TDMS Study 93027-41 Pathology Tables
NTP Experiment-Test: 93027-41 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:43:30 13 WEEK SUBCHRONIC Facility: Battelle Columbus Laboratory Chemical CAS #: 94-75-7 Lock Date: 06/12/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 93027-41 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:43:30 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS MALE 0 PPM 17 PPM 83 PPM 250 PPM 750 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Survivors Terminal Sacrifice 10 10 10 10 10 10 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) (10) (10) Clear Cell Focus 1 (10%) Infiltration Cellular, Mononuclear Cell 1 (10%) 1 (10%) 1 (10%) Pancreas (10) (10) (10) (10) (10) (10) Inflammation, Chronic 1 (10%) Acinar Cell, Atrophy 1 (10%) Stomach, Glandular (10) (10) (10) (10) (10) (10) Mineralization 1 (10%) 8 (80%) 6 (60%) 6 (60%) 9 (90%) 9 (90%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) Cardiomyopathy 6 (60%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) (10) (10) Hypertrophy, Focal 1 (10%) 1 (10%) Zona Glomerulosa, Vacuolization Cytoplasmic 1 (10%) 1 (10%) 1 (10%) 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (10) (10) (9) (8) (9) (10) Inflammation, Chronic 8 (80%) 10 (100%) 7 (78%) 7 (88%) 6 (67%) 8 (80%) Prostate (10) Inflammation, Chronic 1 (10%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 93027-41 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:43:30 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS MALE 0 PPM 17 PPM 83 PPM 250 PPM 750 PPM 1250 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (10) Maxilla, Inflammation, Chronic 1 (10%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (1) Hemorrhage 1 (10%) 1 (100%) Infiltration Cellular, Histiocyte 1 (10%) Alveolus, Infiltration Cellular, Histiocyte 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) (10) (10) Nephropathy 6 (60%) 9 (90%) 9 (90%) 10 (100%) 7 (70%) 4 (40%) Corticomedullary Junction, Renal Tubule, Regeneration 1 (10%) 5 (50%) 5 (50%) 9 (90%) 10 (100%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 93027-41 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:43:30 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS MALE 2500 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 Early Deaths Survivors Terminal Sacrifice 10 Animals Examined Microscopically 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Stomach, Glandular (10) Mineralization 9 (90%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) Cardiomyopathy 3 (30%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) Zona Glomerulosa, Vacuolization Cytoplasmic 2 (20%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (10) Inflammation, Chronic 10 (100%) Testes (10) Atrophy 1 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 93027-41 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:43:30 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS MALE 2500 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) Hemorrhage 1 (10%) Inflammation 2 (20%) Inflammation, Chronic 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) Nephropathy 2 (20%) Corticomedullary Junction, Renal Tubule, Regeneration 10 (100%) a Number of animals examined microscopically at site and number of animals with lesion ------------------------------------------------------------ ---------- END OF REPORT ---------- 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