TDMS Study 93027-44 Pathology Tables
NTP Experiment-Test: 93027-44 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:45:35 13 WEEK SUBCHRONIC Facility: Battelle Columbus Laboratory Chemical CAS #: 94-75-7 Lock Date: 06/12/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 93027-44 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:45:35 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 12 PPM 28 PPM 83 PPM 250 PPM 700 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Survivors Terminal Sacrifice 10 10 10 10 10 10 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (9) Inflammation 1 (11%) Mineralization 1 (11%) Liver (10) (10) (10) (10) (10) (10) Mineralization 1 (10%) Necrosis, Focal 1 (10%) 1 (10%) 1 (10%) 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (10) (10) (10) (10) (10) (10) Inflammation, Chronic 1 (10%) Testes (10) (10) (10) (10) (10) (10) Interstitial Cell, Hyperplasia 1 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 93027-44 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:45:35 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 PPM 12 PPM 28 PPM 83 PPM 250 PPM 700 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) (10) (10) Nephropathy 1 (10%) 2 (20%) 2 (20%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 93027-44 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:45:35 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 1680 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 Early Deaths Survivors Terminal Sacrifice 10 Animals Examined Microscopically 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (10) Inflammation 1 (10%) Liver (10) Necrosis, Focal 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Parathyroid Gland (9) Cyst 2 (22%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 93027-44 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID) Date: 07/08/99 Route: DOSED FEED Time: 09:45:35 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 1680 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) Corticomedullary Junction, Renal Tubule, Regeneration 9 (90%) a Number of animals examined microscopically at site and number of animals with lesion ------------------------------------------------------------ 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