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TDMS Study 96020-01 Pathology Tables

NTP Experiment-Test: 96020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04
Route: GAVAGE                                                                                                     Time: 09:51:53

                                                            FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFBINARYMIX

       Lock Date:  03/27/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 002    10 NG / 10 UG
                               Include 003    100 NG /100 UG
                               Include 005    300 NG /300 UG
                               Include 007    1000 NG/1000 UG





























a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 96020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04  
Route: GAVAGE                                                                                                     Time: 09:51:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                     
                                                   0 UG         10 UG        100 UG       300 UG       1000 UG                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          98           86           98           98           98                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                22           19           24           19           20                        
    Natural Death                                      8           12            6           10            7                        
    Dosing Accident                                    1            1            1                         2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           21           22           24           24                        
                                                                                                                                    
  Animals Examined Microscopically                    53           53           53           53           53                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (53)         (53)         (53)         (52)         (49)                      
   Intestine Large, Rectum                            (53)         (53)         (53)         (53)         (50)                      
      Schwannoma Malignant, Metastatic, Vagina                      1 (2%)                    1 (2%)                                
   Intestine Large, Cecum                             (53)         (53)         (53)         (52)         (49)                      
   Intestine Small, Duodenum                          (53)         (53)         (52)         (52)         (50)                      
      Leiomyoma                                                                               2 (4%)                                
   Intestine Small, Jejunum                           (53)         (53)         (52)         (52)         (49)                      
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Small, Ileum                             (53)         (53)         (52)         (52)         (49)                      
   Liver                                              (53)         (53)         (52)         (52)         (51)                      
      Cholangiocarcinoma                                                                      4 (8%)       9 (18%)                  
      Cholangiocarcinoma, Multiple                                               1 (2%)       5 (10%)     21 (41%)                  
      Hemangioma                                       1 (2%)                                                                       
      Hepatocellular Carcinoma                                                                             2 (4%)                   
      Hepatocellular Adenoma                                                     3 (6%)       5 (10%)     11 (22%)                  
      Hepatocellular Adenoma, Multiple                                                                    16 (31%)                  
      Hepatocholangioma                                                                       2 (4%)       5 (10%)                  
      Hepatocholangioma, Multiple                                                                          1 (2%)                   
   Mesentery                                          (47)         (47)         (46)         (47)         (42)                      
      Nephroblastoma, Metastatic, Kidney                            1 (2%)                                                          
   Oral Mucosa                                        (12)         (11)         (25)         (30)         (36)                      
      Gingival, Squamous Cell Carcinoma                                          2 (8%)       5 (17%)      8 (22%)                  
      Gingival, Squamous Cell Carcinoma, Multiple                                                          1 (3%)                   
   Pancreas                                           (53)         (53)         (52)         (52)         (50)                      
      Acinus, Adenoma                                               1 (2%)       1 (2%)       3 (6%)       1 (2%)                   
      Acinus, Carcinoma                                                                       1 (2%)       1 (2%)                   
   Salivary Glands                                    (53)         (51)         (52)         (50)         (52)                      
   Stomach, Forestomach                               (53)         (53)         (52)         (52)         (51)                      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04  
Route: GAVAGE                                                                                                     Time: 09:51:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                     
                                                   0 UG         10 UG        100 UG       300 UG       1000 UG                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Stomach, Glandular                                 (53)         (53)         (52)         (52)         (51)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (53)         (53)         (52)         (53)         (52)                      
   Heart                                              (53)         (52)         (52)         (53)         (52)                      
      Fibrosarcoma, Metastatic, Lung                                                          1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                       1 (2%)                                                                       
      Schwannoma Malignant                                          1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (53)         (53)         (52)         (52)         (51)                      
      Adenoma                                                                                 1 (2%)       1 (2%)                   
   Adrenal Medulla                                    (52)         (53)         (52)         (52)         (51)                      
      Pheochromocytoma Benign                          2 (4%)       1 (2%)       4 (8%)       1 (2%)                                
      Bilateral, Pheochromocytoma Benign               1 (2%)                                              1 (2%)                   
   Islets, Pancreatic                                 (53)         (53)         (52)         (52)         (50)                      
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Parathyroid Gland                                  (45)         (47)         (46)         (47)         (46)                      
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (53)         (53)         (53)         (52)         (52)                      
      Carcinoma                                        1 (2%)                                                                       
      Pars Distalis, Adenoma                          22 (42%)     21 (40%)     17 (32%)     17 (33%)      1 (2%)                   
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
      Pars Intermedia, Adenoma                                                   2 (4%)                                             
   Thyroid Gland                                      (53)         (53)         (51)         (52)         (52)                      
      Bilateral, C-Cell, Adenoma                       2 (4%)       4 (8%)       4 (8%)       3 (6%)                                
      C-Cell, Adenoma                                  8 (15%)     10 (19%)     12 (24%)     12 (23%)      7 (13%)                  
      C-Cell, Carcinoma                                4 (8%)                    1 (2%)       1 (2%)                                
      Follicular Cell, Adenoma                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04  
Route: GAVAGE                                                                                                     Time: 09:51:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                     
                                                   0 UG         10 UG        100 UG       300 UG       1000 UG                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (53)         (53)         (53)         (53)         (50)                      
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                     1 (2%)                                                          
   Ovary                                              (53)         (53)         (52)         (52)         (49)                      
      Granulosa Cell Tumor Malignant                   1 (2%)                                 1 (2%)                                
      Granulosa Cell Tumor Benign                                                             1 (2%)                                
   Uterus                                             (53)         (53)         (53)         (52)         (50)                      
      Adenoma                                                                                              1 (2%)                   
      Carcinoma                                                     1 (2%)                                                          
      Fibrosarcoma                                                                            1 (2%)                                
      Polyp Stromal                                    5 (9%)       7 (13%)      5 (9%)       6 (12%)      3 (6%)                   
      Polyp Stromal, Multiple                          3 (6%)                    2 (4%)                                             
      Sarcoma                                                                    1 (2%)                                             
      Sarcoma Stromal                                                            1 (2%)                                             
      Schwannoma Malignant                                                                    2 (4%)                                
      Schwannoma Malignant, Metastatic, Vagina                                                1 (2%)                                
      Squamous Cell Carcinoma                          1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Cervix, Granular Cell Tumor Benign                                                      1 (2%)                                
      Cervix, Squamous Cell Carcinoma                                                         2 (4%)                                
   Vagina                                             (1)          (1)          (1)          (1)                                    
      Schwannoma Malignant                                          1 (100%)                  1 (100%)                              
      Squamous Cell Carcinoma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (53)         (53)         (53)         (53)                      
   Lymph Node                                         (4)          (7)          (2)          (7)          (14)                      
      Nephroblastoma, Metastatic, Kidney                            1 (14%)                                                         
      Pancreatic, Nephroblastoma, Metastatic,                                                                                       
          Kidney                                                    1 (14%)                                                         
   Lymph Node, Mandibular                             (53)         (51)         (52)         (50)         (51)                      
   Lymph Node, Mesenteric                             (53)         (53)         (52)         (52)         (49)                      
   Spleen                                             (53)         (53)         (52)         (52)         (50)                      
   Thymus                                             (53)         (50)         (48)         (50)         (51)                      
      Squamous Cell Carcinoma, Metastatic, Lung                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04  
Route: GAVAGE                                                                                                     Time: 09:51:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                     
                                                   0 UG         10 UG        100 UG       300 UG       1000 UG                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (53)         (52)         (53)         (52)                      
      Adenoma                                          2 (4%)       1 (2%)                                                          
      Carcinoma                                        6 (11%)      4 (8%)       2 (4%)       1 (2%)                                
      Carcinoma, Multiple                              2 (4%)                    1 (2%)       1 (2%)                                
      Fibroadenoma                                    27 (51%)     22 (42%)     25 (48%)     25 (47%)     11 (21%)                  
      Fibroadenoma, Multiple                          13 (25%)     17 (32%)     15 (29%)      9 (17%)      1 (2%)                   
   Skin                                               (53)         (53)         (53)         (53)         (53)                      
      Basal Cell Carcinoma                                          2 (4%)                                 1 (2%)                   
      Fibroma                                          2 (4%)       1 (2%)       3 (6%)       1 (2%)                                
      Fibrosarcoma                                                  1 (2%)                                                          
      Fibrous Histiocytoma                                                       1 (2%)                                             
      Keratoacanthoma                                                            1 (2%)                                             
      Lipoma                                                                                  1 (2%)       1 (2%)                   
      Liposarcoma                                                   1 (2%)                                                          
      Sarcoma                                                       1 (2%)                                 1 (2%)                   
      Schwannoma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (53)         (53)         (53)         (53)         (53)                      
   Skeletal Muscle                                    (1)          (1)                       (1)          (1)                       
      Fibrosarcoma, Metastatic, Lung                                                          1 (100%)                              
      Fibrous Histiocytoma                             1 (100%)                                                                     
      Hemangiosarcoma                                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (53)         (53)         (52)         (52)                      
      Astrocytoma Malignant                                         1 (2%)                                                          
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)       1 (2%)                                                          
      Granular Cell Tumor Malignant                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (53)         (53)         (52)         (53)         (52)                      
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
      Cystic Keratinizing Epithelioma                                                         1 (2%)       3 (6%)                   
      Cystic Keratinizing Epithelioma, Multiple                                                            8 (15%)                  
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04  
Route: GAVAGE                                                                                                     Time: 09:51:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                     
                                                   0 UG         10 UG        100 UG       300 UG       1000 UG                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Muscle                                       1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
      Squamous Cell Carcinoma                                                                 1 (2%)       1 (2%)                   
      Mediastinum, Fibrosarcoma                                                               1 (2%)                                
   Nose                                               (53)         (53)         (53)         (53)         (53)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (53)         (53)         (53)         (52)         (52)                      
   Harderian Gland                                    (53)         (53)         (53)         (52)         (52)                      
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                              1 (2%)       3 (6%)                   
   Zymbal's Gland                                                  (1)                       (1)                                    
      Adenoma                                                                                 1 (100%)                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (53)         (52)         (52)         (51)                      
      Nephroblastoma                                                1 (2%)                    1 (2%)       1 (2%)                   
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Ureter                                             (1)          (1)                       (1)          (1)                       
   Urinary Bladder                                    (53)         (53)         (53)         (52)         (50)                      
      Nephroblastoma, Metastatic, Kidney                            1 (2%)                                                          
      Papilloma                                        1 (2%)                                              1 (2%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(53)        *(53)        *(53)        *(53)        *(53)                      
      Lymphoma Malignant                                            1 (2%)       2 (4%)       2 (4%)       2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04  
Route: GAVAGE                                                                                                     Time: 09:51:53  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SPRAGUE-DAWLEY RATS FEMALE                0 NG /       10 NG /      100 NG /     300 NG /     1000 NG/                     
                                                   0 UG         10 UG        100 UG       300 UG       1000 UG                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            51          49          50          50          46                           
     Total Primary Neoplasms                          110         106         110         126         121                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          43          48          46          36                           
     Total Benign Neoplasms                            92          85          96          93          73                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          18          14          23          37                           
     Total Malignant Neoplasms                         18          21          14          33          48                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           5                       3           3                           
     Total Metastatic Neoplasm                          4           8                       6           3                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
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