Share This:
https://ntp.niehs.nih.gov/go/16818

TDMS Study 96018-04 Pathology Tables

NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/25/03
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 11:09:28

                                                         FINAL #1/MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  75-27-4

       Lock Date:  02/18/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/25/03    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 11:09:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            7           12            7                                     
    Moribund Sacrifice                                 7            6            5            4                                     
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           36           33           39                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (48)         (48)         (49)                                   
      Edema                                           10 [2.0]      8 [2.1]      8 [2.0]      4 [2.0]                               
      Hemorrhage                                       1 [4.0]                                                                      
   Intestine Small, Duodenum                          (48)         (48)         (46)         (46)                                   
      Cyst                                             1 [3.0]                                                                      
      Inflammation, Chronic                            1 [3.0]                   1 [2.0]                                            
      Epithelium, Hyperplasia                          1 [3.0]      1 [3.0]      2 [3.0]                                            
   Intestine Small, Jejunum                           (46)         (49)         (48)         (48)                                   
      Hyperplasia, Lymphoid                                                                   1 [3.0]                               
      Epithelium, Hyperplasia                                                    1 [3.0]                                            
   Intestine Small, Ileum                             (45)         (46)         (49)         (49)                                   
      Diverticulum                                                               1                                                  
      Epithelium, Hyperplasia                                       1 [3.0]      2 [3.0]                                            
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                 3                         5            2                                     
      Clear Cell Focus                                 2            1            2            3                                     
      Cyst                                             2 [3.0]                                                                      
      Eosinophilic Focus                               7            4            8            4                                     
      Hematopoietic Cell Proliferation                 4 [2.8]      2 [3.0]      1 [2.0]      1 [2.0]                               
      Hyperplasia, Lymphoid                            2 [2.0]      5 [2.0]      6 [2.0]      1 [1.0]                               
      Infarct                                                                                 2 [3.5]                               
      Infiltration Cellular, Mixed Cell                6 [2.3]      6 [2.2]      7 [1.9]      5 [2.0]                               
      Mixed Cell Focus                                 3            3            3            2                                     
      Necrosis, Focal                                  3 [1.0]      5 [2.0]      2 [2.0]      4 [1.3]                               
      Tension Lipidosis                                2                                      2                                     
      Centrilobular, Necrosis                          6 [2.3]      1 [3.0]      2 [2.5]      3 [2.7]                               
      Hepatocyte, Depletion Glycogen                   3 [3.0]      2 [3.0]      1 [3.0]                                            
      Hepatocyte, Karyomegaly                          2 [2.0]      4 [2.0]                                                         
      Hepatocyte, Vacuolization Cytoplasmic            6 [3.0]      3 [3.3]      6 [3.0]      3 [3.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/25/03    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 11:09:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Kupffer Cell, Hyperplasia                        2 [2.5]      1 [2.0]                                                         
      Kupffer Cell, Pigmentation                       7 [2.0]                   2 [2.0]      1 [2.0]                               
   Mesentery                                          (21)         (17)         (16)         (17)                                   
      Angiectasis                                      1 [3.0]                                                                      
      Hemorrhage                                                    2 [2.5]                                                         
      Necrosis                                         1 [2.0]                                                                      
      Fat, Necrosis                                   12 [3.4]      8 [3.1]     11 [3.5]     13 [3.0]                               
   Pancreas                                           (50)         (48)         (49)         (49)                                   
      Atrophy                                          1 [2.0]      2 [3.5]      2 [2.0]                                            
      Cyst                                                          1 [3.0]      1 [3.0]                                            
      Acinus, Cytoplasmic Alteration                                3 [3.0]      2 [3.5]                                            
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                    1 [3.0]                                            
      Hyperplasia, Lymphoid                           25 [2.2]     22 [2.4]     26 [2.2]     20 [2.4]                               
   Stomach, Forestomach                               (50)         (49)         (50)         (50)                                   
      Edema                                            2 [2.0]      1 [2.0]      2 [3.0]                                            
      Erosion                                          1 [2.0]                                1 [2.0]                               
      Hemorrhage                                                                              1 [2.0]                               
      Inflammation, Chronic Active                                  4 [1.8]                   1 [2.0]                               
      Ulcer                                                                      2 [2.0]                                            
      Epithelium, Hyperplasia                          2 [2.0]      3 [1.7]      4 [1.8]      2 [2.0]                               
   Stomach, Glandular                                 (50)         (49)         (49)         (50)                                   
      Cyst                                             2 [2.5]                   2 [3.0]                                            
      Edema                                            2 [2.0]                   1 [2.0]      1 [2.0]                               
      Erosion                                          1 [2.0]      1 [2.0]      1 [3.0]                                            
   Tooth                                                                        (1)                                                 
      Malformation                                                               1                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 [4.0]      1 [2.0]                   1 [1.0]                               
      Mineralization                                   3 [1.7]                                                                      
      Thrombosis                                                    1 [2.0]                   1 [3.0]                               
      Artery, Inflammation, Chronic                                 1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (49)                                   
      Accessory Adrenal Cortical Nodule                8 [3.0]      5 [3.0]      5 [3.0]     10 [3.0]                               
      Hyperplasia, Focal                               1 [2.0]      1 [3.0]                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/25/03    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 11:09:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hypertrophy, Focal                               1 [3.0]      1 [2.0]      2 [1.5]                                            
      Zona Reticularis, Vacuolization Cytoplasmic                   2 [3.0]      1 [4.0]                                            
   Adrenal Medulla                                    (50)         (48)         (49)         (49)                                   
      Hyperplasia                                      2 [1.5]                                2 [1.5]                               
   Islets, Pancreatic                                 (49)         (48)         (48)         (49)                                   
      Hyperplasia                                      1 [2.0]      4 [2.3]      3 [2.0]      1 [2.0]                               
   Parathyroid Gland                                  (47)         (48)         (46)         (47)                                   
      Cyst                                             2 [3.0]                                1 [3.0]                               
   Pituitary Gland                                    (49)         (50)         (49)         (49)                                   
      Pars Distalis, Angiectasis                       1 [2.0]                   1 [2.0]      1 [2.0]                               
      Pars Distalis, Cyst                              1 [3.0]      4 [3.0]                   3 [3.0]                               
      Pars Distalis, Hyperplasia, Focal                6 [1.8]      6 [1.5]      1 [2.0]      4 [1.5]                               
   Thyroid Gland                                      (50)         (49)         (49)         (50)                                   
      Degeneration, Cystic                            26 [1.9]     17 [1.7]     12 [1.8]     11 [2.1]                               
      Follicular Cell, Hyperplasia                     6 [1.3]      1 [2.0]      5 [1.4]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (49)         (48)         (49)                                   
      Inflammation, Chronic                            1 [3.0]      1 [2.0]      4 [2.3]      1 [2.0]                               
   Ovary                                              (50)         (49)         (50)         (49)                                   
      Angiectasis                                      5 [2.6]      6 [2.5]      5 [2.6]      9 [2.2]                               
      Cyst                                             8 [3.0]     13 [3.0]     11 [3.0]     14 [3.0]                               
      Thrombosis                                       1 [4.0]                                1 [3.0]                               
      Corpus Luteum, Hyperplasia                       3 [2.0]      1 [2.0]      3 [2.7]                                            
      Granulosa Cell, Hyperplasia                                                             2 [2.0]                               
      Interstitial Cell, Hyperplasia                   1 [2.0]      1 [3.0]      1 [2.0]      1 [2.0]                               
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                                   3 [3.3]      1 [4.0]                                            
      Hyperplasia, Cystic                             45 [3.2]     45 [3.1]     43 [3.4]     46 [3.2]                               
      Inflammation, Chronic                            2 [2.0]      2 [2.5]                   1 [3.0]                               
      Metaplasia, Squamous                                          1 [3.0]      2 [3.0]      2 [2.5]                               
      Endometrium, Hyperplasia, Atypical                                                      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/25/03    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 11:09:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     22 [2.6]     24 [2.9]     18 [2.9]     11 [2.6]                               
      Myelofibrosis                                    3 [2.0]      1 [2.0]      1 [3.0]                                            
   Lymph Node                                         (16)         (9)          (7)          (4)                                    
      Iliac, Hemorrhage                                1 [4.0]                   1 [4.0]                                            
      Iliac, Hyperplasia, Lymphoid                     3 [3.0]                                                                      
      Mediastinal, Hemorrhage                          1 [3.0]      1 [2.0]                                                         
      Renal, Hyperplasia, Lymphoid                                                            1 [3.0]                               
   Lymph Node, Mandibular                             (50)         (50)         (50)         (47)                                   
      Atrophy                                          2 [3.0]                   1 [3.0]      1 [3.0]                               
      Hematopoietic Cell Proliferation                 1 [2.0]      2 [2.0]                   1 [1.0]                               
      Hemorrhage                                                    3 [1.7]      2 [3.0]      3 [1.7]                               
      Hyperplasia, Lymphoid                            8 [2.4]      9 [2.4]      6 [2.8]      9 [2.4]                               
      Pigmentation                                    22 [2.4]     27 [2.2]     25 [2.3]     20 [2.2]                               
   Lymph Node, Mesenteric                             (49)         (48)         (46)         (50)                                   
      Atrophy                                          1 [3.0]                                2 [3.0]                               
      Hematopoietic Cell Proliferation                                           2 [1.5]      2 [2.5]                               
      Hemorrhage                                       3 [2.7]      2 [3.5]      3 [3.7]                                            
      Hyperplasia, Lymphoid                            6 [2.5]      9 [2.4]      4 [2.5]      7 [2.3]                               
      Pigmentation                                     1 [3.0]                   1 [2.0]                                            
   Spleen                                             (50)         (49)         (48)         (50)                                   
      Hematopoietic Cell Proliferation                42 [2.7]     30 [2.8]     32 [2.5]     29 [2.3]                               
      Hemorrhage                                                    1 [3.0]                   1 [4.0]                               
      Hyperplasia, Lymphoid                            3 [2.3]      1 [3.0]      2 [3.0]      3 [3.0]                               
      Metaplasia, Osseous                                                                     1 [2.0]                               
      Pigmentation                                    29 [2.3]     22 [2.0]     30 [2.4]     27 [2.2]                               
      Lymphoid Follicle, Atrophy                                                 1 [3.0]      1 [3.0]                               
      Lymphoid Follicle, Hyperplasia                   5 [2.6]      8 [2.6]     13 [2.7]     14 [2.5]                               
   Thymus                                             (49)         (49)         (50)         (47)                                   
      Atrophy                                          9 [2.9]      3 [3.0]      6 [2.7]      4 [3.0]                               
      Hyperplasia, Lymphoid                            1 [2.0]      3 [2.7]      4 [2.8]      2 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      9 [1.7]      4 [1.3]      4 [2.0]      2 [2.0]                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 [3.0]                                                                      
      Edema                                            2 [3.0]                                1 [4.0]                               
      Ulcer                                            1 [3.0]      1 [3.0]      1 [4.0]                                            
      Epidermis, Hyperplasia                           1 [3.0]      1 [2.0]      1 [4.0]      1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/25/03    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 11:09:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                                  3 [2.3]      1 [2.0]      1 [3.0]                               
   Skeletal Muscle                                    (5)          (2)          (4)          (1)                                    
      Atrophy                                          1 [2.0]      1 [1.0]                                                         
      Inflammation, Chronic                            1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                      2 [3.5]                                                                      
      Cyst Epithelial Inclusion                        1                         1                                                  
      Hemorrhage                                                    2 [2.5]      1 [2.0]                                            
      Necrosis                                                      1 [3.0]                                                         
   Peripheral Nerve                                   (5)          (4)          (1)          (1)                                    
      Atrophy                                          3 [2.3]      2 [3.0]                                                         
      Inflammation, Chronic                                         1 [3.0]                                                         
   Spinal Cord                                        (4)          (4)          (2)          (1)                                    
      Atrophy                                                                    1 [2.0]                                            
      Hemorrhage                                                    1 [2.0]      1 [2.0]                                            
      Necrosis                                                      1 [4.0]      1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Edema                                            1 [2.0]      1 [2.0]      1 [3.0]                                            
      Emphysema                                                                  1 [3.0]                                            
      Foreign Body                                     1                                      2                                     
      Hemorrhage                                       6 [2.3]      7 [2.3]      6 [2.5]      7 [1.9]                               
      Hyperplasia, Lymphoid                            1 [2.0]                   4 [2.0]      1 [2.0]                               
      Infiltration Cellular, Polymorphonuclear                      1 [3.0]      1 [3.0]                                            
      Infiltration Cellular, Histiocyte                2 [2.5]      1 [3.0]      5 [2.8]                                            
      Inflammation, Chronic                            1 [2.0]                                1 [1.0]                               
      Thrombosis                                       1 [3.0]      2 [2.0]      1 [1.0]                                            
      Alveolar Epithelium, Hyperplasia                              2 [2.0]      1 [1.0]      2 [1.0]                               
      Alveolar Epithelium, Metaplasia, Bronchiolar                  2 [2.5]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96018-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/25/03    
Route: DOSED WATER                           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                 Time: 11:09:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/L       175 MG/L     350 MG/L     700 MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
   Eye                                                (48)         (50)         (50)         (50)                                   
      Developmental Malformation                       1                                      4                                     
      Hemorrhage                                                    2 [2.5]                                                         
      Inflammation, Chronic                                                                   2 [2.0]                               
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                               1 [2.0]      1 [3.0]      2 [2.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)                                   
      Amyloid Deposition                                                                      1 [4.0]                               
      Cyst                                                                                    1 [3.0]                               
      Hyperplasia, Lymphoid                            8 [2.1]      5 [2.2]      5 [2.0]      3 [2.0]                               
      Infarct                                          2 [1.5]      2 [1.0]      3 [1.0]      5 [2.0]                               
      Inflammation, Focal, Mixed Cell                                            1 [4.0]                                            
      Metaplasia, Osseous                              2 [1.5]                                1 [1.0]                               
      Nephropathy                                     16 [1.2]     14 [1.4]      7 [1.1]      8 [1.4]                               
      Renal Tubule, Accumulation, Hyaline Droplet      2 [2.5]      6 [3.2]      4 [2.3]      1 [3.0]                               
      Renal Tubule, Necrosis                           2 [1.5]                   2 [2.0]      1 [2.0]                               
      Renal Tubule, Pigmentation                       2 [2.0]                                1 [1.0]                               
      Renal Tubule, Regeneration                                                 1 [2.0]                                            
      Renal Tubule, Vacuolization Cytoplasmic                       1 [3.0]      1 [3.0]                                            
   Urinary Bladder                                    (50)         (49)         (48)         (50)                                   
      Edema                                                         2 [3.0]                   1 [3.0]                               
      Hyperplasia, Lymphoid                           11 [2.1]      7 [2.1]      4 [2.0]     10 [2.0]                               
      Inflammation, Chronic                                         1 [2.0]      1 [3.0]                                            
      Transitional Epithelium, Hyperplasia                          1 [3.0]      1 [3.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------