National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14641

TDMS Study 96020-01 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   DATE: 03/03/04       
EXPERIMENT: 96020 TEST: 01                                                                                     TIME: 09:55:48       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96020       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFBINARYMIX    
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                              FINAL #1                                                              
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25018 Dosing Accident                                                                        
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 NG /  0 UG                                                                  
                                       INCLUDE 002    10 NG / 10 UG                                                                 
                                       INCLUDE 003    100 NG /100 UG                                                                
                                       INCLUDE 005    300 NG /300 UG                                                                
                                       INCLUDE 007    1000 NG/1000 UG                                                               
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   DATE: 03/03/04       
EXPERIMENT: 96020 TEST: 01                                                                                     TIME: 09:55:48       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96020       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFBINARYMIX    
Rats(SPRAGUE-DAWLEY)                                                                                                                
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Brain                                                                              
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Parathyroid Gland                                                                  
                                                 Pituitary Gland                                                                    
                                                 Thyroid Gland                                                                      
                                                 Urinary Bladder                                                                    
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   DATE: 03/03/04       
EXPERIMENT: 96020 TEST: 01                                                                                     TIME: 09:55:48       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96020       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFBINARYMIX    
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF    TEF EVALUATION (BINARY MIXTURE; PCB 126                                                                       
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Liver                                  Cholangiocarcinoma                                                                           
                                       Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma                                                                     
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
                                       Hepatocholangioma                                                                            
Lung                                   Cystic Keratinizing Epithelioma                                                              
Mammary Gland                          Carcinoma                                                                                    
                                       Carcinoma or Adenoma                                                                         
                                       Fibroadenoma                                                                                 
                                       Fibroma, Fibroadenoma or Adenoma                                                             
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                 
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                          
                                       Squamous Cell Carcinoma                                                                      
                                       Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                    
Oral Mucosa                            Squamous Cell Carcinoma                                                                      
Pituitary Gland: Pars Distalis or Unspecified Site                                                                                  
                                       Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Thyroid Gland: C-Cell                  Adenoma                                                                                      
                                       Carcinoma                                                                                    
                                       Carcinoma or Adenoma                                                                         
Uterus                                 Sarcoma Stromal or Polyp Stromal                                                             
All Organs                             Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
===============================================================                                                                     
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 1       
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)        -     TEF EVALUATION (BINARY MIXTURE; PCB 126                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/52 (6%)        1/53 (2%)        4/52 (8%)        1/52 (2%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        3/37.43          1/37.40          4/39.19          1/37.39          1/37.18                          | 
|POLY-3 PERCENT (g) |        8.0%             2.7%             10.2%            2.7%             2.7%                             | 
|TERMINAL (d)       |        2/21 (10%)       1/21 (5%)        2/22 (9%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        664              729 (T)          636              729 (T)          314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.239N         P=0.311N         P=0.511          P=0.279N         P=0.302N                         | 
|POLY 3             |        P=0.255N         P=0.304N         P=0.525          P=0.304N         P=0.306N                         | 
|POLY 1.5           |        P=0.261N         P=0.305N         P=0.515          P=0.306N         P=0.312N                         | 
|POLY 6             |        P=0.250N         P=0.301N         P=0.535          P=0.300N         P=0.299N                         | 
|LOGISTIC REGRESSION|        P=0.269N         P=0.295N         P=0.533          P=0.291N         P=0.309N                         | 
|COCH-ARM / FISHERS |        P=0.266N         P=0.302N         P=0.500          P=0.309N         P=0.316N                         | 
|ORDER RESTRICTED   |        P=0.262N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Duodenum                                                                                                        | 
|     Leiomyoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/53 (0%)        2/53 (4%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/39.03          2/37.47          0/36.47                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.3%             0.0%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              710              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.737          (e)              (e)              P=0.263          (e)                              | 
|POLY 3             |        P=0.706          (e)              (e)              P=0.232          (e)                              | 
|POLY 1.5           |        P=0.706          (e)              (e)              P=0.232          (e)                              | 
|POLY 6             |        P=0.708          (e)              (e)              P=0.234          (e)                              | 
|LOGISTIC REGRESSION|        P=0.724          (e)              (e)              P=0.240          (e)                              | 
|COCH-ARM / FISHERS |        P=0.724          (e)              (e)              P=0.248          (e)                              | 
|ORDER RESTRICTED   |        P=0.213          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 2       
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Leiomyoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/53 (0%)        2/53 (4%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/39.03          2/37.47          0/36.47                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.3%             0.0%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              710              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.737          (e)              (e)              P=0.263          (e)                              | 
|POLY 3             |        P=0.706          (e)              (e)              P=0.232          (e)                              | 
|POLY 1.5           |        P=0.706          (e)              (e)              P=0.232          (e)                              | 
|POLY 6             |        P=0.708          (e)              (e)              P=0.234          (e)                              | 
|LOGISTIC REGRESSION|        P=0.724          (e)              (e)              P=0.240          (e)                              | 
|COCH-ARM / FISHERS |        P=0.724          (e)              (e)              P=0.248          (e)                              | 
|ORDER RESTRICTED   |        P=0.213          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiocarcinoma                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        1/52 (2%)        9/52 (17%)       30/51 (59%)                      | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          1/38.82          9/38.00          30/39.75                         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.6%             23.7%            75.5%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        7/24 (29%)       20/24 (83%)                      | 
|FIRST INCIDENCE    |        ---              ---              729 (T)          603              479                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.500          P=0.003 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.503          P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.501          P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.506          P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.500          P=0.002 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.495          P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 3       
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        3/52 (6%)        5/52 (10%)       27/51 (53%)                      | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          3/39.16          5/37.57          27/39.88                         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.7%             13.3%            67.7%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        4/24 (17%)       18/24 (75%)                      | 
|FIRST INCIDENCE    |        ---              ---              654              684              479                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.134          P=0.040 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.122          P=0.028 *        P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.120          P=0.028 *        P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.125          P=0.028 *        P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.124          P=0.032 *        P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.118          P=0.027 *        P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/52 (0%)        0/52 (0%)        2/51 (4%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/38.82          0/37.39          2/36.26                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             5.5%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        2/24 (8%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.025 *        (e)              (e)              (e)              P=0.257                          | 
|POLY 3             |        P=0.017 *        (e)              (e)              (e)              P=0.225                          | 
|POLY 1.5           |        P=0.017 *        (e)              (e)              (e)              P=0.224                          | 
|POLY 6             |        P=0.017 *        (e)              (e)              (e)              P=0.227                          | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.257                          | 
|COCH-ARM / FISHERS |        P=0.018 *        (e)              (e)              (e)              P=0.238                          | 
|ORDER RESTRICTED   |        P=0.014 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 4       
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        3/52 (6%)        5/52 (10%)       27/51 (53%)                      | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          3/39.16          5/37.57          27/39.88                         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.7%             13.3%            67.7%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        4/24 (17%)       18/24 (75%)                      | 
|FIRST INCIDENCE    |        ---              ---              654              684              479                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.134          P=0.040 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.122          P=0.028 *        P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.120          P=0.028 *        P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.125          P=0.028 *        P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.124          P=0.032 *        P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.118          P=0.027 *        P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        3/52 (6%)        5/52 (10%)       27/51 (53%)                      | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          3/39.16          5/37.57          27/39.88                         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.7%             13.3%            67.7%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        4/24 (17%)       18/24 (75%)                      | 
|FIRST INCIDENCE    |        ---              ---              654              684              479                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.134          P=0.040 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.122          P=0.028 *        P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.120          P=0.028 *        P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.125          P=0.028 *        P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.124          P=0.032 *        P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.118          P=0.027 *        P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 5       
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocholangioma                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/52 (0%)        2/52 (4%)        6/51 (12%)                       | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/38.82          2/37.39          6/36.26                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.4%             16.6%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        2/24 (8%)        6/24 (25%)                       | 
|FIRST INCIDENCE    |        ---              ---              ---              729 (T)          729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.257          P=0.020 *                        | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.232          P=0.012 *                        | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.231          P=0.012 *                        | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.233          P=0.012 *                        | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.257          P=0.020 *                        | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.243          P=0.012 *                        | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Cystic Keratinizing Epithelioma                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/52 (0%)        1/53 (2%)        11/52 (21%)                      | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/38.82          1/37.40          11/37.46                         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             2.7%             29.4%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        1/24 (4%)        7/24 (29%)                       | 
|FIRST INCIDENCE    |        ---              ---              ---              729 (T)          606                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.517          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.496          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.495          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.498          P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P=0.517          P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.500          P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 6       
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        1/53 (2%)        0/53 (0%)        0/53 (0%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        2/38.18          1/37.40          0/39.03          0/37.40          0/36.47                          | 
|POLY-3 PERCENT (g) |        5.2%             2.7%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        2/22 (9%)        1/21 (5%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        729 (T)          729 (T)          ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.208N         P=0.516N         P=0.237N         P=0.218N         P=0.218N                         | 
|POLY 3             |        P=0.230N         P=0.507N         P=0.232N         P=0.241N         P=0.247N                         | 
|POLY 1.5           |        P=0.229N         P=0.507N         P=0.234N         P=0.242N         P=0.248N                         | 
|POLY 6             |        P=0.230N         P=0.505N         P=0.229N         P=0.238N         P=0.244N                         | 
|LOGISTIC REGRESSION|        P=0.208N         P=0.516N         (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.226N         P=0.500N         P=0.248N         P=0.248N         P=0.248N                         | 
|ORDER RESTRICTED   |        P=0.052N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/53 (15%)       4/53 (8%)        3/53 (6%)        2/53 (4%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        8/39.17          4/38.30          3/39.78          2/38.16          0/36.47                          | 
|POLY-3 PERCENT (g) |        20.4%            10.4%            7.5%             5.2%             0.0%                             | 
|TERMINAL (d)       |        6/22 (27%)       3/21 (14%)       2/22 (9%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        449              337              461              451              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007N**       P=0.196N         P=0.096N         P=0.039N*        P=0.004N**                       | 
|POLY 3             |        P=0.010N*        P=0.182N         P=0.089N         P=0.046N*        P=0.005N**                       | 
|POLY 1.5           |        P=0.010N*        P=0.184N         P=0.093N         P=0.048N*        P=0.005N**                       | 
|POLY 6             |        P=0.010N*        P=0.179N         P=0.086N         P=0.044N*        P=0.004N**                       | 
|LOGISTIC REGRESSION|        P=0.010N*        P=0.186N         P=0.095N         P=0.051N         P=0.006N**                       | 
|COCH-ARM / FISHERS |        P=0.010N*        P=0.179N         P=0.101N         P=0.046N*        P=0.003N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 7       
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/53 (19%)      5/53 (9%)        3/53 (6%)        2/53 (4%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        10/39.17         5/38.30          3/39.78          2/38.16          0/36.47                          | 
|POLY-3 PERCENT (g) |        25.5%            13.1%            7.5%             5.2%             0.0%                             | 
|TERMINAL (d)       |        8/22 (36%)       4/21 (19%)       2/22 (9%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        449              337              461              451              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002N**       P=0.143N         P=0.033N*        P=0.011N*        P<0.001N**                       | 
|POLY 3             |        P=0.003N**       P=0.132N         P=0.029N*        P=0.013N*        P<0.001N**                       | 
|POLY 1.5           |        P=0.003N**       P=0.135N         P=0.031N*        P=0.014N*        P<0.001N**                       | 
|POLY 6             |        P=0.003N**       P=0.127N         P=0.026N*        P=0.012N*        P<0.001N**                       | 
|LOGISTIC REGRESSION|        P=0.004N**       P=0.138N         P=0.033N*        P=0.016N*        P<0.001N**                       | 
|COCH-ARM / FISHERS |        P=0.004N**       P=0.132N         P=0.036N*        P=0.014N*        P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        40/53 (75%)      39/53 (74%)      40/53 (75%)      34/53 (64%)      12/53 (23%)                      | 
|POLY-3 RATE (b)    |        40/48.11         39/45.83         40/47.48         34/46.23         12/38.26                         | 
|POLY-3 PERCENT (g) |        83.1%            85.1%            84.2%            73.5%            31.4%                            | 
|TERMINAL (d)       |        16/22 (73%)      17/21 (81%)      17/22 (77%)      15/24 (63%)      7/24 (29%)                       | 
|FIRST INCIDENCE    |        345              296              254              254              479                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.553          P=0.522N         P=0.209N         P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.510          P=0.555          P=0.178N         P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.566          P=0.584          P=0.166N         P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.456          P=0.508          P=0.204N         P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.570N         P=0.564N         P=0.165N         P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.500N         P=0.589N         P=0.145N         P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 8       
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        40/53 (75%)      39/53 (74%)      40/53 (75%)      34/53 (64%)      12/53 (23%)                      | 
|POLY-3 RATE (b)    |        40/48.11         39/45.83         40/47.48         34/46.23         12/38.26                         | 
|POLY-3 PERCENT (g) |        83.1%            85.1%            84.2%            73.5%            31.4%                            | 
|TERMINAL (d)       |        16/22 (73%)      17/21 (81%)      17/22 (77%)      15/24 (63%)      7/24 (29%)                       | 
|FIRST INCIDENCE    |        345              296              254              254              479                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.553          P=0.522N         P=0.209N         P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.510          P=0.555          P=0.178N         P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.566          P=0.584          P=0.166N         P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.456          P=0.508          P=0.204N         P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.570N         P=0.564N         P=0.165N         P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.500N         P=0.589N         P=0.145N         P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        42/53 (79%)      41/53 (77%)      42/53 (79%)      35/53 (66%)      12/53 (23%)                      | 
|POLY-3 RATE (b)    |        42/48.88         41/46.73         42/48.23         35/47.00         12/38.26                         | 
|POLY-3 PERCENT (g) |        85.9%            87.7%            87.1%            74.5%            31.4%                            | 
|TERMINAL (d)       |        17/22 (77%)      18/21 (86%)      18/22 (82%)      15/24 (63%)      7/24 (29%)                       | 
|FIRST INCIDENCE    |        345              296              254              254              479                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.547          P=0.519N         P=0.174N         P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.518          P=0.555          P=0.114N         P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.581          P=0.587          P=0.106N         P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.449          P=0.504          P=0.132N         P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.569N         P=0.571N         P=0.109N         P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.500N         P=0.594N         P=0.095N         P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 9       
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        2/53 (4%)        5/53 (9%)        9/53 (17%)                       | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          2/40.06          5/38.73          9/39.63                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             5.0%             12.9%            22.7%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              491              479              563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.242          P=0.043 *        P=0.003 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.247          P=0.031 *        P=0.002 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.243          P=0.030 *        P=0.002 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.252          P=0.033 *        P=0.003 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.232          P=0.032 *        P=0.002 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.248          P=0.028 *        P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        2/53 (4%)        5/53 (9%)        9/53 (17%)                       | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          2/40.06          5/38.73          9/39.63                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             5.0%             12.9%            22.7%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              491              479              563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.242          P=0.043 *        P=0.003 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.247          P=0.031 *        P=0.002 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.243          P=0.030 *        P=0.002 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.252          P=0.033 *        P=0.003 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.232          P=0.032 *        P=0.002 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.248          P=0.028 *        P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 10      
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa                                                                                                                      | 
|     Squamous Cell Carcinoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        2/53 (4%)        5/53 (9%)        9/53 (17%)                       | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          2/40.06          5/38.73          9/39.63                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             5.0%             12.9%            22.7%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              491              479              563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.242          P=0.043 *        P=0.003 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.247          P=0.031 *        P=0.002 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.243          P=0.030 *        P=0.002 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.252          P=0.033 *        P=0.003 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.232          P=0.032 *        P=0.002 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.248          P=0.028 *        P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Granulosa Cell Tumor: Benign, Malignant, NOS                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        0/53 (0%)        0/52 (0%)        2/52 (4%)        0/49 (0%)                        | 
|POLY-3 RATE (b)    |        1/38.18          0/37.40          0/38.82          2/37.39          0/35.41                          | 
|POLY-3 PERCENT (g) |        2.6%             0.0%             0.0%             5.4%             0.0%                             | 
|TERMINAL (d)       |        1/22 (5%)        0/21 (0%)        0/22 (0%)        2/24 (8%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        729 (T)          ---              ---              729 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.535N         P=0.509N         P=0.500N         P=0.531          P=0.483N                         | 
|POLY 3             |        P=0.585N         P=0.504N         P=0.497N         P=0.493          P=0.515N                         | 
|POLY 1.5           |        P=0.588N         P=0.504N         P=0.499N         P=0.491          P=0.518N                         | 
|POLY 6             |        P=0.579N         P=0.503N         P=0.494N         P=0.496          P=0.510N                         | 
|LOGISTIC REGRESSION|        P=0.535N         (e)              (e)              P=0.531          (e)                              | 
|COCH-ARM / FISHERS |        P=0.585N         P=0.500N         P=0.505N         P=0.493          P=0.520N                         | 
|ORDER RESTRICTED   |        P=0.325N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 11      
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/53 (2%)        1/52 (2%)        3/52 (6%)        1/50 (2%)                        | 
|POLY-3 RATE (b)    |        0/38.18          1/37.52          1/38.82          3/37.39          1/36.09                          | 
|POLY-3 PERCENT (g) |        0.0%             2.7%             2.6%             8.0%             2.8%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        3/24 (13%)       0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              698              729 (T)          729 (T)          654                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.536          P=0.492          P=0.500          P=0.135          P=0.468                          | 
|POLY 3             |        P=0.494          P=0.496          P=0.503          P=0.114          P=0.489                          | 
|POLY 1.5           |        P=0.486          P=0.496          P=0.501          P=0.114          P=0.485                          | 
|POLY 6             |        P=0.506          P=0.499          P=0.506          P=0.115          P=0.494                          | 
|LOGISTIC REGRESSION|        P=0.500          P=0.497          P=0.500          P=0.135          P=0.486                          | 
|COCH-ARM / FISHERS |        P=0.494          P=0.500          P=0.495          P=0.118          P=0.485                          | 
|ORDER RESTRICTED   |        P=0.150          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/53 (2%)        1/52 (2%)        4/52 (8%)        2/50 (4%)                        | 
|POLY-3 RATE (b)    |        0/38.18          1/37.52          1/38.82          4/37.39          2/36.09                          | 
|POLY-3 PERCENT (g) |        0.0%             2.7%             2.6%             10.7%            5.5%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        4/24 (17%)       1/24 (4%)                        | 
|FIRST INCIDENCE    |        ---              698              729 (T)          729 (T)          654                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.277          P=0.492          P=0.500          P=0.072          P=0.231                          | 
|POLY 3             |        P=0.226          P=0.496          P=0.503          P=0.056          P=0.224                          | 
|POLY 1.5           |        P=0.221          P=0.496          P=0.501          P=0.057          P=0.221                          | 
|POLY 6             |        P=0.236          P=0.499          P=0.506          P=0.057          P=0.229                          | 
|LOGISTIC REGRESSION|        P=0.236          P=0.497          P=0.500          P=0.072          P=0.224                          | 
|COCH-ARM / FISHERS |        P=0.229          P=0.500          P=0.495          P=0.057          P=0.233                          | 
|ORDER RESTRICTED   |        P=0.060          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 12      
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        22/53 (42%)      21/53 (40%)      17/53 (32%)      17/52 (33%)      1/52 (2%)                        | 
|POLY-3 RATE (b)    |        22/41.64         21/40.38         17/41.12         17/38.83         1/36.33                          | 
|POLY-3 PERCENT (g) |        52.8%            52.0%            41.3%            43.8%            2.8%                             | 
|TERMINAL (d)       |        13/22 (59%)      10/21 (48%)      11/22 (50%)      12/24 (50%)      0/24 (0%)                        | 
|FIRST INCIDENCE    |        418              563              499              506              714                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.541N         P=0.212N         P=0.168N         P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.560N         P=0.195N         P=0.271N         P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.558N         P=0.199N         P=0.268N         P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.528N         P=0.195N         P=0.268N         P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.536N         P=0.175N         P=0.243N         P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.500N         P=0.210N         P=0.232N         P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        23/53 (43%)      22/53 (42%)      17/53 (32%)      17/52 (33%)      1/52 (2%)                        | 
|POLY-3 RATE (b)    |        23/41.70         22/40.38         17/41.12         17/38.83         1/36.33                          | 
|POLY-3 PERCENT (g) |        55.2%            54.5%            41.3%            43.8%            2.8%                             | 
|TERMINAL (d)       |        13/22 (59%)      11/21 (52%)      11/22 (50%)      12/24 (50%)      0/24 (0%)                        | 
|FIRST INCIDENCE    |        418              563              499              506              714                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.543N         P=0.162N         P=0.126N         P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.567N         P=0.139N         P=0.203N         P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.562N         P=0.145N         P=0.203N         P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.536N         P=0.138N         P=0.199N         P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.537N         P=0.126N         P=0.182N         P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.500N         P=0.158N         P=0.177N         P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 13      
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        2/53 (4%)        0/52 (0%)        0/52 (0%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          2/39.87          0/36.79          0/36.27                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             5.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              461              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.479N         (e)              P=0.262          (e)              (e)                              | 
|POLY 3             |        P=0.489N         (e)              P=0.246          (e)              (e)                              | 
|POLY 1.5           |        P=0.493N         (e)              P=0.243          (e)              (e)                              | 
|POLY 6             |        P=0.485N         (e)              P=0.250          (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.484N         (e)              P=0.234          (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.494N         (e)              P=0.248          (e)              (e)                              | 
|ORDER RESTRICTED   |        P=0.398          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/53 (4%)        0/53 (0%)        0/53 (0%)        1/53 (2%)                        | 
|POLY-3 RATE (b)    |        0/38.18          2/37.83          0/39.03          0/37.40          1/37.45                          | 
|POLY-3 PERCENT (g) |        0.0%             5.3%             0.0%             0.0%             2.7%                             | 
|TERMINAL (d)       |        0/22 (0%)        1/21 (5%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              603              ---              ---              181                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.604          P=0.235          (e)              (e)              P=0.492                          | 
|POLY 3             |        P=0.599          P=0.234          (e)              (e)              P=0.496                          | 
|POLY 1.5           |        P=0.598          P=0.233          (e)              (e)              P=0.495                          | 
|POLY 6             |        P=0.603          P=0.237          (e)              (e)              P=0.499                          | 
|LOGISTIC REGRESSION|        P=0.651          P=0.234          (e)              (e)              P=0.694                          | 
|COCH-ARM / FISHERS |        P=0.607          P=0.248          (e)              (e)              P=0.500                          | 
|ORDER RESTRICTED   |        P=0.303          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 14      
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/53 (4%)        1/53 (2%)        0/53 (0%)        1/53 (2%)                        | 
|POLY-3 RATE (b)    |        0/38.18          2/37.83          1/39.86          0/37.40          1/37.45                          | 
|POLY-3 PERCENT (g) |        0.0%             5.3%             2.5%             0.0%             2.7%                             | 
|TERMINAL (d)       |        0/22 (0%)        1/21 (5%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              603              407              ---              181                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.679          P=0.235          P=0.504          (e)              P=0.492                          | 
|POLY 3             |        P=0.677          P=0.234          P=0.509          (e)              P=0.496                          | 
|POLY 1.5           |        P=0.676          P=0.233          P=0.505          (e)              P=0.495                          | 
|POLY 6             |        P=0.680          P=0.237          P=0.511          (e)              P=0.499                          | 
|LOGISTIC REGRESSION|        P=0.607N         P=0.234          P=0.485          (e)              P=0.694                          | 
|COCH-ARM / FISHERS |        P=0.677N         P=0.248          P=0.500          (e)              P=0.500                          | 
|ORDER RESTRICTED   |        P=0.365          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        1/53 (2%)        3/53 (6%)        1/53 (2%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        2/38.47          1/37.40          3/39.33          1/37.66          0/36.47                          | 
|POLY-3 PERCENT (g) |        5.2%             2.7%             7.6%             2.7%             0.0%                             | 
|TERMINAL (d)       |        0/22 (0%)        1/21 (5%)        1/22 (5%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        664              729 (T)          664              659              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.153N         P=0.513N         P=0.507          P=0.509N         P=0.250N                         | 
|POLY 3             |        P=0.157N         P=0.510N         P=0.510          P=0.507N         P=0.248N                         | 
|POLY 1.5           |        P=0.158N         P=0.509N         P=0.506          P=0.508N         P=0.248N                         | 
|POLY 6             |        P=0.156N         P=0.510N         P=0.514          P=0.504N         P=0.248N                         | 
|LOGISTIC REGRESSION|        P=0.156N         P=0.505N         P=0.512          P=0.506N         P=0.246N                         | 
|COCH-ARM / FISHERS |        P=0.150N         P=0.500N         P=0.500          P=0.500N         P=0.248N                         | 
|ORDER RESTRICTED   |        P=0.196N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 15      
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        3/53 (6%)        4/53 (8%)        1/53 (2%)        1/53 (2%)                        | 
|POLY-3 RATE (b)    |        2/38.47          3/38.36          4/39.33          1/37.66          1/37.44                          | 
|POLY-3 PERCENT (g) |        5.2%             7.8%             10.2%            2.7%             2.7%                             | 
|TERMINAL (d)       |        0/22 (0%)        1/21 (5%)        2/22 (9%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        664              407              664              659              206                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.204N         P=0.483          P=0.346          P=0.509N         P=0.517N                         | 
|POLY 3             |        P=0.208N         P=0.499          P=0.346          P=0.507N         P=0.509N                         | 
|POLY 1.5           |        P=0.209N         P=0.496          P=0.343          P=0.508N         P=0.511N                         | 
|POLY 6             |        P=0.206N         P=0.504          P=0.348          P=0.504N         P=0.508N                         | 
|LOGISTIC REGRESSION|        P=0.203N         P=0.496          P=0.349          P=0.506N         P=0.458N                         | 
|COCH-ARM / FISHERS |        P=0.201N         P=0.500          P=0.339          P=0.500N         P=0.500N                         | 
|ORDER RESTRICTED   |        P=0.294N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/53 (4%)        1/53 (2%)        0/53 (0%)        1/53 (2%)                        | 
|POLY-3 RATE (b)    |        0/38.18          2/38.36          1/39.03          0/37.40          1/37.44                          | 
|POLY-3 PERCENT (g) |        0.0%             5.2%             2.6%             0.0%             2.7%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              407              729 (T)          ---              206                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.671N         P=0.231          P=0.500          (e)              P=0.488                          | 
|POLY 3             |        P=0.679          P=0.237          P=0.504          (e)              P=0.496                          | 
|POLY 1.5           |        P=0.677          P=0.235          P=0.503          (e)              P=0.494                          | 
|POLY 6             |        P=0.679N         P=0.241          P=0.506          (e)              P=0.499                          | 
|LOGISTIC REGRESSION|        P=0.625N         P=0.247          P=0.500          (e)              P=0.678                          | 
|COCH-ARM / FISHERS |        P=0.677N         P=0.248          P=0.500          (e)              P=0.500                          | 
|ORDER RESTRICTED   |        P=0.365          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 16      
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/53 (19%)      14/53 (26%)      16/51 (31%)      15/52 (29%)      7/52 (13%)                       | 
|POLY-3 RATE (b)    |        10/39.40         14/39.56         16/39.94         15/38.93         7/37.39                          | 
|POLY-3 PERCENT (g) |        25.4%            35.4%            40.1%            38.5%            18.7%                            | 
|TERMINAL (d)       |        7/22 (32%)       8/21 (38%)       11/22 (50%)      10/24 (42%)      4/24 (17%)                       | 
|FIRST INCIDENCE    |        426              499              603              499              485                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.047N*        P=0.224          P=0.129          P=0.225          P=0.268N                         | 
|POLY 3             |        P=0.077N         P=0.231          P=0.118          P=0.151          P=0.333N                         | 
|POLY 1.5           |        P=0.083N         P=0.224          P=0.115          P=0.146          P=0.343N                         | 
|POLY 6             |        P=0.070N         P=0.252          P=0.121          P=0.170          P=0.318N                         | 
|LOGISTIC REGRESSION|        P=0.079N         P=0.220          P=0.132          P=0.146          P=0.335N                         | 
|COCH-ARM / FISHERS |        P=0.070N         P=0.243          P=0.106          P=0.166          P=0.314N                         | 
|ORDER RESTRICTED   |        P=0.094N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        0/53 (0%)        1/51 (2%)        1/52 (2%)        0/52 (0%)                        | 
|POLY-3 RATE (b)    |        4/39.21          0/37.40          1/38.82          1/36.79          0/36.27                          | 
|POLY-3 PERCENT (g) |        10.2%            0.0%             2.6%             2.7%             0.0%                             | 
|TERMINAL (d)       |        2/22 (9%)        0/21 (0%)        1/22 (5%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        426              ---              729 (T)          729 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.140N         P=0.070N         P=0.182N         P=0.169N         P=0.063N                         | 
|POLY 3             |        P=0.152N         P=0.065N         P=0.180N         P=0.196N         P=0.069N                         | 
|POLY 1.5           |        P=0.154N         P=0.065N         P=0.182N         P=0.196N         P=0.070N                         | 
|POLY 6             |        P=0.150N         P=0.065N         P=0.179N         P=0.195N         P=0.069N                         | 
|LOGISTIC REGRESSION|        P=0.157N         P=0.064N         P=0.184N         P=0.190N         P=0.067N                         | 
|COCH-ARM / FISHERS |        P=0.152N         P=0.059N         P=0.194N         P=0.187N         P=0.061N                         | 
|ORDER RESTRICTED   |        P=0.008N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 17      
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        13/53 (25%)      14/53 (26%)      17/51 (33%)      16/52 (31%)      7/52 (13%)                       | 
|POLY-3 RATE (b)    |        13/39.63         14/39.56         17/39.94         16/38.93         7/37.39                          | 
|POLY-3 PERCENT (g) |        32.8%            35.4%            42.6%            41.1%            18.7%                            | 
|TERMINAL (d)       |        9/22 (41%)       8/21 (38%)       12/22 (55%)      11/24 (46%)      4/24 (17%)                       | 
|FIRST INCIDENCE    |        426              499              603              499              485                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.021N*        P=0.470          P=0.259          P=0.400          P=0.091N                         | 
|POLY 3             |        P=0.036N*        P=0.498          P=0.246          P=0.294          P=0.121N                         | 
|POLY 1.5           |        P=0.040N*        P=0.484          P=0.241          P=0.284          P=0.128N                         | 
|POLY 6             |        P=0.033N*        P=0.530          P=0.251          P=0.323          P=0.111N                         | 
|LOGISTIC REGRESSION|        P=0.038N*        P=0.477          P=0.271          P=0.283          P=0.125N                         | 
|COCH-ARM / FISHERS |        P=0.035N*        P=0.500          P=0.219          P=0.310          P=0.116N                         | 
|ORDER RESTRICTED   |        P=0.050N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/53 (15%)       7/53 (13%)       7/53 (13%)       6/53 (11%)       3/53 (6%)                        | 
|POLY-3 RATE (b)    |        8/38.61          7/38.70          7/39.39          6/37.45          3/36.71                          | 
|POLY-3 PERCENT (g) |        20.7%            18.1%            17.8%            16.0%            8.2%                             | 
|TERMINAL (d)       |        5/22 (23%)       4/21 (19%)       5/22 (23%)       5/24 (21%)       2/24 (8%)                        | 
|FIRST INCIDENCE    |        640              534              659              715              665                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.056N         P=0.520N         P=0.490N         P=0.330N         P=0.088N                         | 
|POLY 3             |        P=0.087N         P=0.498N         P=0.483N         P=0.407N         P=0.109N                         | 
|POLY 1.5           |        P=0.088N         P=0.507N         P=0.489N         P=0.407N         P=0.112N                         | 
|POLY 6             |        P=0.086N         P=0.481N         P=0.477N         P=0.405N         P=0.105N                         | 
|LOGISTIC REGRESSION|        P=0.079N         P=0.514N         P=0.470N         P=0.368N         P=0.103N                         | 
|COCH-ARM / FISHERS |        P=0.075N         P=0.500N         P=0.500N         P=0.388N         P=0.101N                         | 
|ORDER RESTRICTED   |        P=0.111N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 18      
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/53 (15%)       7/53 (13%)       8/53 (15%)       6/53 (11%)       3/53 (6%)                        | 
|POLY-3 RATE (b)    |        8/38.61          7/38.70          8/40.14          6/37.45          3/36.71                          | 
|POLY-3 PERCENT (g) |        20.7%            18.1%            19.9%            16.0%            8.2%                             | 
|TERMINAL (d)       |        5/22 (23%)       4/21 (19%)       5/22 (23%)       5/24 (21%)       2/24 (8%)                        | 
|FIRST INCIDENCE    |        640              534              458              715              665                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.049N*        P=0.520N         P=0.591N         P=0.330N         P=0.088N                         | 
|POLY 3             |        P=0.078N         P=0.498N         P=0.577N         P=0.407N         P=0.109N                         | 
|POLY 1.5           |        P=0.077N         P=0.507N         P=0.588N         P=0.407N         P=0.112N                         | 
|POLY 6             |        P=0.077N         P=0.481N         P=0.566N         P=0.405N         P=0.105N                         | 
|LOGISTIC REGRESSION|        P=0.071N         P=0.514N         P=0.587N         P=0.368N         P=0.103N                         | 
|COCH-ARM / FISHERS |        P=0.065N         P=0.500N         P=0.607N         P=0.388N         P=0.101N                         | 
|ORDER RESTRICTED   |        P=0.115N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Schwannoma Malignant                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/53 (0%)        2/53 (4%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/39.03          2/38.71          0/36.47                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             5.2%             0.0%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              479              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.726          (e)              (e)              P=0.245          (e)                              | 
|POLY 3             |        P=0.705          (e)              (e)              P=0.239          (e)                              | 
|POLY 1.5           |        P=0.705          (e)              (e)              P=0.236          (e)                              | 
|POLY 6             |        P=0.706          (e)              (e)              P=0.246          (e)                              | 
|LOGISTIC REGRESSION|        P=0.733N         (e)              (e)              P=0.257          (e)                              | 
|COCH-ARM / FISHERS |        P=0.724          (e)              (e)              P=0.248          (e)                              | 
|ORDER RESTRICTED   |        P=0.220          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 19      
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Squamous Cell Carcinoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        1/53 (2%)        1/53 (2%)        4/53 (8%)        0/53 (0%)                        | 
|POLY-3 RATE (b)    |        1/38.18          1/37.40          1/39.03          4/37.49          0/36.47                          | 
|POLY-3 PERCENT (g) |        2.6%             2.7%             2.6%             10.7%            0.0%                             | 
|TERMINAL (d)       |        1/22 (5%)        1/21 (5%)        1/22 (5%)        2/24 (8%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        729 (T)          729 (T)          729 (T)          715              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.344N         P=0.753          P=0.763          P=0.211          P=0.483N                         | 
|POLY 3             |        P=0.397N         P=0.757          P=0.757N         P=0.171          P=0.509N                         | 
|POLY 1.5           |        P=0.397N         P=0.756          P=0.758N         P=0.171          P=0.510N                         | 
|POLY 6             |        P=0.394N         P=0.759          P=0.755N         P=0.173          P=0.507N                         | 
|LOGISTIC REGRESSION|        P=0.361N         P=0.753          P=0.763          P=0.187          (e)                              | 
|COCH-ARM / FISHERS |        P=0.374N         P=0.752N         P=0.752N         P=0.181          P=0.500N                         | 
|ORDER RESTRICTED   |        P=0.249N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/53 (2%)        2/53 (4%)        2/53 (4%)        2/53 (4%)                        | 
|POLY-3 RATE (b)    |        0/38.18          1/38.27          2/39.13          2/37.81          2/36.47                          | 
|POLY-3 PERCENT (g) |        0.0%             2.6%             5.1%             5.3%             5.5%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        1/24 (4%)        2/24 (8%)                        | 
|FIRST INCIDENCE    |        ---              367              705              612              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.328          P=0.488          P=0.252          P=0.240          P=0.257                          | 
|POLY 3             |        P=0.287          P=0.500          P=0.242          P=0.234          P=0.226                          | 
|POLY 1.5           |        P=0.288          P=0.499          P=0.240          P=0.233          P=0.226                          | 
|POLY 6             |        P=0.288          P=0.503          P=0.244          P=0.238          P=0.228                          | 
|LOGISTIC REGRESSION|        P=0.297          P=0.530          P=0.245          P=0.233          P=0.257                          | 
|COCH-ARM / FISHERS |        P=0.310          P=0.500          P=0.248          P=0.248          P=0.248                          | 
|ORDER RESTRICTED   |        P=0.176          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 20      
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        49/53 (92%)      43/53 (81%)      48/53 (91%)      46/53 (87%)      36/53 (68%)                      | 
|POLY-3 RATE (b)    |        49/49.76         43/46.09         48/49.33         46/47.73         36/42.50                         | 
|POLY-3 PERCENT (g) |        98.5%            93.3%            97.3%            96.4%            84.7%                            | 
|TERMINAL (d)       |        22/22 (100%)     20/21 (95%)      22/22 (100%)     23/24 (96%)      22/24 (92%)                      | 
|FIRST INCIDENCE    |        345              296              254              254              314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.021N*        P=0.302N         P=0.463N         P=0.313N         P=0.024N*                        | 
|POLY 3             |        P<0.001N**       P=0.157N         P=0.684N         P=0.494N         P=0.005N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.102N         P=0.550N         P=0.416N         P=0.002N**                       | 
|POLY 6             |        P=0.004N**       P=0.242N         P=0.965N         P=0.515N         P=0.018N*                        | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.099N         P=0.450N         P=0.411N         P=0.002N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.075N         P=0.500N         P=0.263N         P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        14/53 (26%)      18/53 (34%)      14/53 (26%)      23/53 (43%)      37/53 (70%)                      | 
|POLY-3 RATE (b)    |        14/40.90         18/43.06         14/41.95         23/42.72         37/44.23                         | 
|POLY-3 PERCENT (g) |        34.2%            41.8%            33.4%            53.8%            83.7%                            | 
|TERMINAL (d)       |        9/22 (41%)       8/21 (38%)       7/22 (32%)       11/24 (46%)      21/24 (88%)                      | 
|FIRST INCIDENCE    |        377              167              458              142              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.238          P=0.560N         P=0.094          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.308          P=0.560N         P=0.049 *        P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.284          P=0.574N         P=0.044 *        P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.350          P=0.538N         P=0.065          P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.261          P=0.576N         P=0.045 *        P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.263          P=0.587N         P=0.051          P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 21      
Statistical Analysis of Primary Tumors in Rats(SPRAGUE-DAWLEY)       -     TEF EVALUATION (BINARY MIXTURE; PCB 126                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |        #                #                #                #                #                                | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        51/53 (96%)      49/53 (92%)      50/53 (94%)      50/53 (94%)      46/53 (87%)                      | 
|POLY-3 RATE (b)    |        51/51.39         49/50.84         50/50.78         50/50.20         46/48.11                         | 
|POLY-3 PERCENT (g) |        99.2%            96.4%            98.5%            99.6%            95.6%                            | 
|TERMINAL (d)       |        22/22 (100%)     20/21 (95%)      22/22 (100%)     24/24 (100%)     23/24 (96%)                      | 
|FIRST INCIDENCE    |        345              167              254              142              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.218N         P=0.525N         P=0.459N         P=0.421N         P=0.258N                         | 
|POLY 3             |        P=0.252N         P=0.359N         P=0.798N         P=0.973          P=0.254N                         | 
|POLY 1.5           |        P=0.140N         P=0.327N         P=0.635N         P=0.894N         P=0.154N                         | 
|POLY 6             |        P=0.424N         P=0.377N         P=0.985N         P=1.000          P=0.415N                         | 
|LOGISTIC REGRESSION|        P=0.158N         P=0.408N         P=0.479N         P=0.710          P=0.174N                         | 
|COCH-ARM / FISHERS |        P=0.054N         P=0.339N         P=0.500N         P=0.500N         P=0.080N                         | 
|ORDER RESTRICTED   |        P=0.091N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.