLY 6             |                  P=0.082N                 P=0.324N                 P=0.328N                 P=0.101N        | 
|LOGISTIC REGRESSION|                  P=0.082N                 P=0.320N                 P=0.331N                 P=0.099N        | 
|COCH-ARM / FISHERS |                  P=0.085N                 P=0.290N                 P=0.277N                 P=0.100N        | 
|ORDER RESTRICTED   |                  P=0.077N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                2/49 (4%)                3/50 (6%)                5/50 (10%)      | 
|POLY-3 RATE (b)    |                  2/45.47                  2/43.17                  3/43.48                  5/45.69         | 
|POLY-3 PERCENT (g) |                  4.4%                     4.6%                     6.9%                     10.9%           | 
|TERMINAL (d)       |                  2/36 (6%)                2/36 (6%)                3/33 (9%)                4/39 (10%)      | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  669             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.138                  P=0.695                  P=0.460                  P=0.246         | 
|POLY 3             |                  P=0.119                  P=0.675                  P=0.480                  P=0.218         | 
|POLY 1.5           |                  P=0.119                  P=0.678                  P=0.488                  P=0.218         | 
|POLY 6             |                  P=0.120                  P=0.671                  P=0.469                  P=0.219         | 
|LOGISTIC REGRESSION|                  P=0.120                  P=0.695                  P=0.460                  P=0.215         | 
|COCH-ARM / FISHERS |                  P=0.116                  P=0.684                  P=0.500                  P=0.218         | 
|ORDER RESTRICTED   |                  P=0.161                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/49 (0%)                0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/45.47                  0/43.17                  0/43.48                  1/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     0.0%                     2.2%            | 
|TERMINAL (d)       |                  2/36 (6%)                0/36 (0%)                0/33 (0%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.443N                 P=0.238N                 P=0.258N                 P=0.472N        | 
|POLY 3             |                  P=0.457N                 P=0.249N                 P=0.247N                 P=0.500N        | 
|POLY 1.5           |                  P=0.457N                 P=0.247N                 P=0.243N                 P=0.500N        | 
|POLY 6             |                  P=0.457N                 P=0.251N                 P=0.252N                 P=0.500N        | 
|LOGISTIC REGRESSION|                  P=0.443N                 (e)                      (e)                      P=0.472N        | 
|COCH-ARM / FISHERS |                  P=0.459N                 P=0.253N                 P=0.247N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.134N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  16/50 (32%)              14/49 (29%)              7/50 (14%)               8/50 (16%)      | 
|POLY-3 RATE (b)    |                  16/46.32                 14/44.20                 7/44.01                  8/45.63         | 
|POLY-3 PERCENT (g) |                  34.6%                    31.7%                    15.9%                    17.5%           | 
|TERMINAL (d)       |                  11/36 (31%)              11/36 (31%)              5/33 (15%)               7/39 (18%)      | 
|FIRST INCIDENCE    |                  649                      547                      658                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.019N*                P=0.449N                 P=0.057N                 P=0.043N*       | 
|POLY 3             |                  P=0.019N*                P=0.473N                 P=0.034N*                P=0.050N        | 
|POLY 1.5           |                  P=0.019N*                P=0.464N                 P=0.031N*                P=0.049N*       | 
|POLY 6             |                  P=0.020N*                P=0.489N                 P=0.040N*                P=0.053N        | 
|LOGISTIC REGRESSION|                  P=0.019N*                P=0.475N                 P=0.036N*                P=0.049N*       | 
|COCH-ARM / FISHERS |                  P=0.020N*                P=0.440N                 P=0.028N*                P=0.050N        | 
|ORDER RESTRICTED   |                  P=0.029N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                6/49 (12%)               4/50 (8%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/45.49                  6/44.72                  4/43.77                  1/45.69         | 
|POLY-3 PERCENT (g) |                  4.4%                     13.4%                    9.1%                     2.2%            | 
|TERMINAL (d)       |                  1/36 (3%)                1/36 (3%)                2/33 (6%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  724                      581                      669                      669             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.231N                 P=0.131                  P=0.292                  P=0.485N        | 
|POLY 3             |                  P=0.228N                 P=0.127                  P=0.319                  P=0.499N        | 
|POLY 1.5           |                  P=0.229N                 P=0.125                  P=0.326                  P=0.499N        | 
|POLY 6             |                  P=0.228N                 P=0.131                  P=0.311                  P=0.498N        | 
|LOGISTIC REGRESSION|                  P=0.232N                 P=0.136                  P=0.311                  P=0.500N        | 
|COCH-ARM / FISHERS |                  P=0.231N                 P=0.128                  P=0.339                  P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.159N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/49 (0%)                2/50 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/46.01                  0/43.17                  2/44.21                  1/45.63         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     4.5%                     2.2%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  606                      ---                      583                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.525N                 P=0.259N                 P=0.663                  P=0.503N        | 
|POLY 3             |                  P=0.522N                 P=0.252N                 P=0.680                  P=0.503N        | 
|POLY 1.5           |                  P=0.523N                 P=0.248N                 P=0.685                  P=0.501N        | 
|POLY 6             |                  P=0.520N                 P=0.256N                 P=0.673                  P=0.505N        | 
|LOGISTIC REGRESSION|                  P=0.543N                 P=0.224N                 P=0.666N                 P=0.506N        | 
|COCH-ARM / FISHERS |                  P=0.528N                 P=0.253N                 P=0.691N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.418N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/49 (0%)                0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/45.92                  0/43.17                  0/43.48                  1/45.76         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     0.0%                     2.2%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  606                      ---                      ---                      647             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.456N                 P=0.251N                 P=0.260N                 P=0.497N        | 
|POLY 3             |                  P=0.456N                 P=0.251N                 P=0.250N                 P=0.501N        | 
|POLY 1.5           |                  P=0.457N                 P=0.248N                 P=0.244N                 P=0.500N        | 
|POLY 6             |                  P=0.455N                 P=0.255N                 P=0.256N                 P=0.502N        | 
|LOGISTIC REGRESSION|                  P=0.466N                 P=0.229N                 P=0.226N                 P=0.508N        | 
|COCH-ARM / FISHERS |                  P=0.459N                 P=0.253N                 P=0.247N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.135N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                0/50 (0%)                5/50 (10%)               2/50 (4%)       | 
|POLY-3 RATE (b)    |                  3/46.28                  0/43.54                  5/43.73                  2/45.46         | 
|POLY-3 PERCENT (g) |                  6.5%                     0.0%                     11.4%                    4.4%            | 
|TERMINAL (d)       |                  2/36 (6%)                0/36 (0%)                4/33 (12%)               2/39 (5%)       | 
|FIRST INCIDENCE    |                  423                      ---                      663                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.573                  P=0.124N                 P=0.320                  P=0.469N        | 
|POLY 3             |                  P=0.552                  P=0.130N                 P=0.326                  P=0.508N        | 
|POLY 1.5           |                  P=0.551                  P=0.126N                 P=0.337                  P=0.505N        | 
|POLY 6             |                  P=0.555                  P=0.134N                 P=0.313                  P=0.510N        | 
|LOGISTIC REGRESSION|                  P=0.544                  P=0.093N                 P=0.366                  P=0.507N        | 
|COCH-ARM / FISHERS |                  P=0.544                  P=0.121N                 P=0.357                  P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.269                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                2/50 (4%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  2/45.47                  1/43.86                  2/43.73                  3/46.19         | 
|POLY-3 PERCENT (g) |                  4.4%                     2.3%                     4.6%                     6.5%            | 
|TERMINAL (d)       |                  2/36 (6%)                0/36 (0%)                1/33 (3%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  729 (T)                  641                      664                      472             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.339                  P=0.508N                 P=0.661                  P=0.531         | 
|POLY 3             |                  P=0.325                  P=0.513N                 P=0.680                  P=0.507         | 
|POLY 1.5           |                  P=0.322                  P=0.509N                 P=0.685                  P=0.505         | 
|POLY 6             |                  P=0.328                  P=0.516N                 P=0.673                  P=0.509         | 
|LOGISTIC REGRESSION|                  P=0.307                  P=0.506N                 P=0.679                  P=0.496         | 
|COCH-ARM / FISHERS |                  P=0.313                  P=0.500N                 P=0.691N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.369                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.47                  0/43.54                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/36 (6%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.113N                 P=0.238N                 P=0.258N                 P=0.221N        | 
|POLY 3             |                  P=0.111N                 P=0.247N                 P=0.247N                 P=0.237N        | 
|POLY 1.5           |                  P=0.112N                 P=0.244N                 P=0.243N                 P=0.237N        | 
|POLY 6             |                  P=0.111N                 P=0.251N                 P=0.252N                 P=0.237N        | 
|LOGISTIC REGRESSION|                  P=0.113N                 (e)                      (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.115N                 P=0.247N                 P=0.247N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.029N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/50 (14%)               4/50 (8%)                8/50 (16%)               4/50 (8%)       | 
|POLY-3 RATE (b)    |                  7/45.47                  4/44.17                  8/43.84                  4/46.19         | 
|POLY-3 PERCENT (g) |                  15.4%                    9.1%                     18.3%                    8.7%            | 
|TERMINAL (d)       |                  7/36 (19%)               3/36 (8%)                6/33 (18%)               3/39 (8%)       | 
|FIRST INCIDENCE    |                  729 (T)                  521                      664                      472             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.277N                 P=0.261N                 P=0.424                  P=0.220N        | 
|POLY 3             |                  P=0.293N                 P=0.277N                 P=0.469                  P=0.252N        | 
|POLY 1.5           |                  P=0.299N                 P=0.273N                 P=0.481                  P=0.255N        | 
|POLY 6             |                  P=0.287N                 P=0.282N                 P=0.456                  P=0.249N        | 
|LOGISTIC REGRESSION|                  P=0.309N                 P=0.282N                 P=0.428                  P=0.261N        | 
|COCH-ARM / FISHERS |                  P=0.313N                 P=0.262N                 P=0.500                  P=0.262N        | 
|ORDER RESTRICTED   |                  P=0.261N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  4/50 (8%)                2/50 (4%)                1/50 (2%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  4/45.70                  2/43.54                  1/43.48                  1/45.46         | 
|POLY-3 PERCENT (g) |                  8.8%                     4.6%                     2.3%                     2.2%            | 
|TERMINAL (d)       |                  3/36 (8%)                2/36 (6%)                1/33 (3%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  669                      729 (T)                  729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.103N                 P=0.345N                 P=0.211N                 P=0.163N        | 
|POLY 3             |                  P=0.110N                 P=0.360N                 P=0.194N                 P=0.180N        | 
|POLY 1.5           |                  P=0.110N                 P=0.352N                 P=0.188N                 P=0.179N        | 
|POLY 6             |                  P=0.109N                 P=0.369N                 P=0.203N                 P=0.181N        | 
|LOGISTIC REGRESSION|                  P=0.111N                 P=0.363N                 P=0.197N                 P=0.179N        | 
|COCH-ARM / FISHERS |                  P=0.111N                 P=0.339N                 P=0.181N                 P=0.181N        | 
|ORDER RESTRICTED   |                  P=0.096N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                5/50 (10%)               6/50 (12%)               1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/45.47                  5/43.54                  6/43.48                  1/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     11.5%                    13.8%                    2.2%            | 
|TERMINAL (d)       |                  2/36 (6%)                5/36 (14%)               6/33 (18%)               1/39 (3%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.284N                 P=0.215                  P=0.105                  P=0.472N        | 
|POLY 3             |                  P=0.314N                 P=0.198                  P=0.118                  P=0.500N        | 
|POLY 1.5           |                  P=0.315N                 P=0.204                  P=0.124                  P=0.500N        | 
|POLY 6             |                  P=0.313N                 P=0.192                  P=0.111                  P=0.500N        | 
|LOGISTIC REGRESSION|                  P=0.284N                 P=0.215                  P=0.105                  P=0.472N        | 
|COCH-ARM / FISHERS |                  P=0.320N                 P=0.218                  P=0.134                  P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.131N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                0/50 (0%)                0/50 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  0/43.54                  0/43.48                  2/45.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     4.4%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.055                  (e)                      (e)                      P=0.256         | 
|POLY 3             |                  P=0.046 *                (e)                      (e)                      P=0.237         | 
|POLY 1.5           |                  P=0.046 *                (e)                      (e)                      P=0.237         | 
|POLY 6             |                  P=0.046 *                (e)                      (e)                      P=0.237         | 
|LOGISTIC REGRESSION|                  (e)                      (e)                      (e)                      P=0.256         | 
|COCH-ARM / FISHERS |                  P=0.046 *                (e)                      (e)                      P=0.247         | 
|ORDER RESTRICTED   |                  P=0.029 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/50 (12%)               6/50 (12%)               7/50 (14%)               5/50 (10%)      | 
|POLY-3 RATE (b)    |                  6/45.47                  6/44.75                  7/44.32                  5/45.60         | 
|POLY-3 PERCENT (g) |                  13.2%                    13.4%                    15.8%                    11.0%           | 
|TERMINAL (d)       |                  6/36 (17%)               4/36 (11%)               5/33 (15%)               4/39 (10%)      | 
|FIRST INCIDENCE    |                  729 (T)                  521                      539                      693             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.400N                 P=0.617                  P=0.435                  P=0.449N        | 
|POLY 3             |                  P=0.437N                 P=0.610                  P=0.480                  P=0.498N        | 
|POLY 1.5           |                  P=0.437N                 P=0.611                  P=0.488                  P=0.498N        | 
|POLY 6             |                  P=0.435N                 P=0.608                  P=0.471                  P=0.497N        | 
|LOGISTIC REGRESSION|                  P=0.438N                 P=0.614                  P=0.471                  P=0.498N        | 
|COCH-ARM / FISHERS |                  P=0.442N                 P=0.620N                 P=0.500                  P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.517N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                3/50 (6%)                3/50 (6%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  3/45.53                  3/43.54                  3/44.08                  2/45.46         | 
|POLY-3 PERCENT (g) |                  6.6%                     6.9%                     6.8%                     4.4%            | 
|TERMINAL (d)       |                  2/36 (6%)                3/36 (8%)                2/33 (6%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  715                      729 (T)                  539                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.372N                 P=0.654                  P=0.616                  P=0.473N        | 
|POLY 3             |                  P=0.393N                 P=0.642                  P=0.647                  P=0.501N        | 
|POLY 1.5           |                  P=0.393N                 P=0.648                  P=0.653                  P=0.500N        | 
|POLY 6             |                  P=0.392N                 P=0.634                  P=0.639                  P=0.502N        | 
|LOGISTIC REGRESSION|                  P=0.393N                 P=0.628                  P=0.661                  P=0.498N        | 
|COCH-ARM / FISHERS |                  P=0.397N                 P=0.661N                 P=0.661N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.503N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                5/50 (10%)               2/50 (4%)                4/50 (8%)       | 
|POLY-3 RATE (b)    |                  3/45.50                  5/45.39                  2/43.71                  4/45.81         | 
|POLY-3 PERCENT (g) |                  6.6%                     11.0%                    4.6%                     8.7%            | 
|TERMINAL (d)       |                  2/36 (6%)                1/36 (3%)                1/33 (3%)                3/39 (8%)       | 
|FIRST INCIDENCE    |                  723                      318                      669                      631             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.562                  P=0.342                  P=0.547N                 P=0.534         | 
|POLY 3             |                  P=0.538                  P=0.355                  P=0.518N                 P=0.504         | 
|POLY 1.5           |                  P=0.538                  P=0.355                  P=0.511N                 P=0.503         | 
|POLY 6             |                  P=0.539                  P=0.356                  P=0.527N                 P=0.506         | 
|LOGISTIC REGRESSION|                  P=0.527                  P=0.406                  P=0.526N                 P=0.500         | 
|COCH-ARM / FISHERS |                  P=0.537                  P=0.357                  P=0.500N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.550                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Tension Lipidosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                0/50 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  2/46.01                  0/43.54                  0/43.48                  2/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     0.0%                     4.4%            | 
|TERMINAL (d)       |                  1/36 (3%)                0/36 (0%)                0/33 (0%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  563                      ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.514                  P=0.247N                 P=0.257N                 P=0.676N        | 
|POLY 3             |                  P=0.506                  P=0.250N                 P=0.250N                 P=0.689         | 
|POLY 1.5           |                  P=0.505                  P=0.245N                 P=0.245N                 P=0.692         | 
|POLY 6             |                  P=0.508                  P=0.255N                 P=0.257N                 P=0.687         | 
|LOGISTIC REGRESSION|                  P=0.499                  P=0.214N                 P=0.219N                 P=0.694         | 
|COCH-ARM / FISHERS |                  P=0.500                  P=0.247N                 P=0.247N                 P=0.691N        | 
|ORDER RESTRICTED   |                  P=0.273                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/50 (12%)               1/50 (2%)                2/50 (4%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  6/47.38                  1/43.97                  2/44.16                  3/46.50         | 
|POLY-3 PERCENT (g) |                  12.7%                    2.3%                     4.5%                     6.5%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  563                      604                      604                      522             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.281N                 P=0.078N                 P=0.169N                 P=0.260N        | 
|POLY 3             |                  P=0.263N                 P=0.069N                 P=0.157N                 P=0.252N        | 
|POLY 1.5           |                  P=0.265N                 P=0.064N                 P=0.147N                 P=0.247N        | 
|POLY 6             |                  P=0.261N                 P=0.076N                 P=0.171N                 P=0.259N        | 
|LOGISTIC REGRESSION|                  P=0.294N                 P=0.038N*                P=0.101N                 P=0.246N        | 
|COCH-ARM / FISHERS |                  P=0.273N                 P=0.056N                 P=0.134N                 P=0.243N        | 
|ORDER RESTRICTED   |                  P=0.077N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Depletion Glycogen                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                2/50 (4%)                1/50 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  3/45.47                  2/43.54                  1/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  6.6%                     4.6%                     2.3%                     0.0%            | 
|TERMINAL (d)       |                  3/36 (8%)                2/36 (6%)                1/33 (3%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.057N                 P=0.500N                 P=0.336N                 P=0.107N        | 
|POLY 3             |                  P=0.061N                 P=0.520N                 P=0.321N                 P=0.119N        | 
|POLY 1.5           |                  P=0.061N                 P=0.514N                 P=0.315N                 P=0.119N        | 
|POLY 6             |                  P=0.060N                 P=0.527N                 P=0.330N                 P=0.119N        | 
|LOGISTIC REGRESSION|                  P=0.057N                 P=0.500N                 P=0.336N                 (e)             | 
|COCH-ARM / FISHERS |                  P=0.062N                 P=0.500N                 P=0.309N                 P=0.121N        | 
|ORDER RESTRICTED   |                  P=0.057N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Karyomegaly                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                4/50 (8%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.47                  4/43.54                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     9.2%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/36 (6%)                4/36 (11%)               0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.057N                 P=0.336                  P=0.258N                 P=0.221N        | 
|POLY 3             |                  P=0.061N                 P=0.317                  P=0.247N                 P=0.237N        | 
|POLY 1.5           |                  P=0.061N                 P=0.324                  P=0.243N                 P=0.237N        | 
|POLY 6             |                  P=0.062N                 P=0.309                  P=0.252N                 P=0.237N        | 
|LOGISTIC REGRESSION|                  P=0.057N                 P=0.336                  (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.062N                 P=0.339                  P=0.247N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.049N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/50 (12%)               3/50 (6%)                6/50 (12%)               3/50 (6%)       | 
|POLY-3 RATE (b)    |                  6/46.43                  3/44.49                  6/45.85                  3/45.69         | 
|POLY-3 PERCENT (g) |                  12.9%                    6.7%                     13.1%                    6.6%            | 
|TERMINAL (d)       |                  2/36 (6%)                1/36 (3%)                1/33 (3%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  581                      521                      455                      669             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.274N                 P=0.276N                 P=0.567                  P=0.239N        | 
|POLY 3             |                  P=0.278N                 P=0.263N                 P=0.612                  P=0.250N        | 
|POLY 1.5           |                  P=0.277N                 P=0.257N                 P=0.616                  P=0.246N        | 
|POLY 6             |                  P=0.280N                 P=0.273N                 P=0.603                  P=0.255N        | 
|LOGISTIC REGRESSION|                  P=0.296N                 P=0.216N                 P=0.560N                 P=0.243N        | 
|COCH-ARM / FISHERS |                  P=0.279N                 P=0.243N                 P=0.620N                 P=0.243N        | 
|ORDER RESTRICTED   |                  P=0.242N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Kupffer Cell                                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.97                  1/43.69                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     2.3%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  581                      689                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.104N                 P=0.517N                 P=0.254N                 P=0.233N        | 
|POLY 3             |                  P=0.101N                 P=0.518N                 P=0.250N                 P=0.240N        | 
|POLY 1.5           |                  P=0.100N                 P=0.512N                 P=0.245N                 P=0.238N        | 
|POLY 6             |                  P=0.101N                 P=0.524N                 P=0.256N                 P=0.241N        | 
|LOGISTIC REGRESSION|                  P=0.100N                 P=0.482N                 P=0.222N                 P=0.242N        | 
|COCH-ARM / FISHERS |                  P=0.101N                 P=0.500N                 P=0.247N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.076N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Kupffer Cell                                                                                                              | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  7/50 (14%)               0/50 (0%)                2/50 (4%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  7/45.91                  0/43.54                  2/43.73                  1/45.46         | 
|POLY-3 PERCENT (g) |                  15.3%                    0.0%                     4.6%                     2.2%            | 
|TERMINAL (d)       |                  4/36 (11%)               0/36 (0%)                1/33 (3%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  669                      ---                      664                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.032N*                P=0.013N*                P=0.117N                 P=0.031N*       | 
|POLY 3             |                  P=0.026N*                P=0.009N**               P=0.091N                 P=0.031N*       | 
|POLY 1.5           |                  P=0.026N*                P=0.009N**               P=0.086N                 P=0.031N*       | 
|POLY 6             |                  P=0.025N*                P=0.010N*                P=0.097N                 P=0.032N*       | 
|LOGISTIC REGRESSION|                  P=0.031N*                P=0.011N*                P=0.089N                 P=0.032N*       | 
|COCH-ARM / FISHERS |                  P=0.031N*                P=0.006N**               P=0.080N                 P=0.030N*       | 
|ORDER RESTRICTED   |                  P=0.003N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                0/50 (0%)                0/50 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  1/45.91                  0/43.54                  0/43.48                  2/45.46         | 
|POLY-3 PERCENT (g) |                  2.2%                     0.0%                     0.0%                     4.4%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  604                      ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.260                  P=0.509N                 P=0.509N                 P=0.516         | 
|POLY 3             |                  P=0.249                  P=0.511N                 P=0.511N                 P=0.497         | 
|POLY 1.5           |                  P=0.248                  P=0.507N                 P=0.506N                 P=0.499         | 
|POLY 6             |                  P=0.250                  P=0.515N                 P=0.517N                 P=0.494         | 
|LOGISTIC REGRESSION|                  P=0.244                  P=0.461N                 P=0.473N                 P=0.499         | 
|COCH-ARM / FISHERS |                  P=0.246                  P=0.500N                 P=0.500N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.131                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/50 (12%)               7/50 (14%)               6/50 (12%)               7/50 (14%)      | 
|POLY-3 RATE (b)    |                  6/46.03                  7/44.18                  6/44.12                  7/45.94         | 
|POLY-3 PERCENT (g) |                  13.0%                    15.8%                    13.6%                    15.2%           | 
|TERMINAL (d)       |                  3/36 (8%)                5/36 (14%)               3/33 (9%)                6/39 (15%)      | 
|FIRST INCIDENCE    |                  604                      640                      659                      587             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.515                  P=0.482                  P=0.555                  P=0.542         | 
|POLY 3             |                  P=0.476                  P=0.468                  P=0.591                  P=0.498         | 
|POLY 1.5           |                  P=0.477                  P=0.478                  P=0.602                  P=0.500         | 
|POLY 6             |                  P=0.475                  P=0.458                  P=0.577                  P=0.496         | 
|LOGISTIC REGRESSION|                  P=0.477                  P=0.482                  P=0.608                  P=0.500         | 
|COCH-ARM / FISHERS |                  P=0.472                  P=0.500                  P=0.620N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.595                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                0/50 (0%)                4/50 (8%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  1/45.47                  0/43.54                  4/43.73                  1/46.07         | 
|POLY-3 PERCENT (g) |                  2.2%                     0.0%                     9.2%                     2.2%            | 
|TERMINAL (d)       |                  1/36 (3%)                0/36 (0%)                3/33 (9%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  ---                      663                      535             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.465                  P=0.500N                 P=0.158                  P=0.754N        | 
|POLY 3             |                  P=0.465                  P=0.509N                 P=0.167                  P=0.758N        | 
|POLY 1.5           |                  P=0.458                  P=0.506N                 P=0.172                  P=0.758N        | 
|POLY 6             |                  P=0.472                  P=0.512N                 P=0.161                  P=0.757N        | 
|LOGISTIC REGRESSION|                  P=0.442                  (e)                      P=0.162                  P=0.753         | 
|COCH-ARM / FISHERS |                  P=0.444                  P=0.500N                 P=0.181                  P=0.753N        | 
|ORDER RESTRICTED   |                  P=0.177                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/50 (2%)                5/50 (10%)               0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.53                  1/43.54                  5/43.67                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     2.3%                     11.5%                    0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                1/36 (3%)                3/33 (9%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  715                      729 (T)                  696                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.302N                 P=0.512N                 P=0.178                  P=0.234N        | 
|POLY 3             |                  P=0.302N                 P=0.516N                 P=0.199                  P=0.237N        | 
|POLY 1.5           |                  P=0.304N                 P=0.511N                 P=0.206                  P=0.237N        | 
|POLY 6             |                  P=0.299N                 P=0.522N                 P=0.191                  P=0.238N        | 
|LOGISTIC REGRESSION|                  P=0.310N                 P=0.525N                 P=0.187                  P=0.237N        | 
|COCH-ARM / FISHERS |                  P=0.313N                 P=0.500N                 P=0.218                  P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.119N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)                1/50 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  1/46.01                  2/44.07                  1/43.91                  0/45.46         | 
|POLY-3 PERCENT (g) |                  2.2%                     4.5%                     2.3%                     0.0%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  563                      641                      604                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.252N                 P=0.476                  P=0.748                  P=0.508N        | 
|POLY 3             |                  P=0.252N                 P=0.485                  P=0.750                  P=0.502N        | 
|POLY 1.5           |                  P=0.250N                 P=0.489                  P=0.754                  P=0.501N        | 
|POLY 6             |                  P=0.255N                 P=0.481                  P=0.745                  P=0.504N        | 
|LOGISTIC REGRESSION|                  P=0.259N                 P=0.549                  P=0.732N                 P=0.539N        | 
|COCH-ARM / FISHERS |                  P=0.247N                 P=0.500                  P=0.753N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.218N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                1/50 (2%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  2/43.54                  1/43.48                  2/45.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.6%                     2.3%                     4.4%            | 
|TERMINAL (d)       |                  0/36 (0%)                2/36 (6%)                1/33 (3%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.270                  P=0.238                  P=0.483                  P=0.256         | 
|POLY 3             |                  P=0.246                  P=0.227                  P=0.491                  P=0.237         | 
|POLY 1.5           |                  P=0.246                  P=0.231                  P=0.495                  P=0.237         | 
|POLY 6             |                  P=0.245                  P=0.224                  P=0.486                  P=0.237         | 
|LOGISTIC REGRESSION|                  (e)                      P=0.238                  P=0.483                  P=0.256         | 
|COCH-ARM / FISHERS |                  P=0.245                  P=0.247                  P=0.500                  P=0.247         | 
|ORDER RESTRICTED   |                  P=0.155                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia Bronchiolar                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/50 (4%)                0/50 (0%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  2/44.03                  0/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.5%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/36 (0%)                1/36 (3%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  ---                      581                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.401N                 P=0.235                  (e)                      (e)             | 
|POLY 3             |                  P=0.412N                 P=0.230                  (e)                      (e)             | 
|POLY 1.5           |                  P=0.409N                 P=0.232                  (e)                      (e)             | 
|POLY 6             |                  P=0.415N                 P=0.228                  (e)                      (e)             | 
|LOGISTIC REGRESSION|                  P=0.411N                 P=0.251                  (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.405N                 P=0.247                  (e)                      (e)             | 
|ORDER RESTRICTED   |                  P=0.241N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                1/50 (2%)                1/47 (2%)       | 
|POLY-3 RATE (b)    |                  2/46.86                  0/43.54                  1/43.73                  1/43.91         | 
|POLY-3 PERCENT (g) |                  4.3%                     0.0%                     2.3%                     2.3%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                0/38 (0%)       | 
|FIRST INCIDENCE    |                  350                      ---                      664                      424             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.495N                 P=0.249N                 P=0.519N                 P=0.498N        | 
|POLY 3             |                  P=0.509N                 P=0.254N                 P=0.524N                 P=0.523N        | 
|POLY 1.5           |                  P=0.512N                 P=0.249N                 P=0.515N                 P=0.522N        | 
|POLY 6             |                  P=0.505N                 P=0.260N                 P=0.534N                 P=0.522N        | 
|LOGISTIC REGRESSION|                  P=0.621N                 P=0.106N                 P=0.420N                 P=0.642N        | 
|COCH-ARM / FISHERS |                  P=0.519N                 P=0.247N                 P=0.500N                 P=0.523N        | 
|ORDER RESTRICTED   |                  P=0.297N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/50 (4%)                0/50 (0%)                1/47 (2%)       | 
|POLY-3 RATE (b)    |                  1/46.01                  2/43.54                  0/43.48                  1/43.11         | 
|POLY-3 PERCENT (g) |                  2.2%                     4.6%                     0.0%                     2.3%            | 
|TERMINAL (d)       |                  0/36 (0%)                2/36 (6%)                0/33 (0%)                1/38 (3%)       | 
|FIRST INCIDENCE    |                  563                      729 (T)                  ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.492N                 P=0.493                  P=0.513N                 P=0.759N        | 
|POLY 3             |                  P=0.525N                 P=0.481                  P=0.511N                 P=0.746         | 
|POLY 1.5           |                  P=0.522N                 P=0.487                  P=0.507N                 P=0.746         | 
|POLY 6             |                  P=0.527N                 P=0.473                  P=0.517N                 P=0.746         | 
|LOGISTIC REGRESSION|                  P=0.520N                 P=0.512                  P=0.464N                 P=0.740         | 
|COCH-ARM / FISHERS |                  P=0.519N                 P=0.500                  P=0.500N                 P=0.737         | 
|ORDER RESTRICTED   |                  P=0.387N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                3/50 (6%)                2/50 (4%)                3/47 (6%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  3/44.11                  2/43.61                  3/43.74         | 
|POLY-3 PERCENT (g) |                  0.0%                     6.8%                     4.6%                     6.9%            | 
|TERMINAL (d)       |                  0/36 (0%)                2/36 (6%)                1/33 (3%)                2/38 (5%)       | 
|FIRST INCIDENCE    |                  ---                      547                      696                      522             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.178                  P=0.120                  P=0.219                  P=0.129         | 
|POLY 3             |                  P=0.153                  P=0.113                  P=0.228                  P=0.112         | 
|POLY 1.5           |                  P=0.150                  P=0.115                  P=0.232                  P=0.110         | 
|POLY 6             |                  P=0.156                  P=0.111                  P=0.223                  P=0.114         | 
|LOGISTIC REGRESSION|                  P=0.140                  P=0.127                  P=0.227                  P=0.103         | 
|COCH-ARM / FISHERS |                  P=0.146                  P=0.121                  P=0.247                  P=0.110         | 
|ORDER RESTRICTED   |                  P=0.089                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/50 (16%)               9/50 (18%)               6/50 (12%)               9/47 (19%)      | 
|POLY-3 RATE (b)    |                  8/45.90                  9/44.91                  6/43.91                  9/43.44         | 
|POLY-3 PERCENT (g) |                  17.4%                    20.0%                    13.7%                    20.7%           | 
|TERMINAL (d)       |                  7/36 (19%)               6/36 (17%)               5/33 (15%)               7/38 (18%)      | 
|FIRST INCIDENCE    |                  606                      521                      604                      669             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.533                  P=0.490                  P=0.450N                 P=0.540         | 
|POLY 3             |                  P=0.448                  P=0.480                  P=0.421N                 P=0.450         | 
|POLY 1.5           |                  P=0.447                  P=0.485                  P=0.407N                 P=0.448         | 
|POLY 6             |                  P=0.452                  P=0.474                  P=0.438N                 P=0.456         | 
|LOGISTIC REGRESSION|                  P=0.452                  P=0.491                  P=0.419N                 P=0.452         | 
|COCH-ARM / FISHERS |                  P=0.442                  P=0.500                  P=0.387N                 P=0.444         | 
|ORDER RESTRICTED   |                  P=0.515                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  22/50 (44%)              27/50 (54%)              25/50 (50%)              20/47 (43%)     | 
|POLY-3 RATE (b)    |                  22/47.62                 27/44.63                 25/44.21                 20/43.46        | 
|POLY-3 PERCENT (g) |                  46.2%                    60.5%                    56.6%                    46.0%           | 
|TERMINAL (d)       |                  17/36 (47%)              23/36 (64%)              21/33 (64%)              19/38 (50%)     | 
|FIRST INCIDENCE    |                  350                      604                      658                      631             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.207N                 P=0.203                  P=0.218                  P=0.347N        | 
|POLY 3             |                  P=0.414N                 P=0.118                  P=0.214                  P=0.577N        | 
|POLY 1.5           |                  P=0.396N                 P=0.144                  P=0.260                  P=0.557N        | 
|POLY 6             |                  P=0.431N                 P=0.096                  P=0.169                  P=0.575         | 
|LOGISTIC REGRESSION|                  P=0.338N                 P=0.165                  P=0.281                  P=0.517N        | 
|COCH-ARM / FISHERS |                  P=0.375N                 P=0.212                  P=0.344                  P=0.525N        | 
|ORDER RESTRICTED   |                  P=0.334                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/49 (2%)                0/48 (0%)                0/46 (0%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  1/45.36                  0/42.17                  0/40.29                  2/46.99         | 
|POLY-3 PERCENT (g) |                  2.2%                     0.0%                     0.0%                     4.3%            | 
|TERMINAL (d)       |                  0/35 (0%)                0/35 (0%)                0/32 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  350                      ---                      ---                      424             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.254                  P=0.508N                 P=0.504N                 P=0.507         | 
|POLY 3             |                  P=0.260                  P=0.515N                 P=0.524N                 P=0.512         | 
|POLY 1.5           |                  P=0.258                  P=0.512N                 P=0.520N                 P=0.510         | 
|POLY 6             |                  P=0.263                  P=0.517N                 P=0.527N                 P=0.515         | 
|LOGISTIC REGRESSION|                  P=0.089                  P=0.274N                 P=0.407N                 P=0.275         | 
|COCH-ARM / FISHERS |                  P=0.253                  P=0.505N                 P=0.516N                 P=0.508         | 
|ORDER RESTRICTED   |                  P=0.145                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/49 (0%)                0/48 (0%)                2/46 (4%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/44.47                  0/42.17                  2/40.51                  2/45.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     4.9%                     4.4%            | 
|TERMINAL (d)       |                  0/35 (0%)                0/35 (0%)                1/32 (3%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      669                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.103                  (e)                      P=0.217                  P=0.262         | 
|POLY 3             |                  P=0.093                  (e)                      P=0.216                  P=0.242         | 
|POLY 1.5           |                  P=0.093                  (e)                      P=0.219                  P=0.242         | 
|POLY 6             |                  P=0.094                  (e)                      P=0.215                  P=0.242         | 
|LOGISTIC REGRESSION|                  P=0.094                  (e)                      P=0.221                  P=0.262         | 
|COCH-ARM / FISHERS |                  P=0.091                  (e)                      P=0.232                  P=0.253         | 
|ORDER RESTRICTED   |                  P=0.101                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/49 (6%)                2/48 (4%)                3/46 (7%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  3/44.47                  2/42.17                  3/40.35                  0/45.46         | 
|POLY-3 PERCENT (g) |                  6.8%                     4.7%                     7.4%                     0.0%            | 
|TERMINAL (d)       |                  3/35 (9%)                2/35 (6%)                2/32 (6%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  714                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.100N                 P=0.500N                 P=0.615                  P=0.102N        | 
|POLY 3             |                  P=0.107N                 P=0.524N                 P=0.617                  P=0.115N        | 
|POLY 1.5           |                  P=0.107N                 P=0.520N                 P=0.623                  P=0.115N        | 
|POLY 6             |                  P=0.105N                 P=0.529N                 P=0.612                  P=0.114N        | 
|LOGISTIC REGRESSION|                  P=0.107N                 P=0.500N                 P=0.603                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.110N                 P=0.510N                 P=0.631                  P=0.117N        | 
|ORDER RESTRICTED   |                  P=0.091N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/49 (12%)               9/48 (19%)               4/46 (9%)                7/50 (14%)      | 
|POLY-3 RATE (b)    |                  6/44.47                  9/43.18                  4/40.88                  7/45.46         | 
|POLY-3 PERCENT (g) |                  13.5%                    20.8%                    9.8%                     15.4%           | 
|TERMINAL (d)       |                  6/35 (17%)               7/35 (20%)               3/32 (9%)                7/39 (18%)      | 
|FIRST INCIDENCE    |                  729 (T)                  547                      539                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.456N                 P=0.283                  P=0.423N                 P=0.585         | 
|POLY 3             |                  P=0.511N                 P=0.265                  P=0.423N                 P=0.517         | 
|POLY 1.5           |                  P=0.509N                 P=0.265                  P=0.419N                 P=0.517         | 
|POLY 6             |                  P=0.512N                 P=0.265                  P=0.427N                 P=0.517         | 
|LOGISTIC REGRESSION|                  P=0.504N                 P=0.255                  P=0.428N                 P=0.585         | 
|COCH-ARM / FISHERS |                  P=0.511N                 P=0.273                  P=0.411N                 P=0.516         | 
|ORDER RESTRICTED   |                  P=0.439N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Iliac                                                                                                                | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/16 (19%)               0/9 (0%)                 0/7 (0%)                 0/4 (0%)        | 
|POLY-3 RATE (b)    |                  3/14.27                  0/6.81                   0/6.09                   0/3.25          | 
|POLY-3 PERCENT (g) |                  21.0%                    0.0%                     0.0%                     0.0%            | 
|TERMINAL (d)       |                  2/7 (29%)                0/2 (0%)                 0/2 (0%)                 0/2 (0%)        | 
|FIRST INCIDENCE    |                  423                      ---                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.119N                 P=0.282N                 P=0.282N                 P=0.280N        | 
|POLY 3             |                  P=0.136N                 P=0.272N                 P=0.295N                 P=0.465N        | 
|POLY 1.5           |                  P=0.138N                 P=0.250N                 P=0.292N                 P=0.455N        | 
|POLY 6             |                  P=0.138N                 P=0.313N                 P=0.306N                 P=0.474N        | 
|LOGISTIC REGRESSION|                  P=0.152N                 P=0.214N                 P=0.357N                 P=0.421N        | 
|COCH-ARM / FISHERS |                  P=0.144N                 P=0.243N                 P=0.316N                 P=0.491N        | 
|ORDER RESTRICTED   |                  P=0.324N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  9/50 (18%)               4/50 (8%)                4/50 (8%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  9/46.11                  4/43.54                  4/44.23                  2/45.63         | 
|POLY-3 PERCENT (g) |                  19.5%                    9.2%                     9.0%                     4.4%            | 
|TERMINAL (d)       |                  6/36 (17%)               4/36 (11%)               1/33 (3%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  606                      729 (T)                  659                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.023N*                P=0.129N                 P=0.165N                 P=0.026N*       | 
|POLY 3             |                  P=0.020N*                P=0.138N                 P=0.131N                 P=0.026N*       | 
|POLY 1.5           |                  P=0.021N*                P=0.130N                 P=0.125N                 P=0.026N*       | 
|POLY 6             |                  P=0.020N*                P=0.149N                 P=0.138N                 P=0.026N*       | 
|LOGISTIC REGRESSION|                  P=0.023N*                P=0.135N                 P=0.122N                 P=0.027N*       | 
|COCH-ARM / FISHERS |                  P=0.023N*                P=0.117N                 P=0.117N                 P=0.026N*       | 
|ORDER RESTRICTED   |                  P=0.011N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/21 (0%)                2/17 (12%)               0/16 (0%)                0/17 (0%)       | 
|POLY-3 RATE (b)    |                  0/17.79                  2/15.25                  0/14.49                  0/15.79         | 
|POLY-3 PERCENT (g) |                  0.0%                     13.1%                    0.0%                     0.0%            | 
|TERMINAL (d)       |                  0/11 (0%)                1/11 (9%)                0/8 (0%)                 0/14 (0%)       | 
|FIRST INCIDENCE    |                  ---                      217                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.384N                 P=0.238                  (e)                      (e)             | 
|POLY 3             |                  P=0.413N                 P=0.196                  (e)                      (e)             | 
|POLY 1.5           |                  P=0.424N                 P=0.193                  (e)                      (e)             | 
|POLY 6             |                  P=0.401N                 P=0.199                  (e)                      (e)             | 
|LOGISTIC REGRESSION|                  P=0.650N                 P=0.236                  (e)                      (e)             | 
|COCH-ARM / FISHERS |                  P=0.444N                 P=0.193                  (e)                      (e)             | 
|ORDER RESTRICTED   |                  P=0.235N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  12/21 (57%)              8/17 (47%)               11/16 (69%)              13/17 (76%)     | 
|POLY-3 RATE (b)    |                  12/20.12                 8/14.48                  11/15.04                 13/16.26        | 
|POLY-3 PERCENT (g) |                  59.7%                    55.2%                    73.1%                    79.9%           | 
|TERMINAL (d)       |                  6/11 (55%)               7/11 (64%)               8/8 (100%)               12/14 (86%)     | 
|FIRST INCIDENCE    |                  350                      674                      658                      587             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.529                  P=0.219N                 P=0.428                  P=0.488N        | 
|POLY 3             |                  P=0.082                  P=0.535N                 P=0.315                  P=0.164         | 
|POLY 1.5           |                  P=0.084                  P=0.489N                 P=0.336                  P=0.169         | 
|POLY 6             |                  P=0.082                  P=0.588N                 P=0.272                  P=0.167         | 
|LOGISTIC REGRESSION|                  P=0.124                  P=0.395N                 P=0.336                  P=0.177         | 
|COCH-ARM / FISHERS |                  P=0.083                  P=0.385N                 P=0.354                  P=0.183         | 
|ORDER RESTRICTED   |                  P=0.098                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  5/50 (10%)               6/49 (12%)               5/50 (10%)               9/49 (18%)      | 
|POLY-3 RATE (b)    |                  5/45.50                  6/42.99                  5/43.73                  9/44.87         | 
|POLY-3 PERCENT (g) |                  11.0%                    14.0%                    11.4%                    20.1%           | 
|TERMINAL (d)       |                  4/36 (11%)               4/35 (11%)               4/33 (12%)               7/38 (18%)      | 
|FIRST INCIDENCE    |                  723                      640                      663                      647             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.179                  P=0.473                  P=0.573                  P=0.223         | 
|POLY 3             |                  P=0.144                  P=0.460                  P=0.605                  P=0.184         | 
|POLY 1.5           |                  P=0.144                  P=0.467                  P=0.615                  P=0.184         | 
|POLY 6             |                  P=0.146                  P=0.453                  P=0.594                  P=0.185         | 
|LOGISTIC REGRESSION|                  P=0.145                  P=0.445                  P=0.580                  P=0.178         | 
|COCH-ARM / FISHERS |                  P=0.141                  P=0.486                  P=0.630N                 P=0.183         | 
|ORDER RESTRICTED   |                  P=0.164                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  8/50 (16%)               13/49 (27%)              11/50 (22%)              14/49 (29%)     | 
|POLY-3 RATE (b)    |                  8/46.51                  13/43.24                 11/44.08                 14/45.48        | 
|POLY-3 PERCENT (g) |                  17.2%                    30.1%                    25.0%                    30.8%           | 
|TERMINAL (d)       |                  6/36 (17%)               11/35 (31%)              10/33 (30%)              10/38 (26%)     | 
|FIRST INCIDENCE    |                  563                      547                      539                      631             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.180                  P=0.146                  P=0.240                  P=0.144         | 
|POLY 3             |                  P=0.129                  P=0.116                  P=0.259                  P=0.098         | 
|POLY 1.5           |                  P=0.130                  P=0.127                  P=0.278                  P=0.100         | 
|POLY 6             |                  P=0.131                  P=0.104                  P=0.235                  P=0.099         | 
|LOGISTIC REGRESSION|                  P=0.135                  P=0.134                  P=0.287                  P=0.103         | 
|COCH-ARM / FISHERS |                  P=0.131                  P=0.150                  P=0.306                  P=0.103         | 
|ORDER RESTRICTED   |                  P=0.098                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary: Corpus Luteum                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                1/49 (2%)                3/50 (6%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  3/45.47                  1/43.17                  3/43.91                  0/44.46         | 
|POLY-3 PERCENT (g) |                  6.6%                     2.3%                     6.8%                     0.0%            | 
|TERMINAL (d)       |                  3/36 (8%)                0/35 (0%)                2/33 (6%)                0/38 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  521                      604                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.132N                 P=0.314N                 P=0.625                  P=0.111N        | 
|POLY 3             |                  P=0.134N                 P=0.324N                 P=0.646                  P=0.123N        | 
|POLY 1.5           |                  P=0.134N                 P=0.321N                 P=0.652                  P=0.122N        | 
|POLY 6             |                  P=0.133N                 P=0.328N                 P=0.639                  P=0.123N        | 
|LOGISTIC REGRESSION|                  P=0.137N                 P=0.301N                 P=0.648                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.137N                 P=0.316N                 P=0.661N                 P=0.125N        | 
|ORDER RESTRICTED   |                  P=0.079N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary: Granulosa Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                0/49 (0%)                0/50 (0%)                2/49 (4%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  0/42.54                  0/43.48                  2/44.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     0.0%                     4.5%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/35 (0%)                0/33 (0%)                2/38 (5%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.053                  (e)                      (e)                      P=0.250         | 
|POLY 3             |                  P=0.045 *                (e)                      (e)                      P=0.232         | 
|POLY 1.5           |                  P=0.045 *                (e)                      (e)                      P=0.233         | 
|POLY 6             |                  P=0.045 *                (e)                      (e)                      P=0.232         | 
|LOGISTIC REGRESSION|                  (e)                      (e)                      (e)                      P=0.250         | 
|COCH-ARM / FISHERS |                  P=0.045 *                (e)                      (e)                      P=0.242         | 
|ORDER RESTRICTED   |                  P=0.028 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/50 (2%)                2/48 (4%)                2/49 (4%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  1/45.47                  2/42.54                  2/43.37                  0/45.10         | 
|POLY-3 PERCENT (g) |                  2.2%                     4.7%                     4.6%                     0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                2/36 (6%)                1/33 (3%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  455                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.282N                 P=0.500                  P=0.482                  P=0.484N        | 
|POLY 3             |                  P=0.295N                 P=0.477                  P=0.483                  P=0.502N        | 
|POLY 1.5           |                  P=0.296N                 P=0.479                  P=0.487                  P=0.502N        | 
|POLY 6             |                  P=0.293N                 P=0.475                  P=0.478                  P=0.501N        | 
|LOGISTIC REGRESSION|                  P=0.304N                 P=0.500                  P=0.525                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.299N                 P=0.485                  P=0.492                  P=0.505N        | 
|ORDER RESTRICTED   |                  P=0.212N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                3/48 (6%)                2/49 (4%)                0/49 (0%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  3/42.69                  2/42.70                  0/45.10         | 
|POLY-3 PERCENT (g) |                  0.0%                     7.0%                     4.7%                     0.0%            | 
|TERMINAL (d)       |                  0/36 (0%)                2/36 (6%)                1/33 (3%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  ---                      689                      707                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.398N                 P=0.117                  P=0.216                  (e)             | 
|POLY 3             |                  P=0.408N                 P=0.107                  P=0.223                  (e)             | 
|POLY 1.5           |                  P=0.409N                 P=0.108                  P=0.227                  (e)             | 
|POLY 6             |                  P=0.407N                 P=0.107                  P=0.219                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.408N                 P=0.109                  P=0.219                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.412N                 P=0.114                  P=0.242                  (e)             | 
|ORDER RESTRICTED   |                  P=0.206                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/47 (4%)                0/48 (0%)                0/46 (0%)                1/47 (2%)       | 
|POLY-3 RATE (b)    |                  2/42.53                  0/41.54                  0/40.04                  1/42.46         | 
|POLY-3 PERCENT (g) |                  4.7%                     0.0%                     0.0%                     2.4%            | 
|TERMINAL (d)       |                  1/33 (3%)                0/34 (0%)                0/31 (0%)                1/36 (3%)       | 
|FIRST INCIDENCE    |                  715                      ---                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.450N                 P=0.248N                 P=0.268N                 P=0.483N        | 
|POLY 3             |                  P=0.458N                 P=0.242N                 P=0.251N                 P=0.501N        | 
|POLY 1.5           |                  P=0.460N                 P=0.239N                 P=0.247N                 P=0.500N        | 
|POLY 6             |                  P=0.456N                 P=0.246N                 P=0.255N                 P=0.501N        | 
|LOGISTIC REGRESSION|                  P=0.459N                 P=0.247N                 P=0.255N                 P=0.499N        | 
|COCH-ARM / FISHERS |                  P=0.463N                 P=0.242N                 P=0.253N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.133N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Peripheral Nerve                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/5 (60%)                2/4 (50%)                0/1 (0%)                 0/1 (0%)        | 
|POLY-3 RATE (b)    |                  3/4.35                   2/3.21                   0/0.40                   0/0.77          | 
|POLY-3 PERCENT (g) |                  69.0%                    62.3%                    0.0%                     0.0%            | 
|TERMINAL (d)       |                  1/1 (100%)               0/0 (0%)                 0/0 (0%)                 0/0 (0%)        | 
|FIRST INCIDENCE    |                  423                      318                      ---                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.091N                 P=0.677                  P=0.259N                 P=0.241N        | 
|POLY 3             |                  P=0.348N                 P=0.719N                 P=0.723N                 P=0.546N        | 
|POLY 1.5           |                  P=0.292N                 P=0.673N                 P=0.620N                 P=0.519N        | 
|POLY 6             |                  P=0.470N                 P=0.812N                 P=0.863N                 P=0.622N        | 
|LOGISTIC REGRESSION|                  P=0.209N                 P=0.600N                 P=0.527N                 P=0.516N        | 
|COCH-ARM / FISHERS |                  P=0.211N                 P=0.643N                 P=0.500N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.365N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/49 (2%)                4/50 (8%)                0/49 (0%)                3/49 (6%)       | 
|POLY-3 RATE (b)    |                  1/44.47                  4/44.27                  0/43.23                  3/44.63         | 
|POLY-3 PERCENT (g) |                  2.3%                     9.0%                     0.0%                     6.7%            | 
|TERMINAL (d)       |                  1/35 (3%)                2/36 (6%)                0/33 (0%)                3/39 (8%)       | 
|FIRST INCIDENCE    |                  729 (T)                  547                      ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.434                  P=0.180                  P=0.512N                 P=0.344         | 
|POLY 3             |                  P=0.399                  P=0.177                  P=0.506N                 P=0.306         | 
|POLY 1.5           |                  P=0.400                  P=0.179                  P=0.503N                 P=0.306         | 
|POLY 6             |                  P=0.398                  P=0.175                  P=0.509N                 P=0.307         | 
|LOGISTIC REGRESSION|                  P=0.403                  P=0.188                  (e)                      P=0.344         | 
|COCH-ARM / FISHERS |                  P=0.401                  P=0.187                  P=0.500N                 P=0.309         | 
|ORDER RESTRICTED   |                  P=0.242                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/49 (12%)               6/50 (12%)               1/49 (2%)                4/49 (8%)       | 
|POLY-3 RATE (b)    |                  6/44.47                  6/43.54                  1/43.32                  4/44.86         | 
|POLY-3 PERCENT (g) |                  13.5%                    13.8%                    2.3%                     8.9%            | 
|TERMINAL (d)       |                  6/35 (17%)               6/36 (17%)               0/33 (0%)                3/39 (8%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  707                      669             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.175N                 P=0.603N                 P=0.071N                 P=0.310N        | 
|POLY 3             |                  P=0.203N                 P=0.606                  P=0.060N                 P=0.364N        | 
|POLY 1.5           |                  P=0.205N                 P=0.615                  P=0.058N                 P=0.366N        | 
|POLY 6             |                  P=0.200N                 P=0.596                  P=0.062N                 P=0.359N        | 
|LOGISTIC REGRESSION|                  P=0.198N                 P=0.603N                 P=0.070N                 P=0.363N        | 
|COCH-ARM / FISHERS |                  P=0.210N                 P=0.606N                 P=0.056N                 P=0.370N        | 
|ORDER RESTRICTED   |                  P=0.152N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  25/50 (50%)              22/50 (44%)              26/50 (52%)              20/50 (40%)     | 
|POLY-3 RATE (b)    |                  25/47.10                 22/45.04                 26/44.45                 20/46.17        | 
|POLY-3 PERCENT (g) |                  53.1%                    48.9%                    58.5%                    43.3%           | 
|TERMINAL (d)       |                  20/36 (56%)              18/36 (50%)              23/33 (70%)              18/39 (46%)     | 
|FIRST INCIDENCE    |                  563                      521                      539                      587             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.151N                 P=0.373N                 P=0.327                  P=0.142N        | 
|POLY 3             |                  P=0.233N                 P=0.421N                 P=0.376                  P=0.229N        | 
|POLY 1.5           |                  P=0.226N                 P=0.395N                 P=0.428                  P=0.219N        | 
|POLY 6             |                  P=0.243N                 P=0.457N                 P=0.312                  P=0.243N        | 
|LOGISTIC REGRESSION|                  P=0.210N                 P=0.402N                 P=0.401                  P=0.207N        | 
|COCH-ARM / FISHERS |                  P=0.229N                 P=0.344N                 P=0.500                  P=0.211N        | 
|ORDER RESTRICTED   |                  P=0.250N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/50 (0%)                0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/46.13                  0/43.54                  0/43.48                  1/45.81         | 
|POLY-3 PERCENT (g) |                  4.3%                     0.0%                     0.0%                     2.2%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  606                      ---                      ---                      631             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.456N                 P=0.256N                 P=0.258N                 P=0.497N        | 
|POLY 3             |                  P=0.455N                 P=0.250N                 P=0.251N                 P=0.502N        | 
|POLY 1.5           |                  P=0.457N                 P=0.246N                 P=0.245N                 P=0.501N        | 
|POLY 6             |                  P=0.453N                 P=0.256N                 P=0.258N                 P=0.504N        | 
|LOGISTIC REGRESSION|                  P=0.476N                 P=0.209N                 P=0.216N                 P=0.517N        | 
|COCH-ARM / FISHERS |                  P=0.461N                 P=0.247N                 P=0.247N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.135N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  42/50 (84%)              30/49 (61%)              32/48 (67%)              29/50 (58%)     | 
|POLY-3 RATE (b)    |                  42/48.25                 30/47.57                 32/45.99                 29/47.84        | 
|POLY-3 PERCENT (g) |                  87.1%                    63.1%                    69.6%                    60.6%           | 
|TERMINAL (d)       |                  31/36 (86%)              20/36 (56%)              20/32 (63%)              23/39 (59%)     | 
|FIRST INCIDENCE    |                  563                      318                      455                      472             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.022N*                P=0.043N*                P=0.197N                 P=0.006N**      | 
|POLY 3             |                  P=0.010N*                P=0.005N**               P=0.031N*                P=0.002N**      | 
|POLY 1.5           |                  P=0.010N*                P=0.006N**               P=0.031N*                P=0.002N**      | 
|POLY 6             |                  P=0.013N*                P=0.005N**               P=0.033N*                P=0.003N**      | 
|LOGISTIC REGRESSION|                  P=0.012N*                P=0.012N*                P=0.049N*                P=0.004N**      | 
|COCH-ARM / FISHERS |                  P=0.013N*                P=0.010N*                P=0.039N*                P=0.004N**      | 
|ORDER RESTRICTED   |                  P=0.002N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  3/50 (6%)                1/49 (2%)                2/48 (4%)                3/50 (6%)       | 
|POLY-3 RATE (b)    |                  3/45.47                  1/43.17                  2/41.61                  3/45.46         | 
|POLY-3 PERCENT (g) |                  6.6%                     2.3%                     4.8%                     6.6%            | 
|TERMINAL (d)       |                  3/36 (8%)                1/36 (3%)                2/32 (6%)                3/39 (8%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.510                  P=0.305N                 P=0.554N                 P=0.626N        | 
|POLY 3             |                  P=0.484                  P=0.324N                 P=0.540N                 P=0.662         | 
|POLY 1.5           |                  P=0.483                  P=0.321N                 P=0.532N                 P=0.662N        | 
|POLY 6             |                  P=0.485                  P=0.328N                 P=0.551N                 P=0.662         | 
|LOGISTIC REGRESSION|                  P=0.510                  P=0.305N                 P=0.554N                 P=0.626N        | 
|COCH-ARM / FISHERS |                  P=0.478                  P=0.316N                 P=0.520N                 P=0.661N        | 
|ORDER RESTRICTED   |                  P=0.509                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  29/50 (58%)              22/49 (45%)              30/48 (63%)              27/50 (54%)     | 
|POLY-3 RATE (b)    |                  29/47.49                 22/44.67                 30/44.68                 27/47.62        | 
|POLY-3 PERCENT (g) |                  61.1%                    49.3%                    67.2%                    56.7%           | 
|TERMINAL (d)       |                  23/36 (64%)              19/36 (53%)              20/32 (63%)              22/39 (56%)     | 
|FIRST INCIDENCE    |                  350                      318                      486                      424             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.449N                 P=0.135N                 P=0.288                  P=0.305N        | 
|POLY 3             |                  P=0.535N                 P=0.172N                 P=0.346                  P=0.411N        | 
|POLY 1.5           |                  P=0.533                  P=0.159N                 P=0.359                  P=0.414N        | 
|POLY 6             |                  P=0.519N                 P=0.193N                 P=0.345                  P=0.409N        | 
|LOGISTIC REGRESSION|                  P=0.515                  P=0.152N                 P=0.354                  P=0.419N        | 
|COCH-ARM / FISHERS |                  P=0.505                  P=0.135N                 P=0.402                  P=0.420N        | 
|ORDER RESTRICTED   |                  P=0.404                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  5/50 (10%)               8/49 (16%)               13/48 (27%)              14/50 (28%)     | 
|POLY-3 RATE (b)    |                  5/45.97                  8/43.17                  13/41.81                 14/45.57        | 
|POLY-3 PERCENT (g) |                  10.9%                    18.5%                    31.1%                    30.7%           | 
|TERMINAL (d)       |                  4/36 (11%)               8/36 (22%)               11/32 (34%)              13/39 (33%)     | 
|FIRST INCIDENCE    |                  581                      729 (T)                  701                      703             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.019 *                P=0.272                  P=0.018 *                P=0.030 *       | 
|POLY 3             |                  P=0.010 *                P=0.235                  P=0.017 *                P=0.016 *       | 
|POLY 1.5           |                  P=0.011 *                P=0.244                  P=0.020 *                P=0.018 *       | 
|POLY 6             |                  P=0.009 **               P=0.224                  P=0.014 *                P=0.015 *       | 
|LOGISTIC REGRESSION|                  P=0.012 *                P=0.238                  P=0.017 *                P=0.020 *       | 
|COCH-ARM / FISHERS |                  P=0.012 *                P=0.264                  P=0.026 *                P=0.020 *       | 
|ORDER RESTRICTED   |                  P=0.011 *                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                1/49 (2%)                2/50 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/46.04                  1/43.67                  2/44.10                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.3%                     2.3%                     4.5%                     0.0%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  563                      581                      583                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.206N                 P=0.519N                 P=0.662                  P=0.242N        | 
|POLY 3             |                  P=0.200N                 P=0.518N                 P=0.678                  P=0.240N        | 
|POLY 1.5           |                  P=0.199N                 P=0.515N                 P=0.684                  P=0.239N        | 
|POLY 6             |                  P=0.201N                 P=0.522N                 P=0.671                  P=0.242N        | 
|LOGISTIC REGRESSION|                  P=0.206N                 P=0.460N                 P=0.667N                 P=0.245N        | 
|COCH-ARM / FISHERS |                  P=0.199N                 P=0.508N                 P=0.691N                 P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.157N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                4/49 (8%)                0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  4/45.38                  0/43.48                  1/46.10         | 
|POLY-3 PERCENT (g) |                  0.0%                     8.8%                     0.0%                     2.2%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  ---                      318                      ---                      522             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.529N                 P=0.063                  (e)                      P=0.500         | 
|POLY 3             |                  P=0.526N                 P=0.060                  (e)                      P=0.503         | 
|POLY 1.5           |                  P=0.527N                 P=0.059                  (e)                      P=0.502         | 
|POLY 6             |                  P=0.525N                 P=0.061                  (e)                      P=0.504         | 
|LOGISTIC REGRESSION|                  P=0.617N                 P=0.085                  (e)                      P=0.438         | 
|COCH-ARM / FISHERS |                  P=0.528N                 P=0.056                  (e)                      P=0.500         | 
|ORDER RESTRICTED   |                  P=0.212                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                0/49 (0%)                2/50 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  0/43.17                  2/44.06                  0/45.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     0.0%                     4.5%                     0.0%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  ---                      ---                      583                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.594                  (e)                      P=0.223                  (e)             | 
|POLY 3             |                  P=0.603                  (e)                      P=0.230                  (e)             | 
|POLY 1.5           |                  P=0.602                  (e)                      P=0.233                  (e)             | 
|POLY 6             |                  P=0.605                  (e)                      P=0.227                  (e)             | 
|LOGISTIC REGRESSION|                  P=0.589                  (e)                      P=0.253                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.596                  (e)                      P=0.247                  (e)             | 
|ORDER RESTRICTED   |                  P=0.241                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                3/49 (6%)                4/50 (8%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  2/45.99                  3/44.89                  4/43.57                  2/46.70         | 
|POLY-3 PERCENT (g) |                  4.4%                     6.7%                     9.2%                     4.3%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/36 (0%)                3/33 (9%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  581                      318                      707                      522             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.549N                 P=0.483                  P=0.298                  P=0.690         | 
|POLY 3             |                  P=0.551N                 P=0.489                  P=0.312                  P=0.688N        | 
|POLY 1.5           |                  P=0.553N                 P=0.489                  P=0.323                  P=0.690N        | 
|POLY 6             |                  P=0.549N                 P=0.488                  P=0.300                  P=0.687N        | 
|LOGISTIC REGRESSION|                  P=0.574                  P=0.599                  P=0.330                  P=0.672         | 
|COCH-ARM / FISHERS |                  P=0.559N                 P=0.490                  P=0.339                  P=0.691N        | 
|ORDER RESTRICTED   |                  P=0.493N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/49 (0%)                2/49 (4%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  2/45.63                  0/43.17                  2/42.87                  0/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     4.7%                     0.0%            | 
|TERMINAL (d)       |                  1/36 (3%)                0/36 (0%)                1/33 (3%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  689                      ---                      659                      ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.243N                 P=0.251N                 P=0.663                  P=0.234N        | 
|POLY 3             |                  P=0.242N                 P=0.250N                 P=0.671                  P=0.238N        | 
|POLY 1.5           |                  P=0.243N                 P=0.247N                 P=0.677                  P=0.237N        | 
|POLY 6             |                  P=0.241N                 P=0.253N                 P=0.664                  P=0.239N        | 
|LOGISTIC REGRESSION|                  P=0.247N                 P=0.247N                 P=0.682                  P=0.237N        | 
|COCH-ARM / FISHERS |                  P=0.247N                 P=0.253N                 P=0.684                  P=0.247N        | 
|ORDER RESTRICTED   |                  P=0.116N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                0/49 (0%)                1/49 (2%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/46.01                  0/43.17                  1/43.10                  1/45.63         | 
|POLY-3 PERCENT (g) |                  4.4%                     0.0%                     2.3%                     2.2%            | 
|TERMINAL (d)       |                  1/36 (3%)                0/36 (0%)                0/33 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  563                      ---                      583                      686             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.494N                 P=0.247N                 P=0.520N                 P=0.496N        | 
|POLY 3             |                  P=0.494N                 P=0.252N                 P=0.523N                 P=0.503N        | 
|POLY 1.5           |                  P=0.495N                 P=0.248N                 P=0.517N                 P=0.501N        | 
|POLY 6             |                  P=0.492N                 P=0.255N                 P=0.530N                 P=0.504N        | 
|LOGISTIC REGRESSION|                  P=0.514N                 P=0.220N                 P=0.469N                 P=0.508N        | 
|COCH-ARM / FISHERS |                  P=0.499N                 P=0.253N                 P=0.508N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.282N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  9/49 (18%)               3/49 (6%)                6/50 (12%)               4/47 (9%)       | 
|POLY-3 RATE (b)    |                  9/47.71                  3/44.86                  6/45.14                  4/44.81         | 
|POLY-3 PERCENT (g) |                  18.9%                    6.7%                     13.3%                    8.9%            | 
|TERMINAL (d)       |                  2/36 (6%)                1/36 (3%)                1/33 (3%)                0/37 (0%)       | 
|FIRST INCIDENCE    |                  350                      318                      539                      424             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.173N                 P=0.085N                 P=0.357N                 P=0.133N        | 
|POLY 3             |                  P=0.173N                 P=0.074N                 P=0.328N                 P=0.141N        | 
|POLY 1.5           |                  P=0.174N                 P=0.068N                 P=0.308N                 P=0.137N        | 
|POLY 6             |                  P=0.172N                 P=0.085N                 P=0.352N                 P=0.147N        | 
|LOGISTIC REGRESSION|                  P=0.146N                 P=0.029N*                P=0.187N                 P=0.069N        | 
|COCH-ARM / FISHERS |                  P=0.176N                 P=0.060N                 P=0.274N                 P=0.133N        | 
|ORDER RESTRICTED   |                  P=0.105N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  1/49 (2%)                3/49 (6%)                4/50 (8%)                2/47 (4%)       | 
|POLY-3 RATE (b)    |                  1/44.77                  3/43.51                  4/43.48                  2/42.63         | 
|POLY-3 PERCENT (g) |                  2.2%                     6.9%                     9.2%                     4.7%            | 
|TERMINAL (d)       |                  1/36 (3%)                3/36 (8%)                4/33 (12%)               2/37 (5%)       | 
|FIRST INCIDENCE    |                  729 (T)                  729 (T)                  729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.466                  P=0.305                  P=0.153                  P=0.510         | 
|POLY 3             |                  P=0.434                  P=0.295                  P=0.170                  P=0.483         | 
|POLY 1.5           |                  P=0.436                  P=0.300                  P=0.176                  P=0.484         | 
|POLY 6             |                  P=0.433                  P=0.288                  P=0.161                  P=0.481         | 
|LOGISTIC REGRESSION|                  P=0.466                  P=0.305                  P=0.153                  P=0.510         | 
|COCH-ARM / FISHERS |                  P=0.437                  P=0.309                  P=0.187                  P=0.484         | 
|ORDER RESTRICTED   |                  P=0.272                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  26/50 (52%)              17/49 (35%)              12/49 (24%)              11/50 (22%)     | 
|POLY-3 RATE (b)    |                  26/48.04                 17/43.65                 12/43.33                 11/46.04        | 
|POLY-3 PERCENT (g) |                  54.1%                    39.0%                    27.7%                    23.9%           | 
|TERMINAL (d)       |                  19/36 (53%)              14/35 (40%)              9/33 (27%)               9/39 (23%)      | 
|FIRST INCIDENCE    |                  423                      521                      663                      631             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P<0.001N**               P=0.085N                 P=0.014N*                P=0.002N**      | 
|POLY 3             |                  P<0.001N**               P=0.104N                 P=0.008N**               P=0.002N**      | 
|POLY 1.5           |                  P<0.001N**               P=0.087N                 P=0.006N**               P<0.001N**      | 
|POLY 6             |                  P<0.001N**               P=0.126N                 P=0.011N*                P=0.002N**      | 
|LOGISTIC REGRESSION|                  P<0.001N**               P=0.074N                 P=0.005N**               P=0.002N**      | 
|COCH-ARM / FISHERS |                  P<0.001N**               P=0.062N                 P=0.004N**               P=0.002N**      | 
|ORDER RESTRICTED   |                  P<0.001N**               (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  6/50 (12%)               1/49 (2%)                5/49 (10%)               1/50 (2%)       | 
|POLY-3 RATE (b)    |                  6/46.00                  1/42.54                  5/43.29                  1/45.46         | 
|POLY-3 PERCENT (g) |                  13.0%                    2.4%                     11.6%                    2.2%            | 
|TERMINAL (d)       |                  4/36 (11%)               1/35 (3%)                3/33 (9%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  649                      729 (T)                  604                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.089N                 P=0.069N                 P=0.552N                 P=0.053N        | 
|POLY 3             |                  P=0.087N                 P=0.069N                 P=0.542N                 P=0.058N        | 
|POLY 1.5           |                  P=0.089N                 P=0.066N                 P=0.531N                 P=0.057N        | 
|POLY 6             |                  P=0.086N                 P=0.074N                 P=0.556N                 P=0.059N        | 
|LOGISTIC REGRESSION|                  P=0.094N                 P=0.067N                 P=0.523N                 P=0.058N        | 
|COCH-ARM / FISHERS |                  P=0.095N                 P=0.059N                 P=0.514N                 P=0.056N        | 
|ORDER RESTRICTED   |                  P=0.028N*                (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                2/49 (4%)                0/48 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  2/43.54                  0/41.61                  1/45.81         | 
|POLY-3 PERCENT (g) |                  0.0%                     4.6%                     0.0%                     2.2%            | 
|TERMINAL (d)       |                  0/36 (0%)                0/35 (0%)                0/32 (0%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  ---                      521                      ---                      631             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.544                  P=0.237                  (e)                      P=0.504         | 
|POLY 3             |                  P=0.539                  P=0.227                  (e)                      P=0.501         | 
|POLY 1.5           |                  P=0.539                  P=0.229                  (e)                      P=0.501         | 
|POLY 6             |                  P=0.540                  P=0.226                  (e)                      P=0.502         | 
|LOGISTIC REGRESSION|                  P=0.506                  P=0.285                  (e)                      P=0.488         | 
|COCH-ARM / FISHERS |                  P=0.539                  P=0.242                  (e)                      P=0.500         | 
|ORDER RESTRICTED   |                  P=0.308                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  11/50 (22%)              7/49 (14%)               4/48 (8%)                10/50 (20%)     | 
|POLY-3 RATE (b)    |                  11/45.47                 7/43.27                  4/41.61                  10/45.46        | 
|POLY-3 PERCENT (g) |                  24.2%                    16.2%                    9.6%                     22.0%           | 
|TERMINAL (d)       |                  11/36 (31%)              5/35 (14%)               4/32 (13%)               10/39 (26%)     | 
|FIRST INCIDENCE    |                  729 (T)                  547                      729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.431N                 P=0.239N                 P=0.068N                 P=0.415N        | 
|POLY 3             |                  P=0.495N                 P=0.250N                 P=0.063N                 P=0.500N        | 
|POLY 1.5           |                  P=0.494N                 P=0.246N                 P=0.059N                 P=0.499N        | 
|POLY 6             |                  P=0.496N                 P=0.254N                 P=0.068N                 P=0.501N        | 
|LOGISTIC REGRESSION|                  P=0.484N                 P=0.270N                 P=0.068N                 P=0.415N        | 
|COCH-ARM / FISHERS |                  P=0.498N                 P=0.232N                 P=0.054N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.242N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                3/50 (6%)                1/50 (2%)                0/50 (0%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  3/43.54                  1/43.48                  0/45.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     6.9%                     2.3%                     0.0%            | 
|TERMINAL (d)       |                  0/36 (0%)                3/36 (8%)                1/33 (3%)                0/39 (0%)       | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  729 (T)                  ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.348N                 P=0.121                  P=0.483                  (e)             | 
|POLY 3             |                  P=0.371N                 P=0.111                  P=0.491                  (e)             | 
|POLY 1.5           |                  P=0.369N                 P=0.114                  P=0.495                  (e)             | 
|POLY 6             |                  P=0.374N                 P=0.108                  P=0.486                  (e)             | 
|LOGISTIC REGRESSION|                  (e)                      P=0.121                  P=0.483                  (e)             | 
|COCH-ARM / FISHERS |                  P=0.366N                 P=0.121                  P=0.500                  (e)             | 
|ORDER RESTRICTED   |                  P=0.211N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  45/50 (90%)              45/50 (90%)              43/50 (86%)              46/50 (92%)     | 
|POLY-3 RATE (b)    |                  45/48.59                 45/48.66                 43/48.08                 46/48.24        | 
|POLY-3 PERCENT (g) |                  92.6%                    92.5%                    89.4%                    95.4%           | 
|TERMINAL (d)       |                  34/36 (94%)              33/36 (92%)              31/33 (94%)              38/39 (97%)     | 
|FIRST INCIDENCE    |                  423                      318                      455                      522             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.387N                 P=0.524                  P=0.442                  P=0.429N        | 
|POLY 3             |                  P=0.374                  P=0.646N                 P=0.419N                 P=0.440         | 
|POLY 1.5           |                  P=0.414                  P=0.637                  P=0.399N                 P=0.467         | 
|POLY 6             |                  P=0.338                  P=0.621N                 P=0.455N                 P=0.424         | 
|LOGISTIC REGRESSION|                  P=0.502                  P=0.539                  P=0.454N                 P=0.517         | 
|COCH-ARM / FISHERS |                  P=0.453                  P=0.630N                 P=0.380N                 P=0.500         | 
|ORDER RESTRICTED   |                  P=0.355                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  2/50 (4%)                2/50 (4%)                0/50 (0%)                1/50 (2%)       | 
|POLY-3 RATE (b)    |                  2/45.53                  2/43.54                  0/43.48                  1/45.46         | 
|POLY-3 PERCENT (g) |                  4.4%                     4.6%                     0.0%                     2.2%            | 
|TERMINAL (d)       |                  1/36 (3%)                2/36 (6%)                0/33 (0%)                1/39 (3%)       | 
|FIRST INCIDENCE    |                  715                      729 (T)                  ---                      729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.285N                 P=0.684                  P=0.271N                 P=0.484N        | 
|POLY 3             |                  P=0.298N                 P=0.678                  P=0.248N                 P=0.501N        | 
|POLY 1.5           |                  P=0.297N                 P=0.683                  P=0.243N                 P=0.500N        | 
|POLY 6             |                  P=0.299N                 P=0.672                  P=0.253N                 P=0.501N        | 
|LOGISTIC REGRESSION|                  P=0.294N                 P=0.669                  P=0.255N                 P=0.500N        | 
|COCH-ARM / FISHERS |                  P=0.296N                 P=0.691N                 P=0.247N                 P=0.500N        | 
|ORDER RESTRICTED   |                  P=0.259N                 (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/25/03                           EXPERIMENT: 96018 TEST: 04                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -   WATER DISINFECTION BYPRODUCTS (BROMODICHL                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                  0 MG/L                   175 MG/L                 350 MG/L                 700 MG/L        | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                  0/50 (0%)                1/50 (2%)                2/50 (4%)                2/50 (4%)       | 
|POLY-3 RATE (b)    |                  0/45.47                  1/43.54                  2/43.48                  2/45.46         | 
|POLY-3 PERCENT (g) |                  0.0%                     2.3%                     4.6%                     4.4%            | 
|TERMINAL (d)       |                  0/36 (0%)                1/36 (3%)                2/33 (6%)                2/39 (5%)       | 
|FIRST INCIDENCE    |                  ---                      729 (T)                  729 (T)                  729 (T)         | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                  P=0.181                  P=0.500                  P=0.219                  P=0.256         | 
|POLY 3             |                  P=0.163                  P=0.491                  P=0.227                  P=0.237         | 
|POLY 1.5           |                  P=0.163                  P=0.494                  P=0.231                  P=0.237         | 
|POLY 6             |                  P=0.164                  P=0.488                  P=0.222                  P=0.237         | 
|LOGISTIC REGRESSION|                  (e)                      P=0.500                  P=0.219                  P=0.256         | 
|COCH-ARM / FISHERS |                  P=0.160                  P=0.500                  P=0.247                  P=0.247         | 
|ORDER RESTRICTED   |                  P=0.147                  (e)                      (e)                      (e)             | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.