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TDMS Study 96020-01 Pathology Tables

NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04
Route: GAVAGE                                                                                                     Time: 10:01:01

                                                            FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFBINARYMIX

       Lock Date:  03/27/02

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 002    10 NG / 10 UG
                               Include 003    100 NG /100 UG
                               Include 005    300 NG /300 UG
                               Include 007    1000 NG/1000 UG































                                                              Page   1


NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6|             
                                           | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    0 UG                                   | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1                                1                                    |             
      Basophilic Focus                     | X                 X              X        X     X     X        X         |             
      Basophilic Focus, Multiple           |             X  X     X                                                   |             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |    X  X                                                              X   |             
      Eosinophilic Focus                   |                         X           X        X     X                    X|             
      Eosinophilic Focus, Multiple         |                X                          X           X                  |             
      Fatty Change, Diffuse                |       1                          2                          2            |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                1  1  1     1        1  1     2  1  1  1  1  2        1  1|             
      Inflammation                         | 1  1  1  1        1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Mixed Cell Focus                     |                                           X     X        X              X|             
      Mixed Cell Focus, Multiple           |    X  X     X                 X     X  X           X  X                  |             
      Necrosis                             |                   1              2                                       |             
      Pigmentation                         |       1                                                                  |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Fibrosis                  |                                                                          |             
      Bile Duct, Hyperplasia               |             1     1                                               1      |             
      Centrilobular, Degeneration          |                                  2                          3  2         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6|             
                                           | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    0 UG                                   | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hepatocyte, Hypertrophy              |                                                                          |             
      Oval Cell, Hyperplasia               |                                                                          |             
      Serosa, Inflammation, Chronic Active | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +                 +  +  +  +  +        +                          +   |             
      Gingival, Hyperplasia, Squamous      |                         1  1  1  1                                   2   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Mineralization                       |                                                                      1   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1                    1           2     2                                 |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +        +        +  +  +  +  +                    +              +  +|             
      Peridontal Tissue, Inflammation      | 1  1        1        1  1  2  2  1                    1              2  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1              1        1  1           1           1  1  1        1|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1  2     1        1                                   1               |             
      Degeneration, Cystic                 |                      2        3     1  3           2              2  2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6|             
                                           | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    0 UG                                   | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |             2           2           2  3                                 |             
      Hypertrophy                          | 2  2  2        2  2  3  2     3  2  3  2  1  3     2  1  1  2  2  2  2  2|             
      Necrosis                             |                                  3                                       |             
      Vacuolization Cytoplasmic            |    3                    2  1        1        1                          2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2     2  1              2  2  1     3              2      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2        2              3     2                          2|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |    2  3              2        2                    1     3     2  3  2   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             2  1        4                    2  3  3                     |             
      Follicle, Cyst                       |                                        2                             2   |             
      Follicular Cell, Hypertrophy         | 1                          1  1     2              1  1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  2  2  2  1  2  2  2  3  2  1     2  1  1  1  2  1     2  2  1  3  2  2|             
      Duct, Cyst                           | 3  2  2  2  2  2  2  1  2  3        3  3        2  2  1  2  2  2  2  3  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4     4  4  4  4     4     4  4  4     3  4  4  4  4  4|             
      Cyst                                 |       2        3        2  2  2  2        2  3                           |             
      Inflammation, Chronic Active         |                            2                                             |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6|             
                                           | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    0 UG                                   | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2                 3                    2                                 |             
      Inflammation, Suppurative            |          1     1                 2                                       |             
      Metaplasia, Squamous                 | 4        3  2  3  2        2  4        3  1        1           2  2      |             
      Endometrium, Hyperplasia, Cystic     |    2  2  2              2  2     1        3  3  1  2              2  2   |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4        4     4  4  4     4  2  3  3  3  3  4  3  4  3  4  3  3  2  3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                       +     +            |             
      Lumbar, Ectasia                      |                                                       2     2            |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                       2     2            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |    2  2     2  2  2  2  2     2     2  2     2     2  2  2  2  2         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  2  2  3  2  2  3  4  1  2  2  3  3  2  2  2  3  3  3  4  3  2  2  1  2|             
      Pigmentation                         |    1  2  1  1  1        2  1  2  1  1  2     1  2  1  1  1     1  2  2  1|             
      Red Pulp, Atrophy                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3           2     2  2     3  4     2  2  4              2     3      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6|             
                                           | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    0 UG                                   | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Cyst                                 |          3                                                               |             
      Hyperplasia                          |       1     2  1     2  1  1  2     1  2     2     2  2  1               |             
      Inflammation, Granulomatous          |          2              2                                         1      |             
      Duct, Cyst                           |                                        4                                 |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  1  2  1  1  2  2  2  2  1  3  2  2  2  1  3  2  2        2     2  3  2|             
      Inflammation                         |       2                             2                                1   |             
      Alveolar Epithelium, Hyperplasia     |       2  1                    1     1  1     2     1        1     1  2  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2  1              2     1  2  2        1  1                       3   |             
      Olfactory Epithelium, Degeneration   |                                                                          |             
      Olfactory Epithelium, Metaplasia     |                                                                      3   |             
      Respiratory Epithelium, Hyperplasia  | 2                             3              3                       3   |             
      Respiratory Epithelium, Metaplasia   |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 7| 6| 5| 5| 7| 4| 7| 6| 5| 7| 6| 7| 3| 6| 4| 4| 4| 6| 7| 6| 6|             
                             DAY ON TEST   | 2| 3| 3| 4| 2| 6| 3| 5| 1| 5| 3| 6| 5| 2| 4| 2| 7| 4| 5| 8| 4| 8| 2| 6| 6|             
                                           | 9| 0| 1| 5| 9| 4| 3| 6| 4| 1| 1| 4| 6| 9| 0| 9| 7| 7| 1| 4| 9| 4| 9| 4| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    0 UG                                   | 1| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 8| 0| 1| 2| 4| 5| 1| 2| 3| 4| 6| 9|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1              1  1           1                                      1  1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                             2            |             
      Calculus Micro Observation Only      |                               X                    X                 X   |             
      Casts Protein                        |          2                                                               |             
      Inflammation, Chronic Active         |          2                                                               |             
      Inflammation, Suppurative            | 1  2                    1     1                                          |             
      Mineralization                       | 1  1  1  1     1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Nephropathy                          |    1  2  1  1  1     1  1     1        1     1  1                 1     1|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation                 |                      1                                                   |             
      Transitional Epithelium, Hyperplasia |                               1                                          |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Inflammation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1     1                                                         |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9|             
                                           | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    0 UG                                   | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             | 1     1                                                           2      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          3                                                               |             
      Basophilic Focus                     |                            X                                             |             
      Basophilic Focus, Multiple           |          X     X  X  X        X  X  X                 X           X      |             
      Clear Cell Focus                     | X                                   X                                    |             
      Clear Cell Focus, Multiple           |                            X                 X                 X         |             
      Eosinophilic Focus                   |                                                                   X     X|             
      Eosinophilic Focus, Multiple         |    X              X              X  X                                    |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                                                                   1      |             
      Hematopoietic Cell Proliferation     |    1  1  1  1  1        2        1                 1  1     1           3|             
      Inflammation                         | 1  1  1  1  2  1  1  1  1  1  1  1  1  1  1     1  1  1        1     1   |             
      Mixed Cell Focus                     |                                  X                                   X  X|             
      Mixed Cell Focus, Multiple           | X        X           X     X                 X  X  X        X  X         |             
      Necrosis                             |             2                                         2                  |             
      Pigmentation                         |                                     1                                    |             
      Bile Duct, Cyst                      |                   2              3  1                       3            |             
      Bile Duct, Fibrosis                  |                               1                                          |             
      Bile Duct, Hyperplasia               |                               3  1     1                          1      |             
      Centrilobular, Degeneration          |                                                 1     1                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9|             
                                           | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    0 UG                                   | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hepatocyte, Hypertrophy              |    1                                                                     |             
      Oval Cell, Hyperplasia               |                                  1  1                                    |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                       1                  |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |             +                       +              +              +      |             
      Gingival, Hyperplasia, Squamous      |             1                       1              2                     |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia                  |                                              2                       1   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                      2   |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |          +  +  +  +                 +  +     +     +  +     +     +  +   |             
      Peridontal Tissue, Inflammation      |          1  1  1  1                 2  1     1     1  1     2     1  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        1     1  1  1  1        1           1  1                    1   |             
      Inflammation, Chronic Active         |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                1           2     2  2     1  1  1        2        1  2   |             
      Degeneration, Cystic                 | 1  2     3                                         1        2        3   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9|             
                                           | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    0 UG                                   | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                         1|             
      Hyperplasia                          |                      2     3        2        2                    2     2|             
      Hypertrophy                          | 2  2     2  2  2  2  2  1  2  2  1  3  3  2  3  2  2     1  2  3  1  2  2|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                            1           1     1                          1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |          1     1                    2  2     2  2                        |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2        1        2  2  2  3     3  2     4     2        3           3   |             
      Cyst                                 |                   2                                                      |             
      Pars Distalis, Hyperplasia           |             3                                                            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2     2        2  1  1        3     2  2                 2            |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hypertrophy         |    1                    1              2                 2  1  1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2     2  1  2  2     2     2  2     2  2  1  2  1  2  1  1  4        2|             
      Duct, Cyst                           | 2  3     2  1  2  2     3     3  2     3  1  3     2        1           2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4        4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4        4  3|             
      Cyst                                 |                                        2     2  3              3        2|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                     +                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9|             
                                           | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    0 UG                                   | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Cyst                                 |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 | 1        2  1  2  1  2  2     2              2  2  4     1  1           1|             
      Endometrium, Hyperplasia, Cystic     | 2              2     2  3  1  2  2        1  2  2     2     2        1   |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3     3  3     2  4  3     4  3  2  2     2  4  4     3     2     4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +              +                                             |             
      Lumbar, Ectasia                      |             2              3                                             |             
      Lumbar, Hyperplasia, Plasma Cell     |             2              3                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                            2                                             |             
      Hyperplasia, Plasma Cell             | 2        3     2  3  3  3  2  2  2        3  3  2  2     3  2  2  2  3  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  3  2  1  4  2  1  1  3  1     2  2  2     1  1  2  4  1  2  2  2  2  4|             
      Pigmentation                         | 2  1  2  2  1  1  2  2     1  2  1  2  2  3  1  2  1  1  2  1  2  2  1  1|             
      Red Pulp, Atrophy                    |                               2                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2     2  2     3  2  2  3  2  2  2        2  1  2  2     3  2  2  2  1|             
      Hemorrhage                           |                                                          2               |             
      Hyperplasia, Lymphoid                |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9|             
                                           | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    0 UG                                   | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Cyst                                 |                                           3  3                           |             
      Hyperplasia                          | 1  2     1  2     1  1           2  1  2        1        1     2  2  2  1|             
      Inflammation, Granulomatous          |                                     2     3                              |             
      Duct, Cyst                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  1     1  1  2  1  2  2  2  2  2  2  2     1  2  2  2  2  2  2  2  1  2|             
      Inflammation                         |       3                          1     2           2           1         |             
      Alveolar Epithelium, Hyperplasia     | 1        1           1     2  1  1  1  1                    1  1         |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1        1           2              2                 2  1  2  1  1   |             
      Olfactory Epithelium, Degeneration   | 2                                                                        |             
      Olfactory Epithelium, Metaplasia     |                                                                2  3      |             
      Respiratory Epithelium, Hyperplasia  |                         2              2                 2     2  3      |             
      Respiratory Epithelium, Metaplasia   |                         2                                                |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 0| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 7| 6| 6| 4| 6| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 8| 3| 3| 1| 2| 3| 8| 3| 7| 3| 2| 3| 2| 2| 3| 5| 8| 1| 5| 3| 0| 2| 9|             
                                           | 0| 6| 5| 1| 6| 9| 9| 1| 1| 1| 0| 1| 9| 1| 6| 9| 0| 4| 8| 8| 4| 1| 8| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG /                                 | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    0 UG                                   | 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                            +                                             |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                            2                                             |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1     1  1  1        1  1        1        1           1     1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                         2|             
      Calculus Micro Observation Only      | X        X                 X     X                                       |             
      Casts Protein                        |                               2                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                  1                                       |             
      Mineralization                       | 1     1  1  1  1  1  1  1  1  1  2     1           1  1  1  1     1  1   |             
      Nephropathy                          | 1  1     1  1           1  1     1     1  1  2  3              2     2  1|             
      Pelvis, Dilatation                   |                            2                                             |             
      Pelvis, Inflammation                 |                            3                                            2|             
      Transitional Epithelium, Hyperplasia |                            3                                             |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                            +                                             |             
      Inflammation                         |                            2                                             |             
      Transitional Epithelium, Hyperplasia |                            3                                             |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1                          2           1                                1|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4|                                                                 |            |
                             DAY ON TEST   | 2| 3| 5|                                                                 |            |
                                           | 9| 1| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 4| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      3  1.7|
      Basophilic Focus                     |    X                                                                     |      9     |
      Basophilic Focus, Multiple           |       X                                                                  |     13     |
      Clear Cell Focus                     |    X                                                                     |      3     |
      Clear Cell Focus, Multiple           |                                                                          |      6     |
      Eosinophilic Focus                   |                                                                          |      7     |
      Eosinophilic Focus, Multiple         |                                                                          |      7     |
      Fatty Change, Diffuse                |                                                                          |      3  1.7|
      Fatty Change, Focal                  | 1  1                                                                     |      3  1.0|
      Hematopoietic Cell Proliferation     | 1     1                                                                  |     27  1.2|
      Inflammation                         |    2                                                                     |     44  1.1|
      Mixed Cell Focus                     |                                                                          |      7     |
      Mixed Cell Focus, Multiple           | X  X                                                                     |     19     |
      Necrosis                             |                                                                          |      4  1.8|
      Pigmentation                         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4|                                                                 |            |
                             DAY ON TEST   | 2| 3| 5|                                                                 |            |
                                           | 9| 1| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 4| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Bile Duct, Cyst                      |                                                                          |      4  2.3|
      Bile Duct, Fibrosis                  |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |    1                                                                     |      8  1.3|
      Centrilobular, Degeneration          |                                                                          |      5  1.8|
      Hepatocyte, Hypertrophy              |                                                                          |      1  1.0|
      Oval Cell, Hyperplasia               |                                                                          |      2  1.0|
      Serosa, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  M  +                                                                  |  47        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |  12        |
      Gingival, Hyperplasia, Squamous      |                                                                          |      8  1.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Acinus, Hyperplasia                  |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  23        |
      Peridontal Tissue, Inflammation      |                                                                          |     23  1.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4|                                                                 |            |
                             DAY ON TEST   | 2| 3| 5|                                                                 |            |
                                           | 9| 1| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 4| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
      Cardiomyopathy                       | 1                                                                        |     22  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          | 1  2                                                                     |     17  1.4|
      Degeneration, Cystic                 |                                                                          |     13  2.1|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          | 2                                                                        |     11  2.2|
      Hypertrophy                          | 2  3  1                                                                  |     47  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            | 2                                                                        |     11  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Hyperplasia                          |    2                                                                     |     15  1.8|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M                                                                  |  45        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |     17  2.4|
      Cyst                                 |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           | 3  1  4                                                                  |     13  2.4|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  |                                                                          |     15  2.1|
      Follicle, Cyst                       |                                                                          |      2  2.0|
      Follicular Cell, Hypertrophy         | 1     2                                                                  |     14  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4|                                                                 |            |
                             DAY ON TEST   | 2| 3| 5|                                                                 |            |
                                           | 9| 1| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 4| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         | 3  2  2                                                                  |     45  1.8|
      Duct, Cyst                           | 1     3                                                                  |     38  2.1|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4  4                                                                  |     45  4.0|
      Cyst                                 |    3                                                                     |     14  2.4|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      3  2.3|
      Inflammation, Suppurative            |                                                                          |      3  1.3|
      Metaplasia, Squamous                 | 2                                                                        |     27  2.0|
      Endometrium, Hyperplasia, Cystic     | 3  3  3                                                                  |     28  2.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 3     3                                                                  |     39  3.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   4        |
      Lumbar, Ectasia                      |                                                                          |      4  2.3|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             | 2  3                                                                     |     37  2.2|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4|                                                                 |            |
                             DAY ON TEST   | 2| 3| 5|                                                                 |            |
                                           | 9| 1| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 4| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 2  2  2                                                                  |     51  2.2|
      Pigmentation                         | 2  2  1                                                                  |     47  1.5|
      Red Pulp, Atrophy                    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  53        |
      Atrophy                              | 2  2                                                                     |     33  2.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      3  3.0|
      Hyperplasia                          |    1                                                                     |     29  1.5|
      Inflammation, Granulomatous          |                                                                          |      5  2.0|
      Duct, Cyst                           |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Angiectasis                          |    3                                                                     |      1  3.0|
      Fibrosis                             |    3                                                                     |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4|                                                                 |            |
                             DAY ON TEST   | 2| 3| 5|                                                                 |            |
                                           | 9| 1| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 4| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 2  2                                                                     |     47  1.8|
      Inflammation                         |                                                                          |      8  1.8|
      Alveolar Epithelium, Hyperplasia     | 1  1                                                                     |     23  1.2|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |    2  1                                                                  |     22  1.5|
      Olfactory Epithelium, Degeneration   |                                                                          |      1  2.0|
      Olfactory Epithelium, Metaplasia     |    1                                                                     |      4  2.3|
      Respiratory Epithelium, Hyperplasia  |    2                                                                     |     10  2.4|
      Respiratory Epithelium, Metaplasia   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Retina, Atrophy                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         | 1                                                                        |     20  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Accumulation, Hyaline Droplet        |                                                                          |      2  2.0|
      Calculus Micro Observation Only      |                                                                          |      7     |
      Casts Protein                        |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      5  1.2|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4|                                                                 |            |
                             DAY ON TEST   | 2| 3| 5|                                                                 |            |
                                           | 9| 1| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG /                                 | 9| 9| 9|                                                                 |      L     |
    0 UG                                   | 4| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Mineralization                       |       1                                                                  |     42  1.0|
      Nephropathy                          |    1  1                                                                  |     29  1.2|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Pelvis, Inflammation                 |                                                                          |      3  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |       1                                                                  |      7  1.1|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6|             
                                           | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 NG /                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    10 UG                                  | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                          X                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               1                                          |             
      Basophilic Focus                     |                X        X  X                             X               |             
      Basophilic Focus, Multiple           |    X                 X        X              X                       X   |             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   |                            X                                X            |             
      Eosinophilic Focus, Multiple         |    X                    X     X              X  X              X         |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |       1                                                     1            |             
      Hematopoietic Cell Proliferation     |             1  1  1  1     2  1  1  1  1  1                 1     1  1   |             
      Hepatodiaphragmatic Nodule           |                X                                                         |             
      Inflammation                         |    1     1     1     1  1  1  1  1  2     1  1  1  1  1     1  1  1  1   |             
      Mixed Cell Focus                     |       X           X                                                      |             
      Mixed Cell Focus, Multiple           |    X     X                    X              X           X  X            |             
      Necrosis                             | 2                    2              3     2           2                  |             
      Pigmentation                         |    2                    1  1                                             |             
      Toxic Hepatopathy                    |                            1                                             |             
      Bile Duct, Cyst                      |    3                                                                     |             
      Bile Duct, Dilatation                |    4                                                                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6|             
                                           | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 NG /                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    10 UG                                  | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |                   1                                      1               |             
      Bile Duct, Hyperplasia               |    2                                                                     |             
      Centrilobular, Degeneration          |                            2              2           3              1   |             
      Hepatocyte, Hypertrophy              |       1                    1              1     1  1                     |             
      Oval Cell, Hyperplasia               |    1                                                                     |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                      1   |             
      Fat, Necrosis                        |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +                             +  +  +              +                  |             
      Gingival, Hyperplasia, Squamous      | 1                                1  1  1              1                  |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               1                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Mineralization                       |                                                                2         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   1                       2                              |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +              +              +  +  +              +  +               |             
      Peridontal Tissue, Inflammation      |    1              1              3  2  2              2  2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1                    1  1     1     1        1           1        1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6|             
                                           | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 NG /                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    10 UG                                  | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1  2  2        1  2  2     2              1  1        2  2        2   |             
      Degeneration, Cystic                 |          2     2              3                          2               |             
      Hyperplasia                          | 2  1  1  3        1     2     3                 2                    3   |             
      Hypertrophy                          |    2  2  3     2  2     2  1  3  2  2     1  3  2     1  3  1  4  1      |             
      Vacuolization Cytoplasmic            |                                           1  2                 2     2  2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1        2     2              2                    1   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Hyperplasia                          |                                           2                              |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3        3     3  3  2  2  1           1           2        2      |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |          2        2           3  4     3  2  3  2                        |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       3                 3                    3  2                 2  2   |             
      Follicular Cell, Hypertrophy         |                1  1  1                 1        2                 2  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2  2  1     2  2  2  2  1  2  2  2  2  1  3  3  2  2  3  2  1  2  2   |             
      Duct, Cyst                           | 2  1  3  1           2  2  2  3  1  1  2  1  2  2  2  1  3  3     2  3  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4     4     4  4  4  4     4  4  4  4  4  4  4  4     4     4  4  4   |             
      Cyst                                 |                3              2                                      2   |             
      Inflammation, Chronic Active         |                                                 4                        |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6|             
                                           | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 NG /                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    10 UG                                  | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                         2                       2                        |             
      Metaplasia, Squamous                 |    1     2     4  4  2     1  2     1  2     1  2  4           2     1   |             
      Endometrium, Hyperplasia, Cystic     |    2     3           2  2     2  4           1  3                    2   |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3                                                                  |             
      Hyperplasia                          | 3  2     2  3  3  3  3     3  2  3  3  4  3     3  3  3        3  4  3   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +                                   +                 +  +  +|             
      Lumbar, Ectasia                      |                                                 2                 2  2   |             
      Lumbar, Hemorrhage                   |                                                                      2   |             
      Lumbar, Hyperplasia                  |                                                 3                        |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                   2      |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Renal, Ectasia                       |                                                 2                        |             
      Renal, Hyperplasia, Plasma Cell      |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                 2                        |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |          2                                                               |             
      Hyperplasia, Plasma Cell             |    3  2  2     2     3  2        3  2        2  2  2  2  2  2  3  2  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2     2  2  2  2  3  1  3  2  3  2  2  3  2  2  2  2  2  2  2  3  2   |             
      Pigmentation                         | 1  2  3  2     1  1  1  3  1  2        1  1  1  2  1  1  2  2  2  1  1   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  3  2  4  2     2  3        3     2  3  2  2  3           2     4   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6|             
                                           | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 NG /                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    10 UG                                  | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     2                                    |             
      Hyperplasia                          |       2  1     1     1  2     1  1        2     1     1     2  1  3      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 3  2  3  2  1  2  2     2  2  2  1  1  1  1  2  2        2  2  2  2  2   |             
      Inflammation                         |                   3                                                      |             
      Mineralization                       |                                           1                              |             
      Alveolar Epithelium, Hyperplasia     | 2  2     1        1     1  1  1              1  2           2     1  1   |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 1  1  1  2                                                               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    2                 1        1                 1                    1   |             
      Olfactory Epithelium, Metaplasia     |    2                    2                                            2   |             
      Respiratory Epithelium, Hyperplasia  |    2                                            2                    2   |             
      Respiratory Epithelium,              |                                                                          |             
          Vacuolization Cytoplasmic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 1| 6| 5| 6| 6| 6| 7| 6| 6| 7| 5| 7| 7| 3| 4| 7| 7| 6| 7| 7| 3|             
                             DAY ON TEST   | 2| 3| 9| 3| 6| 8| 3| 3| 8| 6| 3| 6| 3| 2| 3| 3| 3| 7| 9| 2| 2| 3| 2| 2| 6|             
                                           | 7| 1| 8| 1| 7| 9| 4| 6| 9| 1| 1| 4| 9| 0| 4| 0| 1| 8| 9| 9| 9| 6| 9| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 NG /                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    10 UG                                  | 1| 3| 4| 5| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                            2                 2                           |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1        1     1           1              1                 1  1   |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      | X     X                                                                  |             
      Casts Protein                        |                                                                          |             
      Cyst                                 |    3                                                                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                              1                           |             
      Mineralization                       | 1  1           1  1  1  1     1  1  1  1  3  1  1  1  1  1     1     1  1|             
      Nephropathy                          |    1  1  1           1  1  1  1                 1        1  1  1     1   |             
      Pigmentation                         |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                         +|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1              1                                   1               |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5|             
                             DAY ON TEST   | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8|             
                                           | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 NG /                                | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8|             
    10 UG                                  | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                           3                              |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       X                    X                                            X|             
      Basophilic Focus, Multiple           |          X  X     X              X                 X  X              X   |             
      Cholangiofibrosis                    |                                     1                                    |             
      Clear Cell Focus                     |                   X                                X                     |             
      Clear Cell Focus, Multiple           |                                                                      X   |             
      Eosinophilic Focus                   |       X     X                                   X     X                  |             
      Eosinophilic Focus, Multiple         |                   X                                                      |             
      Fatty Change, Diffuse                |                         1                                                |             
      Fatty Change, Focal                  |             1  1                                                         |             
      Hematopoietic Cell Proliferation     |       1     1     1     1  1  1     1  1  1     1  1  1              1   |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Inflammation                         | 1  1  1  1     1  1  1  1  1  1  1     1  1  1  1        1  1  2  1  1   |             
      Mixed Cell Focus                     |                                                    X                     |             
      Mixed Cell Focus, Multiple           |       X  X  X  X  X  X     X     X        X     X           X        X   |             
      Necrosis                             |                      1        2              2                           |             
      Pigmentation                         |                            1        1                                    |             
      Toxic Hepatopathy                    |                                     1                                    |             
      Bile Duct, Cyst                      |                   2                 2                                    |             
      Bile Duct, Dilatation                |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5|             
                             DAY ON TEST   | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8|             
                                           | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 NG /                                | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8|             
    10 UG                                  | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |                                                                          |             
      Bile Duct, Hyperplasia               |                            1                                             |             
      Centrilobular, Degeneration          |                            1  3     2                                    |             
      Hepatocyte, Hypertrophy              |                                           1                              |             
      Oval Cell, Hyperplasia               |                      1                                                   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                3                                                         |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                +           +                 +           +               |             
      Gingival, Hyperplasia, Squamous      |                1           1                                             |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       2     1                                                            |             
      Acinus, Atrophy                      |       2     1                                                            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                         1|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               1                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |          +     +  +        +     +                       +               |             
      Peridontal Tissue, Inflammation      |          1     1  1        2     1                       1               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2     1     1     1     1        1                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5|             
                             DAY ON TEST   | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8|             
                                           | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 NG /                                | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8|             
    10 UG                                  | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2        2  2     2  1           2     2  1              2           2  1|             
      Degeneration, Cystic                 |       3        3  2  1           2                       3           2   |             
      Hyperplasia                          |       2  2           3     2     2        3                 2            |             
      Hypertrophy                          | 2     1  2  2  3  3     2  2  1  1     2  2        1  1  2           2  1|             
      Vacuolization Cytoplasmic            |          1                    2     2  1                 1  2            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2  2  1                       2                          1  2|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3              1  3     2           2     1           3           1  3|             
      Cyst                                 |                         2                                   3     3      |             
      Pars Distalis, Hyperplasia           |                         2        2           2     2                     |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2  2  3     1     1        1  1  2           2                 1  2|             
      Follicular Cell, Hypertrophy         |          1  1        2     3           1  1     1           1        1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1     1  2  1  2  3  2  1  1     2  2  1  2  1  2  2  1  1  2  2  2  2  2|             
      Duct, Cyst                           |       3  3  2     1  2  2  1        3     2  3     2     2  1  2  3  2  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4     4  4  4     4  4|             
      Cyst                                 |                2                       2  2                             2|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5|             
                             DAY ON TEST   | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8|             
                                           | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 NG /                                | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8|             
    10 UG                                  | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3                              |             
      Inflammation, Suppurative            |                2     2                                         1         |             
      Metaplasia, Squamous                 | 2  4  1  1     3     4     3     2  3     1  2  2           2  2     4   |             
      Endometrium, Hyperplasia, Cystic     | 3     3           3     2        2     3  2        1  1     2  1        1|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 3  3  4        3     2  3  3  2     4  3  3  3  3  4  4     3  3  2      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                             +  +         |             
      Lumbar, Ectasia                      |                                                             3            |             
      Lumbar, Hemorrhage                   |                                                             2            |             
      Lumbar, Hyperplasia                  |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                2         |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                2         |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Ectasia                              |                         2                                                |             
      Hemorrhage                           |             2                                                            |             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Hyperplasia, Plasma Cell             | 2  2  2  2  3  2  2  2     2     2     2  2        3     2  2  2        3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  3  2  2  2  2  2  3  2  3  2  3  2  3  3  1  2  2  2  2  2  1  2  1|             
      Pigmentation                         | 2  1     2  2  1  1  2  1  1  1  2  1  1        1  1  1  3  1  2  1  1  2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +|             
      Atrophy                              | 2  3  3     2  4  1  2  4           2  2  2        2                 2  3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5|             
                             DAY ON TEST   | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8|             
                                           | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 NG /                                | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8|             
    10 UG                                  | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         2                                                |             
      Hyperplasia                          |    1  1  2  2  1  1  2           1        1        1     2  1           1|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |    2  2  3     2  2  2     2  1     2  2  2  2  1  2        3  2        2|             
      Inflammation                         |                1  1                                3              3      |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          2     1  2  1                 2  1                             1|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |                2                                   2                     |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1                    1  1     1           1     1              2      |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                         1        2                                       |             
      Respiratory Epithelium,              |                                                                          |             
          Vacuolization Cytoplasmic        |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 7| 5| 5| 6| 7| 4| 6| 6| 6| 3| 7| 2| 7| 4| 3| 1| 7| 5|             
                             DAY ON TEST   | 6| 8| 2| 3| 2| 3| 2| 3| 8| 6| 0| 2| 0| 8| 6| 4| 3| 3| 9| 2| 6| 3| 7| 3| 8|             
                                           | 9| 0| 9| 0| 9| 0| 9| 1| 9| 3| 3| 9| 7| 9| 1| 3| 0| 1| 6| 9| 9| 7| 8| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 NG /                                | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 8| 8| 8|             
    10 UG                                  | 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 1| 2| 3| 4| 5| 7| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                           1        1     2              1|             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           | X                                                                        |             
      Calculus Micro Observation Only      |       X                       X                                          |             
      Casts Protein                        |                                                          1               |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                            2                                             |             
      Inflammation, Suppurative            |          1           2                                                   |             
      Mineralization                       |       1  1     1  1  1  1  1  1  1     1        1  1     1  1     1  1  1|             
      Nephropathy                          |          1     1     1  1        1                             1     1   |             
      Pigmentation                         |       2                                                                  |             
      Transitional Epithelium, Hyperplasia |                      1                                            1      |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2                          1           1  1                             1|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 3| 9| 2|                                                                 |            |
                                           | 1| 4| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    10 NG /                                | 8| 8| 8|                                                                 |      L     |
    10 UG                                  | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                          |      7     |
      Basophilic Focus, Multiple           | X  X  X                                                                  |     15     |
      Cholangiofibrosis                    |                                                                          |      1  1.0|
      Clear Cell Focus                     |                                                                          |      2     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Eosinophilic Focus                   | X  X                                                                     |      8     |
      Eosinophilic Focus, Multiple         |       X                                                                  |      8     |
      Fatty Change, Diffuse                |                                                                          |      1  1.0|
      Fatty Change, Focal                  |                                                                          |      4  1.0|
      Hematopoietic Cell Proliferation     | 1  1  1                                                                  |     29  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation                         | 1  1  1                                                                  |     41  1.0|
      Mixed Cell Focus                     |                                                                          |      3     |
      Mixed Cell Focus, Multiple           | X                                                                        |     19     |
      Necrosis                             |                                                                          |      8  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 3| 9| 2|                                                                 |            |
                                           | 1| 4| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    10 NG /                                | 8| 8| 8|                                                                 |      L     |
    10 UG                                  | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Pigmentation                         |                                                                          |      5  1.2|
      Toxic Hepatopathy                    |                                                                          |      2  1.0|
      Bile Duct, Cyst                      |                                                                          |      3  2.3|
      Bile Duct, Dilatation                |                                                                          |      1  4.0|
      Bile Duct, Fibrosis                  | 1                                                                        |      3  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      2  1.5|
      Centrilobular, Degeneration          |                                                                          |      7  2.0|
      Hepatocyte, Hypertrophy              | 1                                                                        |      7  1.0|
      Oval Cell, Hyperplasia               |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  M  +                                                                  |  47        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  1.0|
      Fat, Necrosis                        |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |       +                                                                  |  11        |
      Gingival, Hyperplasia, Squamous      |       1                                                                  |      8  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      3  1.3|
      Acinus, Atrophy                      |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperplasia, Squamous                |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |  14        |
      Peridontal Tissue, Inflammation      |       2                                                                  |     14  1.6|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 3| 9| 2|                                                                 |            |
                                           | 1| 4| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    10 NG /                                | 8| 8| 8|                                                                 |      L     |
    10 UG                                  | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Cardiomyopathy                       | 1  1  1                                                                  |     19  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          | 2  1  2                                                                  |     26  1.7|
      Degeneration, Cystic                 | 2                                                                        |     12  2.3|
      Hyperplasia                          | 2  3                                                                     |     18  2.2|
      Hypertrophy                          | 2  2  1                                                                  |     38  1.9|
      Vacuolization Cytoplasmic            |    1                                                                     |     12  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          | 2     3                                                                  |     13  1.8|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  47        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |       3                                                                  |     20  2.2|
      Cyst                                 |                                                                          |      3  2.7|
      Pars Distalis, Hyperplasia           | 3                                                                        |     13  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      C-Cell, Hyperplasia                  | 2     2                                                                  |     19  1.9|
      Follicular Cell, Hypertrophy         | 1                                                                        |     17  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 3| 9| 2|                                                                 |            |
                                           | 1| 4| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    10 NG /                                | 8| 8| 8|                                                                 |      L     |
    10 UG                                  | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         | 2  1  2                                                                  |     49  1.8|
      Duct, Cyst                           |    1  3                                                                  |     40  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  3  3                                                                  |     44  4.0|
      Cyst                                 |                                                                          |      7  2.1|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      5  1.8|
      Metaplasia, Squamous                 | 2                                                                        |     30  2.2|
      Endometrium, Hyperplasia, Cystic     | 2     2                                                                  |     23  2.1|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia                          |    3                                                                     |     38  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   7        |
      Lumbar, Ectasia                      |                                                                          |      4  2.3|
      Lumbar, Hemorrhage                   |                                                                          |      2  2.0|
      Lumbar, Hyperplasia                  |                                                                          |      1  3.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Renal, Ectasia                       |                                                                          |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 3| 9| 2|                                                                 |            |
                                           | 1| 4| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    10 NG /                                | 8| 8| 8|                                                                 |      L     |
    10 UG                                  | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Ectasia                              |       2                                                                  |      3  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             | 2  2  2                                                                  |     37  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 2  2  2                                                                  |     51  2.1|
      Pigmentation                         | 2  1  2                                                                  |     46  1.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  50        |
      Atrophy                              | 3  2  2                                                                  |     33  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      2  2.0|
      Hyperplasia                          | 1  1  2                                                                  |     29  1.4|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 3| 9| 2|                                                                 |            |
                                           | 1| 4| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    10 NG /                                | 8| 8| 8|                                                                 |      L     |
    10 UG                                  | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 2  1  1                                                                  |     41  1.9|
      Inflammation                         |                                                                          |      5  2.2|
      Mineralization                       |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |       1                                                                  |     20  1.4|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |                                                                          |      6  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         | 1                                                                        |     13  1.2|
      Olfactory Epithelium, Metaplasia     |                                                                          |      3  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      5  1.8|
      Respiratory Epithelium,              |                                                                          |            |
          Vacuolization Cytoplasmic        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Retina, Atrophy                      |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         | 1  1  1                                                                  |     14  1.1|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      4     |
      Casts Protein                        |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7|                                                                 |            |
                             DAY ON TEST   | 3| 9| 2|                                                                 |            |
                                           | 1| 4| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 1| 1| 1|                                                                 |      A     |
    10 NG /                                | 8| 8| 8|                                                                 |      L     |
    10 UG                                  | 4| 5| 6|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      3  1.3|
      Mineralization                       |    1  1                                                                  |     38  1.1|
      Nephropathy                          | 1  1  2                                                                  |     22  1.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      8  1.1|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2|             
                                           | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    100 UG                                 | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                                          |             
      Muscularis, Inflammation             |                                        2                                 |             
      Periesophageal Tissue, Inflammation  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       1                  |             
      Basophilic Focus                     | X                 X  X                    X                              |             
      Basophilic Focus, Multiple           |       X                          X                          X  X         |             
      Clear Cell Focus                     |                                  X                                       |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   |                                           X                              |             
      Eosinophilic Focus, Multiple         |       X     X        X     X  X                 X  X  X           X     X|             
      Fatty Change, Diffuse                |          3                       1                          1            |             
      Fatty Change, Focal                  | 1  1                 1        1                                          |             
      Hematopoietic Cell Proliferation     | 1     1        1           1  1     1  1  1     1     1  2        1  1  1|             
      Hyperplasia, Nodular                 |                               X                                          |             
      Inflammation                         | 1  1  1  1  1  1  2  1  1  1  1  1  1           1  1  1  1  1  1  1  1  1|             
      Mixed Cell Focus                     |                         X                             X                  |             
      Mixed Cell Focus, Multiple           | X  X  X     X  X     X     X  X  X     X  X     X           X  X         |             
      Necrosis                             |       2                             1                                2   |             
      Pigmentation                         | 1  1  2  1  1  1  2  1  1     1  2  1        1     2  1     1  1  2  1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2|             
                                           | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    100 UG                                 | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Toxic Hepatopathy                    | 1  1  2  2  1     1  1  1  1  2  1     1        1     1     1  1  2     1|             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Fibrosis                  |             1                                                            |             
      Bile Duct, Hyperplasia               |    2  1           3        1     2                    1           1     1|             
      Centrilobular, Degeneration          |                                                                      3   |             
      Hepatocyte, Hypertrophy              |          1              1  1              2                       2      |             
      Hepatocyte, Multinucleated           |    1  1  1  1     2              2                                1  2   |             
      Oval Cell, Hyperplasia               |             2     2           1  1     1           2  1           1     1|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                      2   |             
      Fat, Necrosis                        |                               3                       2                  |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +           +           +  +  +     +  +              +        +         |             
      Gingival, Hyperplasia, Squamous      | 1           1              1        2  1              1        2         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       1                  |             
      Acinus, Atrophy                      |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                         3|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             3                                                            |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                         3|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                                         4|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         4|             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                         3|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +        +        +     +        +  +     +     +  +  +     +  +     +|             
      Peridontal Tissue, Inflammation      | 2  1        1        1     1        2  1     2     1  1  1     2  1     1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2|             
                                           | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    100 UG                                 | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1        1                 1  1     1           1  1        1  1  1  2|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2  1     1  1  1  2     1  1  2     2  1     2  2  2     1  2         |             
      Degeneration, Cystic                 | 2        3                    2                    2        1     4      |             
      Hyperplasia                          |    3        2     2  2     2  3  2           3  2              2         |             
      Hypertrophy                          | 3  2  1  4  2     1  2  2  1  4  1  1  1     2     2  2     3  2  1  2  1|             
      Vacuolization Cytoplasmic            | 2  1  1                                1                             1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  2     2                    3                 3           1         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3                 3     2                       2  2                 2|             
      Cytoplasmic Alteration               |                                                                          |             
      Pars Distalis, Hyperplasia           | 2        2     3  2     3        3  2  3        2           3  4  2     3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1     2  3  2  2        1     3           2     2     2  2            |             
      Follicular Cell, Hypertrophy         | 1  1  1  1  1  1  1  1     1  2  1  1  1  2        2     2  1     2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2|             
                                           | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    100 UG                                 | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 3  1  1  1  1  2  1  3     1     2  2  2  3  2  1  2  2  1  2  1     1   |             
      Duct, Cyst                           | 2  2  3  2  3  3  3  2  3  2  3  3  2  3  1  3     1  1     1  3  2  2  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4     4  4  4     4  4     4  4  4     4  4  4  4  4  4  4  4  4  4  4|             
      Cyst                                 | 2              2  2  2        2     2           3                 3     2|             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                   +                                                      |             
      Cyst                                 |                   3                                                      |             
      Inflammation, Chronic Active         |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                             2            |             
      Inflammation, Chronic Active         |                               3                                          |             
      Inflammation, Suppurative            |             3  2                                            1  2         |             
      Metaplasia, Squamous                 | 1        2  3  1  4  2  3     4  2  2     2     3  2  1  1  1  3  1  2   |             
      Endometrium, Hyperplasia, Cystic     | 3        4  3  2     2  1        2  2     2        2  3  1  3  3     1  3|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Hyperplasia                          | 2     4  2        3  2  3  3  3     3  3  3  3  3  2     3  2     4  4  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       1                                         2                       2|             
      Hyperplasia, Lymphoid                |          2                                2                              |             
      Hyperplasia, Plasma Cell             | 2  2        2  2  2  2  2  2     2  2  3     2     2  2  2  3  3  4  2  2|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2|             
                                           | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    100 UG                                 | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         |                                                                         4|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  3  2  1  2  2  2     3  2  2  2  3  2     2  1  1  3  2  1  2  3  3|             
      Hyperplasia                          |                                                                          |             
      Pigmentation                         | 2  2     1  2  1  1  2        1  2  1  1  2     2  2  1     2  2     1  1|             
      Lymphoid Follicle, Atrophy           |                         2                                                |             
      Red Pulp, Atrophy                    |                         2                                                |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
      Atrophy                              | 4  3  4  4  3     3  3  2  3  3  2     2           2  4  3  3     2  3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      2                                                   |             
      Hyperplasia                          | 1  1  3     2  1     3     2  1        2     1  1  2  1                  |             
      Inflammation, Granulomatous          |    3                 2                                            2      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                              2                           |             
      Ulcer                                |                                              2     2                     |             
      Dermis, Fibrosis                     |                   3                                                      |             
      Epidermis, Hyperplasia               |          4                                                               |             
      Subcutaneous Tissue, Inflammation    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2|             
                                           | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    100 UG                                 | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          2               |             
      Infiltration Cellular, Histiocyte    | 2  2  1  1  1  2  2  2  2  2  2  2  1  2        1  1  2     1  2  1  2  2|             
      Inflammation                         |                      2                                                   |             
      Metaplasia, Squamous                 |    1                                                                     |             
      Alveolar Epithelium, Hyperplasia     | 1  1        1     1  1     1     1                 1        1           2|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |    2  1        2        2     1        2              2           1  1   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1           1           1                 1               |             
      Olfactory Epithelium, Metaplasia     |                3                                                         |             
      Respiratory Epithelium, Hyperplasia  |                3                                                         |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |       2                                2                    2            |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  1           1        1     1        1           1        1         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                   1                                                      |             
      Mineralization                       |    1     1     1     1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1   |             
      Necrosis                             |                                                                          |             
      Nephropathy                          |    1  1  2  1  1  1  1        1  1  1              1  1     1  1        1|             
      Pigmentation                         |       1                                                           1      |             
      Pelvis, Inflammation                 |                                                                      1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 4| 7| 2| 7| 4| 7| 7| 4| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 2| 2| 0| 3| 9| 8| 1| 2| 6| 3| 5| 0| 6| 3| 3| 0| 3| 2| 6| 3| 2|             
                                           | 1| 0| 5| 0| 9| 9| 3| 0| 1| 8| 5| 9| 9| 0| 4| 5| 9| 0| 1| 7| 1| 9| 4| 1| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|             
    100 UG                                 | 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 2| 4| 5| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                  1                                       |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                           1        1     1               |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7|             
                             DAY ON TEST   | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2|             
                                           | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100 UG                                 | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |    X                                                                     |             
      Muscularis, Inflammation             |                                                                          |             
      Periesophageal Tissue, Inflammation  |    4                                                                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                              2                           |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                              2                           |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                            X  X           X     X                        |             
      Basophilic Focus, Multiple           |                                        X                                 |             
      Clear Cell Focus                     |                         X                                                |             
      Clear Cell Focus, Multiple           |                                     X                                    |             
      Eosinophilic Focus                   |          X                 X                 X                           |             
      Eosinophilic Focus, Multiple         |       X     X                 X  X     X  X     X  X     X  X  X  X     X|             
      Fatty Change, Diffuse                |    1        2                    2              3                       1|             
      Fatty Change, Focal                  |                   2                                         1            |             
      Hematopoietic Cell Proliferation     |       1     1  1                       1  1  1  1  1  2  1     1  2  2  1|             
      Hyperplasia, Nodular                 |                                              X                           |             
      Inflammation                         | 1  1  1  1  1     1     1  1  1  1  1  1  1  2     1  2  1     1  1  1  1|             
      Mixed Cell Focus                     |       X                                X                                 |             
      Mixed Cell Focus, Multiple           | X              X  X     X           X           X  X        X  X  X      |             
      Necrosis                             |             2                                3                           |             
      Pigmentation                         | 2        1        1     1  1  1  2     2  1        1  2     1  1     1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7|             
                             DAY ON TEST   | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2|             
                                           | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100 UG                                 | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Toxic Hepatopathy                    | 1        1  1     1                    1  1     1  1     1  1  1  1     1|             
      Bile Duct, Cyst                      |                                        2                                 |             
      Bile Duct, Fibrosis                  |                                           1                          1   |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Centrilobular, Degeneration          |             2                                                            |             
      Hepatocyte, Hypertrophy              |    1     2                    1  1     2  1     2        2        1     1|             
      Hepatocyte, Multinucleated           | 1                                      2  1                              |             
      Oval Cell, Hyperplasia               |             1     1                                         1     1     1|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +     +     +  +  +        +  +     +  +     +  +        +        +      |             
      Gingival, Hyperplasia, Squamous      | 1     1        2  2           1     1        2  2        1        2      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                           2                              |             
      Acinus, Atrophy                      |                                           2                              |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |             2     1                                                      |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                1  1                 1                                    |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +     +  +  +     +     +  +  +  +     +  +     +  +     +  +      |             
      Peridontal Tissue, Inflammation      | 1     1     1  1  2     1     1  1  1  1     2  1     1  1     1  1      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7|             
                             DAY ON TEST   | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2|             
                                           | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100 UG                                 | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1           1           1     1     1     1           1           1      |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2     2  2     2  1     2     2  2  2  1                 1        2  1  2|             
      Degeneration, Cystic                 |          1     3                                2  2        2     2     3|             
      Hyperplasia                          | 2     2     1     3     2     3           2  2  2     1                 2|             
      Hypertrophy                          | 1     1  4  2  3        2  1  2  1  2  1  3  2  3  4     1  2  2  1  3   |             
      Vacuolization Cytoplasmic            |             1     1           1        1           1  1           1      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3     2  2                 2  1              1              3  1|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2  3     2     3  3     3                                 |             
      Cytoplasmic Alteration               |          2                    2           2                              |             
      Pars Distalis, Hyperplasia           | 4     2                             2     2     2           2            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 4     3  2     1              3  2        2                 1           1|             
      Follicular Cell, Hypertrophy         | 1     1  2        2     1     2     1  1           1     3  2  1  2  1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7|             
                             DAY ON TEST   | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2|             
                                           | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100 UG                                 | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    3  1  1  2  2  2  1  2  1  2  1     2  2  1  2  2  3     1  2  2  2  2|             
      Duct, Cyst                           | 3     1     3  2  2  3  3  3  3  2     1  2  3  3  1  3  2  3  2  3  3  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  4     4  4     4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4|             
      Cyst                                 |          3  3                 2     2        2              2        2   |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                            1                       2                    2|             
      Metaplasia, Squamous                 |       2  2           1  1  3  2  4        2     2  3     1  3  2     1  2|             
      Endometrium, Hyperplasia, Cystic     | 2     2  2     2  1     2           4  3  2  2  1        3  3        2  2|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                  +                                       |             
      Inflammation                         |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                  3                                       |             
      Hyperplasia                          |    3  3  3  3  3  2  3     3  3        2  4  3  3  3  3  2  2  3  4  3  4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +                                            +                  |             
      Renal, Ectasia                       |          2                                                               |             
      Renal, Hemorrhage                    |          2                                                               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 1              2        2                                                |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Hyperplasia, Plasma Cell             | 2  3  2  2     3  2     2  3  3     3  2        2        3  2  3  2  2   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7|             
                             DAY ON TEST   | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2|             
                                           | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100 UG                                 | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         4|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2  2  3  3  1     2     2  1  2  2  2  3  2  2  3  2  2  3  3  3  3|             
      Hyperplasia                          |                                              2                           |             
      Pigmentation                         | 2  2     2  1  1  2     2  3  1     2  1  1  2  1  1  1  1  2  1     1  1|             
      Lymphoid Follicle, Atrophy           |                            2                                             |             
      Red Pulp, Atrophy                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  4  2  2  3  3  4     3  4  3  2     2  3  3  2  3  4  2  4  2  2  3  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       2                                                                  |             
      Hyperplasia                          |          1  1     1              2  2  2           1        1        1  2|             
      Inflammation, Granulomatous          |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
      Dermis, Fibrosis                     |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
      Subcutaneous Tissue, Inflammation    |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7|             
                             DAY ON TEST   | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2|             
                                           | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100 UG                                 | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1     1  2  2  2  2     2  1  1  2  1  1  1  2  1  2     2  2  2  2  1  2|             
      Inflammation                         |                                                                2         |             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                         2     1        1           1           1  1     1|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 1     1  1     2  2              1     1  1        1     1  2            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1                 2  2           1     1  1        1     1      |             
      Olfactory Epithelium, Metaplasia     |          2                    2                    2        1            |             
      Respiratory Epithelium, Hyperplasia  |          2                    2                 1  3        1     2      |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1        1              1        2  1              1               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |       1                                                                  |             
      Calculus Micro Observation Only      |       X                                                                  |             
      Cyst                                 |                                           2                              |             
      Infarct                              |                                     3                                    |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1  1  1  1  1  1        1  1     1  1  1  1        1  1     1     1  1  1|             
      Necrosis                             |                                                                         1|             
      Nephropathy                          | 1           1     1     1     1     2           1  1        1        1  1|             
      Pigmentation                         |                                                                          |             
      Pelvis, Inflammation                 |                                     2        3     1                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 1| 6| 6| 7| 6| 6| 4| 7| 6| 7| 7| 7| 7| 5| 6| 5| 6| 4| 5| 7| 4| 6| 4| 7|             
                             DAY ON TEST   | 2| 2| 0| 3| 2| 5| 5| 3| 2| 3| 1| 3| 2| 2| 8| 6| 8| 5| 5| 5| 3| 6| 5| 9| 2|             
                                           | 9| 5| 3| 6| 2| 9| 4| 3| 9| 8| 5| 1| 9| 9| 9| 4| 1| 4| 8| 6| 1| 1| 4| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 NG /                               | 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100 UG                                 | 2| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Renal Tubule, Degeneration           |                                  3                                       |             
      Transitional Epithelium, Hyperplasia |                                     1        3                           |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                        1     2                           |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 3|                                                                 |            |
                                           | 9| 0| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100 NG /                               | 9| 9| 9|                                                                 |      L     |
    100 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  52        |
      Perforation                          |                                                                          |      1     |
      Muscularis, Inflammation             |                                                                          |      1  2.0|
      Periesophageal Tissue, Inflammation  |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                          |      8     |
      Basophilic Focus, Multiple           | X                                                                        |      6     |
      Clear Cell Focus                     |                                                                          |      2     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      4     |
      Eosinophilic Focus, Multiple         | X  X  X                                                                  |     26     |
      Fatty Change, Diffuse                | 1                                                                        |      9  1.7|
      Fatty Change, Focal                  |    1                                                                     |      7  1.1|
      Hematopoietic Cell Proliferation     | 1     1                                                                  |     30  1.1|
      Hyperplasia, Nodular                 |                                                                          |      2     |
      Inflammation                         | 1  1  2                                                                  |     46  1.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 3|                                                                 |            |
                                           | 9| 0| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100 NG /                               | 9| 9| 9|                                                                 |      L     |
    100 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Mixed Cell Focus                     |                                                                          |      4     |
      Mixed Cell Focus, Multiple           | X     X                                                                  |     26     |
      Necrosis                             |                                                                          |      5  2.0|
      Pigmentation                         | 2  2  2                                                                  |     38  1.3|
      Toxic Hepatopathy                    | 3  1  1                                                                  |     34  1.2|
      Bile Duct, Cyst                      |                                                                          |      1  2.0|
      Bile Duct, Fibrosis                  |                                                                          |      3  1.0|
      Bile Duct, Hyperplasia               | 2                                                                        |      9  1.6|
      Centrilobular, Degeneration          |                                                                          |      2  2.5|
      Hepatocyte, Hypertrophy              | 1  2                                                                     |     17  1.4|
      Hepatocyte, Multinucleated           | 2  1  1                                                                  |     14  1.4|
      Oval Cell, Hyperplasia               | 2                                                                        |     15  1.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +                                                                  |  46        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +  +  +                                                                  |  25        |
      Gingival, Hyperplasia, Squamous      |       4                                                                  |     18  1.6|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Inflammation, Chronic Active         |       1                                                                  |      3  1.3|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  52        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      2  1.5|
      Inflammation                         |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 3|                                                                 |            |
                                           | 9| 0| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100 NG /                               | 9| 9| 9|                                                                 |      L     |
    100 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Stomach, Glandular                      | +  +  +                                                                  |  52        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      3  1.0|
      Ulcer                                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +  +                                                                  |  33        |
      Peridontal Tissue, Inflammation      | 1  1  2                                                                  |     33  1.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Cardiomyopathy                       |    1  1                                                                  |     22  1.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  52        |
      Angiectasis                          | 2  2  2                                                                  |     33  1.6|
      Degeneration, Cystic                 |                                                                          |     13  2.2|
      Hyperplasia                          | 3  3                                                                     |     23  2.2|
      Hypertrophy                          | 3  2  1                                                                  |     44  2.0|
      Vacuolization Cytoplasmic            | 2  2                                                                     |     14  1.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Hyperplasia                          |                                                                          |     14  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  46        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 3|                                                                 |            |
                                           | 9| 0| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100 NG /                               | 9| 9| 9|                                                                 |      L     |
    100 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          | 3  1  3                                                                  |     15  2.5|
      Cytoplasmic Alteration               |                                                                          |      3  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |     19  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      C-Cell, Hyperplasia                  |    2  3                                                                  |     22  2.1|
      Follicular Cell, Hypertrophy         | 1                                                                        |     34  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         | 2  2  1                                                                  |     46  1.7|
      Duct, Cyst                           | 3  3  2                                                                  |     48  2.4|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  52        |
      Atrophy                              | 4  4  4                                                                  |     45  4.0|
      Cyst                                 |    2                                                                     |     17  2.2|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Adenomyosis                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |    1                                                                     |      8  1.8|
      Metaplasia, Squamous                 | 3                                                                        |     35  2.1|
      Endometrium, Hyperplasia, Cystic     | 3  1  4                                                                  |     34  2.3|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 3|                                                                 |            |
                                           | 9| 0| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100 NG /                               | 9| 9| 9|                                                                 |      L     |
    100 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Degeneration                         |                                                                          |      1  3.0|
      Hyperplasia                          | 2  2                                                                     |     42  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Renal, Ectasia                       |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  52        |
      Ectasia                              |                                                                          |      6  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Hyperplasia, Plasma Cell             | 2  3  3                                                                  |     40  2.4|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
      Hematopoietic Cell Proliferation     | 2  2  2                                                                  |     49  2.2|
      Hyperplasia                          |                                                                          |      1  2.0|
      Pigmentation                         | 2  2  2                                                                  |     43  1.5|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  2.0|
      Red Pulp, Atrophy                    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  48        |
      Atrophy                              | 2     2                                                                  |     43  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 3|                                                                 |            |
                                           | 9| 0| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100 NG /                               | 9| 9| 9|                                                                 |      L     |
    100 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Cyst                                 |                                                                          |      2  2.0|
      Hyperplasia                          | 1  2                                                                     |     25  1.5|
      Inflammation, Granulomatous          |                                                                          |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  2.0|
      Dermis, Fibrosis                     |                                                                          |      1  3.0|
      Epidermis, Hyperplasia               |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  52        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 1  2  2                                                                  |     47  1.6|
      Inflammation                         |                                                                          |      2  2.0|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |     17  1.1|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 1  2  1                                                                  |     23  1.4|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         | 1                                                                        |     13  1.2|
      Olfactory Epithelium, Metaplasia     |                                                                          |      5  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 3|                                                                 |            |
                                           | 9| 0| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    100 NG /                               | 9| 9| 9|                                                                 |      L     |
    100 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Respiratory Epithelium, Hyperplasia  |                                                                          |      7  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Retina, Atrophy                      |                                                                          |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |       1                                                                  |     16  1.1|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  52        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  1.0|
      Calculus Micro Observation Only      |                                                                          |      1     |
      Cyst                                 |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mineralization                       | 1  1                                                                     |     39  1.0|
      Necrosis                             |                                                                          |      1  1.0|
      Nephropathy                          | 1  1  2                                                                  |     29  1.1|
      Pigmentation                         |       1                                                                  |      3  1.0|
      Pelvis, Inflammation                 |                                                                          |      4  1.8|
      Renal Tubule, Degeneration           |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia | 2                                                                        |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      5  1.2|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1|             
                                           | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    300 UG                                 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                         2                 1        1                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    3                             4                                       |             
      Ulcer                                |          4                                                               |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       X                                                                  |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cholangiofibrosis                    | 1        2                       1                                   2   |             
      Clear Cell Focus                     |                                                                      X   |             
      Eosinophilic Focus                   |    X        X     X           X                                         X|             
      Eosinophilic Focus, Multiple         | X     X  X     X     X  X  X     X  X     X  X  X  X  X  X     X  X  X   |             
      Fatty Change, Diffuse                |    3  2     1  1     2  3  3  2  2           1  1  2     1     1     1  1|             
      Fatty Change, Focal                  |                                                    2                     |             
      Hematopoietic Cell Proliferation     | 1                    1  1     2           1  1     1  1  1  1  1         |             
      Hyperplasia, Nodular                 | X     X  X     X                       X     X  X     X  X  X  X     X   |             
      Inflammation                         | 1  1  2  2  2  1  2  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1   |             
      Mixed Cell Focus                     |                                                                      X   |             
      Mixed Cell Focus, Multiple           | X     X        X  X     X        X  X  X     X        X  X     X         |             
      Necrosis                             |       1                                                                  |             
      Pigmentation                         | 2  1  2  3  2  2  2  2  1  1  1  2  2  2  2  2  2  1  2  2  4  2  1  2  2|             
      Toxic Hepatopathy                    | 2  1  3  2  2  3  2  2  2  2  2  3  1  2  1  2  2  1  2  2  3  3     3  2|             
      Bile Duct, Cyst                      |                4                                                        2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1|             
                                           | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    300 UG                                 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |          1                                                               |             
      Bile Duct, Hyperplasia               | 1     1  2     2                 1  1           1           1  1     1   |             
      Centrilobular, Degeneration          |                      2                 1           1                     |             
      Centrilobular, Fibrosis              |                                                             1            |             
      Hepatocyte, Hypertrophy              | 2  2  2  3  2  2  1     2  3  1  3              3     1  1  3        3  3|             
      Hepatocyte, Multinucleated           | 1     2  2  1  1  2  2  1  1  2  2  2  1  1  1  2  1  1  2  2  1     1  2|             
      Oval Cell, Hyperplasia               | 2     1  3     1     1  1  1     2     1     1  1  1  1  1  3  1     3  1|             
      Portal, Fibrosis                     |                                                             1        2   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                         3                                                |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +  +     +  +     +  +  +     +  +     +           +  +     +  +|             
      Gingival, Hyperplasia, Squamous      |             2        2        1        2  1     2              3     1   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                                                    1                 1   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |          2                                                              2|             
      Hyperplasia, Squamous                |          3                                   2                          2|             
      Inflammation                         |                                                 2                        |             
      Ulcer                                |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                  4                                       |             
      Erosion                              |                                  2                                       |             
      Mineralization                       |                            2                                             |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +        +  +  +  +  +     +  +     +  +     +     +     +  +     +  +|             
      Peridontal Tissue, Inflammation      |    1        2  1  1  1  1     1  1     3  2     2     1     2  2     1  3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1|             
                                           | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    300 UG                                 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                         3|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1           1           1  1     1     1  1  1  1  1     1        1|             
      Pericardium, Necrosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1     2  2     2  2        2  2  2  2     2  1           1        2|             
      Atrophy                              |                   2        3                                             |             
      Degeneration, Cystic                 |       1           1  2     2        1        3           2              2|             
      Hyperplasia                          | 2     2           3              3     3        2  4  2  2  2     2     2|             
      Hypertrophy                          | 3     3  2  3  2  2  3           1  4  2  1  4     2  4  3  2  2     3  3|             
      Vacuolization Cytoplasmic            |    1  1           2                 1              2  2                 1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             3  4                             2              1            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2  1                             2     2              2           2|             
      Inflammation                         |                                                                          |             
      Vacuolization Cytoplasmic            |             2                                                            |             
      Pars Distalis, Hyperplasia           | 2        2  3  1           2     3     3     4     2  1  3  2  2        3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                3  2  2           2           3     2                     |             
      Follicular Cell, Hypertrophy         | 1  1  3  2  1     1           1  1  1  1  1  2     1  1  2        2  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1|             
                                           | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    300 UG                                 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  4  1  1  1  1  1  1  1  1  2  2  1     3  1  1  2  2  1  1     2  1|             
      Duct, Cyst                           | 3  1  3  3  2  3  2  3  2  1     3  3  2     2  2  2  2  2  1  2  3  2  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4     4     4  4  4     4     4  4     4  4  4  4  4  4  4|             
      Cyst                                 |    2        3                    3     2                       1     2   |             
      Inflammation, Suppurative            | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                            +                                             |             
      Cyst                                 |                            2                                             |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |       2           2              2                          2            |             
      Metaplasia, Squamous                 | 2  2  3     3  2  4  1     4  3  3     1     4        2     3  1  2  3  3|             
      Endometrium, Hyperplasia, Cystic     | 1  2        3  2                 2     1              4  3     2  2  3   |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  2  4     2  2  3  2  2  4  2  3  2  4  3  2  3  3  3  1  2  2  3  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +                                                                 +   |             
      Angiectasis                          |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Lumbar, Ectasia                      |                                                                          |             
      Mediastinal, Hemorrhage              |    2                                                                     |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Pancreatic, Hyperplasia, Histiocytic |                                                                      2   |             
      Pancreatic, Pigmentation             |                                                                      2   |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1|             
                                           | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    300 UG                                 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                                                    2                     |             
      Hyperplasia, Lymphoid                |                                     2                             2      |             
      Hyperplasia, Plasma Cell             | 2     3     2  3  2  2     2  2  2     2  2     3  2  3  3  2  3  2  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             2            |             
      Hyperplasia, Histiocytic             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 3                                                                        |             
      Hematopoietic Cell Proliferation     | 2  1  1     1  1  2  2  2  1  3  2  3  1  2  2     3  2  2  2  2     2   |             
      Pigmentation                         | 2  2  2  2  2  2  1  1  1  1  1  1  1  2  1  1  2  1  2  2  2  2  2  2  3|             
      Lymphoid Follicle, Atrophy           |                                                 3                       2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  4  3  3  4  4  4  4     4     4  2  4  4  4  3  4  4  4     4  4|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                   2      |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                                                                    2   |             
      Hyperplasia                          | 1     1     1        2  2           3        2  2  2  1        1        2|             
      Inflammation, Granulomatous          |                                                                         2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1|             
                                           | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    300 UG                                 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2     2  2  2  2  2  1  1  2     1  1  2  2  2  2  1  3  2  1  2     2  2|             
      Inflammation                         |    2                 3                                                   |             
      Metaplasia, Squamous                 |                   2                                                      |             
      Mineralization                       |                                                                         2|             
      Alveolar Epithelium, Hyperplasia     | 1                    1                                                  2|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 2     2  1  2  2  2              1  2  1  2  2     1  3  2  1  2     1  1|             
      Mediastinum, Necrosis                |                                                                          |             
      Serosa, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2                    2     1                 2     2     1               |             
      Olfactory Epithelium, Metaplasia     |                      2                       2     2                     |             
      Respiratory Epithelium, Hyperplasia  | 2                          2                 2     1     2               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Ciliary Body,      |                                                                          |             
          Cornea, Inflammation             |                                                                          |             
      Cornea, Inflammation                 |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  1           1                    1     1        2  2               |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 6| 7| 7| 7| 6| 4| 5| 4| 7| 5| 7| 5| 6| 7| 6| 7| 7| 6| 7| 3| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 1| 3| 2| 3| 5| 9| 3| 5| 2| 0| 2| 5| 6| 1| 0| 3| 3| 0| 3| 6| 2| 1|             
                                           | 9| 0| 0| 2| 0| 9| 0| 4| 9| 9| 1| 9| 5| 9| 6| 5| 0| 3| 0| 1| 3| 1| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    300 UG                                 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Calculus Micro Observation Only      |                         X  X                                             |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                1                                                         |             
      Mineralization                       | 1     1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1  2|             
      Nephropathy                          | 2     2     1  1  1        1           2     1     1  1  1     1     1  3|             
      Pigmentation                         |                               1  2                                   1   |             
      Pelvis, Dilatation                   |                                                                         2|             
      Pelvis, Inflammation                 |                   3     2        2                                       |             
      Renal Tubule, Degeneration           |                      2                                   2               |             
      Transitional Epithelium, Hyperplasia | 1     2           4        1           3     2                           |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   3     1              1                                 |             
      Transitional Epithelium, Hyperplasia |                   2                                                      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3|             
                                           | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    300 UG                                 | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                              |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                 2                                    |             
      Basophilic Focus                     |                                        X                                 |             
      Basophilic Focus, Multiple           |                                           X                              |             
      Cholangiofibrosis                    |                2              4           2                              |             
      Clear Cell Focus                     |                               X                                         X|             
      Eosinophilic Focus                   |          X                                                               |             
      Eosinophilic Focus, Multiple         |       X     X     X           X  X  X  X  X  X     X  X        X  X  X   |             
      Fatty Change, Diffuse                | 2     1  1           1  1              2              3  1  1  1     1  1|             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                               1     1        1  2     1  1              1|             
      Hyperplasia, Nodular                 | X     X        X        X     X  X        X  X              X        X  X|             
      Inflammation                         | 1  1  2  2  1  1  1  2  1     1  1     1  2  1     2  1  1  1  2  1     1|             
      Mixed Cell Focus                     |                                                    X                     |             
      Mixed Cell Focus, Multiple           |       X        X  X  X  X     X  X     X                    X  X     X  X|             
      Necrosis                             |                                              1                    1  1   |             
      Pigmentation                         | 2  2  3  1  2  2  1  2  2     2  2  2  2  2  2     3  1     2  2  2  2  2|             
      Toxic Hepatopathy                    | 2     2  2  1  2  2  3  2     3  3  1  3  3  2     2  2     1  1  2  2  2|             
      Bile Duct, Cyst                      |                2  2              2                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3|             
                                           | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    300 UG                                 | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |                                        1                          1      |             
      Bile Duct, Hyperplasia               |       1  1     1  1  1  1     2  2  1  3  2  1     2  1     2     1  2   |             
      Centrilobular, Degeneration          |                                              2                           |             
      Centrilobular, Fibrosis              |                                                                          |             
      Hepatocyte, Hypertrophy              |    1     3  3                 3     2     3  1     2  1  1  1  2        2|             
      Hepatocyte, Multinucleated           | 2  2  2     2  1  1  1        2  2  1  1  2  2     2  2     2  2  2  2  2|             
      Oval Cell, Hyperplasia               |       1  1  1  1  1  1  2     3  2  1  2  3  2     2        2  1  2  2  2|             
      Portal, Fibrosis                     |                               2  2     1                             1  1|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                    3                 2   |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +        +  +        +  +        +     +  +  +     +        +  +     +  +|             
      Gingival, Hyperplasia, Squamous      | 1        2  2           2        1     1  1  1     3        3  1     1  1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        1                                 |             
      Acinus, Atrophy                      |                                        1                                 |             
      Acinus, Hyperplasia                  |                      3                                                   |             
      Acinus, Vacuolization Cytoplasmic    |                               1  1     1     1                          1|             
      Artery, Inflammation, Chronic Active |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |             2     2                                   2                  |             
      Inflammation                         |                                                                          |             
      Ulcer                                |             3                                                            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Erosion                              |                                                                          |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |          +  +  +     +  +        +  +  +  +  +     +     +     +  +  +  +|             
      Peridontal Tissue, Inflammation      |          2  2  1     3  2        1  1  1  1  1     3     1     1  1  1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3|             
                                           | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    300 UG                                 | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1  2  1     1  1  1  1  1     1           1        1  1        1|             
      Pericardium, Necrosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1     1     3     2  1           3  2                 2        1         |             
      Atrophy                              |                                                                         4|             
      Degeneration, Cystic                 |             2  2        2        3  1  1                                 |             
      Hyperplasia                          |          1     2  3  3  2           4  2           3  3  3           3   |             
      Hypertrophy                          | 1     2  1  3  4  3  2  3     2  3     2  2  1     3  2     2  2  3  2  1|             
      Vacuolization Cytoplasmic            |                                     1                                    |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2        1     2  2     1  2                             3         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          3     2        2     2  2  3     2        2           1     2   |             
      Inflammation                         |                2                                                         |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           |                3     3           3                    2           2      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1     2                 3  2  2                          3|             
      Follicular Cell, Hypertrophy         |       1  2     1  2  1  2        1  1     3     3  2     2  2  1     1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3|             
                                           | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    300 UG                                 | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1     1     3              1  1  2     2  2     1  1  1     2  1     1|             
      Duct, Cyst                           |    2           2  3  2  2     2  2  2  2  3  2        2  1     3  3  2  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4     4     4  4     4  4  4  4  4  4     4  3  4  4  4     4  4|             
      Cyst                                 |       3              3  2                 2        4  2     4        3   |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                     +                                    |             
      Cyst                                 |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2                          3     1     4        2              3      |             
      Inflammation, Suppurative            | 1                    1                       1              2  1         |             
      Metaplasia, Squamous                 | 4  4  2        1     1  4     4  2  4     3  4     4        4  4  3  4  4|             
      Endometrium, Hyperplasia, Cystic     |       2        2     2           2              1                        |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2     4  3     4  2     3  3  2  3  3  3  4  3  4  3  3  3  2  4  3   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +     +                          +                           |             
      Angiectasis                          |                   2                                                      |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Lumbar, Ectasia                      |                                              2                           |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |             2                                                            |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3|             
                                           | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    300 UG                                 | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mandibular                  | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Congestion                           |    3                                                                     |             
      Ectasia                              |                                        2                                1|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 3     2        2  2  3  3     3  3  2  2           3  2     1  2     3   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 1  1  2  2     2  2  2  2     2  2  2  2  3  3  3  3  2  2  2  2  3  2  2|             
      Pigmentation                         | 2  2  2  1  3  3  1  3  2     2  2  2  2  1  1     1  1  1  2  2  1  3  3|             
      Lymphoid Follicle, Atrophy           |    2        3                                                            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|             
      Atrophy                              | 4     4     4  4  4  4  4     4  4     4  4  3     4  4     4  4     4  4|             
      Cyst                                 |                                                    3                     |             
      Hemorrhage                           |    3                       2                                             |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 1           2  1  1           1        1           1  1        1         |             
      Inflammation, Granulomatous          |                         2                                                |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3|             
                                           | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    300 UG                                 | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1     2  2  1  3  2  2  2     2  1  1  2  2        2  2  2  2  2  1  1  2|             
      Inflammation                         |                                  1                          1            |             
      Metaplasia, Squamous                 |                   1                                                      |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                       2     1            |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |       2     1  2  2  2  2     2  1  1  3  2        2           2     1  2|             
      Mediastinum, Necrosis                |                                                                          |             
      Serosa, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             2  1                    1  2  2  1                       2   |             
      Olfactory Epithelium, Metaplasia     |                                     2     3                          2   |             
      Respiratory Epithelium, Hyperplasia  |             2                       2     3  2                    2  3   |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |             +                                                            |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Ciliary Body,      |                                                                          |             
          Cornea, Inflammation             | 3                                                                        |             
      Cornea, Inflammation                 |                                                                          |             
      Retina, Atrophy                      |                   2                                                     2|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 3                 1              1                                   1  1|             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                        +                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 3| 7| 5| 6| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 5| 1| 7| 5| 2| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 1| 2| 8| 1| 3| 3| 3| 2| 9| 3| 3| 5| 2| 1| 5| 4| 2| 0| 5| 3| 3| 8| 2| 3|             
                                           | 0| 0| 9| 3| 8| 0| 1| 0| 9| 6| 0| 0| 9| 9| 5| 2| 2| 9| 5| 4| 1| 1| 4| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    300 NG /                               | 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    300 UG                                 | 2| 3| 5| 6| 7| 0| 1| 2| 5| 6| 6| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                 2                        |             
      Calculus Micro Observation Only      | X                                                                 X      |             
      Cyst                                 |             3                                                            |             
      Inflammation, Chronic Active         |             3                                                            |             
      Inflammation, Suppurative            |                      1                 1     1                 1         |             
      Mineralization                       | 1  1  1        1     1  1        1  1  1  1  1     1  1  1     1  1  1  1|             
      Nephropathy                          | 2     1  1     1  1  2  1     2  2     1     1  1  1     1  1  1     2  1|             
      Pigmentation                         |                               1        2                             1  1|             
      Pelvis, Dilatation                   |             3                                                            |             
      Pelvis, Inflammation                 |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
      Transitional Epithelium, Hyperplasia |          1           2        2              2     1                     |             
                                           |__________________________________________________________________________|             
   Ureter                                  |             +                                                            |             
      Inflammation                         |             2                                                            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             2           1                    1     1                     |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4|                                                                 |            |
                             DAY ON TEST   | 5| 0| 7|                                                                 |            |
                                           | 0| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    300 NG /                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.5|
      Ulcer                                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     |                                                                          |      2     |
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Cholangiofibrosis                    |                                                                          |      7  2.0|
      Clear Cell Focus                     |                                                                          |      3     |
      Eosinophilic Focus                   |       X                                                                  |      7     |
      Eosinophilic Focus, Multiple         | X                                                                        |     33     |
      Fatty Change, Diffuse                | 1  1  2                                                                  |     31  1.5|
      Fatty Change, Focal                  |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |       1                                                                  |     19  1.1|
      Hyperplasia, Nodular                 | X                                                                        |     24     |
      Inflammation                         | 1  1  1                                                                  |     48  1.2|
      Mixed Cell Focus                     |                                                                          |      2     |
      Mixed Cell Focus, Multiple           |                                                                          |     24     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4|                                                                 |            |
                             DAY ON TEST   | 5| 0| 7|                                                                 |            |
                                           | 0| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    300 NG /                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Necrosis                             |                                                                          |      4  1.0|
      Pigmentation                         | 2  2  2                                                                  |     50  1.9|
      Toxic Hepatopathy                    | 2  1  1                                                                  |     48  2.0|
      Bile Duct, Cyst                      |                                                                          |      5  2.4|
      Bile Duct, Fibrosis                  |    1                                                                     |      4  1.0|
      Bile Duct, Hyperplasia               | 1  2                                                                     |     29  1.4|
      Centrilobular, Degeneration          |                                                                          |      4  1.5|
      Centrilobular, Fibrosis              |                                                                          |      1  1.0|
      Hepatocyte, Hypertrophy              | 2  2  2                                                                  |     33  2.1|
      Hepatocyte, Multinucleated           | 2  2  1                                                                  |     46  1.6|
      Oval Cell, Hyperplasia               | 2  1                                                                     |     39  1.6|
      Portal, Fibrosis                     |                                                                          |      7  1.4|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +                                                                  |  47        |
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.5|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +     +                                                                  |  30        |
      Gingival, Hyperplasia, Squamous      | 2                                                                        |     22  1.6|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Acinus, Hyperplasia                  |                                                                          |      1  3.0|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      7  1.0|
      Artery, Inflammation, Chronic Active |    2                                                                     |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  52        |
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Hyperplasia, Squamous                |       1                                                                  |      7  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4|                                                                 |            |
                             DAY ON TEST   | 5| 0| 7|                                                                 |            |
                                           | 0| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    300 NG /                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  52        |
      Ectopic Tissue                       |                                                                          |      1  4.0|
      Erosion                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +  +                                                                  |  35        |
      Peridontal Tissue, Inflammation      | 2  1  1                                                                  |     35  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |    2                                                                     |     26  1.1|
      Pericardium, Necrosis                |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  52        |
      Angiectasis                          |    1                                                                     |     23  1.7|
      Atrophy                              |                                                                          |      3  3.0|
      Degeneration, Cystic                 |                                                                          |     14  1.8|
      Hyperplasia                          | 3  3                                                                     |     25  2.6|
      Hypertrophy                          | 2     1                                                                  |     41  2.3|
      Vacuolization Cytoplasmic            | 2  1                                                                     |     10  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Hyperplasia                          |    2  2                                                                  |     13  2.1|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4|                                                                 |            |
                             DAY ON TEST   | 5| 0| 7|                                                                 |            |
                                           | 0| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    300 NG /                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Angiectasis                          |    2                                                                     |     17  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           | 3                                                                        |     20  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      C-Cell, Hyperplasia                  |                                                                          |     12  2.3|
      Follicular Cell, Hypertrophy         |    2  1                                                                  |     35  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         | 1     2                                                                  |     40  1.4|
      Duct, Cyst                           | 3  3  3                                                                  |     43  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  52        |
      Atrophy                              | 4  4  4                                                                  |     43  4.0|
      Cyst                                 |                                                                          |     14  2.6|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   2        |
      Cyst                                 |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  52        |
      Inflammation, Chronic Active         | 3                                                                        |      7  2.6|
      Inflammation, Suppurative            |    2                                                                     |     10  1.6|
      Metaplasia, Squamous                 | 3                                                                        |     36  2.9|
      Endometrium, Hyperplasia, Cystic     | 4     1                                                                  |     18  2.2|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4|                                                                 |            |
                             DAY ON TEST   | 5| 0| 7|                                                                 |            |
                                           | 0| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    300 NG /                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 3  4  3                                                                  |     48  2.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +  +                                                                  |   7        |
      Angiectasis                          |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Plasma Cell   |    2                                                                     |      1  2.0|
      Lumbar, Ectasia                      |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Histiocytic|    2                                                                     |      1  2.0|
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |      1  2.0|
      Pancreatic, Pigmentation             |                                                                          |      1  2.0|
      Renal, Ectasia                       |    2                                                                     |      1  2.0|
      Renal, Hyperplasia, Histiocytic      |    2                                                                     |      1  2.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  50        |
      Congestion                           |                                                                          |      1  3.0|
      Ectasia                              |                                                                          |      3  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             |    3  3                                                                  |     36  2.4|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 2  2  3                                                                  |     47  2.0|
      Pigmentation                         | 1  1  1                                                                  |     51  1.7|
      Lymphoid Follicle, Atrophy           |                                                                          |      4  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4|                                                                 |            |
                             DAY ON TEST   | 5| 0| 7|                                                                 |            |
                                           | 0| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    300 NG /                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  50        |
      Atrophy                              | 4  2  3                                                                  |     42  3.8|
      Cyst                                 |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      3  2.3|
      Epithelial Cell, Hyperplasia         |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |    3                                                                     |      3  2.3|
      Hyperplasia                          | 1                                                                        |     22  1.4|
      Inflammation, Granulomatous          | 1                                                                        |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  52        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 1  2  1                                                                  |     46  1.7|
      Inflammation                         |                                                                          |      4  1.8|
      Metaplasia, Squamous                 |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4|                                                                 |            |
                             DAY ON TEST   | 5| 0| 7|                                                                 |            |
                                           | 0| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    300 NG /                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      5  1.4|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |    1                                                                     |     34  1.7|
      Mediastinum, Necrosis                |       3                                                                  |      1  3.0|
      Serosa, Inflammation                 |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |     13  1.6|
      Olfactory Epithelium, Metaplasia     |                                                                          |      6  2.2|
      Respiratory Epithelium, Hyperplasia  |                                                                          |     11  2.1|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  52        |
      Anterior Chamber, Ciliary Body,      |                                                                          |            |
          Cornea, Inflammation             |                                                                          |      1  3.0|
      Cornea, Inflammation                 |    3                                                                     |      1  3.0|
      Retina, Atrophy                      |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  52        |
      Inflammation                         |       1                                                                  |     14  1.3|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  52        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  2.0|
      Calculus Micro Observation Only      |                                                                          |      4     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4|                                                                 |            |
                             DAY ON TEST   | 5| 0| 7|                                                                 |            |
                                           | 0| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    300 NG /                               | 9| 9| 9|                                                                 |      L     |
    300 UG                                 | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      5  1.0|
      Mineralization                       |    1  1                                                                  |     42  1.0|
      Nephropathy                          |    2  1                                                                  |     34  1.3|
      Pigmentation                         |                                                                          |      7  1.3|
      Pelvis, Dilatation                   |                                                                          |      2  2.5|
      Pelvis, Inflammation                 |                                                                          |      3  2.3|
      Renal Tubule, Degeneration           |                                                                          |      2  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |     11  1.9|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      7  1.4|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4|             
                             DAY ON TEST   | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7|             
                                           | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5|             
    1000 UG                                | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           3                              |             
      Perforation                          |                                        X                                 |             
      Muscularis, Inflammation             |                                        3        1  2                     |             
      Periesophageal Tissue, Hemorrhage    |                                                                          |             
      Periesophageal Tissue, Inflammation  |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                 3                        |             
      Parasite Metazoan                    |                                                                X         |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                3                        |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cholangiofibrosis                    | 3     4  4  3  4  3  4  4  4  3     4     2  4  4  3  3  3  3  4  4      |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                  X                                       |             
      Eosinophilic Focus, Multiple         | X  X  X                 X                                         X      |             
      Fatty Change, Diffuse                |    2  2  2  2  1  1     1     2     2     1  2  2  2  2  1     2  2  1  1|             
      Fatty Change, Focal                  | 2        2                 2                                      2      |             
      Hematopoietic Cell Proliferation     |                            1     1              1                        |             
      Hyperplasia, Nodular                 | X  X  X  X  X  X  X  X  X  X  X     X     X  X  X  X  X  X  X  X  X     X|             
      Inflammation                         | 1  1     1  2  2  1  1  2  2  2  3  3     1  1  1  1  1  1  2  2     1  1|             
      Metaplasia                           |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4|             
                             DAY ON TEST   | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7|             
                                           | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5|             
    1000 UG                                | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Mixed Cell Focus, Multiple           |                                                 X                        |             
      Necrosis                             |             2  2     3  2  2  3  2                       2     3        2|             
      Pigmentation                         | 1  3  2  2  3  2  2  2  2  2  2  1  1     1  2  3  2  2  3  2  1  2  2  3|             
      Toxic Hepatopathy                    | 4  3  4  4  4  4  4  4  3  4  4  2  4     4  4  4  4  4  4  4  4  4  2  2|             
      Bile Duct, Cyst                      | 2     2        3     3        4     3        2     2        2  2  3      |             
      Bile Duct, Hyperplasia               | 1  3  3  2  3  2  2  3  2  2  2     3     2  3  2  2  2  2  2  3  3     1|             
      Centrilobular, Degeneration          |                                                                         3|             
      Centrilobular, Fibrosis              |                                                                          |             
      Hepatocyte, Hypertrophy              | 4  3  3  3  3  3  4  4  3  4  3  3  4     4  4  3  3  4  3  3  4  3  3  2|             
      Hepatocyte, Multinucleated           | 1  3  3  2  2  1  3  2  3  1  1  2  1     2  2  1  2  2  3  1     2  3  2|             
      Oval Cell, Hyperplasia               | 3  2  3  3  4  3  3  4  3  3  3     4     3  3  3  2  3  3  3  4  3     2|             
      Portal, Fibrosis                     | 2  2  2  2  2     2  2  2  2        2     3  3  3     2  2  2  3         |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  M|             
      Artery, Inflammation, Chronic Active |                            1                                             |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +  +  +  +  +  +  +  +     +     +  +        +  +  +     +      |             
      Gingival, Hyperplasia, Squamous      | 1        1  2        1  2  2  1     3     1  2              2     2      |             
      Pharyngeal, Inflammation             |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |    1        2     2                 1                                    |             
      Acinus, Vacuolization Cytoplasmic    | 2     2  2  2  2  2  2     2  2     2     1  3  2  1  2  2  1  2  2      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |             1                 2              2                           |             
      Ulcer                                |                                                          2               |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            1                                             |             
      Erosion                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +  +  +        +     +     +  +     +  +     +        +     +  +   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4|             
                             DAY ON TEST   | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7|             
                                           | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5|             
    1000 UG                                | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Peridontal Tissue, Inflammation      | 1     2  1  2        1     1     1  2     2  2     1        1     2  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1  1           1                                      1     1  1   |             
      Fibrosis                             |                                                                          |             
      Hemorrhage                           |                                        3                                 |             
      Inflammation, Chronic Active         |                                        3                                 |             
      Thrombosis                           |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                            1                                      2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Atrophy                              | 3  2  2  4  2  3     3        4           4  2  2     4  2  2  2  2      |             
      Degeneration, Cystic                 | 3           2  2     2                             1  1           1     1|             
      Hyperplasia                          | 3              2                                3        2     2        2|             
      Hypertrophy                          | 1     1  3  4  1     3  2  1  3              2     3  3  2  1  1  3  1   |             
      Necrosis                             |                                                                         2|             
      Vacuolization Cytoplasmic            | 2        2  2                 2              2     1                     |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      1   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Hyperplasia           | 1     3     3  3                             2  2        2  1  2         |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4|             
                             DAY ON TEST   | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7|             
                                           | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5|             
    1000 UG                                | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1        2  1           2                          2        2  2     1   |             
      Follicular Cell, Hypertrophy         | 2  2  3  2  2  1  2     2  2  3  1  1        2  2  2  2     2  2  3      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1           1           1              1     1     1  1  1        1   |             
      Duct, Cyst                           | 2  3  3  3  2  2  3  1  2  2  1     2        2  2  2  2  3  3     3  3  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3        4  4        3  4                 4  4        4            |             
      Cyst                                 |                3     3              2                    2              3|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                            3                                             |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                         1  4                    1                        |             
      Metaplasia, Squamous                 |       4        1           3  2                 2  4        3           1|             
      Ulcer                                |                            3                                             |             
      Endometrium, Hyperplasia, Cystic     | 2              2     1  1     4                 2           3     4      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3     4  3  3  3  3  3  3  4     3  2  3  3  3  2  2  3  2  2  2  3  2   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                                      +                    +  +  +     +|             
      Angiectasis                          |                                                                          |             
      Mediastinal, Ectasia                 |                                                             2           2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4|             
                             DAY ON TEST   | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7|             
                                           | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5|             
    1000 UG                                | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                         2|             
      Mediastinal, Hyperplasia, Histiocytic|                                                             2            |             
      Mediastinal, Hyperplasia, Plasma Cell| 2                                      2                                 |             
      Pancreatic, Hyperplasia, Histiocytic | 3                                                              3  2      |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                                   3      |             
      Pancreatic, Pigmentation             | 2                                                                        |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   2                 3              3              2      |             
      Hemorrhage                           |                                                                         2|             
      Hyperplasia, Lymphoid                |                   2              2                             2         |             
      Hyperplasia, Plasma Cell             | 2  2  2        3  2  3     3  3  3  3     3  2        2  3  3            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2     1  1  2  2  1  2  2  3  1  3  2     2  2  1  2  1     2  1  2  2  1|             
      Pigmentation                         | 2  2  2  1  2  2  2  1  1  1  2     1     1  2  1  2  2  2  2  1  2  2  3|             
      Lymphoid Follicle, Atrophy           |    3        2                                            3               |             
      Red Pulp, Atrophy                    |             2                                            3               |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  3  4  3  4  4  4  4  4  4  3     4  2  4  4  4  4  4  4  4  3  3|             
      Hemorrhage                           |                                        3                                 |             
      Inflammation                         |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |             1                                               1     1      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4|             
                             DAY ON TEST   | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7|             
                                           | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5|             
    1000 UG                                | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Inflammation                         |       3                                                                  |             
      Ulcer                                |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                             +            |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  2     2  2  1  1  1  2  2  2     2     1  2  1  1  2  1  2  1  1  1  1|             
      Inflammation                         |       3                                                                  |             
      Metaplasia, Squamous                 | 2                          2  3              2        2  2  2           3|             
      Alveolar Epithelium, Hyperplasia     |                      1              2                       2            |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 3        2  2  1  1     1  2  2              3  2  1           2  2     1|             
      Bronchiole, Hyperplasia              |                                                                          |             
      Mediastinum, Hemorrhage              |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                             |             
      Inflammation                         | 2  1        1  1  1  1  1  3  2     1              2  2  1        1     1|             
      Glands, Hyperplasia                  |             2  2           2                       2  2                  |             
      Olfactory Epithelium, Degeneration   |    2                                                                     |             
      Olfactory Epithelium, Metaplasia     | 2           2  2           3  2     2              2  2                  |             
      Respiratory Epithelium, Hyperplasia  | 3           3  2  3     2     3     2              3  3                 2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 6| 7| 5| 7| 5| 7| 7| 1| 7| 0| 5| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4|             
                             DAY ON TEST   | 2| 7| 1| 1| 0| 2| 6| 3| 8| 2| 2| 6| 3| 7| 4| 3| 2| 3| 4| 1| 5| 3| 3| 9| 7|             
                                           | 9| 4| 4| 4| 6| 9| 3| 0| 1| 9| 9| 9| 1| 6| 0| 0| 9| 0| 7| 9| 4| 0| 1| 9| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5|             
    1000 UG                                | 1| 2| 3| 4| 7| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 3| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Hemorrhage      |                                                                          |             
      Peritracheal Tissue, Inflammation    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Ciliary Body,      |                                                                          |             
          Cornea, Inflammation             |       3           3                                   3                  |             
      Retina, Atrophy                      | 2              2                    2                             3      |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       3     1                 1     1        1     1  3           1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                      3   |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1  1  1  1     1  1  1  1  1  1           1  1  1        1     1  1     1|             
      Nephropathy                          | 2  1  2  1  4  3  2  2     3  3     2     2  3  2  2  2     2  3  3     2|             
      Pigmentation                         | 3     2  3     3  2  4  2  2  2     2        3  3  1  2  1  2  2  1      |             
      Pelvis, Dilatation                   |                                                                      3   |             
      Pelvis, Inflammation                 |                                                       2        1     2   |             
      Renal Tubule, Degeneration           |                      3                                                   |             
      Transitional Epithelium, Hyperplasia |                                                       2              3   |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                      +   |             
      Mineralization                       |                                                                      3   |             
      Transitional Epithelium, Hyperplasia |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6|             
                                           | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    1000 UG                                | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Perforation                          |                                                    X                     |             
      Muscularis, Inflammation             |                                                                          |             
      Periesophageal Tissue, Hemorrhage    |                                                    3                     |             
      Periesophageal Tissue, Inflammation  |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             
      Parasite Metazoan                    |                   X                                                      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2        2                                 |             
      Basophilic Focus                     |                                        X                       X         |             
      Basophilic Focus, Multiple           |                            X  X     X                                    |             
      Cholangiofibrosis                    | 3     2  3  4  3  3     2  4  3        3  3  4              3  2     4  3|             
      Clear Cell Focus                     |                                                    X                     |             
      Eosinophilic Focus                   |                                                                          |             
      Eosinophilic Focus, Multiple         | X     X        X                 X  X     X           X     X     X     X|             
      Fatty Change, Diffuse                | 3     2        2  2  1  1  2  1  2  2     1        1     1  1     1  1   |             
      Fatty Change, Focal                  |          1  3                             3  2        1        1        2|             
      Hematopoietic Cell Proliferation     |    1                          1  1        1  1           1        1     1|             
      Hyperplasia, Nodular                 |       X  X  X  X  X     X  X  X  X     X  X  X        X     X  X     X  X|             
      Inflammation                         | 2  2  1  2  1  3  1  1  1  2  1  2  1  1  1  2        3  1     1     1  1|             
      Metaplasia                           |             1                                                            |             
      Mixed Cell Focus                     |                               X                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6|             
                                           | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    1000 UG                                | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Mixed Cell Focus, Multiple           |                                              X                           |             
      Necrosis                             |    2  2        3        2        3           3     2           1  2      |             
      Pigmentation                         | 2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2        2  1  2  2  2  2  2|             
      Toxic Hepatopathy                    | 3  1  3  4  4  3  4  2  4  4  4  3  2  4  4  4        3     4  4  3  4  3|             
      Bile Duct, Cyst                      |          3  3     2        2           2  2  2              3  2     2   |             
      Bile Duct, Hyperplasia               | 1     1  2  2  2  2  2  3  2  2  1  1  2  2  2        3     2  2  1  2  2|             
      Centrilobular, Degeneration          |    2                 2                                                   |             
      Centrilobular, Fibrosis              |                      2                                                   |             
      Hepatocyte, Hypertrophy              | 3  2  4  3  4  3  4  3  4  4  3  3  3  3  4  4        2  1  4  3  3  3  4|             
      Hepatocyte, Multinucleated           | 2  2  3  2     2  1  2  2  2  2  2  3  1  1  1        3  1  2  1  2  2  2|             
      Oval Cell, Hyperplasia               | 2     2  3  4  2  3  2  4  4  3  1  1  3  4  3        4     3  3  1  3  2|             
      Portal, Fibrosis                     |       2  2  3  3  2     2  3  2        2  3  3              2  2     2  2|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  M|             
      Artery, Inflammation, Chronic Active |       3                                   3           3                  |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +     +  +  +  +  +     +  +     +  +     +                 +  +  +  +  +|             
      Gingival, Hyperplasia, Squamous      |          2     2  1        4     2  1     2                    2  3  2  2|             
      Pharyngeal, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       2  1                                            3                  |             
      Acinus, Atrophy                      |          1                          2                 3                  |             
      Acinus, Vacuolization Cytoplasmic    | 2     2  2  2     2  1  2  2  2  2     1  2  3              2  1  1  2  3|             
      Artery, Inflammation, Chronic Active |                                                       3                  |             
      Duct, Dilatation                     |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                   3  1                    2                    2         |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Erosion                              |                                  2                 2                     |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +  +  +     +        +  +  +  +     +                 +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6|             
                                           | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    1000 UG                                | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Peridontal Tissue, Inflammation      | 1     2  1  1     1        1  1  2  1     2                 3  1  2  1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             1     1  1     1  1  1                                      1|             
      Fibrosis                             |                      2                                                   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Thrombosis                           |                      3                                                   |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |          1  1     1        1                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1     2           2                                   2         |             
      Atrophy                              | 2     2  2  3     2     3  3  3  2     2  3  3        4     3  2     2   |             
      Degeneration, Cystic                 | 3           2           2        3     2  1  3                 2         |             
      Hyperplasia                          | 3     2  1        2     2  2              3  3              4  4  3      |             
      Hypertrophy                          |          3     3  2     3  2  2  4  1  2     4        1     4        1  1|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |       2  1  3                 1                             1            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      3                                      2            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2                                                            |             
      Pars Distalis, Hyperplasia           |          2                 2              1                              |             
      Pars Intermedia, Hyperplasia         |                      3  2                                                |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6|             
                                           | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    1000 UG                                | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             2     1     2              2  2                 2     2      |             
      Follicular Cell, Hypertrophy         | 2  2  1  3  2     1     1  2  2        2  1  2     3  2  2  2  2  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1        1        1     1     1        1              1           2  1  1|             
      Duct, Cyst                           | 3     2     2     2  2  3     3  2  3  2  2  3        2  3  3  2  2  2  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4     4                    4           4        4     4            |             
      Cyst                                 |       3                                2  2                 2     2  3  2|             
      Inflammation, Chronic Active         |                                  4                                       |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                  +  +     +                              |             
      Inflammation, Chronic Active         |                                  3  3     3                              |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Hemorrhage                           |                                  3                                       |             
      Inflammation, Chronic Active         |                                     4     3                              |             
      Inflammation, Suppurative            |             2                                                            |             
      Metaplasia, Squamous                 |       2     3                    2  2                       3  1         |             
      Ulcer                                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |          4                                3                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  4  3  2  2  3  2     2  3  2  2  2  2  3  3  2  3  3  3  3  3  4  3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +     +  +  +     +           +  +                    +         |             
      Angiectasis                          |          2                                                               |             
      Mediastinal, Ectasia                 |                      2                                                   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6|             
                                           | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    1000 UG                                | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Mediastinal, Hemorrhage              |                3                                                         |             
      Mediastinal, Hyperplasia, Histiocytic|                2  3                                                      |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Ectasia                       |                                                                2         |             
      Renal, Hyperplasia, Histiocytic      |                            2                                   3         |             
      Renal, Hyperplasia, Lymphoid         |                                           3                              |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2                                               2   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |          4        2                                                      |             
      Hyperplasia, Plasma Cell             |       2  2  2     2  2  2  2  3        3     2        3        3     2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                   3                                                      |             
      Hyperplasia, Lymphoid                |                         3                                                |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4  1  2  2     2     1  2  1  2     1  2  1        1  3  1  2  3  2  2|             
      Pigmentation                         | 3     3  1  1     1  1  2  2  2  2  2  2  1        2  1  1     1  1  2  2|             
      Lymphoid Follicle, Atrophy           | 2     2                                                                  |             
      Red Pulp, Atrophy                    | 2     2                             2                                    |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  2  4  4  4  4  4  4     3  3  4  4  2  2  3     2  4     4  4  4  3  2|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3                                                                  |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6|             
                                           | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    1000 UG                                | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
      Hemorrhage                           |                                                    3                     |             
      Inflammation                         |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |       1  2  2  2  1  2  1  1  2  2  1  2  1  2        1     1  2  1  2  2|             
      Inflammation                         |                                                                          |             
      Metaplasia, Squamous                 |       2                             1                                    |             
      Alveolar Epithelium, Hyperplasia     |          1                                                               |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |       2  3  2     2     2  1  2  2  1  2  2  2              2  2     2  3|             
      Bronchiole, Hyperplasia              |             3                                                            |             
      Mediastinum, Hemorrhage              |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         | 1     1  1  1     2        2     1  1  1           1           1  1  2  1|             
      Glands, Hyperplasia                  | 2                          2                                   2         |             
      Olfactory Epithelium, Degeneration   |                                                    2                     |             
      Olfactory Epithelium, Metaplasia     | 3     2           2        2           2                       2         |             
      Respiratory Epithelium, Hyperplasia  | 3     3           3        3     2  2  2                       3     2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 _____________________________________________________________________________________________________________________              
                                           | 5| 1| 6| 7| 7| 5| 7| 3| 5| 7| 7| 4| 4| 7| 7| 7| 4| 0| 5| 2| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 9| 8| 4| 3| 3| 5| 2| 1| 8| 3| 3| 8| 9| 3| 2| 3| 2| 7| 6| 0| 0| 2| 7| 3| 6|             
                                           | 5| 1| 0| 1| 1| 8| 9| 4| 0| 1| 1| 5| 1| 0| 9| 1| 6| 1| 3| 6| 6| 9| 9| 1| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 NG/                               | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
    1000 UG                                | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Hemorrhage      |                                                    3                     |             
      Peritracheal Tissue, Inflammation    |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |             +                                                            |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Ciliary Body,      |                                                                          |             
          Cornea, Inflammation             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   1  1  3  1                                   1  1     1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Accumulation, Hyaline Droplet        |                                                          1               |             
      Calculus Micro Observation Only      |                                        X                                 |             
      Infarct                              |                                     2                                    |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1     1  1  1  1        1     1  1        1  1     1     1  1  1  1  1  1|             
      Nephropathy                          | 2     3  2  3     1  2  2  2  3  1  1  2  3  2        2     4  2  1  2  1|             
      Pigmentation                         | 2     1  2  2           2  1  1        2  2  2        2     2  2     1   |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation                 |                                  2                                       |             
      Renal Tubule, Degeneration           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                  3  1        2                           |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 3|                                                                 |            |
                                           | 9| 9| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    1000 NG/                               | 9| 9| 9|                                                                 |      L     |
    1000 UG                                | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  52        |
      Cyst                                 |                                                                          |      1  3.0|
      Perforation                          |                                                                          |      2     |
      Muscularis, Inflammation             |                                                                          |      3  2.0|
      Periesophageal Tissue, Hemorrhage    |                                                                          |      1  3.0|
      Periesophageal Tissue, Inflammation  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  50        |
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
      Parasite Metazoan                    | X                                                                        |      3     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  49        |
      Hyperplasia, Lymphoid                |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  49        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  51        |
      Angiectasis                          | 2                                                                        |      5  2.2|
      Basophilic Focus                     |    X                                                                     |      3     |
      Basophilic Focus, Multiple           |                                                                          |      3     |
      Cholangiofibrosis                    | 3  2  2                                                                  |     39  3.2|
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Eosinophilic Focus, Multiple         |    X  X                                                                  |     17     |
      Fatty Change, Diffuse                | 2  2  1                                                                  |     38  1.6|
      Fatty Change, Focal                  |    2                                                                     |     12  1.9|
      Hematopoietic Cell Proliferation     |                                                                          |     11  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 3|                                                                 |            |
                                           | 9| 9| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    1000 NG/                               | 9| 9| 9|                                                                 |      L     |
    1000 UG                                | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hyperplasia, Nodular                 | X  X  X                                                                  |     42     |
      Inflammation                         | 1  1  1                                                                  |     46  1.5|
      Metaplasia                           |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Mixed Cell Focus, Multiple           |                                                                          |      2     |
      Necrosis                             | 2                                                                        |     20  2.3|
      Pigmentation                         | 2  2  2                                                                  |     50  2.0|
      Toxic Hepatopathy                    | 4  3  4                                                                  |     49  3.5|
      Bile Duct, Cyst                      | 2     2                                                                  |     23  2.4|
      Bile Duct, Hyperplasia               | 2  1  2                                                                  |     46  2.0|
      Centrilobular, Degeneration          |                                                                          |      3  2.3|
      Centrilobular, Fibrosis              |                                                                          |      1  2.0|
      Hepatocyte, Hypertrophy              | 4  3  3                                                                  |     50  3.3|
      Hepatocyte, Multinucleated           | 1  1  1                                                                  |     48  1.9|
      Oval Cell, Hyperplasia               | 3  2  3                                                                  |     46  2.9|
      Portal, Fibrosis                     | 2  2                                                                     |     34  2.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +                                                                  |  42        |
      Artery, Inflammation, Chronic Active |                                                                          |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |    +  +                                                                  |  36        |
      Gingival, Hyperplasia, Squamous      |    1                                                                     |     24  1.8|
      Pharyngeal, Inflammation             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  50        |
      Inflammation, Chronic Active         |       1                                                                  |      4  1.8|
      Acinus, Atrophy                      |       1                                                                  |      8  1.6|
      Acinus, Vacuolization Cytoplasmic    | 1  2  1                                                                  |     40  1.9|
      Artery, Inflammation, Chronic Active | 3                                                                        |      2  3.0|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  51        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 3|                                                                 |            |
                                           | 9| 9| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    1000 NG/                               | 9| 9| 9|                                                                 |      L     |
    1000 UG                                | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hyperplasia, Squamous                |    1                                                                     |      8  1.8|
      Ulcer                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  51        |
      Cyst                                 |                                                                          |      1  1.0|
      Erosion                              |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +  +                                                                  |  31        |
      Peridontal Tissue, Inflammation      |    2  2                                                                  |     31  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Cardiomyopathy                       | 1     1                                                                  |     15  1.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  51        |
      Angiectasis                          |                                                                          |      5  1.8|
      Atrophy                              | 2  2  3                                                                  |     35  2.6|
      Degeneration, Cystic                 |                                                                          |     16  1.9|
      Hyperplasia                          | 2                                                                        |     19  2.6|
      Hypertrophy                          |    2                                                                     |     32  2.2|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 1  1                                                                     |     13  1.6|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 3|                                                                 |            |
                                           | 9| 9| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    1000 NG/                               | 9| 9| 9|                                                                 |      L     |
    1000 UG                                | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +                                                                  |  51        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  46        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |    2                                                                     |     13  2.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      C-Cell, Hyperplasia                  |                                                                          |     15  1.7|
      Follicular Cell, Hypertrophy         | 1  2  2                                                                  |     42  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  50        |
      Inflammation                         | 2  1  1                                                                  |     23  1.1|
      Duct, Cyst                           | 2  3  3                                                                  |     43  2.4|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  49        |
      Atrophy                              |    4  3                                                                  |     16  3.8|
      Cyst                                 |    3                                                                     |     13  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   3        |
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 3|                                                                 |            |
                                           | 9| 9| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    1000 NG/                               | 9| 9| 9|                                                                 |      L     |
    1000 UG                                | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Adenomyosis                          |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
      Inflammation, Suppurative            |    2                                                                     |      5  2.0|
      Metaplasia, Squamous                 |                                                                          |     14  2.4|
      Ulcer                                |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |    3  2                                                                  |     12  2.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 2  3  3                                                                  |     49  2.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  14        |
      Angiectasis                          |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |                                                                          |      3  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      2  2.5|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      3  2.3|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      2  2.0|
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |      3  2.7|
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |      1  3.0|
      Pancreatic, Pigmentation             |                                                                          |      1  2.0|
      Renal, Ectasia                       |                                                                          |      1  2.0|
      Renal, Hyperplasia, Histiocytic      |                                                                          |      2  2.5|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Ectasia                              |                                                                          |      6  2.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.4|
      Hyperplasia, Plasma Cell             | 3     3                                                                  |     31  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  49        |
      Hyperplasia, Histiocytic             | 2                                                                        |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 3|                                                                 |            |
                                           | 9| 9| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    1000 NG/                               | 9| 9| 9|                                                                 |      L     |
    1000 UG                                | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  50        |
      Hematopoietic Cell Proliferation     | 2  2  2                                                                  |     44  1.8|
      Pigmentation                         | 1  2  1                                                                  |     46  1.7|
      Lymphoid Follicle, Atrophy           |                                                                          |      5  2.4|
      Red Pulp, Atrophy                    |                                                                          |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  51        |
      Atrophy                              | 4  4  4                                                                  |     49  3.6|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  52        |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 3|                                                                 |            |
                                           | 9| 9| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    1000 NG/                               | 9| 9| 9|                                                                 |      L     |
    1000 UG                                | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  52        |
      Infiltration Cellular, Histiocyte    | 2  2  1                                                                  |     45  1.5|
      Inflammation                         |                                                                          |      1  3.0|
      Metaplasia, Squamous                 |    2                                                                     |     11  2.1|
      Alveolar Epithelium, Hyperplasia     |       1                                                                  |      5  1.4|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 2  2                                                                     |     32  1.9|
      Bronchiole, Hyperplasia              |                                                                          |      1  3.0|
      Mediastinum, Hemorrhage              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation                         | 2  1                                                                     |     31  1.3|
      Glands, Hyperplasia                  |                                                                          |      8  2.0|
      Olfactory Epithelium, Degeneration   |                                                                          |      2  2.0|
      Olfactory Epithelium, Metaplasia     | 3                                                                        |     15  2.2|
      Respiratory Epithelium, Hyperplasia  | 3                                                                        |     20  2.6|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  52        |
      Peritracheal Tissue, Hemorrhage      |                                                                          |      1  3.0|
      Peritracheal Tissue, Inflammation    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 10:01:01    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 2| 2| 3|                                                                 |            |
                                           | 9| 9| 0|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    1000 NG/                               | 9| 9| 9|                                                                 |      L     |
    1000 UG                                | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Anterior Chamber, Ciliary Body,      |                                                                          |            |
          Cornea, Inflammation             |                                                                          |      3  3.0|
      Retina, Atrophy                      |       2                                                                  |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  52        |
      Inflammation                         | 1                                                                        |     16  1.4|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  51        |
      Accumulation, Hyaline Droplet        |                                                                          |      1  1.0|
      Calculus Micro Observation Only      |                                                                          |      1     |
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |       2                                                                  |      1  2.0|
      Mineralization                       |    1                                                                     |     35  1.0|
      Nephropathy                          | 2  2  3                                                                  |     43  2.2|
      Pigmentation                         | 2  1  2                                                                  |     35  2.0|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Pelvis, Inflammation                 |       2                                                                  |      5  1.8|
      Renal Tubule, Degeneration           |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |       2                                                                  |      6  2.2|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Mineralization                       |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
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